|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
886-1114 |
3.44e-60 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 205.29 E-value: 3.44e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 886 FRKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLATLkvpmtdkpnSTVNFR 965
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 966 KLLLNRCQKEFEKDKMdddafekKHREleaatassererlqeeleeaKDKARRRSIGNIKFIGELFKLRMLTEAIMHDCV 1045
Cdd:pfam02854 72 IHLLNRLQEEFEKRFE-------LEEN--------------------EQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195306 1046 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLHN 1114
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
887-1111 |
1.93e-50 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 177.55 E-value: 1.93e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 887 RKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLAtLKVPmtdkpnstvNFRK 966
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 967 LLLNRCQKEFEKDKMDDDAfekkhreleaatassererlqeeleeakdKARRRSIGNIKFIGELFKLRMLTEAIMHDCVV 1046
Cdd:smart00543 72 LLLERLQEEFEKGLESEEE-----------------------------SDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195306 1047 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1111
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1552-1687 |
2.45e-48 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 168.62 E-value: 2.45e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1552 LSPEELNKQLEKLLLEDMVGDEqIFDWVEANLDESEMSSAPFVRALMTAVCKAAVkTEGSSCKVDLSIIQTRLPVLHKYL 1631
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAI-EEKSLPEKEKALLEKYAPLLQKYL 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195306 1632 NSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPA 1687
Cdd:cd11559 79 DDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1354-1465 |
1.63e-33 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 125.47 E-value: 1.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1354 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1433
Cdd:pfam02847 2 KRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81
|
90 100 110
....*....|....*....|....*....|..
gi 1207195306 1434 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1465
Cdd:pfam02847 82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1354-1465 |
1.05e-31 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 120.43 E-value: 1.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1354 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1433
Cdd:smart00544 2 KKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWRL 81
|
90 100 110
....*....|....*....|....*....|..
gi 1207195306 1434 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1465
Cdd:smart00544 82 LEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1625-1709 |
1.34e-26 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 104.68 E-value: 1.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1625 PVLHKYLNSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPAEqqGKGVALKSVTAFFT 1704
Cdd:smart00515 1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78
|
....*
gi 1207195306 1705 WLREA 1709
Cdd:smart00515 79 WLQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1638-1714 |
1.02e-25 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 101.84 E-value: 1.02e-25
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195306 1638 QLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEvSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1714
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWW-EDVSSAEKGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
59-615 |
3.07e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 82.29 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 59 PPPLDERIFSTQPVSAVYSVQ---RPPGPPFTAHEINKGHPNLAATP--PG--HASSPGLSQVSVSTVSTahlygHPKGW 131
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRpapRPSEPAVTSRARRPDAPPQSARPraPVddRGDPRGPAPPSPLPPDT-----HAPDP 2626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 132 EPGGGSPYTTgQNAGTTPLVYSPPTQPMNAQPQSRpfAPGPRPTHHQG-GFRSIQFFQRTQMQTARPTIPSNTPPIRPTS 210
Cdd:PHA03247 2627 PPPSPSPAAN-EPDPHPPPTVPPPERPRDDPAPGR--VSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 211 QTPTAAvysPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQyvgPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYY 290
Cdd:PHA03247 2704 PPPTPE---PAPHALVSATPLPPGPAAARQASPALPAAPAPP---AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA 2777
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 291 PGQPVYTPSP--PIIVPTPQQPPPAKREKKTIRIRDPNQGgkdvtdEILSGVGLSRNPTPPVGRPSSTPTPPQQLNSQVA 368
Cdd:PHA03247 2778 GPPRRLTRPAvaSLSESRESLPSPWDPADPPAAVLAPAAA------LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 369 DHGHIMYNVDSS---PHLPAPFNLKADDKPKLEF----SLQRTASPGLRQPDTPLERRDPSSPVQ---TPSSPPHKPELP 438
Cdd:PHA03247 2852 LGGSVAPGGDVRrrpPSRSPAAKPAAPARPPVRRlarpAVSRSTESFALPPDQPERPPQPQAPPPpqpQPQPPPPPQPQP 2931
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 439 PSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLTQHekAVNGLTDVdA 518
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH--SLSRVSSW-A 3008
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 519 APLSEELETQPREASpLLPTSSVP-QSEPRPVTPVLEEESDPINMDS--PLPPVEDD--AGCPDNVSPSLSTSTTAAIST 593
Cdd:PHA03247 3009 SSLALHEETDPPPVS-LKQTLWPPdDTEDSDADSLFDSDSERSDLEAldPLPPEPHDpfAHEPDPATPEAGARESPSSQF 3087
|
570 580
....*....|....*....|..
gi 1207195306 594 TPPapppglshPSQVSAALDRR 615
Cdd:PHA03247 3088 GPP--------PLSANAALSRR 3101
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
188-606 |
1.73e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 59.78 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 188 QRTQMQTARPTIPSNTPPIRPTSQTPTAAvyspnqhimmtmAHMPFHSPQTAQYYIPqyrhsaPQYVGPPQQYPVQPTGP 267
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAASPPSPPPPGT------------TQAATAGPTPSAPSVP------PQGSPATSQPPNQTQST 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 268 STFYAAASPGEFPAPYAAGPPYYPGQPVYTPSPPIIVPtPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLsrnPT 347
Cdd:pfam03154 225 AAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVS-PQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPF---PL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 348 PPVGRPSSTPTPPQqlnSQVADHGHimynvdSSPHLPAPFNLKADDKPKLEFSLQRT--ASPGLRQPDT--------PLE 417
Cdd:pfam03154 301 TPQSSQSQVPPGPS---PAAPGQSQ------QRIHTPPSQSQLQSQQPPREQPLPPAplSMPHIKPPPTtpipqlpnPQS 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 418 RRDPS-----SPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSS 492
Cdd:pfam03154 372 HKHPPhlsgpSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 493 SPPPQSLSGSLTQHEKAVNGLTDVDAAplseelETQPREASPLLPTSSVPQSEPRPVTPVLeeesdPINMDSPLPPVEDD 572
Cdd:pfam03154 452 GLHQVPSQSPFPQHPFVPGGPPPITPP------SGPPTSTSSAMPGIQPPSSASVSSSGPV-----PAAVSCPLPPVQIK 520
|
410 420 430
....*....|....*....|....*....|....
gi 1207195306 573 AGCPDNvspslststtaaiSTTPPAPPPGLSHPS 606
Cdd:pfam03154 521 EEALDE-------------AEEPESPPPPPRSPS 541
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1666-1712 |
1.46e-06 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 50.67 E-value: 1.46e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1207195306 1666 LYDEDVISEDAFYKWevSKDPAEQQGKGVALKSVTAFFTWLREAEEE 1712
Cdd:cd11560 150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
|
|
| Amelogenin |
smart00818 |
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem ... |
176-316 |
5.51e-04 |
|
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem to regulate formation of crystallites during the secretory stage of tooth enamel development and are thought to play a major role in the structural organisation and mineralisation of developing enamel. The extracellular matrix of the developing enamel comprises two major classes of protein: the hydrophobic amelogenins and the acidic enamelins. Circular dichroism studies of porcine amelogenin have shown that the protein consists of 3 discrete folding units: the N-terminal region appears to contain beta-strand structures, while the C-terminal region displays characteristics of a random coil conformation. Subsequent studies on the bovine protein have indicated the amelogenin structure to contain a repetitive beta-turn segment and a "beta-spiral" between Gln112 and Leu138, which sequester a (Pro, Leu, Gln) rich region. The beta-spiral offers a probable site for interactions with Ca2+ ions. Muatations in the human amelogenin gene (AMGX) cause X-linked hypoplastic amelogenesis imperfecta, a disease characterised by defective enamel. A 9bp deletion in exon 2 of AMGX results in the loss of codons for Ile5, Leu6, Phe7 and Ala8, and replacement by a new threonine codon, disrupting the 16-residue (Met1-Ala16) amelogenin signal peptide.
