NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1622908614|ref|XP_028700296|]
View 

cytochrome c-like [Macaca mulatta]

Protein Classification

cytochrome c family protein( domain architecture ID 229496)

cytochrome c family protein is a ubiquitous heme protein in mitochondria and bacteria, possessing a CXXCH motif with covalently attached heme; in both prokaryotes and eukaryotes it functions to transfer electrons from reduced substrates to physiological partners, thereby driving the pathway leading to oxidative phosphorylation and ATP synthesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DHOR super family cl21467
Di-haem oxidoreductase, putative peroxidase; DHOR is a family of di-haem oxidoredictases. It ...
 2-104 5.02e-46

Di-haem oxidoreductase, putative peroxidase; DHOR is a family of di-haem oxidoredictases. It carries the two characteriztic Cys-X-Y-Cys-His haem-binding motifs. The C-terminal high-potential site functions as an electron transfer centre, and the N-terminal low-potential site corresponds to the peroxidatic centre. Its probable function is as a peroxidase.


The actual alignment was detected with superfamily member PTZ00048:

Pssm-ID: 473872  Cd Length: 115  Bit Score: 143.84  E-value: 5.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAiGFSYTDAKKNKGITWGQDKLMEYLENPKKYIPGRKT 81
Cdd:PTZ00048   13 GDAKKGAKLFKAKCAQCHTINKGGAVKQGPNLHGFYGRKSGSA-DFPYSDANKNSGIVWSDKHLFEYLVNPKLYIPGTKM 91

                          90       100
                  ....*....|....*....|....
gi 1622908614  82 IFAGIKK-AERADLIGYLKKVTNE 104
Cdd:PTZ00048   92 VFAGIKKeKERADLIAYLKEASSK 115
 
Name Accession Description Interval E-value
PTZ00048 PTZ00048
cytochrome c; Provisional
 2-104 5.02e-46

cytochrome c; Provisional


Pssm-ID: 185414  Cd Length: 115  Bit Score: 143.84  E-value: 5.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAiGFSYTDAKKNKGITWGQDKLMEYLENPKKYIPGRKT 81
Cdd:PTZ00048   13 GDAKKGAKLFKAKCAQCHTINKGGAVKQGPNLHGFYGRKSGSA-DFPYSDANKNSGIVWSDKHLFEYLVNPKLYIPGTKM 91

                          90       100
                  ....*....|....*....|....
gi 1622908614  82 IFAGIKK-AERADLIGYLKKVTNE 104
Cdd:PTZ00048   92 VFAGIKKeKERADLIAYLKEASSK 115
Cyc7 COG3474
Cytochrome c2 [Energy production and conversion];
2-99 2.51e-45

Cytochrome c2 [Energy production and conversion];


Pssm-ID: 442697 [Multi-domain]  Cd Length: 101  Bit Score: 141.56  E-value: 2.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAIGFSYTDAKKNKGITWGQDKLMEYLENPKKYIPGRKT 81
Cdd:COG3474     1 GDAAAGEKLFNRKCAACHSVDGGAGNRVGPNLNGVVGRKAGSVEGFAYSDALKASGLVWDEETLDAWLADPKAFVPGTKM 80

                          90
                  ....*....|....*....
gi 1622908614  82 IFAGIKKAE-RADLIGYLK 99
Cdd:COG3474    81 PFAGLKDPEdRADLIAYLK 99
Cytochrom_C pfam00034
Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and ...
 5-102 3.66e-14

Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.


