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Conserved domains on  [gi|1370475168|ref|XP_024307286|]
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lysosomal alpha-mannosidase isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_38C pfam07748
Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases are key enzymes of ...
240-456 3.04e-65

Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases are key enzymes of carbohydrate metabolism.


:

Pssm-ID: 400208 [Multi-domain]  Cd Length: 204  Bit Score: 213.27  E-value: 3.04e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168 240 IENEHIRATFDPDTGLLMEIMNMNQ--QLLLPVRQTFFWYNASIGDnesdqaSGAYIFRP-NQQKPLPVSRWAQIHLVKT 316
Cdd:pfam07748   1 LENGFLKVEFDNDTGTLTSIYDKELsrEVLAEVGNQFGLYEDIPGY------SDAWDFRPfYEAKPLEVDEQSIEVVEDG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168 317 PLVQEVHQNFSAW---CSQVVRLYPGQRHLELEWSVGPIpvgdtwGKEVISRFDTPLETKGRFYTDSNGREILERRRDYR 393
Cdd:pfam07748  75 PLVAEVHVKFKIGgseISQVIRLYKGSPRLEFETTVDWH------EREVLLKVAFPIDSQAEFATDENGFGVIKRPTHQN 148
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370475168 394 PTWKLNQTEPvagnyyPVNTRIYITDGNMQLTVLTDRSQGGSSLrDGSLELMVHRRLLKDDGR 456
Cdd:pfam07748 149 TSWDLARFEV------PIHSWVDLSDSNYGVSLLNDSKYGGSSL-DGQLELSLLRRPLYPDPR 204
PLN02701 super family cl26659
alpha-mannosidase
9-633 2.15e-57

alpha-mannosidase


The actual alignment was detected with superfamily member PLN02701:

Pssm-ID: 178304 [Multi-domain]  Cd Length: 1050  Bit Score: 209.65  E-value: 2.15e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168    9 DFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVG-----PYGSGDSAPL-NEAMAVLQHHDAV 82
Cdd:PLN02701   375 DFFTYADRQQDYWSGYYVSRPFFKAVDRVLEQTLRAAEILFSFLLGYCRRFqceklPTSFSYKLTAaRRNLALFQHHDGV 454
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168   83 SGTSRQHVANDYARQLAAGW--------GPCEVLLSNALARLRGFKDHFTFCQQ--------LNISICPLSQTAARfqVI 146
Cdd:PLN02701   455 TGTAKDHVVVDYGTRMHTSLqdlqifmsAAVEVLLGIRHEKSDQTPSWFEPEQSrskydmlpVHKVINLREGKAHR--VV 532
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  147 VYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVvifpsSDSQAHPPELLFS--------ASLPALGFSTYSVAQ--- 215
Cdd:PLN02701   533 FFNPLEQTREEVVMVVVDRPAVCVFDSNWTCVPSQI-----SPEWQHDGEKLFTgrhrlywkASVPALGLETYFIANgnv 607
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  216 -----VPRWKPQARAPQPIP-----RRSWSPALTIE--NEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYnasigd 283
Cdd:PLN02701   608 scekaVPAKLKVFNSDDKFPcpepySCSKLEGDTVEisNSHQTLGFDVKTGLLRKIKIHKNGSETVVGEEIGMY------ 681
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  284 neSDQASGAYIFRPN-QQKPLpVSRWAQIHLVKTPLVQEVH-QNFSAW----CSQVVRLYPGQRHL-----ELEWSVGPI 352
Cdd:PLN02701   682 --SSQGSGAYLFKPDgEAQPI-VQAGGLVVVSEGPLVQEVHsVPKTKWekspLSRSTRLYHGGKSVqdlsvEKEYHVELL 758
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  353 pvGDTWG-KEVISRFDTPLETKGRFYTDSNGREILeRRRDYRPTwklnqtePVAGNYYPVNTRIYITDGNMQ-LTVLTDR 430
Cdd:PLN02701   759 --GHDFNdKELIVRFKTDIDNKRVFYSDLNGFQMS-RRETYDKI-------PLQGNYYPMPSLAFLQGSNGQrFSVHSRQ 828
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  431 SQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVrgRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVlapggGA 510
Cdd:PLN02701   829 SLGVASLKNGWLEIMLDRRLVQDDGRGLGQGVMDNRPMNVV--FHLLLESNISSSPPASNPLPLQPSLLSHRV-----GA 901
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  511 AYN---------------LGAPPRTQFSGLRRDLPPSVHLLTLASWGP--EMVLLRLEHQFAV-----GEDS-----GRN 563
Cdd:PLN02701   902 HLNypmhaflakkpqatsVENPQDTSFAPLAKPLPCDLHIVNFKVPRPskYSQQEAEDPRFGLllqrrGWDSsycrkGGT 981
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370475168  564 LSAPVT---LNLRDLFSTFTITRLQETTLvaNQLREAASRLKWTTNTGPTPHQtpyqldpANITLEPMEIRTF 633
Cdd:PLN02701   982 QCTTLAnepVNLFDMFKDLAVSKVKATSL--NLLHDDAEMLGYRKQAGSAAQE-------GIVLISPMEIQAY 1045
 
Name Accession Description Interval E-value
Glyco_hydro_38C pfam07748
Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases are key enzymes of ...
240-456 3.04e-65

Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases are key enzymes of carbohydrate metabolism.


