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Concise Results
Standard Results
Full Results
Fanconi anemia group D2 protein isoform X7 [Macaca mulatta]
Protein Classification
FANCI/FANCD2 family protein ( domain architecture ID 98588 )
FANCI/FANCD2 family protein similar to Homo sapiens fanconi anemia group I protein (FANCI) and fanconi anemia group D2 protein (FANCD2)
List of domain hits
Name
Accession
Description
Interval
E-value
FancD2 super family
cl48259 Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
39-1301
0e+00
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
pfam14631 :Pssm-ID: 464225
Cd Length: 1346
Bit Score: 2261.96
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 39 YY S K NSD EI N V PRLI VS QLKWLDR V VDGKDLT A K I MQLIS I AP EN LQHDIITSLPEIL G DSQH T DV GK EL rwistlsps N 118
Cdd:pfam14631 129 FE S V NSD GL N M PRLI IN QLKWLDR I VDGKDLT S K L MQLIS V AP VE LQHDIITSLPEIL E DSQH N DV AR EL --------- S 199
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 119 D LL I ENT S LTVPILD V LSSL R LDP NF L LK VRQ L VM DK LS SIR LEDLPV II KFILHS IT A M DA L EVISELR E KLDL QH CVL 198
Cdd:pfam14631 200 S LL V ENT Q LTVPILD A LSSL N LDP TL L SE VRQ A VM GT LS AVQ LEDLPV VV KFILHS VS A T DA Y EVISELR K KLDL EQ CVL 279
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 199 P SR LQASQ V KLKSKG R ASSSGNQ E SS D Q S CI I L L FDVIKSA I R YE KTISEAW I KAIEN TA SVS E HKV F DL V MLFIIYSTN 278
Cdd:pfam14631 280 P PV LQASQ S KLKSKG A ASSSGNQ A SS S Q D CI S L V FDVIKSA V R FQ KTISEAW L KAIEN ID SVS D HKV L DL L MLFIIYSTN 359
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 279 TQT KK Y IERVLRNK I RSGCIQEQLLQSTF SV H Y LVL K D MCS SIL S LAQSLLHS L DQSI I SFGS LL YKYAF KF FD T YCQQE 358
Cdd:pfam14631 360 ANQ KK G IERVLRNK V RSGCIQEQLLQSTF RT H A LVL R D YFP SIL A LAQSLLHS P DQSI V SFGS HM YKYAF TA FD S YCQQE 439
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 359 VVGALVTH I CSGNEAEVD T AL DV LLELVVL N PSAM MMN AVFVKGILDY L DN IS PQQIRKLF YV LSTLAFS K Q N E A SSHIQ 438
Cdd:pfam14631 440 VVGALVTH V CSGNEAEVD V AL EL LLELVVL K PSAM RLY AVFVKGILDY M DN LT PQQIRKLF HI LSTLAFS Q Q H E Q SSHIQ 519
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 439 DDMH L VIRKQLSSTV F KYK L IGIIGAVTM A G I MAADR TE S c SLTQER A N LS N EQC T QVTSLL Q LVHSCSEQSPQA S ALYY 518
Cdd:pfam14631 520 DDMH I VIRKQLSSTV P KYK R IGIIGAVTM V G S MAADR SK S - GSSSQS A S LS K EQC R QVTSLL E LVHSCSEQSPQA A ALYY 598
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 519 DE F ANLIQ QE KLDPK A LE RV G HTICS DFQD A FVVD SCVVP EGDFPFPVKALYGLEE YNT Q D GIAINLLPLL FSQDF AKD G 598
Cdd:pfam14631 599 DE L ANLIQ KG KLDPK V LE WI G QSVLN DFQD D FVVD LGPDI EGDFPFPVKALYGLEE EES Q G GIAINLLPLL AKDEQ AKD E 678
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 599 G P VT P QE S GQK L VSPLCL A P Y FRLLRLCVE R QH N G N LEEIDGLL D CP IF LTDLE P GEKLES M S A KER A F M CSLLF L T L NW 678
Cdd:pfam14631 679 G E VT A QE K GQK R VSPLCL S P F FRLLRLCVE K QH D G D LEEIDGLL G CP LI LTDLE V GEKLES L S K KER E F L CSLLF H T I NW 758
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 679 FRE I VNAFCQ ETS PEMKGKVLTRL KH I V ELQ II LEKYLAVTP D Y I PPL G NFD vetlditphtvtaisakirkkgkierkq 758
Cdd:pfam14631 759 FRE V VNAFCQ QKD PEMKGKVLTRL QN I T ELQ SL LEKYLAVTP G Y V PPL A NFD ---------------------------- 810
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 759 kadgsktss S D TISE E KN SE CDPTP S HRG QL N KEF T GKE E KT SLL L HN YRAFFRELDIEVFS I LHCGL V TK FI LDTEMHT 838
