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Conserved domains on  [gi|1622894576|ref|XP_028694840|]
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bile salt sulfotransferase isoform X2 [Macaca mulatta]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-249 2.93e-88

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 261.89  E-value: 2.93e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  34 DEDVIILTYPKSGTNWLIEILCLIHSNGDPKWIQSVPI---WERSPWVE---------TEMGYKLLSEEEGPRLFSSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 102 IQLFPKSFFSSKAKVIYLMRNPRDVFVSGYFFWNSVKFVKKPKSWEQYFEWFCQGNVIYGSWFDHIHGWMPMREKKNFLL 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622894576 182 LSYEELKQDTRRTVEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNFSLLSvdfvEDKAQLLRKG 249
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP----KEVSPFFRKG 224
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-249 2.93e-88

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 261.89  E-value: 2.93e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  34 DEDVIILTYPKSGTNWLIEILCLIHSNGDPKWIQSVPI---WERSPWVE---------TEMGYKLLSEEEGPRLFSSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 102 IQLFPKSFFSSKAKVIYLMRNPRDVFVSGYFFWNSVKFVKKPKSWEQYFEWFCQGNVIYGSWFDHIHGWMPMREKKNFLL 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622894576 182 LSYEELKQDTRRTVEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNFSLLSvdfvEDKAQLLRKG 249
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP----KEVSPFFRKG 224
PLN02164 PLN02164
sulfotransferase
 21-224 1.03e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 97.68  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  21 ETLRKVRDEFVIKDEDVIILTYPKSGTNWLiEILCLIHSNGDPKWIQSVPIWERSP-----WVETEMGYKL---LSEEEG 92
Cdd:PLN02164   66 EGLLHAQEFFQARPNDFLVCSYPKTGTTWL-KALTFAIANRSRFDDSSNPLLKRNPhefvpYIEIDFPFFPsvdVLKDKG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  93 PRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVFVSGYFFWNSVKFVKKP-KSWEQYFEWFCQGNVIYGSWFDHIHG-W 170
Cdd:PLN02164  145 NTLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGyW 224

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 171 MPMREKKN-FLLLSYEELKQDTRRTVEKICQFLGK--TLEPEELNL---ILKNSSFQSMK 224
Cdd:PLN02164  225 KAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYgfTAEEEEKGVvekVVKLCSFETLK 284
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-231 3.41e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.85  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  38 IILTYPKSGTNWLIEIL-------C---LIHSNGDPKWIQSVPIWER----SPWVETEM----------GYKLlSEEEGP 93
Cdd:COG4424    10 VICATPRSGSTLLCELLnatgvagCpgeYFNPPFIPEWARGFLLGDRdrdpDEYLRAIRragttpngvfGFKL-FWDQLP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  94 RLFSSHLPI-QLFPKsffsskAKVIYLMR-NPRDVFVSgyffwnsvkFVK--KPKSW---------------------EQ 148
Cdd:COG4424    89 RLLQRALRLlAAFPD------LKFIHLTRrDKLAQAVS---------LVIaqQTGQWhsdaddalaptappeydaeeiAR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 149 YFEWFCQGNVIYGSWFDhIHGWMPMRekknfllLSYEELKQDTRRTVEKICQFLGKTLEPEELNLIL-KNSSFQSmkENK 227
Cdd:COG4424   154 LLEALQDFEARWEAWFA-RTGITPLE-------ITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALkKQADEPS--DEW 223


                  ....
gi 1622894576 228 MSNF 231
Cdd:COG4424   224 VARF 227
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
34-249 2.93e-88

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 261.89  E-value: 2.93e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  34 DEDVIILTYPKSGTNWLIEILCLIHSNGDPKWIQSVPI---WERSPWVE---------TEMGYKLLSEEEGPRLFSSHLP 101
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEwypgdtyfdVAEGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 102 IQLFPKSFFSSKAKVIYLMRNPRDVFVSGYFFWNSVKFVKKPKSWEQYFEWFCQGNVIYGSWFDHIHGWMPMREKKNFLL 181
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622894576 182 LSYEELKQDTRRTVEKICQFLGKTLEPEELNLILKNSSFQSMKENKMSNFSLLSvdfvEDKAQLLRKG 249
Cdd:pfam00685 161 LRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP----KEVSPFFRKG 224
PLN02164 PLN02164
sulfotransferase
 21-224 1.03e-23

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 97.68  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  21 ETLRKVRDEFVIKDEDVIILTYPKSGTNWLiEILCLIHSNGDPKWIQSVPIWERSP-----WVETEMGYKL---LSEEEG 92
Cdd:PLN02164   66 EGLLHAQEFFQARPNDFLVCSYPKTGTTWL-KALTFAIANRSRFDDSSNPLLKRNPhefvpYIEIDFPFFPsvdVLKDKG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  93 PRLFSSHLPIQLFPKSFFSSKAKVIYLMRNPRDVFVSGYFFWNSVKFVKKP-KSWEQYFEWFCQGNVIYGSWFDHIHG-W 170
Cdd:PLN02164  145 NTLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDHVLGyW 224

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 171 MPMREKKN-FLLLSYEELKQDTRRTVEKICQFLGK--TLEPEELNL---ILKNSSFQSMK 224
Cdd:PLN02164  225 KAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYgfTAEEEEKGVvekVVKLCSFETLK 284
Sulfotransfer_3 pfam13469
Sulfotransferase family;
37-208 4.79e-13

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 65.39  E-value: 4.79e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  37 VIILTYPKSGTNWLIEILCLiHS--NGDPKWIQSVPIW--ERSPWVETemGYKLLSEEEGPRLFSSHLP---------IQ 103
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAA-HPdvRPPEETWFVIPRIlaLLQAWGKS--LEALARVPSYARWLCDKSPshlfhldllLK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 104 LFPKsffsskAKVIYLMRNPRDVFVSGYFFWnsvkFVKKPKSWEQYFEWFCQGNVIYgsWFDHIHGWMPMREK---KNFL 180
Cdd:pfam13469  78 AFPD------AKFIHLHRDPVDTVISSYCSL----FGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARARvppGRFL 145

                         170       180
                  ....*....|....*....|....*...
gi 1622894576 181 LLSYEELKQDTRRTVEKICQFLGKTLEP 208
Cdd:pfam13469 146 DVRYEDLVADPEGTLRRILEFLGLPWDD 173
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
38-231 3.41e-05

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 43.85  E-value: 3.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  38 IILTYPKSGTNWLIEIL-------C---LIHSNGDPKWIQSVPIWER----SPWVETEM----------GYKLlSEEEGP 93
Cdd:COG4424    10 VICATPRSGSTLLCELLnatgvagCpgeYFNPPFIPEWARGFLLGDRdrdpDEYLRAIRragttpngvfGFKL-FWDQLP 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576  94 RLFSSHLPI-QLFPKsffsskAKVIYLMR-NPRDVFVSgyffwnsvkFVK--KPKSW---------------------EQ 148
Cdd:COG4424    89 RLLQRALRLlAAFPD------LKFIHLTRrDKLAQAVS---------LVIaqQTGQWhsdaddalaptappeydaeeiAR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622894576 149 YFEWFCQGNVIYGSWFDhIHGWMPMRekknfllLSYEELKQDTRRTVEKICQFLGKTLEPEELNLIL-KNSSFQSmkENK 227
Cdd:COG4424   154 LLEALQDFEARWEAWFA-RTGITPLE-------ITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALkKQADEPS--DEW 223


                  ....
gi 1622894576 228 MSNF 231
Cdd:COG4424   224 VARF 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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