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Conserved domains on  [gi|1622824923|ref|XP_028694319|]
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inactive polyglycylase TTLL10 isoform X4 [Macaca mulatta]

Protein Classification

ATP-grasp domain-containing protein( domain architecture ID 106900)

ATP-grasp domain-containing protein may be related to carbamoyl phosphate synthetase and predicted to be involved in the biosynthesis of a ribonucleoside involved in stress response

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CPSase_L_D2 super family cl17255
Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase ...
 255-510 3.31e-45

Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.


The actual alignment was detected with superfamily member pfam03133:

Pssm-ID: 473076  Cd Length: 291  Bit Score: 162.89  E-value: 3.31e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 255 EEFFPETYRLDLkhEREAFFTLF--DETQIWICKPTASNQGKGIFLlrkqeevaalqakTRSAEDDPIHHKSpfrgpQAR 332
Cdd:pfam03133  41 GDFLPRTFILPT--DLAEFVDYFedRERNTWIVKPSASARGRGIRV-------------TNKLSQIPKWSQS-----RPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 333 VVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIF-FSHGYARLTLSLYDPHSSDLSG---HLTNQFMQKKSPL---YVLL 405
Cdd:pfam03133 101 VVQKYIERPLLIDGRKFDIRLYVLVTSVNPLRVYvYREGLLRFASVKYSPSSSDLDDvemHLTNYSIQKKSSSlneDYNE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 406 KEDTVWSMERLNRYInttfwkaRGLPKDWVFTTLTK-RMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLE 484
Cdd:pfam03133 181 PHGHKWSLQNFWKYL-------EEKDKDEIWLEIESiIIKTILAAEVEASRLNVQPLPNCFELYGFDFMIDENLKPWLLE 253

                         250       260
                  ....*....|....*....|....*.
gi 1622824923 485 MNSNPALHTNCEVLKEVIPGVVIETL 510
Cdd:pfam03133 254 VNSSPSLHSTTKLDARLKEQLIDDVL 279
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 560-665 1.08e-06

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSP---GTA 636
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPapaPAA 472

                          90       100
                  ....*....|....*....|....*....
gi 1622824923 637 KEERKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  473 APEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
 
Name Accession Description Interval E-value
TTL pfam03133
Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several ...
 255-510 3.31e-45

Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyzes the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.


Pssm-ID: 397308  Cd Length: 291  Bit Score: 162.89  E-value: 3.31e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 255 EEFFPETYRLDLkhEREAFFTLF--DETQIWICKPTASNQGKGIFLlrkqeevaalqakTRSAEDDPIHHKSpfrgpQAR 332
Cdd:pfam03133  41 GDFLPRTFILPT--DLAEFVDYFedRERNTWIVKPSASARGRGIRV-------------TNKLSQIPKWSQS-----RPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 333 VVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIF-FSHGYARLTLSLYDPHSSDLSG---HLTNQFMQKKSPL---YVLL 405
Cdd:pfam03133 101 VVQKYIERPLLIDGRKFDIRLYVLVTSVNPLRVYvYREGLLRFASVKYSPSSSDLDDvemHLTNYSIQKKSSSlneDYNE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 406 KEDTVWSMERLNRYInttfwkaRGLPKDWVFTTLTK-RMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLE 484
Cdd:pfam03133 181 PHGHKWSLQNFWKYL-------EEKDKDEIWLEIESiIIKTILAAEVEASRLNVQPLPNCFELYGFDFMIDENLKPWLLE 253

                         250       260
                  ....*....|....*....|....*.
gi 1622824923 485 MNSNPALHTNCEVLKEVIPGVVIETL 510
Cdd:pfam03133 254 VNSSPSLHSTTKLDARLKEQLIDDVL 279
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-665 1.08e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSP---GTA 636
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPapaPAA 472

                          90       100
                  ....*....|....*....|....*....
gi 1622824923 637 KEERKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  473 APEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-660 1.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 561 PPTRQAKSSGPPTPRAPDQPGTR--RPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKE 638
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQaaTAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQ 250

                          90       100
                  ....*....|....*....|....
gi 1622824923 639 ERKE--PENARPWGGHPRPTPHAP 660
Cdd:pfam03154 251 PMTQppPPSQVSPQPLPQPSLHGQ 274
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 560-668 1.10e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 41.68  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPV--PPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 637
Cdd:NF040712  226 APATDSDPAEAGTPDDLASARRRRAGVeqPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAP 305

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622824923 638 EERKEPENARPwGGHPRPTPHAP---ATLPAFRD 668
Cdd:NF040712  306 AAPEAEEPARP-EPPPAPKPKRRrrrASVPSWDD 338
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 563-664 3.88e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.52  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 563 TRQAKSSGPPTPRAPDQPGTRRPVP-------PPLAPQRPQLPGPSPDPDSahdgQPQAPGKEQSGTGDR-HPEQEPSPG 634
Cdd:NF033839  273 TKFKKGLTQDTPKEPGNKKPSAPKPgmqpspqPEKKEVKPEPETPKPEVKP----QLEKPKPEVKPQPEKpKPEVKPQLE 348

