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Conserved domains on  [gi|1370473101|ref|XP_024306853|]
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lipoxygenase homology domain-containing protein 1 isoform X10 [Homo sapiens]

Protein Classification

phospholipase C( domain architecture ID 10205341)

phospholipase C catayzes the hydroysis of a phosphatidylcholine to form 1,2-diacyl-sn-glycerol and phosphocholine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1042-1160 8.21e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 192.00  E-value: 8.21e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1042 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGW 1120
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101 1121 LVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 1160
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 63-183 1.24e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.23  E-value: 1.24e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   63 TTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPG 142
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  143 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 183
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 348-468 1.28e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 1.28e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  348 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCAD 427
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  428 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 468
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 773-893 5.00e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 5.00e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  773 TSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 852
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  853 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 893
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 194-320 2.46e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.95  E-value: 2.46e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  194 VPYEITLYTSDVFAAGTDANIFIIIYGcDAVCTQQKYLCTNKREQKqfFERKSASRFIVELEDVGEiIEKIRIGHNNTGM 273
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1370473101  274 NPGWHCSHVDIRRLLPDkdgaETLTFPCDRWLATSEDDKKTIRELVP 320
Cdd:cd01756     77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 646-763 1.94e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


:

Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 1.94e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  646 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 723
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101  724 FLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAV 763
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 517-632 2.05e-11

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01752:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 62.29  E-value: 2.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIwLDYPrGKRGFSRGSVEEFYVAGL-DVGIIKKIELGHDGASPESCW 595
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHH-LRDP-EKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1370473101  596 -----LVEELclavPTQGTKYMLnCNCWLAKDRGDGITSRVF 632
Cdd:cd01752     81 ylsrvIVRDL----QTGKKWFFL-CNDWLSVEEGDGTVERTF 117
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 5-30 4.22e-07

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd01756:

Pssm-ID: 412108  Cd Length: 120  Bit Score: 49.86  E-value: 4.22e-07
                           10        20
                   ....*....|....*....|....*.
gi 1370473101    5 RYYFPCQRWLAVEEDDGQLSRELLPV 30
Cdd:cd01756     95 EYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT super family cl00011
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 906-1007 5.71e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


The actual alignment was detected with superfamily member cd00113:

Pssm-ID: 412108  Cd Length: 116  Bit Score: 43.48  E-value: 5.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  906 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLMENSSRqraFRKGTTDTFEFDSiyLGDIASLCVGHLAREDrfiPK 982
Cdd:cd00113      3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQIDL--KLDIGDITKVYLRRDG---SG 74

                           90       100
                   ....*....|....*....|....*
gi 1370473101  983 RELAWHVKTITITEMEYGNVYFFNC 1007
Cdd:cd00113     75 LSDGWYCESITVQALGTKKVYTFPV 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1042-1160 8.21e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 192.00  E-value: 8.21e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1042 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGW 1120
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101 1121 LVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 1160
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 63-183 1.24e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.23  E-value: 1.24e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   63 TTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPG 142
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  143 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 183
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 348-468 1.28e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 1.28e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  348 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCAD 427
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  428 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 468
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 773-893 5.00e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 5.00e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  773 TSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 852
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  853 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 893
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 194-320 2.46e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.95  E-value: 2.46e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  194 VPYEITLYTSDVFAAGTDANIFIIIYGcDAVCTQQKYLCTNKREQKqfFERKSASRFIVELEDVGEiIEKIRIGHNNTGM 273
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1370473101  274 NPGWHCSHVDIRRLLPDkdgaETLTFPCDRWLATSEDDKKTIRELVP 320
Cdd:cd01756     77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 646-763 1.94e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 1.94e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  646 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 723
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101  724 FLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAV 763
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 775-886 4.83e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 89.41  E-value: 4.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  775 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 854
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370473101  855 LSYVDVKDNSRDE-TFHFQCDCWLSKSEGDGQT 886
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKET 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 65-172 1.23e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 1.23e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   65 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKsskTNSDKFERDSIEIFTVET-LDLGDLWKVRLGHDNTGKAPGW 143
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEIT---LDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1370473101  144 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 172
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 350-465 2.94e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 84.41  E-value: 2.94e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  350 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFERGTADTFII-EAADLGVIYKIKLRHDNSKWCADW 428
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1370473101  429 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 465
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1044-1153 7.68e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.55  E-value: 7.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1044 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYCSGWLV 1122
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101 1123 EKVEVT-NTSTGVATIFNCGRWLDKKRGDGLT 1153
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
67-170 1.05e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 68.05  E-value: 1.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101    67 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRLGHDNtgKAPGWFV 145
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1370473101   146 DWVEVDAPSLGKCMTFPCGRWLAKN 170
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 648-757 2.58e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 2.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  648 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 726
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370473101  727 RILL-KNMNTGDLTMFYYGDWLSQ-RKGKKTLV 757
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGsKKYKETRV 113
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1043-1147 1.06e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.36  E-value: 1.06e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  1043 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGycSGWL 1121
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRH--PEWF 79

                            90       100
                    ....*....|....*....|....*.
gi 1370473101  1122 VEKVEVTNTSTGVATIFNCGRWLDKK 1147
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 196-314 1.82e-12