Pssm-ID: 400208 [Multi-domain]  Cd Length: 204  Bit Score: 213.27  E-value: 3.04e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168 240 IENEHIRATFDPDTGLLMEIMNMNQ--QLLLPVRQTFFWYNASIGDnesdqaSGAYIFRP-NQQKPLPVSRWAQIHLVKT 316
Cdd:pfam07748   1 LENGFLKVEFDNDTGTLTSIYDKELsrEVLAEVGNQFGLYEDIPGY------SDAWDFRPfYEAKPLEVDEQSIEVVEDG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168 317 PLVQEVHQNFSAW---CSQVVRLYPGQRHLELEWSVGPIpvgdtwGKEVISRFDTPLETKGRFYTDSNGREILERRRDYR 393
Cdd:pfam07748  75 PLVAEVHVKFKIGgseISQVIRLYKGSPRLEFETTVDWH------EREVLLKVAFPIDSQAEFATDENGFGVIKRPTHQN 148
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370475168 394 PTWKLNQTEPvagnyyPVNTRIYITDGNMQLTVLTDRSQGGSSLrDGSLELMVHRRLLKDDGR 456
Cdd:pfam07748 149 TSWDLARFEV------PIHSWVDLSDSNYGVSLLNDSKYGGSSL-DGQLELSLLRRPLYPDPR 204
PLN02701 PLN02701
alpha-mannosidase
9-633 2.15e-57

alpha-mannosidase


Pssm-ID: 178304 [Multi-domain]  Cd Length: 1050  Bit Score: 209.65  E-value: 2.15e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168    9 DFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVG-----PYGSGDSAPL-NEAMAVLQHHDAV 82
Cdd:PLN02701   375 DFFTYADRQQDYWSGYYVSRPFFKAVDRVLEQTLRAAEILFSFLLGYCRRFqceklPTSFSYKLTAaRRNLALFQHHDGV 454
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168   83 SGTSRQHVANDYARQLAAGW--------GPCEVLLSNALARLRGFKDHFTFCQQ--------LNISICPLSQTAARfqVI 146
Cdd:PLN02701   455 TGTAKDHVVVDYGTRMHTSLqdlqifmsAAVEVLLGIRHEKSDQTPSWFEPEQSrskydmlpVHKVINLREGKAHR--VV 532
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  147 VYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVvifpsSDSQAHPPELLFS--------ASLPALGFSTYSVAQ--- 215
Cdd:PLN02701   533 FFNPLEQTREEVVMVVVDRPAVCVFDSNWTCVPSQI-----SPEWQHDGEKLFTgrhrlywkASVPALGLETYFIANgnv 607
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  216 -----VPRWKPQARAPQPIP-----RRSWSPALTIE--NEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYnasigd 283
Cdd:PLN02701   608 scekaVPAKLKVFNSDDKFPcpepySCSKLEGDTVEisNSHQTLGFDVKTGLLRKIKIHKNGSETVVGEEIGMY------ 681
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  284 neSDQASGAYIFRPN-QQKPLpVSRWAQIHLVKTPLVQEVH-QNFSAW----CSQVVRLYPGQRHL-----ELEWSVGPI 352
Cdd:PLN02701   682 --SSQGSGAYLFKPDgEAQPI-VQAGGLVVVSEGPLVQEVHsVPKTKWekspLSRSTRLYHGGKSVqdlsvEKEYHVELL 758
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  353 pvGDTWG-KEVISRFDTPLETKGRFYTDSNGREILeRRRDYRPTwklnqtePVAGNYYPVNTRIYITDGNMQ-LTVLTDR 430
Cdd:PLN02701   759 --GHDFNdKELIVRFKTDIDNKRVFYSDLNGFQMS-RRETYDKI-------PLQGNYYPMPSLAFLQGSNGQrFSVHSRQ 828
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  431 SQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVrgRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVlapggGA 510
Cdd:PLN02701   829 SLGVASLKNGWLEIMLDRRLVQDDGRGLGQGVMDNRPMNVV--FHLLLESNISSSPPASNPLPLQPSLLSHRV-----GA 901
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  511 AYN---------------LGAPPRTQFSGLRRDLPPSVHLLTLASWGP--EMVLLRLEHQFAV-----GEDS-----GRN 563
Cdd:PLN02701   902 HLNypmhaflakkpqatsVENPQDTSFAPLAKPLPCDLHIVNFKVPRPskYSQQEAEDPRFGLllqrrGWDSsycrkGGT 981
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370475168  564 LSAPVT---LNLRDLFSTFTITRLQETTLvaNQLREAASRLKWTTNTGPTPHQtpyqldpANITLEPMEIRTF 633
Cdd:PLN02701   982 QCTTLAnepVNLFDMFKDLAVSKVKATSL--NLLHDDAEMLGYRKQAGSAAQE-------GIVLISPMEIQAY 1045
Alpha-mann_mid pfam09261
Alpha mannosidase middle domain; Members of this family adopt a structure consisting of three ...
19-116 4.99e-30

