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Conserved domains on  [gi|1207182659|ref|XP_021333897|]
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sulfotransferase family 1, cytosolic sulfotransferase 4 isoform X1 [Danio rerio]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-305 1.37e-87

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 262.66  E-value: 1.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659  46 PDDILIATYPKAGysaiknprTTWVSYILDLLYFGNDENQTSQPIV----QRVPFLESCFQE--FSTISGTEMADNLPtS 119
Cdd:pfam00685   1 DDDVLIVTYPKSG--------TTWLQEILSLIPNRGDFEKSEEPHLfnnhNRSPFLEWYPGDtyFDVAEGPVRLNALP-S 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 120 PRLIKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPEPGDWDSYLDKFMQGQNVFGSWFDHVSGWWQ 199
Cdd:pfam00685  72 PRIIKTHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 200 KKRSyPNMLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKGVQFDAMKQNTLINHVTIPfldCKISPFMRKGKVG 279
Cdd:pfam00685 152 LRPP-GNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---KEVSPFFRKGLVG 227

                         250       260
                  ....*....|....*....|....*.
gi 1207182659 280 DWKSHFTVAQNERFDEVYKQKMKNSG 305
Cdd:pfam00685 228 DWKNYFTPEQAEKFDEIYQEKMKGTG 253
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-305 1.37e-87

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 262.66  E-value: 1.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659  46 PDDILIATYPKAGysaiknprTTWVSYILDLLYFGNDENQTSQPIV----QRVPFLESCFQE--FSTISGTEMADNLPtS 119
Cdd:pfam00685   1 DDDVLIVTYPKSG--------TTWLQEILSLIPNRGDFEKSEEPHLfnnhNRSPFLEWYPGDtyFDVAEGPVRLNALP-S 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 120 PRLIKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPEPGDWDSYLDKFMQGQNVFGSWFDHVSGWWQ 199
Cdd:pfam00685  72 PRIIKTHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 200 KKRSyPNMLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKGVQFDAMKQNTLINHVTIPfldCKISPFMRKGKVG 279
Cdd:pfam00685 152 LRPP-GNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---KEVSPFFRKGLVG 227

                         250       260
                  ....*....|....*....|....*.
gi 1207182659 280 DWKSHFTVAQNERFDEVYKQKMKNSG 305
Cdd:pfam00685 228 DWKNYFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 40-306 4.93e-29

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 113.86  E-value: 4.93e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659  40 KNFQARPDDILIATYPKAGysaiknprTTWVSYILDLLYFGNDENQTSQPIVQR-----VPFLESCFQEFSTISGTEMAD 114
Cdd:PLN02164   73 EFFQARPNDFLVCSYPKTG--------TTWLKALTFAIANRSRFDDSSNPLLKRnphefVPYIEIDFPFFPSVDVLKDKG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 115 NlptspRLIKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPEP-GDWDSYLDKFMQGQNVFGSWFDH 193
Cdd:PLN02164  145 N-----TLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDH 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 194 VSGWWQKKRSYPN-MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEK-----EKITKGVQFDAMKqNTLIN-----HVTI 262
Cdd:PLN02164  220 VLGYWKAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEekgvvEKVVKLCSFETLK-NLEANkgekdREDR 298

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1207182659 263 PFLDCKiSPFMRKGKVGDWKSHFTVAQNERFDEVYKQKMKNSGV 306
Cdd:PLN02164  299 PAVYAN-SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
207-258 3.36e-04

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 41.15  E-value: 3.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207182659 207 MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKgvqfdamKQNTLIN 258
Cdd:COG4424   176 PLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK-------KQADEPS 220
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
46-305 1.37e-87

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 262.66  E-value: 1.37e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659  46 PDDILIATYPKAGysaiknprTTWVSYILDLLYFGNDENQTSQPIV----QRVPFLESCFQE--FSTISGTEMADNLPtS 119
Cdd:pfam00685   1 DDDVLIVTYPKSG--------TTWLQEILSLIPNRGDFEKSEEPHLfnnhNRSPFLEWYPGDtyFDVAEGPVRLNALP-S 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 120 PRLIKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPEPGDWDSYLDKFMQGQNVFGSWFDHVSGWWQ 199
Cdd:pfam00685  72 PRIIKTHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWK 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 200 KKRSyPNMLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKGVQFDAMKQNTLINHVTIPfldCKISPFMRKGKVG 279
Cdd:pfam00685 152 LRPP-GNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLP---KEVSPFFRKGLVG 227

                         250       260
                  ....*....|....*....|....*.
gi 1207182659 280 DWKSHFTVAQNERFDEVYKQKMKNSG 305
Cdd:pfam00685 228 DWKNYFTPEQAEKFDEIYQEKMKGTG 253
PLN02164 PLN02164
sulfotransferase
 40-306 4.93e-29

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 113.86  E-value: 4.93e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659  40 KNFQARPDDILIATYPKAGysaiknprTTWVSYILDLLYFGNDENQTSQPIVQR-----VPFLESCFQEFSTISGTEMAD 114
Cdd:PLN02164   73 EFFQARPNDFLVCSYPKTG--------TTWLKALTFAIANRSRFDDSSNPLLKRnphefVPYIEIDFPFFPSVDVLKDKG 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 115 NlptspRLIKTHLPVQLVPKSFWEQNSRVVYVARNAKDNAVSYFHFDRMNMVQPEP-GDWDSYLDKFMQGQNVFGSWFDH 193
Cdd:PLN02164  145 N-----TLFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFLHKERSQQGPlNSLEESFDMFCRGLSVYGPYLDH 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 194 VSGWWQKKRSYPN-MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEK-----EKITKGVQFDAMKqNTLIN-----HVTI 262
Cdd:PLN02164  220 VLGYWKAYQENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEekgvvEKVVKLCSFETLK-NLEANkgekdREDR 298

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1207182659 263 PFLDCKiSPFMRKGKVGDWKSHFTVAQNERFDEVYKQKMKNSGV 306
Cdd:PLN02164  299 PAVYAN-SAYFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
LpsS COG4424
LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];
207-258 3.36e-04

LPS sulfotransferase NodH [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443539  Cd Length: 238  Bit Score: 41.15  E-value: 3.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1207182659 207 MLYMFFEDLSEDTGREVNRLCSFLGLSTSVQEKEKITKgvqfdamKQNTLIN 258
Cdd:COG4424   176 PLEITYEDLAADPVEVLNRVLDFLGVDPPLAPLRPALK-------KQADEPS 220
Sulfotransfer_3 pfam13469
Sulfotransferase family;
140-235 2.38e-03

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 38.04  E-value: 2.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207182659 140 NSRVVYVARNAKDNAVSyfhfDRMNMVQPEPGDWdSYLDKFMQGQNVfGSWFDHVSGWWQKKRSYP--NMLYMFFEDLSE 217
Cdd:pfam13469  81 DAKFIHLHRDPVDTVIS----SYCSLFGFTLSSY-STAFLRDIGLAL-ARWSRAYERLMAARARVPpgRFLDVRYEDLVA 154

                          90
                  ....*....|....*...
gi 1207182659 218 DTGREVNRLCSFLGLSTS 235
Cdd:pfam13469 155 DPEGTLRRILEFLGLPWD 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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