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824923 635 TAKEE-RKEPENARPwGGHPRPTPHAPATLP 664
Cdd:NF033839  349 TPKPEvKPQPEKPKP-EVKPQPEKPKPEVKP 378
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 556-666 4.02e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.14  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 556 RRRLPPPTRQAkssgpPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGT 635
Cdd:NF040712  196 LRPLATVPRLA-----REPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824923 636 AKEERKEPENARPWGGHPRPTPHAPATLPAF 666
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAAEPPAPAPAA 301
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 572-662 6.66e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 572 PTPRAPDQPGTRRP-VPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKE---QSGTGDrhPEQEPSPGTAKEERK-EPENA 646
Cdd:NF033839  405 PKPEVKPQPEKPKPeVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkpQPETPK--PEVKPQPEKPKPEVKpQPEKP 482

                          90
                  ....*....|....*.
gi 1622824923 647 RPWGGHPRPTPHAPAT 662
Cdd:NF033839  483 KPDNSKPQADDKKPST 498
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 560-629 7.07e-03

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 39.12  E-value: 7.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSahdgqpQAPGKEQSGTGDRHPEQ 629
Cdd:NF040983   96 PPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPT------RTTPSTTTPTPSMHPIQ 159
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 572-664 7.91e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.37  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 572 PTPRAPDQPGTRRPV--PPPLAPQ---RPQLPGPSPD-------PDSAHDGQPQAPgkeqsgtgdrHPEQEPSPGTAKEE 639
Cdd:NF033839  339 PKPEVKPQLETPKPEvkPQPEKPKpevKPQPEKPKPEvkpqpetPKPEVKPQPEKP----------KPEVKPQPEKPKPE 408

                          90       100
                  ....*....|....*....|....*.
gi 1622824923 640 RK-EPENARPwGGHPRPTPHAPATLP 664
Cdd:NF033839  409 VKpQPEKPKP-EVKPQPEKPKPEVKP 433
 
Name Accession Description Interval E-value
TTL pfam03133
Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several ...
 255-510 3.31e-45

Tubulin-tyrosine ligase family; Tubulins and microtubules are subjected to several post-translational modifications of which the reversible detyrosination/tyrosination of the carboxy-terminal end of most alpha-tubulins has been extensively analysed. This modification cycle involves a specific carboxypeptidase and the activity of the tubulin-tyrosine ligase (TTL). The true physiological function of TTL has so far not been established. Tubulin-tyrosine ligase (TTL) catalyzes the ATP-dependent post-translational addition of a tyrosine to the carboxy terminal end of detyrosinated alpha-tubulin. In normally cycling cells, the tyrosinated form of tubulin predominates. However, in breast cancer cells, the detyrosinated form frequently predominates, with a correlation to tumour aggressiveness. On the other hand, 3-nitrotyrosine has been shown to be incorporated, by TTL, into the carboxy terminal end of detyrosinated alpha-tubulin. This reaction is not reversible by the carboxypeptidase enzyme. Cells cultured in 3-nitrotyrosine rich medium showed evidence of altered microtubule structure and function, including altered cell morphology, epithelial barrier dysfunction, and apoptosis. Bacterial homologs of TTL are predicted to form peptide tags. Some of these are fused to a 2-oxoglutarate Fe(II)-dependent dioxygenase domain.


Pssm-ID: 397308  Cd Length: 291  Bit Score: 162.89  E-value: 3.31e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 255 EEFFPETYRLDLkhEREAFFTLF--DETQIWICKPTASNQGKGIFLlrkqeevaalqakTRSAEDDPIHHKSpfrgpQAR 332
Cdd:pfam03133  41 GDFLPRTFILPT--DLAEFVDYFedRERNTWIVKPSASARGRGIRV-------------TNKLSQIPKWSQS-----RPL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 333 VVQRYIQNPLLLDGRKFDVRSYLLIACTTPYMIF-FSHGYARLTLSLYDPHSSDLSG---HLTNQFMQKKSPL---YVLL 405
Cdd:pfam03133 101 VVQKYIERPLLIDGRKFDIRLYVLVTSVNPLRVYvYREGLLRFASVKYSPSSSDLDDvemHLTNYSIQKKSSSlneDYNE 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 406 KEDTVWSMERLNRYInttfwkaRGLPKDWVFTTLTK-RMQQIMAHCFLAAKSKLECKLGYFDLIGCDFLIDDNFKVWLLE 484
Cdd:pfam03133 181 PHGHKWSLQNFWKYL-------EEKDKDEIWLEIESiIIKTILAAEVEASRLNVQPLPNCFELYGFDFMIDENLKPWLLE 253

                         250       260
                  ....*....|....*....|....*.
gi 1622824923 485 MNSNPALHTNCEVLKEVIPGVVIETL 510
Cdd:pfam03133 254 VNSSPSLHSTTKLDARLKEQLIDDVL 279
ATPgrasp_YheCD pfam14398
YheC/D like ATP-grasp; A member of the ATP-grasp fold predicted to be involved in the ...
 237-489 3.92e-07

YheC/D like ATP-grasp; A member of the ATP-grasp fold predicted to be involved in the modification/biosynthesis of spore-wall and capsular proteins.