Pssm-ID: 197891 [Multi-domain] Cd Length: 165 Bit Score: 42.47 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 176 HHQGGFRSIQF--FQRTQMQTARPTIPSNTPPIRPTSQTPTaavysPNQHIMMTMAHMPFHSPQTAQYYIPqyrhsaPQY 253
Cdd:smart00818 36 HHQIIPVSQQHppTHTLQPHHHIPVLPAQQPVVPQQPLMPV-----PGQHSMTPTQHHQPNLPQPAQQPFQ------PQP 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207195306 254 VGPPQ-QYPVQPTGPstfyaaASPGEFPAPYAAGPPYYPGQPVytpsPPIIVPTPQQPPPA----KRE 316
Cdd:smart00818 105 LQPPQpQQPMQPQPP------VHPIPPLPPQPPLPPMFPMQPL----PPLLPDLPLEAWPAtdktKRE 162
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
1077-1354 |
4.44e-03 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 41.96 E-value: 4.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1077 KPRMDQYFNQMEKIVKERKTSSRIrfmlqDVIDLrlhnWVsRRADQGPKTIEQIHKDAKLEEQEEQRKVHQQLLSKDNKR 1156
Cdd:PTZ00108 1101 KEKVEKLNAELEKKEKELEKLKNT-----TPKDM----WL-EDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLR 1170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1157 RPVVQREETWSTVPMTKNSRTIDPAKIPKFSKSAIDEKIQLGPRAQVNWMKGSSGGAGAKASESDASRPSaslNRYSPLQ 1236
Cdd:PTZ00108 1171 KPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSV---KRLKSKK 1247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1237 PSALQTSSLPSTSPDFDSRRVLGSRG--SSGRERNDKPLSAGPARTGPISLSSSNKETPEELVQ---EVSRRDSNASDTP 1311
Cdd:PTZ00108 1248 NNSSKSSEDNDEFSSDDLSKEGKPKNapKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrlEGSLAALKKKKKS 1327
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1207195306 1312 KLLVSTADKS--RLENSQPRESAVKLEALSGPSPDKPALSEEEME 1354
Cdd:PTZ00108 1328 EKKTARKKKSktRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372
|
|
| Not5 |
COG5665 |
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; |
288-657 |
6.94e-03 |
|
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
Pssm-ID: 444384 [Multi-domain] Cd Length: 874 Bit Score: 41.19 E-value: 6.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 288 PYYPGQPVYTPSP---PIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLSRnptppVGRPSSTPTPPqqln 364
Cdd:COG5665 177 IAVPSAPAAPPNAvdySVLVPIAAQDPAASVSTPQAFNASATSGRSQHIVQAAKRVGVEW-----WGDPSLLATPP---- 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 365 sqvadHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLR-----QPDTPLE--RRDPSSPVQTPSSPPHKPEL 437
Cdd:COG5665 248 -----ATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTSNTPTSTakaqpQPPTKKQpaKEPPSDTASGNPSAPSVLIN 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 438 PPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLTQHEKAVNGLTdvD 517
Cdd:COG5665 323 SDSPTSEDPATASVPTTEETTAFTTPSSVPSTPAEKDTPATDLATPVSPTPPETSVDKKVSPDSATSSTKSEKEGGT--A 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 518 AAPLSEelETQPREASPLLPTSSVPQSEPRPVTPVLEEESDPINMDSPLPPVEDDAGCPDNVSPSLsTSTTAAISTTPPA 597
Cdd:COG5665 401 SSPMPP--NIAIGAKDDVDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAGSDLEPENTT-LRDPAPNAIPPPE 477
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 598 PPPGLSHPSQVSAALDrrpSNGAEIKETGKENEALPDKRGEPFLQSRKSSNQATSSAPKT 657
Cdd:COG5665 478 DPSTIGRLSSGDKLAN---ETGPPVIRRDSTPSSTADQSIVGVLAFGLDQRTQAEISVEA 534
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
886-1114 |
3.44e-60 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 205.29 E-value: 3.44e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 886 FRKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLATLkvpmtdkpnSTVNFR 965
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNLR---------NPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 966 KLLLNRCQKEFEKDKMdddafekKHREleaatassererlqeeleeaKDKARRRSIGNIKFIGELFKLRMLTEAIMHDCV 1045
Cdd:pfam02854 72 IHLLNRLQEEFEKRFE-------LEEN--------------------EQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195306 1046 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERK---TSSRIRFMLQDVIDLRLHN 1114
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVLSKDdpkLSSRLRFMLQDLIELRKNK 203
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
887-1111 |
1.93e-50 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 177.55 E-value: 1.93e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 887 RKVRSILNKLTPQMFSQLMKQVTDLTIDTEERLKGVIDLVFEKAINEPSFSVAYGNMCSCLAtLKVPmtdkpnstvNFRK 966
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLN-AKNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 967 LLLNRCQKEFEKDKMDDDAfekkhreleaatassererlqeeleeakdKARRRSIGNIKFIGELFKLRMLTEAIMHDCVV 1046
Cdd:smart00543 72 LLLERLQEEFEKGLESEEE-----------------------------SDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195306 1047 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKT---SSRIRFMLQDVIDLR 1111
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELR 197
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1552-1687 |
2.45e-48 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 168.62 E-value: 2.45e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1552 LSPEELNKQLEKLLLEDMVGDEqIFDWVEANLDESEMSSAPFVRALMTAVCKAAVkTEGSSCKVDLSIIQTRLPVLHKYL 1631
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDE-LYKWIKENVSPELYASPGFVRALMTAVLKYAI-EEKSLPEKEKALLEKYAPLLQKYL 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195306 1632 NSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPA 1687
Cdd:cd11559 79 DDDEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1354-1465 |
1.63e-33 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 125.47 E-value: 1.63e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1354 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1433
Cdd:pfam02847 2 KRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWRV 81
|
90 100 110
....*....|....*....|....*....|..
gi 1207195306 1434 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1465
Cdd:pfam02847 82 LEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1354-1465 |
1.05e-31 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 120.43 E-value: 1.05e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1354 ERRSKSIIDEFLHINDYKEALQCVEELEQSAMLYVFVRVGVESTLERSQITRDHMGQLLFQLLQAGVLLKLQFFKGFSET 1433
Cdd:smart00544 2 KKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWRL 81
|
90 100 110
....*....|....*....|....*....|..
