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Conserved domains on  [gi|1622917075|ref|XP_028697444|]
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pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial isoform X4 [Macaca mulatta]

Protein Classification

GcvT family protein( domain architecture ID 11429831)

GcvT (glycine cleavage system T) family protein similar to mammalian dimethylglycine dehydrogenase that catalyzes the FAD-dependent demethylation of N,N-dimethylglycine to sarcosine, and pyruvate dehydrogenase phosphatase regulatory subunit

CATH:  3.30.1360.120|3.30.70.140|3.30.70.1400|3.30.9.10|2.40.30.110
PubMed:  8219277
SCOP:  4000128|4000062

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 354-752 8.46e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 276.58  E-value: 8.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 354 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 433
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 434 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 512
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 513 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 592
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 593 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGmDFIGRDALLLQKQNGVYKRLTMFIL 672
Cdd:COG0404   215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 673 DDHDTdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 752
Cdd:COG0404   294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-319 1.70e-55

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 194.74  E-value: 1.70e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHV 80
Cdd:COG0665    63 LAREALDLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGlsNEEPVSIPL 160
Cdd:COG0665   143 PDDGHVDPAKLVRALARAARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 161 HACEHFYLLTRPLETPLqssTPTIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSS 238
Cdd:COG0665   221 RPVRGYVLVTEPLPDLP---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRR 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 239 LLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLK 318
Cdd:COG0665   284 LRRLFPALADAEIVRAWAGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPD 363


                  .
gi 1622917075 319 R 319
Cdd:COG0665   364 R 364
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 305-360 8.37e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.10  E-value: 8.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622917075 305 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 360
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 354-752 8.46e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 276.58  E-value: 8.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 354 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 433
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 434 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 512
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 513 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 592
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 593 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGmDFIGRDALLLQKQNGVYKRLTMFIL 672
Cdd:COG0404   215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 673 DDHDTdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 752
Cdd:COG0404   294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 363-636 6.24e-85

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 269.84  E-value: 6.24e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 363 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 442
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 443 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 521
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 522 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYG 601
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAELG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1622917075 602 IRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECG 636
Cdd:pfam01571 216 LRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAG 250
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-319 1.70e-55

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 194.74  E-value: 1.70e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHV 80
Cdd:COG0665    63 LAREALDLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGlsNEEPVSIPL 160
Cdd:COG0665   143 PDDGHVDPAKLVRALARAARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 161 HACEHFYLLTRPLETPLqssTPTIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSS 238
Cdd:COG0665   221 RPVRGYVLVTEPLPDLP---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRR 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 239 LLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLK 318
Cdd:COG0665   284 LRRLFPALADAEIVRAWAGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPD 363


                  .
gi 1622917075 319 R 319
Cdd:COG0665   364 R 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 1-302 4.07e-39

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 148.31  E-value: 4.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRlISLKRINSRLNVIGIPSEIISPKKVAELHHLLNvhDLVGAMHV 80
Cdd:pfam01266  61 LALEALDLWEELEEELGIDCGFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFY 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVmVKKGQVTGVETDkGQIECqyFVNCAGQWAYELGLSneePVSIPL 160
Cdd:pfam01266 138 PDGGHVDPARLLRALARAAEALGVRIIEGTEVTGI-EEEGGVWGVVTT-GEADA--VVNAAGAWADLLALP---GLRLPV 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 161 HACEHFYLLTRPL-ETPLQSSTPTIVDADGRIYIRN-WQGGILSGGFEknpkpiFTEGKNQLEIqnlqeDWDHFEPLLSS 238
Cdd:pfam01266 211 RPVRGQVLVLEPLpEALLILPVPITVDPGRGVYLRPrADGRLLLGGTD------EEDGFDDPTP-----DPEEIEELLEA 279

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622917075 239 LLRRMPELETLEimklvncpETF-----TPDMRCIMGEsPAVQGYFVLAGMNSAGLSFGGGAGKYLAEW 302
Cdd:pfam01266 280 ARRLFPALADIE--------RAWaglrpLPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
357-738 1.97e-37