Pssm-ID: 405146 [Multi-domain]  Cd Length: 256  Bit Score: 51.80  E-value: 3.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 237 DLPWTSPG---------HLRPQRVLRmeEFFPETYRLDlkhEREAFFTLFDETQIWICKPTASNQGKGIFLLRKQEEVAA 307
Cdd:pfam14398   1 GIPFFNPGffnkwevyeLLSKDPELR--PYLPETELLQ---SPEDLERMLEKYGSVYLKPVNGSLGKGILRIEKDGGGYY 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 308 LQAKTR--------SAEDDPIHHKSPFRGPQARVVQRYIqNPLLLDGRKFDVRsyLLI--------ACTTpymiffshGY 371
Cdd:pfam14398  76 LYGRYGknsktnrfLDFSELESFLRRLLGKKRYIIQQGI-DLATIDGRPFDFR--VLVqkngkgkwVVTG--------IA 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 372 ARLTlslyDPHS--SDLSGHLTnqfmqkksplyvllkedtvwsMERLNRYINTTFWKARGLPkdwvfttLTKRMQQImah 449
Cdd:pfam14398 145 ARIA----GPGSitTNLSGGGT---------------------AIPLEEALRRAFGEERAEK-------ILEKLEEL--- 189

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1622824923 450 CFLAAKSkLECKLGYFDLIGCDFLIDDNFKVWLLEMNSNP 489
Cdd:pfam14398 190 ALELARA-LEESFGGLGELGLDLGIDKNGRVWLLEVNSKP 228
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-665 1.08e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 51.91  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSP---GTA 636
Cdd:PRK07764  394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQ-PAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPapaPAA 472

                          90       100
                  ....*....|....*....|....*....
gi 1622824923 637 KEERKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  473 APEPTAAPAPAPPAAPAPAAAPAAPAAPA 501
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-667 3.35e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 3.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  557 RRL--PPPTRQAKS--------SGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGkEQSGTGDRH 626
Cdd:PHA03247  2884 RRLarPAVSRSTESfalppdqpERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAG-EPSGAVPQP 2962

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1622824923  627 PEQEPSPGTAKEERKEPENARPWGGHPRPTPHAPATLPAFR 667
Cdd:PHA03247  2963 WLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSR 3003
PHA03247 PHA03247
large tegument protein UL36; Provisional
 555-655 1.18e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 1.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  555 LRRRLP---PPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQ-- 629
Cdd:PHA03247  2862 VRRRPPsrsPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPE-RPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRpq 2940

                           90       100
                   ....*....|....*....|....*....
gi 1622824923  630 ---EPSPGTAKEERKEPENARPWGGHPRP 655
Cdd:PHA03247  2941 pplAPTTDPAGAGEPSGAVPQPWLGALVP 2969
PHA03378 PHA03378
EBNA-3B; Provisional
 556-662 1.41e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 48.52  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 556 RRRLPP--PTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGD-RHPEQEPS 632
Cdd:PHA03378  693 TMQPPPraPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRaRPPAAAPG 772

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1622824923 633 PGTAKEERKEPENA--RPWGG-HPRPTPHAPAT 662
Cdd:PHA03378  773 APTPQPPPQAPPAPqqRPRGApTPQPPPQAGPT 805
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-665 1.61e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 1.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  557 RRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAP----QRPQLPGPSPD--PDSAHDGQPQAPGKEQSGTGDRHPEQE 630
Cdd:PHA03247  2659 GRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSltslADPPPPPPTPEpaPHALVSATPLPPGPAAARQASPALPAA 2738

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1622824923  631 PSPGTAKEerkepENARPWGGHPRPTPHAPATLPA 665
Cdd:PHA03247  2739 PAPPAVPA-----GPATPGGPARPARPPTTAGPPA 2768
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 562-668 2.66e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 47.38  E-value: 2.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 562 PTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPgPSPDPDSAHDgQPQAPGKEQSGTGDRHP--EQEPSPGTAKEE 639
Cdd:PTZ00449  573 PTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRP-KSPKLPELLD-IPKSPKRPESPKSPKRPppPQRPSSPERPEG 650

                          90       100
                  ....*....|....*....|....*....
gi 1622824923 640 RKEPENARPwgghprPTPHAPATLPAFRD 668
Cdd:PTZ00449  651 PKIIKSPKP------PKSPKPPFDPKFKE 673
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-669 3.83e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 3.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  557 RRLPPP------------TRQAKSSGPP---TPRAP-----DQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPG 616
Cdd:PHA03247  2566 RSVPPPrpaprpsepavtSRARRPDAPPqsaRPRAPvddrgDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622824923  617 KEQSgtgdRHPEQEPSPGTAKEERKEPENARPWGGH-----PRPtPHAPATLPAFRDL 669
Cdd:PHA03247  2646 VPPP----ERPRDDPAPGRVSRPRRARRLGRAAQASsppqrPRR-RAARPTVGSLTSL 2698
PHA03378 PHA03378
EBNA-3B; Provisional
 547-664 5.58e-05

