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Conserved domains on  [gi|1207923528|ref|XP_021350778|]
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protein FAM134C-like isoform X2 [Mizuhopecten yessoensis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 20-209 1.16e-87

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


:

Pssm-ID: 411697  Cd Length: 192  Bit Score: 266.48  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  20 FKRILSPIEPLVMRIQSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWPEIRVPPAVP 99
Cdd:cd22558     2 LTRLLGPYEPVIMRAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPEPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 100 EDPDSWTPVHPRLLSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVISTL 179
Cdd:cd22558    82 EDPESWTPIHPRLLSVPELCRHLAESWVSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLSLL 161

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207923528 180 LGPSVLYHNLLKRVYLKFEPIFMKMEYSIK 209
Cdd:cd22558   162 LWPLVVYHRVPQKIYTKLEPVLMQLEYSMK 191
 
Name Accession Description Interval E-value
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 20-209 1.16e-87

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411697  Cd Length: 192  Bit Score: 266.48  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  20 FKRILSPIEPLVMRIQSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWPEIRVPPAVP 99
Cdd:cd22558     2 LTRLLGPYEPVIMRAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPEPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 100 EDPDSWTPVHPRLLSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVISTL 179
Cdd:cd22558    82 EDPESWTPIHPRLLSVPELCRHLAESWVSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLSLL 161

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207923528 180 LGPSVLYHNLLKRVYLKFEPIFMKMEYSIK 209
Cdd:cd22558   162 LWPLVVYHRVPQKIYTKLEPVLMQLEYSMK 191
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 37-187 5.36e-04

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 40.55  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  37 LLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTwkhkIWPEI-----RVPPAVPEdpdswtpvhpr 111
Cdd:pfam02453   4 LLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLF----LWAEYagklnRPPPPIPE----------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 112 lLSVPElcQYIAHVWCSCSNILHYWLT-FRRVY----PFLFCVMsCTFFFILAMIGHYIPGLMLAYIIVISTLLGPsVLY 186
Cdd:pfam02453  69 -LELSE--ETVRELADSLRVLINFALSeLRRIAlgedLKLFLKV-AVVLWILSYVGSLFSFLTLLYIGVVLAFTVP-LLY 143


                  .
gi 1207923528 187 H 187
Cdd:pfam02453 144 E 144
 
Name Accession Description Interval E-value
RETR_RHD cd22558
N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This ...
 20-209 1.16e-87

N-terminal reticulon-homology domain of Reticulophagy regulators and similar proteins; This subfamily includes Reticulophagy regulators 1-3. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Members of this subfamily contain an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411697  Cd Length: 192  Bit Score: 266.48  E-value: 1.16e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  20 FKRILSPIEPLVMRIQSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWPEIRVPPAVP 99
Cdd:cd22558     2 LTRLLGPYEPVIMRAQSLLVWEKPLHSAVLLLAVNILFWLATTTSLRVFFLLAVMVMVVVCLDTWKNKIWPEIRVPPEPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 100 EDPDSWTPVHPRLLSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVISTL 179
Cdd:cd22558    82 EDPESWTPIHPRLLSVPELCRHLAESWVSFTIFLQKLWQFRKQHPGKFCLLVCSFCTCLAVIGHYVPGVLLSYIILLSLL 161

                         170       180       190
                  ....*....|....*....|....*....|
gi 1207923528 180 LGPSVLYHNLLKRVYLKFEPIFMKMEYSIK 209
Cdd:cd22558   162 LWPLVVYHRVPQKIYTKLEPVLMQLEYSMK 191
RETR3_RHD cd22562
N-terminal reticulon-homology domain of Reticulophagy regulator 3; Reticulophagy regulator 3 ...
 19-209 2.33e-64

N-terminal reticulon-homology domain of Reticulophagy regulator 3; Reticulophagy regulator 3 (RETR3 or RETREG3), also called FAM134C (family with sequence similarity 134, member C), mediates NRF1-enhanced neurite outgrowth. It interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. RETREG3/FAM134C contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411701  Cd Length: 192  Bit Score: 206.52  E-value: 2.33e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  19 MFKRILSPIEPLVMRIQSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWPEIRVPPAV 98
Cdd:cd22562     1 TLLEVLGPYEPLLSYVQAVLVWERPAHSALWCLGLNAAFWFFALTSLRLVFLLAFSLMIIVCIDQWKNKIWPEIKVARPD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  99 PEDPDSWTPVHPRLLSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVIST 178
Cdd:cd22562    81 ELDNESWGFVHPRLLSVPELCHHVAEVWVSGTNFLRNLLLFKKQNPGKFCLLVCGVLTFLAVLGRYIPGLLLSYLLLLFV 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1207923528 179 LLGPSVLYHNLLKRVYLKFEPIFMKMEYSIK 209
Cdd:cd22562   161 LLWPLAVYHRLGQRIYVKLEPALQRLDFSVR 191
RETR2_RHD cd22561
N-terminal reticulon-homology domain of Reticulophagy regulator 2; Reticulophagy regulator 2 ...
 15-209 2.71e-51