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 65.15  E-value: 1.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  196 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKReqkqfFERKSASRFIVELE-DVGEIIeKIRIGHNNTGMN 274
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101  275 PGWHCSHVdirRLLPDKDGAETLTFPCDRWLATSEDDKKT 314
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 517-632 2.05e-11

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 62.29  E-value: 2.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIwLDYPrGKRGFSRGSVEEFYVAGL-DVGIIKKIELGHDGASPESCW 595
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHH-LRDP-EKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1370473101  596 -----LVEELclavPTQGTKYMLnCNCWLAKDRGDGITSRVF 632
Cdd:cd01752     81 ylsrvIVRDL----QTGKKWFFL-CNDWLSVEEGDGTVERTF 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 517-632 1.17e-09

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 57.06  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKR-IWLDYPRgkrgFSRGSVEEFYV-AGLDVGIIKKIELGHDGASPESC 594
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLeITLDNPD----FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1370473101  595 WLVEELCLAVP-TQGTKYMLNCNCWLAKDRgDGITSRVF 632
Cdd:pfam01477   77 WFLKSITVEVPgETGGKYTFPCNSWVYGSK-KYKETRVF 114
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
775-879 5.83e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.57  E-value: 5.83e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   775 YTVAVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKgiFPGWH 854
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 1370473101   855 LSYVDVKDNSRDETFHFQCDCWLSK 879
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
350-455 9.49e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.18  E-value: 9.49e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   350 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFERGTADTFIIE-AADLGVIYKIKLRHDNSKwcADW 428
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 1370473101   429 YVEKVEIWNDTNEDEFLFLCGRWLSLK 455
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 5-30 4.22e-07

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 49.86  E-value: 4.22e-07
                           10        20
                   ....*....|....*....|....*.
gi 1370473101    5 RYYFPCQRWLAVEEDDGQLSRELLPV 30
Cdd:cd01756     95 EYTFPCNRWLDKDEDDGQIVRELYPS 120
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
517-622 5.24e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 5.24e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIwlDYPRGKRGFSRGSVEEFYVAG-LDVGIIKKIELGHDGASPEscW 595
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESK--LDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRHPE--W 78

                            90       100
                    ....*....|....*....|....*..
gi 1370473101   596 LVEELCLAVPTQGTKYMLNCNCWLAKD 622
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
648-748 1.75e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 44.94  E-value: 1.75e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   648 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGlgSRPEWFL 725
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 1370473101   726 ERILLKNMNTGDLTMFYYGDWLS 748
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 906-1007 5.71e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.48  E-value: 5.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  906 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLMENSSRqraFRKGTTDTFEFDSiyLGDIASLCVGHLAREDrfiPK 982
Cdd:cd00113      3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQIDL--KLDIGDITKVYLRRDG---SG 74

                           90       100
                   ....*....|....*....|....*
gi 1370473101  983 RELAWHVKTITITEMEYGNVYFFNC 1007
Cdd:cd00113     75 LSDGWYCESITVQALGTKKVYTFPV 99
 
Name Accession Description Interval E-value
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 1042-1160 8.21e-57

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 192.00  E-value: 8.21e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1042 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQK-MRNLFERGSTDRFFLETLELGELRKVRLEHDSSGYCSGW 1120
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101 1121 LVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLFPS 1160
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 63-183 1.24e-56

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 191.23  E-value: 1.24e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   63 TTFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSkTNSDKFERDSIEIFTVETLDLGDLWKVRLGHDNTGKAPG 142
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKS-NNKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  143 WFVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 183
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 348-468 1.28e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 185.45  E-value: 1.28e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  348 VLYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtNKFERGTADTFIIEAADLGVIYKIKLRHDNSKWCAD 427
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNK-NKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  428 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFYEK 468
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 773-893 5.00e-54

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 183.91  E-value: 5.00e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  773 TSYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNTDTFNFpDMLSLGHLCKLRVWHDNKGIFPG 852
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSNNKNKFERGQTDKFTV-EAVDLGKLKKIRIGHDNSGLGAG 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1370473101  853 WHLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 893
Cdd:cd01756     80 WFLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 194-320 2.46e-46

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 161.95  E-value: 2.46e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  194 VPYEITLYTSDVFAAGTDANIFIIIYGcDAVCTQQKYLCTNKREQKqfFERKSASRFIVELEDVGEiIEKIRIGHNNTGM 273
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYG-ENGDTGKRKLKKSNNKNK--FERGQTDKFTVEAVDLGK-LKKIRIGHDNSGL 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1370473101  274 NPGWHCSHVDIRRLLPDkdgaETLTFPCDRWLATSEDDKKTIRELVP 320
Cdd:cd01756     77 GAGWFLDKVEIREPGTG----DEYTFPCNRWLDKDEDDGQIVRELYP 119
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 646-763 1.94e-45

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 159.26  E-value: 1.94e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  646 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKK--KARFEREQNDTFIMEILDIAPFTKMRIRIDGLGSRPEW 723
Cdd:cd01756      1 VTYEVTVKTGDVKGAGTDANVFITLYGENGDTGKRKLKKSnnKNKFERGQTDKFTVEAVDLGKLKKIRIGHDNSGLGAGW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101  724 FLERILLKNMNTGDLTMFYYGDWLSQRKGKKTLVCEMCAV 763
Cdd:cd01756     81 FLDKVEIREPGTGDEYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 648-758 5.52e-31

