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Conserved domains on  [gi|1622928912|ref|XP_028702607|]
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kelch-like protein 32 isoform X6 [Macaca mulatta]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 20871882)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-372 3.98e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 3.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 101 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 179
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 180 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 256
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 257 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 335
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1622928912 336 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 372
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
Kelch smart00612
Kelch domain;
68-123 1.94e-05

Kelch domain;


:

Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928912   68 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 123
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-372 3.98e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 3.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 101 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 179
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 180 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 256
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 257 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 335
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1622928912 336 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 372
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
PHA03098 PHA03098
kelch-like protein; Provisional
 66-304 4.83e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 103.69  E-value: 4.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912  66 DTLYIIGGKKREVCKVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTA 145
Cdd:PHA03098  295 NVIYFIGGMNKNNLSVNSVVSYDTKTKS---------WNKVPELIYPRKNPGVTVFNNRIYVIGGI-----YNSISLNTV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 146 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLL 225
Cdd:PHA03098  361 ESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 226 WISGGVTNTAQYQ--NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQW 303
Cdd:PHA03098  441 YVIGGISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTW 515


                  .
gi 1622928912 304 T 304
Cdd:PHA03098  516 T 516
Kelch_6 pfam13964
Kelch motif;
113-165 1.12e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622928912 113 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 165
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch smart00612
Kelch domain;
68-123 1.94e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928912   68 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 123
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch smart00612
Kelch domain;
177-208 3.10e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 3.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622928912  177 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 208
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
101-372 3.98e-40

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 143.76  E-value: 3.98e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 101 ANWSELAPMPVGRSHHCVAVMGDFLFVAGGeveHASGRtcAVRTACRYDPRSNSWAEIAPMKNC-REHFVLGAMEEYLYA 179
Cdd:COG3055     1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGG---LSGGS--ASNSFEVYDPATNTWSELAPLPGPpRHHAAAVAQDGKLYV 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 180 VGGRNEL---RQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAqYQNRLMVYEPNQNKWISRSP 256
Cdd:COG3055    76 FGGFTGAnpsSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG-NVAWVEVYDPATGTWTQLAP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 257 MLQRRVYHSMAAV-ERKLYVLGGndldynndrilvrhiDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSIW 335
Cdd:COG3055   155 LPTPRDHLAAAVLpDGKILVIGG---------------RNGSGFSNTWTTLA-PLPTARAGHAAAVLGGKILVFGGESGF 218

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1622928912 336 TNEplacIQVLDVSREGKEEVfygPTLPFASNGIAAC 372
Cdd:COG3055   219 SDE----VEAYDPATNTWTAL---GELPTPRHGHAAV 248
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
66-278 6.06e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.32  E-value: 6.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912  66 DTLYIIGGkkrevckvkeLRYFNPVDQENALIAAIANWSELAPMP-VGRSHHCVAVMGDFLFVAGGEVEHASGRTcAVRT 144
Cdd:COG3055    23 GKVYVAGG----------LSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFGGFTGANPSST-PLND 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 145 ACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVlPTVERYCPKKNKWTFVQSFDRSLSCHAGYVA-DG 223
Cdd:COG3055    92 VYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNV-AWVEVYDPATGTWTQLAPLPTPRDHLAAAVLpDG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 224 LLWISGGVTNTAQYQ---------------------NRLMV-------------YEPNQNKWISRSPMLQRRVYHSMAAV 269
Cdd:COG3055   171 KILVIGGRNGSGFSNtwttlaplptaraghaaavlgGKILVfggesgfsdeveaYDPATNTWTALGELPTPRHGHAAVLT 250


                  ....*....
gi 1622928912 270 ERKLYVLGG 278
Cdd:COG3055   251 DGKVYVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 66-304 4.83e-24

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 103.69  E-value: 4.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912  66 DTLYIIGGKKREVCKVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTA 145
Cdd:PHA03098  295 NVIYFIGGMNKNNLSVNSVVSYDTKTKS---------WNKVPELIYPRKNPGVTVFNNRIYVIGGI-----YNSISLNTV 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 146 CRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRNELRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLL 225
Cdd:PHA03098  361 ESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKI 440

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 226 WISGGVTNTAQYQ--NRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQW 303
Cdd:PHA03098  441 YVIGGISYIDNIKvyNIVESYNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTW 515


                  .
gi 1622928912 304 T 304
Cdd:PHA03098  516 T 516
PHA03098 PHA03098
kelch-like protein; Provisional
 117-367 2.71e-22

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 98.69  E-value: 2.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 117 CVAVMGDFLFVAGGEVEhasgRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRnELRQVLPTVERY 196
Cdd:PHA03098  289 GSVVLNNVIYFIGGMNK----NNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGI-YNSISLNTVESW 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 197 CPKKNKWTFVQS--FDRSLSCHAGYvaDGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLY 274
Cdd:PHA03098  364 KPGESKWREEPPliFPRYNPCVVNV--NNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIY 441