Cdd:pfam14631 811 --------- L D SSQK E EA SE AEESQ S EKS QL E KEF K GKE G KT GVS L QS YRAFFRELDIEVFS V LHCGL L TK SL LDTEMHT 881
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 839 E A T E V VQLGP P ELLFLLEDLS Q KLE S MLTP PI A R R V PF F K N KG S RN I GFSHLQQRSAQEI V HCV F QL VT P M CNHLENIHN 918
Cdd:pfam14631 882 K A R E E VQLGP A ELLFLLEDLS R KLE F MLTP AP A K R A PF L K G KG D RN V GFSHLQQRSAQEI A HCV V QL LP P L CNHLENIHN 961
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 919 YFQCL A AENHGVVDGPG MK VQE YHI MSSCYQ R LLQ IF H G LFAWSGFSQPEN QN LL Y SAL H VL SS RLK Q GE HSQP LEEL L S 998
Cdd:pfam14631 962 YFQCL L AENHGVVDGPG VD VQE HQL MSSCYQ L LLQ VL H T LFAWSGFSQPEN RS LL K SAL G VL AG RLK E GE AELT LEEL V S 1041
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 999 Q SF H YLQNF HQ S I PSFQCAL Y LI R LL M VI L EKS TASTQNK EKIASLARQFLC R VW -- PSG D KEK SSIS ND Q LH A LLCIYL 1076
Cdd:pfam14631 1042 H SF E YLQNF RS S V PSFQCAL C LI Q LL I VI A EKS GNPAAKR EKIASLARQFLC Q VW vt PSG E KEK GNKF ND A LH T LLCIYL 1121
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1077 EHTD SI LKAIEEIAG V GVPELINS P KD V SSSTFPTLTR H TF V VFFRVMMAELEK T V K KI E PGTA A DSQ QIH EEKLLYWNM 1156
Cdd:pfam14631 1122 EHTD DV LKAIEEIAG E GVPELINS S KD A SSSTFPTLTR Q TF L VFFRVMMAELEK S V R KI Q PGTA S DSQ EVQ EEKLLYWNM 1201
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1157 AVRDF S IL I NL I KVFDS H PVLHVCLKYGRLFVEAFLK QC MPLLDFSF R KHREDV L SLL E TFQL D TR L LHH L CGHSKIHQD 1236
Cdd:pfam14631 1202 AVRDF H IL V NL V KVFDS R PVLHVCLKYGRLFVEAFLK LG MPLLDFSF K KHREDV Q SLL K TFQL S TR Q LHH M CGHSKIHQD 1281
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622908537 1237 T R LT Q HVPLLKK T LEL L V C RVKAML T LNNC R EAFWLGNLKNRDLQGEEI K SQ N SQES TAD E S ED D 1301
Cdd:pfam14631 1282 T G LT N HVPLLKK S LEL F V Y RVKAML V LNNC Q EAFWLGNLKNRDLQGEEI L SQ R SQES DEE E E ED S 1346
Name
Accession
Description
Interval
E-value
FancD2
pfam14631 Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
39-1301
0e+00
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Pssm-ID: 464225
Cd Length: 1346
Bit Score: 2261.96
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 39 YY S K NSD EI N V PRLI VS QLKWLDR V VDGKDLT A K I MQLIS I AP EN LQHDIITSLPEIL G DSQH T DV GK EL rwistlsps N 118
Cdd:pfam14631 129 FE S V NSD GL N M PRLI IN QLKWLDR I VDGKDLT S K L MQLIS V AP VE LQHDIITSLPEIL E DSQH N DV AR EL --------- S 199
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 119 D LL I ENT S LTVPILD V LSSL R LDP NF L LK VRQ L VM DK LS SIR LEDLPV II KFILHS IT A M DA L EVISELR E KLDL QH CVL 198
Cdd:pfam14631 200 S LL V ENT Q LTVPILD A LSSL N LDP TL L SE VRQ A VM GT LS AVQ LEDLPV VV KFILHS VS A T DA Y EVISELR K KLDL EQ CVL 279
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 199 P SR LQASQ V KLKSKG R ASSSGNQ E SS D Q S CI I L L FDVIKSA I R YE KTISEAW I KAIEN TA SVS E HKV F DL V MLFIIYSTN 278
Cdd:pfam14631 280 P PV LQASQ S KLKSKG A ASSSGNQ A SS S Q D CI S L V FDVIKSA V R FQ KTISEAW L KAIEN ID SVS D HKV L DL L MLFIIYSTN 359
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 279 TQT KK Y IERVLRNK I RSGCIQEQLLQSTF SV H Y LVL K D MCS SIL S LAQSLLHS L DQSI I SFGS LL YKYAF KF FD T YCQQE 358
Cdd:pfam14631 360 ANQ KK G IERVLRNK V RSGCIQEQLLQSTF RT H A LVL R D YFP SIL A LAQSLLHS P DQSI V SFGS HM YKYAF TA FD S YCQQE 439
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 359 VVGALVTH I CSGNEAEVD T AL DV LLELVVL N PSAM MMN AVFVKGILDY L DN IS PQQIRKLF YV LSTLAFS K Q N E A SSHIQ 438