N-terminal reticulon-homology domain of Reticulophagy regulator 2; Reticulophagy regulator 2 (RETR2 or RETREG2), also called FAM134A (family with sequence similarity 134, member A), C2orf17, or MAG2, interacts with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. RETREG2/FAM134A contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an endoplasmic reticulum protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411700  Cd Length: 199  Bit Score: 172.66  E-value: 2.71e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  15 RTENMFKRILSPIEPLVMRIQSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWPEIRV 94
Cdd:cd22561     1 RLATRLRLRLRGWEPVLAAAQRLLVWERPLHSLVTAAALNGLFWLLSSTSLRPFFLLSVSLLGYFLLERWKPRLLPDVSA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  95 PPAVPEDPDS-WTPVHPR--LLSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLA 171
Cdd:cd22561    81 PSPEEPHSDSeGAGSGAQphLLSVPELCHYLAESWLTFQLYLQELLQYKRQNPGQFCARVCSGCAVLAVLGHYVPGIMIS 160

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1207923528 172 YIIVISTLLGPSVLYHNLLKRVYLKFEPIFMKMEYSIK 209
Cdd:cd22561   161 YIVLLSVLLWPLVVYHELIQRMYTRLEPVLMKLDYSMK 198
Arl6IP1_RETR3-like cd21102
ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and ...
 35-207 9.87e-41

ADP-ribosylation factor-like protein 6-interacting protein 1, Reticulophagy regulator 3, and similar proteins; This family contains ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1) and the N-terminal reticulon-homology domain (RHD) of Reticulophagy regulators 1-3. Arl6IP1 is an endoplasmic reticulum (ER) protein that has an important role in cell conduction and material transport. Arl6IP1, a tetraspan membrane protein, is an anti-apoptotic protein specific to multicellular organisms, and is a potential player in shaping the ER tubules in mammalian cells. In Drosophila, knockdown of the Arl6IP1 gene leads to progressive motor deficit. An Arl6IP1 variant has also been associated with hereditary spastic paraplegia (HSP), motor and sensory polyneuropathy, and acromutilation. Reticulophagy regulator 1 (RETREG1/FAM134B) is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. RETREG2/FAM134A and RETREG3/FAM134C has been shown to interact with ATG8 family modifier proteins MAP1LC3A, MAP1LC3B, GABARAP, and GABARAPL1. Arl6IP1 shows some sequence similarity to the RHD of reticulophagy regulators, which may function in inducing membrane curvature.


Pssm-ID: 411696  Cd Length: 178  Bit Score: 144.12  E-value: 9.87e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  35 QSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWP--EIRVPPAVPEDPDSWTPVHPRL 112
Cdd:cd21102     1 QEALVWERPLRSLAIYAALNLLFWFLYYLSLRVFSLLSVFLMFICLIDYWKPIIWRglRPRGARSNKSTSEVGFEFHPML 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 113 LSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVISTLLGPSVLYHNLLKR 192
Cdd:cd21102    81 LSVPELCHNIAESWMSAVIFLLELLQLKEQNPGKFCLLVCVGLAVLAILGQYIPGVLLSYLILTSLLLWPLLNYHGLIDK 160

                         170
                  ....*....|....*...
gi 1207923528 193 VY---LKFEPIFMKMEYS 207
Cdd:cd21102   161 LYgmaKRLHPKLLKLDES 178
RETR1_RHD cd22560
N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 ...
 33-209 4.24e-27

N-terminal reticulon-homology domain of Reticulophagy regulator 1; Reticulophagy regulator 1 (RETR1 or RETREG1), also called reticulophagy receptor 1 or FAM134B (family with sequence similarity 134, member B), is an endoplasmic reticulum (ER)-anchored autophagy receptor that regulates the size and shape of the ER. It regulates turnover of the ER by selective phagocytosis, mediating ER delivery into lysosomes through sequestration into autophagosomes. It promotes membrane remodeling and ER scission through its membrane bending activity, and targets the fragments into autophagosomes by interacting with ATG8 family modifier proteins such as MAP1LC3A, MAP1LC3B, GABARAP, GABARAPL1 and GABARAPL2. Loss of function of FAM134B is associated with diseases and cancer, including hereditary sensory and autonomic neuropathy type IIB (HSAN IIB), colorectal adenocarcinoma, and oesophageal squamous cell carcinoma, and other progressive neuronal degenerative diseases. FAM134B is also implicated in the suppression of viral replication during Ebola, Dengue, Zika, and West Nile viral infections. RETREG1/FAM134B contains an N-terminal reticulon-homology domain (RHD) that shows sequence similarity to ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), an ER protein that has an important role in cell conduction and material transport. The RHD may function in inducing membrane curvature.