Alpha mannosidase middle domain; Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase.


Pssm-ID: 462728 [Multi-domain]  Cd Length: 98  Bit Score: 113.51  E-value: 4.99e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  19 QFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQL 98
Cdd:pfam09261   1 EYHRGTYTSRADLKRLNRKLEHLLRAAEQLSSLAALSLLGYEYPKEELEELWKALLLNQFHDILPGSSIQEVYRDAEARL 80
                          90
                  ....*....|....*...
gi 1370475168  99 AAGWGPCEVLLSNALARL 116
Cdd:pfam09261  81 AEALKETEKLLEDALRLL 98
Alpha-mann_mid smart00872
Alpha mannosidase, middle domain; Members of this entry belong to the glycosyl hydrolase ...
20-98 7.96e-27

Alpha mannosidase, middle domain; Members of this entry belong to the glycosyl hydrolase family 38, This domain, which is found in the central region adopts a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase.


Pssm-ID: 214875 [Multi-domain]  Cd Length: 79  Bit Score: 103.79  E-value: 7.96e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370475168   20 FWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQL 98
Cdd:smart00872   1 YHRGTYTSRPYLKRLNRRAESLLRAAEELAALAALLSLGYKYPSEQLEELWKALLLNQHHDAITGTSIDEVYDDYEKRL 79
 
Name Accession Description Interval E-value
Glyco_hydro_38C pfam07748
Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases are key enzymes of ...
240-456 3.04e-65

Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases are key enzymes of carbohydrate metabolism.


Pssm-ID: 400208 [Multi-domain]  Cd Length: 204  Bit Score: 213.27  E-value: 3.04e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168 240 IENEHIRATFDPDTGLLMEIMNMNQ--QLLLPVRQTFFWYNASIGDnesdqaSGAYIFRP-NQQKPLPVSRWAQIHLVKT 316
Cdd:pfam07748   1 LENGFLKVEFDNDTGTLTSIYDKELsrEVLAEVGNQFGLYEDIPGY------SDAWDFRPfYEAKPLEVDEQSIEVVEDG 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168 317 PLVQEVHQNFSAW---CSQVVRLYPGQRHLELEWSVGPIpvgdtwGKEVISRFDTPLETKGRFYTDSNGREILERRRDYR 393
Cdd:pfam07748  75 PLVAEVHVKFKIGgseISQVIRLYKGSPRLEFETTVDWH------EREVLLKVAFPIDSQAEFATDENGFGVIKRPTHQN 148
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370475168 394 PTWKLNQTEPvagnyyPVNTRIYITDGNMQLTVLTDRSQGGSSLrDGSLELMVHRRLLKDDGR 456
Cdd:pfam07748 149 TSWDLARFEV------PIHSWVDLSDSNYGVSLLNDSKYGGSSL-DGQLELSLLRRPLYPDPR 204
PLN02701 PLN02701
alpha-mannosidase
9-633 2.15e-57