Pssm-ID: 459641 [Multi-domain]  Cd Length: 89  Bit Score: 62.17  E-value: 3.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   5 EKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAIGFSYTDAKKNKGITWGQdklmeylenpKKYIPGRKTI-F 83
Cdd:pfam00034   1 ARGKKLFAANCAACHGVNGEGAGAGGPDLAGLAARYPGDALGAIRENKHAIGGGGVDR----------AGGPPGTGMPaF 70

                          90
                  ....*....|....*....
gi 1622908614  84 AGIKKAERADLIGYLKKVT 102
Cdd:pfam00034  71 DGLTDEEIADLVAYLLSLS 89
CxxCH_TIGR02603 TIGR02603
putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain ...
 2-45 6.42e-05

putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain limited to very few species but expanded into large paralogous families in some species that conain it. We find it in over 20 copies each in Pirellula sp. strain 1 (phylum Planctomycetes) and Verrucomicrobium spinosum DSM 4136 (phylum Verrucomicrobia), and no matches above trusted cutoff an any other species so far. This domain, about 140 amino acids long, contains an absolutely conserved motif CxxCH, the cytochrome c family heme-binding site signature (PS00190).


Pssm-ID: 274224  Cd Length: 133  Bit Score: 39.26  E-value: 6.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVeKGGKHKTGPNLHGlFARKTGQAI 45
Cdd:TIGR02603   1 GDAARGKAVFAKVCYLCHRI-GGQGVDFGPNLTT-VGTKGKEYL 42
 
Name Accession Description Interval E-value
PTZ00048 PTZ00048
cytochrome c; Provisional
 2-104 5.02e-46

cytochrome c; Provisional


Pssm-ID: 185414  Cd Length: 115  Bit Score: 143.84  E-value: 5.02e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAiGFSYTDAKKNKGITWGQDKLMEYLENPKKYIPGRKT 81
Cdd:PTZ00048   13 GDAKKGAKLFKAKCAQCHTINKGGAVKQGPNLHGFYGRKSGSA-DFPYSDANKNSGIVWSDKHLFEYLVNPKLYIPGTKM 91

                          90       100
                  ....*....|....*....|....
gi 1622908614  82 IFAGIKK-AERADLIGYLKKVTNE 104
Cdd:PTZ00048   92 VFAGIKKeKERADLIAYLKEASSK 115
Cyc7 COG3474
Cytochrome c2 [Energy production and conversion];
2-99 2.51e-45

Cytochrome c2 [Energy production and conversion];


Pssm-ID: 442697 [Multi-domain]  Cd Length: 101  Bit Score: 141.56  E-value: 2.51e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAIGFSYTDAKKNKGITWGQDKLMEYLENPKKYIPGRKT 81
Cdd:COG3474     1 GDAAAGEKLFNRKCAACHSVDGGAGNRVGPNLNGVVGRKAGSVEGFAYSDALKASGLVWDEETLDAWLADPKAFVPGTKM 80

                          90
                  ....*....|....*....
gi 1622908614  82 IFAGIKKAE-RADLIGYLK 99
Cdd:COG3474    81 PFAGLKDPEdRADLIAYLK 99
PTZ00405 PTZ00405
cytochrome c; Provisional
 2-99 1.67e-36

cytochrome c; Provisional


Pssm-ID: 173596  Cd Length: 114  Bit Score: 119.76  E-value: 1.67e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAIGFSYTDAKKNKGITWGQDKLMEYLENPKKYIPGRKT 81
Cdd:PTZ00405   12 GDAERGEKLFKGRAAQCHTATKGGSNGVGPNLFGIVNRKSGTVEGFAYSKANADSGVIWTPEVLDVYLENPKKFMPGTKM 91

                          90
                  ....*....|....*....
gi 1622908614  82 IFAGIKK-AERADLIGYLK 99
Cdd:PTZ00405   92 SFAGIKKpQERADVIAYLE 110
Cytochrom_C pfam00034
Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and ...
 5-102 3.66e-14

Cytochrome c; The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, pfam06181, has now been merged into this family.