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 117.83  E-value: 5.52e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  648 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 726
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILDGPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGWYCE 82

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101  727 RILLKNMNTGDLTMFYYGDWLSQRKGKKTLVC 758
Cdd:cd00113     83 SITVQALGTKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 774-893 5.71e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 112.37  E-value: 5.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  774 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGW 853
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDP-EKPIFERGSVDSFLLTTPFPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101  854 HLSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVRDFACA 893
Cdd:cd01752     81 YLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 349-466 8.49e-29

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 111.98  E-value: 8.49e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  349 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRTnkFERGTADTFIIEAA-DLGVIYKIKLRHDNSKWCAD 427
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPS 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1370473101  428 WYVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLFY 466
Cdd:cd01752     80 WYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 1043-1158 8.64e-28

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 108.90  E-value: 8.64e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1043 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLETLE-LGELRKVRLEHDSSGYCSGWL 1121
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPIFERGSVDSFLLTTPFpLGELQSIRLWHDNSGLSPSWY 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1370473101 1122 VEKVEVTNTSTGVATIFNCGRWLDKKRGDGLTWRDLF 1158
Cdd:cd01752     82 LSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 67-183 1.62e-23

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 96.58  E-value: 1.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   67 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSdkFERDSIEIFTVETL-DLGDLWKVRLGHDNTGKAPGWFV 145
Cdd:cd01752      5 VTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLRDPEKPI--FERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSWYL 82

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1370473101  146 DWVEVDAPSLGKCMTFPCGRWLAKNEDDGSIIRDLFHA 183
Cdd:cd01752     83 SRVIVRDLQTGKKWFFLCNDWLSVEEGDGTVERTFPVA 120
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 65-175 2.44e-21

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 90.48  E-value: 2.44e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   65 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSsktNSDKFERDSIEIFTVET-LDLGDLWKVRLGHDNTGKAPGW 143
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDIPILD---GPGSFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDGW 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101  144 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDGS 175
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTS 111
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 775-886 4.83e-21

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 89.41  E-value: 4.83e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  775 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQsaNWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 854
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITL--DNPDFERGAEDSFEIDTDWDVGAILKINLHWDNNGLSDEWF 78

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370473101  855 LSYVDVKDNSRDE-TFHFQCDCWLSKSEGDGQT 886
Cdd:pfam01477   79 LKSITVEVPGETGgKYTFPCNSWVYGSKKYKET 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 775-888 7.37e-20

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 86.24  E-value: 7.37e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  775 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLalKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPGWH 854
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSDI--PILDGPGSFERGSTDTFQIDLKLDIGDITKVYLRRDGSGLSDGWY 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1370473101  855 LSYVDVKDNSRDETFHFQCDCWLSKSEGDGQTVR 888
Cdd:cd00113     81 CESITVQALGTKKVYTFPVNRWVLGGKWYTSVRS 114
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 65-172 1.23e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 85.56  E-value: 1.23e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   65 FSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKsskTNSDKFERDSIEIFTVET-LDLGDLWKVRLGHDNTGKAPGW 143
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEIT---LDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1370473101  144 FVDWVEVDAPSL-GKCMTFPCGRWLAKNED 172
Cdd:pfam01477   78 FLKSITVEVPGEtGGKYTFPCNSWVYGSKK 107
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 350-465 2.94e-19

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 84.41  E-value: 2.94e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  350 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENRtnkFERGTADTFII-EAADLGVIYKIKLRHDNSKWCADW 428
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD---FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDEW 77

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1370473101  429 YVEKVEIW-NDTNEDEFLFLCGRWLSlKKEDGRLERLF 465
Cdd:pfam01477   78 FLKSITVEvPGETGGKYTFPCNSWVY-GSKKYKETRVF 114
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 1043-1153 9.66e-19

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 83.16  E-value: 9.66e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1043 KYEVIVTTGYEPGAGTDANVFVTIFGANGdtgKRELKQKMRNL--FERGSTDRFFLET-LELGELRKVRLEHDSSGYCSG 1119
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYGENG---NSSDIPILDGPgsFERGSTDTFQIDLkLDIGDITKVYLRRDGSGLSDG 78

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1370473101 1120 WLVEKVEVTNTSTGVATIFNCGRWLDKKRGDGLT 1153
Cdd:cd00113     79 WYCESITVQALGTKKVYTFPVNRWVLGGKWYTSV 112
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 196-318 2.87e-18

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 81.94  E-value: 2.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  196 YEITLYTSDVFAAGTDANIFIIIYGCDAvcTQQKYLCTNkrEQKQFFERKSASRFIVE-LEDVGEIiEKIRIGHNNTGMN 274
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEG--ESEPHHLRD--PEKPIFERGSVDSFLLTtPFPLGEL-QSIRLWHDNSGLS 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1370473101  275 PGWHCSHVDIRRLLPDKdgaeTLTFPCDRWLATSEDDKKTIREL 318
Cdd:cd01752     78 PSWYLSRVIVRDLQTGK----KWFFLCNDWLSVEEGDGTVERTF 117
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 1044-1153 7.68e-18

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 80.55  E-value: 7.68e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1044 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGYCSGWLV 1122
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLD-NPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFL 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101 1123 EKVEVT-NTSTGVATIFNCGRWLDKKRGDGLT 1153
Cdd:pfam01477   80 KSITVEvPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 350-465 7.56e-16