Cdd:pfam14631 440 VVGALVTH V CSGNEAEVD V AL EL LLELVVL K PSAM RLY AVFVKGILDY M DN LT PQQIRKLF HI LSTLAFS Q Q H E Q SSHIQ 519
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 439 DDMH L VIRKQLSSTV F KYK L IGIIGAVTM A G I MAADR TE S c SLTQER A N LS N EQC T QVTSLL Q LVHSCSEQSPQA S ALYY 518
Cdd:pfam14631 520 DDMH I VIRKQLSSTV P KYK R IGIIGAVTM V G S MAADR SK S - GSSSQS A S LS K EQC R QVTSLL E LVHSCSEQSPQA A ALYY 598
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 519 DE F ANLIQ QE KLDPK A LE RV G HTICS DFQD A FVVD SCVVP EGDFPFPVKALYGLEE YNT Q D GIAINLLPLL FSQDF AKD G 598
Cdd:pfam14631 599 DE L ANLIQ KG KLDPK V LE WI G QSVLN DFQD D FVVD LGPDI EGDFPFPVKALYGLEE EES Q G GIAINLLPLL AKDEQ AKD E 678
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 599 G P VT P QE S GQK L VSPLCL A P Y FRLLRLCVE R QH N G N LEEIDGLL D CP IF LTDLE P GEKLES M S A KER A F M CSLLF L T L NW 678
Cdd:pfam14631 679 G E VT A QE K GQK R VSPLCL S P F FRLLRLCVE K QH D G D LEEIDGLL G CP LI LTDLE V GEKLES L S K KER E F L CSLLF H T I NW 758
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 679 FRE I VNAFCQ ETS PEMKGKVLTRL KH I V ELQ II LEKYLAVTP D Y I PPL G NFD vetlditphtvtaisakirkkgkierkq 758
Cdd:pfam14631 759 FRE V VNAFCQ QKD PEMKGKVLTRL QN I T ELQ SL LEKYLAVTP G Y V PPL A NFD ---------------------------- 810
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 759 kadgsktss S D TISE E KN SE CDPTP S HRG QL N KEF T GKE E KT SLL L HN YRAFFRELDIEVFS I LHCGL V TK FI LDTEMHT 838
Cdd:pfam14631 811 --------- L D SSQK E EA SE AEESQ S EKS QL E KEF K GKE G KT GVS L QS YRAFFRELDIEVFS V LHCGL L TK SL LDTEMHT 881
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 839 E A T E V VQLGP P ELLFLLEDLS Q KLE S MLTP PI A R R V PF F K N KG S RN I GFSHLQQRSAQEI V HCV F QL VT P M CNHLENIHN 918
Cdd:pfam14631 882 K A R E E VQLGP A ELLFLLEDLS R KLE F MLTP AP A K R A PF L K G KG D RN V GFSHLQQRSAQEI A HCV V QL LP P L CNHLENIHN 961
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 919 YFQCL A AENHGVVDGPG MK VQE YHI MSSCYQ R LLQ IF H G LFAWSGFSQPEN QN LL Y SAL H VL SS RLK Q GE HSQP LEEL L S 998
Cdd:pfam14631 962 YFQCL L AENHGVVDGPG VD VQE HQL MSSCYQ L LLQ VL H T LFAWSGFSQPEN RS LL K SAL G VL AG RLK E GE AELT LEEL V S 1041
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 999 Q SF H YLQNF HQ S I PSFQCAL Y LI R LL M VI L EKS TASTQNK EKIASLARQFLC R VW -- PSG D KEK SSIS ND Q LH A LLCIYL 1076
Cdd:pfam14631 1042 H SF E YLQNF RS S V PSFQCAL C LI Q LL I VI A EKS GNPAAKR EKIASLARQFLC Q VW vt PSG E KEK GNKF ND A LH T LLCIYL 1121
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1077 EHTD SI LKAIEEIAG V GVPELINS P KD V SSSTFPTLTR H TF V VFFRVMMAELEK T V K KI E PGTA A DSQ QIH EEKLLYWNM 1156
Cdd:pfam14631 1122 EHTD DV LKAIEEIAG E GVPELINS S KD A SSSTFPTLTR Q TF L VFFRVMMAELEK S V R KI Q PGTA S DSQ EVQ EEKLLYWNM 1201
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1157 AVRDF S IL I NL I KVFDS H PVLHVCLKYGRLFVEAFLK QC MPLLDFSF R KHREDV L SLL E TFQL D TR L LHH L CGHSKIHQD 1236
Cdd:pfam14631 1202 AVRDF H IL V NL V KVFDS R PVLHVCLKYGRLFVEAFLK LG MPLLDFSF K KHREDV Q SLL K TFQL S TR Q LHH M CGHSKIHQD 1281
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622908537 1237 T R LT Q HVPLLKK T LEL L V C RVKAML T LNNC R EAFWLGNLKNRDLQGEEI K SQ N SQES TAD E S ED D 1301
Cdd:pfam14631 1282 T G LT N HVPLLKK S LEL F V Y RVKAML V LNNC Q EAFWLGNLKNRDLQGEEI L SQ R SQES DEE E E ED S 1346
FANCD2
cd11721 Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
44-1289
0e+00
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.