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 143.72  E-value: 1.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 357 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppdkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 435
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 436 stGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMI--SPTDQQVhcWAWLKKHMpKDSNL 512
Cdd:PRK00389   59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 513 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPSLFCKEMSVGYANGIRVmSMT-HTGEPGFMLYIPIEYALHVYN 591
Cdd:PRK00389  134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEDAEALWD 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 592 EVMSVGqkygIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLLQKQNGVYKRLTMF- 670
Cdd:PRK00389  211 ALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLe 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 671 -----IlddhdtdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVhnfSEDTGEE------------QVVTAD 733
Cdd:PRK00389  287 leergI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV---PAGVGDEveveirgkqvpaKVVKPP 352


                  ....*
gi 1622917075 734 FINRG 738
Cdd:PRK00389  353 FVRRG 357
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 305-360 8.37e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.10  E-value: 8.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622917075 305 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 360
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 1-320 1.22e-04

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 45.21  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTgYTRTGSIFLAQTQDRliSLKRINSRLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHV 80
Cdd:TIGR01377  60 MMLECYQLWAQLEKEAGTKL-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYEL--GLSNEEPVSi 158
Cdd:TIGR01377 137 PNGGVLYAEKALRALQELAEAHGATVRDGTKVVEIEPTELLVT-VKTTKGSYQANKLVVTAGAWTSKLlsPLGIEIPLQ- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 159 PLHACEHFYLLTRPLETPLQSSTPTIV--DADGRIYirnwqgGILSGGFEKNPKPIFTEGKN----------QLEIQNLQ 226
Cdd:TIGR01377 215 PLRINVCYWREKEPGSYGVSQAFPCFLvlGLNPHIY------GLPSFEYPGLMKVYYHHGQQidpderdcpfGADIEDVQ 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 227 EdwdhfeplLSSLLR-RMPEL-ETLEIMKLvnCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMV 304
Cdd:TIGR01377 289 I--------LRKFVRdHLPGLnGEPKKGEV--CMYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAM 358

                         330
                  ....*....|....*.
gi 1622917075 305 HGYPSENVWELDLKRF 320
Cdd:TIGR01377 359 KLKPSYDLAIFSLNRF 374
solA PRK11259
N-methyl-L-tryptophan oxidase;
8-322 3.71e-04

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 43.67  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   8 LYHQLEQETGiQTGYTRTGSIFLAQTQDRLISlkrinsrlNVI------GIPSEIISPKKVAELHHLLNVHDlvGAMHV- 80
Cdd:PRK11259   71 LWRELERESG-EPLFVRTGVLNLGPADSDFLA--------NSIrsarqhGLPHEVLDAAEIRRRFPQFRLPD--GYIALf 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 --------PEDAVVSSADVALalasaasQNGVQIYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYELgLSn 152
Cdd:PRK11259  140 epdggflrPELAIKAHLRLAR-------EAGAELLFNEPVTAIEADGDGVT-VTTADGTYEAKKLVVSAGAWVKDL-LP- 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 153 eePVSIPLHACEH-FYLLTRPLETPLQSSTPtivdadgrIYIRNWQGGILSGGFEKNPKPIFTEGKNQ--LEIQNLQE-- 227
Cdd:PRK11259  210 --PLELPLTPVRQvLAWFQADGRYSEPNRFP--------AFIWEVPDGDQYYGFPAENGPGLKIGKHNggQEITSPDErd 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 228 ---DWDHFEPLLSSLLRR-MPELETLeiMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWM 303
Cdd:PRK11259  280 rfvTVAEDGAELRPFLRNyLPGVGPC--LRGAACTYTNTPDEHFIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLA 357

                         330
                  ....*....|....*....
gi 1622917075 304 VHGYPSENVWELDLKRFGA 322
Cdd:PRK11259  358 QDGTSDFDLSPFSLSRFAA 376
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 354-752 8.46e-86