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 46.60  E-value: 5.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 547 PRLGGSCSLRRRLPPPTRQAKSSGPPTPRAPdqpgtrrPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPgkeqSGTGDRH 626
Cdd:PHA03378  676 PSPTGANTMLPIQWAPGTMQPPPRAPTPMRP-------PAAPPGRAQRPAAATGRARPPAAAPGRARPP----AAAPGRA 744

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1622824923 627 PEQEPSPGTAKEERKEPENARPWGGHP-RPTPHAPATLP 664
Cdd:PHA03378  745 RPPAAAPGRARPPAAAPGRARPPAAAPgAPTPQPPPQAP 783
PHA03247 PHA03247
large tegument protein UL36; Provisional
 550-667 1.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  550 GGSCSLRRRLPPPTRQAKSSGPP---TPRA--------------PDQPGTRRPVPPPLAPQRPQLPGP-----SPDPDSA 607
Cdd:PHA03247  2658 PGRVSRPRRARRLGRAAQASSPPqrpRRRAarptvgsltsladpPPPPPTPEPAPHALVSATPLPPGPaaarqASPALPA 2737

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  608 HDGQPQAPGKEQSGTGDRHPEQEPSPGTAkeERKEPENARPWGGHPRPTPHAPATLPAFR 667
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARPPTTAGP--PAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 567-665 1.39e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 45.07  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 567 KSSGPPTPRAPDQpgTRRPVPP--PLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEERKEP- 643
Cdd:PTZ00449  704 KETLPETPGTPFT--TPRPLPPklPRDEEFPFEPIGDPDAEQPDDIEFFTPPEEERTFFHETPADTPLPDILAEEFKEEd 781

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824923 644 ---ENARPWGGHPRP------TPHAPATLPA 665
Cdd:PTZ00449  782 ihaETGEPDEAMKRPdspsehEDKPPGDHPS 812
dnaA PRK14086
chromosomal replication initiator protein DnaA;
552-665 1.58e-04

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 44.82  E-value: 1.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 552 SCSLRRRLPPPTRQA----KSSGPPTPrapdqpgtrrPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHP 627
Cdd:PRK14086   71 SETLSRELGRPIRIAitvdPSAGEPAP----------PPPHARRTSEPELPRPGRRPYEGYGGPRADDRPPGLPRQDQLP 140

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622824923 628 EQEPSpGTAKEERKEP------ENARPW----GGHPRPTPHAPATLPA 665
Cdd:PRK14086  141 TARPA-YPAYQQRPEPgawpraADDYGWqqqrLGFPPRAPYASPASYA 187
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 542-661 1.61e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 542 EADVWPRLGGSCSLRRRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPlapqrpqlPGPSPDPDSAHDGQPQAPGKEQSG 621
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPP--------AGQADDPAAQPPQAAQGASAPSPA 734

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1622824923 622 TGD---RHPEQEPSPGTAKEERKE-----PENARPWGGHPRPTPHAPA 661
Cdd:PRK07764  735 ADDpvpLPPEPDDPPDPAGAPAQPppppaPAPAAAPAAAPPPSPPSEE 782
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 566-665 2.92e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 566 AKSSGPPTPRAPDQPGtrrpvpPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGdrHPEQEPSPGTAKEERKEPEN 645
Cdd:PRK07764  592 PGAAGGEGPPAPASSG------PPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAP--APGVAAPEHHPKHVAVPDAS 663

                          90       100
                  ....*....|....*....|
gi 1622824923 646 ARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPPP 683
PHA03247 PHA03247
large tegument protein UL36; Provisional
 559-665 3.19e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 3.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  559 LPPPTRQAKSSgPPTPRAPDQPG------------------TRRPVPPPLAPQRP---QLPGPSPDPDSAHDGQPQAPGK 617
Cdd:PHA03247  2828 LPPPTSAQPTA-PPPPPGPPPPSlplggsvapggdvrrrppSRSPAAKPAAPARPpvrRLARPAVSRSTESFALPPDQPE 2906

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1622824923  618 EQsgtgdRHPEQEPSPGTAKEERKEPENARPWGGHPRP-TPHAPATLPA 665
Cdd:PHA03247  2907 RP-----PQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPqPPLAPTTDPA 2950
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 561-668 3.20e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 43.93  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 561 PPTRQAKSSGPPTPRAPDQPGTRRP---VPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 637
Cdd:PRK14951  383 RPEAAAPAAAPVAQAAAAPAPAAAPaaaASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAI 462