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 74.68  E-value: 7.56e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  350 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGErylGKSENRTNKFERGTADTFIIEAA-DLGVIYKIKLRHDNSKWCADW 428
Cdd:cd00113      3 YTVTIKTGDKKGAGTDSNISLALYGENGNSSD---IPILDGPGSFERGSTDTFQIDLKlDIGDITKVYLRRDGSGLSDGW 79

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1370473101  429 YVEKVEIWNDTNEDEFLFLCGRWLSLKKEDGRLERLF 465
Cdd:cd00113     80 YCESITVQALGTKKVYTFPVNRWVLGGKWYTSVRSLK 116
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 647-756 3.02e-15

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 73.08  E-value: 3.02e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  647 LYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQL-DKKKARFEREQNDTFIMEildiAPF-----TKMRIRIDGLGSR 720
Cdd:cd01752      2 LYLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHHLrDPEKPIFERGSVDSFLLT----TPFplgelQSIRLWHDNSGLS 77

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370473101  721 PEWFLERILLKNMNTGDLTMFYYGDWLSQRKGKKTL 756
Cdd:cd01752     78 PSWYLSRVIVRDLQTGKKWFFLCNDWLSVEEGDGTV 113
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 65-174 8.41e-15

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 71.80  E-value: 8.41e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   65 FSVTIKTGVK-KNAGTDANVFITLFGTQDDTGMTLLKssktnsdkfeRDSIEiFTVETLDLGDLWKVRLGHDNTGKAPGW 143
Cdd:cd01757      3 YHVVIVPSKKlGGSMFTANPWICVSGELGETPPLQIP----------KNSLE-MTFDCQNLGKLTTVQIGHDNSGLLAKW 71

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1370473101  144 FVDWVEVDAPSLGKCMTFPCGRWLAKNEDDG 174
Cdd:cd01757     72 LVEYVMVRNEITGHTYKFPCGRWLGEGVDDG 102
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
67-170 1.05e-13

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 68.05  E-value: 1.05e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101    67 VTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNSdkFERDSIEIFTVET-LDLGDLWKVRLGHDNtgKAPGWFV 145
Cdd:smart00308    5 VTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGI--FARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|....*
gi 1370473101   146 DWVEVDAPSLGKCMTFPCGRWLAKN 170
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 648-757 2.58e-13

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 67.46  E-value: 2.58e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  648 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWFLE 726
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPDFERGAEDSFEIDTdWDVGAILKINLHWDNNGLSDEWFLK 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370473101  727 RILL-KNMNTGDLTMFYYGDWLSQ-RKGKKTLV 757
Cdd:pfam01477   81 SITVeVPGETGGKYTFPCNSWVYGsKKYKETRV 113
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
1043-1147 1.06e-12

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 65.36  E-value: 1.06e-12
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  1043 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNLFERGSTDRFFLET-LELGELRKVRLEHDSSGycSGWL 1121
Cdd:smart00308    2 KYKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRH--PEWF 79

                            90       100
                    ....*....|....*....|....*.
gi 1370473101  1122 VEKVEVTNTSTGVATIFNCGRWLDKK 1147
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 1046-1153 1.51e-12

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 65.25  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1046 VIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKqkmRNLFErgstdrFFLETLELGELRKVRLEHDSSGYCSGWLVEKV 1125
Cdd:cd01757      6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIP---KNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWLVEYV 76

                           90       100
                   ....*....|....*....|....*...
gi 1370473101 1126 EVTNTSTGVATIFNCGRWLDKKRGDGLT 1153
Cdd:cd01757     77 MVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 196-314 1.82e-12

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 65.15  E-value: 1.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  196 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKReqkqfFERKSASRFIVELE-DVGEIIeKIRIGHNNTGMN 274
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLEITLDNPD-----FERGAEDSFEIDTDwDVGAIL-KINLHWDNNGLS 74

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1370473101  275 PGWHCSHVdirRLLPDKDGAETLTFPCDRWLATSEDDKKT 314
Cdd:pfam01477   75 DEWFLKSI---TVEVPGETGGKYTFPCNSWVYGSKKYKET 111
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 775-881 7.53e-12

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 63.71  E-value: 7.53e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  775 YTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQS------ANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKG 848
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwgglmgAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1370473101  849 IFPGWHLSYVDVK---DNSRDETFHFQCDCWLSKSE 881
Cdd:cd01754     83 NHPGWYVNYVEVTqagQHAPCMQHLFAVEQWLATDE 118
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 195-305 1.28e-11

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 62.74  E-value: 1.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  195 PYEITLYTSDVFAAGTDANIFIIIYGcdAVCTQQKYLCTNKreqKQFFERKSASRFIVELE-DVGeIIEKIRIGHNNTGM 273
Cdd:cd00113      2 RYTVTIKTGDKKGAGTDSNISLALYG--ENGNSSDIPILDG---PGSFERGSTDTFQIDLKlDIG-DITKVYLRRDGSGL 75

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101  274 NPGWHCSHVDIRRLlpdkDGAETLTFPCDRWL 305
Cdd:cd00113     76 SDGWYCESITVQAL----GTKKVYTFPVNRWV 103
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 517-632 2.05e-11

