SUN domain-containing protein 1 isoform X28 [Macaca mulatta]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Sad1_UNC | pfam07738 | Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ... |
675-810 | 1.03e-58 | |||||
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm. : Pssm-ID: 400199 Cd Length: 130 Bit Score: 195.59 E-value: 1.03e-58
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| MRP | pfam09387 | Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ... |
62-319 | 6.76e-55 | |||||
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold. : Pssm-ID: 430576 Cd Length: 192 Bit Score: 187.85 E-value: 6.76e-55
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| SUN1_cc1 | cd21439 | coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ... |
444-497 | 6.65e-28 | |||||
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain. : Pssm-ID: 410605 [Multi-domain] Cd Length: 55 Bit Score: 106.60 E-value: 6.65e-28
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| HTH_SUN2 super family | cl39899 | SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ... |
574-632 | 1.60e-07 | |||||
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component. The actual alignment was detected with superfamily member pfam18580: Pssm-ID: 436594 [Multi-domain] Cd Length: 58 Bit Score: 48.48 E-value: 1.60e-07
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| CALCOCO1 super family | cl37761 | Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
393-566 | 9.69e-04 | |||||
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region. The actual alignment was detected with superfamily member pfam07888: Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 42.57 E-value: 9.69e-04
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| Name | Accession | Description | Interval | E-value | |||||
| Sad1_UNC | pfam07738 | Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ... |
675-810 | 1.03e-58 | |||||
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm. Pssm-ID: 400199 Cd Length: 130 Bit Score: 195.59 E-value: 1.03e-58
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| MRP | pfam09387 | Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ... |
62-319 | 6.76e-55 | |||||
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold. Pssm-ID: 430576 Cd Length: 192 Bit Score: 187.85 E-value: 6.76e-55
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| SUN1_cc1 | cd21439 | coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ... |
444-497 | 6.65e-28 | |||||
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain. Pssm-ID: 410605 [Multi-domain] Cd Length: 55 Bit Score: 106.60 E-value: 6.65e-28
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| HTH_SUN2 | pfam18580 | SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ... |
574-632 | 1.60e-07 | |||||
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component. Pssm-ID: 436594 [Multi-domain] Cd Length: 58 Bit Score: 48.48 E-value: 1.60e-07
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| CALCOCO1 | pfam07888 | Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
393-566 | 9.69e-04 | |||||
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region. Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 42.57 E-value: 9.69e-04
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| Name | Accession | Description | Interval | E-value | |||||
| Sad1_UNC | pfam07738 | Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ... |
675-810 | 1.03e-58 | |||||
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm. Pssm-ID: 400199 Cd Length: 130 Bit Score: 195.59 E-value: 1.03e-58
|
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| MRP | pfam09387 | Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins ... |
62-319 | 6.76e-55 | |||||
Mitochondrial RNA binding protein MRP; MRP1 and MRP2 are mitochondrial RNA binding proteins that form a heteromeric complex. The MRP1/MRP2 heterotetrameric complex binds to guide RNAs and stabilizes them in an unfolded conformation suitable for RNA-RNA hybridization. Each MRP subunit adopts a 'whirly' transcription factor fold. Pssm-ID: 430576 Cd Length: 192 Bit Score: 187.85 E-value: 6.76e-55
|
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| SUN1_cc1 | cd21439 | coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN ... |
444-497 | 6.65e-28 | |||||
coiled-coil domain 1 of SUN domain-containing protein 1 and similar proteins; SUN domain-containing protein 1 (SUN1), also called protein unc-84 homolog A, or Sad1/unc-84 protein-like 1, is a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN1 contains two coiled-coil domains (CC1 and CC2), which act as the intrinsic dynamic regulators for controlling the activity of the SUN domain. This model corresponds to CC1 that may function as an activation segment to release CC2-mediated inhibition of the SUN domain. Pssm-ID: 410605 [Multi-domain] Cd Length: 55 Bit Score: 106.60 E-value: 6.65e-28
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| SUN_cc1 | cd21435 | coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 ... |
444-498 | 2.40e-23 | |||||
coiled-coil domain 1 of SUN domain-containing proteins; SUN (Sad1 and UNC-84) proteins (SUN1 and SUN2) are components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex which is involved in the connection between the nuclear lamina and the cytoskeleton. Besides the core SUN domain, SUN proteins contain two coiled-coil domains (CC1 and CC2), which act as intrinsic dynamic regulators controlling the activity of the SUN domain. The model corresponds to CC1 that functions as an activation segment to release CC2-mediated inhibition of the SUN domain. Pssm-ID: 410603 [Multi-domain] Cd Length: 55 Bit Score: 93.63 E-value: 2.40e-23
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| HTH_SUN2 | pfam18580 | SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, ... |
574-632 | 1.60e-07 | |||||
SUN2 helix-turn-helix domain; LINC complexes are formed by coupling of KASH (Klarsicht, ANC-1, and Syne/Nesprin Homology) and SUN (Sad1 and UNC-84) proteins from the inner and outer nuclear membranes (INM and ONM, respectively). the formation of LINC complexes by KASH and SUN proteins at the nuclear envelope (NE) establishes the physical linkage between the cytoskeleton and nuclear lamina, which is instrumental for the mechanical force transmission from the cytoplasm to the nuclear interior, and is essential for cellular processes such as nuclear positioning and migration, centrosome-nucleus anchorage, and chromosome dynamics. This entry represents an HTH domain found in SUN2 that forms a three-helix bundle to lock the SUN domain in an inactive conformation acting as an inhibitory component. Pssm-ID: 436594 [Multi-domain] Cd Length: 58 Bit Score: 48.48 E-value: 1.60e-07
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| CALCOCO1 | pfam07888 | Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ... |
393-566 | 9.69e-04 | |||||
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region. Pssm-ID: 462303 [Multi-domain] Cd Length: 488 Bit Score: 42.57 E-value: 9.69e-04
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