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 276.58  E-value: 8.46e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 354 GRQLRTSPLYDRLDAQGARWMEKHGFERPKYFVppdkdllaleqsktfykpdwfDIVESEVKCCKEAVCVIDMSSFTKFE 433
Cdd:COG0404     1 FRPLRRTPLHDRHVALGAKFVDFGGWEMPVQYP---------------------GGVIAEHLAVREAVGLFDVSHMGKIE 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 434 ITstGDQALEVLQYLFSNDLDV-PVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDSNL 512
Cdd:COG0404    60 VT--GPDAAAFLDRLVTNDVSKlKPGRARYTLMLNEDGGIIDDLTVYRLGEDRFLLVVNAANAAKDLAWLEEHLPPDFDV 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 513 LLEDVTWKYTALNLIGPRAVDVLSELsyAPMTPDHFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNE 592
Cdd:COG0404   138 TITDVTDDWALLAVQGPKAREVLAKL--TDADLSALPFMSFREGTVAGVP-VRVSRTGYTGEDGFEIYVPAEDAEALWDA 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 593 VMSVGQKYGIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGmDFIGRDALLLQKQNGVYKRLTMFIL 672
Cdd:COG0404   215 LLEAGEEFGVKPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKG-DFIGKEALLRQKEEGPRRKLVGLEL 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 673 DDHDTdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEeqvvtadfinrgEYEIDIAGYRFQAK 752
Cdd:COG0404   294 DGRGV-----PRAGAPVLADGEVVGEVTSGTFSPTLGKSIALAYVPAGLARPGT------------ELEVEIRGKRVPAE 356
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 363-636 6.24e-85

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 269.84  E-value: 6.24e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 363 YDRLDAQGARWMEKHGFERPKYFVPPDKDllaleqsktfykpdwfdiveSEVKCCKEAVCVIDMSSFTKFEITstGDQAL 442
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQYGSNGIL--------------------AEHRAVREAAGLFDVSHMGKIEVS--GPDAA 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 443 EVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMISPTDQQVHCWAWLKKHMPKDsNLLLEDVTWKY 521
Cdd:pfam01571  59 AFLQRLTTNDVSkLKPGRATYTLMLNERGGVIDDLTVYRLGDDHFLLVVNAANREKDLAWLRKHAEKL-DVVVVDVTDDY 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 522 TALNLIGPRAVDVLSELSYAPMTPDhFPSLFCKEMSVGYANgIRVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKYG 601
Cdd:pfam01571 138 ALLALQGPKAREVLEKLTDGDLLEA-LPFFSFREIEIGGVP-VRVSRTGYTGEDGFEIYVPAEDAVELWEALLEAGAELG 215

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1622917075 602 IRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECG 636
Cdd:pfam01571 216 LRPAGLGARDSLRLEAGLPLYGHDLDEETTPLEAG 250
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
1-319 1.70e-55

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 194.74  E-value: 1.70e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHV 80
Cdd:COG0665    63 LAREALDLWRELAAELGIDCDFRRTGVLYLARTEAELAALRAEAEALRALGLPVELLDAAELREREPGLGSPDYAGGLYD 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYELGlsNEEPVSIPL 160
Cdd:COG0665   143 PDDGHVDPAKLVRALARAARAAGVRIREGTPVTGLEREGGRVTGVRTERGTVRADAVVLAAGAWSARLL--PMLGLRLPL 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 161 HACEHFYLLTRPLETPLqssTPTIVDaDGRIYIRNWQGG--ILSGGFEKNPkpiftegknqleiQNLQEDWDHFEPLLSS 238
Cdd:COG0665   221 RPVRGYVLVTEPLPDLP---LRPVLD-DTGVYLRPTADGrlLVGGTAEPAG-------------FDRAPTPERLEALLRR 283

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 239 LLRRMPELETLEIMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMVHGYPSENVWELDLK 318
Cdd:COG0665   284 LRRLFPALADAEIVRAWAGLRPMTPDGLPIIGRLPGAPGLYVATGHGGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPD 363