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824923 638 EERKEPENARPWGGHPRPTPHAPATLPAFRD 668
Cdd:PRK14951  463 PVRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PHA03269 PHA03269
envelope glycoprotein C; Provisional
 572-667 3.87e-04

envelope glycoprotein C; Provisional


Pssm-ID: 165527 [Multi-domain]  Cd Length: 566  Bit Score: 43.56  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 572 PTPRAPDQPGTRRPVPPPLAPQRP-QLPGPSPDPDSAHDGQPQaPGKEQSGTGDRHPEQEPSPGTAKEERKEPENARPWG 650
Cdd:PHA03269   27 PIPELHTSAATQKPDPAPAPHQAAsRAPDPAVAPTSAASRKPD-LAQAPTPAASEKFDPAPAPHQAASRAPDPAVAPQLA 105

                          90
                  ....*....|....*..
gi 1622824923 651 GHPRPTPHAPATLPAFR 667
Cdd:PHA03269  106 AAPKPDAAEAFTSAAQA 122
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-665 3.94e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 3.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPqlPGPSPDPDSahdGQPQAPGKEQSGTGDRHPEQEPSPGTAKEE 639
Cdd:PRK07764  406 PAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAP--PSPAGNAPA---GGAPSPPPAAAPSAQPAPAPAAAPEPTAAP 480

                          90       100
                  ....*....|....*....|....*.
gi 1622824923 640 RKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  481 APAPPAAPAPAAAPAAPAAPAAPAGA 506
PHA03247 PHA03247
large tegument protein UL36; Provisional
 571-668 6.68e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 6.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  571 PPTPRAPDQPGTRRPVPPPLAPQRPqlPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEERKEPENARPWG 650
Cdd:PHA03247  2553 PPLPPAAPPAAPDRSVPPPRPAPRP--SEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS 2630

                           90       100
                   ....*....|....*....|..
gi 1622824923  651 GHPRPT----PHAPATLPAFRD 668
Cdd:PHA03247  2631 PSPAANepdpHPPPTVPPPERP 2652
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 561-660 1.01e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 561 PPTRQAKSSGPPTPRAPDQPGTR--RPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKE 638
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQaaTAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQ 250

                          90       100
                  ....*....|....*....|....
gi 1622824923 639 ERKE--PENARPWGGHPRPTPHAP 660
Cdd:pfam03154 251 PMTQppPPSQVSPQPLPQPSLHGQ 274
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 560-652 1.06e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 1.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAP---DQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQpQAPGKEQSGTGDRHPEQEPSPGTA 636
Cdd:PRK14951  406 APAAAASAPAAPPAAAPPapvAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETV-AIPVRVAPEPAVASAAPAPAAAPA 484

                          90
                  ....*....|....*.
gi 1622824923 637 KEERKEPENARPWGGH 652
Cdd:PRK14951  485 AARLTPTEEGDVWHAT 500
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 560-668 1.10e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 41.68  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPV--PPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 637
Cdd:NF040712  226 APATDSDPAEAGTPDDLASARRRRAGVeqPEDEPVGPGAAPAAEPDEATRDAGEPPAPGAAETPEAAEPPAPAPAAPAAP 305

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622824923 638 EERKEPENARPwGGHPRPTPHAP---ATLPAFRD 668
Cdd:NF040712  306 AAPEAEEPARP-EPPPAPKPKRRrrrASVPSWDD 338
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 503-637 1.12e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 42.24  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 503 PGVVIETLDLALETfQKSLRGQKMLPL---LSQRRFVLLHNGEADVWPRLGGSCSLRRRLPPPTRQAKSSGPPtPRAPDQ 579
Cdd:PRK14954  336 PAAVMQMTDFLMKT-QGELKFQFEYQFrfeLALLRLIELVRNDGGVAPSPAGSPDVKKKAPEPDLPQPDRHPG-PAKPEA 413

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622824923 580 PGtRRPVPpplapqrpqlpGPSPDPDSAHDGQPQAPgkeQSGTGDRHPEQEPSPGTAK 637
Cdd:PRK14954  414 PG-ARPAE-----------LPSPASAPTPEQQPPVA---RSAPLPPSPQASAPRNVAS 456
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 550-665 1.19e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 550 GGSCSLRRRLPPPTRQAKSSGPPTPRAPDQPGTRR-PVPPPLAPQRPQLPGPSPDPDSAHDGQPQA--PGKEQSGTGDRH 626
Cdd:PRK07764  638 EASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKaGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPapAATPPAGQADDP 717

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622824923 627 PEQEPSPGTAKEERK-----------EPENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  718 AAQPPQAAQGASAPSpaaddpvplppEPDDPPDPAGAPAQPPPPPAPAPA 767
PHA03264 PHA03264
envelope glycoprotein D; Provisional
 539-661 1.27e-03

envelope glycoprotein D; Provisional


Pssm-ID: 223029 [Multi-domain]  Cd Length: 416  Bit Score: 41.53  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 539 HNGEADVWPRLGGscslrRRLPPPTRQAKSSGPPTprAPDQpGTRRPVPPPLAPQRPQlPGPSPDPDSAHDGQPQAPGKE 618
Cdd:PHA03264  239 HKAIVDYWFMRHG-----GVVPPYFEESKGYEPPP--APSG-GSPAPPGDDRPEAKPE-PGPVEDGAPGRETGGEGEGPE 309