Pssm-ID: 459641 [Multi-domain]  Cd Length: 89  Bit Score: 62.17  E-value: 3.66e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908614   5 EKGKKIFVKKCAQCHTVEKGGKHKTGPNLHGLFARKTGQAIGFSYTDAKKNKGITWGQdklmeylenpKKYIPGRKTI-F 83
Cdd:pfam00034   1 ARGKKLFAANCAACHGVNGEGAGAGGPDLAGLAARYPGDALGAIRENKHAIGGGGVDR----------AGGPPGTGMPaF 70

                          90
                  ....*....|....*....
gi 1622908614  84 AGIKKAERADLIGYLKKVT 102
Cdd:pfam00034  71 DGLTDEEIADLVAYLLSLS 89
psbV CHL00133
photosystem II cytochrome c550; Validated
 4-75 8.88e-06

photosystem II cytochrome c550; Validated


Pssm-ID: 177055  Cd Length: 163  Bit Score: 41.98  E-value: 8.88e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622908614   4 VEKGKKIFVKKCAQCHTvekGGKHKTGPNLhGLFARKTGQAigfsyTDAKKNKgitwgqDKLMEYLENPKKY 75
Cdd:CHL00133   52 VKRGKRLFNASCGACHV---GGITKTNPNV-GLDPEALSLA-----TPPRDNI------EALVDYMKNPTTY 108
CxxCH_TIGR02603 TIGR02603
putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain ...
 2-45 6.42e-05

putative heme-binding domain, Pirellula/Verrucomicrobium type; This model represents a domain limited to very few species but expanded into large paralogous families in some species that conain it. We find it in over 20 copies each in Pirellula sp. strain 1 (phylum Planctomycetes) and Verrucomicrobium spinosum DSM 4136 (phylum Verrucomicrobia), and no matches above trusted cutoff an any other species so far. This domain, about 140 amino acids long, contains an absolutely conserved motif CxxCH, the cytochrome c family heme-binding site signature (PS00190).


Pssm-ID: 274224  Cd Length: 133  Bit Score: 39.26  E-value: 6.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622908614   2 GDVEKGKKIFVKKCAQCHTVeKGGKHKTGPNLHGlFARKTGQAI 45
Cdd:TIGR02603   1 GDAARGKAVFAKVCYLCHRI-GGQGVDFGPNLTT-VGTKGKEYL 42
CccA COG2010
Cytochrome c, mono- and diheme variants [Energy production and conversion];
3-35 6.99e-05

Cytochrome c, mono- and diheme variants [Energy production and conversion];


Pssm-ID: 441613 [Multi-domain]  Cd Length: 169  Bit Score: 39.55  E-value: 6.99e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1622908614   3 DVEKGKKIFVKKCAQCHTVEKGGKHKTGPNLHG 35
Cdd:COG2010    88 ALARGKALYEQNCAACHGADGKGGLGAAPNLTD 120
TsdA COG3258
Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion ...
 2-19 2.73e-04

Thiosulfate dehydrogenase TsdA, contains C-terminal cytochrome c domain [Inorganic ion transport and metabolism];


Pssm-ID: 442489 [Multi-domain]  Cd Length: 216  Bit Score: 38.30  E-value: 2.73e-04
                          10
                  ....*....|....*...
gi 1622908614   2 GDVEKGKKIFVKKCAQCH 19
Cdd:COG3258   115 ADVERGKALYAERCASCH 132
Cytochrome_CBB3 pfam13442
Cytochrome C oxidase, cbb3-type, subunit III;
2-35 8.54e-04

Cytochrome C oxidase, cbb3-type, subunit III;


Pssm-ID: 463879 [Multi-domain]  Cd Length: 67  Bit Score: 35.07  E-value: 8.54e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622908614   2 GDVEKGKKIFVKKCAQCHtvekgGKHKTGPNLHG 35
Cdd:pfam13442   1 AAAAAGEALYAANCASCH-----GTGGAGPSLAG 29
CytC553 COG2863
Cytochrome c553 [Energy production and conversion];
2-36 1.31e-03

Cytochrome c553 [Energy production and conversion];


Pssm-ID: 442110 [Multi-domain]  Cd Length: 98  Bit Score: 35.09  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1622908614   2 GDVEKGKKiFVKKCAQCHTVE-KGGKHKTGPNLHGL 36
Cdd:COG2863    13 GDAARGKA-YAAACAACHGADgEGNPGGGAPRLAGQ 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH