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Conserved domains on  [gi|1622912417|ref|XP_028696646|]
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coronin-1A [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-461 7.40e-117

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 351.50  E-value: 7.40e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417   9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNAPTVCGHTAPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVIMVWDVGTGAAV 167
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 168 LTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAEKDrPHEGTRPVRAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421  162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421  239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 327 LEVNKCEIARFYKLHERRCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421  317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 405 RVNRGLDTgRRRAAPEASGT----------------------PSSDAVSRLEEE-----MRKLQATVQELQKR---LDRL 454
Cdd:PTZ00421  394 ELMGASAL-SPSGKPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRC 472


                  ....*..
gi 1622912417 455 EETVQAK 461
Cdd:PTZ00421  473 REALQKK 479
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 7.40e-117

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 351.50  E-value: 7.40e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417   9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNAPTVCGHTAPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVIMVWDVGTGAAV 167
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 168 LTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAEKDrPHEGTRPVRAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421  162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421  239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 327 LEVNKCEIARFYKLHERRCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421  317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 405 RVNRGLDTgRRRAAPEASGT----------------------PSSDAVSRLEEE-----MRKLQATVQELQKR---LDRL 454
Cdd:PTZ00421  394 ELMGASAL-SPSGKPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRC 472


                  ....*..
gi 1622912417 455 EETVQAK 461
Cdd:PTZ00421  473 REALQKK 479
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.87e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 1.87e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622912417   4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-302 1.18e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  76 TVCGHTAPVLDIAWCPHnDNVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNV 155
Cdd:cd00200    46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 156 IMVWDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAEkdrpHEG-TRPVRAVFVS--EG 232
Cdd:cd00200   117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVAFSpdGE 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622912417 233 KILTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200   191 KLLSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
WD40 COG2319
WD40 repeat [General function prediction only];
79-303 2.69e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIMV 158
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 159 WDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAekdRPHEGTRPVRAVFVS-EGKILTT 237
Cdd:COG2319   189 WDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSpDGRLLAS 263

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622912417 238 GfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVyLCGKGDSSIRYFEITSEAPF 303
Cdd:COG2319   264 G---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLL 323
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 2.93e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.93e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622912417   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-461 7.40e-117

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 351.50  E-value: 7.40e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417   9 SKFRHVFGQPAKADQCYEDVRVSQTTWD-SGFCAVNPKFVALICEASGGGAflVLPLGKTGRVDKNAPTVCGHTAPVLDI 87
Cdd:PTZ00421    4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTA--VLKHTDYGKLASNPPILLGQEGPIIDV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  88 AWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVIMVWDVGTGAAV 167
Cdd:PTZ00421   82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 168 LTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAEKDrPHEGTRPVRAVFVSEGK-ILTTGFSRMSERQ 246
Cdd:PTZ00421  162 EVI--KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVE-AHASAKSQRCLWAKRKDlIITLGCSKSQQRQ 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 247 VALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRG 326
Cdd:PTZ00421  239 IMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMPKWS 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 327 LEVNKCEIARFYKLHERRCEPIAMTVPRK-SDL-FQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYvppKSREL 404
Cdd:PTZ00421  317 LDTRKCEIARFYALTYHSLYTIQMLLPRKqADSeLQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVF---DGTSP 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 405 RVNRGLDTgRRRAAPEASGT----------------------PSSDAVSRLEEE-----MRKLQATVQELQKR---LDRL 454
Cdd:PTZ00421  394 ELMGASAL-SPSGKPRHSGVsvpastsamthsfddntskhadPCAMGVKRMDEGilderLGRLQALSEKLRTQheeIKRC 472


                  ....*..
gi 1622912417 455 EETVQAK 461
Cdd:PTZ00421  473 REALQKK 479
PTZ00420 PTZ00420
coronin; Provisional
 18-394 6.03e-69

