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Conserved domains on  [gi|1207106434|ref|XP_021331532|]
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slit homolog 2 protein isoform X6 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1193-1319 1.17e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 117.91  E-value: 1.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434 1193 TDEDNGVLLYKGD--NEHIAVELYRGRLRVSYDSGSYPPSAIYSVETINDGSFHVVELVAKDQSLSLSIDGGSPKSINTA 1270
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1207106434 1271 NSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYINDQ 1319
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLP-----PLLLLPALPVRAGFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-204 1.01e-25

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 1.01e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   30 TAVDCHGQSLRSVPRNIPR--NVERLDLNANNLTKITKAdFAGLKNLRVLQLMENKISSIERgAFQDLQELERLRLNRNN 107
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  108 LQVLPELLFlGTTKLFRLDLSENQIQGIPrKAFRGSTEIKNLQLDYNQISCIEDgaFRALRDLEVLTLNNNNISRLSVAS 187
Cdd:COG4886    194 ITDLPEPLG-NLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                          170
                   ....*....|....*..
gi 1207106434  188 fnHMPKLRTFRLHSNNL 204
Cdd:COG4886    270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
547-844 6.82e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 6.82e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  547 NLSNNKITDIEEGTFEGASGVNELILTSNRLEGVHYSMLKGLGGLRTLMLRsnriscvNNGSFTGLSSVRLLSLYDNLIT 626
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  627 SMsPGAFDTLHSLSTLNLLANPfncnchlawlgewlrkkrivtgnprcqspyfLKEIPiqdvavqdfaceegndenscSP 706
Cdd:COG4886    127 DL-PEELANLTNLKELDLSNNQ-------------------------------LTDLP--------------------EP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  707 LARCPAecscLdTVVRCSNKGLKVLPKGIPR--DVTELYLDGNEFTQVPLELSNYKHLTLIDLSNNQISTLSNhSFSNMS 784
Cdd:COG4886    155 LGNLTN----L-KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLT 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  785 ELLTLILSYNRLRCIPakAFDGLKSLRLLSLHGNDIAVIPDGAfkDLSSLSHLALGANPL 844
Cdd:COG4886    229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
310-650 1.49e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  310 AFAPYKRLRRIDLSNNQITELaSDSFQGLRSLNSLVLYGNKITELPKGLFdglfslqllllnankinclrvdsfqDLQNL 389
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-------------------------NLTNL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  390 NLLSLYDNKLQTIAKgtfsslrAIQTLHlaqnpfmcdcHLKWLadYLQDNPIETsgarctsprrlANKRIGQIKskkfrc 469
Cdd:COG4886    162 KSLDLSNNQLTDLPE-------ELGNLT----------NLKEL--DLSNNQITD-----------LPEPLGNLT------ 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  470 sgvedyrsKLggdcfadlacpekcrcegTTVDCSGQKLTKIPDHIPQYTA--ELRLNNNEFTVLEAtgiFKKLPQLRKIN 547
Cdd:COG4886    206 --------NL------------------EELDLSGNQLTDLPEPLANLTNleTLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  548 LSNNKITDIEEgtfegasgvneliltsnrlegvhysmLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITS 627
Cdd:COG4886    257 LSNNQLTDLPP--------------------------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                          330       340
                   ....*....|....*....|...
gi 1207106434  628 MSPGAFDTLHSLSTLNLLANPFN 650
Cdd:COG4886    311 LELLILLLLLTTLLLLLLLLKGL 333
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1115 1.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207106434 1079 DFDDCED-NKCKNGAQCIDAVNGYTCVCPEGYSGLFCE 1115
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 815-1007 5.11e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 54.70  E-value: 5.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  815 LHGNDIAVIPDGAFKDLSSLSHLALGANPLYCDCHMQWLSDWVKSG---YKEPGIARCTGPGDMTDKLLLTTPSKKFTCt 891
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  892 evpgtcgfpvpgpvDVSILAkcnpCLSNPCKNDGTCSNHPVDFYRCTcPYGFKGQDCEEpihACISnpcqnggTCHLKDG 971
Cdd:TIGR00864   81 --------------DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFS-------AGHGLAA 131

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1207106434  972 EENTHWCVCPEGFEGDECEINIDDCEDNDCENNSTC 1007
Cdd:TIGR00864  132 LGEQGECLCGAAQPSEANFACESLCSGPPPPPAAAC 167
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 175-237 2.87e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 2.87e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434  175 LNNNNISRLSVASFNHMPKLRTFRLHSNNLLCDCNVAWLSDWLRQ---RPRLGLYTQCMAPPSLRG 237
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvKVRQPEAALCAGPGALAG 67
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1470-1531 2.16e-05

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 44.32  E-value: 2.16e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207106434  1470 YAACQStEKVSRLECRGSCGDGT-----------SCCAPLRSKRRKYTFQCTDGSSFVQEVEKVVKCGCT-KCP 1531
Cdd:smart00041   10 YNGCTS-VTVKNAFCEGKCGSASsysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEpNCP 82
LRRNT smart00013
Leucine rich repeat N-terminal domain;
263-295 2.51e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.51e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207106434   263 QCPELCTCSNNVVDCRGKGLTEIPTNLPETITE 295
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1041-1077 4.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.71e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207106434 1041 DFCASElNLCQHDSKCILTAKGFMCECTPGYTGEHCE 1077
Cdd:cd00054      3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 996-1023 6.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 1207106434  996 CEDNDCENNSTCVDGINNYTCLCSPEYT 1023
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1193-1319 1.17e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 117.91  E-value: 1.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434 1193 TDEDNGVLLYKGD--NEHIAVELYRGRLRVSYDSGSYPPSAIYSVETINDGSFHVVELVAKDQSLSLSIDGGSPKSINTA 1270
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1207106434 1271 NSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYINDQ 1319
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLP-----PLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1186-1319 1.51e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.74  E-value: 1.51e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  1186 NISLQIATDEDNGVLLY---KGDNEHIAVELYRGRLRVSYDSGSYPPSAIYSVETINDGSFHVVELVAKDQSLSLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207106434  1263 SPKSINTANSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYINDQ 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1164-1317 5.71e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 113.67  E-value: 5.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434 1164 SVNFiNRESFLQIP-SNLITEQANISLQIATDEDNGVLLYKGD---NEHIAVELYRGRLRVSYDSGSypPSAIYSVET-I 1238
Cdd:cd00110      1 GVSF-SGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434 1239 NDGSFHVVELVAKDQSLSLSIDGGSPKSINTANSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYIN 1317
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP-----EDLKSPGLPVSPGFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-204 1.01e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 1.01e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   30 TAVDCHGQSLRSVPRNIPR--NVERLDLNANNLTKITKAdFAGLKNLRVLQLMENKISSIERgAFQDLQELERLRLNRNN 107
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  108 LQVLPELLFlGTTKLFRLDLSENQIQGIPrKAFRGSTEIKNLQLDYNQISCIEDgaFRALRDLEVLTLNNNNISRLSVAS 187
Cdd:COG4886    194 ITDLPEPLG-NLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                          170
                   ....*....|....*..
gi 1207106434  188 fnHMPKLRTFRLHSNNL 204
Cdd:COG4886    270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
547-844 6.82e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 6.82e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  547 NLSNNKITDIEEGTFEGASGVNELILTSNRLEGVHYSMLKGLGGLRTLMLRsnriscvNNGSFTGLSSVRLLSLYDNLIT 626
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  627 SMsPGAFDTLHSLSTLNLLANPfncnchlawlgewlrkkrivtgnprcqspyfLKEIPiqdvavqdfaceegndenscSP 706
Cdd:COG4886    127 DL-PEELANLTNLKELDLSNNQ-------------------------------LTDLP--------------------EP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  707 LARCPAecscLdTVVRCSNKGLKVLPKGIPR--DVTELYLDGNEFTQVPLELSNYKHLTLIDLSNNQISTLSNhSFSNMS 784
Cdd:COG4886    155 LGNLTN----L-KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLT 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  785 ELLTLILSYNRLRCIPakAFDGLKSLRLLSLHGNDIAVIPDGAfkDLSSLSHLALGANPL 844
Cdd:COG4886    229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
310-650 1.49e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  310 AFAPYKRLRRIDLSNNQITELaSDSFQGLRSLNSLVLYGNKITELPKGLFdglfslqllllnankinclrvdsfqDLQNL 389
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-------------------------NLTNL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  390 NLLSLYDNKLQTIAKgtfsslrAIQTLHlaqnpfmcdcHLKWLadYLQDNPIETsgarctsprrlANKRIGQIKskkfrc 469
Cdd:COG4886    162 KSLDLSNNQLTDLPE-------ELGNLT----------NLKEL--DLSNNQITD-----------LPEPLGNLT------ 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  470 sgvedyrsKLggdcfadlacpekcrcegTTVDCSGQKLTKIPDHIPQYTA--ELRLNNNEFTVLEAtgiFKKLPQLRKIN 547
Cdd:COG4886    206 --------NL------------------EELDLSGNQLTDLPEPLANLTNleTLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  548 LSNNKITDIEEgtfegasgvneliltsnrlegvhysmLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITS 627
Cdd:COG4886    257 LSNNQLTDLPP--------------------------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                          330       340
                   ....*....|....*....|...
gi 1207106434  628 MSPGAFDTLHSLSTLNLLANPFN 650
Cdd:COG4886    311 LELLILLLLLTTLLLLLLLLKGL 333
LRR_8 pfam13855
Leucine rich repeat;
761-820 2.32e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 71.79  E-value: 2.32e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  761 HLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLKSLRLLSLHGNDI 820
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
48-108 2.48e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 2.48e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNL 108
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-207 7.82e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 7.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   53 LDLNANNLTKITkaDFAGLKNLRVLQLMENKISSIErgAFQDLQELERLRLNRNNLQVLPELLFLgtTKLFRLDLSENQI 132
Cdd:cd21340      7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLENL--VNLKKLYLGGNRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  133 QGIprKAFRGSTEIKNLQLDYNQIS-----CIEDGAFRALRD-LEVLTLNNNNISrlSVASFNHMPKLRTFRLhSNNLLC 206
Cdd:cd21340     81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDA-SNNQIS 155