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622824923 619 QSGTgDRHPEQEPSPGTAkeeRKEPENARPWG-------GHPRPTPHAPA 661
Cdd:PHA03264  310 PAGR-DGAAGGEPKPGPP---RPAPDADRPEGwpsleaiTFPPPTPATPA 355
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
561-665 1.96e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 561 PPTRQAKSSGPPTPRAPdqpgTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQP-QAPGKEQSGTGDRHPEQEPSPGTAKEE 639
Cdd:PRK12323  434 AAARQASARGPGGAPAP----APAPAAAPAAAARPAAAGPRPVAAAAAAAPArAAPAAAPAPADDDPPPWEELPPEFASP 509

                          90       100
                  ....*....|....*....|....*.
gi 1622824923 640 RKEPENARPWGGHPRPTPHaPATLPA 665
Cdd:PRK12323  510 APAQPDAAPAGWVAESIPD-PATADP 534
PHA03247 PHA03247
large tegument protein UL36; Provisional
 547-666 2.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  547 PRLGGSCSLRRRLPP----PTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGT 622
Cdd:PHA03247  2720 PLPPGPAAARQASPAlpaaPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1622824923  623 GDRHPEQEPSPGTAKEErKEPENARPWGGHPRPT---PHAPATLPAF 666
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAA-ALPPAASPAGPLPPPTsaqPTAPPPPPGP 2845
PHA03247 PHA03247
large tegument protein UL36; Provisional
 558-665 2.13e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 2.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  558 RLPPPTRQAKSSGPPTPRAPDQPGTRRPvPPPLAPQRPQLP-GPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTA 636
Cdd:PHA03247  2706 PTPEPAPHALVSATPLPPGPAAARQASP-ALPAAPAPPAVPaGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT 2784

                           90       100
                   ....*....|....*....|....*....
gi 1622824923  637 KEERKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLA 2813
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 555-648 2.29e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 41.21  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 555 LRRRLPPPTRQAKSSGPPTPRAPDQPGT-RRPVPPPlAPQRPQ---LPGPSPDPDSAHdgQPQAPGKEQSGTGDRHPEQE 630
Cdd:PTZ00449  575 LSKKPEFPKDPKHPKDPEEPKKPKRPRSaQRPTRPK-SPKLPElldIPKSPKRPESPK--SPKRPPPPQRPSSPERPEGP 651

                          90
                  ....*....|....*...
gi 1622824923 631 PSPGTAkeerKEPENARP 648
Cdd:PTZ00449  652 KIIKSP----KPPKSPKP 665
PHA03247 PHA03247
large tegument protein UL36; Provisional
 556-665 2.71e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  556 RRRLPPPTRQAKSSGPPT-PRAPDQPGTRRPVPPPLAPQRPQLPGPS--PDPDSAHDGQPQAPGKEQSGTGDRHPEQEPS 632
Cdd:PHA03247  2756 RPARPPTTAGPPAPAPPAaPAAGPPRRLTRPAVASLSESRESLPSPWdpADPPAAVLAPAAALPPAASPAGPLPPPTSAQ 2835

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1622824923  633 PGTAKEERKEPENARPWGG--------HPRPTPHAPATLPA 665
Cdd:PHA03247  2836 PTAPPPPPGPPPPSLPLGGsvapggdvRRRPPSRSPAAKPA 2876
dnaA PRK14086
chromosomal replication initiator protein DnaA;
558-655 2.88e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.96  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 558 RLPPPTRQAKS-SGPPTPRAPDQP----GTRRPVP-PPLAPQRPQLPGPSPD-PDsahDGQPQAPGKEQSGTGDRHPEQE 630
Cdd:PRK14086   94 EPAPPPPHARRtSEPELPRPGRRPyegyGGPRADDrPPGLPRQDQLPTARPAyPA---YQQRPEPGAWPRAADDYGWQQQ 170

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1622824923 631 PS-------PGTAKEERKEPENARPWGGHPRP 655
Cdd:PRK14086  171 RLgfpprapYASPASYAPEQERDREPYDAGRP 202
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-669 2.94e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 40.74  E-value: 2.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEE 639
Cdd:PRK07764  703 PAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782

                          90       100       110
                  ....*....|....*....|....*....|
gi 1622824923 640 RKEPENARPwggHPRPTPHAPATLPAFRDL 669
Cdd:PRK07764  783 EEMAEDDAP---SMDDEDRRDAEEVAMELL 809
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 569-661 3.35e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 3.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  569 SGPPTPRAPDQPGTRR--PVPPPLAPQRPQLPGPsPDPDSAHDGQPQAPGKEQsgtgdRHPEQEPSPGTAKEERKEPENA 646
Cdd:PRK10263   753 QQPQQPVAPQQQYQQPqqPVAPQPQYQQPQQPVA-PQPQYQQPQQPVAPQPQY-----QQPQQPVAPQPQYQQPQQPVAP 826

                           90
                   ....*....|....*
gi 1622824923  647 RPWGGHPRPtPHAPA 661
Cdd:PRK10263   827 QPQYQQPQQ-PVAPQ 840
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 557-665 3.47e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.92  E-value: 3.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  557 RRLPPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTG---------DRHP 627
Cdd:PHA03307   101 AREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAAssrqaalplSSPE 180