Pssm-ID: 212595
Cd Length: 1161
Bit Score: 1248.36
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 44 SD E I N V PRLI VS Q L KWLD RV VD GK DLT A K IMQ L I S I AP EN LQ HD IITSLPEI L GDSQH T DV GK EL rwistlsps ND LL I E 123
Cdd:cd11721 79 PS E D N L PRLI LN Q F KWLD HI VD SE DLT E K LLE L L S V AP SE LQ KE IITSLPEI I GDSQH E DV AE EL --------- CK LL Q E 149
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 124 N TS LTVPILD V LS S L R L D P NF L LKV R QL V MDK L SSIR LEDLPV II KF I L H SITA MD ALE V IS E LR EK LD LQHCVL PS RL q 203
Cdd:cd11721 150 N SE LTVPILD A LS N L N L S P EL L SEI R EK V LSC L KTVP LEDLPV LV KF L L Q SITA TE ALE I IS K LR KN LD FSPLSD PS SS - 228
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 204 asqvklkskgra S SS GNQES S DQ SC II L LFDV IKSA I R YE K TIS EAWIK A I ENTASVSE HKV F DL VM L F I I YSTN TQTK K 283
Cdd:cd11721 229 ------------ G SS DKSKA S AN SC QS L ILEA IKSA L R FS K LLA EAWIK V I SSIDAPQD HKV I DL IL L L I L YSTN EDKR K 296
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 284 Y IE RV L RN KI R SG C I QEQ LL QST F SV H YL VLKD MCS S I LSLA QS LL H S LDQSIIS FGS L LYK YA FK F FD T Y C QQEVVGAL 363
Cdd:cd11721 297 S IE SL L KK KI K SG F I RTS LL DLA F TG H SQ VLKD YFK S L LSLA DN LL R S AEPVVRE FGS H LYK LL FK H FD R Y Y QQEVVGAL 376
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 364 V THI C SGN EA EVD T ALDVL L EL VVL NP SAMMMN A V F V KGILDYLD NISPQ QIR K LF YV L ST LAFS - KQNEAS S H IQDD M H 442
Cdd:cd11721 377 I THI G SGN SS EVD A ALDVL R EL AEK NP DELLPY A T F I KGILDYLD SLNLK QIR Q LF DI L CH LAFS e RPLSEG S S IQDD L H 456
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 443 LVI RKQLS STVF KYK LI GIIGAVT MAGIM A ADRTE --- SCSLTQERAN L SN E QCT Q VTS LL Q LV H S CSEQ SP Q A S AL Y YD 519
Cdd:cd11721 457 IIV RKQLS NSSP KYK RM GIIGAVT LVKHL A SANSS dda VERSSSNGSS L PD E RLK Q AAN LL E LV L S SCKN SP E A L AL F YD 536
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 520 E F AN L I Q Q E - K LDPK A LE RV G H TI CS DFQ DA FVVD scvvpegdfpfpvkalyg L E E Y ntqdgiainllpllfsqdfakdg 598
Cdd:cd11721 537 E L AN I I S Q A s N LDPK F LE WL G E TI TE DFQ ES FVVD ------------------ L D E T ----------------------- 575
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 599 gpvtpqesgqklv S PLC LA PY FRLLRL CVER Q HN G N L E EID G LL D CP IF L T D L E PG EK LE S M S AKE R AFMCSL LF LTL NW 678
Cdd:cd11721 576 ------------- S SAI LA SL FRLLRL LERS Q QG G S L D EID A LL G CP LV L P D F E VD EK FD S L S TEQ R SVVLDC LF YAI NW 642
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 679 FRE IV NAF CQETSPEM K G KVL T RL KHIV EL QII L E K Y LA V tpdyipplgnfdvetlditphtvtaisakirkkgkierkq 758
Cdd:cd11721 643 FRE VI NAF ATQKDAST K K KVL K RL RNLI EL EGR L S K L LA H ---------------------------------------- 682
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 759 kadgsktsssdtiseeknsecdptpshrgqlnkeftgkeektslllhnyr AF FRELD I EVFS I L HC GLVT KFI L dtem HT 838
Cdd:cd11721 683 -------------------------------------------------- CY FRELD L EVFS L L KS GLVT DTS L ---- EL 708
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 839 EAT E V V Q LGP P EL L FLLEDL SQ KLE SM LT P P IAR R V P FF K n KGSRNI GFS H L Q Q R S AQ E IVHCVFQ L VTPM C N HLE N IHN 918
Cdd:cd11721 709 SEE E G V H LGP K EL R FLLEDL NR KLE HV LT S P KKK R M P LL K - PLKKGQ GFS S L S Q K S PK E VLKALVP L LPHL C K HLE K IHN 787
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 919 Y F Q C L AAE N H G VV D G PG MK VQE YHIMS SCY QR LLQ IFHG LFAW S GFS QPE N QN LL Y SAL HVLS SRLK QGEHS - Q PL E EL L 997
Cdd:cd11721 788 Y L Q N L LLS N A G QL D A PG PF VQE NQYAK SCY GL LLQ CLRL LFAW P GFS SQS N RV LL K SAL RAIA SRLK ESTGK d L PL K EL V 867
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 998 S QS F H YL QN F HQ S I PS FQC A LY L IR LL MVIL EKS TAST Q NK EK I A S LAR Q FLCR V WP -- SG DK EK SSIS ND QLHA LL C IY 1075
Cdd:cd11721 868 S SL F K YL KS F EP S V PS LST A VS L VQ LL QALM EKS PDRP Q LR EK L A D LAR N FLCR Q WP dl SG ES EK GQKY ND LIDT LL R IY 947
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1076 LEH T D SI LK AI EEIAG VGV PEL INSP KD VS - SS TFPTL TRH TF VV FFRV M M AE L EKT VKKI EPG t AAD SQQIHE E K LL Y W 1154
Cdd:cd11721 948 LEH S D DP LK KL EEIAG EAL PEL LEKK KD KD a LE TFPTL SKS TF PI FFRV L M EA L IES VKKI LSS - AAD TGGGEM E R LL L W 1026
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1155 NM AVR D F SI L I NL I K V FD SH PVL HV CLKYGRLF VEA FLK QC MPLL DFS F RK H R E D V LS LL E T F Q LD TR L LHH L C G HSKIH 1234
Cdd:cd11721 1027 QS AVR V F KA L V NL V K T FD KR PVL AI CLKYGRLF LKL FLK LG MPLL EKL F KN H K E E V QE LL K T L Q QS TR Y LHH I C C HSKIH 1106
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*
gi 1622908537 1235 Q DT R LT Q HVP L LKK T LE L LV C RVKAML TL NNC R EAFW L GNLKN R DLQGEEI K SQ N 1289
Cdd:cd11721 1107 K DT A LT N HVP A LKK S LE T LV Y RVKAML VA NNC S EAFW M GNLKN K DLQGEEI L SQ R 1161
Name
Accession
Description
Interval
E-value
FancD2
pfam14631 Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease ...