                   .
gi 1207106434  207 D 207
Cdd:cd21340    156 D 156
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-204 2.43e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 2.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNN-LQVLPEllFLGTTKLFRLD 126
Cdd:PLN00113   404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPD--SFGSKRLENLD 481

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434  127 LSENQIQG-IPRKaFRGSTEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNL 204
Cdd:PLN00113   482 LSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 620-697 1.87e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.79  E-value: 1.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  620 LYDNLITSMSPGAFDTLHSLSTLNLLANPFNCNCHLAWLGEWLRKKRIVTGNPR---CQSPYFLKEIPIQDVAVQDFACE 696
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   .
gi 1207106434  697 E 697
Cdd:TIGR00864   82 E 82
LRR_8 pfam13855
Leucine rich repeat;
294-351 2.62e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 2.62e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207106434  294 TEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGLRSLNSLVLYGNKI 351
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
679-844 2.34e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 2.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  679 FLKEIPIQDVAVQDFACEEGNDenscsplarcpaecsCL---DTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLE 755
Cdd:PRK15370   153 WVKEAPAKEAANREEAVQRMRD---------------CLknnKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  756 L-SNYKHLT------------------LIDLSNNQISTLSNHSfsnMSELLTLILSYNRLRCIPAKAFDGlksLRLLSLH 816
Cdd:PRK15370   218 LqGNIKTLYansnqltsipatlpdtiqEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEE---LRYLSVY 291

                          170       180
                   ....*....|....*....|....*...
gi 1207106434  817 GNDIAVIPDGAfkdLSSLSHLALGANPL 844
Cdd:PRK15370   292 DNSIRTLPAHL---PSGITHLNVQSNSL 316
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1115 1.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207106434 1079 DFDDCED-NKCKNGAQCIDAVNGYTCVCPEGYSGLFCE 1115
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-399 2.15e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQ-VLPELLFlGTTKLFRLD 126
Cdd:PLN00113   212 KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLD 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  127 LSENQIQG-IPRKAFR-GSTEIknLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNL 204
Cdd:PLN00113   291 LSDNSLSGeIPELVIQlQNLEI--LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  205 -------LCDCNvawlsdwlrqrprlGLYTQCMAPPSLRGhniaEVqkkefmctgPQSHSSCSVLQCPELCtcSNNVVDC 277
Cdd:PLN00113   369 tgeipegLCSSG--------------NLFKLILFSNSLEG----EI---------PKSLGACRSLRRVRLQ--DNSFSGE 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  278 RGKGLTEIP---------TNLPETITEIRLEQNSIKIIPAGA---------FAPYKRLRRIDLSNNQITELASDSFQGLR 339
Cdd:PLN00113   420 LPSEFTKLPlvyfldisnNNLQGRINSRKWDMPSLQMLSLARnkffgglpdSFGSKRLENLDLSRNQFSGAVPRKLGSLS 499

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  340 SLNSLVLYGNKIT-ELPKGLfDGLFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKL 399
Cdd:PLN00113   500 ELMQLKLSENKLSgEIPDEL-SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 815-1007 5.11e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 54.70  E-value: 5.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  815 LHGNDIAVIPDGAFKDLSSLSHLALGANPLYCDCHMQWLSDWVKSG---YKEPGIARCTGPGDMTDKLLLTTPSKKFTCt 891
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  892 evpgtcgfpvpgpvDVSILAkcnpCLSNPCKNDGTCSNHPVDFYRCTcPYGFKGQDCEEpihACISnpcqnggTCHLKDG 971
Cdd:TIGR00864   81 --------------DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFS-------AGHGLAA 131

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1207106434  972 EENTHWCVCPEGFEGDECEINIDDCEDNDCENNSTC 1007
Cdd:TIGR00864  132 LGEQGECLCGAAQPSEANFACESLCSGPPPPPAAAC 167
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 737-837 7.29e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 7.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  737 RDVTELYLDGNEFTQVPlELSNYKHLTLIDLSNNQISTLSNhsFSNMSELLTLILSYNRLRCIPAkaFDGLKSLRLLSLH 816
Cdd:cd21340      2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                           90       100
                   ....*....|....*....|.
gi 1207106434  817 GNDIAVIpDGaFKDLSSLSHL 837
Cdd:cd21340     77 GNRISVV-EG-LENLTNLEEL 95
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 175-237 2.87e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 2.87e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434  175 LNNNNISRLSVASFNHMPKLRTFRLHSNNLLCDCNVAWLSDWLRQ---RPRLGLYTQCMAPPSLRG 237
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvKVRQPEAALCAGPGALAG 67
EGF_CA smart00179
Calcium-binding EGF-like domain;
1079-1115 3.06e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.06e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1207106434  1079 DFDDCE-DNKCKNGAQCIDAVNGYTCVCPEGYS-GLFCE 1115
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
281-410 4.14e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 4.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  281 GLTEIPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRridLSNNQITELAS---DSFQGLRslnslvLYGNKITELPKG 357
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSIPAtlpDTIQEME------LSINRITELPER 259

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207106434  358 LfdgLFSLQLLLLNANKINCLRvDSFQDlqNLNLLSLYDNKLQTIAKGTFSSL 410
Cdd:PRK15370   260 L---PSALQSLDLFHNKISCLP-ENLPE--ELRYLSVYDNSIRTLPAHLPSGI 306
LRRNT smart00013
Leucine rich repeat N-terminal domain;
710-741 8.37e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 8.37e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207106434   710 CPAECSCLDTVVRCSNKGLKVLPKGIPRDVTE 741
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1083-1111 1.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.46e-05
                           10        20
                   ....*....|....*....|....*....
gi 1207106434 1083 CEDNKCKNGAQCIDAVNGYTCVCPEGYSG 1111
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRCT smart00082
Leucine rich repeat C-terminal domain;
842-891 1.46e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.57  E-value: 1.46e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1207106434   842 NPLYCDCHMQWLSDWV--KSGYKEPGIARCTGPGDMTDKLLLTTPSkKFTCT 891
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1470-1531 2.16e-05