Pssm-ID: 411699  Cd Length: 198  Bit Score: 107.92  E-value: 4.24e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  33 RIQSLLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTWKHKIWPEIRVPPAVPEDPDSWTPVHPRL 112
Cdd:cd22560    21 RFDELLSWKRPLRSLLGFVCANLLFWFLALTPWRVYHLISLMILGLVVMQIIKDMVLSRSRGAQLWRSLSESWEVIDSKP 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 113 LSVPELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVISTLLGPSVLYHNLLKR 192
Cdd:cd22560   101 DERPRLSQCIAESWMNFSAFLQEMSHFKQQNPGKFCLLVCSVCTFFTILGSYIPGVVLSYLLLLCAFLCPLFKCNEFGQK 180

                         170
                  ....*....|....*..
gi 1207923528 193 VYLKFEPIFMKMEYSIK 209
Cdd:cd22560   181 VYSKVKSVLQKLDFGIG 197
Arl6IP1 cd22559
ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like 6 ...
 36-213 1.37e-08

ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation factor-like 6 binding factor 1 (Arl6IP1 or Arl6ip-1), also called apoptotic regulator in the membrane of the endoplasmic reticulum (ARMER), is an endoplasmic reticulum (ER) protein that has an important role in cell conduction and material transport. Arl6IP1, a tetraspan membrane protein, is an anti-apoptotic protein specific to multicellular organisms, and is a potential player in shaping the ER tubules in mammalian cells. In neurons, Arl6IP1 has been associated with the regulation of glutamate, a major excitatory neurotransmitter in excitatory synapses. In Drosophila, knockdown of the Arl6IP1 gene leads to progressive motor deficit. An Arl6IP1 variant has also been associated with hereditary spastic paraplegia (HSP), motor and sensory polyneuropathy, and acromutilation. Arl6IP1 shows some sequence similarity to the reticulon-homology domain (RHD) of reticulophagy regulators, which may function in inducing membrane curvature.


Pssm-ID: 411698  Cd Length: 167  Bit Score: 54.19  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  36 SLLVWEYPRKSAVLFICVHGLF---W-----FLAAVGCrfyfVVSTVTYIIYLVQTwkhkIWPEIRvppavpeDPDSWTP 107
Cdd:cd22559     2 KVLRWEKPYYPGIIFGVISLLFlliWyldpsVLTGVSL----LGMILCLLDYLVPT----VAPRIF-------GSNKWTG 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 108 VHPRLLSvpELCQYIAHVWCSCSNILHYWLTFRRVYPFLFCVMSCTFFFILAMIGHYIPGLMLAYIIVISTLLGPSVLYH 187
Cdd:cd22559    67 DQEQRFE--EICSNLVNTKRRLVGWWNRLFNLKEEKPKMYFISVMGSLAAVAWIGNQVHNLLLTYLIVLFLLLLPGLKHH 144

                         170       180
                  ....*....|....*....|....*.
gi 1207923528 188 NLLKRVYlkfepIFMKMEYSIKLKNK 213
Cdd:cd22559   145 GILQKYI-----GMAKRVINKLLKAK 165
Reticulon pfam02453
Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of ...
 37-187 5.36e-04

Reticulon; Reticulon, also know as neuroendocrine-specific protein (NSP), is a protein of unknown function which associates with the endoplasmic reticulum. This family represents the C-terminal domain of the three reticulon isoforms and their homologs.


Pssm-ID: 460562 [Multi-domain]  Cd Length: 157  Bit Score: 40.55  E-value: 5.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528  37 LLVWEYPRKSAVLFICVHGLFWFLAAVGCRFYFVVSTVTYIIYLVQTwkhkIWPEI-----RVPPAVPEdpdswtpvhpr 111
Cdd:pfam02453   4 LLLWRNPKKSGGVFGGATALWLLFEVLGYSLLSLVSKLLLLLLLVLF----LWAEYagklnRPPPPIPE----------- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207923528 112 lLSVPElcQYIAHVWCSCSNILHYWLT-FRRVY----PFLFCVMsCTFFFILAMIGHYIPGLMLAYIIVISTLLGPsVLY 186
Cdd:pfam02453  69 -LELSE--ETVRELADSLRVLINFALSeLRRIAlgedLKLFLKV-AVVLWILSYVGSLFSFLTLLYIGVVLAFTVP-LLY 143


                  .
gi 1207923528 187 H 187
Cdd:pfam02453 144 E 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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