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Conserved domains on  [gi|1304918983|ref|XP_023114227|]
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LOW QUALITY PROTEIN: zinc finger MYM-type protein 1 [Felis catus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
530-763 5.15e-30

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 119.64  E-value: 5.15e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  530 SLAAQGISNWKK--TLEKFRKHEKSEMH----LKSLQFWRESQFCDEAVndnlsIHSKQMEGNKK--YLKLIIENILFLG 601
Cdd:pfam14291    2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  602 KQSLSLRGNDQSISTVNKGNFLELLEIRAKdKGEEVFRLLN--SQVDFYNSTQIQNDIIEIIKTEILQDIVNEINVSPaF 679
Cdd:pfam14291   77 HQGLPLRGHDESEESTNKGLFVELLKYTAG-QDEVVKKVLKnaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEMDNDV-F 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  680 SIICDETTDSATKEQLSICVRYPQKMSKavlIKERFLGFIDVEEMTGTNLHRTIKTYLQQIGVDLSKICGQAYDSTMNLR 759
Cdd:pfam14291  155 GILVDETADASDKEQMAIVFRYVDKYGV---PIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMS 231


                   ....
gi 1304918983  760 GKFN 763
Cdd:pfam14291  232 GEFN 235
Dimer_Tnp_hAT super family cl05324
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 1096-1153 1.40e-11

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


The actual alignment was detected with superfamily member pfam05699:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 61.51  E-value: 1.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1304918983 1096 HNNIPCISKLLYIALSWPVTS-SAENSFSTLprLKTYLCHTMGQEKLSGLALMAIEQEL 1153
Cdd:pfam05699   27 SSRYPNLSKLARDILSIPVSSaASERSFSTL--GKVILESRNRLEPLNVEALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 166-205 7.82e-09

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 52.37  E-value: 7.82e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1304918983  166 LPKKTCSNCSKDILNLKDVISVQLDDSSKNFCSQSCLSSY 205
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF super family cl02692
zinc finger in transposases and transcription factors;
487-567 4.92e-06

zinc finger in transposases and transcription factors;


The actual alignment was detected with superfamily member smart00597:

Pssm-ID: 214739  Cd Length: 91  Bit Score: 45.94  E-value: 4.92e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983   487 KSRSIKKSWCSNFQH-LKSSIKKDVTFCYSCQLFCQKNfscGGES--LAAQGISNWKKTLEKFRKHEKSEMH---LKSLQ 560
Cdd:smart00597    1 KPRRFQKSWFHQFPDwLEYSVEKDAAFCKYCYLFRPGR---DGGSdlFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVN 77


                    ....*..
gi 1304918983   561 FWRESQF 567
Cdd:smart00597   78 LMEQRQS 84
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 120-157 1.52e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


:

Pssm-ID: 428958  Cd Length: 40  Bit Score: 37.35  E-value: 1.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1304918983  120 AIQVSCSGCKKILQKGQTAY--QRKGSTQLFCSTFCITEY 157
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
530-763 5.15e-30

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 119.64  E-value: 5.15e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  530 SLAAQGISNWKK--TLEKFRKHEKSEMH----LKSLQFWRESQFCDEAVndnlsIHSKQMEGNKK--YLKLIIENILFLG 601
Cdd:pfam14291    2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  602 KQSLSLRGNDQSISTVNKGNFLELLEIRAKdKGEEVFRLLN--SQVDFYNSTQIQNDIIEIIKTEILQDIVNEINVSPaF 679
Cdd:pfam14291   77 HQGLPLRGHDESEESTNKGLFVELLKYTAG-QDEVVKKVLKnaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEMDNDV-F 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  680 SIICDETTDSATKEQLSICVRYPQKMSKavlIKERFLGFIDVEEMTGTNLHRTIKTYLQQIGVDLSKICGQAYDSTMNLR 759
Cdd:pfam14291  155 GILVDETADASDKEQMAIVFRYVDKYGV---PIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMS 231


                   ....
gi 1304918983  760 GKFN 763
Cdd:pfam14291  232 GEFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 1096-1153 1.40e-11

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 61.51  E-value: 1.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1304918983 1096 HNNIPCISKLLYIALSWPVTS-SAENSFSTLprLKTYLCHTMGQEKLSGLALMAIEQEL 1153
Cdd:pfam05699   27 SSRYPNLSKLARDILSIPVSSaASERSFSTL--GKVILESRNRLEPLNVEALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 166-205 7.82e-09

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 52.37  E-value: 7.82e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1304918983  166 LPKKTCSNCSKDILNLKDVISVQLDDSSKNFCSQSCLSSY 205
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
487-567 4.92e-06

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 45.94  E-value: 4.92e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983   487 KSRSIKKSWCSNFQH-LKSSIKKDVTFCYSCQLFCQKNfscGGES--LAAQGISNWKKTLEKFRKHEKSEMH---LKSLQ 560
Cdd:smart00597    1 KPRRFQKSWFHQFPDwLEYSVEKDAAFCKYCYLFRPGR---DGGSdlFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVN 77


