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Conserved domains on  [gi|1432329396|ref|XP_025706748|]
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lipase member K isoform X1 [Callorhinus ursinus]

Protein Classification

lipase family protein( domain architecture ID 706631)

lipase family protein that may function as a lipase, catalyzing the hydrolysis of ester bonds of insoluble substrates such a triglycerides

EC:  3.1.1.-
Gene Ontology:  GO:0016298|GO:0016788|GO:0006629

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PLN02872 super family cl28691
triacylglycerol lipase
36-390 1.23e-61

triacylglycerol lipase


The actual alignment was detected with superfamily member PLN02872:

Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 203.56  E-value: 1.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  36 SQIISYWGYPCEEYDVVTEDGYVLGIYRIPSGRGCPRATPRPVVYLQHGLIASASNWICNVPNNSLAFLLADTGYDVWMG 115
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWVG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 116 NSRGNTWSRKHLKLSPKSREYWAFSVDEMANYDLPATINFIVEKTgQEQLYYVGHSQGTTIAFIAFsTNPELAKRIKIFF 195
Cdd:PLN02872  114 NVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAAA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 196 ALAPVVTVKYTQSPMkkltaLSREVvkALFGDKMFYP---HTV-FDQFIATKVCNRKLFRHI-CSNFLFTLSGfdpTN-- 268
Cdd:PLN02872  192 LLCPISYLDHVTAPL-----VLRMV--FMHLDQMVVAmgiHQLnFRSDVLVKLLDSICEGHMdCNDLLTSITG---TNcc 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 269 LNMSRLDVYLAQSFAGTSVQNMLHWAQAANSGLFQAFDWGNPdQNMMHFHQLTPPVYDVTKMEVPTAVWS--GGHDRVAD 346
Cdd:PLN02872  262 FNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLAD 340
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1432329396 347 VRDVENL---LPKITRLIYyklISHYNHVDFYLGQDAPQEIYQDLIR 390
Cdd:PLN02872  341 VTDVEHTlaeLPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMIQ 384
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
36-390 1.23e-61

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 203.56  E-value: 1.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  36 SQIISYWGYPCEEYDVVTEDGYVLGIYRIPSGRGCPRATPRPVVYLQHGLIASASNWICNVPNNSLAFLLADTGYDVWMG 115
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWVG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 116 NSRGNTWSRKHLKLSPKSREYWAFSVDEMANYDLPATINFIVEKTgQEQLYYVGHSQGTTIAFIAFsTNPELAKRIKIFF 195
Cdd:PLN02872  114 NVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAAA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 196 ALAPVVTVKYTQSPMkkltaLSREVvkALFGDKMFYP---HTV-FDQFIATKVCNRKLFRHI-CSNFLFTLSGfdpTN-- 268
Cdd:PLN02872  192 LLCPISYLDHVTAPL-----VLRMV--FMHLDQMVVAmgiHQLnFRSDVLVKLLDSICEGHMdCNDLLTSITG---TNcc 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 269 LNMSRLDVYLAQSFAGTSVQNMLHWAQAANSGLFQAFDWGNPdQNMMHFHQLTPPVYDVTKMEVPTAVWS--GGHDRVAD 346
Cdd:PLN02872  262 FNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLAD 340
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1432329396 347 VRDVENL---LPKITRLIYyklISHYNHVDFYLGQDAPQEIYQDLIR 390
Cdd:PLN02872  341 VTDVEHTlaeLPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMIQ 384
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
35-95 1.34e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 106.08  E-value: 1.34e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1432329396  35 ISQIISYWGYPCEEYDVVTEDGYVLGIYRIPSGRG-CPRATPRPVVYLQHGLIASASNWICN 95
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNnSNGKGGKPVVLLQHGLLASSDNWVTN 62
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
47-191 3.81e-09

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 56.55  E-value: 3.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  47 EEYDVVTEDGYVLGIYRIPsgrgcPRATPRPVVYLQHGLIASASNWicnvpnNSLAFLLADTGYDVWMGNSRGntwsrkH 126
Cdd:COG2267     4 RLVTLPTRDGLRLRGRRWR-----PAGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRG------H 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1432329396 127 lKLSPKSREYWAfSVDEMANyDLPATINFIVEKTGQeQLYYVGHSQGTTIAFIAFSTNPELAKRI 191
Cdd:COG2267    67 -GRSDGPRGHVD-SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMGGLIALLYAARYPDRVAGL 127
 