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 229.45  E-value: 6.03e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  18 PAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRvdkNAPTVC--GHTAPVLDIAWCPHNDN 95
Cdd:PTZ00420   12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR---KPPVIKlkGHTSSILDLQFNPCFSE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  96 VIASGSEDCTVMVWEIP-DGGLVLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGCDNVIMVWDVGTGAAVLTLgpeV 174
Cdd:PTZ00420   89 ILASGSEDLTIRVWEIPhNDESVKEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQI---N 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 175 HPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKcTVVAEKDRPHEGTRPVRAVFV-----SEGKILTTGFSRMSERQVAL 249
Cdd:PTZ00420  166 MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRK-QEIASSFHIHDGGKNTKNIWIdglggDDNYILSTGFSKNNMREMKL 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 250 WDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEApfLHYLSMFSSKESQRGMGYMPKRGLEV 329
Cdd:PTZ00420  245 WDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGFLPKQICDV 322

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622912417 330 NKCEIARFYK-LHERRCEPIAMTVPRK-SDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKD 394
Cdd:PTZ00420  323 YKCEIGRVYKnENNSSIRPISFYVPRKnPTKFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKD 389
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.87e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 1.87e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622912417   4 QVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGR 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-302 1.18e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 1.18e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  76 TVCGHTAPVLDIAWCPHnDNVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNV 155
Cdd:cd00200    46 TLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLWDLETG-------ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 156 IMVWDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAEkdrpHEG-TRPVRAVFVS--EG 232
Cdd:cd00200   117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVAT----LTGhTGEVNSVAFSpdGE 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1622912417 233 KILTTGfsrmSERQVALWDTKhleeplSLQELDTSSGVLLPF----FDPDTNIVyLCGKGDSSIRYFEITSEAP 302
Cdd:cd00200   191 KLLSSS----SDGTIKLWDLS------TGKCLGTLRGHENGVnsvaFSPDGYLL-ASGSEDGTIRVWDLRTGEC 253
Trimer_CC pfam08954
trimerization motif; This domain is predominantly found in the structural protein coronin, and ...
 410-461 7.56e-30

trimerization motif; This domain is predominantly found in the structural protein coronin, and is duplicated in some sequences. It appears to have the function of stabilising the topology of short coiled-coils in proteins.


Pssm-ID: 462646  Cd Length: 52  Bit Score: 110.40  E-value: 7.56e-30
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1622912417 410 LDTGRRRAAPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK 461
Cdd:pfam08954   1 LDSGRRRATPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK 52
WD40 COG2319
WD40 repeat [General function prediction only];
79-303 2.69e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 2.69e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIMV 158
Cdd:COG2319   118 GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATG-------KLLRTLTGHSGAVTSVAFSPDGK-LLASGSDDGTVRL 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 159 WDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKCTVVAekdRPHEGTRPVRAVFVS-EGKILTT 237
Cdd:COG2319   189 WDLATGKLLRTL--TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSpDGRLLAS 263

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622912417 238 GfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIVyLCGKGDSSIRYFEITSEAPF 303
Cdd:COG2319   264 G---SADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLL 323
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-238 1.68e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 102.80  E-value: 1.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  79 GHTAPVLDIAWCPHNDnVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTAQNvLLSAGCDNVIMV 158
Cdd:cd00200   133 GHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTG-------KCVATLTGHTGEVNSVAFSPDGEK-LLSSSSDGTIKL 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 159 WDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRI--IEPRKCTVVAEKdrpHEGtrPVRAVFVS-EGKIL 235
Cdd:cd00200   204 WDLSTGKCLGTL--RGHENGVNSVAFSPDGYLLASGSEDGTIRVwdLRTGECVQTLSG---HTN--SVTSLAWSpDGKRL 276


                  ...
gi 1622912417 236 TTG 238
Cdd:cd00200   277 ASG 279
WD40 COG2319
WD40 repeat [General function prediction only];
79-202 5.23e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.45  E-value: 5.23e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIMV 158
Cdd:COG2319   286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATG-------KLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRL 356