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 44.32  E-value: 2.16e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207106434  1470 YAACQStEKVSRLECRGSCGDGT-----------SCCAPLRSKRRKYTFQCTDGSSFVQEVEKVVKCGCT-KCP 1531
Cdd:smart00041   10 YNGCTS-VTVKNAFCEGKCGSASsysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEpNCP 82
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 394-457 2.29e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.29e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207106434  394 LYDNKLQTIAKGTFSSLRAIQTLHLAQNPFMCDCHLKWLADYLQDNPIET---SGARCTSPRRLANK 457
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-51 2.34e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.34e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1207106434    21 CPSQCSCSGTAVDCHGQSLRSVPRNIPRNVE 51
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT smart00013
Leucine rich repeat N-terminal domain;
263-295 2.51e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.51e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207106434   263 QCPELCTCSNNVVDCRGKGLTEIPTNLPETITE 295
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
488-518 3.51e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 3.51e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1207106434   488 ACPEKCRCEGTTVDCSGQKLTKIPDHIPQYT 518
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1041-1077 4.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.71e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207106434 1041 DFCASElNLCQHDSKCILTAKGFMCECTPGYTGEHCE 1077
Cdd:cd00054      3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 914-949 1.96e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.96e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207106434  914 NPCLS-NPCKNDGTCSNHPVDfYRCTCPYGFKGQDCE 949
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 279-424 2.47e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 2.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  279 GKGLTEIPT-NLPETITEIRLEQNSIKIIPAGAFAPykRLRRIDLSNNQITELasDSFQGLRSLNSLVLYGNKITE---- 353
Cdd:cd21340     11 DKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLT--NLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVvegl 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  354 ---------------LPKG---LFDGLFSLQLLllnankiNCLRV-----------DSFQDLQNLNLLSLYDNKLQTIA- 403
Cdd:cd21340     87 enltnleelhienqrLPPGeklTFDPRSLAALS-------NSLRVlnisgnnidslEPLAPLRNLEQLDASNNQISDLEe 159

                          170       180
                   ....*....|....*....|..
gi 1207106434  404 -KGTFSSLRAIQTLHLAQNPFM 424
Cdd:cd21340    160 lLDLLSSWPSLRELDLTGNPVC 181
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 263-290 3.64e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.15  E-value: 3.64e-04
                           10        20
                   ....*....|....*....|....*...
gi 1207106434  263 QCPELCTCSNNVVDCRGKGLTEIPTNLP 290
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
202-237 2.96e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.02  E-value: 2.96e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1207106434   202 NNLLCDCNVAWLSDWLRQRPRL--GLYTQCMAPPSLRG 237
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 955-987 4.52e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.52e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207106434  955 CISNPCQNGGTCHLKdgeENTHWCVCPEGFEGD 987
Cdd:pfam00008    1 CAPNPCSNGGTCVDT---PGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 996-1023 6.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 1207106434  996 CEDNDCENNSTCVDGINNYTCLCSPEYT 1023
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1075 9.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.84e-03
                           10        20
                   ....*....|....*....|....*.
gi 1207106434 1050 CQHDSKCILTAKGFMCECTPGYTGEH 1075
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1193-1319 1.17e-30

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 117.91  E-value: 1.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434 1193 TDEDNGVLLYKGD--NEHIAVELYRGRLRVSYDSGSYPPSAIYSVETINDGSFHVVELVAKDQSLSLSIDGGSPKSINTA 1270
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1207106434 1271 NSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYINDQ 1319
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLP-----PLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1186-1319 1.51e-29

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 114.74  E-value: 1.51e-29
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  1186 NISLQIATDEDNGVLLY---KGDNEHIAVELYRGRLRVSYDSGSYPPSAIYSVETINDGSFHVVELVAKDQSLSLSIDGG 1262
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207106434  1263 SPKSINTANSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYINDQ 1319
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLP-----EDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1164-1317 5.71e-29

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 113.67  E-value: 5.71e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434 1164 SVNFiNRESFLQIP-SNLITEQANISLQIATDEDNGVLLYKGD---NEHIAVELYRGRLRVSYDSGSypPSAIYSVET-I 1238
Cdd:cd00110      1 GVSF-SGSSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYDLGS--GSLVLSSKTpL 77

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434 1239 NDGSFHVVELVAKDQSLSLSIDGGSPKSINTANSPSPVPSPAPLYLGGLPqqsglASLRQGSGRNGSSFHGCIRNLYIN 1317
Cdd:cd00110     78 NDGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLP-----EDLKSPGLPVSPGFVGCIRDLKVN 151
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-204 1.01e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 111.95  E-value: 1.01e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   30 TAVDCHGQSLRSVPRNIPR--NVERLDLNANNLTKITKAdFAGLKNLRVLQLMENKISSIERgAFQDLQELERLRLNRNN 107
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQ 193

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  108 LQVLPELLFlGTTKLFRLDLSENQIQGIPrKAFRGSTEIKNLQLDYNQISCIEDgaFRALRDLEVLTLNNNNISRLSVAS 187
Cdd:COG4886    194 ITDLPEPLG-NLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPPLA 269

                          170
                   ....*....|....*..
gi 1207106434  188 fnHMPKLRTFRLHSNNL 204
Cdd:COG4886    270 --NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
547-844 6.82e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 103.47  E-value: 6.82e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  547 NLSNNKITDIEEGTFEGASGVNELILTSNRLEGVHYSMLKGLGGLRTLMLRsnriscvNNGSFTGLSSVRLLSLYDNLIT 626
Cdd:COG4886     54 SLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLS-------GNEELSNLTNLESLDLSGNQLT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  627 SMsPGAFDTLHSLSTLNLLANPfncnchlawlgewlrkkrivtgnprcqspyfLKEIPiqdvavqdfaceegndenscSP 706
Cdd:COG4886    127 DL-PEELANLTNLKELDLSNNQ-------------------------------LTDLP--------------------EP 154

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  707 LARCPAecscLdTVVRCSNKGLKVLPKGIPR--DVTELYLDGNEFTQVPLELSNYKHLTLIDLSNNQISTLSNhSFSNMS 784
Cdd:COG4886    155 LGNLTN----L-KSLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLT 228

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  785 ELLTLILSYNRLRCIPakAFDGLKSLRLLSLHGNDIAVIPDGAfkDLSSLSHLALGANPL 844
Cdd:COG4886    229 NLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-407 4.28e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 4.28e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   45 NIPRNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKissiergAFQDLQELERLRLNRNNLQVLPELLFlGTTKLFR 124
Cdd:COG4886     69 LSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEELA-NLTNLKE 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  125 LDLSENQIQGIPrKAFRGSTEIKNLQLDYNQISCIeDGAFRALRDLEVLTLNNNNISRLSvASFNHMPKLRTFRLHSNNl 204
Cdd:COG4886    141 LDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ- 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  205 lcdcnvawlsdwlrqrprlglytqcmappslrghniaevqkkefmctgpqshsscsvlqcpelctcsnnvvdcrgkgLTE 284
Cdd:COG4886    217 -----------------------------------------------------------------------------LTD 219

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  285 IPTNLPE--TITEIRLEQNSIKIIPagAFAPYKRLRRIDLSNNQITELasDSFQGLRSLNSLVLYGNKITELPKGLFDGL 362
Cdd:COG4886    220 LPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELELL 295

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1207106434  363 FSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKGTF 407
Cdd:COG4886    296 LGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTL 340
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-434 4.87e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.78  E-value: 4.87e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   49 NVERLDLNANNltkitkaDFAGLKNLRVLQLMENKISSIERgAFQDLQELERLRLNRNNLQVLPELLFlGTTKLFRLDLS 128
Cdd:COG4886     97 NLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLS 167

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  129 ENQIQGIPrKAFRGSTEIKNLQLDYNQISCIEDgAFRALRDLEVLTLNNNNISRLSvASFNHMPKLRTFRLHSNNLlcdc 208
Cdd:COG4886    168 NNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQL---- 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  209 nvawlSDWlrqrprlglytqcmappslrghniaevqkkefmctgpqshsscsvlqcPELCTCSNnvvdcrgkglteiptn 288
Cdd:COG4886    241 -----TDL------------------------------------------------PELGNLTN---------------- 251

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  289 lpetITEIRLEQNSIKIIPAGAFAPykRLRRIDLSNNQITELASDSFQGLRSLNSLVLYGNKITELPkgLFDGLFSLQLL 368
Cdd:COG4886    252 ----LEELDLSNNQLTDLPPLANLT--NLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE--LLILLLLLTTL 323

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434  369 LLNANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRAIQTLHLAQNPFMCDCHLKWLAD 434
Cdd:COG4886    324 LLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
522-820 3.30e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.00  E-value: 3.30e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  522 RLNNNEFTVLEATGIFKKLPQLRKINLSNNKITDIEEGtfegasgvneliltsnrlegvhysmLKGLGGLRTLMLRSNRI 601
Cdd:COG4886     94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEE-------------------------LANLTNLKELDLSNNQL 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  602 SCVNNgSFTGLSSVRLLSLYDNLITSMsPGAFDTLHSLSTLNLlanpfncnchlawlgewlrkkrivTGNPrcqspyfLK 681
Cdd:COG4886    149 TDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDL------------------------SNNQ-------IT 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  682 EIPiqdvavqdfaceegndenscSPLARCPAecscldtvvrcsnkglkvlpkgiprdVTELYLDGNEFTQVPLELSNYKH 761
Cdd:COG4886    196 DLP--------------------EPLGNLTN--------------------------LEELDLSGNQLTDLPEPLANLTN 229