gi 1207195306 1434 LELADDMAIDIPHIWLYLAELVTPVLREGGIS 1465
Cdd:smart00544 82 LEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1625-1709 |
1.34e-26 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 104.68 E-value: 1.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1625 PVLHKYLNSDTERQLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEVSKDPAEqqGKGVALKSVTAFFT 1704
Cdd:smart00515 1 GPLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVT 78
|
....*
gi 1207195306 1705 WLREA 1709
Cdd:smart00515 79 WLQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1638-1714 |
1.02e-25 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 101.84 E-value: 1.02e-25
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195306 1638 QLQALYALQALIVKLDQPANLLRMFFDCLYDEDVISEDAFYKWEvSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1714
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWW-EDVSSAEKGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| W2 |
cd11473 |
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ... |
1555-1681 |
2.51e-21 |
|
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211395 Cd Length: 135 Bit Score: 91.38 E-value: 2.51e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1555 EELNKQLEKLLLEDMVGDEQIFDWVEANLDESEMSSAPFVRALMTAVCKAAVKTEGSS---CKVDLSIIQTRLPVLHKYL 1631
Cdd:cd11473 4 KKLRDSLLKELEEDKSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADSISltqKEQLVLVLKKYGPVLRELL 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1207195306 1632 NSDTERQLQALYALQAL--IVKLDQPANLLRMFFDCLYDEDVISEDAFYKWE 1681
Cdd:cd11473 84 KLIKKDQLYLLLKIEKLclQLKLSELISLLEKILDLLYDADVLSEEAILSWF 135
|
|
| W2_eIF2B_epsilon |
cd11558 |
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ... |
1595-1714 |
4.57e-16 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211396 Cd Length: 169 Bit Score: 77.68 E-value: 4.57e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1595 RALMTAVCKAAVKTEGSSCKVDLSIIQTRL----PVLHKYLNSDTErQLQALYALQALIVKLDQPANLLRMFFDCLYDED 1670
Cdd:cd11558 47 RAVVKALLELILEVSSTSTAELLEALKKLLskwgPLLENYVKSQDD-QVELLLALEEFCLESEEGGPLFAKLLHALYDLD 125
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1207195306 1671 VISEDAFYKWEVSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1714
Cdd:cd11558 126 ILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
59-615 |
3.07e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 82.29 E-value: 3.07e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 59 PPPLDERIFSTQPVSAVYSVQ---RPPGPPFTAHEINKGHPNLAATP--PG--HASSPGLSQVSVSTVSTahlygHPKGW 131
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRpapRPSEPAVTSRARRPDAPPQSARPraPVddRGDPRGPAPPSPLPPDT-----HAPDP 2626
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 132 EPGGGSPYTTgQNAGTTPLVYSPPTQPMNAQPQSRpfAPGPRPTHHQG-GFRSIQFFQRTQMQTARPTIPSNTPPIRPTS 210
Cdd:PHA03247 2627 PPPSPSPAAN-EPDPHPPPTVPPPERPRDDPAPGR--VSRPRRARRLGrAAQASSPPQRPRRRAARPTVGSLTSLADPPP 2703
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 211 QTPTAAvysPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQyvgPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYY 290
Cdd:PHA03247 2704 PPPTPE---PAPHALVSATPLPPGPAAARQASPALPAAPAPP---AVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA 2777
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 291 PGQPVYTPSP--PIIVPTPQQPPPAKREKKTIRIRDPNQGgkdvtdEILSGVGLSRNPTPPVGRPSSTPTPPQQLNSQVA 368
Cdd:PHA03247 2778 GPPRRLTRPAvaSLSESRESLPSPWDPADPPAAVLAPAAA------LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 369 DHGHIMYNVDSS---PHLPAPFNLKADDKPKLEF----SLQRTASPGLRQPDTPLERRDPSSPVQ---TPSSPPHKPELP 438
Cdd:PHA03247 2852 LGGSVAPGGDVRrrpPSRSPAAKPAAPARPPVRRlarpAVSRSTESFALPPDQPERPPQPQAPPPpqpQPQPPPPPQPQP 2931
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 439 PSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLTQHekAVNGLTDVdA 518
Cdd:PHA03247 2932 PPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH--SLSRVSSW-A 3008
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 519 APLSEELETQPREASpLLPTSSVP-QSEPRPVTPVLEEESDPINMDS--PLPPVEDD--AGCPDNVSPSLSTSTTAAIST 593
Cdd:PHA03247 3009 SSLALHEETDPPPVS-LKQTLWPPdDTEDSDADSLFDSDSERSDLEAldPLPPEPHDpfAHEPDPATPEAGARESPSSQF 3087
|
570 580
....*....|....*....|..
gi 1207195306 594 TPPapppglshPSQVSAALDRR 615
Cdd:PHA03247 3088 GPP--------PLSANAALSRR 3101
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
57-667 |
1.39e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 79.98 E-value: 1.39e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 57 RVPPPLDERIFSTQPVSAVYSVQRPPGPP---FTAHE-------INKGHPNLAATP----PGHASSPGLSQVSVSTVSTA 122
Cdd:PHA03247 2393 RSPPCLVLVDISMAPLFVLWEQPDPPGPPdvrFVGSEeieelpfVSPGGDVLAGLAadgdPFFARTILGAPFSLSLLLGE 2472
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 123 HLYGHPKGWEPG--------GGSPyttGQNAGTTPLVYSPPTqPMNAQPQSRPFAPGPRPTHHQ--GGFRSIQFFQRTQM 192
Cdd:PHA03247 2473 LFPGAPVYRRPAearfpfaaGAAP---DPGGGGPPDPDAPPA-PSRLAPAILPDEPVGEPVHPRmlTWIRGLEELASDDA 2548
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 193 QTARPTIPSNTPPIRPTSQTPTA-AVYSPNQHIMMTMAHMPFHSPQTAQYYIP-----QYRHSAPQYVGPPQQYPVQPTG 266
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVPPPrPAPRPSEPAVTSRARRPDAPPQSARPRAPvddrgDPRGPAPPSPLPPDTHAPDPPP 2628
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 267 PSTFYAAASPGEFPApyAAGPPyyPGQPVYTPSPPIIVPtpqqPPPAKREKKTIRIRDPNQGGKD--VTDEILSGVGLSR 344
Cdd:PHA03247 2629 PSPSPAANEPDPHPP--PTVPP--PERPRDDPAPGRVSR----PRRARRLGRAAQASSPPQRPRRraARPTVGSLTSLAD 2700
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 345 NPTPPvgrPSSTPTPPQQLNSQVADHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLrqPDTPLERRDPSSP 424
Cdd:PHA03247 2701 PPPPP---PTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT--TAGPPAPAPPAAP 2775
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 425 VQTPssPPHKPelPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLT 504
Cdd:PHA03247 2776 AAGP--PRRLT--RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 505 QHEKAVNGltdvdaAPLSEELETQPREASPLLPTSSVPQSEPRPVTPvLEEESDPINMDSPLPPVEDDAGCPdnvsPSLS 584
Cdd:PHA03247 2852 LGGSVAPG------GDVRRRPPSRSPAAKPAAPARPPVRRLARPAVS-RSTESFALPPDQPERPPQPQAPPP----PQPQ 2920
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 585 TSTTAAISTTPPAPPPGLShPSQVSAALDRRPSNGAEIKETGKENEALPDKRgEPFLQSRKSSNQATSSAPKTWKKPKED 664
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRP-QPPLAPTTDPAGAGEPSGAVPQPWLGALVPGR-VAVPRFRVPQPAPSREAPASSTPPLTG 2998
|
...