39-1301
0e+00
Fanconi anaemia protein FancD2 nuclease; The Fanconi anaemia protein FancD2 is a nuclease necessary for the repair of DNA interstrand-crosslinks.
Pssm-ID: 464225
Cd Length: 1346
Bit Score: 2261.96
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 39 YY S K NSD EI N V PRLI VS QLKWLDR V VDGKDLT A K I MQLIS I AP EN LQHDIITSLPEIL G DSQH T DV GK EL rwistlsps N 118
Cdd:pfam14631 129 FE S V NSD GL N M PRLI IN QLKWLDR I VDGKDLT S K L MQLIS V AP VE LQHDIITSLPEIL E DSQH N DV AR EL --------- S 199
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 119 D LL I ENT S LTVPILD V LSSL R LDP NF L LK VRQ L VM DK LS SIR LEDLPV II KFILHS IT A M DA L EVISELR E KLDL QH CVL 198
Cdd:pfam14631 200 S LL V ENT Q LTVPILD A LSSL N LDP TL L SE VRQ A VM GT LS AVQ LEDLPV VV KFILHS VS A T DA Y EVISELR K KLDL EQ CVL 279
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 199 P SR LQASQ V KLKSKG R ASSSGNQ E SS D Q S CI I L L FDVIKSA I R YE KTISEAW I KAIEN TA SVS E HKV F DL V MLFIIYSTN 278
Cdd:pfam14631 280 P PV LQASQ S KLKSKG A ASSSGNQ A SS S Q D CI S L V FDVIKSA V R FQ KTISEAW L KAIEN ID SVS D HKV L DL L MLFIIYSTN 359
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 279 TQT KK Y IERVLRNK I RSGCIQEQLLQSTF SV H Y LVL K D MCS SIL S LAQSLLHS L DQSI I SFGS LL YKYAF KF FD T YCQQE 358
Cdd:pfam14631 360 ANQ KK G IERVLRNK V RSGCIQEQLLQSTF RT H A LVL R D YFP SIL A LAQSLLHS P DQSI V SFGS HM YKYAF TA FD S YCQQE 439
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 359 VVGALVTH I CSGNEAEVD T AL DV LLELVVL N PSAM MMN AVFVKGILDY L DN IS PQQIRKLF YV LSTLAFS K Q N E A SSHIQ 438
Cdd:pfam14631 440 VVGALVTH V CSGNEAEVD V AL EL LLELVVL K PSAM RLY AVFVKGILDY M DN LT PQQIRKLF HI LSTLAFS Q Q H E Q SSHIQ 519
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 439 DDMH L VIRKQLSSTV F KYK L IGIIGAVTM A G I MAADR TE S c SLTQER A N LS N EQC T QVTSLL Q LVHSCSEQSPQA S ALYY 518
Cdd:pfam14631 520 DDMH I VIRKQLSSTV P KYK R IGIIGAVTM V G S MAADR SK S - GSSSQS A S LS K EQC R QVTSLL E LVHSCSEQSPQA A ALYY 598
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 519 DE F ANLIQ QE KLDPK A LE RV G HTICS DFQD A FVVD SCVVP EGDFPFPVKALYGLEE YNT Q D GIAINLLPLL FSQDF AKD G 598
Cdd:pfam14631 599 DE L ANLIQ KG KLDPK V LE WI G QSVLN DFQD D FVVD LGPDI EGDFPFPVKALYGLEE EES Q G GIAINLLPLL AKDEQ AKD E 678
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 599 G P VT P QE S GQK L VSPLCL A P Y FRLLRLCVE R QH N G N LEEIDGLL D CP IF LTDLE P GEKLES M S A KER A F M CSLLF L T L NW 678
Cdd:pfam14631 679 G E VT A QE K GQK R VSPLCL S P F FRLLRLCVE K QH D G D LEEIDGLL G CP LI LTDLE V GEKLES L S K KER E F L CSLLF H T I NW 758
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 679 FRE I VNAFCQ ETS PEMKGKVLTRL KH I V ELQ II LEKYLAVTP D Y I PPL G NFD vetlditphtvtaisakirkkgkierkq 758
Cdd:pfam14631 759 FRE V VNAFCQ QKD PEMKGKVLTRL QN I T ELQ SL LEKYLAVTP G Y V PPL A NFD ---------------------------- 810
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 759 kadgsktss S D TISE E KN SE CDPTP S HRG QL N KEF T GKE E KT SLL L HN YRAFFRELDIEVFS I LHCGL V TK FI LDTEMHT 838
Cdd:pfam14631 811 --------- L D SSQK E EA SE AEESQ S EKS QL E KEF K GKE G KT GVS L QS YRAFFRELDIEVFS V LHCGL L TK SL LDTEMHT 881
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 839 E A T E V VQLGP P ELLFLLEDLS Q KLE S MLTP PI A R R V PF F K N KG S RN I GFSHLQQRSAQEI V HCV F QL VT P M CNHLENIHN 918
Cdd:pfam14631 882 K A R E E VQLGP A ELLFLLEDLS R KLE F MLTP AP A K R A PF L K G KG D RN V GFSHLQQRSAQEI A HCV V QL LP P L CNHLENIHN 961
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 919 YFQCL A AENHGVVDGPG MK VQE YHI MSSCYQ R LLQ IF H G LFAWSGFSQPEN QN LL Y SAL H VL SS RLK Q GE HSQP LEEL L S 998