Name Accession Description Interval E-value
PLN02872 PLN02872
triacylglycerol lipase
36-390 1.23e-61

triacylglycerol lipase


Pssm-ID: 215470 [Multi-domain]  Cd Length: 395  Bit Score: 203.56  E-value: 1.23e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  36 SQIISYWGYPCEEYDVVTEDGYVLGIYRIPSGRGCPRATPRPVVYLQHGLIASASNWICNVPNNSLAFLLADTGYDVWMG 115
Cdd:PLN02872   34 AQLIHPAGYSCTEHTIQTKDGYLLALQRVSSRNPRLGSQRGPPVLLQHGLFMAGDAWFLNSPEQSLGFILADHGFDVWVG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 116 NSRGNTWSRKHLKLSPKSREYWAFSVDEMANYDLPATINFIVEKTgQEQLYYVGHSQGTTIAFIAFsTNPELAKRIKIFF 195
Cdd:PLN02872  114 NVRGTRWSYGHVTLSEKDKEFWDWSWQELALYDLAEMIHYVYSIT-NSKIFIVGHSQGTIMSLAAL-TQPNVVEMVEAAA 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 196 ALAPVVTVKYTQSPMkkltaLSREVvkALFGDKMFYP---HTV-FDQFIATKVCNRKLFRHI-CSNFLFTLSGfdpTN-- 268
Cdd:PLN02872  192 LLCPISYLDHVTAPL-----VLRMV--FMHLDQMVVAmgiHQLnFRSDVLVKLLDSICEGHMdCNDLLTSITG---TNcc 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 269 LNMSRLDVYLAQSFAGTSVQNMLHWAQAANSGLFQAFDWGNPdQNMMHFHQLTPPVYDVTKMEVPTAVWS--GGHDRVAD 346
Cdd:PLN02872  262 FNASRIDYYLEYEPHPSSVKNLRHLFQMIRKGTFAHYDYGIF-KNLKLYGQVNPPAFDLSLIPKSLPLWMgyGGTDGLAD 340
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1432329396 347 VRDVENL---LPKITRLIYyklISHYNHVDFYLGQDAPQEIYQDLIR 390
Cdd:PLN02872  341 VTDVEHTlaeLPSKPELLY---LENYGHIDFLLSTSAKEDVYNHMIQ 384
Abhydro_lipase pfam04083
Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an ...
35-95 1.34e-28

Partial alpha/beta-hydrolase lipase region; This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.


Pssm-ID: 461162 [Multi-domain]  Cd Length: 63  Bit Score: 106.08  E-value: 1.34e-28
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1432329396  35 ISQIISYWGYPCEEYDVVTEDGYVLGIYRIPSGRG-CPRATPRPVVYLQHGLIASASNWICN 95
Cdd:pfam04083   1 VSEIIRYYGYPVEEHEVTTEDGYILTLHRIPAGRNnSNGKGGKPVVLLQHGLLASSDNWVTN 62
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
77-377 1.77e-23

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 97.96  E-value: 1.77e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  77 PVVYLQHGLIASASNWICNVPNnslaflLADTGYDVWMGNSRGNTWSRKHLKLSpksreywAFSVDEMANYdlpatINFI 156
Cdd:pfam00561   1 PPVLLLHGLPGSSDLWRKLAPA------LARDGFRVIALDLRGFGKSSRPKAQD-------DYRTDDLAED-----LEYI 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 157 VEKTGQEQLYYVGHSQGTTIAFIAFSTNPELAKRIkiffalapvvtvkYTQSPMKKLTALSREVVKALFGDKMFYPHTVF 236
Cdd:pfam00561  63 LEALGLEKVNLVGHSMGGLIALAYAAKYPDRVKAL-------------VLLGALDPPHELDEADRFILALFPGFFDGFVA 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 237 DQF---IATKVCNRKLFRHICSNFLFTLsgfDPTNLNMSRLDVYLAQSFAGTSVQNMLHWAQAANSGLFQAFDWgnpdqn 313
Cdd:pfam00561 130 DFApnpLGRLVAKLLALLLLRLRLLKAL---PLLNKRFPSGDYALAKSLVTGALLFIETWSTELRAKFLGRLDE------ 200
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1432329396 314 mmhfhqltppvydvtkmevPTAVWSGGHDRVADVRDVENlLPKITRLIYYKLISHYNHVDFYLG 377
Cdd:pfam00561 201 -------------------PTLIIWGDQDPLVPPQALEK-LAQLFPNARLVVIPDAGHFAFLEG 244
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
47-191 3.81e-09