gi 1207195306 665 MPV 667
Cdd:PHA03247 2999 HSL 3001
|
|
| W2_eIF5 |
cd11561 |
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ... |
1573-1714 |
6.00e-11 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211399 Cd Length: 157 Bit Score: 62.63 E-value: 6.00e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1573 EQIFDWVEANLDESEMS-------SAPFVRALMTAVCKAAVKTEGSSCKVDLsiIQTRLPVLHKYLNSDtERQLQALYAL 1645
Cdd:cd11561 9 DELGEFLKKNKDESGLSelkeilkEAERLDVVKDKAVLVLAEVLFDENIVKE--IKKRKALLLKLVTDE-KAQKALLGGI 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195306 1646 QALIVK-----LDQPANLLRmffdCLYDEDVISEDAFYKW--EVSKDPAEQQGKGVALKSVTAFFTWLREAEEESE 1714
Cdd:cd11561 86 ERFCGKhspelLKKVPLILK----ALYDNDILEEEVILKWyeKVSKKYVSKEKSKKVRKAAEPFVEWLEEAEEEEE 157
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
52-459 |
1.35e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.42 E-value: 1.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 52 PSRYPRV--PPPLDERIFSTQPVSAVYSVQRPPGPPFT----AHEINKGHPNLAATPPGHASSPGLSQVSVsTVSTAHLY 125
Cdd:PHA03247 2670 LGRAAQAssPPQRPRRRAARPTVGSLTSLADPPPPPPTpepaPHALVSATPLPPGPAAARQASPALPAAPA-PPAVPAGP 2748
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 126 GHPKGWEPGGGSPYTTGQNAGTTPLVYSPPTQPMNAQP------QSRPFAPGPR-PTHHQGGFRSIQFFQRTQMQ----- 193
Cdd:PHA03247 2749 ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPavaslsESRESLPSPWdPADPPAAVLAPAAALPPAASpagpl 2828
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 194 ----TARPTIPSNTPPIRPTSQTPTAAVySPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPst 269
Cdd:PHA03247 2829 ppptSAQPTAPPPPPGPPPPSLPLGGSV-APGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP-- 2905
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 270 fyaAASPGEFPAPYAAGPPYYPGQPVYTPSPPiivPTPQQPPPAKREKKTIRIRDPNQGgkdVTDEILSGVGLSRNPTPP 349
Cdd:PHA03247 2906 ---ERPPQPQAPPPPQPQPQPPPPPQPQPPPP---PPPRPQPPLAPTTDPAGAGEPSGA---VPQPWLGALVPGRVAVPR 2976
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 350 VGRPSSTPTPPQQLNSQVADHGHIMYNVDSSPHLPApFNLKADDKPkleFSLQRTASPglrqPDTpLERRDPSSPVQTPS 429
Cdd:PHA03247 2977 FRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLA-LHEETDPPP---VSLKQTLWP----PDD-TEDSDADSLFDSDS 3047
|
410 420 430
....*....|....*....|....*....|
gi 1207195306 430 SPPHKPELPPSDSETASSVATAPTPSIPAS 459
Cdd:PHA03247 3048 ERSDLEALDPLPPEPHDPFAHEPDPATPEA 3077
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
32-322 |
5.55e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.49 E-value: 5.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 32 RTTLTTVPLQSVAQQVFLNFPSR--YPRVPPPlderifSTQPVSAVySVQRPPGPPFTAHEINKGHPNL-AATPPGHASS 108
Cdd:PHA03247 2713 HALVSATPLPPGPAAARQASPALpaAPAPPAV------PAGPATPG-GPARPARPPTTAGPPAPAPPAApAAGPPRRLTR 2785
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 109 PGLSQVSVSTVSTahlyghPKGWEPGGG----SPYTTGQNAGTTPLVYSPPtqPMNAQPQSRPFAPGPRPTHH--QGGFR 182
Cdd:PHA03247 2786 PAVASLSESRESL------PSPWDPADPpaavLAPAAALPPAASPAGPLPP--PTSAQPTAPPPPPGPPPPSLplGGSVA 2857
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 183 SIQFFQR---TQMQTARPTIPSNtPPIRPTSQTPTAAvySPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQQ 259
Cdd:PHA03247 2858 PGGDVRRrppSRSPAAKPAAPAR-PPVRRLARPAVSR--STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPP 2934
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 260 YPVQPTGP-----STFYAAASPGEFPAPY--AAGPPYYPGQPVYTPSPPIIVPTPQQPPPAKREKKTIRI 322
Cdd:PHA03247 2935 PPPRPQPPlapttDPAGAGEPSGAVPQPWlgALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRV 3004
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
188-606 |
1.73e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 59.78 E-value: 1.73e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 188 QRTQMQTARPTIPSNTPPIRPTSQTPTAAvyspnqhimmtmAHMPFHSPQTAQYYIPqyrhsaPQYVGPPQQYPVQPTGP 267
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAASPPSPPPPGT------------TQAATAGPTPSAPSVP------PQGSPATSQPPNQTQST 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 268 STFYAAASPGEFPAPYAAGPPYYPGQPVYTPSPPIIVPtPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLsrnPT 347
Cdd:pfam03154 225 AAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVS-PQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQPF---PL 300
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 348 PPVGRPSSTPTPPQqlnSQVADHGHimynvdSSPHLPAPFNLKADDKPKLEFSLQRT--ASPGLRQPDT--------PLE 417
Cdd:pfam03154 301 TPQSSQSQVPPGPS---PAAPGQSQ------QRIHTPPSQSQLQSQQPPREQPLPPAplSMPHIKPPPTtpipqlpnPQS 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 418 RRDPS-----SPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSS 492
Cdd:pfam03154 372 HKHPPhlsgpSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 493 SPPPQSLSGSLTQHEKAVNGLTDVDAAplseelETQPREASPLLPTSSVPQSEPRPVTPVLeeesdPINMDSPLPPVEDD 572
Cdd:pfam03154 452 GLHQVPSQSPFPQHPFVPGGPPPITPP------SGPPTSTSSAMPGIQPPSSASVSSSGPV-----PAAVSCPLPPVQIK 520
|
410 420 430
....*....|....*....|....*....|....
gi 1207195306 573 AGCPDNvspslststtaaiSTTPPAPPPGLSHPS 606
Cdd:pfam03154 521 EEALDE-------------AEEPESPPPPPRSPS 541
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
154-313 |
9.72e-07 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 53.68 E-value: 9.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 154 PPTQPMNAQPQSRpfAPGPRP----THHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMA 229
Cdd:PRK14086 99 PPHARRTSEPELP--RPGRRPyegyGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPP 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 230 HMPFHSPqtAQYYIPQYRHSAPQYVGPPQQYPVQPTGPSTFYAAASPGE------FPAPYAA-------GPPYYPGQPVY 296
Cdd:PRK14086 177 RAPYASP--ASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRdrtdrpEPPPGAGhvhrggpGPPERDDAPVV 254
|
170
....*....|....*..