                  .
gi 1622917075 319 R 319
Cdd:COG0665   364 R 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 1-302 4.07e-39

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 148.31  E-value: 4.07e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRlISLKRINSRLNVIGIPSEIISPKKVAELHHLLNvhDLVGAMHV 80
Cdd:pfam01266  61 LALEALDLWEELEEELGIDCGFRRCGVLVLARDEEE-EALEKLLAALRRLGVPAELLDAEELRELEPLLP--GLRGGLFY 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVmVKKGQVTGVETDkGQIECqyFVNCAGQWAYELGLSneePVSIPL 160
Cdd:pfam01266 138 PDGGHVDPARLLRALARAAEALGVRIIEGTEVTGI-EEEGGVWGVVTT-GEADA--VVNAAGAWADLLALP---GLRLPV 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 161 HACEHFYLLTRPL-ETPLQSSTPTIVDADGRIYIRN-WQGGILSGGFEknpkpiFTEGKNQLEIqnlqeDWDHFEPLLSS 238
Cdd:pfam01266 211 RPVRGQVLVLEPLpEALLILPVPITVDPGRGVYLRPrADGRLLLGGTD------EEDGFDDPTP-----DPEEIEELLEA 279

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1622917075 239 LLRRMPELETLEimklvncpETF-----TPDMRCIMGEsPAVQGYFVLAGMNSAGLSFGGGAGKYLAEW 302
Cdd:pfam01266 280 ARRLFPALADIE--------RAWaglrpLPDGLPIIGR-PGSPGLYLATGHGGHGLTLAPGIGKLLAEL 339
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
357-738 1.97e-37

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 143.72  E-value: 1.97e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 357 LRTSPLYDRLDAQGARWMEKHGFERP-KYfvppdkdllaleQSktfykpdwfdIVEsEVKCCKEAVCVIDMSSFTKFEIT 435
Cdd:PRK00389    2 LKRTPLYDLHVALGAKMVDFGGWEMPvQY------------GS----------IIE-EHHAVRTDAGLFDVSHMGEVDVT 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 436 stGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFMI--SPTDQQVhcWAWLKKHMpKDSNL 512
Cdd:PRK00389   59 --GPDALAFLQYLLANDVSkLKPGKAQYTCMLNEDGGVIDDLIVYKLSEDEYLLVvnAANREKD--LAWIKSHA-AGFGV 133

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 513 LLEDVTWKYTALNLIGPRAVDVLSELSYAPMtpDHFPSLFCKEMSVGYANGIRVmSMT-HTGEPGFMLYIPIEYALHVYN 591
Cdd:PRK00389  134 EVTDRSDDLAMIAVQGPKAREKLQKLTDADL--SELKPFFGAQGAEVGGGDVLV-ARTgYTGEDGFEIYLPAEDAEALWD 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 592 EVMSVGqkygIRNAGYYALRSLRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLLQKQNGVYKRLTMF- 670
Cdd:PRK00389  211 ALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTVKLEEKRDFIGREALEAQKEAGVERKLVGLe 286

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 671 -----IlddhdtdldlwPWWGEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVhnfSEDTGEE------------QVVTAD 733
Cdd:PRK00389  287 leergI-----------PRHGYPVLADGEEIGEVTSGTFSPTLGKSIALAYV---PAGVGDEveveirgkqvpaKVVKPP 352


                  ....*
gi 1622917075 734 FINRG 738
Cdd:PRK00389  353 FVRRG 357
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 305-360 8.37e-16

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 72.10  E-value: 8.37e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622917075 305 HGYPSENVWELDLKRFGALQSSRTFLRHRVMEVMPLMYDLKVPRWDFQTGRQLRTS 360
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPHQNNREYLRERVAENYGEVYDIHHPNEEREAGRPLRTS 56
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
355-739 3.11e-14

