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Conserved domains on  [gi|1622862141|ref|XP_028689022|]
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type 2 DNA topoisomerase 6 subunit B-like isoform X10 [Macaca mulatta]

Protein Classification

TOP6B-like family protein( domain architecture ID 10633419)

TOP6B-like family protein is a DUF4554 domain-containing protein; similar to Homo sapiens type 2 DNA topoisomerase 6 subunit B-like, a component of a topoisomerase 6 complex specifically required for meiotic recombination

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4554 super family cl20960
Domain of unknown function (DUF4554); This family of proteins is functionally uncharacterized. ...
 54-539 0e+00

Domain of unknown function (DUF4554); This family of proteins is functionally uncharacterized. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.


The actual alignment was detected with superfamily member pfam15091:

Pssm-ID: 464497  Cd Length: 456  Bit Score: 847.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141  54 MTDCLVIKHFLRKIIMVHPKIRFNFSIKVNGILSTEIFGVENEPTLNLGNGIALVVDSQHYVSRPNFGTVESHCSRIHPV 133
Cdd:pfam15091   1 MTDCLVIKHFLRKIIIVHHKIRFNFSVKVNGILSTEIFGVENEPTLNLWNGIALVVGSQHYVSRPKFGTTESHCSRIHPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 134 LGHPVILFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRIYSVS--IFLYGPLGLPLILSTWEQPMTTFFKDTSSL 211
Cdd:pfam15091  81 LGHPVTLSIPDDKAGMGLLGELTLTPAAALCPSPKVFSSQLNRISSVSpyIFLYGPLGLPLVLSDQEQPSTTVFKDTSYF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 212 IDWKKYHLCMVPNLDLNLDRDLVLPDVSYRAESSEGDQSHNMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTAHLN 291
Cdd:pfam15091 161 IDWKKYHLCMVPNLDLNLDRDFVLPDVSYQVESSEEAQSQNMDPQGQTLLLFLFVDFHSGFPVQQMEIWGVHTLLTTHLS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 292 AILVESHSVVQGCIQFTVDQVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFGTKLHK 371
Cdd:pfam15091 241 AILSESHSVVQDSIQFTVDQVLEQHHQAAKAHQKLQASLSVAVNSIMSVLTGSTSSSFRKTCLQALQAADTQEFGTKLHK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 372 VFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDVPDNSSRELLADTNEQAENKRLKRGSLR--MEEMRALHSARAPSP 449
Cdd:pfam15091 321 IFYDITQHQFLHHCSCDMKQQLTPEKKDSAQNTEDAHENSGLELLAETSGQAENKRLKRGSPHqgREEMRTLHSARAPSP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 450 SEAAPRRPEATAAPLTPSGRAAFKAHGRALAPGRVSRGSRLEVteralrregcgrrcgpqaaaegsslraplfpqdvLWL 529
Cdd:pfam15091 401 PESAPRRPEPTAASLTPRGSETRKAHDGAPAPDRASPGGRLED----------------------------------LWL 446

                         490
                  ....*....|
gi 1622862141 530 QEVSNLSEWL 539
Cdd:pfam15091 447 QEVSNLSEWL 456
 
Name Accession Description Interval E-value
DUF4554 pfam15091
Domain of unknown function (DUF4554); This family of proteins is functionally uncharacterized. ...
 54-539 0e+00

Domain of unknown function (DUF4554); This family of proteins is functionally uncharacterized. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.