gi 1207195306 297 TPSPPIIVPTPQQPPPA 313
Cdd:PRK14086 255 PIRPSAPGPLAAQPAPA 271
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
53-478 |
1.36e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 53.62 E-value: 1.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 53 SRYPRVPPPLDERIFSTQPVSAVYSVQRPPGppftaheINKGHPNLAATPPGhasSPGLSQVSVSTVSTAHLYGHPKGWE 132
Cdd:pfam03154 143 STSPSIPSPQDNESDSDSSAQQQILQTQPPV-------LQAQSGAASPPSPP---PPGTTQAATAGPTPSAPSVPPQGSP 212
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 133 PGGGSPYTTGQNAGTTPLVYS-------------PPTQPMN--AQPQSRPFAPGPRPTHHQggfrsiqffQRTQMQTARP 197
Cdd:pfam03154 213 ATSQPPNQTQSTAAPHTLIQQtptlhpqrlpsphPPLQPMTqpPPPSQVSPQPLPQPSLHG---------QMPPMPHSLQ 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 198 TIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQyvgPPQQYPVqPTGPSTFYAAASPG 277
Cdd:pfam03154 284 TGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ---PPREQPL-PPAPLSMPHIKPPP 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 278 EFPAPYAAGPPYYPGQPVYTPSPPIIVPTPQQPPPAKREKKTIRIRDPNqggkdvtdeilsgvglSRNPTPPVGRPSSTP 357
Cdd:pfam03154 360 TTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPP----------------SAHPPPLQLMPQSQQ 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 358 TPPQQLNSQVADHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDTPLERRDPSSP-VQTPSSpphkpe 436
Cdd:pfam03154 424 LPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPgIQPPSS------ 497
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 1207195306 437 LPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKA 478
Cdd:pfam03154 498 ASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRS 539
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1666-1712 |
1.46e-06 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 50.67 E-value: 1.46e-06
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 1207195306 1666 LYDEDVISEDAFYKWevSKDPAEQQGKGVALKSVTAFFTWLREAEEE 1712
Cdd:cd11560 150 LYKADVLSEDAILKW--YKKGHSPKGKQVFLKQMEPFVEWLQEAEEE 194
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
266-668 |
2.31e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 52.87 E-value: 2.31e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 266 GPSTFYAAASPGEFPAPyAAGPPYYPGQPvyTPSPPIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDeilsgvglSRN 345
Cdd:PHA03307 44 VSDSAELAAVTVVAGAA-ACDRFEPPTGP--PPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPP--------GPS 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 346 PTPPVGRPSSTPTPPqqlnsqvADHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDTPLERrdPSSPV 425
Cdd:PHA03307 113 SPDPPPPTPPPASPP-------PSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSS--PEETA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 426 QTPSSPPhkPELPPSDSETASSvATAPTPSIPASTEESADAPSPL--------AEPSLTKAITPEPESSEPEKSSSPPPQ 497
Cdd:PHA03307 184 RAPSSPP--AEPPPSTPPAAAS-PRPPRRSSPISASASSPAPAPGrsaaddagASSSDSSSSESSGCGWGPENECPLPRP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 498 SLSGSLTQHEKAVNG-LTDVDAAPLSEELETQPREASPLLPTSSVPQSEPRPVTPVLEEESDPINMDSPLPPVEDDAGCP 576
Cdd:PHA03307 261 APITLPTRIWEASGWnGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAA 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 577 DNVSPSLSTSTTAAISTTPPAPPPGLSHPSQVSAALDRRPSNG-AEIKETGKENEALPDKRGEPFLQ----SRKSSNQAT 651
Cdd:PHA03307 341 VSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGrPTRRRARAAVAGRARRRDATGRFpagrPRPSPLDAG 420
|
410
....*....|....*..
gi 1207195306 652 SSAPKTWKKPKEDMPVG 668
Cdd:PHA03307 421 AASGAFYARYPLLTPSG 437
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
79-469 |
8.04e-06 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 50.94 E-value: 8.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 79 QRPPGPP-FTAHEINKGHPNLAATPPGHASSPglsqVSVSTvSTAHLYGHPKGWEPGGGSPYTTGQNAGTTPLVYSPPTQ 157
Cdd:PHA03307 22 PRPPATPgDAADDLLSGSQGQLVSDSAELAAV----TVVAG-AAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLA 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 158 PMNAQPQSRPFAPGPRPThhqggfrsiqffqRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQ 237
Cdd:PHA03307 97 PASPAREGSPTPPGPSSP-------------DPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 238 TAQyyipqyrhsapqyVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYYPGQPVytPSPPIIVPTPQQPPPAKREK 317
Cdd:PHA03307 164 SDA-------------ASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPR--RSSPISASASSPAPAPGRSA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 318 KTIRIRDPNQGGKDVTDEILSGvGLSRNPTPPVGrPSSTPTPPQQlnsqvadhgHIMYNVDSSPHLPAPfnlkaddkpkl 397
Cdd:PHA03307 229 ADDAGASSSDSSSSESSGCGWG-PENECPLPRPA-PITLPTRIWE---------ASGWNGPSSRPGPAS----------- 286
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207195306 398 efslqrtASPGLRQPDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSP 469
Cdd:PHA03307 287 -------SSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSP 351
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
68-453 |
2.18e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 49.68 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 68 STQPVSAVYSVQRPPGPPFTAHEINKGHPNLAATPPGHASSPGLsqvsvstvsTAHLYGHPKGWEPGGGSPYTTGQNAGT 147
Cdd:PHA03378 555 STEPVHDQLLPAPGLGPLQIQPLTSPTTSQLASSAPSYAQTPWP---------VPHPSQTPEPPTTQSHIPETSAPRQWP 625
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 148 TPLvYSPPTQPMNAQPQsrPFAPGPRPTHHQGGFRSIQFFQRTQMQTarPTIPSNTPPIRPTSQTPTAAvySPnqhimmT 227
Cdd:PHA03378 626 MPL-RPIPMRPLRMQPI--TFNVLVFPTPHQPPQVEITPYKPTWTQI--GHIPYQPSPTGANTMLPIQW--AP------G 692
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 228 MAHMPFHSPQtaqyyipqyRHSAPQYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYYPGQPVYTPSPPIIVPTP 307
Cdd:PHA03378 693 TMQPPPRAPT---------PMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGR 763
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 308 QQPPPAKREKKTirIRDPNQGGKDVTDEILSGvglsrnPTP---PVGRPSSTPTPPQQLNSQVADHGHIMYNVDSSPHLP 384
Cdd:PHA03378 764 ARPPAAAPGAPT--PQPPPQAPPAPQQRPRGA------PTPqppPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKR 835
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207195306 385 APFNLKADDKPKLEFSLQRTASPGLRQPDTPLERRDPSSPVQTPSSPPHKpeLPPSDSETASSVATAPT 453
Cdd:PHA03378 836 GRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQ--LGSVRAAAASTVTQAPT 902
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
25-264 |
2.42e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 49.26 E-value: 2.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 25 QLSASQLRTTLTtVPLQSVAQQVFLNFPSRYPRVPPPLDERIFSTQPVSAVYSVQRPPGPpftaheINKGHPNLA----- 99
Cdd:pfam09770 94 AIEEEQVRFNRQ-QPAARAAQSSAQPPASSLPQYQYASQQSQQPSKPVRTGYEKYKEPEP------IPDLQVDASlwgva 166
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 100 ---ATPPGHASSPGLSQVSVSTVS---------TAHLYGHPKGWEPGGGSPYTTGQNAGTTPLVYSPPTQPMNAQPQSRP 167
Cdd:pfam09770 167 pkkAAAPAPAPQPAAQPASLPAPSrkmmsleevEAAMRAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQP 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 168 FAPGPRPTHHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHI------MMTMAHMPFHSPQTAQY 241
Cdd:pfam09770 247 QQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILqnpnrlSAARVGYPQNPQPGVQP 326
|
250 260
....*....|....*....|...