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 275 VLGGndLDYNNDRILVRHIDSYNIDTDQWTRCSFNLLTGQNESGVAVHNgRIYLVGGYSI--WTNEplacIQVLDVsrEG 352
Cdd:PHA03098  442 VIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFNN-KIYVVGGDKYeyYINE----IEVYDD--KT 512

                         250
                  ....*....|....*
gi 1622928912 353 KEEVFYGPTLPFASN 367
Cdd:PHA03098  513 NTWTLFCKFPKVIGS 527
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
64-245 1.26e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.43  E-value: 1.26e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912  64 QSDTLYIIGGKKREVCKVKELR---YFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGDFLFVAGGEVEHAsgrtc 140
Cdd:COG3055    69 QDGKLYVFGGFTGANPSSTPLNdvyVYDPATNT---------WTKLAPMPTPRGGATALLLDGKIYVVGGWDDGG----- 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 141 AVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEE-YLYAVGGRNE---------------------------------- 185
Cdd:COG3055   135 NVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLPDgKILVIGGRNGsgfsntwttlaplptaraghaaavlggkilvfgg 214

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 186 LRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYE 245
Cdd:COG3055   215 ESGFSDEVEAYDPATNTWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGVRTPLVTSAE 274
PLN02193 PLN02193
nitrile-specifier protein
 225-333 2.74e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 55.35  E-value: 2.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 225 LWISGGVTNTAQYqNRLMVYEPNQNKWISRSPMLQ---RRVYHSMAAVERKLYVLGGndldyNNDRILVRHIDSYNIDTD 301
Cdd:PLN02193  231 LYVFGGRDASRQY-NGFYSFDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGG-----VSATARLKTLDSYNIVDK 304

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622928912 302 QWTRCS--FNLLTGQNESGVAVHNGRIYLVGGYS 333
Cdd:PLN02193  305 KWFHCStpGDSFSIRGGAGLEVVQGKVWVVYGFN 338
Kelch_6 pfam13964
Kelch motif;
113-165 1.12e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.12e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622928912 113 RSHHCVAVMGDFLFVAGGevehASGRTCAVRTACRYDPRSNSWAEIAPMKNCR 165
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 110-333 1.31e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.31e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 110 PVGRSHHCVAVMGDFLFVAGGEV---EHASgrtcavRTACRYDPRSNSWAEIAPMKNCREHFVLG----AMEEYLYAVGG 182
Cdd:PLN02153   20 PGPRCSHGIAVVGDKLYSFGGELkpnEHID------KDLYVFDFNTHTWSIAPANGDVPRISCLGvrmvAVGTKLYIFGG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 183 RNELRQvLPTVERYCPKKNKWTFVQSFDrslschagyvadgllwISGGvtntaqyqnrlmvyepnqnkwisrsPmlQRRV 262
Cdd:PLN02153   94 RDEKRE-FSDFYSYDTVKNEWTFLTKLD----------------EEGG-------------------------P--EART 129

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622928912 263 YHSMAAVERKLYVLGG---NDLDYNNDRIlvRHIDSYNIDTDQWTRC-----SFNLLTGqneSGVAVHNGRIYLVGGYS 333
Cdd:PLN02153  130 FHSMASDENHVYVFGGvskGGLMKTPERF--RTIEAYNIADGKWVQLpdpgeNFEKRGG---AGFAVVQGKIWVVYGFA 203
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 260-307 5.96e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.98  E-value: 5.96e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622928912 260 RRVYHSMAAVERKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCS 307
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKLP 43
Kelch smart00612
Kelch domain;
68-123 1.94e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 41.39  E-value: 1.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928912   68 LYIIGGKKREVCkVKELRYFNPVDQEnaliaaianWSELAPMPVGRSHHCVAVMGD 123
Cdd:smart00612   2 IYVVGGFDGGQR-LKSVEVYDPETNK---------WTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 165-208 2.50e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.50e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622928912 165 REHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 208
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDG-NQSLNSVEVYDPETNTWSKLPS 44
PHA02713 PHA02713
hypothetical protein; Provisional
 157-300 3.25e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 45.77  E-value: 3.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 157 EIAPMKNCREHFVLGAMEEYLYAVGGRNElRQVLPTVERYCPKKNKWTFVQSFDRSLSCHAGYVADGLLWISGGVTNTAQ 236
Cdd:PHA02713  334 ELPPMIKNRCRFSLAVIDDTIYAIGGQNG-TNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRTEHID 412

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 237 Y-----------------QNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLggndLDYNNDRILVRHIDSYNID 299
Cdd:PHA02713  413 YtsvhhmnsidmeedthsSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVV----CDIKDEKNVKTCIFRYNTN 488