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 62.29  E-value: 2.05e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIwLDYPrGKRGFSRGSVEEFYVAGL-DVGIIKKIELGHDGASPESCW 595
Cdd:cd01752      3 YLVTVFTGWRRGAGTTAKVTITLYGAEGESEPHH-LRDP-EKPIFERGSVDSFLLTTPfPLGELQSIRLWHDNSGLSPSW 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1370473101  596 -----LVEELclavPTQGTKYMLnCNCWLAKDRGDGITSRVF 632
Cdd:cd01752     81 ylsrvIVRDL----QTGKKWFFL-CNDWLSVEEGDGTVERTF 117
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 64-177 3.36e-11

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 61.17  E-value: 3.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   64 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSKTNsdkFERDSIEIFTVE-TLDLGDLWKVRLGHDNTGKAPG 142
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD---FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDA 78

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1370473101  143 WFVDWVEVDAPSlGKCMTFPCGRWLaknEDDGSII 177
Cdd:cd01753     79 WFCNYITVTGPG-GDEYHFPCYRWI---EGYGTLE 109
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 64-171 2.41e-10

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 59.48  E-value: 2.41e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   64 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTG-MTLLKS----SKTNSDKFERDSIEIFTVETLDL-GDLWKVRLGHDNT 137
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrIANLEAwgglMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1370473101  138 GKAPGWFVDWVEVDAPSLGK-CMT--FPCGRWLAKNE 171
Cdd:cd01754     82 GNHPGWYVNYVEVTQAGQHApCMQhlFAVEQWLATDE 118
PLAT pfam01477
PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. ...
 517-632 1.17e-09

PLAT/LH2 domain; This domain is found in a variety of membrane or lipid associated proteins. It is called the PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology) domain. The known structure of pancreatic lipase shows this domain binds to procolipase pfam01114, which mediates membrane association. So it appears possible that this domain mediates membrane attachment via other protein binding partners. The structure of this domain is known for many members of the family and is composed of a beta sandwich.


Pssm-ID: 396180  Cd Length: 115  Bit Score: 57.06  E-value: 1.17e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKR-IWLDYPRgkrgFSRGSVEEFYV-AGLDVGIIKKIELGHDGASPESC 594
Cdd:pfam01477    1 YQVKVVTGDELGAGTDADVYISLYGKVGESAQLeITLDNPD----FERGAEDSFEIdTDWDVGAILKINLHWDNNGLSDE 76

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1370473101  595 WLVEELCLAVP-TQGTKYMLNCNCWLAKDRgDGITSRVF 632
Cdd:pfam01477   77 WFLKSITVEVPgETGGKYTFPCNSWVYGSK-KYKETRVF 114
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 1042-1151 2.30e-09

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 56.16  E-value: 2.30e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1042 VKYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKMRNlFERGSTDRFFLE-TLELGELRKVRLEHDSSGYCSGW 1120
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-FERGAVDEYKVKvPEDLGELLLVRLRKRKYLLFDAW 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1370473101 1121 LVEKVEVTNTSTGVATiFNCGRWLDkkrGDG 1151
Cdd:cd01753     80 FCNYITVTGPGGDEYH-FPCYRWIE---GYG 106
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 348-464 2.33e-09

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 56.01  E-value: 2.33e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  348 VLYSVQIFTGN-IPGAGTDAKVYITIYGDLGDTGERYLGKsenrtNKFErgtadtFIIEAADLGVIYKIKLRHDNSKWCA 426
Cdd:cd01757      1 MPYHVVIVPSKkLGGSMFTANPWICVSGELGETPPLQIPK-----NSLE------MTFDCQNLGKLTTVQIGHDNSGLLA 69

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1370473101  427 DWYVEKVEIWNDTNEDEFLFLCGRWLS-----LKKEDGRLERL 464
Cdd:cd01757     70 KWLVEYVMVRNEITGHTYKFPCGRWLGegvddGNGEDGSLERV 112
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
775-879 5.83e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.57  E-value: 5.83e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   775 YTVAVKTSDILGAGTDANVFIIIFGENGDSGtLALKQSANWNKFERNNTDTFNFPDMLSLGHLCKLRVWHDNKgiFPGWH 854
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGK-ESKLDYLFKGIFARGSTYEFTFDVDEDFGELGAVKIKNEHR--HPEWF 79

                            90       100
                    ....*....|....*....|....*
gi 1370473101   855 LSYVDVKDNSRDETFHFQCDCWLSK 879
Cdd:smart00308   80 LKSITVKDLPTGGKYHFPCNSWVYP 104
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
350-455 9.49e-09

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 54.18  E-value: 9.49e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   350 YSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLGKSENrtNKFERGTADTFIIE-AADLGVIYKIKLRHDNSKwcADW 428
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYLFK--GIFARGSTYEFTFDvDEDFGELGAVKIKNEHRH--PEW 78

                            90       100
                    ....*....|....*....|....*..
gi 1370473101   429 YVEKVEIWNDTNEDEFLFLCGRWLSLK 455
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 1044-1144 3.83e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 53.31  E-value: 3.83e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1044 YEVIVTTGYEPGAGTDANVFVTIFGANGDTGK-------RELKQKMRNLFERGSTDRFFLETLEL-GELRKVRLEHDSSG 1115
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRianleawGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGTG 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1370473101 1116 YCSGWLVEKVEVtnTSTGVAT-----IFNCGRWL 1144
Cdd:cd01754     83 NHPGWYVNYVEV--TQAGQHApcmqhLFAVEQWL 114
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 349-435 4.97e-08