gi 1207195306 242 YIPQYRHSAPQYVGPPQQYPVQP 264
Cdd:pfam09770 327 APAHQAHRQQGSFGRQAPIITHP 349
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
149-311 |
3.27e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 48.93 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 149 PLVYSPPTQPMNA-QPQSRPFAPGPRPTHHQGGFRSiqffqrtQMQTARPTIPSNTPPIRPTSQTPTAAVYSPNQHIMMT 227
Cdd:PRK10263 347 ASVDVPPAQPTVAwQPVPGPQTGEPVIAPAPEGYPQ-------QSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQP 419
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 228 MAHMPFHSPQTAQYYIPQYRHSAP--QYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYYPGQPVYTPSPPIIVP 305
Cdd:PRK10263 420 YYAPAPEQPAQQPYYAPAPEQPVAgnAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEET 499
|
....*.
gi 1207195306 306 TPQQPP 311
Cdd:PRK10263 500 KPARPP 505
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
265-480 |
3.61e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 48.72 E-value: 3.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 265 TGPSTfyAAASPGEFPAPYAAGPPYYPGQPVYTPSPPIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLSR 344
Cdd:PRK12323 372 AGPAT--AAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 345 NPTPPVGRPSSTPTPPQQLNSQVADHGHIMYNVDSSPHLPAPfnlKADDKPKLEFSLQRTASPGLRQPDTPLERRDPSSP 424
Cdd:PRK12323 450 PAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP---ADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESI 526
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1207195306 425 VQTPSSPPHKPELPPSDSETASSVATAPTPSIPAsteeSADAPSPLAEPSLTKAIT 480
Cdd:PRK12323 527 PDPATADPDDAFETLAPAPAAAPAPRAAAATEPV----VAPRPPRASASGLPDMFD 578
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
291-552 |
5.97e-05 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 47.61 E-value: 5.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 291 PGQPVYT--PSPPIIVPTPQQPPPAKREKktirirDPNQGgKDVTDEILSGVGLSRNPTPPVGrPSSTPTPPQQLNSQVA 368
Cdd:PLN03209 330 PKESDAAdgPKPVPTKPVTPEAPSPPIEE------EPPQP-KAVVPRPLSPYTAYEDLKPPTS-PIPTPPSSSPASSKSV 401
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 369 DHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDtplerrdpsspVQTPSSPPHKPELPPSDSETASSV 448
Cdd:PLN03209 402 DAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYED-----------LKPPTSPSPTAPTGVSPSVSSTSS 470
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 449 ATA-PTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLTQHEKAVNGLTDVDAAPLSEELET 527
Cdd:PLN03209 471 VPAvPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVKVGNSAPPTALADEQHHAQP 550
|
250 260
....*....|....*....|....*.
gi 1207195306 528 QPREASPLLPTSSV-PQSEPRPVTPV 552
Cdd:PLN03209 551 KPRPLSPYTMYEDLkPPTSPTPSPVL 576
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
101-610 |
1.42e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 47.00 E-value: 1.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 101 TPPGHASSPGLSQVSVStvstahlyghpkgWEPGGGsPYTTGQNAGTTPLVYSPptQPMNAQPQSRPFAPGPRPTHHQGG 180
Cdd:PRK10263 343 TPPVASVDVPPAQPTVA-------------WQPVPG-PQTGEPVIAPAPEGYPQ--QSQYAQPAVQYNEPLQQPVQPQQP 406
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 181 FRSIQFFQRTQMQ--TARPTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQTA--QYYIPQYRHSAPQYVGP 256
Cdd:PRK10263 407 YYAPAAEQPAQQPyyAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTyqQPAAQEPLYQQPQPVEQ 486
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 257 P---QQYPV----QPTGPSTFY--------------AAASPGEFPAPYAAGPPYYPGQPVYTP-SPPIIVPTPQQPPPAk 314
Cdd:PRK10263 487 QpvvEPEPVveetKPARPPLYYfeeveekrarereqLAAWYQPIPEPVKEPEPIKSSLKAPSVaAVPPVEAAAAVSPLA- 565
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 315 rekktirirdpnQGGKDVTdeilSGVGLSRNPTPPVGRPSSTPTPPQQLNSQVAdhghimynvdssPHLPAPFNLKADDK 394
Cdd:PRK10263 566 ------------SGVKKAT----LATGAAATVAAPVFSLANSGGPRPQVKEGIG------------PQLPRPKRIRVPTR 617
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 395 PKL-----EFSLQRTASPGLRQPDtpleRRDPSSPVQTPSSPP---HKPELPPSDSETASS-VATAPTPSIPASTEESAD 465
Cdd:PRK10263 618 RELasygiKLPSQRAAEEKAREAQ----RNQYDSGDQYNDDEIdamQQDELARQFAQTQQQrYGEQYQHDVPVNAEDADA 693
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 466 ApsplAEPSLTKAITPEPESSEPEKSSSPPPQSLsgsltqhekavngLTDVDAAPLSEELETQPREasPLLPTSSVPQSE 545
Cdd:PRK10263 694 A----AEAELARQFAQTQQQRYSGEQPAGANPFS-------------LDDFEFSPMKALLDDGPHE--PLFTPIVEPVQQ 754
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195306 546 PRPVTPVLEEESDPinmDSPLPPVEDDAGCPDNVSPSlstsTTAAISTTPPAPPPGLSHPSQVSA 610
Cdd:PRK10263 755 PQQPVAPQQQYQQP---QQPVAPQPQYQQPQQPVAPQ----PQYQQPQQPVAPQPQYQQPQQPVA 812
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
210-474 |
1.63e-04 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 46.45 E-value: 1.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 210 SQTPTAAVYSPnqhimmTMAHMPFHSPQTAQYyIPQYRH-----SAPQYVGPPQQYP--VQPTGPSTFYAAASPGEFPAP 282
Cdd:pfam05109 422 SKAPESTTTSP------TLNTTGFAAPNTTTG-LPSSTHvptnlTAPASTGPTVSTAdvTSPTPAGTTSGASPVTPSPSP 494
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 283 YAAGPP------YYPGQPVYTPSPPIIVPTPQQPPPakrekkTIRIRDPNQGGKDVTDEILSGVGLSRNPTPPVGRPS-- 354
Cdd:pfam05109 495 RDNGTEskapdmTSPTSAVTTPTPNATSPTPAVTTP------TPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTpn 568
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 355 ---------------STPTPPQ------QLNSQVADHGHIMYNVDSSPHLPAPFN--LKADDKPKLEFSLQRTASPGLRq 411
Cdd:pfam05109 569 atiptlgktsptsavTTPTPNAtsptvgETSPQANTTNHTLGGTSSTPVVTSPPKnaTSAVTTGQHNITSSSTSSMSLR- 647
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207195306 412 PDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPS 474
Cdd:pfam05109 648 PSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQAS 710
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
211-320 |
3.91e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.46 E-value: 3.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 211 QTPTAAVYSPNQhimmtmahMPFHSPQTAQYYIPQYRHSApQYVGPPQQY--PVQPTGPSTFYAAASPGEFPAPYAAGP- 287
Cdd:PRK10263 738 DGPHEPLFTPIV--------EPVQQPQQPVAPQQQYQQPQ-QPVAPQPQYqqPQQPVAPQPQYQQPQQPVAPQPQYQQPq 808
|
90 100 110
....*....|....*....|....*....|....*...
