Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1207108130  588 QVLVETDIQWPNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNR 630
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207108130  504 VIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVANFNGT 541
Cdd:smart00135   4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGT 41

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207108130   67 TCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1207108130 272 RNCRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1207108130 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 356 CLINNGGCSHICRDLTIGFECDCTPGLQLI-DRKTC 390
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1207108130 708 NGGCSFMCLPAPQinkhspKYTCVCPEGQTLASDGLRC 745
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207108130 235 CSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207108130  29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1207108130  544 KVLFNSGLKEPASIAVDPLSGFLYWSDWGEPaKIEKSGMNGNDR 587
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207108130   67 TCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207108130  234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDE 266
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1207108130  66 KTCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1207108130  68 CAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207108130 274 CRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1207108130 109 CRVNEFSCGVGstQCIPVFWKCDGEKDCDNGEDEINC 145
Cdd:cd00112     1 CPPNEFRCANG--RCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1207108130 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 479 IFWADLGQKAIfsTVLDKQDESHKKVIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVanFNGTKKKVL--FNSGlKEPAS 556
Cdd:COG3391    82 LYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVatIPVG-AGPHG 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207108130 557 IAVDPLSGFLYWSDWGEP--AKIEkSGMNGNDRQVLVETDI-QWPNGITLDLIKGRLYWVD 614
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNtvSVIV-SVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVAN 216

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1207108130 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:pfam00057   4 SPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 356 CLINNGGCSHICRDLTIGFECDCTPGLQLI-DRKTC 390
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQdDGRTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1207108130 392 DVNECLNPGICS--QICINLKGGYKCECHNGYQ 422
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1207108130 708 NGGCSFMCLPAPQinkhspKYTCVCPEGQTLASDGLRC 745
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1207108130 479 IFWADLGQKA-IFSTVLDKQDEsHKKVIDDVQMPVGIAVDW 518
Cdd:pfam00058   3 LYWTDSSLRAsISSADLNGSDR-KTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207108130 235 CSPSEMQCGSGECIHRKWRCDGDPDCKDGSDEKNC 269
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207108130  29 CEQSQFQCGNGRCIPSVWQCDGDMDCSDGSDETSC 63
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1207108130  544 KVLFNSGLKEPASIAVDPLSGFLYWSDWGEPaKIEKSGMNGNDR 587
Cdd:smart00135   1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLD-VIEVANLDGTNR 43

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1207108130 149 TCAPLEFTCSSGRCVSRKFVCNGEDDCGDGSDEQDC 184
Cdd:pfam00057   2 TCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207108130   67 TCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207108130  234 KCSPSEMQCGSGECIHRKWRCDGDPDCKDGSDE 266
Cdd:smart00192   1 TCPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Low-density lipoprotein receptor domain class A;

                          10        20        30
                  ....*....|....*....|....*....|....
gi 1207108130  66 KTCAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDE 34

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|..
gi 1207108130  68 CAEVDFVCRSGQCIPKRWQCDGEPDCEDGSDE 99
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1207108130 274 CRPDQFKCDDGSCIHGSRQCNGFRDCVDGTDEVNC 308
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 479 IFWADLGQKAIfsTVLDKQDE-----SHKKVIDDVQMPVGIAVDwiYKNIYWSDLGSKSITVANFNGTKKKVLFNSG--- 550
Cdd:cd14963    69 IYVADLYNGRI--QVFDPDGKflkyfPEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPGsep 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 551 --LKEPASIAVDPlSGFLYWSDW-----------GEPAKIEKSGMNGNDRQVLvetdiqwPNGITLDLiKGRLYWVDSKL 617
Cdd:cd14963   145 geLSYPNGIAVDE-DGNIYVADSgngriqvfdknGKFIKELNGSPDGKSGFVN-------PRGIAVDP-DGNLYVVDNLS 215