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 52.93  E-value: 4.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  349 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTG-----ERYLGKSENRTNKFERGTADTFIIEAADL-GVIYKIKLRHDNS 422
Cdd:cd01754      2 VYTIYVQTGSIWKAGTDSRISLQIYDADGPGLrianlEAWGGLMGAGHDYFERGNLDRFSGRGPCLpSPPCWMNLTSDGT 81

                           90
                   ....*....|...
gi 1370473101  423 KWCADWYVEKVEI 435
Cdd:cd01754     82 GNHPGWYVNYVEV 94
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 777-886 7.02e-08

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 51.77  E-value: 7.02e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  777 VAVKTSDILGAGTDANVFIIIFGENGDSGTLALKQSANWNKFERNNtdtfnfpdmlsLGHLCKLRVWHDNKGIFPGWHLS 856
Cdd:cd01757      6 VIVPSKKLGGSMFTANPWICVSGELGETPPLQIPKNSLEMTFDCQN-----------LGKLTTVQIGHDNSGLLAKWLVE 74

                           90       100       110
                   ....*....|....*....|....*....|
gi 1370473101  857 YVDVKDNSRDETFHFQCDCWLSKSEGDGQT 886
Cdd:cd01757     75 YVMVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT_repeat cd01756
PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 ...
 5-30 4.22e-07

PLAT/LH2 domain repeats of family of proteins with unknown function. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238854  Cd Length: 120  Bit Score: 49.86  E-value: 4.22e-07
                           10        20
                   ....*....|....*....|....*.
gi 1370473101    5 RYYFPCQRWLAVEEDDGQLSRELLPV 30
Cdd:cd01756     95 EYTFPCNRWLDKDEDDGQIVRELYPS 120
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 348-453 4.23e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 49.61  E-value: 4.23e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  348 VLYSVQIFTGNIPGAGTDAKVYITIygdLGDTGERYLGKSENRTNKFERGTADTFIIEA-ADLGVIYKIKLRHDNSKWCA 426
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTL---VGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFD 77

                           90       100
                   ....*....|....*....|....*..
gi 1370473101  427 DWYVEKVEIwNDTNEDEFLFLCGRWLS 453
Cdd:cd01753     78 AWFCNYITV-TGPGGDEYHFPCYRWIE 103
PLAT_plant_stress cd01754
PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of ...
 196-309 8.35e-07

PLAT/LH2 domain of plant-specific single domain protein family with unknown function. Many of its members are stress induced. In general, PLAT/LH2 consists of an eight stranded beta-barrel and it's proposed function is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238852  Cd Length: 129  Bit Score: 49.46  E-value: 8.35e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  196 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCT---NKREQKQFFERKSASRFIVELEDVGEIIEKIRIGHNNTG 272
Cdd:cd01754      3 YTIYVQTGSIWKAGTDSRISLQIYDADGPGLRIANLEAwggLMGAGHDYFERGNLDRFSGRGPCLPSPPCWMNLTSDGTG 82

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1370473101  273 MNPGWHCSHVDIRRLLPDKDGAETLtFPCDRWLATSE 309
Cdd:cd01754     83 NHPGWYVNYVEVTQAGQHAPCMQHL-FAVEQWLATDE 118
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 774-884 8.67e-07

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 48.84  E-value: 8.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  774 SYTVAVKTSDILGAGTDANVFIIIFGENGDSGTLALKqsaNWNK-FERNNTDTFNFPDMLSLGHLCKLRVWHDNKGIFPG 852
Cdd:cd01753      2 EYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLD---RPGYdFERGAVDEYKVKVPEDLGELLLVRLRKRKYLLFDA 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101  853 WHLSYVDVKDNSRDEtFHFQCDCWLsksEGDG 884
Cdd:cd01753     79 WFCNYITVTGPGGDE-YHFPCYRWI---EGYG 106
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 196-316 3.94e-06

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 46.92  E-value: 3.94e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  196 YEITLYTSDVFAAGTDANIFIIIYGCDAVCTQQKYLCTNKReqkqfFERKSASRFIVEL-EDVGEIIeKIRIGHNNTGMN 274
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYD-----FERGAVDEYKVKVpEDLGELL-LVRLRKRKYLLF 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1370473101  275 PGWHCSHVDIRRLlpdkdGAETLTFPCDRWLatseDDKKTIR 316
Cdd:cd01753     77 DAWFCNYITVTGP-----GGDEYHFPCYRWI----EGYGTLE 109
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
517-622 5.24e-06

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 46.10  E-value: 5.24e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIwlDYPRGKRGFSRGSVEEFYVAG-LDVGIIKKIELGHDGASPEscW 595
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESK--LDYLFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEHRHPE--W 78

                            90       100
                    ....*....|....*....|....*..
gi 1370473101   596 LVEELCLAVPTQGTKYMLNCNCWLAKD 622
Cdd:smart00308   79 FLKSITVKDLPTGGKYHFPCNSWVYPD 105
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 349-452 9.12e-06

