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Conserved domains on  [gi|1207195218|ref|XP_021330181|]
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glucose-6-phosphate 1-dehydrogenase isoform X4 [Danio rerio]

Protein Classification

glucose-6-phosphate 1-dehydrogenase( domain architecture ID 1000188)

glucose-6-phosphate 1-dehydrogenase (G6PD) catalyzes the first and rate-limiting step of the oxidative branch within the pentose phosphate pathway/shunt, an alternative route to glycolysis for the dissimilation of carbohydrates and a major source of reducing power and metabolic intermediates for fatty acid and nucleic acid biosynthetic processes

EC:  1.1.1.-
Gene Ontology:  GO:0006006|GO:0050661|GO:0016614

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 27-513 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 695.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  27 SDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLT--VDAIRIACMPYMKVVDNEAERLAAFFSRNS 104
Cdd:PTZ00309   52 SRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHIS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 105 YISGKYVEESSFSDLNTHLLSLPGGAEA-----NRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSE 179
Cdd:PTZ00309  132 YISGSYDEDEDFKRLNKLIERMEEAFQGpekggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSE 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 180 ELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 259
Cdd:PTZ00309  212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 260 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGegeAKLGYLDDKTVPKGSTQATFATAV 339
Cdd:PTZ00309  292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADG---SIPGYLEDEGVPKDSTTPTFAAAV 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 340 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQ-CRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 418
Cdd:PTZ00309  369 LHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDdTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTEL 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 419 DLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVG 498
Cdd:PTZ00309  449 DLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527

                         490
                  ....*....|....*
gi 1207195218 499 FRYEGTYKWVNPHKL 513
Cdd:PTZ00309  528 FKSSKGYQWLQSNDQ 542
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 27-513 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 695.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  27 SDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLT--VDAIRIACMPYMKVVDNEAERLAAFFSRNS 104
Cdd:PTZ00309   52 SRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHIS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 105 YISGKYVEESSFSDLNTHLLSLPGGAEA-----NRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSE 179
Cdd:PTZ00309  132 YISGSYDEDEDFKRLNKLIERMEEAFQGpekggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSE 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 180 ELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 259
Cdd:PTZ00309  212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 260 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGegeAKLGYLDDKTVPKGSTQATFATAV 339
Cdd:PTZ00309  292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADG---SIPGYLEDEGVPKDSTTPTFAAAV 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 340 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQ-CRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 418
Cdd:PTZ00309  369 LHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDdTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTEL 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 419 DLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVG 498
Cdd:PTZ00309  449 DLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527

                         490
                  ....*....|....*
gi 1207195218 499 FRYEGTYKWVNPHKL 513
Cdd:PTZ00309  528 FKSSKGYQWLQSNDQ 542
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 30-504 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 667.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  30 HIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIR-IACMPYMKV-VDNEAERLAAFFSRNSYIS 107
Cdd:TIGR00871   3 CILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRkVVREAIIKFeTDEIDEQWDEFAQRLSYVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 108 GKYVEESSFSDLNTHLLSL--PGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKG-WNRVIVEKPFGRDLQSSEELSSH 184
Cdd:TIGR00871  83 GDVDDDESYDSLAELLEQLdkTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNKA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 185 LSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 264
Cdd:TIGR00871 163 LRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQ 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 265 MLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSD--VVLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAVLYV 342
Cdd:TIGR00871 243 LLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIG-GVSVPGYLEEEGVDKDSNTETFAALKLEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 343 KNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCR----RNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 418
Cdd:TIGR00871 322 DNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdanpRNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKL 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 419 DLTYHSRYRDVkLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIK-YKYGSRGPAEADELVQKV 497
Cdd:TIGR00871 402 DFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPSPPnYPAGSWGPKEADELIRKD 480


                  ....*..
gi 1207195218 498 GFRYEGT 504
Cdd:TIGR00871 481 GRSWRKP 487
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 31-510 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 516.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  31 IFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDA----IRIACMPYMKVVDNEAErLAAFFSRNSYI 106
Cdd:COG0364    11 DLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEfreeVREALEEFSRKPFDEEV-WERFLERLHYV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 107 SGKYVEESSFSDLNTHLLSLPG-GAEANRLFYLALPPSVYHDVTKNIKHQCMST-KGWNRVIVEKPFGRDLQSSEELSSH 184
Cdd:COG0364    90 SGDFTDPEGYERLKELLEELDEeRTPGNRVFYLATPPSLFGPICENLGAAGLATeGGWRRVVIEKPFGHDLASARELNDE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 185 LSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 264
Cdd:COG0364   170 LGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLLQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 265 MLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDV----VLGQYVGdpdGE--GEAKLGYLDDKTVPKGSTQATFATA 338
Cdd:COG0364   250 LLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTA---GWigGEPVPGYREEPGVAPDSTTETFVAL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 339 VLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRR---NELVVRVQPNEAIYAKMMSKKPGVYFSPEE 415
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMRLRP 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 416 TELDLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQ 495
Cdd:COG0364   407 VSLDFSYSDAF-GERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLA 485

                         490
                  ....*....|....*
gi 1207195218 496 KVGFRyegtykWVNP 510
Cdd:COG0364   486 RDGRS------WREP 494
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
210-501 7.18e-165