gi 1207195306 288 -PYYPgQPVYTPSPPIIVPTPQ----QPPPAKREKKTI 320
Cdd:PRK10263 809 qPVAP-QPQYQQPQQPVAPQPQyqqpQQPVAPQPQDTL 845
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
133-331 |
4.82e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.98 E-value: 4.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 133 PGGGSPYTTGQNAGTTPLVYSPPTQPMNAQPQSRPFAPGPRPTHHQGGFRSIQFFQRTQMQTARPTIPSNTPPIRPTSQT 212
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 213 PTAAVYSPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQQYPVQPTGPSTFYAAAS---------PGEFPAPY 283
Cdd:PRK07764 670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSpaaddpvplPPEPDDPP 749
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1207195306 284 AAGPPYYPGQPVYTPSPPiiVPTPQQPPPAKREKKTIRIRDPNQGGKD 331
Cdd:PRK07764 750 DPAGAPAQPPPPPAPAPA--AAPAAAPPPSPPSEEEEMAEDDAPSMDD 795
|
|
| PRK10905 |
PRK10905 |
cell division protein DamX; Validated |
404-478 |
4.99e-04 |
|
cell division protein DamX; Validated
Pssm-ID: 236792 [Multi-domain] Cd Length: 328 Bit Score: 44.16 E-value: 4.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 404 TASPGLRQPDTPLERR----DPSSPVQTPSSPPHKPELPPSDSETASSVATAPTP---SIPASTEESADAPSPLAEPSLT 476
Cdd:PRK10905 144 KTQTAERPATTRPARKqaviEPKKPQATAKTEPKPVAQTPKRTEPAAPVASTKAPaatSTPAPKETATTAPVQTASPAQT 223
|
..
gi 1207195306 477 KA 478
Cdd:PRK10905 224 TA 225
|
|
| Amelogenin |
smart00818 |
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem ... |
176-316 |
5.51e-04 |
|
Amelogenins, cell adhesion proteins, play a role in the biomineralisation of teeth; They seem to regulate formation of crystallites during the secretory stage of tooth enamel development and are thought to play a major role in the structural organisation and mineralisation of developing enamel. The extracellular matrix of the developing enamel comprises two major classes of protein: the hydrophobic amelogenins and the acidic enamelins. Circular dichroism studies of porcine amelogenin have shown that the protein consists of 3 discrete folding units: the N-terminal region appears to contain beta-strand structures, while the C-terminal region displays characteristics of a random coil conformation. Subsequent studies on the bovine protein have indicated the amelogenin structure to contain a repetitive beta-turn segment and a "beta-spiral" between Gln112 and Leu138, which sequester a (Pro, Leu, Gln) rich region. The beta-spiral offers a probable site for interactions with Ca2+ ions. Muatations in the human amelogenin gene (AMGX) cause X-linked hypoplastic amelogenesis imperfecta, a disease characterised by defective enamel. A 9bp deletion in exon 2 of AMGX results in the loss of codons for Ile5, Leu6, Phe7 and Ala8, and replacement by a new threonine codon, disrupting the 16-residue (Met1-Ala16) amelogenin signal peptide.
Pssm-ID: 197891 [Multi-domain] Cd Length: 165 Bit Score: 42.47 E-value: 5.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 176 HHQGGFRSIQF--FQRTQMQTARPTIPSNTPPIRPTSQTPTaavysPNQHIMMTMAHMPFHSPQTAQYYIPqyrhsaPQY 253
Cdd:smart00818 36 HHQIIPVSQQHppTHTLQPHHHIPVLPAQQPVVPQQPLMPV-----PGQHSMTPTQHHQPNLPQPAQQPFQ------PQP 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207195306 254 VGPPQ-QYPVQPTGPstfyaaASPGEFPAPYAAGPPYYPGQPVytpsPPIIVPTPQQPPPA----KRE 316
Cdd:smart00818 105 LQPPQpQQPMQPQPP------VHPIPPLPPQPPLPPMFPMQPL----PPLLPDLPLEAWPAtdktKRE 162
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
412-577 |
1.25e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.71 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 412 PDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPA----------------STEESADAPSPLAEPSL 475
Cdd:PRK12323 383 AQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPApealaaarqasargpgGAPAPAPAPAAAPAAAA 462
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 476 TKAITPEPESSEPEKSSSPPPQSLSGSLTQHEK-----------AVNGLTDVDAAPLSEELETQPREASPLLPTSSVPQS 544
Cdd:PRK12323 463 RPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDpppweelppefASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLA 542
|
170 180 190
....*....|....*....|....*....|...
gi 1207195306 545 EPRPVTPVLEEESDPINMDSPLPPVEDDAGCPD 577
Cdd:PRK12323 543 PAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
295-479 |
2.09e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 42.16 E-value: 2.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 295 VYTPSPPIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLSRNPTppvGRPSSTPTPPQQLNSQVADhghim 374
Cdd:PHA02682 25 LFTKCPQATIPAPAAPCPPDADVDPLDKYSVKEAGRYYQSRLKANSACMQRPS---GQSPLAPSPACAAPAPACP----- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 375 ynvDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLRQPDTPleRRDPSSPVQTPSSPPHKPELPPSDSETASSV---ATA 451
Cdd:PHA02682 97 ---ACAPAAPAPAVTCPAPAPACPPATAPTCPPPAVCPAPA--RPAPACPPSTRQCPPAPPLPTPKPAPAAKPIflhNQL 171
|
170 180 190
....*....|....*....|....*....|.
gi 1207195306 452 PTPSIPAS---TEESADAPSPLAEPSLTKAI 479
Cdd:PHA02682 172 PPPDYPAAscpTIETAPAASPVLEPRIPDKI 202
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
250-473 |
2.33e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 2.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 250 APQYVGPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYYPGQPVyTPSPPIIVPTPQQPPPAkrekktirirdPNQGG 329
Cdd:PRK07764 589 GPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAA-APAEASAAPAPGVAAPE-----------HHPKH 656
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 330 KDVTDEILSGVGLSRNPTPPVGrpsSTPTPPQQLNSQVADHGhimynvdSSPHLPAPfnlKADDKPKLEFSLQRTASPgl 409
Cdd:PRK07764 657 VAVPDASDGGDGWPAKAGGAAP---AAPPPAPAPAAPAAPAG-------AAPAQPAP---APAATPPAGQADDPAAQP-- 721
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207195306 410 RQPDTPLERRDPSSPVQTPssPPHKPELPPSDSETASSvATAPTPSIPASTEESADAPSPLAEP 473
Cdd:PRK07764 722 PQAAQGASAPSPAADDPVP--LPPEPDDPPDPAGAPAQ-PPPPPAPAPAAAPAAAPPPSPPSEE 782
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
197-300 |
2.90e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 2.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 197 PTIPSNTPPIRPTSQTPTAAVYSPNQHIMMTMAHMPFHSPQTAQYYIPQYRHSAPQYVGPPQ---QYPVQPTGPSTFYAA 273
Cdd:PRK10263 740 PHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQpqyQQPQQPVAPQPQYQQ 819
|
90 100
....*....|....*....|....*..