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 56.55  E-value: 3.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  47 EEYDVVTEDGYVLGIYRIPsgrgcPRATPRPVVYLQHGLIASASNWicnvpnNSLAFLLADTGYDVWMGNSRGntwsrkH 126
Cdd:COG2267     4 RLVTLPTRDGLRLRGRRWR-----PAGSPRGTVVLVHGLGEHSGRY------AELAEALAAAGYAVLAFDLRG------H 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1432329396 127 lKLSPKSREYWAfSVDEMANyDLPATINFIVEKTGQeQLYYVGHSQGTTIAFIAFSTNPELAKRI 191
Cdd:COG2267    67 -GRSDGPRGHVD-SFDDYVD-DLRAALDALRARPGL-PVVLLGHSMGGLIALLYAARYPDRVAGL 127
COG4757 COG4757
Predicted alpha/beta hydrolase [General function prediction only];
47-196 1.65e-07

Predicted alpha/beta hydrolase [General function prediction only];


Pssm-ID: 443790 [Multi-domain]  Cd Length: 289  Bit Score: 52.19  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  47 EEYDVVTEDGYVLGIYRIPsgrgcPRATPRPVVylqhgLIASASNwicnVPN---NSLAFLLADTGYDVW------MGNS 117
Cdd:COG4757     8 ESVTITAADGYPLAARLFP-----PAGPPRAVV-----LINPATG----VPQrfyRPFARYLAERGFAVLtydyrgIGLS 73
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1432329396 118 RgntwsrkhlklsPKSREYWAFSVDEMANYDLPATINFIVEKTGQEQLYYVGHSQGTTIafIAFSTNPELAKRIkIFFA 196
Cdd:COG4757    74 R------------PGSLRGFDAGYRDWGELDLPAVLDALRARFPGLPLLLVGHSLGGQL--LGLAPNAERVDRL-VTVA 137
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
71-177 5.14e-07

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 47.90  E-value: 5.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  71 PRATPRPVVYLqHGLIASASNWicnvpnNSLAFLLADTGYDVWmgnsrgnTWSrkhlkLSPKSReywafSVDEMANYdLP 150
Cdd:COG1075     1 YAATRYPVVLV-HGLGGSAASW------APLAPRLRAAGYPVY-------ALN-----YPSTNG-----SIEDSAEQ-LA 55
                          90       100
                  ....*....|....*....|....*..
gi 1432329396 151 ATINFIVEKTGQEQLYYVGHSQGTTIA 177
Cdd:COG1075    56 AFVDAVLAATGAEKVDLVGHSMGGLVA 82
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
75-224 2.02e-04

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 42.59  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396  75 PRPVVYLQHGLiASASNWICNvpnnsLAFLLADTGYDVWMGNSRGntwsrkHLKlSPKSREYWAfSVDEMANyDLPATIN 154
Cdd:pfam12146   3 PRAVVVLVHGL-GEHSGRYAH-----LADALAAQGFAVYAYDHRG------HGR-SDGKRGHVP-SFDDYVD-DLDTFVD 67
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1432329396 155 FIVEKTGQEQLYYVGHSQGTTIAFI-----------------AFSTNPELAKRIKIFFA-LAPVVTVKYTQSPMKKLTAL 216
Cdd:pfam12146  68 KIREEHPGLPLFLLGHSMGGLIAALyalrypdkvdglilsapALKIKPYLAPPILKLLAkLLGKLFPRLRVPNNLLPDSL 147
                         170
                  ....*....|
gi 1432329396 217 SR--EVVKAL 224
Cdd:pfam12146 148 SRdpEVVAAY 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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