                  .
gi 1622928912 300 T 300
Cdd:PHA02713  489 T 489
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 113-162 5.02e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 40.29  E-value: 5.02e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622928912 113 RSHHCVAVMGDFLFVAGGevehaSGRTCAVRTACRYDPRSNSWAEIAPMK 162
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGG-----FDGNQSLNSVEVYDPETNTWSKLPSMP 46
PRK14131 PRK14131
N-acetylneuraminate epimerase;
266-333 1.03e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 1.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622928912 266 MAAVERKLYVLGGNDlDYNNDR--ILVRHIDSYNIDTDQW----TRCSFNLLTGqneSGVAVHNGRIYLVGGYS 333
Cdd:PRK14131   80 AAFIDGKLYVFGGIG-KTNSEGspQVFDDVYKYDPKTNSWqkldTRSPVGLAGH---VAVSLHNGKAYITGGVN 149
Kelch smart00612
Kelch domain;
177-208 3.10e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 38.31  E-value: 3.10e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622928912  177 LYAVGGRNElRQVLPTVERYCPKKNKWTFVQS 208
Cdd:smart00612   2 IYVVGGFDG-GQRLKSVEVYDPETNKWTPLPS 32
Kelch smart00612
Kelch domain;
272-324 3.70e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.92  E-value: 3.70e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1622928912  272 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCSfNLLTGQNESGVAVHNG 324
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
152-278 6.89e-04

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.54  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 152 SNSWAEIAPMKNC-REHFVLGAMEEYLYAVGG---RNE--LRQVLPTVERYCPKKNKWTFVQSFD-RSLSCHAGYVADG- 223
Cdd:PRK14131   61 SKGWTKIAAFPGGpREQAVAAFIDGKLYVFGGigkTNSegSPQVFDDVYKYDPKTNSWQKLDTRSpVGLAGHVAVSLHNg 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 224 LLWISGGV-----------TNTA----------------------QYQNRLMVYEPNQNKWIS--RSPMLQrRVYHSMAA 268
Cdd:PRK14131  141 KAYITGGVnknifdgyfedLAAAgkdktpkdkindayfdkkpedyFFNKEVLSYDPSTNQWKNagESPFLG-TAGSAVVI 219

                         170
                  ....*....|
gi 1622928912 269 VERKLYVLGG 278
Cdd:PRK14131  220 KGNKLWLING 229
PHA03098 PHA03098
kelch-like protein; Provisional
 199-334 8.18e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 41.29  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 199 KKNKWTFVQSfDRSLSCHAGYVADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVERKLYVLGG 278
Cdd:PHA03098  272 PLSEINTIID-IHYVYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG 350

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622928912 279 NDLDynndrILVRHIDSYNIDTDQWTRCSfNLLTGQNESGVAVHNGRIYLVGGYSI 334
Cdd:PHA03098  351 IYNS-----ISLNTVESWKPGESKWREEP-PLIFPRYNPCVVNVNNLIYVIGGISK 400
Kelch smart00612
Kelch domain;
224-270 1.79e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 36.00  E-value: 1.79e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1622928912  224 LLWISGGvTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAVE 270
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVIN 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
222-269 3.81e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.96  E-value: 3.81e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622928912 222 DGLLWISGG-VTNTAQYQNRLMVYEPNQNKWISRSPMLQRRVYHSMAAV 269
Cdd:pfam13415   1 GDKLYIFGGlGFDGQTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
260-307 3.94e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 3.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1622928912 260 RRVYHSMAAVER-KLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCS 307
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGG----EGEDGTLLSDLWVFDLSTNEWTRLG 45
Kelch smart00612
Kelch domain;
125-168 3.94e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.84  E-value: 3.94e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1622928912  125 LFVAGGeveHASGRTCavRTACRYDPRSNSWAEIAPMKNCREHF 168
Cdd:smart00612   2 IYVVGG---FDGGQRL--KSVEVYDPETNKWTPLPSMPTPRSGH 40
Kelch_6 pfam13964
Kelch motif;
261-307 6.89e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.62  E-value: 6.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1622928912 261 RVYHSMAAVERKLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCS 307
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEELP 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
112-161 8.59e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 8.59e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622928912 112 GRSHH-CVAVMGDFLFVAGGEVEhaSGRTCAvrTACRYDPRSNSWAEIAPM 161
Cdd:pfam13418   1 PRAYHtSTSIPDDTIYLFGGEGE--DGTLLS--DLWVFDLSTNEWTRLGSL 47
PHA02713 PHA02713
hypothetical protein; Provisional
 105-185 8.84e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 38.07  E-value: 8.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622928912 105 ELAPMPVGRSHHCVAVMGDFLFVAGGEvehasGRTCAVRTACRYDPRSNSWAEIAPMKNCREHFVLGAMEEYLYAVGGRN 184
Cdd:PHA02713  334 ELPPMIKNRCRFSLAVIDDTIYAIGGQ-----NGTNVERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQYIYIIGGRT 408


                  .
gi 1622928912 185 E 185
Cdd:PHA02713  409 E 409
Kelch_6 pfam13964
Kelch motif;
220-261 9.18e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 34.23  E-value: 9.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622928912 220 VADGLLWISGGVTNTAQYQNRLMVYEPNQNKWISRSPMLQRR 261
Cdd:pfam13964   9 SVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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