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1622824923  628 EQEPSPGTAKEERKePENARPWGGHPRPTPHAPATLPA 665
Cdd:PHA03307   181 ETARAPSSPPAEPP-PSTPPAAASPRPPRRSSPISASA 217
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 561-648 3.64e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.84  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  561 PPTRQAKSSGPPTPRAPDQP--GTRRPVPPPLAPQRPQLPgPSPDPDSAHDGQPQAPGKEQsgtgdRHPEQEPSPGTAKE 638
Cdd:PRK10263   758 PVAPQQQYQQPQQPVAPQPQyqQPQQPVAPQPQYQQPQQP-VAPQPQYQQPQQPVAPQPQY-----QQPQQPVAPQPQYQ 831

                           90
                   ....*....|
gi 1622824923  639 ERKEPENARP 648
Cdd:PRK10263   832 QPQQPVAPQP 841
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 563-664 3.88e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 40.52  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 563 TRQAKSSGPPTPRAPDQPGTRRPVP-------PPLAPQRPQLPGPSPDPDSahdgQPQAPGKEQSGTGDR-HPEQEPSPG 634
Cdd:NF033839  273 TKFKKGLTQDTPKEPGNKKPSAPKPgmqpspqPEKKEVKPEPETPKPEVKP----QLEKPKPEVKPQPEKpKPEVKPQLE 348

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824923 635 TAKEE-RKEPENARPwGGHPRPTPHAPATLP 664
Cdd:NF033839  349 TPKPEvKPQPEKPKP-EVKPQPEKPKPEVKP 378
SepH NF040712
septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces ...
 556-666 4.02e-03

septation protein SepH; Septation protein H (SepH) was firstly characterized in Streptomyces venezuelae, and homologs were identified in Mycobacterium smegmatis. SepH contains a N-terminal DUF3071 domain and a conserved C-terminal region. It binds directly to cell division protein FtsZ to stimulate the assembly of FtsZ protofilaments.


Pssm-ID: 468676 [Multi-domain]  Cd Length: 346  Bit Score: 40.14  E-value: 4.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 556 RRRLPPPTRQAkssgpPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGT 635
Cdd:NF040712  196 LRPLATVPRLA-----REPADARPEEVEPAPAAEGAPATDSDPAEAGTPDDLASARRRRAGVEQPEDEPVGPGAAPAAEP 270

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1622824923 636 AKEERKEPENARPWGGHPRPTPHAPATLPAF 666
Cdd:NF040712  271 DEATRDAGEPPAPGAAETPEAAEPPAPAPAA 301
PHA03247 PHA03247
large tegument protein UL36; Provisional
 557-644 4.07e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  557 RRLPPPTRQAKSS--------------GPPTPRAPDQPGTRRPVPPPLAPQRPQLP-GPSPDPDSAHDGQPQAPGKEQSG 621
Cdd:PHA03247   376 KRASLPTRKRRSArhaatpfargpggdDQTRPAAPVPASVPTPAPTPVPASAPPPPaTPLPSAEPGSDDGPAPPPERQPP 455

                           90       100       110
                   ....*....|....*....|....*....|
gi 1622824923  622 TgDRHPEQEPSPGTAKE-------ERKEPE 644
Cdd:PHA03247   456 A-PATEPAPDDPDDATRkaldalrERRPPE 484
PRK11901 PRK11901
hypothetical protein; Reviewed
 569-665 4.26e-03

hypothetical protein; Reviewed


Pssm-ID: 237015 [Multi-domain]  Cd Length: 327  Bit Score: 39.67  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 569 SGPPTPRAPDQPgtrRPVPPPLAPQRPQLPGPSPDPDSAHDGQ---------------PQAPGKEQSGTGDRHPEQEPSP 633
Cdd:PRK11901  120 SAPPISPTPTQA---APPQTPNGQQRIELPGNISDALSQQQGQvnaasqnaqgntstlPTAPATVAPSKGAKVPATAETH 196

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1622824923 634 GTAKEerkEPENARPWGGHPR--PTPHAPATLPA 665
Cdd:PRK11901  197 PTPPQ---KPATKKPAVNHHKtaTVAVPPATSGK 227
dnaA PRK14086
chromosomal replication initiator protein DnaA;
541-665 4.66e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.19  E-value: 4.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 541 GEADVWPRLGGSCSLRR-RLPPPTRQakssgPPTPRAPDQPGTRRPVPPPlAPQRPQLPGPSPDPDSahdgqpQAPGKEQ 619
Cdd:PRK14086  153 PEPGAWPRAADDYGWQQqRLGFPPRA-----PYASPASYAPEQERDREPY-DAGRPEYDQRRRDYDH------PRPDWDR 220

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1622824923 620 SGtGDRHPEQEPSPGTAKEERKEP-ENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK14086  221 PR-RDRTDRPEPPPGAGHVHRGGPgPPERDDAPVVPIRPSAPGPLAA 266
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
560-668 5.68e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.86  E-value: 5.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEE 639
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARP 464