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 45.92  E-value: 9.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  349 LYSVQIFTGNIPGAGTDAKVYITIYGDLGDTGERYLgksenrTNKFERGTADTFIIEAADLGVIYKIKLRhdNSKWCADW 428
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                           90       100
                   ....*....|....*....|....
gi 1370473101  429 YVEKVEIWNDTNEdEFLFLCGRWL 452
Cdd:cd02899     74 YCDYVRIKSEDGK-VFAFNVKRWI 96
LH2 smart00308
Lipoxygenase homology 2 (beta barrel) domain;
648-748 1.75e-05

Lipoxygenase homology 2 (beta barrel) domain;


Pssm-ID: 214608 [Multi-domain]  Cd Length: 105  Bit Score: 44.94  E-value: 1.75e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   648 YEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDK-KKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGlgSRPEWFL 725
Cdd:smart00308    3 YKVTVTTGGLDFAGTTASVSLSLVGAEGDGKESKLDYlFKGIFARGSTYEFTFDVdEDFGELGAVKIKNEH--RHPEWFL 80

                            90       100
                    ....*....|....*....|...
gi 1370473101   726 ERILLKNMNTGDLTMFYYGDWLS 748
Cdd:smart00308   81 KSITVKDLPTGGKYHFPCNSWVY 103
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 1043-1146 4.75e-05

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 43.61  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101 1043 KYEVIVTTGYEPGAGTDANVFVTIFGANGDTGKRELKQKmrnlFERGSTDRFFLETLELGELRKVRLEHDSSGycSGWLV 1122
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG----FYPGSLKRIRFRAADVGDINAIILSNTALN--DPWYC 75

                           90       100
                   ....*....|....*....|....
gi 1370473101 1123 EKVEVtNTSTGVATIFNCGRWLDK 1146
Cdd:cd02899     76 DYVRI-KSEDGKVFAFNVKRWIGY 98
PLAT cd00113
PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. ...
 906-1007 5.71e-05

PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates.


Pssm-ID: 238061  Cd Length: 116  Bit Score: 43.48  E-value: 5.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  906 YEIVIETGN--GGETRENVWLILEGR-KNRSKEFLMENSSRqraFRKGTTDTFEFDSiyLGDIASLCVGHLAREDrfiPK 982
Cdd:cd00113      3 YTVTIKTGDkkGAGTDSNISLALYGEnGNSSDIPILDGPGS---FERGSTDTFQIDL--KLDIGDITKVYLRRDG---SG 74

                           90       100
                   ....*....|....*....|....*
gi 1370473101  983 RELAWHVKTITITEMEYGNVYFFNC 1007
Cdd:cd00113     75 LSDGWYCESITVQALGTKKVYTFPV 99
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 646-757 6.13e-05

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 43.45  E-value: 6.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  646 VLYEMTVWTGDVVGGGTDSNIFMTLYGINGSTEEMQLDKKKARFEREQNDTFIMEI-LDIAPFTKMRIRIDGLGSRPEWF 724
Cdd:cd01753      1 AEYKVTVATGSSLFAGTDDYIYLTLVGTAGESEKQLLDRPGYDFERGAVDEYKVKVpEDLGELLLVRLRKRKYLLFDAWF 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1370473101  725 LERILLKNMNtGDLTMFYYGDWLSqrkGKKTLV 757
Cdd:cd01753     81 CNYITVTGPG-GDEYHFPCYRWIE---GYGTLE 109
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 5-28 7.74e-05

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 43.42  E-value: 7.74e-05
                           10        20
                   ....*....|....*....|....
gi 1370473101    5 RYYFPCQRWLAVEEDDGQLSRELL 28
Cdd:cd01752     95 KWFFLCNDWLSVEEGDGTVERTFP 118
PLAT_polycystin cd01752
PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane ...
 906-1009 1.02e-04

PLAT/LH2 domain of polycystin-1 like proteins. Polycystins are a large family of membrane proteins composed of multiple domains, present in fish, invertebrates, mammals, and humans that are widely expressed in various cell types and whose biological functions remain poorly defined. In human, mutations in polycystin-1 (PKD1) and polycystin-2 (PKD2) have been shown to be the cause for autosomal dominant polycystic kidney disease (ADPKD). The generally proposed function of PLAT/LH2 domains is to mediate interaction with lipids or membrane bound proteins.


Pssm-ID: 238850  Cd Length: 120  Bit Score: 43.03  E-value: 1.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  906 YEIVIETG--NGGETRENVWLILEGRKNRSKEFLMENSSRQrAFRKGTTDTF----EFDsiyLGDIASLCVGHLAREDRf 979
Cdd:cd01752      3 YLVTVFTGwrRGAGTTAKVTITLYGAEGESEPHHLRDPEKP-IFERGSVDSFllttPFP---LGELQSIRLWHDNSGLS- 77

                           90       100       110
                   ....*....|....*....|....*....|
gi 1370473101  980 iPkrelAWHVKTITITEMEYGNVYFFNCDC 1009
Cdd:cd01752     78 -P----SWYLSRVIVRDLQTGKKWFFLCND 102
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 196-307 5.76e-04

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 40.52  E-value: 5.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  196 YEITLYTSDVFAAGTDANIFIIIYGCDAVctqqkylcTNKREQKQFFERKSASRFIVELEDVGEIIEKIRIghnNTGMNP 275
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGSSGR--------SNPKTLSQGFYPGSLKRIRFRAADVGDINAIILS---NTALND 71

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1370473101  276 GWHCSHVDIRrllpdKDGAETLTFPCDRWLAT 307
Cdd:cd02899     72 PWYCDYVRIK-----SEDGKVFAFNVKRWIGY 98
PLAT_LOX cd01753
PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they ...
 517-619 1.47e-03

PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and plasma lipoproteins. Both types of enzymes are cytosolic but need this domain to access their sequestered membrane or micelle bound substrates.