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434  762 LTLIDLSNNQISTLSnhSFSNMSELLTLILSYNRLRCIPAKAfdGLKSLRLLSLHGNDI 820
Cdd:COG4886    230 LETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
Laminin_G_1 pfam00054
Laminin G domain;
1191-1322 2.31e-19

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 85.45  E-value: 2.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434 1191 IATDEDNGVLLYKGDNEH---IAVELYRGRLRVSYDSGSYPPSaIYSVETINDGSFHVVELVAKDQSLSLSIDGGSPKSI 1267
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYDLGSGAAV-VRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434 1268 NT-ANSPSPVPSPAPLYLGGLPQQSGLASLrqgsGRNGSSFHGCIRNLYINDQLQD 1322
Cdd:pfam00054   80 ESpLGATTDLDVDGPLYVGGLPSLGVKKRR----LAISPSFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
498-649 1.01e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 1.01e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  498 TTVDCSGQKLTKIPDHIPQYTA--ELRLNNNEFTVLEATgiFKKLPQLRKINLSNNKITDIEEGtFEGASGVNELILTSN 575
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANLTNlkELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNN 192

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207106434  576 RLEGVHYSmLKGLGGLRTLMLRSNRISCVNNgSFTGLSSVRLLSLYDNLITSMSpgAFDTLHSLSTLNLLANPF 649
Cdd:COG4886    193 QITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
498-649 1.28e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.30  E-value: 1.28e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  498 TTVDCSGQKLTKIPDHIPQYTA--ELRLNNNEFTVLEATgiFKKLPQLRKINLSNNKITDIEEgTFEGASGVNELILTSN 575
Cdd:COG4886    139 KELDLSNNQLTDLPEPLGNLTNlkSLDLSNNQLTDLPEE--LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGN 215

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207106434  576 RLEGVHYSmLKGLGGLRTLMLRSNRISCVnnGSFTGLSSVRLLSLYDNLITSMSPGAfdTLHSLSTLNLLANPF 649
Cdd:COG4886    216 QLTDLPEP-LANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
310-650 1.49e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 1.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  310 AFAPYKRLRRIDLSNNQITELaSDSFQGLRSLNSLVLYGNKITELPKGLFdglfslqllllnankinclrvdsfqDLQNL 389
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-------------------------NLTNL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  390 NLLSLYDNKLQTIAKgtfsslrAIQTLHlaqnpfmcdcHLKWLadYLQDNPIETsgarctsprrlANKRIGQIKskkfrc 469
Cdd:COG4886    162 KSLDLSNNQLTDLPE-------ELGNLT----------NLKEL--DLSNNQITD-----------LPEPLGNLT------ 205

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  470 sgvedyrsKLggdcfadlacpekcrcegTTVDCSGQKLTKIPDHIPQYTA--ELRLNNNEFTVLEAtgiFKKLPQLRKIN 547
Cdd:COG4886    206 --------NL------------------EELDLSGNQLTDLPEPLANLTNleTLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  548 LSNNKITDIEEgtfegasgvneliltsnrlegvhysmLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITS 627
Cdd:COG4886    257 LSNNQLTDLPP--------------------------LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310

                          330       340
                   ....*....|....*....|...
gi 1207106434  628 MSPGAFDTLHSLSTLNLLANPFN 650
Cdd:COG4886    311 LELLILLLLLTTLLLLLLLLKGL 333
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
274-443 4.38e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 4.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  274 VVDCRGKGLTEIPTNLPE--TITEIRLEQNSIKIIPAgAFAPYKRLRRIDLSNNQITELaSDSFQGLRSLNSLVLYGNKI 351
Cdd:COG4886    140 ELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQL 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  352 TELPkglfdglfslqllllnankinclrvDSFQDLQNLNLLSLYDNKLQTIAKgtFSSLRAIQTLHLAQN-----PFMCD 426
Cdd:COG4886    218 TDLP-------------------------EPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNqltdlPPLAN 270

                          170
                   ....*....|....*...
gi 1207106434  427 CH-LKWLadYLQDNPIET 443
Cdd:COG4886    271 LTnLKTL--DLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
293-663 7.71e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 7.71e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  293 ITEIRLEQNSIKIIPAgAFAPYKRLRRIDLSNNQITELaSDSFQGLRSLNSLVLYGNKITELPKglfdglfslqllllna 372
Cdd:COG4886    115 LESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE---------------- 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  373 nkinclrvdSFQDLQNLNLLSLYDNKLQTIAKgTFSSLRAIQTLHLAQNPfmcdchlkwladyLQDNPIEtsgarctspr 452
Cdd:COG4886    177 ---------ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQ-------------LTDLPEP---------- 223

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  453 rlankrIGQIKskkfrcsgvedyrsKLggdcfadlacpekcrcegTTVDCSGQKLTKIPD--HIPQYTaELRLNNNEFTV 530
Cdd:COG4886    224 ------LANLT--------------NL------------------ETLDLSNNQLTDLPElgNLTNLE-ELDLSNNQLTD 264

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  531 LEATGifkKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEGVhySMLKGLGGLRTLMLRSNRISCVNNGSFT 610
Cdd:COG4886    265 LPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL--ELLILLLLLTTLLLLLLLLKGLLVTLTT 339

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207106434  611 GLSSVRLLSLYDNLITSMSPGAFDTLHSLSTLNLLANPFNCNCHLAWLGEWLR 663
Cdd:COG4886    340 LALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR_8 pfam13855
Leucine rich repeat;
761-820 2.32e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 71.79  E-value: 2.32e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  761 HLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLKSLRLLSLHGNDI 820
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
282-650 4.99e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.21  E-value: 4.99e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  282 LTEIPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGLRSLNSLVLYGNKITELPKGLFDG 361
Cdd:COG4886      8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  362 LFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKgTFSSLRAIQTLHLAQNPfmcdchlkwladyLQDNPI 441
Cdd:COG4886     88 GLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQ-------------LTDLPE 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  442 EtsgarctsprrlankrIGQIKskkfrcsgvedyrsKLggdcfadlacpekcrcegTTVDCSGQKLTKIPDHIPQYTA-- 519
Cdd:COG4886    154 P----------------LGNLT--------------NL------------------KSLDLSNNQLTDLPEELGNLTNlk 185

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  520 ELRLNNNEFTVLEATgiFKKLPQLRKINLSNNKITDIEEgTFEGASGVNELILTSNRLEGVhySMLKGLGGLRTLMLRSN 599
Cdd:COG4886    186 ELDLSNNQITDLPEP--LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNN 260

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  600 RISCVNNGSftGLSSVRLLSLYDNLITSMSPGAFDTLHSLSTLNLLANPFN 650
Cdd:COG4886    261 QLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
LRR_8 pfam13855
Leucine rich repeat;
48-108 2.48e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 66.01  E-value: 2.48e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNL 108
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
590-649 1.45e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.70  E-value: 1.45e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  590 GLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSLSTLNLLANPF 649
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 53-207 7.82e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 7.82e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   53 LDLNANNLTKITkaDFAGLKNLRVLQLMENKISSIErgAFQDLQELERLRLNRNNLQVLPELLFLgtTKLFRLDLSENQI 132
Cdd:cd21340      7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENLENL--VNLKKLYLGGNRI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  133 QGIprKAFRGSTEIKNLQLDYNQIS-----CIEDGAFRALRD-LEVLTLNNNNISrlSVASFNHMPKLRTFRLhSNNLLC 206
Cdd:cd21340     81 SVV--EGLENLTNLEELHIENQRLPpgeklTFDPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDA-SNNQIS 155


