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Conserved domains on  [gi|1370475971|ref|XP_024307492|]
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transducin-like enhancer protein 6 isoform X3 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-388 1.06e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 109 ILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlASVS 187
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTL-KGHT------GPVRDVAASADGTYLASGSSD-KTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 188 VWDLAAPSLHVKEQLPCAGLNCqaLDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGG 265
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 266 PDACLRCWDQRTiMKPLE--YQFKSQIMSLSHSPQEDWVLLGMANGQ--QWLQSTSGSQRHMVGQKDSViLSVKFSPFGQ 341
Cdd:cd00200   155 QDGTIKLWDLRT-GKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTikLWDLSTGKCLGTLRGHENGV-NSVAFSPDGY 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370475971 342 WWASVGMDDFLGVYSMPAGTKVFEVPE-MSPVTCCDVSSNNRLVVTGS 388
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGS 280
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-388 1.06e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 109 ILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlASVS 187
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTL-KGHT------GPVRDVAASADGTYLASGSSD-KTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 188 VWDLAAPSLHVKEQLPCAGLNCqaLDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGG 265
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 266 PDACLRCWDQRTiMKPLE--YQFKSQIMSLSHSPQEDWVLLGMANGQ--QWLQSTSGSQRHMVGQKDSViLSVKFSPFGQ 341
Cdd:cd00200   155 QDGTIKLWDLRT-GKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTikLWDLSTGKCLGTLRGHENGV-NSVAFSPDGY 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370475971 342 WWASVGMDDFLGVYSMPAGTKVFEVPE-MSPVTCCDVSSNNRLVVTGS 388
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGS 280
WD40 COG2319
WD40 repeat [General function prediction only];
220-389 1.53e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 220 LAFASFtSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWDQRT--IMKPLEYQfKSQIMSLSH 295
Cdd:COG2319   219 LASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATgeLLRTLTGH-SGGVNSVAF 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 296 SPQEDWVLLGMANGQ-QWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMS-PVT 373
Cdd:COG2319   297 SPDGKLLASGSDDGTvRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVT 376

                         170
                  ....*....|....*.
gi 1370475971 374 CCDVSSNNRLVVTGSG 389
Cdd:COG2319   377 SVAFSPDGRTLASGSA 392
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-388 1.06e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.83  E-value: 1.06e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 109 ILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlASVS 187
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKLLATGSGDGtIKVWDLETGELLRTL-KGHT------GPVRDVAASADGTYLASGSSD-KTIR 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 188 VWDLAAPSLHVKEQLPCAGLNCqaLDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYN--IWTGG 265
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtfVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 266 PDACLRCWDQRTiMKPLE--YQFKSQIMSLSHSPQEDWVLLGMANGQ--QWLQSTSGSQRHMVGQKDSViLSVKFSPFGQ 341
Cdd:cd00200   155 QDGTIKLWDLRT-GKCVAtlTGHTGEVNSVAFSPDGEKLLSSSSDGTikLWDLSTGKCLGTLRGHENGV-NSVAFSPDGY 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1370475971 342 WWASVGMDDFLGVYSMPAGTKVFEVPE-MSPVTCCDVSSNNRLVVTGS 388
Cdd:cd00200   233 LLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGS 280
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 211-389 6.07e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.82  E-value: 6.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 211 ALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSI--VVKGYNIWTGGPDACLRCWDQRTIMKPLEY-QFK 287
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVaaSADGTYLASGSSDKTIRLWDLETGECVRTLtGHT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 288 SQIMSLSHSPQEDWVLLGMANGQQWLQSTSGSQRHMV--GQKDSViLSVKFSPFGQWWASVGMDDFLGVYSMPAGT--KV 363
Cdd:cd00200    94 SYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlrGHTDWV-NSVAFSPDGTFVASSSQDGTIKLWDLRTGKcvAT 172

                         170       180
                  ....*....|....*....|....*.
gi 1370475971 364 FEVPEmSPVTCCDVSSNNRLVVTGSG 389
Cdd:cd00200   173 LTGHT-GEVNSVAFSPDGEKLLSSSS 197
WD40 COG2319
WD40 repeat [General function prediction only];
220-389 1.53e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 220 LAFASFtSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWDQRT--IMKPLEYQfKSQIMSLSH 295
Cdd:COG2319   219 LASGSA-DGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLWDLATgeLLRTLTGH-SGGVNSVAF 296

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 296 SPQEDWVLLGMANGQ-QWLQSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVFEVPEMS-PVT 373
Cdd:COG2319   297 SPDGKLLASGSDDGTvRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTgAVT 376

                         170
                  ....*....|....*.
gi 1370475971 374 CCDVSSNNRLVVTGSG 389
Cdd:COG2319   377 SVAFSPDGRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
211-391 1.37e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 211 ALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWDQRTimKPLEYQFK- 287
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLWDLAT--GKLLRTLTg 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 288 --SQIMSLSHSPQEDWVLLGMANGQQWL-QSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMDDFLGVYSMPAGTKVF 364
Cdd:COG2319   161 hsGAVTSVAFSPDGKLLASGSDDGTVRLwDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                         170       180
                  ....*....|....*....|....*...
gi 1370475971 365 EVP-EMSPVTCCDVSSNNRLVVTGSGEH 391
Cdd:COG2319   241 TLTgHSGSVRSVAFSPDGRLLASGSADG 268
WD40 COG2319
WD40 repeat [General function prediction only];
220-349 1.77e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 220 LAFASFtSGVVRIWDLRDQSVVRDLKGYPDGVKSIVV--KGYNIWTGGPDACLRCWD--QRTIMKPLEyQFKSQIMSLSH 295
Cdd:COG2319   261 LASGSA-DGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLLASGSDDGTVRLWDlaTGKLLRTLT-GHTGAVRSVAF 338

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1370475971 296 SPQEDWVLLGMANGQQWL-QSTSGSQRHMVGQKDSVILSVKFSPFGQWWASVGMD 349
Cdd:COG2319   339 SPDGKTLASGSDDGTVRLwDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 106-274 3.47e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 3.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 106 KMRILAHGELVLATAISSFTRHVFTCGRRG-IKVWSLTGQVAEDRFpESHLpiqtpgAFLRTCLLSSNSRSLLTGGYNlA 184
Cdd:cd00200   128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGtIKLWDLRTGKCVATL-TGHT------GEVNSVAFSPDGEKLLSSSSD-G 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475971 185 SVSVWDLAAPSLHvkEQLPCAGLNCQALDANLDANLAFASFTSGVVRIWDLRDQSVVRDLKGYPDGVKSIVVKGYNIW-- 262
Cdd:cd00200   200 TIKLWDLSTGKCL--GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRla 277

                         170
                  ....*....|..
gi 1370475971 263 TGGPDACLRCWD 274
Cdd:cd00200   278 SGSADGTIRIWD 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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