Pssm-ID: 238851  Cd Length: 113  Bit Score: 39.60  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDErSKRIWLDYPrgKRGFSRGSVEEFYV-AGLDVGIIKKIELGHDGASPESCW 595
Cdd:cd01753      3 YKVTVATGSSLFAGTDDYIYLTLVGTAGE-SEKQLLDRP--GYDFERGAVDEYKVkVPEDLGELLLVRLRKRKYLLFDAW 79

                           90       100
                   ....*....|....*....|....
gi 1370473101  596 LVEELCLAVPtQGTKYMLNCNCWL 619
Cdd:cd01753     80 FCNYITVTGP-GGDEYHFPCYRWI 102
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 64-169 1.64e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 39.37  E-value: 1.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101   64 TFSVTIKTGVKKNAGTDANVFITLFGTQDDTGMTLLKSSktnsdkFERDSIEIFTVETLDLGDLWKVRLGhdNTGKAPGW 143
Cdd:cd02899      2 TYTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTLSQG------FYPGSLKRIRFRAADVGDINAIILS--NTALNDPW 73

                           90       100
                   ....*....|....*....|....*.
gi 1370473101  144 FVDWVEVDAPSlGKCMTFPCGRWLAK 169
Cdd:cd02899     74 YCDYVRIKSED-GKVFAFNVKRWIGY 98
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 515-628 2.52e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 39.06  E-value: 2.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  515 IPYYVSVTTGKHKDAA-TDSRAFIFLIGEDDErSKRIWLdyPRGkrgfsrgsVEEFYVAGLDVGIIKKIELGHDGASPES 593
Cdd:cd01757      1 MPYHVVIVPSKKLGGSmFTANPWICVSGELGE-TPPLQI--PKN--------SLEMTFDCQNLGKLTTVQIGHDNSGLLA 69

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1370473101  594 CWLVEELCLAVPTQGTKYMLNCNCWLAKDRGDGIT 628
Cdd:cd01757     70 KWLVEYVMVRNEITGHTYKFPCGRWLGEGVDDGNG 104
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 194-311 5.79e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 37.90  E-value: 5.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  194 VPYEITLYTSD-VFAAGTDANIFIIIYGcdavctqqkYLCTNKREQkqfFERKSASrFIVELEDVGeIIEKIRIGHNNTG 272
Cdd:cd01757      1 MPYHVVIVPSKkLGGSMFTANPWICVSG---------ELGETPPLQ---IPKNSLE-MTFDCQNLG-KLTTVQIGHDNSG 66

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1370473101  273 MNPGWHCSHVDIRRLLPDKdgaeTLTFPCDRWLATSEDD 311
Cdd:cd01757     67 LLAKWLVEYVMVRNEITGH----TYKFPCGRWLGEGVDD 101
PLAT_RAB6IP1 cd01757
PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains ...
 646-747 7.37e-03

PLAT/LH2 domain present in RAB6 interacting protein 1 (Rab6IP1)_like family. PLAT/LH2 domains consists of an eight stranded beta-barrel. In RabIP1 this domain may participate in lipid-mediated modulation of Rab6IP1's function via it's generally proposed function of mediating interaction with lipids or membrane bound proteins.


Pssm-ID: 238855  Cd Length: 114  Bit Score: 37.52  E-value: 7.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473101  646 VLYEMTVWTGDVVGG-GTDSNIFMTLYGINGSTEEMQLdkKKARFEreqndtFIMEILDIAPFTKMRIRIDGLGSRPEWF 724
Cdd:cd01757      1 MPYHVVIVPSKKLGGsMFTANPWICVSGELGETPPLQI--PKNSLE------MTFDCQNLGKLTTVQIGHDNSGLLAKWL 72

                           90       100
                   ....*....|....*....|...
gi 1370473101  725 LERILLKNMNTGDLTMFYYGDWL 747
Cdd:cd01757     73 VEYVMVRNEITGHTYKFPCGRWL 95
PLAT_SR cd02899
Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) ...
 517-587 9.31e-03

Scavenger receptor protein. A subfamily of PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and polycystin, but also as a single domain or as repeats.The putative function of this domain is to facilitate access to sequestered membrane or micelle bound substrates. This subfamily contains Toxoplasma gondii Scavenger protein TgSR1.


Pssm-ID: 239228  Cd Length: 109  Bit Score: 37.06  E-value: 9.31e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370473101  517 YYVSVTTGKHKDAATDSRAFIFLIGEDDERSKRIWldyprgKRGFSRGSVEEFYVAGLDVGIIKKIELGHD 587
Cdd:cd02899      3 YTASVQTGKDKEAGTNGTIEITLLGSSGRSNPKTL------SQGFYPGSLKRIRFRAADVGDINAIILSNT 67
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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