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622912417 159 WDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:COG2319   357 WDLATGELLRTL--TGHTGAVTSVAFSPDGRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 79-202 5.53e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 5.53e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGglvlplrEPVVTLEGHTKRVGIVAWHPTaQNVLLSAGCDNVIMV 158
Cdd:cd00200   175 GHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG-------KCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1622912417 159 WDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:cd00200   246 WDLRTGECVQTL--SGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 6.48e-20

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 82.56  E-value: 6.48e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1622912417 345 CEPIAMTVPRKS-DLFQEDLYPPTAGPDPALTAEEWLGGRDAGP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-299 1.78e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 1.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 126 TLEGHTKRVGIVAWHPTaQNVLLSAGCDNVIMVWDVGTGAAVLTLgpEVHPDTIYSVDWSRDGGLICTSCRDKRVRI--I 203
Cdd:cd00200     4 TLKGHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGSSDKTIRLwdL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 204 EPRKCTVVAEkdrPHEGtrPVRAV-FVSEGKILTTGfsrMSERQVALWDTKHLEEPLSLQelDTSSGVLLPFFDPDTNIV 282
Cdd:cd00200    81 ETGECVRTLT---GHTS--YVSSVaFSPDGRILSSS---SRDKTIKVWDVETGKCLTTLR--GHTDWVNSVAFSPDGTFV 150

                         170
                  ....*....|....*..
gi 1622912417 283 YlCGKGDSSIRYFEITS 299
Cdd:cd00200   151 A-SSSQDGTIKLWDLRT 166
WD40 COG2319
WD40 repeat [General function prediction only];
79-163 1.49e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 1.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417  79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWEIPDGGLVLplrepvvTLEGHTKRVGIVAWHPTAQnVLLSAGCDNVIMV 158
Cdd:COG2319   328 GHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLR-------TLTGHTGAVTSVAFSPDGR-TLASGSADGTVRL 398


                  ....*
gi 1622912417 159 WDVGT 163
Cdd:COG2319   399 WDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 79-110 2.93e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.93e-07
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1622912417   79 GHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:smart00320  10 GHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 121-160 1.53e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.53e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1622912417  121 REPVVTLEGHTKRVGIVAWHPTaQNVLLSAGCDNVIMVWD 160
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
76-110 3.07e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 3.07e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622912417  76 TVCGHTAPVLDIAWCPhNDNVIASGSEDCTVMVWE 110
Cdd:pfam00400   6 TLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
121-160 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.26e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1622912417 121 REPVVTLEGHTKRVGIVAWHPTaQNVLLSAGCDNVIMVWD 160
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 76-110 2.20e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 2.20e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1622912417  76 TVCGHTAPVLDIAWCPHNdNVIASGSEDCTVMVWE 110
Cdd:cd00200   256 TLSGHTNSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 175-202 2.94e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.94e-04
                           10        20
                   ....*....|....*....|....*...
gi 1622912417  175 HPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKL 38
WD40 COG2319
WD40 repeat [General function prediction only];
116-262 4.12e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 4.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 116 LVLPLREPVVTLEGHTKRVGIVAWHPTAQNVLLSAGcDNVIMVWDVGTGAAVLTLGPevHPDTIYSVDWSRDGGLICTSC 195
Cdd:COG2319    21 LAAALGALLLLLLGLAAAVASLAASPDGARLAAGAG-DLTLLLLDAAAGALLATLLG--HTAAVLSVAFSPDGRLLASAS 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622912417 196 RDKRVRI--IEPRKCTVVaekDRPHEGtrPVRAVFVS-EGKILTTGFsrmSERQVALWDTKHLEEPLSLQ 262
Cdd:COG2319    98 ADGTVRLwdLATGLLLRT---LTGHTG--AVRSVAFSpDGKTLASGS---ADGTVRLWDLATGKLLRTLT 159
WD40 pfam00400
WD domain, G-beta repeat;
175-202 6.30e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 6.30e-04
                          10        20
                  ....*....|....*....|....*...
gi 1622912417 175 HPDTIYSVDWSRDGGLICTSCRDKRVRI 202
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKV 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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