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1207108130 618 HMLCSVDLNGDNRRKVLQS---PDYLAHPFALTVFED-RVFWTDGENEAIY 664
Cdd:cd14963   216 HRVYVFDEQGKELFTFGGRgkdDGQFNLPNGLFIDDDgRLYVTDRENNRVA 266

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1207108130 522 NIYWSDLGSK-SITVANFNGTKKKVLFNSGLKEPASIAVDP 561
Cdd:pfam00058   2 RLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

                          10        20        30
                  ....*....|....*....|....*....|.
gi 1207108130 316 SSDQFKCRSGECIEMSKVCNKVRDCPDWSDE 346
Cdd:cd00112     2 PPNEFRCANGRCIPSSWVCDGEDDCGDGSDE 32

DNA-binding beta-propeller fold protein YncE [General function prediction only];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 479 IFWADLGQKAIfsTVLDKQDESHKKVIDDVQMPVGIAVDWIYKNIYWSDLGSKSITVanFNGTKKKVL--FNSGlKEPAS 556
Cdd:COG3391    82 LYVANSGSGRV--SVIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVatIPVG-AGPHG 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207108130 557 IAVDPLSGFLYWSDWGEP--AKIEkSGMNGNDRQVLVETDI-QWPNGITLDLIKGRLYWVD 614
Cdd:COG3391   157 IAVDPDGKRLYVANSGSNtvSVIV-SVIDTATGKVVATIPVgGGPVGVAVSPDGRRLYVAN 216

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 503 KVIDDVQMPVGIAVDWIYKnIYWSDLGSKSITVANFNGTKKKVLFNSG---LKEPASIAVDPlSGFLYWSDwGEPAKIEK 579
Cdd:cd14962     6 RPKEALTRPYGVAADGRGR-IYVADTGRGAVFVFDLPNGKVFVIGNAGpnrFVSPIGVAIDA-NGNLYVSD-AELGKVFV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 580 SGMNGNDRQVLVETDIQW-PNGITLDLIKGRLYWVDSKLHMLCSVDLNGDNRRKVLQS---PDYLAHPFALTVF-EDRVF 654
Cdd:cd14962    83 FDRDGKFLRAIGAGALFKrPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIGKRgsgPGEFNLPTDLAVDrDGNLY 162

                  ....*.
gi 1207108130 655 WTDGEN 660
Cdd:cd14962   163 VTDTMN 168

Calcium-binding EGF-like domain;

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207108130  392 DVNECLNPGICSQ--ICINLKGGYKCECHNGYQMDPT 426
Cdd:smart00179   1 DIDECASGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1207108130 608 GRLYWVDSKLH-MLCSVDLNGDNRRKVLQspDYLAHPFALTVFE 650
Cdd:pfam00058   1 GRLYWTDSSLRaSISSADLNGSDRKTLFT--DDLQHPNAIAVDP 42

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1207108130 392 DVNECLNPGICS--QICINLKGGYKCECHNGYQ 422
Cdd:cd00054     1 DIDECASGNPCQngGTCVNTVGSYRCSCPPGYT 33

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207108130 511 PVGIAVDWiyKNIYWSDLGSKSITVANFNGTKKKVLFNSGLKE-----PASIAVDPlSGFLYWSDWGEpAKIEKSGMNGN 585
Cdd:cd14963    12 PMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLYN-GRIQVFDPDGK 87

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207108130 586 DRQVLVETD----IQWPNGITLDliKGRLYWVDSKLHMLCSVDLNGdnrRKVL------QSPDYLAHPFALTVFEDR 652
Cdd:cd14963    88 FLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEG---KLLLefgkpgSEPGELSYPNGIAVDEDG 159

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1207108130 708 NGGCSFMCLPAPQinkhspKYTCVCPEGQTLASDGLRC 745
Cdd:pfam14670   5 NGGCSHLCLNTPG------GYTCSCPEGYELQDDGRTC 36