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 75.17  E-value: 3.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 355 RQLRTSPLYDRLDAQGARwmekhGFerpkyfvppdkdllaleqskTFYK----PDWFDIVESEVKCCKEAVCVIDMSSFT 430
Cdd:PRK12486    9 RRLRRTPFSDGVEAAGVK-----AY--------------------TVYNhmllPTVFESVEDDYAHLKEHVQVWDVAVER 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 431 KFEITstGDQALEVLQYLFSNDLD-VPVGHIVHTGMLNEGGGYENDCSIARLNKRSFFmISPTDQQVHCWAwlkKHMPKD 509
Cdd:PRK12486   64 QVEIR--GPDAARLVQMLTPRDLRgMKPGQCYYVPIVDETGGMLNDPVALKLAEDRWW-ISIADSDLLLWV---KGLANG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 510 SNLLLEDVTWKYTALNLIGPRAVDVLSELSYAPMTPDHFpslfckeMSVGYAN--GIRvMSMTHTG---EPGFMLYIP-I 583
Cdd:PRK12486  138 RKLDVLVVEPDVSPLAVQGPKADALMARVFGEAIRDLRF-------FRFGYFDfeGTD-LVIARSGyskQGGFEIYVEgS 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 584 EYALHVYNEVMSVGQKYGIRnAGYYALRSlRIEKFFAFWGQDINNLTTPLECGRESRVKLEKGMDFIGRDALLLQKQNGV 663
Cdd:PRK12486  210 DLGMPLWDALFEAGKDLNVR-AGCPNLIE-RIEGGLLSYGNDMTRDNTPHECGLGRFCNTQTDIGCIGKDALLRVAKEGP 287

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622917075 664 YKRLTMFILDDHDTDLDLWPWwgePIYRNGQYVGKTTSSAYSYSLERHVCLGFVHNFSEDTGEE-QVVTADFINRGE 739
Cdd:PRK12486  288 QKQIRGIKIGGERIPPCDRAW---PLLAGDNRVGQVTSAAYSPDFQTNVAIGMVRMTHWDPGTGlEVETPDGMRPAT 361
PLN02319 PLN02319
aminomethyltransferase
 463-717 1.75e-12

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 70.14  E-value: 1.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 463 TGML----NEGGGYENDCSIARLNKRSFFMI-----SPTDQqvhcwAWLKKHMpKDSNLLLEDVTW----KYTALNLIGP 529
Cdd:PLN02319  112 TGTLsvftNEKGGIIDDTVITKVTDDHIYLVvnagcRDKDL-----AHIEEHM-KAFKAKGGDVSWhvhdERSLLALQGP 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 530 RAVDVLSELSYAPMTPDHFpSLFcKEMSVgyaNGI--RVMSMTHTGEPGFMLYIPIEYALHVYNEVMSVGQKyGIRNAGY 607
Cdd:PLN02319  186 LAAPVLQHLTKEDLSKMYF-GDF-RITDI---NGAdcFLTRTGYTGEDGFEISVPSEHAVDLAKALLEKSEG-KVRLTGL 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 608 YALRSLRIEKFFAFWGQDINNLTTPLECGRE----SRVKlEKGmDFIGRDALLLQKQNGVYKRLTMFILDdhdtdldlwp 683
Cdd:PLN02319  260 GARDSLRLEAGLCLYGNDLEEHITPVEAGLAwtigKRRR-AEG-GFLGADVILKQLKEGVSRRRVGFISS---------- 327

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1622917075 684 wwGEP------IY-RNGQYVGKTTSSAYSYSLERHVCLGFV 717
Cdd:PLN02319  328 --GAParshseILdESGEKIGEVTSGGFSPCLKKNIAMGYV 366
LhgO COG0579
L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];
6-145 2.90e-12

L-2-hydroxyglutarate oxidase LhgO [Carbohydrate transport and metabolism];


Pssm-ID: 440344 [Multi-domain]  Cd Length: 418  Bit Score: 69.40  E-value: 2.90e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   6 NKLYHQLEQETGIQtgYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPS-EIISPKKVAELHHLLNvHDLVGAMHVPEDA 84
Cdd:COG0579    72 NELFYELCRELGIP--FKRCGKLVVATGEEEVAFLEKLYERGKANGVPGlEILDREELRELEPLLS-DEGVAALYSPSTG 148