                   .
gi 1207106434  207 D 207
Cdd:cd21340    156 D 156
LRR_8 pfam13855
Leucine rich repeat;
144-204 1.90e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.90e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  144 TEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNL 204
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
541-601 1.90e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.90e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  541 PQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEGVHYSMLKGLGGLRTLMLRSNRI 601
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
73-132 1.16e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 1.16e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   73 NLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQVLPELLFLGTTKLFRLDLSENQI 132
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
565-625 1.19e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 1.19e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  565 SGVNELILTSNRLEGVHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLI 625
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
96-156 1.76e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 1.76e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434   96 QELERLRLNRNNLQVLPELLFLGTTKLFRLDLSENQIQGIPRKAFRGSTEIKNLQLDYNQI 156
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-204 2.43e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 2.43e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNN-LQVLPEllFLGTTKLFRLD 126
Cdd:PLN00113   404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPD--SFGSKRLENLD 481

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434  127 LSENQIQG-IPRKaFRGSTEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNL 204
Cdd:PLN00113   482 LSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
784-844 5.59e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 56.38  E-value: 5.59e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  784 SELLTLILSYNRLRCIPAKAFDGLKSLRLLSLHGNDIAVIPDGAFKDLSSLSHLALGANPL 844
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
520-577 7.28e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.99  E-value: 7.28e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207106434  520 ELRLNNNEFTVLEAtGIFKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRL 577
Cdd:pfam13855    5 SLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
120-180 1.15e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.61  E-value: 1.15e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  120 TKLFRLDLSENQIQGIPRKAFRGSTEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNI 180
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 620-697 1.87e-09

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 62.79  E-value: 1.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  620 LYDNLITSMSPGAFDTLHSLSTLNLLANPFNCNCHLAWLGEWLRKKRIVTGNPR---CQSPYFLKEIPIQDVAVQDFACE 696
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   .
gi 1207106434  697 E 697
Cdd:TIGR00864   82 E 82
LRR_8 pfam13855
Leucine rich repeat;
739-796 2.09e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.84  E-value: 2.09e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434  739 VTELYLDGNEFTQVPLE-LSNYKHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRL 796
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
294-351 2.62e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 2.62e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207106434  294 TEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGLRSLNSLVLYGNKI 351
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
371-423 1.33e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 1.33e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207106434  371 NANKINCLRVDSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRAIQTLHLAQNPF 423
Cdd:pfam13855    9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
679-844 2.34e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.94  E-value: 2.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  679 FLKEIPIQDVAVQDFACEEGNDenscsplarcpaecsCL---DTVVRCSNKGLKVLPKGIPRDVTELYLDGNEFTQVPLE 755
Cdd:PRK15370   153 WVKEAPAKEAANREEAVQRMRD---------------CLknnKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEN 217

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  756 L-SNYKHLT------------------LIDLSNNQISTLSNHSfsnMSELLTLILSYNRLRCIPAKAFDGlksLRLLSLH 816
Cdd:PRK15370   218 LqGNIKTLYansnqltsipatlpdtiqEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEE---LRYLSVY 291

                          170       180
                   ....*....|....*....|....*...
gi 1207106434  817 GNDIAVIPDGAfkdLSSLSHLALGANPL 844
Cdd:PRK15370   292 DNSIRTLPAHL---PSGITHLNVQSNSL 316
LRR_8 pfam13855
Leucine rich repeat;
316-361 2.57e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 2.57e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1207106434  316 RLRRIDLSNNQITELASDSFQGLRSLNSLVLYGNKITELPKGLFDG 361
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1079-1115 1.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.27e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207106434 1079 DFDDCED-NKCKNGAQCIDAVNGYTCVCPEGYSGLFCE 1115
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-399 2.15e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 2.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSIERGAFQDLQELERLRLNRNNLQ-VLPELLFlGTTKLFRLD 126
Cdd:PLN00113   212 KSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-SLQKLISLD 290

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  127 LSENQIQG-IPRKAFR-GSTEIknLQLDYNQISCIEDGAFRALRDLEVLTLNNNNISRLSVASFNHMPKLRTFRLHSNNL 204
Cdd:PLN00113   291 LSDNSLSGeIPELVIQlQNLEI--LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  205 -------LCDCNvawlsdwlrqrprlGLYTQCMAPPSLRGhniaEVqkkefmctgPQSHSSCSVLQCPELCtcSNNVVDC 277
Cdd:PLN00113   369 tgeipegLCSSG--------------NLFKLILFSNSLEG----EI---------PKSLGACRSLRRVRLQ--DNSFSGE 419

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  278 RGKGLTEIP---------TNLPETITEIRLEQNSIKIIPAGA---------FAPYKRLRRIDLSNNQITELASDSFQGLR 339
Cdd:PLN00113   420 LPSEFTKLPlvyfldisnNNLQGRINSRKWDMPSLQMLSLARnkffgglpdSFGSKRLENLDLSRNQFSGAVPRKLGSLS 499

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  340 SLNSLVLYGNKIT-ELPKGLfDGLFSLQLLLLNANKINCLRVDSFQDLQNLNLLSLYDNKL 399
Cdd:PLN00113   500 ELMQLKLSENKLSgEIPDEL-SSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
39-419 2.53e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.47  E-value: 2.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   39 LRSVPRNIPRNVERLDLNANNLTKITKADFAglkNLRVLQLMENKISSIERGAFQDLQELErlrLNRNNLQVLPELLflg 118
Cdd:PRK15370   190 LTTIPACIPEQITTLILDNNELKSLPENLQG---NIKTLYANSNQLTSIPATLPDTIQEME---LSINRITELPERL--- 260

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  119 ttklfrldlsenqiqgiprkafrgSTEIKNLQLDYNQISCIEDGAFRALRDLEVLtlnNNNISRLSvasfNHMPK-LRTF 197
Cdd:PRK15370   261 ------------------------PSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIRTLP----AHLPSgITHL 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  198 RLHSNNLlcdcnvAWLSDWLrqrprlglytqcmaPPSLRghnIAEVQKKEFMCTgPQSHSscsvlqcPELctcsnNVVDC 277
Cdd:PRK15370   310 NVQSNSL------TALPETL--------------PPGLK---TLEAGENALTSL-PASLP-------PEL-----QVLDV 353

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  278 RGKGLTEIPTNLPETITEIRLEQNSIKIIPAGAFAPykrLRRIDLSNNQITELASD--SF--QGLRSLNSLVLYgNKITE 353
Cdd:PRK15370   354 SKNQITVLPETLPPTITTLDVSRNALTNLPENLPAA---LQIMQASRNNLVRLPESlpHFrgEGPQPTRIIVEY-NPFSE 429

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434  354 lpkglfdglfslqllllnankinclrvDSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRAIQTLHLA 419
Cdd:PRK15370   430 ---------------------------RTIQNMQRLMSSVGYQGPRVLFAMGDFSIVRVTRPLHQA 468
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 815-1007 5.11e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 54.70  E-value: 5.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  815 LHGNDIAVIPDGAFKDLSSLSHLALGANPLYCDCHMQWLSDWVKSG---YKEPGIARCTGPGDMTDKLLLTTPSKKFTCt 891
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvkVRQPEAALCAGPGALAGQPLLGIPLLDSGC- 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  892 evpgtcgfpvpgpvDVSILAkcnpCLSNPCKNDGTCSNHPVDFYRCTcPYGFKGQDCEEpihACISnpcqnggTCHLKDG 971
Cdd:TIGR00864   81 --------------DEEYVA----CLKDNSSGGGAARSELVIFSAAH-EGLFQPEACNA---FCFS-------AGHGLAA 131

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1207106434  972 EENTHWCVCPEGFEGDECEINIDDCEDNDCENNSTC 1007
Cdd:TIGR00864  132 LGEQGECLCGAAQPSEANFACESLCSGPPPPPAAAC 167
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 28-223 6.53e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.13  E-value: 6.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   28 SGTAVDCHGQSLRSVPrniprNVERLDLNANNLTKITKADFAGL---KNLRVLQLMENKIS-SIER---GAFQDLQE-LE 99
Cdd:cd00116     66 IPRGLQSLLQGLTKGC-----GLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGdRGLRllaKGLKDLPPaLE 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  100 RLRLNRNNLQVLP----ELLFLGTTKLFRLDLSENQI--QGIPR--KAFRGSTEIKNLQLDYNQISCIED----GAFRAL 167
Cdd:cd00116    141 KLVLGRNRLEGAScealAKALRANRDLKELNLANNGIgdAGIRAlaEGLKANCNLEVLDLNNNGLTDEGAsalaETLASL 220

