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Conserved domains on  [gi|1622929125|ref|XP_028702668|]
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natural cytotoxicity triggering receptor 3 isoform X1 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 40-151 7.28e-83

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


:

Pssm-ID: 409520  Cd Length: 112  Bit Score: 242.96  E-value: 7.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  40 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLSSSRFLRDHQAELHIWD 119
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622929125 120 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 151
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 40-151 7.28e-83

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 242.96  E-value: 7.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  40 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLSSSRFLRDHQAELHIWD 119
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622929125 120 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 151
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-149 3.67e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 3.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  45 QPPEIRTLEGSSAFLPCSFNASQGrLAIGSVTWFRDEVAPGKEV-----RNGTPEFRGRlAPLSSSRFLRDHQAELHIWD 119
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFliayySNGSEEGVKK-GRFSGRGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622929125 120 VRGHDAGIYVCRVeVLGLGVGTGNGTRLVV 149
Cdd:pfam07686  80 LTLSDSGTYTCAV-IPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 46-149 1.17e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.57  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125   46 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVAPgkevrngtpefrgrlaPLSSSRFLRDH---QAELHIWDVRG 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKL----------------LAESGRFSVSRsgsTSTLTISNVTP 60

                           90       100
                   ....*....|....*....|....*..
gi 1622929125  123 HDAGIYVCRVEVlGLGVGTGnGTRLVV 149
Cdd:smart00410  61 EDSGTYTCAATN-SSGSASS-GTTLTV 85
 
Name Accession Description Interval E-value
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 40-151 7.28e-83

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 242.96  E-value: 7.28e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  40 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLSSSRFLRDHQAELHIWD 119
Cdd:cd20926     1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLASSRFLRDHQAELHIWD 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622929125 120 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 151
Cdd:cd20926    81 VRGHDAGIYVCRVEVLGLGVGTGNGTRLVVEK 112
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 45-149 3.67e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 3.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  45 QPPEIRTLEGSSAFLPCSFNASQGrLAIGSVTWFRDEVAPGKEV-----RNGTPEFRGRlAPLSSSRFLRDHQAELHIWD 119
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTYSSSMS-EASTSVYWYRQPPGKGPTFliayySNGSEEGVKK-GRFSGRGDPSNGDGSLTIQN 79

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622929125 120 VRGHDAGIYVCRVeVLGLGVGTGNGTRLVV 149
Cdd:pfam07686  80 LTLSDSGTYTCAV-IPSGEGVFGKGTRLTV 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 46-149 1.17e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 45.57  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125   46 PPEIRTLEGSSAFLPCSFNASqgrlAIGSVTWFRDEVAPgkevrngtpefrgrlaPLSSSRFLRDH---QAELHIWDVRG 122
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGGKL----------------LAESGRFSVSRsgsTSTLTISNVTP 60

                           90       100
                   ....*....|....*....|....*..
gi 1622929125  123 HDAGIYVCRVEVlGLGVGTGnGTRLVV 149
Cdd:smart00410  61 EDSGTYTCAATN-SSGSASS-GTTLTV 85
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 46-132 5.58e-06

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 43.72  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  46 PPEIRTLEGSSAFLPCSfnASQGRLAIgSVTWFRDevapGKEVRNGTPEFRGRLaplsssrflRDHQAELHIWDVRGHDA 125
Cdd:pfam00047   3 PPTVTVLEGDSATLTCS--ASTGSPGP-DVTWSKE----GGTLIESLKVKHDNG---------RTTQSSLLISNVTKEDA 66


                  ....*..
gi 1622929125 126 GIYVCRV 132
Cdd:pfam00047  67 GTYTCVV 73
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 43-133 7.81e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 42.94  E-value: 7.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  43 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDevapGKEVRNGTpefrgrlaplSSSRFLRDHQAELHIW 118
Cdd:pfam13927   5 TVSPSSVTVREGETVTLTCE--------ATGspppTITWYKN----GEPISSGS----------TRSRSLSGSNSTLTIS 62