gi 1207195306 274 ASpgefpAPYAAGPPYYPGQPVYTPSP 300
Cdd:PRK10263 820 PQ-----QPVAPQPQYQQPQQPVAPQP 841
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
255-473 |
4.27e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.23 E-value: 4.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 255 GPPQQYPVQPTGPSTFYAAASPGEFPAPYAAGPPYYPGQPVYTP----SPPIIVPTPQQPPPAKREKktirirDPNQGGK 330
Cdd:PHA03247 257 PPPVVGEGADRAPETARGATGPPPPPEAAAPNGAAAPPDGVWGAalagAPLALPAPPDPPPPAPAGD------AEEEDDE 330
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 331 DVTDEILSGVGLSRN--PTPPVGRPSSTPTPPQQLNsqvadhghimynvdssphlpapfNLKADDKPKLEFSLQRTASPG 408
Cdd:PHA03247 331 DGAMEVVSPLPRPRQhyPLGFPKRRRPTWTPPSSLE-----------------------DLSAGRHHPKRASLPTRKRRS 387
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195306 409 LRQPDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEP 473
Cdd:PHA03247 388 ARHAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPER 452
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
1077-1354 |
4.44e-03 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 41.96 E-value: 4.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1077 KPRMDQYFNQMEKIVKERKTSSRIrfmlqDVIDLrlhnWVsRRADQGPKTIEQIHKDAKLEEQEEQRKVHQQLLSKDNKR 1156
Cdd:PTZ00108 1101 KEKVEKLNAELEKKEKELEKLKNT-----TPKDM----WL-EDLDKFEEALEEQEEVEEKEIAKEQRLKSKTKGKASKLR 1170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1157 RPVVQREETWSTVPMTKNSRTIDPAKIPKFSKSAIDEKIQLGPRAQVNWMKGSSGGAGAKASESDASRPSaslNRYSPLQ 1236
Cdd:PTZ00108 1171 KPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKSSV---KRLKSKK 1247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 1237 PSALQTSSLPSTSPDFDSRRVLGSRG--SSGRERNDKPLSAGPARTGPISLSSSNKETPEELVQ---EVSRRDSNASDTP 1311
Cdd:PTZ00108 1248 NNSSKSSEDNDEFSSDDLSKEGKPKNapKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKVKkrlEGSLAALKKKKKS 1327
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1207195306 1312 KLLVSTADKS--RLENSQPRESAVKLEALSGPSPDKPALSEEEME 1354
Cdd:PTZ00108 1328 EKKTARKKKSktRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSE 1372
|
|
| Not5 |
COG5665 |
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]; |
288-657 |
6.94e-03 |
|
CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription];
Pssm-ID: 444384 [Multi-domain] Cd Length: 874 Bit Score: 41.19 E-value: 6.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 288 PYYPGQPVYTPSP---PIIVPTPQQPPPAKREKKTIRIRDPNQGGKDVTDEILSGVGLSRnptppVGRPSSTPTPPqqln 364
Cdd:COG5665 177 IAVPSAPAAPPNAvdySVLVPIAAQDPAASVSTPQAFNASATSGRSQHIVQAAKRVGVEW-----WGDPSLLATPP---- 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 365 sqvadHGHIMYNVDSSPHLPAPFNLKADDKPKLEFSLQRTASPGLR-----QPDTPLE--RRDPSSPVQTPSSPPHKPEL 437
Cdd:COG5665 248 -----ATPATEEKSSQQPKSQPTSPSGGTTPPSTNQLTTSNTPTSTakaqpQPPTKKQpaKEPPSDTASGNPSAPSVLIN 322
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 438 PPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLTKAITPEPESSEPEKSSSPPPQSLSGSLTQHEKAVNGLTdvD 517
Cdd:COG5665 323 SDSPTSEDPATASVPTTEETTAFTTPSSVPSTPAEKDTPATDLATPVSPTPPETSVDKKVSPDSATSSTKSEKEGGT--A 400
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 518 AAPLSEelETQPREASPLLPTSSVPQSEPRPVTPVLEEESDPINMDSPLPPVEDDAGCPDNVSPSLsTSTTAAISTTPPA 597
Cdd:COG5665 401 SSPMPP--NIAIGAKDDVDATDPSQEAKEYTKNAPMTPEADSAPESSVRTEASPSAGSDLEPENTT-LRDPAPNAIPPPE 477
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 598 PPPGLSHPSQVSAALDrrpSNGAEIKETGKENEALPDKRGEPFLQSRKSSNQATSSAPKT 657
Cdd:COG5665 478 DPSTIGRLSSGDKLAN---ETGPPVIRRDSTPSSTADQSIVGVLAFGLDQRTQAEISVEA 534
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
421-604 |
7.38e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 41.00 E-value: 7.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 421 PSSPVQTPSSPPhkPELPPSDSETASSVATAPTPSIPASTEESADAPSPLAEPSLtkaitpepessepekssspppqsls 500
Cdd:PRK07994 361 PAAPLPEPEVPP--QSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAV------------------------- 413
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 501 gsltQHEKAVNGLTDVDAAPLSEELETQPREASPllptssVPQSEPRPVTPVLEE--ESDPINMDSPLPPVEDDAGCPDN 578
Cdd:PRK07994 414 ----PLPETTSQLLAARQQLQRAQGATKAKKSEP------AAASRARPVNSALERlaSVRPAPSALEKAPAKKEAYRWKA 483
|
170 180
....*....|....*....|....*.
gi 1207195306 579 VSPSLstsTTAAISTTPPAPPPGLSH 604
Cdd:PRK07994 484 TNPVE---VKKEPVATPKALKKALEH 506
|
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| PHA03291 |
PHA03291 |
envelope glycoprotein I; Provisional |
395-469 |
8.16e-03 |
|
envelope glycoprotein I; Provisional
Pssm-ID: 223033 [Multi-domain] Cd Length: 401 Bit Score: 40.71 E-value: 8.16e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207195306 395 PKLEFSLQRTASPGLRQPDTPLERRDPSSPVQTPSSPPHKPELPPSDSETASSVATAPTPSIPASTEESADAPSP 469
Cdd:PHA03291 188 PALPLSAPRLGPADVFVPATPRPTPRTTASPETTPTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEGTPAPPTP 262
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
348-624 |
8.41e-03 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 40.83 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 348 PPVGrPSSTPTPPQQLNSQVADHGHimynvdsspHLPApfnlKADDKPKLEFSLQRTASPGLRQPDTPLERRDPSS-PVQ 426
Cdd:PTZ00449 510 PPEG-PEASGLPPKAPGDKEGEEGE---------HEDS----KESDEPKEGGKPGETKEGEVGKKPGPAKEHKPSKiPTL 575
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 427 T--PSSP-----PHKPELP--PSDSETASSVATAPTPS------IPASTEESADAPSPLAEPSLTKAITPEPESSEPEKS 491
Cdd:PTZ00449 576 SkkPEFPkdpkhPKDPEEPkkPKRPRSAQRPTRPKSPKlpelldIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIK 655
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195306 492 SSPPPQSLSGSL----------TQHEKAVNGLTDVDAAPLSEELETQPREASPLLPTSsvPQSEPRPVTPVLeeesdPIN 561
Cdd:PTZ00449 656 SPKPPKSPKPPFdpkfkekfydDYLDAAAKSKETKTTVVLDESFESILKETLPETPGT--PFTTPRPLPPKL-----PRD 728
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207195306 562 MDSPL-PPVEDDAGCPDNVSPSLSTSTTAAISTTPPAPPPglshPSQVSAALDRRPSNGAEIKE 624
Cdd:PTZ00449 729 EEFPFePIGDPDAEQPDDIEFFTPPEEERTFFHETPADTP----LPDILAEEFKEEDIHAETGE 788
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