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Conserved domains on  [gi|1622863674|ref|XP_028689367|]
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Wilms tumor protein isoform X6 [Macaca mulatta]

Protein Classification

SUF4-like and COG5048 domain-containing protein( domain architecture ID 11646583)

SUF4-like and COG5048 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WT1 super family cl03474
Wilm's tumour protein;
3-160 2.45e-102

Wilm's tumour protein;


The actual alignment was detected with superfamily member pfam02165:

Pssm-ID: 460471  Cd Length: 289  Bit Score: 300.64  E-value: 2.45e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674   3 KGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNL 82
Cdd:pfam02165 130 QGYGAVAFDGNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674  83 YQMTSQLECMTWNQMN-LGATLKGHGTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSaSETSEK 159
Cdd:pfam02165 210 YQMASQLECVTWNQMNsLASTIKSHATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRVPGITPPIVKS-SEASEK 288


                  .
gi 1622863674 160 R 160
Cdd:pfam02165 289 R 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-280 7.71e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 7.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674 152 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPF-QCKTCQRK 230
Cdd:COG5048    24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLS 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622863674 231 FSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 280
Cdd:COG5048   102 NSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPL 151
 
Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
3-160 2.45e-102

Wilm's tumour protein;


Pssm-ID: 460471  Cd Length: 289  Bit Score: 300.64  E-value: 2.45e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674   3 KGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNL 82
Cdd:pfam02165 130 QGYGAVAFDGNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674  83 YQMTSQLECMTWNQMN-LGATLKGHGTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSaSETSEK 159
Cdd:pfam02165 210 YQMASQLECVTWNQMNsLASTIKSHATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRVPGITPPIVKS-SEASEK 288


                  .
gi 1622863674 160 R 160
Cdd:pfam02165 289 R 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-280 7.71e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 7.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674 152 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPF-QCKTCQRK 230
Cdd:COG5048    24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLS 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622863674 231 FSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 280
Cdd:COG5048   102 NSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPL 151
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-233 4.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 4.99e-04
                          10        20
                  ....*....|....*....|....*
gi 1622863674 209 LKRHQRRHTGVKPFQCKTCQRKFSR 233
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 199-240 7.13e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 34.84  E-value: 7.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622863674 199 CERRFSRSDQLKRHQR-RHtgvkpFQCKTCQRKFSRSDHLKTH 240
Cdd:cd20908     7 CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
WT1 pfam02165
Wilm's tumour protein;
3-160 2.45e-102

Wilm's tumour protein;


Pssm-ID: 460471  Cd Length: 289  Bit Score: 300.64  E-value: 2.45e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674   3 KGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHEDPMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNL 82
Cdd:pfam02165 130 QGYGAVAFDGNPSYGHTPSHHTPQFSNHSFKHEDTLSPQNSIGEQQYPVPPPVYGCHTPSDSCTGSQALLLRNPYNSDNL 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674  83 YQMTSQLECMTWNQMN-LGATLKGHGTGYESDNHTTPI--LCGAQYRIHTHGVFRGIQDVRRVPGVAPTLVRSaSETSEK 159
Cdd:pfam02165 210 YQMASQLECVTWNQMNsLASTIKSHATSYESDPHSTPMlySCSTQYHIHTHGVFRGIQDVRRVPGITPPIVKS-SEASEK 288


                  .
gi 1622863674 160 R 160
Cdd:pfam02165 289 R 289
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-280 7.71e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 7.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674 152 SASETSEKRPFMCayPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPF-QCKTCQRK 230
Cdd:COG5048    24 LKSLSNAPRPDSC--PNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLS 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1622863674 231 FSRSDHLKTHTRTHTGKTSEKPFSCRWPSCQKKFARSDELVRHHNMHQRN 280
Cdd:COG5048   102 NSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPL 151
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-281 1.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622863674 220 KPFQCKTCQRKFSRSDHLKTHTRTHTGktsEKPFSCRWPSCQKKFARSDELVRHHNMHQRNM 281
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTG---EKPSQCSYSGCDKSFSRPLELSRHLRTHHNNP 90
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
152-234 1.45e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 1.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674 152 SASETSEKRPFMCAYpgCNKRYFKLSHLQMHSRK--HTGE--KPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTC 227
Cdd:COG5048   280 SSSEKGFSLPIKSKQ--CNISFSRSSPLTRHLRSvnHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLL 357


                  ....*..
gi 1622863674 228 QRKFSRS 234
Cdd:COG5048   358 NSSSKFS 364
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-242 1.88e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674 157 SEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSDQLKRHQRRHTGVKPFQCKTCqRKFSRSDH 236
Cdd:COG5048   382 KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSFRRDLD 460


                  ....*.
gi 1622863674 237 LKTHTR 242
Cdd:COG5048   461 LSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 156-245 4.25e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 4.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622863674 156 TSEKRPFMCAYPGCNKRYFKLSHLQMHsRKHTGEKPYQCDFKDCErrfsrsdqlkRHQRRHTGVKPFQCKTCQRKFSRSD 235
Cdd:COG5189   344 VKDGKPYKCPVEGCNKKYKNQNGLKYH-MLHGHQNQKLHENPSPE----------KMNIFSAKDKPYRCEVCDKRYKNLN 412

                          90
                  ....*....|
gi 1622863674 236 HLKTHtRTHT 245
Cdd:COG5189   413 GLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-233 4.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 4.99e-04
                          10        20
                  ....*....|....*....|....*
gi 1622863674 209 LKRHQRRHTGVKPFQCKTCQRKFSR 233
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
178-205 2.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.95e-03
                          10        20
                  ....*....|....*....|....*...
gi 1622863674 178 HLQMHSRKHTGEKPYQCDFkdCERRFSR 205
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 222-244 3.06e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 3.06e-03
                          10        20
                  ....*....|....*....|...
gi 1622863674 222 FQCKTCQRKFSRSDHLKTHTRTH 244
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 199-240 7.13e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 34.84  E-value: 7.13e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1622863674 199 CERRFSRSDQLKRHQR-RHtgvkpFQCKTCQRKFSRSDHLKTH 240
Cdd:cd20908     7 CDREFDDEKILIQHQKaKH-----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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