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Conserved domains on  [gi|1622899609|ref|XP_028698884|]
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importin subunit alpha-5 isoform X1 [Macaca mulatta]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
25-455 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 568.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609  25 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIV 104
Cdd:COG5064    75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVV 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 105 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKS 183
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKN 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 184 PPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:COG5064   234 PPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIV 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 264 TGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 343
Cdd:COG5064   314 TGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAI 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 344 TNATSGGS--AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE 421
Cdd:COG5064   394 SNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIH 473

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1622899609 422 FLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQ 455
Cdd:COG5064   474 GLQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPE 507
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
25-455 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 568.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609  25 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIV 104
Cdd:COG5064    75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVV 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 105 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKS 183
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKN 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 184 PPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:COG5064   234 PPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIV 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 264 TGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 343
Cdd:COG5064   314 TGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAI 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 344 TNATSGGS--AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE 421
Cdd:COG5064   394 SNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIH 473

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1622899609 422 FLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQ 455
Cdd:COG5064   474 GLQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 410-455 8.98e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 79.56  E-value: 8.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622899609 410 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 455
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-136 1.35e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.20  E-value: 1.35e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622899609   97 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 136
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
25-455 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 568.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609  25 DMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTpGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIV 104
Cdd:COG5064    75 QLTQQLFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDA-GVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVV 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 105 IQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLF-SKQNRLTMTRNAVWALSNLCRGKS 183
Cdd:COG5064   154 VDAGAVPLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlSSAIHISMLRNATWTLSNLCRGKN 233

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 184 PPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:COG5064   234 PPPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIV 313

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 264 TGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAI 343
Cdd:COG5064   314 TGSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAI 393

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 344 TNATSGGS--AEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIE 421
Cdd:COG5064   394 SNATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEQDRLRYGKNINIYAVYVEKAGGMDAIH 473

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1622899609 422 FLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQ 455
Cdd:COG5064   474 GLQDSVNRTIYDKAYSIIEKFFGEEDAVDELAPE 507
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 410-455 8.98e-19

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 79.56  E-value: 8.98e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622899609 410 LIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDE--DSSIAPQ 455
Cdd:pfam16186   2 LIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEedDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-136 1.41e-11

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 59.01  E-value: 1.41e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622899609  97 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 136
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 97-136 1.35e-09

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 53.20  E-value: 1.35e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622899609   97 NSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIA 136
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 308-348 7.27e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.60  E-value: 7.27e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622899609 308 NRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATS 348
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
107-262 1.04e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.78  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 107 AGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTmcrdyvldcniLPPLLQLFSKQNRLTmTRNAVWALSNLcrgKSPpp 186
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGDPRA-----------VPALLEALKDPDPEV-RAAAAEALGRI---GDP-- 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622899609 187 efAKVSPCLNVLSWllfvSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 262
Cdd:COG1413    78 --EAVPALIAALKD----EDPEVRRAAAEALGRLGD------PAAVPA-----LLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-180 1.23e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 1.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1622899609 139 STMCRDYVLDCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 180
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPD-EEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 224-264 2.86e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 46.68  E-value: 2.86e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622899609 224 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVT 264
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 351-391 5.92e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.92e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1622899609 351 SAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILR 391
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 224-263 1.10e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.11  E-value: 1.10e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622899609  224 PNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIV 263
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 82-135 8.31e-06

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 43.12  E-value: 8.31e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622899609  82 LQFESAWVLTNIASGNSLQTRIVIQAgAVPIFIELLSSEFEDVQEQAVWALGNI 135
Cdd:pfam13513   3 VREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 67-176 1.14e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.48  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609  67 VARFVEFLKRKENCTLQFESAWVLTNIASgnslqtriviqAGAVPIFIELLSSEFEDVQEQAVWALGNIaGDSTMcrdyv 146
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI-GDPEA----- 63

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622899609 147 ldcniLPPLLQLFSKQNRLTMTRNAVWALS 176
Cdd:pfam13646  64 -----LPALLELLRDDDDDVVRAAAAEALA 88
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 308-348 1.56e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.65  E-value: 1.56e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1622899609  308 NRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATS 348
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 351-389 2.18e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 41.26  E-value: 2.18e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1622899609  351 SAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENI 389
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 139-180 2.31e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 38.56  E-value: 2.31e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1622899609  139 STMCRDYVLDCNILPPLLQLFSKQNrLTMTRNAVWALSNLCR 180
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
169-343 4.39e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 4.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 169 RNAVWALSNLcrgkspppefaKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHND 248
Cdd:COG1413     3 RAAARALGRL-----------GDPAAVPALIAALADEDPDVRAAAARALGRLGD------PRAVPA-----LLEALKDPD 60

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 249 YKVVSPALRAVGNIvtGDDIQTQVILNcsalqsllhLLSSPKESIKKEACWTISNITagnraqiqtviDANIFPALISIL 328
Cdd:COG1413    61 PEVRAAAAEALGRI--GDPEAVPALIA---------ALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEAL 118

                         170
                  ....*....|....*
gi 1622899609 329 QTAEFRTRKEAAWAI 343
Cdd:COG1413   119 KDPDWEVRRAAARAL 133
HEAT COG1413
HEAT repeat [General function prediction only];
124-262 5.06e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 5.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622899609 124 VQEQAVWALGNIAGDSTmcrdyvldcniLPPLLQLFSKQNRLTMtRNAVWALSNLCRGKSPPPefakvspclnvLSWLLF 203
Cdd:COG1413     1 VRRAAARALGRLGDPAA-----------VPALIAALADEDPDVR-AAAARALGRLGDPRAVPA-----------LLEALK 57

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622899609 204 VSDTDVLADACWALSYLSDgpndkiQAVIDAgvcrrLVELLMHNDYKVVSPALRAVGNI 262
Cdd:COG1413    58 DPDPEVRAAAAEALGRIGD------PEAVPA-----LIAALKDEDPEVRRAAAEALGRL 105
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 183-222 1.59e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 1.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622899609 183 SPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSD 222
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 53-95 2.41e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.41e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622899609  53 PNPPIDEVIStPGVVARFVEFLKrKENCTLQFESAWVLTNIAS 95
Cdd:pfam00514   1 SPENKQAVIE-AGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 21-43 2.45e-03

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 36.75  E-value: 2.45e-03
                          10        20
                  ....*....|....*....|...
gi 1622899609  21 VITSDMIEMIFSKSPEQQLSATQ 43
Cdd:pfam01749  57 ESLPEMVQGVNSDDPELQLEATQ 79
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 292-345 5.66e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.04  E-value: 5.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622899609 292 SIKKEACWTISNITAGNRAQIQTVIDaNIFPALISILQTAEFRTRKEAAWAITN 345
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVP-ELLPALLPLLNDDSDLVREAAAWALGR 54
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 124-178 7.31e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 34.65  E-value: 7.31e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622899609 124 VQEQAVWALGNIAGDSTM-CRDYVLDcnILPPLLQLfSKQNRLTMTRNAVWALSNL 178
Cdd:pfam13513   3 VREAAALALGSLAEGGPDlLAPAVPE--LLPALLPL-LNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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