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Conserved domains on  [gi|1390643671|ref|XP_025016100|]
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sonic hedgehog protein isoform X2 [Tetranychus urticae]

Protein Classification

Hint domain-containing protein( domain architecture ID 12014164)

Hint (Hedgehog/INTein) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 38-184 7.03e-106

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


:

Pssm-ID: 460055  Cd Length: 161  Bit Score: 305.45  E-value: 7.03e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390643671  38 KTTPLVLEQHIPNVSENTLSASGPSEGKINETDSRFTKLVPNYNPDIVFKDEEGTGIDRIMTTRLKEKLDILASLVQNHW 117
Cdd:pfam01085  15 KLTPLVYKQHVPNVSENTLGASGPSEGKITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQW 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390643671 118 PGIKLRVIEAWDDGSQFNPDSLHYEGRAADITTSDKDNSKYGVLARLAVIAGFDWVLYESRYHVHVS 184
Cdd:pfam01085  95 PGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint super family cl25982
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 186-240 3.63e-06

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


The actual alignment was detected with superfamily member pfam01079:

Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 46.86  E-value: 3.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390643671 186 KSDKAALSRSEGCFTGDSLVYTRTGPV-ALSKVNVGQEILSLDSNGQFTYTT-QRFM 240
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRkPMSELQPGDRVLAMDGGGQVVYSPvLMFL 57
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 38-184 7.03e-106

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 305.45  E-value: 7.03e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390643671  38 KTTPLVLEQHIPNVSENTLSASGPSEGKINETDSRFTKLVPNYNPDIVFKDEEGTGIDRIMTTRLKEKLDILASLVQNHW 117
Cdd:pfam01085  15 KLTPLVYKQHVPNVSENTLGASGPSEGKITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQW 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390643671 118 PGIKLRVIEAWDDGSQFNPDSLHYEGRAADITTSDKDNSKYGVLARLAVIAGFDWVLYESRYHVHVS 184
Cdd:pfam01085  95 PGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 186-240 3.63e-06

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 46.86  E-value: 3.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390643671 186 KSDKAALSRSEGCFTGDSLVYTRTGPV-ALSKVNVGQEILSLDSNGQFTYTT-QRFM 240
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRkPMSELQPGDRVLAMDGGGQVVYSPvLMFL 57
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 197-227 2.81e-03

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 36.48  E-value: 2.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1390643671  197 GCFTGDSLVYT-RTGPVALSKVNVGQEILSLD 227
Cdd:smart00306   1 GCFPGDTLVLTeDGGIKKIEELEEGDKVLALD 32
 
Name Accession Description Interval E-value
HH_signal pfam01085
Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. ...
 38-184 7.03e-106

Hedgehog amino-terminal signalling domain; For the carboxyl Hint module, see pfam01079. Hedgehog is a family of secreted signal molecules required for embryonic cell differentiation.


Pssm-ID: 460055  Cd Length: 161  Bit Score: 305.45  E-value: 7.03e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390643671  38 KTTPLVLEQHIPNVSENTLSASGPSEGKINETDSRFTKLVPNYNPDIVFKDEEGTGIDRIMTTRLKEKLDILASLVQNHW 117
Cdd:pfam01085  15 KLTPLVYKQHVPNVSENTLGASGPSEGKITRNSPRFKELVPNYNPDIIFRDEEGTGADRLMTKRCKDKLNILAILVMNQW 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1390643671 118 PGIKLRVIEAWDDGSQFNPDSLHYEGRAADITTSDKDNSKYGVLARLAVIAGFDWVLYESRYHVHVS 184
Cdd:pfam01085  95 PGVKLRVTEAWDEDGHHPPDSLHYEGRAVDITTSDRDRSKYGMLARLAVEAGFDWVYYESRAHIHCS 161
Hint pfam01079
Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not ...
 186-240 3.63e-06

Hint module; This is an alignment of the Hint module in the Hedgehog proteins. It does not include any Inteins which also possess the Hint module.


Pssm-ID: 460051 [Multi-domain]  Cd Length: 212  Bit Score: 46.86  E-value: 3.63e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390643671 186 KSDKAALSRSEGCFTGDSLVYTRTGPV-ALSKVNVGQEILSLDSNGQFTYTT-QRFM 240
Cdd:pfam01079   1 KAEHSVAAKTGGCFPGDATVTLEDGGRkPMSELQPGDRVLAMDGGGQVVYSPvLMFL 57
Peptidase_M15_3 pfam08291
Peptidase M15;
136-184 1.63e-03

Peptidase M15;


Pssm-ID: 429903  Cd Length: 109  Bit Score: 37.33  E-value: 1.63e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1390643671 136 PDSLHYEGRAADITTSDKDNSKygvLARLAVIAGFDWVL-YESRYHVHVS 184
Cdd:pfam08291  63 SQSQHLTGLAADITVGGVNFEE---LAQILRNAGPTGVGiYRHNRFVHVD 109
HintN smart00306
Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. ...
 197-227 2.81e-03

Hint (Hedgehog/Intein) domain N-terminal region; Hedgehog/Intein domain, N-terminal region. Domain has been split to accommodate large insertions of endonucleases.


Pssm-ID: 197642 [Multi-domain]  Cd Length: 100  Bit Score: 36.48  E-value: 2.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1390643671  197 GCFTGDSLVYT-RTGPVALSKVNVGQEILSLD 227
Cdd:smart00306   1 GCFPGDTLVLTeDGGIKKIEELEEGDKVLALD 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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