Cdd:pfam14631 962 YFQCL L AENHGVVDGPG VD VQE HQL MSSCYQ L LLQ VL H T LFAWSGFSQPEN RS LL K SAL G VL AG RLK E GE AELT LEEL V S 1041
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 999 Q SF H YLQNF HQ S I PSFQCAL Y LI R LL M VI L EKS TASTQNK EKIASLARQFLC R VW -- PSG D KEK SSIS ND Q LH A LLCIYL 1076
Cdd:pfam14631 1042 H SF E YLQNF RS S V PSFQCAL C LI Q LL I VI A EKS GNPAAKR EKIASLARQFLC Q VW vt PSG E KEK GNKF ND A LH T LLCIYL 1121
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1077 EHTD SI LKAIEEIAG V GVPELINS P KD V SSSTFPTLTR H TF V VFFRVMMAELEK T V K KI E PGTA A DSQ QIH EEKLLYWNM 1156
Cdd:pfam14631 1122 EHTD DV LKAIEEIAG E GVPELINS S KD A SSSTFPTLTR Q TF L VFFRVMMAELEK S V R KI Q PGTA S DSQ EVQ EEKLLYWNM 1201
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1157 AVRDF S IL I NL I KVFDS H PVLHVCLKYGRLFVEAFLK QC MPLLDFSF R KHREDV L SLL E TFQL D TR L LHH L CGHSKIHQD 1236
Cdd:pfam14631 1202 AVRDF H IL V NL V KVFDS R PVLHVCLKYGRLFVEAFLK LG MPLLDFSF K KHREDV Q SLL K TFQL S TR Q LHH M CGHSKIHQD 1281
1210 1220 1230 1240 1250 1260
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622908537 1237 T R LT Q HVPLLKK T LEL L V C RVKAML T LNNC R EAFWLGNLKNRDLQGEEI K SQ N SQES TAD E S ED D 1301
Cdd:pfam14631 1282 T G LT N HVPLLKK S LEL F V Y RVKAML V LNNC Q EAFWLGNLKNRDLQGEEI L SQ R SQES DEE E E ED S 1346
FANCD2
cd11721 Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi ...
44-1289
0e+00
Fanconi anemia D2 protein; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome. The phosphorylation of FANCD2 is required for DNA damage-induced intra-S phase checkpoint and for cellular resistance to DNA crosslinking agents.
Pssm-ID: 212595
Cd Length: 1161
Bit Score: 1248.36
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 44 SD E I N V PRLI VS Q L KWLD RV VD GK DLT A K IMQ L I S I AP EN LQ HD IITSLPEI L GDSQH T DV GK EL rwistlsps ND LL I E 123
Cdd:cd11721 79 PS E D N L PRLI LN Q F KWLD HI VD SE DLT E K LLE L L S V AP SE LQ KE IITSLPEI I GDSQH E DV AE EL --------- CK LL Q E 149
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 124 N TS LTVPILD V LS S L R L D P NF L LKV R QL V MDK L SSIR LEDLPV II KF I L H SITA MD ALE V IS E LR EK LD LQHCVL PS RL q 203
Cdd:cd11721 150 N SE LTVPILD A LS N L N L S P EL L SEI R EK V LSC L KTVP LEDLPV LV KF L L Q SITA TE ALE I IS K LR KN LD FSPLSD PS SS - 228
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 204 asqvklkskgra S SS GNQES S DQ SC II L LFDV IKSA I R YE K TIS EAWIK A I ENTASVSE HKV F DL VM L F I I YSTN TQTK K 283
Cdd:cd11721 229 ------------ G SS DKSKA S AN SC QS L ILEA IKSA L R FS K LLA EAWIK V I SSIDAPQD HKV I DL IL L L I L YSTN EDKR K 296
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 284 Y IE RV L RN KI R SG C I QEQ LL QST F SV H YL VLKD MCS S I LSLA QS LL H S LDQSIIS FGS L LYK YA FK F FD T Y C QQEVVGAL 363
Cdd:cd11721 297 S IE SL L KK KI K SG F I RTS LL DLA F TG H SQ VLKD YFK S L LSLA DN LL R S AEPVVRE FGS H LYK LL FK H FD R Y Y QQEVVGAL 376
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 364 V THI C SGN EA EVD T ALDVL L EL VVL NP SAMMMN A V F V KGILDYLD NISPQ QIR K LF YV L ST LAFS - KQNEAS S H IQDD M H 442
Cdd:cd11721 377 I THI G SGN SS EVD A ALDVL R EL AEK NP DELLPY A T F I KGILDYLD SLNLK QIR Q LF DI L CH LAFS e RPLSEG S S IQDD L H 456
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 443 LVI RKQLS STVF KYK LI GIIGAVT MAGIM A ADRTE --- SCSLTQERAN L SN E QCT Q VTS LL Q LV H S CSEQ SP Q A S AL Y YD 519
Cdd:cd11721 457 IIV RKQLS NSSP KYK RM GIIGAVT LVKHL A SANSS dda VERSSSNGSS L PD E RLK Q AAN LL E LV L S SCKN SP E A L AL F YD 536