                          90
                  ....*....|....*
gi 1622929125 119 DVRGHDAGIYVCRVE 133
Cdd:pfam13927  63 NVTRSDAGTYTCVAS 77
IGv smart00406
Immunoglobulin V-Type;
56-130 1.19e-05

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 42.37  E-value: 1.19e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125   56 SAFLPCSFnaSQGRLAIGSVTWFRdeVAPGKEV-----------RNGTPEFRGRLaplSSSRFLRDHQAELHIWDVRGHD 124
Cdd:smart00406   1 SVTLSCKF--SGSTFSSYYVSWVR--QPPGKGLewlgyigsngsSYYQESYKGRF---TISKDTSKNDVSLTISNLRVED 73


                   ....*.
gi 1622929125  125 AGIYVC 130
Cdd:smart00406  74 TGTYYC 79
I-set pfam07679
Immunoglobulin I-set domain;
43-133 1.55e-05

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 42.24  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  43 VSQPPEIRTLEGSSAFLPCSfnasqgrlAIG----SVTWFRDevapGKEVRngtpefrgrlaplSSSRFL---RDHQAEL 115
Cdd:pfam07679   4 TQKPKDVEVQEGESARFTCT--------VTGtpdpEVSWFKD----GQPLR-------------SSDRFKvtyEGGTYTL 58

                          90
                  ....*....|....*...
gi 1622929125 116 HIWDVRGHDAGIYVCRVE 133
Cdd:pfam07679  59 TISNVQPDDSGKYTCVAT 76
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 57-133 1.69e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 41.93  E-value: 1.69e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622929125  57 AFLPCSFNASQGrlaiGSVTWFRDevapGKEVRNGTpefrgrlaplSSSRFLRDHQAELHIWDVRGHDAGIYVCRVE 133
Cdd:cd00096     1 VTLTCSASGNPP----PTITWYKN----GKPLPPSS----------RDSRRSELGNGTLTISNVTLEDSGTYTCVAS 59
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 43-132 4.90e-05

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 41.66  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  43 VSQPPEIRTLEGSSAFLPCSFnASQGRLAIGSVTWFRDEVAPGKEVRNGTPEF--------RGRLAPLSSSRFLRDhqAE 114
Cdd:cd05718     3 VQVPTEVTGFLGGSVTLPCSL-TSPGTTKITQVTWMKIGAGSSQNVAVFHPQYgpsvpnpyAERVEFLAARLGLRN--AT 79

                          90
                  ....*....|....*...
gi 1622929125 115 LHIWDVRGHDAGIYVCRV 132
Cdd:cd05718    80 LRIRNLRVEDEGNYICEF 97
IgV_P0-like cd05715
Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here ...
 43-132 6.36e-05

Immunoglobulin (Ig)-like domain of protein zero (P0) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of protein zero (P0), a myelin membrane adhesion molecule. P0 accounts for over 50% of the total protein in peripheral nervous system (PNS) myelin. P0 is a single-pass transmembrane glycoprotein with a highly basic intracellular domain and an extracellular Ig domain. The extracellular domain of P0 (P0-ED) is similar to the Ig variable domain, carrying one acceptor sequence for N-linked glycosylation. P0 plays a role in membrane adhesion in the spiral wraps of the myelin sheath. The intracellular domain is thought to mediate membrane apposition of the cytoplasmic faces and may, through electrostatic interactions, interact directly with lipid headgroups. It is thought that homophilic interactions of the P0 extracellular domain mediate membrane juxtaposition in the extracellular space of PNS myelin. This group also contains the Ig domain of sodium channel subunit beta-2 (SCN2B), and of epithelial V-like antigen 1 (EVA). EVA, also known as myelin protein zero-like 2, is an adhesion molecule, which may play a role in structural organization of the thymus and early lymphocyte development. SCN2B subunits play a role in determining sodium channel density and function in neurons,and in control of electrical excitability in the brain.