alpha-mannosidase


Pssm-ID: 178304 [Multi-domain]  Cd Length: 1050  Bit Score: 209.65  E-value: 2.15e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168    9 DFFPYADGPHQFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVG-----PYGSGDSAPL-NEAMAVLQHHDAV 82
Cdd:PLN02701   375 DFFTYADRQQDYWSGYYVSRPFFKAVDRVLEQTLRAAEILFSFLLGYCRRFqceklPTSFSYKLTAaRRNLALFQHHDGV 454
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168   83 SGTSRQHVANDYARQLAAGW--------GPCEVLLSNALARLRGFKDHFTFCQQ--------LNISICPLSQTAARfqVI 146
Cdd:PLN02701   455 TGTAKDHVVVDYGTRMHTSLqdlqifmsAAVEVLLGIRHEKSDQTPSWFEPEQSrskydmlpVHKVINLREGKAHR--VV 532
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  147 VYNPLGRKVNWMVRLPVSEGVFVVKDPNGRTVPSDVvifpsSDSQAHPPELLFS--------ASLPALGFSTYSVAQ--- 215
Cdd:PLN02701   533 FFNPLEQTREEVVMVVVDRPAVCVFDSNWTCVPSQI-----SPEWQHDGEKLFTgrhrlywkASVPALGLETYFIANgnv 607
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  216 -----VPRWKPQARAPQPIP-----RRSWSPALTIE--NEHIRATFDPDTGLLMEIMNMNQQLLLPVRQTFFWYnasigd 283
Cdd:PLN02701   608 scekaVPAKLKVFNSDDKFPcpepySCSKLEGDTVEisNSHQTLGFDVKTGLLRKIKIHKNGSETVVGEEIGMY------ 681
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  284 neSDQASGAYIFRPN-QQKPLpVSRWAQIHLVKTPLVQEVH-QNFSAW----CSQVVRLYPGQRHL-----ELEWSVGPI 352
Cdd:PLN02701   682 --SSQGSGAYLFKPDgEAQPI-VQAGGLVVVSEGPLVQEVHsVPKTKWekspLSRSTRLYHGGKSVqdlsvEKEYHVELL 758
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  353 pvGDTWG-KEVISRFDTPLETKGRFYTDSNGREILeRRRDYRPTwklnqtePVAGNYYPVNTRIYITDGNMQ-LTVLTDR 430
Cdd:PLN02701   759 --GHDFNdKELIVRFKTDIDNKRVFYSDLNGFQMS-RRETYDKI-------PLQGNYYPMPSLAFLQGSNGQrFSVHSRQ 828
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  431 SQGGSSLRDGSLELMVHRRLLKDDGRGVSEPLMENGSGAWVrgRHLVLLDTAQAAAAGHRLLAEQEVLAPQVVlapggGA 510
Cdd:PLN02701   829 SLGVASLKNGWLEIMLDRRLVQDDGRGLGQGVMDNRPMNVV--FHLLLESNISSSPPASNPLPLQPSLLSHRV-----GA 901
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  511 AYN---------------LGAPPRTQFSGLRRDLPPSVHLLTLASWGP--EMVLLRLEHQFAV-----GEDS-----GRN 563
Cdd:PLN02701   902 HLNypmhaflakkpqatsVENPQDTSFAPLAKPLPCDLHIVNFKVPRPskYSQQEAEDPRFGLllqrrGWDSsycrkGGT 981
                          650       660       670       680       690       700       710
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370475168  564 LSAPVT---LNLRDLFSTFTITRLQETTLvaNQLREAASRLKWTTNTGPTPHQtpyqldpANITLEPMEIRTF 633
Cdd:PLN02701   982 QCTTLAnepVNLFDMFKDLAVSKVKATSL--NLLHDDAEMLGYRKQAGSAAQE-------GIVLISPMEIQAY 1045
Alpha-mann_mid pfam09261
Alpha mannosidase middle domain; Members of this family adopt a structure consisting of three ...
19-116 4.99e-30

Alpha mannosidase middle domain; Members of this family adopt a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. They are predominantly found in the enzyme alpha-mannosidase.


Pssm-ID: 462728 [Multi-domain]  Cd Length: 98  Bit Score: 113.51  E-value: 4.99e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475168  19 QFWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQL 98
Cdd:pfam09261   1 EYHRGTYTSRADLKRLNRKLEHLLRAAEQLSSLAALSLLGYEYPKEELEELWKALLLNQFHDILPGSSIQEVYRDAEARL 80
                          90
                  ....*....|....*...
gi 1370475168  99 AAGWGPCEVLLSNALARL 116
Cdd:pfam09261  81 AEALKETEKLLEDALRLL 98
Alpha-mann_mid smart00872
Alpha mannosidase, middle domain; Members of this entry belong to the glycosyl hydrolase ...
20-98 7.96e-27

Alpha mannosidase, middle domain; Members of this entry belong to the glycosyl hydrolase family 38, This domain, which is found in the central region adopts a structure consisting of three alpha helices, in an immunoglobulin/albumin-binding domain-like fold. The domain is predominantly found in the enzyme alpha-mannosidase.


Pssm-ID: 214875 [Multi-domain]  Cd Length: 79  Bit Score: 103.79  E-value: 7.96e-27
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370475168   20 FWTGYFSSRPALKRYERLSYNFLQVCNQLEALVGLAANVGPYGSGDSAPLNEAMAVLQHHDAVSGTSRQHVANDYARQL 98
Cdd:smart00872   1 YHRGTYTSRPYLKRLNRRAESLLRAAEELAALAALLSLGYKYPSEQLEELWKALLLNQHHDAITGTSIDEVYDDYEKRL 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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