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 520 E F AN L I Q Q E - K LDPK A LE RV G H TI CS DFQ DA FVVD scvvpegdfpfpvkalyg L E E Y ntqdgiainllpllfsqdfakdg 598
Cdd:cd11721 537 E L AN I I S Q A s N LDPK F LE WL G E TI TE DFQ ES FVVD ------------------ L D E T ----------------------- 575
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 599 gpvtpqesgqklv S PLC LA PY FRLLRL CVER Q HN G N L E EID G LL D CP IF L T D L E PG EK LE S M S AKE R AFMCSL LF LTL NW 678
Cdd:cd11721 576 ------------- S SAI LA SL FRLLRL LERS Q QG G S L D EID A LL G CP LV L P D F E VD EK FD S L S TEQ R SVVLDC LF YAI NW 642
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 679 FRE IV NAF CQETSPEM K G KVL T RL KHIV EL QII L E K Y LA V tpdyipplgnfdvetlditphtvtaisakirkkgkierkq 758
Cdd:cd11721 643 FRE VI NAF ATQKDAST K K KVL K RL RNLI EL EGR L S K L LA H ---------------------------------------- 682
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 759 kadgsktsssdtiseeknsecdptpshrgqlnkeftgkeektslllhnyr AF FRELD I EVFS I L HC GLVT KFI L dtem HT 838
Cdd:cd11721 683 -------------------------------------------------- CY FRELD L EVFS L L KS GLVT DTS L ---- EL 708
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 839 EAT E V V Q LGP P EL L FLLEDL SQ KLE SM LT P P IAR R V P FF K n KGSRNI GFS H L Q Q R S AQ E IVHCVFQ L VTPM C N HLE N IHN 918
Cdd:cd11721 709 SEE E G V H LGP K EL R FLLEDL NR KLE HV LT S P KKK R M P LL K - PLKKGQ GFS S L S Q K S PK E VLKALVP L LPHL C K HLE K IHN 787
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 919 Y F Q C L AAE N H G VV D G PG MK VQE YHIMS SCY QR LLQ IFHG LFAW S GFS QPE N QN LL Y SAL HVLS SRLK QGEHS - Q PL E EL L 997
Cdd:cd11721 788 Y L Q N L LLS N A G QL D A PG PF VQE NQYAK SCY GL LLQ CLRL LFAW P GFS SQS N RV LL K SAL RAIA SRLK ESTGK d L PL K EL V 867
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 998 S QS F H YL QN F HQ S I PS FQC A LY L IR LL MVIL EKS TAST Q NK EK I A S LAR Q FLCR V WP -- SG DK EK SSIS ND QLHA LL C IY 1075
Cdd:cd11721 868 S SL F K YL KS F EP S V PS LST A VS L VQ LL QALM EKS PDRP Q LR EK L A D LAR N FLCR Q WP dl SG ES EK GQKY ND LIDT LL R IY 947
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1076 LEH T D SI LK AI EEIAG VGV PEL INSP KD VS - SS TFPTL TRH TF VV FFRV M M AE L EKT VKKI EPG t AAD SQQIHE E K LL Y W 1154
Cdd:cd11721 948 LEH S D DP LK KL EEIAG EAL PEL LEKK KD KD a LE TFPTL SKS TF PI FFRV L M EA L IES VKKI LSS - AAD TGGGEM E R LL L W 1026
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1155 NM AVR D F SI L I NL I K V FD SH PVL HV CLKYGRLF VEA FLK QC MPLL DFS F RK H R E D V LS LL E T F Q LD TR L LHH L C G HSKIH 1234
Cdd:cd11721 1027 QS AVR V F KA L V NL V K T FD KR PVL AI CLKYGRLF LKL FLK LG MPLL EKL F KN H K E E V QE LL K T L Q QS TR Y LHH I C C HSKIH 1106
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|....*
gi 1622908537 1235 Q DT R LT Q HVP L LKK T LE L LV C RVKAML TL NNC R EAFW L GNLKN R DLQGEEI K SQ N 1289
Cdd:cd11721 1107 K DT A LT N HVP A LKK S LE T LV Y RVKAML VA NNC S EAFW M GNLKN K DLQGEEI L SQ R 1161
FANC
cd11719 Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of ...
44-1166
0e+00
Fanconi anemia ID complex proteins FANCI and FANCD2; The Fanconi anemia ID complex consists of two subunits, Fanconi anemia I and Fanconi anemia D2 (FANCI-FANCD2) and plays a central role in the repair of DNA interstrand cross-links (ICLs). The complex is activated via DNA damage-induced phosphorylation by ATR (ataxia telangiectasia and Rad3-related) and monoubiquitination by the FA core complex ubiquitin ligase, and it binds to DNA at the ICL site, recognizing branched DNA structures. Defects in the complex cause Fanconi anemia, a cancer predisposition syndrome.