Pssm-ID: 409380  Cd Length: 117  Bit Score: 41.26  E-value: 6.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  43 VSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTW-FRDEvapgkevrNGTPE------FRGRLAPLSSSRF-------- 107
Cdd:cd05715     3 VYTPRELNVLNGSDVRLTCTFTSCYTVGDAFSVTWtYQPE--------GGNTTesmfhySKGKPYILKVGRFkdrvswag 74

                          90       100
                  ....*....|....*....|....*.
gi 1622929125 108 -LRDHQAELHIWDVRGHDAGIYVCRV 132
Cdd:cd05715    75 nPSKKDASIVISNLQFSDNGTYTCDV 100
IgV_MOG_like cd05713
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here ...
 49-133 9.52e-05

Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG); The members here are composed of the immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).


Pssm-ID: 409378  Cd Length: 114  Bit Score: 40.64  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  49 IRTLEGSSAFLPCSFNASQGrLAIGSVTWFRDEVAPGKEV-RNGT-------PEFRGRlaplssSRFLRDHQAE----LH 116
Cdd:cd05713    10 ILALVGEDAELPCHLSPKMS-AEHMEVRWFRSQFSPVVHLyRDGQdqeeeqmPEYRGR------TELLKDAIAEgsvaLR 82

                          90
                  ....*....|....*..
gi 1622929125 117 IWDVRGHDAGIYVCRVE 133
Cdd:cd05713    83 IHNVRPSDEGQYTCFFR 99
IgV_CTLA-4 cd05721
Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); ...
 43-149 6.90e-04

Immunoglobulin Variable (IgV) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4); The members here are composed of the variable(v)-type immunoglobulin (Ig) domain found in cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). CTLA-4 is involved in the regulation of T cell response, acting as an inhibitor of intracellular signaling. CTLA-4 is similar to CD28, a T cell co-receptor protein that recognizes the B7 proteins (CD80 and CD86). CD28 binding of the B7 proteins occurs after the presentation of antigen to the T cell receptor (TCR) via the peptide-MHC complex on the surface of an antigen presenting cell (APC). CTLA-4 also binds the B7 molecules with a higher affinity than does CD28. The B7/CTLA-4 interaction generates inhibitory signals down-regulating the response, and may prevent T cell activation by weak TCR signals. CD28 and CTLA-4 then elicit opposing signals in the regulation of T cell responsiveness and homeostasis. T cell activation leads to increased CTLA-4 gene expression and trafficking of CTLA-4 protein to the cell surface. CTLA-4 is not detected on the T-cell surface until 24 hours after activation. Covalent dimerization of CTLA-4 has been shown to be required for its high binding avidity, although each CTLA-4 monomer contains a binding site for CD80 and CD86.


Pssm-ID: 409386  Cd Length: 115  Bit Score: 38.44  E-value: 6.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  43 VSQPPEIRTLEGSSAFLPCSFnASQGRLAIGSVTWFRDEVAPGKEVRNGTPEFRGRLAPLSSSR---FLRDHQAELHIWD 119
Cdd:cd05721     2 VAQPAVVLASSRGVASFVCEY-ASSGNATEVRVTVLRQADSQMTEVCAATYTMGNELTFLDDSIctgTSSGNQVNLTIQG 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622929125 120 VRGHDAGIYVCRVEVL---GLGVGTGNGTRLVV 149
Cdd:cd05721    81 LRAMDTGLYICKVELMyppPYYVGMGNGTQIYV 113
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 43-149 1.39e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 37.31  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622929125  43 VSQPPEIRTL-EGSSAFLPCSFNasqGRLAIGSVTWFRdevapgkEVRNGTPEF-------RGRLAPLSSSRFL----RD 110
Cdd:cd00099     1 VTQSPRSLSVqEGESVTLSCEVS---SSFSSTYIYWYR-------QKPGQGPEFliylsssKGKTKGGVPGRFSgsrdGT 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1622929125 111 HQAELHIWDVRGHDAGIYVC-RVEVLGLGVGT-GNGTRLVV 149
Cdd:cd00099    71 SSFSLTISNLQPEDSGTYYCaVSESGGTDKLTfGSGTRLTV 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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