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Conserved domains on  [gi|1562407581|ref|XP_027782351|]
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LOW QUALITY PROTEIN: reelin domain-containing protein 1 [Marmota flaviventris]

Protein Classification

Reeler domain-containing protein( domain architecture ID 10170792)

Reeler N-terminal domain-containing protein similar to extracellular matrix protein F-spondin that mediates axon guidance during neuronal development, and to putative defense proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 32-163 1.15e-42

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


:

Pssm-ID: 260081  Cd Length: 135  Bit Score: 149.07  E-value: 1.15e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562407581  32 ACEDM-QPRHIQAQPQHSSSHHLTIHTSrSYSPGDKIPVTVRSS--LDFMGFLLQARRVSDHQTAGTFVLIPPR-SQLIT 107
Cdd:cd08544     1 ACTDMpVPGHGGDPQTTPSPYSITVSGN-TYKPGQTYTVTLSGSrpTPFRGFLLQARDASSNEPVGTFQLPPDSgTKLLT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1562407581 108 CFEEADAVTHSDKSPKRNLSFVWKAPAEPVGDIRFLLSVVQSYFVYWARIESAVVS 163
Cdd:cd08544    80 CCPSGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135
 
Name Accession Description Interval E-value
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 32-163 1.15e-42

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


Pssm-ID: 260081  Cd Length: 135  Bit Score: 149.07  E-value: 1.15e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562407581  32 ACEDM-QPRHIQAQPQHSSSHHLTIHTSrSYSPGDKIPVTVRSS--LDFMGFLLQARRVSDHQTAGTFVLIPPR-SQLIT 107
Cdd:cd08544     1 ACTDMpVPGHGGDPQTTPSPYSITVSGN-TYKPGQTYTVTLSGSrpTPFRGFLLQARDASSNEPVGTFQLPPDSgTKLLT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1562407581 108 CFEEADAVTHSDKSPKRNLSFVWKAPAEPVGDIRFLLSVVQSYFVYWARIESAVVS 163
Cdd:cd08544    80 CCPSGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135
Reeler pfam02014
Reeler domain;
33-154 2.75e-42

Reeler domain;


Pssm-ID: 460411  Cd Length: 130  Bit Score: 147.89  E-value: 2.75e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562407581  33 CEDMQPRHIQAQPQHSSSHHLTIHTSRSYSPGDKIPVTVRSSL---DFMGFLLQARRVSDHQTA--GTFVLIPP--RSQL 105
Cdd:pfam02014   1 CSDMTPQHGNAPQTSPPSPYTITVSSTSYRPGETITVTLSGASggpSFKGFLLQARDADSGDPDpvGSFSLPDDadTKFL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1562407581 106 ITCFEEADAVTHSDKSPKRNLSFVWKAPAEPVGDIRFLLSVVQSYFVYW 154
Cdd:pfam02014  81 LDCSGKGNAVTHSNTNKKSSVTVTWTAPASGSGCVVFRATVVQNYDTFW 129
 
Name Accession Description Interval E-value
Reeler cd08544
Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This ...
 32-163 1.15e-42

Reeler, the N-terminal domain of reelin, F-spondin, and a variety of other proteins; This domain is found at the N-terminus of F-spondin, a protein attached to the extracellular matrix, which plays roles in neuronal development and vascular remodelling. The F-spondin reeler domain has been reported to bind heparin. The reeler domain is also found at the N-terminus of reelin, an extracellular glycoprotein involved in the development of the brain cortex, and in a variety of other eukaryotic proteins with different domain architectures, including the animal ferric-chelate reductase 1 or stromal cell-derived receptor 2, a member of the cytochrome B561 family, which reduces ferric iron before its transport from the endosome to the cytoplasm. Also included is the insect putative defense protein 1, which is expressed upon bacterial infection and appears to contain a single reeler domain.


Pssm-ID: 260081  Cd Length: 135  Bit Score: 149.07  E-value: 1.15e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562407581  32 ACEDM-QPRHIQAQPQHSSSHHLTIHTSrSYSPGDKIPVTVRSS--LDFMGFLLQARRVSDHQTAGTFVLIPPR-SQLIT 107
Cdd:cd08544     1 ACTDMpVPGHGGDPQTTPSPYSITVSGN-TYKPGQTYTVTLSGSrpTPFRGFLLQARDASSNEPVGTFQLPPDSgTKLLT 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1562407581 108 CFEEADAVTHSDKSPKRNLSFVWKAPAEPVGDIRFLLSVVQSYFVYWARIESAVVS 163
Cdd:cd08544    80 CCPSGNAVTHTNNSPKTSVTVTWKAPSNGSGCVTFRATVVQSYDVFWVDVLSKTLC 135
Reeler pfam02014
Reeler domain;
33-154 2.75e-42

Reeler domain;


Pssm-ID: 460411  Cd Length: 130  Bit Score: 147.89  E-value: 2.75e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1562407581  33 CEDMQPRHIQAQPQHSSSHHLTIHTSRSYSPGDKIPVTVRSSL---DFMGFLLQARRVSDHQTA--GTFVLIPP--RSQL 105
Cdd:pfam02014   1 CSDMTPQHGNAPQTSPPSPYTITVSSTSYRPGETITVTLSGASggpSFKGFLLQARDADSGDPDpvGSFSLPDDadTKFL 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1562407581 106 ITCFEEADAVTHSDKSPKRNLSFVWKAPAEPVGDIRFLLSVVQSYFVYW 154
Cdd:pfam02014  81 LDCSGKGNAVTHSNTNKKSSVTVTWTAPASGSGCVVFRATVVQNYDTFW 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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