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207106434  168 RDLEVLTLNNNNI-----SRLSVASFNHMPKLRTFRLhSNNLLCDCNVAWLSDWLRQRPRL 223
Cdd:cd00116    221 KSLEVLNLGDNNLtdagaAALASALLSPNISLLTLSL-SCNDITDDGAKDLAEVLAEKESL 280
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 737-837 7.29e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 7.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  737 RDVTELYLDGNEFTQVPlELSNYKHLTLIDLSNNQISTLSNhsFSNMSELLTLILSYNRLRCIPAkaFDGLKSLRLLSLH 816
Cdd:cd21340      2 KRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLG 76

                           90       100
                   ....*....|....*....|.
gi 1207106434  817 GNDIAVIpDGaFKDLSSLSHL 837
Cdd:cd21340     77 GNRISVV-EG-LENLTNLEEL 95
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
38-183 1.23e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.16  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   38 SLRSVPRNIPRNVERLDLNANNLTKI--TKADfaglkNLRVLQLMENKISSI-ER--GAFQDL---------------QE 97
Cdd:PRK15370   210 ELKSLPENLQGNIKTLYANSNQLTSIpaTLPD-----TIQEMELSINRITELpERlpSALQSLdlfhnkisclpenlpEE 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   98 LERLRLNRNNLQVLPELLFLGTTKLFrldLSENQIQGIPRKAFRGsteIKNLQLDYNQISCIEDGAFRALRDLEVltlNN 177
Cdd:PRK15370   285 LRYLSVYDNSIRTLPAHLPSGITHLN---VQSNSLTALPETLPPG---LKTLEAGENALTSLPASLPPELQVLDV---SK 355


                   ....*.
gi 1207106434  178 NNISRL 183
Cdd:PRK15370   356 NQITVL 361
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 175-237 2.87e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 2.87e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434  175 LNNNNISRLSVASFNHMPKLRTFRLHSNNLLCDCNVAWLSDWLRQ---RPRLGLYTQCMAPPSLRG 237
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEkgvKVRQPEAALCAGPGALAG 67
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 293-828 3.01e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 52.16  E-value: 3.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  293 ITEIRLEQNSI--KIIPAGAFAPYkrLRRIDLSNNQIT-ELASDSFQGLRSLNSLVLYGNKIT-ELPKGLFDGLFSLQLL 368
Cdd:PLN00113    71 VVSIDLSGKNIsgKISSAIFRLPY--IQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS 148

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  369 LlnankiNCLRVDSFQDL---QNLNLLSLYDNKLQTIAKGTFSSLRAIQTLHLAQNPFMCDC--------HLKWLadYLQ 437
Cdd:PLN00113   149 N------NMLSGEIPNDIgsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIprelgqmkSLKWI--YLG 220

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  438 DN----PIETSGARCTSPRRL---ANKRIGQIKSKKFRCSGVED---YRSKLGGDCFADLACPEKCrcegTTVDCSGQKL 507
Cdd:PLN00113   221 YNnlsgEIPYEIGGLTSLNHLdlvYNNLTGPIPSSLGNLKNLQYlflYQNKLSGPIPPSIFSLQKL----ISLDLSDNSL 296

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  508 T-KIPDHIPQY-TAE-LRLNNNEFTVLEATGIfKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRLEGVHYSM 584
Cdd:PLN00113   297 SgEIPELVIQLqNLEiLHLFSNNFTGKIPVAL-TSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEG 375

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  585 LKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSLSTLNLLANPFNCNCHlawlgewlrk 664
Cdd:PLN00113   376 LCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRIN---------- 445

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  665 krivtgnprcQSPYFLKEIPIQDVAVQDFACEEGNDENScsplarcpaecSCLDTVVRCSNKGLKVLPKGIPR--DVTEL 742
Cdd:PLN00113   446 ----------SRKWDMPSLQMLSLARNKFFGGLPDSFGS-----------KRLENLDLSRNQFSGAVPRKLGSlsELMQL 504

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  743 YLDGNEFT-QVPLELSNYKHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLKSLRLLSLHGNDI- 820
Cdd:PLN00113   505 KLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHLh 584


                   ....*....
gi 1207106434  821 -AVIPDGAF 828
Cdd:PLN00113   585 gSLPSTGAF 593
EGF_CA smart00179
Calcium-binding EGF-like domain;
1079-1115 3.06e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.06e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1207106434  1079 DFDDCE-DNKCKNGAQCIDAVNGYTCVCPEGYS-GLFCE 1115
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN03150 PLN03150
hypothetical protein; Provisional
 751-845 3.24e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 3.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  751 QVPLELSNYKHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLR-CIPAkAFDGLKSLRLLSLHGNdiavipdgafk 829
Cdd:PLN03150   433 FIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIPE-SLGQLTSLRILNLNGN----------- 500

                           90
                   ....*....|....*.
gi 1207106434  830 DLSSLSHLALGANPLY 845
Cdd:PLN03150   501 SLSGRVPAALGGRLLH 516
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
281-410 4.14e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 4.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  281 GLTEIPTNLPETITEIRLEQNSIKIIPAGAFAPYKRLRridLSNNQITELAS---DSFQGLRslnslvLYGNKITELPKG 357
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLY---ANSNQLTSIPAtlpDTIQEME------LSINRITELPER 259

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1207106434  358 LfdgLFSLQLLLLNANKINCLRvDSFQDlqNLNLLSLYDNKLQTIAKGTFSSL 410
Cdd:PRK15370   260 L---PSALQSLDLFHNKISCLP-ENLPE--ELRYLSVYDNSIRTLPAHLPSGI 306
LRRNT smart00013
Leucine rich repeat N-terminal domain;
710-741 8.37e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.85  E-value: 8.37e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1207106434   710 CPAECSCLDTVVRCSNKGLKVLPKGIPRDVTE 741
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 719-815 9.04e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 9.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  719 TVVRCSNKGLKVLPK-GIPRDVTELYLDGNEFTQVPlELSNYKHLTLIDLSNNQISTLSNhsFSNMSELLTLILSYNRLR 797
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                           90
                   ....*....|....*...
gi 1207106434  798 CIpaKAFDGLKSLRLLSL 815
Cdd:cd21340     82 VV--EGLENLTNLEELHI 97
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 506-649 9.20e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 9.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  506 KLTKIP--DHIPQYTaELRLNNNEFTVLEAtgiFKKLPQLRKINLSNNKITDIeEGtFEGASGVNELILTSNRLEG---- 579
Cdd:cd21340     35 KITKIEnlEFLTNLT-HLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPgekl 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207106434  580 -VHYSMLKGLGG-LRTLMLRSNRISCVNngSFTGLSSVRLLSLYDNLITSMSP--GAFDTLHSLSTLNLLANPF 649
Cdd:cd21340    109 tFDPRSLAALSNsLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1083-1111 1.46e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.14  E-value: 1.46e-05
                           10        20
                   ....*....|....*....|....*....
gi 1207106434 1083 CEDNKCKNGAQCIDAVNGYTCVCPEGYSG 1111
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
LRRCT smart00082
Leucine rich repeat C-terminal domain;
842-891 1.46e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.57  E-value: 1.46e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1207106434   842 NPLYCDCHMQWLSDWV--KSGYKEPGIARCTGPGDMTDKLLLTTPSkKFTCT 891
Cdd:smart00082    1 NPFICDCELRWLLRWLqaNEHLQDPVDLRCASPSSLRGPLLELLHS-EFKCP 51
LRRCT smart00082
Leucine rich repeat C-terminal domain;
647-677 2.12e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 43.19  E-value: 2.12e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207106434   647 NPFNCNCHLAWLGEWLRKKRIV--TGNPRCQSP 677
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASP 33
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1470-1531 2.16e-05

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 44.32  E-value: 2.16e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207106434  1470 YAACQStEKVSRLECRGSCGDGT-----------SCCAPLRSKRRKYTFQCTDGSSFVQEVEKVVKCGCT-KCP 1531
Cdd:smart00041   10 YNGCTS-VTVKNAFCEGKCGSASsysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEpNCP 82
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 394-457 2.29e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.31  E-value: 2.29e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207106434  394 LYDNKLQTIAKGTFSSLRAIQTLHLAQNPFMCDCHLKWLADYLQDNPIET---SGARCTSPRRLANK 457
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-51 2.34e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.34e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1207106434    21 CPSQCSCSGTAVDCHGQSLRSVPRNIPRNVE 51
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT smart00013
Leucine rich repeat N-terminal domain;
263-295 2.51e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.69  E-value: 2.51e-05
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207106434   263 QCPELCTCSNNVVDCRGKGLTEIPTNLPETITE 295
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
488-518 3.51e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.92  E-value: 3.51e-05
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1207106434   488 ACPEKCRCEGTTVDCSGQKLTKIPDHIPQYT 518
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 46-204 4.32e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.86  E-value: 4.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   46 IPRNVERLDLNANNLTK-----ITKAdFAGLKNLRVLQLMENKISsiERGA---FQDLQE---LERLRLNRNNLQV---- 110
Cdd:COG5238    206 QNTTVTTLWLKRNPIGDegaeiLAEA-LKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIGAegai 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  111 -LPELLfLGTTKLFRLDLSENQIQGIPRKAF----RGSTEIKNLQLDYNQISciEDGA---FRAL---RDLEVLTLNNNN 179
Cdd:COG5238    283 aLAKAL-QGNTTLTSLDLSVNRIGDEGAIALaeglQGNKTLHTLNLAYNGIG--AQGAialAKALqenTTLHSLDLSDNQ 359