Pssm-ID: 464497  Cd Length: 456  Bit Score: 847.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141  54 MTDCLVIKHFLRKIIMVHPKIRFNFSIKVNGILSTEIFGVENEPTLNLGNGIALVVDSQHYVSRPNFGTVESHCSRIHPV 133
Cdd:pfam15091   1 MTDCLVIKHFLRKIIIVHHKIRFNFSVKVNGILSTEIFGVENEPTLNLWNGIALVVGSQHYVSRPKFGTTESHCSRIHPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 134 LGHPVILFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRIYSVS--IFLYGPLGLPLILSTWEQPMTTFFKDTSSL 211
Cdd:pfam15091  81 LGHPVTLSIPDDKAGMGLLGELTLTPAAALCPSPKVFSSQLNRISSVSpyIFLYGPLGLPLVLSDQEQPSTTVFKDTSYF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 212 IDWKKYHLCMVPNLDLNLDRDLVLPDVSYRAESSEGDQSHNMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTAHLN 291
Cdd:pfam15091 161 IDWKKYHLCMVPNLDLNLDRDFVLPDVSYQVESSEEAQSQNMDPQGQTLLLFLFVDFHSGFPVQQMEIWGVHTLLTTHLS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 292 AILVESHSVVQGCIQFTVDQVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFGTKLHK 371
Cdd:pfam15091 241 AILSESHSVVQDSIQFTVDQVLEQHHQAAKAHQKLQASLSVAVNSIMSVLTGSTSSSFRKTCLQALQAADTQEFGTKLHK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 372 VFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDVPDNSSRELLADTNEQAENKRLKRGSLR--MEEMRALHSARAPSP 449
Cdd:pfam15091 321 IFYDITQHQFLHHCSCDMKQQLTPEKKDSAQNTEDAHENSGLELLAETSGQAENKRLKRGSPHqgREEMRTLHSARAPSP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 450 SEAAPRRPEATAAPLTPSGRAAFKAHGRALAPGRVSRGSRLEVteralrregcgrrcgpqaaaegsslraplfpqdvLWL 529
Cdd:pfam15091 401 PESAPRRPEPTAASLTPRGSETRKAHDGAPAPDRASPGGRLED----------------------------------LWL 446

                         490
                  ....*....|
gi 1622862141 530 QEVSNLSEWL 539
Cdd:pfam15091 447 QEVSNLSEWL 456
 
Name Accession Description Interval E-value
DUF4554 pfam15091
Domain of unknown function (DUF4554); This family of proteins is functionally uncharacterized. ...
 54-539 0e+00

Domain of unknown function (DUF4554); This family of proteins is functionally uncharacterized. This family of proteins is found in some vertebrates. This family includes human protein C11orf80.


Pssm-ID: 464497  Cd Length: 456  Bit Score: 847.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141  54 MTDCLVIKHFLRKIIMVHPKIRFNFSIKVNGILSTEIFGVENEPTLNLGNGIALVVDSQHYVSRPNFGTVESHCSRIHPV 133
Cdd:pfam15091   1 MTDCLVIKHFLRKIIIVHHKIRFNFSVKVNGILSTEIFGVENEPTLNLWNGIALVVGSQHYVSRPKFGTTESHCSRIHPV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 134 LGHPVILFIPEDVAGMDLLGELILTPAAALCPSPKVSSNQLNRIYSVS--IFLYGPLGLPLILSTWEQPMTTFFKDTSSL 211
Cdd:pfam15091  81 LGHPVTLSIPDDKAGMGLLGELTLTPAAALCPSPKVFSSQLNRISSVSpyIFLYGPLGLPLVLSDQEQPSTTVFKDTSYF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 212 IDWKKYHLCMVPNLDLNLDRDLVLPDVSYRAESSEGDQSHNMDPQGQTLLLFLFVDFHSAFPVQQMEIWGVYTLLTAHLN 291
Cdd:pfam15091 161 IDWKKYHLCMVPNLDLNLDRDFVLPDVSYQVESSEEAQSQNMDPQGQTLLLFLFVDFHSGFPVQQMEIWGVHTLLTTHLS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 292 AILVESHSVVQGCIQFTVDQVLEQHHQAAKAQQKLQASLSVAVNSIMSILTGSTRSSFRKMCLQTLQAADTQEFGTKLHK 371
Cdd:pfam15091 241 AILSESHSVVQDSIQFTVDQVLEQHHQAAKAHQKLQASLSVAVNSIMSVLTGSTSSSFRKTCLQALQAADTQEFGTKLHK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 372 VFREITQHQFLHHCSCEVKQQLTLEKKDSAQGTEDVPDNSSRELLADTNEQAENKRLKRGSLR--MEEMRALHSARAPSP 449
Cdd:pfam15091 321 IFYDITQHQFLHHCSCDMKQQLTPEKKDSAQNTEDAHENSGLELLAETSGQAENKRLKRGSPHqgREEMRTLHSARAPSP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622862141 450 SEAAPRRPEATAAPLTPSGRAAFKAHGRALAPGRVSRGSRLEVteralrregcgrrcgpqaaaegsslraplfpqdvLWL 529
Cdd:pfam15091 401 PESAPRRPEPTAASLTPRGSETRKAHDGAPAPDRASPGGRLED----------------------------------LWL 446

                         490
                  ....*....|
gi 1622862141 530 QEVSNLSEWL 539
Cdd:pfam15091 447 QEVSNLSEWL 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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