                          90       100
                  ....*....|....*....|....*....
gi 1622824923 640 RKEPENARPWGGHPRPTPHAPATLPAFRD 668
Cdd:PRK12323  465 AAAGPRPVAAAAAAAPARAAPAAAPAPAD 493
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 572-662 6.66e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.75  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 572 PTPRAPDQPGTRRP-VPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKE---QSGTGDrhPEQEPSPGTAKEERK-EPENA 646
Cdd:NF033839  405 PKPEVKPQPEKPKPeVKPQPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkpQPETPK--PEVKPQPEKPKPEVKpQPEKP 482

                          90
                  ....*....|....*.
gi 1622824923 647 RPWGGHPRPTPHAPAT 662
Cdd:NF033839  483 KPDNSKPQADDKKPST 498
BimA_second NF040983
trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia ...
 560-629 7.07e-03

trimeric autotransporter actin-nucleating factor BimA; This HMM describes BimA (Burkholderia intracellular motility A), WP_004266405.1-like proteins in Burkholderia mallei or B. pseudomallei. The term BimA has also been used for WP_011205626.1-like homologs that have a very different N-terminal half.


Pssm-ID: 468913 [Multi-domain]  Cd Length: 382  Bit Score: 39.12  E-value: 7.07e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSahdgqpQAPGKEQSGTGDRHPEQ 629
Cdd:NF040983   96 PPPPPPPPPTPPPPPPPPPPPPPPSPPPPPPPSPPPSPPPPTTTPPT------RTTPSTTTPTPSMHPIQ 159
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 572-664 7.91e-03

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 39.37  E-value: 7.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 572 PTPRAPDQPGTRRPV--PPPLAPQ---RPQLPGPSPD-------PDSAHDGQPQAPgkeqsgtgdrHPEQEPSPGTAKEE 639
Cdd:NF033839  339 PKPEVKPQLETPKPEvkPQPEKPKpevKPQPEKPKPEvkpqpetPKPEVKPQPEKP----------KPEVKPQPEKPKPE 408

                          90       100
                  ....*....|....*....|....*.
gi 1622824923 640 RK-EPENARPwGGHPRPTPHAPATLP 664
Cdd:NF033839  409 VKpQPEKPKP-EVKPQPEKPKPEVKP 433
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 560-637 8.30e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 39.49  E-value: 8.30e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1622824923  560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAK 637
Cdd:PRK12270    48 AAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDEVTPLRGAAA 125
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-661 8.62e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 8.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPgtRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTAKEE 639
Cdd:PRK07764  624 PAAPAPAGAAAAPAEASAAPA--PGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQP 701

                          90       100
                  ....*....|....*....|..
gi 1622824923 640 RKEPENARPWGGHPRPTPHAPA 661
Cdd:PRK07764  702 APAPAATPPAGQADDPAAQPPQ 723
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
562-665 9.02e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 39.09  E-value: 9.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 562 PTRQAKSSGPPTPRApdqpGTRRPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRhpeqEPSPGTAKEERK 641
Cdd:PRK12323  365 PGQSGGGAGPATAAA----APVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPA----RRSPAPEALAAA 436

                          90       100
                  ....*....|....*....|....
gi 1622824923 642 EPENARPWGGHPRPTPhAPATLPA 665
Cdd:PRK12323  437 RQASARGPGGAPAPAP-APAAAPA 459
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 560-665 9.08e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.38  E-value: 9.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923  560 PPPTRQAKSSGPPTPRAPDQPGTRRPVPPPLAPQrPQLPGPSPDPDSAHDGQPQAPgkeqsgtgDRHPEQEPSPGTAKEE 639
Cdd:PHA03307    89 TWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP-PASPPPSPAPDLSEMLRPVGS--------PGPPPAASPPAAGASP 159

                           90       100
                   ....*....|....*....|....*.
gi 1622824923  640 RKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PHA03307   160 AAVASDAASSRQAALPLSSPEETARA 185
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 560-607 9.52e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 38.95  E-value: 9.52e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1622824923 560 PPPTRQAkssgPPTPRAPDQPGTRRPVPPPLAPQRPQLPGPSPDPDSA 607
Cdd:PRK14965  400 PPPAAAP----PVPPAAPARPAAARPAPAPAPPAAAAPPARSADPAAA 443
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 560-665 9.71e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.20  E-value: 9.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622824923 560 PPPTRQAKSSGPPTPRAPDQPGTR---RPVPPPLAPQRPQLPGPSPDPDSAHDGQPQAPGKEQSGTGDRHPEQEPSPGTA 636
Cdd:PRK07764  615 PAAPAAPAAPAAPAPAGAAAAPAEasaAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPA 694

                          90       100
                  ....*....|....*....|....*....
gi 1622824923 637 KEERKEPENARPWGGHPRPTPHAPATLPA 665
Cdd:PRK07764  695 GAAPAQPAPAPAATPPAGQADDPAAQPPQ 723
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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