                          170       180
                   ....*....|....*....|....*....
gi 1207106434  180 ISRLSVASFNHMPK----LRTFRLHSNNL 204
Cdd:COG5238    360 IGDEGAIALAKYLEgnttLRELNLGKNNI 388
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1041-1077 4.71e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 41.85  E-value: 4.71e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207106434 1041 DFCASElNLCQHDSKCILTAKGFMCECTPGYTGEHCE 1077
Cdd:cd00054      3 DECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-358 7.08e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 7.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   48 RNVERLDLNANNLTKITKADFAGLKNLRVLQLMENKISSierGAFQDL---QELERLRLNRNNLQ-VLPELLfLGTTKLF 123
Cdd:PLN00113   308 QNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSG---EIPKNLgkhNNLTVLDLSTNNLTgEIPEGL-CSSGNLF 383

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  124 RLDLSENQIQGIPRKAFRGSTEIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNIS-RLSVASFNhMPKLRTFRLHSN 202
Cdd:PLN00113   384 KLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKWD-MPSLQMLSLARN 462

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  203 NLLCdcnvawlsdwlrqrprlGLytqcmaPPSLRGHNIA--EVQKKEFMCTGPQSHSScsvlqcpelctcsnnvvdcrgk 280
Cdd:PLN00113   463 KFFG-----------------GL------PDSFGSKRLEnlDLSRNQFSGAVPRKLGS---------------------- 497

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207106434  281 glteiptnLPEtITEIRLEQNSIKIIPAGAFAPYKRLRRIDLSNNQITELASDSFQGLRSLNSLVLYGNKIT-ELPKGL 358
Cdd:PLN00113   498 --------LSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNL 567
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 500-844 7.20e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 7.20e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  500 VDCSGQKLT-KIPDHIPQYTAE--LRLNNNEFTvleaTGIFKKLPQLRK---INLSNNKITDIEEGTFEGASGVNELILT 573
Cdd:PLN00113   169 LDLGGNVLVgKIPNSLTNLTSLefLTLASNQLV----GQIPRELGQMKSlkwIYLGYNNLSGEIPYEIGGLTSLNHLDLV 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  574 SNRLEGVHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSLSTLNLLANPFNCNC 653
Cdd:PLN00113   245 YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKI 324

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  654 HLAwlgewlrkkriVTGNPRCQ-----SPYFLKEIPI-----QDVAVQDFA------------CEEGN------DENSC- 704
Cdd:PLN00113   325 PVA-----------LTSLPRLQvlqlwSNKFSGEIPKnlgkhNNLTVLDLStnnltgeipeglCSSGNlfklilFSNSLe 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  705 SPLARCPAECSCLDTVVRCSNKGLKVLPKGIPR-------DVTELYLDGN------EFTQVPL-------------ELSN 758
Cdd:PLN00113   394 GEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKlplvyflDISNNNLQGRinsrkwDMPSLQMlslarnkffgglpDSFG 473

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  759 YKHLTLIDLSNNQISTLSNHSFSNMSELLTLILSYNRLRCIPAKAFDGLKSLRLLSL-HGNDIAVIPDGaFKDLSSLSHL 837
Cdd:PLN00113   474 SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLsHNQLSGQIPAS-FSEMPVLSQL 552


                   ....*..
gi 1207106434  838 ALGANPL 844
Cdd:PLN00113   553 DLSQNQL 559
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 498-844 1.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.21e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  498 TTVDCSGQ----KLTKIPDHIPqYTAELRLNNNEFTVLEATGIFKKLPQLRKINLSNNKIT-DIEEGTfegASGVNELIL 572
Cdd:PLN00113    72 VSIDLSGKnisgKISSAIFRLP-YIQTINLSNNQLSGPIPDDIFTTSSSLRYLNLSNNNFTgSIPRGS---IPNLETLDL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  573 TSNRLEGVHYSMLKGLGGLRTLMLRSNRISCVNNGSFTGLSSVRLLSLYDNLITSMSPGAFDTLHSLSTLNLLANpfNCN 652
Cdd:PLN00113   148 SNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYN--NLS 225

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  653 CHLAW-LGEW--LRKKRIVTGNPRCQSP-----------YFLKE------IPIQDVAVQDFACEEGNDENSCSPLARCPA 712
Cdd:PLN00113   226 GEIPYeIGGLtsLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  713 ECSCLDTVVRCSNKGLKVLPKGI---PRdVTELYLDGNEFT-QVPLELSNYKHLTLIDLSNNQISTLSNHSFSNMSELLT 788
Cdd:PLN00113   306 QLQNLEILHLFSNNFTGKIPVALtslPR-LQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFK 384

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207106434  789 LILSYNRLRCIPAKAFDGLKSLRLLSLHGNDIAVIPDGAFKDLSSLSHLALGANPL 844
Cdd:PLN00113   385 LILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 47-183 1.48e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 1.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   47 PRNVERLDLNANNLTK-----ITKAdFAGLKNLRVLQLMENKISsiERGAF---QDLQE---LERLRLNRNNLQV----- 110
Cdd:COG5238    263 NTTVETLYLSGNQIGAegaiaLAKA-LQGNTTLTSLDLSVNRIG--DEGAIalaEGLQGnktLHTLNLAYNGIGAqgaia 339

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207106434  111 LPELLFLGTTkLFRLDLSENQIQGIPRKAF----RGSTEIKNLQLDYNQISciEDGAfRALRDLevltLNNNNISRL 183
Cdd:COG5238    340 LAKALQENTT-LHSLDLSDNQIGDEGAIALakylEGNTTLRELNLGKNNIG--KQGA-EALIDA----LQTNRLHTL 408
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 914-949 1.96e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 1.96e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207106434  914 NPCLS-NPCKNDGTCSNHPVDfYRCTCPYGFKGQDCE 949
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGS-YRCSCPPGYTGRNCE 38
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 279-424 2.47e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 2.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  279 GKGLTEIPT-NLPETITEIRLEQNSIKIIPAGAFAPykRLRRIDLSNNQITELasDSFQGLRSLNSLVLYGNKITE---- 353
Cdd:cd21340     11 DKNITKIDNlSLCKNLKVLYLYDNKITKIENLEFLT--NLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVvegl 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  354 ---------------LPKG---LFDGLFSLQLLllnankiNCLRV-----------DSFQDLQNLNLLSLYDNKLQTIA- 403
Cdd:cd21340     87 enltnleelhienqrLPPGeklTFDPRSLAALS-------NSLRVlnisgnnidslEPLAPLRNLEQLDASNNQISDLEe 159

                          170       180
                   ....*....|....*....|..
gi 1207106434  404 -KGTFSSLRAIQTLHLAQNPFM 424
Cdd:cd21340    160 lLDLLSSWPSLRELDLTGNPVC 181
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1088-1109 2.49e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.62  E-value: 2.49e-04
                           10        20
                   ....*....|....*....|..
gi 1207106434 1088 CKNGAQCIDAVNGYTCVCPEGY 1109
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
32-156 2.59e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 2.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434   32 VDCHGQSLRSVPRNIPRNVERLDLNANNLTKITKADFAGLKnlrVLQLMENKISSIERGAFQDLQELErlrLNRNNLQVL 111
Cdd:PRK15370   288 LSVYDNSIRTLPAHLPSGITHLNVQSNSLTALPETLPPGLK---TLEAGENALTSLPASLPPELQVLD---VSKNQITVL 361