Pssm-ID: 212593
Cd Length: 977
Bit Score: 963.23
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 44 S D EINVPRLIVSQLKWLDRVVDGK DL TAKIMQLISIAPENLQHDIITSLPEILG ----------------- DSQHTDVGK 106
Cdd:cd11719 43 Q D VASEIIGLLMLEVHHFPGPLLV DL ASDFVGAVREDRLVNGKSLELLPIILTA latkkevlacgkgdlng EEYKRQLID 122
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 107 E L rwistlspsn DLLIENTSLTVPILD V LSSLR L D P NFLLK V RQL V MDKL S SIR L EDL P VIIKFI L HS --- ITAMDA L EV 183
Cdd:cd11719 123 T L ---------- CSVRWPQRYMIQLTS V FKDVC L T P EEMNL V VAK V LTMF S KLN L QEI P PLVYQL L VL ssk GSRRSV L DG 192
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 184 I SELREK LD L QH CVLP S RLQA sqvklkskgr ASSSGNQESSDQSCIILLFDV I KS AI RYE - KTIS E AWIKAIE -- NTASV 260
Cdd:cd11719 193 I IAFFRE LD K QH REEQ S SDEL ---------- SELITAPADELYHVEGTVILH I VF AI KLD c ELGR E LLKHLKA gq QGDPS 262
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 261 SEHKV F DLVM L FIIYSTNTQTKKYIERVLRNKIR S GC ------------------- IQEQLLQSTFSVHYLVLKDMCSSI 321
Cdd:cd11719 263 KCLCP F SIAL L LSLTRIQRFEEQVFDLLKTSVVK S FK dlqllqgskflqtlvpqrt CVSTMILEVVRNSVHSWDHVTQGL 342
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 322 LSLAQS L LH S L --------------------- D Q SIISF G SLLYKYA FK f FDTYCQ QE VVGALVTHICSGNEAEVDTA LD 380
Cdd:cd11719 343 IEFGFI L MD S Y gpkkildgkaveigtslskmt N Q HACKL G ANILLET FK - IHEMIR QE ILEQVLNRVVTRTSSPINHF LD 421
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 381 VLLELVVLN P SA m MM N AVF V KGIL DYL DNISP Q QIRK L FYVLST L AFSK qneas SHIQ D DMH LV I RK QLSSTVFKYKLIG 460
Cdd:cd11719 422 LFSDIIMYA P LI - LQ N CSK V TETF DYL TFLPL Q TVQG L LKAVQP L LKIS ----- MSMR D SLI LV L RK AMFASQLDARKSA 495
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 461 II G AVTMAGIMAADRT ------------ ESCSLTQERANLSNEQC T QVTSLLQLVHSCSE Q SPQASALY YD E fanliqq E 528
Cdd:cd11719 496 VA G FLLLLKNFKVLGS lpssqctqsigv TQVRVDVHSRYSAVANE T FCLEIIDSLKRSLG Q QADIRLML YD G ------- F 568
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 529 KLDPKALERVGHT I CSDFQDAFVVDSCVV P EGDF P FPVK A lygleeyntqdgiainllpllfsqdfakdggpv TPQES G Q 608
Cdd:cd11719 569 YDVLRRNSQLASS I MQTLFSQLKQFYEPE P DLLP P LKLG A --------------------------------- CVLTQ G S 615
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 609 KLVSPLC L APYFRLLRL C VERQ hngnleeidglldcpifltdlepgeklesmsakerafmcsllfl TLNWFREIVNAFCQ 688
Cdd:cd11719 616 QIFLQEP L DHLLSCIQH C LAWY -------------------------------------------- ACLIMGVCEVLMEY 651
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 689 ET S PE ----- MKGKV L TRLKHIVELQI I lekylavtpdyipplgnfdvetlditphtvtaisakirkkgkierkqkadgs 763
Cdd:cd11719 652 NF S IS nfsks KFEEI L SLFTCYKKFSD I ---------------------------------------------------- 679
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 764 ktsssdtiseeknsecdptpshrgqlnkeftgkeektslllhnyraffrel DIEVFSILHCG L VTKFILDT --- E MHTEA 840
Cdd:cd11719 680 --------------------------------------------------- IFQNLCDITRV L LWRYTSIP tsv E ESGKK 708
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 841 TEVVQLGPPE L LF L LEDL S QK L ES mltppiarrvpffknkgsrnigfshlqqrsaqe IVHC V F Q LV -------------- 906
Cdd:cd11719 709 EKGKSISLLC L EG L QKTF S VV L QF --------------------------------- YQPK V Q Q FL qaldvmgteeeeag 755
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 907 --- T PMCNHLENIHNYFQCLAAENHGV vdgpgmk VQEYHIMSSCYQR L LQIFHG L FA wsgfsqpenqnllysalhvlssr 983
Cdd:cd11719 756 vtv T QRASFQIRQFQRSLLNLLSSEED ------- DFNSKEALLLIAV L STLSRL L EP ----------------------- 805
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 984 lkqgehsqpleel L S QS F HYLQNFHQ ---------- SIPSFQCALYLIR L LMVILE kstastqnkeki ASLARQF L CRVW 1053
Cdd:cd11719 806 ------------- T S PQ F VQMLSWTS kickeysqed ASFCKSLMNLFFS L HVLYKS ------------ PVTLLRD L SQDI 860
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1054 PSGDK ----------------- EKSSISNDQLHAL L CIYLE ht DSI L KAIEEIAGVG V PE linspkdvss STFPTLTRH T 1116
Cdd:cd11719 861 HGQLG didqdveiektdhfavv NLRTAAPTVCLLV L SQAEK -- VMQ L GTLVTFFHEL V QT ---------- ALPSGSCVD T 928
1210 1220 1230 1240 1250
....*....|....*....|....*....|....*....|....*....|
gi 1622908537 1117 FVVFFRVMMAE L EKT VK KIEPGT a AD S QQ I HEEKLLYWNMAVRDFSILIN 1166
Cdd:cd11719 929 LLKGLSKIYST L TAF VK YYLQVC - QS S RG I PNTVEKLVKLSGSHLTPVCY 977
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
