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Conserved domains on  [gi|1622896448|ref|XP_028695289|]
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zinc finger protein 30 isoform X5 [Macaca mulatta]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-535 7.52e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 7.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 177 KPFVCEECGKAFSTFSYLIQHQRIHTGEKPYEC--KECGKAFSTSSPLAKHQRIHTGEKPYECK---------------- 238
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 239 ECGKAFTV--------YGQLTRHQSIHTGEKPFE--------CKECGKAFRLSSFLHA-------------------HQR 283
Cdd:COG5048   112 SSSSNSNDnnllsshsLPPSSRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 284 IHAGIKPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPHECKECG------KAFI 357
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 358 SRHQLTVHQRVHTG-EKPYECKECGKAFRVHVHLTQHR--KIHT--DVKPYECKE--CGKTFSRASYLVQHGRIHTGKKP 430
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 431 YECK--ECGKAFSSGSY-----LVQHQRIHTGEKPYEC--NKCGKAFTVYGQLIGHQSVHTGEKP--FECKECGKAFRLN 499
Cdd:COG5048   352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1622896448 500 SFLTEHQRVHTGEKPFKCKICGKtFRYSSALKVHLR 535
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-220 1.52e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  18 MLPSENCPSFAPHQKISRQKPRECREYGKTLCQDSKPVQH--ERIHSSEKPNRCKECGKNFSNGHQLTIHQRLYVDE--- 92
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSges 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  93 -KPYKC--EKCGKAFIRGSAFVKHRRIHTGEKSLKCK--RCEKTFSG-----NYQLTVHESIHTGKKPYEC--GECGKAF 160
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622896448 161 LAYGKLTRHQSIHTGEKPFVCE--ECGKAFSTFSYLIQHQRIHTGEKPYECKECGKAFSTSS 220
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-535 7.52e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 7.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 177 KPFVCEECGKAFSTFSYLIQHQRIHTGEKPYEC--KECGKAFSTSSPLAKHQRIHTGEKPYECK---------------- 238
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 239 ECGKAFTV--------YGQLTRHQSIHTGEKPFE--------CKECGKAFRLSSFLHA-------------------HQR 283
Cdd:COG5048   112 SSSSNSNDnnllsshsLPPSSRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 284 IHAGIKPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPHECKECG------KAFI 357
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 358 SRHQLTVHQRVHTG-EKPYECKECGKAFRVHVHLTQHR--KIHT--DVKPYECKE--CGKTFSRASYLVQHGRIHTGKKP 430
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 431 YECK--ECGKAFSSGSY-----LVQHQRIHTGEKPYEC--NKCGKAFTVYGQLIGHQSVHTGEKP--FECKECGKAFRLN 499
Cdd:COG5048   352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1622896448 500 SFLTEHQRVHTGEKPFKCKICGKtFRYSSALKVHLR 535
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-220 1.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  18 MLPSENCPSFAPHQKISRQKPRECREYGKTLCQDSKPVQH--ERIHSSEKPNRCKECGKNFSNGHQLTIHQRLYVDE--- 92
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSges 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  93 -KPYKC--EKCGKAFIRGSAFVKHRRIHTGEKSLKCK--RCEKTFSG-----NYQLTVHESIHTGKKPYEC--GECGKAF 160
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622896448 161 LAYGKLTRHQSIHTGEKPFVCE--ECGKAFSTFSYLIQHQRIHTGEKPYECKECGKAFSTSS 220
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-218 5.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622896448 193 YLIQHQRIHTGEKPYECKECGKAFST 218
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 177-229 6.00e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 6.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622896448 177 KPFvCEECGKAFSTFSYLIQHQRIHTgekpYECKECGKAFSTSSPLAKH-QRIH 229
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
177-535 7.52e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.04  E-value: 7.52e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 177 KPFVCEECGKAFSTFSYLIQHQRIHTGEKPYEC--KECGKAFSTSSPLAKHQRIHTGEKPYECK---------------- 238
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 239 ECGKAFTV--------YGQLTRHQSIHTGEKPFE--------CKECGKAFRLSSFLHA-------------------HQR 283
Cdd:COG5048   112 SSSSNSNDnnllsshsLPPSSRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLHPplpanslskdpssnlslliSSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 284 IHAGIKPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKECGKAFSTGSYLVQHQRIHTGEKPHECKECG------KAFI 357
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 358 SRHQLTVHQRVHTG-EKPYECKECGKAFRVHVHLTQHR--KIHT--DVKPYECKE--CGKTFSRASYLVQHGRIHTGKKP 430
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 431 YECK--ECGKAFSSGSY-----LVQHQRIHTGEKPYEC--NKCGKAFTVYGQLIGHQSVHTGEKP--FECKECGKAFRLN 499
Cdd:COG5048   352 AKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1622896448 500 SFLTEHQRVHTGEKPFKCKICGKtFRYSSALKVHLR 535
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-537 5.45e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 5.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 205 KPYECKECGKAFSTSSPLAKHQRIHTGEKPYEC--KECGKAFTVYGQLTRHQSIHTGEKPFECKecgKAFRLSSFLHAHQ 282
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 283 RIHAGI----KPYGCKECGKTFSRASYLVQHGRLHTGEKPYECKEC-----------------------GKAFSTGSYLV 335
Cdd:COG5048   109 SLSSSSsnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslsKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 336 QHQRIHTGEKPHECKECGKAFISRHQLTVHQRVH-----------------------TGEKPY----ECKECGKAFRVHV 388
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsssslplttnsqlspksllsqspSSLSSSdsssSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 389 HLTQHRKIHTDV-------KPYECKECGKTFSRASYLVQH--GRIHTGK--KPYECKE--CGKAFSSGSYLVQHQRIHTG 455
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 456 EKPYEC--NKCGKAFTV-----YGQLIGHQSVHTGEKPFEC--KECGKAFRLNSFLTEHQRVHTGEKP--FKCKICGKTF 524
Cdd:COG5048   349 ISPAKEklLNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410
                  ....*....|...
gi 1622896448 525 RYSSALKVHLRKH 537
Cdd:COG5048   429 NRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
18-220 1.52e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.85  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  18 MLPSENCPSFAPHQKISRQKPRECREYGKTLCQDSKPVQH--ERIHSSEKPNRCKECGKNFSNGHQLTIHQRLYVDE--- 92
Cdd:COG5048   239 SLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESdsSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSges 318