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622917075  85 VVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWA 145
Cdd:COG0579   149 IVDPGALTRALAENAEANGVELLLNTEVTGIEREGDGWE-VTTNGGTIRARFVINAAGLYA 208
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 686-752 5.47e-11

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 59.03  E-value: 5.47e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622917075 686 GEPIYRNGQYVGKTTSSAYSYSLERHVCLGFVHnfsedtgeeqvvtADFINRG-EYEIDIAGYRFQAK 752
Cdd:pfam08669  18 GEPVLRDGEVVGYVTSGAYSPTLGKSIALAYVD-------------AELAKPGtEVEVEIRGKRVPAT 72
gcvT PRK13579
glycine cleavage system aminomethyltransferase GcvT;
434-717 1.44e-08

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 237435 [Multi-domain]  Cd Length: 370  Bit Score: 57.65  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 434 ITSTGDQALEVLQYLFSND-LDVPVGHIVHTGMLNEGGGYENDCSIARLNKRsFFMISPTDQQVHCWAWLKKHMPKDSNL 512
Cdd:PRK13579   63 IEVSGKDAAAALERLVPVDiLALKEGRQRYTFFTNEQGGILDDLMVTNLGDH-LFLVVNAACKDADIAHLREHLSDECEV 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 513 -LLEDvtwkYTALNLIGPRAVDVLSELSyapmtPDHFPSLFckeMSVGyanGIRVMSMT-------HTGEPGFMLYIPIE 584
Cdd:PRK13579  142 nPLDD----RALLALQGPEAEAVLADLG-----PPVAALRF---MDGF---EPRLHGVDcfvsrsgYTGEDGFEISVPAD 206

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 585 YA------LHVYNEVMSVGqkYGIRNagyyalrSLRIEKFFAFWGQDINNLTTPLECGRE---SRVKLEKGmDFIGRDAL 655
Cdd:PRK13579  207 AAealaeaLLADPRVEPIG--LGARD-------SLRLEAGLCLYGHDIDTTTTPVEAALEwaiQKARREAG-GFPGAKAI 276

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622917075 656 LLQKQNGV-YKRLTMFILDDHDTDLdlwpwwGEPIYRN-GQYVGKTTSSAYSYSLERHVCLGFV 717
Cdd:PRK13579  277 LAALAKGAsRRRVGLKPEGRAPVRE------GAPLFDDaGTEIGTVTSGGFGPSVGGPVAMGYV 334
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 1-320 1.22e-04

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 45.21  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTgYTRTGSIFLAQTQDRliSLKRINSRLNVIGIPSEIISPKKVAELHHLLNVHDLVGAMHV 80
Cdd:TIGR01377  60 MMLECYQLWAQLEKEAGTKL-HRQTGLLLLGPKENQ--FLKTIQATLSRHGLEHELLSSKQLKQRFPNIRVPRNEVGLLD 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 PEDAVVSSADVALALASAASQNGVQIYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYEL--GLSNEEPVSi 158
Cdd:TIGR01377 137 PNGGVLYAEKALRALQELAEAHGATVRDGTKVVEIEPTELLVT-VKTTKGSYQANKLVVTAGAWTSKLlsPLGIEIPLQ- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 159 PLHACEHFYLLTRPLETPLQSSTPTIV--DADGRIYirnwqgGILSGGFEKNPKPIFTEGKN----------QLEIQNLQ 226
Cdd:TIGR01377 215 PLRINVCYWREKEPGSYGVSQAFPCFLvlGLNPHIY------GLPSFEYPGLMKVYYHHGQQidpderdcpfGADIEDVQ 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 227 EdwdhfeplLSSLLR-RMPEL-ETLEIMKLvnCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWMV 304
Cdd:TIGR01377 289 I--------LRKFVRdHLPGLnGEPKKGEV--CMYTNTPDEHFVIDLHPKYDNVVIGAGFSGHGFKLAPVVGKILAELAM 358