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1207106434  112 PELLflgTTKLFRLDLSENQIQGIPRKAfrgSTEIKNLQLDYNQI 156
Cdd:PRK15370   362 PETL---PPTITTLDVSRNALTNLPENL---PAALQIMQASRNNL 400
EGF_CA smart00179
Calcium-binding EGF-like domain;
992-1023 2.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 2.72e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207106434   992 NIDDCE-DNDCENNSTCVDGINNYTCLCSPEYT 1023
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 170-207 2.97e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.97e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1207106434  170 LEVLTLNNNNISRLSvaSFNHMPKLRTFRLHSNNLLCD 207
Cdd:pfam12799    3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITD 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
421-451 3.17e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 40.11  E-value: 3.17e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1207106434   421 NPFMCDCHLKWLADYLQDNPI--ETSGARCTSP 451
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 992-1023 3.53e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 3.53e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207106434  992 NIDDCED-NDCENNSTCVDGINNYTCLCSPEYT 1023
Cdd:cd00054      1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYT 33
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 263-290 3.64e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.15  E-value: 3.64e-04
                           10        20
                   ....*....|....*....|....*...
gi 1207106434  263 QCPELCTCSNNVVDCRGKGLTEIPTNLP 290
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 710-736 4.26e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.76  E-value: 4.26e-04
                           10        20
                   ....*....|....*....|....*..
gi 1207106434  710 CPAECSCLDTVVRCSNKGLKVLPKGIP 736
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-47 4.35e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.76  E-value: 4.35e-04
                           10        20
                   ....*....|....*....|....*..
gi 1207106434   21 CPSQCSCSGTAVDCHGQSLRSVPRNIP 47
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1084-1111 6.42e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 38.61  E-value: 6.42e-04
                           10        20
                   ....*....|....*....|....*...
gi 1207106434 1084 EDNKCKNGAQCIDAVNGYTCVCPEGYSG 1111
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 315-355 8.03e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 8.03e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1207106434  315 KRLRRIDLSNNQITELasDSFQGLRSLNSLVLYGN-KITELP 355
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 72-137 9.48e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 9.48e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207106434   72 KNLRVLQLMENKISSIErgAFQDLQELERLRLNRNNLQVLPEL--LFLGTTKLFRLDLSENQIQGIPR 137
Cdd:cd21340    120 NSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPVCKKPK 185
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 520-558 1.35e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.00  E-value: 1.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1207106434  520 ELRLNNNEFTVLEAtgiFKKLPQLRKINLS-NNKITDIEE 558
Cdd:pfam12799    5 VLDLSNNQITDIPP---LAKLPNLETLDLSgNNKITDLSD 41
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
254-355 1.47e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 43.23  E-value: 1.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  254 QSHSSCSVLQCPELCTCSNNVVDCRGK-GLTEIPTNLPETITEIRLEQNSIKIIPagAFAPykRLRRIDLSNNQITELA- 331
Cdd:PRK15387   184 ESRGRAAVVQKMRACLNNGNAVLNVGEsGLTTLPDCLPAHITTLVIPDNNLTSLP--ALPP--ELRTLEVSGNQLTSLPv 259

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1207106434  332 -----------SDSFQGLRSLNS----LVLYGNKITELP 355
Cdd:PRK15387   260 lppgllelsifSNPLTHLPALPSglckLWIFGNQLTSLP 298
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 488-515 1.50e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 37.22  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....*...
gi 1207106434  488 ACPEKCRCEGTTVDCSGQKLTKIPDHIP 515
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 381-626 1.84e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  381 DSFQDLQNLNLLSLYDNKLQTIAKGTFSSLRAIQTL---HLAQNPfMCDCHLKWLADYLQDNPIetsgarctsprrlank 457
Cdd:cd00116     75 QGLTKGCGLQELDLSDNALGPDGCGVLESLLRSSSLqelKLNNNG-LGDRGLRLLAKGLKDLPP---------------- 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  458 rigqiKSKKFRCSgvedyRSKLGGDCFADLA--CPEKCRCEgttvdcsgqkltkipdhipqytaELRLNNNEFTVLEATG 535
Cdd:cd00116    138 -----ALEKLVLG-----RNRLEGASCEALAkaLRANRDLK-----------------------ELNLANNGIGDAGIRA 184

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  536 IFKKLP---QLRKINLSNNKITDIEEGTFEGAsgvneliltsnrlegvhysmLKGLGGLRTLMLRSNRISCVN-----NG 607
Cdd:cd00116    185 LAEGLKancNLEVLDLNNNGLTDEGASALAET--------------------LASLKSLEVLNLGDNNLTDAGaaalaSA 244

                          250
                   ....*....|....*....
gi 1207106434  608 SFTGLSSVRLLSLYDNLIT 626
Cdd:cd00116    245 LLSPNISLLTLSLSCNDIT 263
LRR_9 pfam14580
Leucine-rich repeat;
523-602 1.87e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.90  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  523 LNNNEFTVLEAtgiFKKLPQLRKINLSNNKITDIEEGTFEGASGVNELILTSNRL-EGVHYSMLKGLGGLRTLMLRSNRI 601
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLqELGDLDPLASLKKLTFLSLLRNPV 125


                   .
gi 1207106434  602 S 602
Cdd:pfam14580  126 T 126
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 290-440 1.99e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.47  E-value: 1.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  290 PETITEIRLEQNSI-----KIIpAGAFAPYKRLRRIDLSNNQIT-----ELAsDSFQGLRSLNSLVLYGNKITE-----L 354
Cdd:COG5238    207 NTTVTTLWLKRNPIgdegaEIL-AEALKGNKSLTTLDLSNNQIGdegviALA-EALKNNTTVETLYLSGNQIGAegaiaL 284

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  355 PKGLfDGLFSLQLLLLNANKINCLRVDSFQD-LQN---LNLLSLYDNKLQTI-AKGTFSSL---RAIQTLHLAQNPfMCD 426
Cdd:COG5238    285 AKAL-QGNTTLTSLDLSVNRIGDEGAIALAEgLQGnktLHTLNLAYNGIGAQgAIALAKALqenTTLHSLDLSDNQ-IGD 362

                          170
                   ....*....|....
gi 1207106434  427 CHLKWLADYLQDNP 440
Cdd:COG5238    363 EGAIALAKYLEGNT 376
LRRCT smart00082
Leucine rich repeat C-terminal domain;
202-237 2.96e-03

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 37.02  E-value: 2.96e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1207106434   202 NNLLCDCNVAWLSDWLRQRPRL--GLYTQCMAPPSLRG 237
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLqdPVDLRCASPSSLRG 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 955-987 4.52e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 4.52e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207106434  955 CISNPCQNGGTCHLKdgeENTHWCVCPEGFEGD 987
Cdd:pfam00008    1 CAPNPCSNGGTCVDT---PGGYTCICPEGYTGK 30
LRR smart00370
Leucine-rich repeats, outliers;
540-563 5.58e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 5.58e-03
                            10        20
                    ....*....|....*....|....
gi 1207106434   540 LPQLRKINLSNNKITDIEEGTFEG 563
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
540-563 5.58e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 5.58e-03
                            10        20
                    ....*....|....*....|....
gi 1207106434   540 LPQLRKINLSNNKITDIEEGTFEG 563
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 740-824 6.30e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 6.30e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207106434  740 TELYLD------GNEFTQVP---LELSNykHLTLIDLSNNQISTLSnhSFSNMSELLTLILSYNRLRCIP--AKAFDGLK 808
Cdd:cd21340     93 EELHIEnqrlppGEKLTFDPrslAALSN--SLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                           90
                   ....*....|....*.
gi 1207106434  809 SLRLLSLHGNDIAVIP 824
Cdd:cd21340    169 SLRELDLTGNPVCKKP 184
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 916-945 6.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.38e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1207106434  916 CLSNPCKNDGTCSNHPVDfYRCTCPYGFKG 945
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGG-YTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 996-1023 6.44e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 6.44e-03
                           10        20
                   ....*....|....*....|....*...
gi 1207106434  996 CEDNDCENNSTCVDGINNYTCLCSPEYT 1023
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYT 28
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 958-990 7.25e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 7.25e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1207106434  958 NPCQNGGTCHLKDGeenTHWCVCPEGFEGDECE 990
Cdd:cd00054      9 NPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 72-108 9.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 9.53e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1207106434   72 KNLRVLQLMENKISSIErgAFQDLQELERLRLNRNNL 108
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1050-1075 9.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.05  E-value: 9.84e-03
                           10        20
                   ....*....|....*....|....*.
gi 1207106434 1050 CQHDSKCILTAKGFMCECTPGYTGEH 1075
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGKR 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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