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  93 -KPYKC--EKCGKAFIRGSAFVKHRRIHTGEKSLKCK--RCEKTFSG-----NYQLTVHESIHTGKKPYEC--GECGKAF 160
Cdd:COG5048   319 lKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNF 398

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622896448 161 LAYGKLTRHQSIHTGEKPFVCE--ECGKAFSTFSYLIQHQRIHTGEKPYECKECGKAFSTSS 220
Cdd:COG5048   399 KRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
289-542 1.01e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 1.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 289 KPYGCKECGKTFSRASYLVQHGRLHTGEKPYEC--KECGKAFSTGSYLVQHQRIHTGEKPHECKecgKAFISRHQLTVHQ 366
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 367 --RVHTGEKPYECKECGKAFRVHVHLTQHRKIHTDVKPYECKE-------------------------CGKTFSRASYLV 419
Cdd:COG5048   109 slSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 420 QHGRIHTGKKPYECKEC---GKAFSSGSYLV---------QHQRIHTGEKPY---------------ECNKCGKAFTVYG 472
Cdd:COG5048   189 SSNVSTSIPSSSENSPLsssYSIPSSSSDQNlensssslpLTTNSQLSPKSLlsqspsslsssdsssSASESPRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 473 QLIGHQSVHTGE-------KPFECKECGKAFRLNSFLTEHQR--VHTGE--KPFKC--KICGKTFRYSSALKVHLRKHMG 539
Cdd:COG5048   269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348


                  ...
gi 1622896448 540 VIP 542
Cdd:COG5048   349 ISP 351
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 455-537 1.15e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.79  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 455 GEKPYECN--KCGKAFT-----VYGQLIGHQSVHTGEKPFECKecgkafrLNSFLTEhqrvhtgEKPFKCKICGKTFRYS 527
Cdd:COG5189   346 DGKPYKCPveGCNKKYKnqnglKYHMLHGHQNQKLHENPSPEK-------MNIFSAK-------DKPYRCEVCDKRYKNL 411

                          90
                  ....*....|
gi 1622896448 528 SALKVHlRKH 537
Cdd:COG5189   412 NGLKYH-RKH 420
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
399-466 2.76e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.76e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448 399 DVKPYECKECGKTFSRASYLVQHGRIHTGKKPYEC--KECGKAFSSGSYLVQHQRIHTGEKPYECNKCGK 466
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP 99
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-218 5.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.81e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622896448 193 YLIQHQRIHTGEKPYECKECGKAFST 218
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 177-229 6.00e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 38.69  E-value: 6.00e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622896448 177 KPFvCEECGKAFSTFSYLIQHQRIHTgekpYECKECGKAFSTSSPLAKH-QRIH 229
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
333-358 8.03e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.03e-04
                          10        20
                  ....*....|....*....|....*.
gi 1622896448 333 YLVQHQRIHTGEKPHECKECGKAFIS 358
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
222-245 1.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.07e-03
                          10        20
                  ....*....|....*....|....
gi 1622896448 222 LAKHQRIHTGEKPYECKECGKAFT 245
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 51-202 1.45e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622896448  51 DSKPVQHERIHSSEKPNRCKECGKNFSNGHQLTIH---QRLYV-DEKPYKCEKCGkafirgsafvkhrrihtgekslkck 126
Cdd:COG5189   302 RGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPVEG------------------------- 356

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622896448 127 rCEKTFSGNYQLTVHEsIHtgkkpyecGECGKAFLAYGKLTRHQSIHTGEKPFVCEECGKAFSTFSYLIQHqRIHT 202
Cdd:COG5189   357 -CNKKYKNQNGLKYHM-LH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
445-469 1.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.51e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896448 445 YLVQHQRIHTGEKPYECNKCGKAFT 469
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 485-534 2.85e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 2.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622896448 485 KPFeCKECGKAFRLNSFLTEHQRvhtgEKPFKCKICGKTFRYSSALKVHL 534
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
502-526 4.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.52e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896448 502 LTEHQRVHTGEKPFKCKICGKTFRY 526
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 515-537 5.76e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.76e-03
                          10        20
                  ....*....|....*....|...
gi 1622896448 515 FKCKICGKTFRYSSALKVHLRKH 537
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
362-384 6.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.64e-03
                          10        20
                  ....*....|....*....|...
gi 1622896448 362 LTVHQRVHTGEKPYECKECGKAF 384
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
250-272 7.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.11e-03
                          10        20
                  ....*....|....*....|...
gi 1622896448 250 LTRHQSIHTGEKPFECKECGKAF 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-190 7.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.18e-03
                          10        20
                  ....*....|....*....|....*
gi 1622896448 166 LTRHQSIHTGEKPFVCEECGKAFST 190
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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