                    ....*..
gi 1304918983   561 FWRESQF 567
Cdd:smart00597   78 LMEQRQS 84
TRASH smart00746
metallochaperone-like domain;
171-209 7.05e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 7.05e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1304918983   171 CSNCSKDILNLKDVISVQLDDSSKNFCSQSCLSSYEEKR 209
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 120-157 1.52e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 37.35  E-value: 1.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1304918983  120 AIQVSCSGCKKILQKGQTAY--QRKGSTQLFCSTFCITEY 157
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Name Accession Description Interval E-value
DUF4371 pfam14291
Domain of unknown function (DUF4371);
530-763 5.15e-30

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 119.64  E-value: 5.15e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  530 SLAAQGISNWKK--TLEKFRKHEKSEMH----LKSLQFWRESQFCDEAVndnlsIHSKQMEGNKK--YLKLIIENILFLG 601
Cdd:pfam14291    2 AFLSTGFCSWNKadRLDQFVGHQVNSFHniakRKCEDLMRQGQSIKHIL-----HKETDLEKNDYriWLKASIDIIIHLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  602 KQSLSLRGNDQSISTVNKGNFLELLEIRAKdKGEEVFRLLN--SQVDFYNSTQIQNDIIEIIKTEILQDIVNEINVSPaF 679
Cdd:pfam14291   77 HQGLPLRGHDESEESTNKGLFVELLKYTAG-QDEVVKKVLKnaPKNNTYTSPPIQNDIVNCFSNEVTRSIIEEMDNDV-F 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983  680 SIICDETTDSATKEQLSICVRYPQKMSKavlIKERFLGFIDVEEMTGTNLHRTIKTYLQQIGVDLSKICGQAYDSTMNLR 759
Cdd:pfam14291  155 GILVDETADASDKEQMAIVFRYVDKYGV---PIERFIGVIHVQETSSLSLKSAIDSLLKSLGISLKKLRSQCYDGASNMS 231


                   ....
gi 1304918983  760 GKFN 763
Cdd:pfam14291  232 GEFN 235
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 1096-1153 1.40e-11

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 61.51  E-value: 1.40e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1304918983 1096 HNNIPCISKLLYIALSWPVTS-SAENSFSTLprLKTYLCHTMGQEKLSGLALMAIEQEL 1153
Cdd:pfam05699   27 SSRYPNLSKLARDILSIPVSSaASERSFSTL--GKVILESRNRLEPLNVEALLCIEDWL 83
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 166-205 7.82e-09

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 52.37  E-value: 7.82e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1304918983  166 LPKKTCSNCSKDILNLKDVISVQLDDSSKNFCSQSCLSSY 205
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIVLQNDGSVGQFCSQSCLDSY 40
ZnF_TTF smart00597
zinc finger in transposases and transcription factors;
487-567 4.92e-06

zinc finger in transposases and transcription factors;


Pssm-ID: 214739  Cd Length: 91  Bit Score: 45.94  E-value: 4.92e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1304918983   487 KSRSIKKSWCSNFQH-LKSSIKKDVTFCYSCQLFCQKNfscGGES--LAAQGISNWKKTLEKFRKHEKSEMH---LKSLQ 560
Cdd:smart00597    1 KPRRFQKSWFHQFPDwLEYSVEKDAAFCKYCYLFRPGR---DGGSdlFVTEGFCSWKKERIRLKQHEVSKRHrnaRLCVN 77


                    ....*..
gi 1304918983   561 FWRESQF 567
Cdd:smart00597   78 LMEQRQS 84
TRASH smart00746
metallochaperone-like domain;
171-209 7.05e-06

metallochaperone-like domain;


Pssm-ID: 214799  Cd Length: 39  Bit Score: 43.90  E-value: 7.05e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1304918983   171 CSNCSKDILNLKDVISVQLDDSSKNFCSQSCLSSYEEKR 209
Cdd:smart00746    1 CSFCGKDIYNPGTGIMVVNDGKVYYFCSSKCLSKFKKKR 39
zf-FCS pfam06467
MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM ...
 120-157 1.52e-03

MYM-type Zinc finger with FCS sequence motif; MYM-type zinc fingers were identified in MYM family proteins. Human protein Swiss:Q14202 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. Swiss:Q9UBW7 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged. Members of the family generally are involved in development. This Zn-finger domain functions as a transcriptional trans-activator of late vaccinia viral genes, and orthologues are also found in all nucleocytoplasmic large DNA viruses, NCLDV. This domain is also found fused to the C termini of recombinases from certain prokaryotic transposons.


Pssm-ID: 428958  Cd Length: 40  Bit Score: 37.35  E-value: 1.52e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1304918983  120 AIQVSCSGCKKILQKGQTAY--QRKGSTQLFCSTFCITEY 157
Cdd:pfam06467    1 LVKATCWFCKKLIKNKPTVIvlQNDGSVGQFCSQSCLDSY 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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