                         330
                  ....*....|....*.
gi 1622917075 305 HGYPSENVWELDLKRF 320
Cdd:TIGR01377 359 KLKPSYDLAIFSLNRF 374
solA PRK11259
N-methyl-L-tryptophan oxidase;
8-322 3.71e-04

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 43.67  E-value: 3.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   8 LYHQLEQETGiQTGYTRTGSIFLAQTQDRLISlkrinsrlNVI------GIPSEIISPKKVAELHHLLNVHDlvGAMHV- 80
Cdd:PRK11259   71 LWRELERESG-EPLFVRTGVLNLGPADSDFLA--------NSIrsarqhGLPHEVLDAAEIRRRFPQFRLPD--GYIALf 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  81 --------PEDAVVSSADVALalasaasQNGVQIYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAGQWAYELgLSn 152
Cdd:PRK11259  140 epdggflrPELAIKAHLRLAR-------EAGAELLFNEPVTAIEADGDGVT-VTTADGTYEAKKLVVSAGAWVKDL-LP- 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 153 eePVSIPLHACEH-FYLLTRPLETPLQSSTPtivdadgrIYIRNWQGGILSGGFEKNPKPIFTEGKNQ--LEIQNLQE-- 227
Cdd:PRK11259  210 --PLELPLTPVRQvLAWFQADGRYSEPNRFP--------AFIWEVPDGDQYYGFPAENGPGLKIGKHNggQEITSPDErd 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075 228 ---DWDHFEPLLSSLLRR-MPELETLeiMKLVNCPETFTPDMRCIMGESPAVQGYFVLAGMNSAGLSFGGGAGKYLAEWM 303
Cdd:PRK11259  280 rfvTVAEDGAELRPFLRNyLPGVGPC--LRGAACTYTNTPDEHFIIDTLPGHPNVLVASGCSGHGFKFASVLGEILADLA 357

                         330
                  ....*....|....*....
gi 1622917075 304 VHGYPSENVWELDLKRFGA 322
Cdd:PRK11259  358 QDGTSDFDLSPFSLSRFAA 376
PRK00711 PRK00711
D-amino acid dehydrogenase;
1-193 8.55e-04

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 42.48  E-value: 8.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075   1 MADYSNKLYHQLEQETGIQTGYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPSEIISPKKVAELH-HLLNV-HDLVGAM 78
Cdd:PRK00711  111 LAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIAVLEEAGVPYELLDRDELAAVEpALAGVrHKLVGGL 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  79 HVPEDAV-------VSSADvalalasAASQNGVQIYDRTSVLHVMVKKGQVTGVETDKGQIECQYFVNCAGQWAYEL--G 149
Cdd:PRK00711  191 RLPNDETgdcqlftQRLAA-------MAEQLGVKFRFNTPVDGLLVEGGRITGVQTGGGVITADAYVVALGSYSTALlkP 263

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1622917075 150 LSNEEPVsIPLHAcehfYLLTRPLETPLQSSTPTIVDADGRIYI 193
Cdd:PRK00711  264 LGVDIPV-YPLKG----YSLTVPITDEDRAPVSTVLDETYKIAI 302
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
14-142 4.68e-03

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 40.19  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622917075  14 QETGIqtGYTRTGSIFLAQTQDRLISLKRINSRLNVIGIPSEIISPKKVAELHHllNVHDLvGAMHVPEDAVVSSADVAL 93
Cdd:PRK11728   79 DQHGI--PYEECGKLLVATSELELERMEALYERARANGIEVERLDAEELREREP--NIRGL-GAIFVPSTGIVDYRAVAE 153

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1622917075  94 ALASAASQNGVQIYDRTSVLHVMVKKGQVTgVETDKGQIECQYFVNCAG 142
Cdd:PRK11728  154 AMAELIQARGGEIRLGAEVTALDEHANGVV-VRTTQGEYEARTLINCAG 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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