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 468.46  E-value: 7.18e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 210 MVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKV 289
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 290 LKCIEPVTLSDV----VLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKA 365
Cdd:pfam02781  81 LRSLRPITPEDVednvVRGQYGAGWIG-GEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 366 EVRLQFTDVPGDIF--SSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYrDVKLPDAYERLILDVF 443
Cdd:pfam02781 160 EIRIQFKDVPHNLFrdPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRF-GERIPEAYERLLLDVM 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207195218 444 CGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPikYKYGSRGPAEADELVQKVGFRY 501
Cdd:pfam02781 239 RGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPP--YPAGSWGPKAADELLARDGRKW 294
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 27-513 0e+00

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 695.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  27 SDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLT--VDAIRIACMPYMKVVDNEAERLAAFFSRNS 104
Cdd:PTZ00309   52 SRALTIIVLGASGDLAKKKTFPALFQLYCEGLLPSEVNIVGYARSKMSdvERWKKETLARFFKRLDDRECHLEQFLKHIS 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 105 YISGKYVEESSFSDLNTHLLSLPGGAEA-----NRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSE 179
Cdd:PTZ00309  132 YISGSYDEDEDFKRLNKLIERMEEAFQGpekggNRLFYLALPPSVFASVCEGIHRGCMSKNGWVRVIVEKPFGRDLESSE 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 180 ELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 259
Cdd:PTZ00309  212 ELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANRVFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGIIRDVMQ 291

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 260 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGegeAKLGYLDDKTVPKGSTQATFATAV 339
Cdd:PTZ00309  292 NHLLQILALLAMEKPVSLSAEDIRDEKVKVLKCIEPIKMEECVLGQYTASADG---SIPGYLEDEGVPKDSTTPTFAAAV 368

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 340 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQ-CRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 418
Cdd:PTZ00309  369 LHINNDRWEGVPFILEAGKALEERYVEIRIQFKGVDEFRPSGDdTQRNELVIRAQPSEAMYLKITAKVPGLSNDLHQTEL 448

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 419 DLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVG 498
Cdd:PTZ00309  449 DLTYKTRY-NVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTPLLHQIDRGEVKPEPYPFGSRGPKEADELIKKNG 527

                         490
                  ....*....|....*
gi 1207195218 499 FRYEGTYKWVNPHKL 513
Cdd:PTZ00309  528 FKSSKGYQWLQSNDQ 542
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 30-504 0e+00

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 667.87  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  30 HIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIR-IACMPYMKV-VDNEAERLAAFFSRNSYIS 107
Cdd:TIGR00871   3 CILVIFGASGDLARKKLFPALYRLFRNGLLPPDFRIVGVARRDWSVEEFRkVVREAIIKFeTDEIDEQWDEFAQRLSYVS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 108 GKYVEESSFSDLNTHLLSL--PGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKG-WNRVIVEKPFGRDLQSSEELSSH 184
Cdd:TIGR00871  83 GDVDDDESYDSLAELLEQLdkTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGkWSRVVVEKPFGHDLASAQELNKA 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 185 LSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 264
Cdd:TIGR00871 163 LRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQIFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGALRDMVQNHLLQ 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 265 MLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSD--VVLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAVLYV 342
Cdd:TIGR00871 243 LLALVAMEPPVSFDADSIRDEKVKVLKALRPIDPDDnnTVRGQYGAGEIG-GVSVPGYLEEEGVDKDSNTETFAALKLEI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 343 KNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCR----RNELVVRVQPNEAIYAKMMSKKPGVYFSPEETEL 418
Cdd:TIGR00871 322 DNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKANERdanpRNALVIRIQPDEGVYLKFNAKKPGLNFETRPVKL 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 419 DLTYHSRYRDVkLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIK-YKYGSRGPAEADELVQKV 497
Cdd:TIGR00871 402 DFSYASRFGEL-LPEAYERLLLDALLGDHTLFARDDEVEEAWRIVTPILEAWAANKGPSPPnYPAGSWGPKEADELIRKD 480


                  ....*..
gi 1207195218 498 GFRYEGT 504
Cdd:TIGR00871 481 GRSWRKP 487
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 33-500 0e+00

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 627.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  33 IIMGASGDLAKKKIYPTLWWLFRDGLL-PEQTYFVGFARSDLTVDAIRIACMPYMKVVDNE-AERLAAFFSRNSYISGKY 110
Cdd:PLN02539   21 IVLGASGDLAKKKTFPALFNLYRQGFLpPDEVHIFGYARSKITDEELRDRIRGYLKDEKNApAEAVSKFLQLIKYVSGAY 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 111 VEESSFSDLNTHLLSLP---GGAE--ANRLFYLALPPSVYHDVTKNIKHQCMSTKG-WNRVIVEKPFGRDLQSSEELSSH 184
Cdd:PLN02539  101 DSEEGFRRLDKEISEHEiskNSAEgsSRRLFYLALPPSVYPPVCKMIKKCCMNKSGlWTRIVVEKPFGKDLESAEELSSQ 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 185 LSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 264
Cdd:PLN02539  181 IGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLPLWNRDNIANVQIVFREDFGTEGRGGYFDEYGIIRDIIQNHLLQ 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 265 MLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVgdpdgegeaklGYLDDKTVPKGSTQATFATAVLYVKN 344
Cdd:PLN02539  261 VLCLVAMEKPVSLKPEHIRDEKVKVLQSVEPIKDEEVVLGQYE-----------GYRDDPTVPDDSNTPTFASVVLRINN 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 345 ERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCR-RNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYH 423
Cdd:PLN02539  330 ERWEGVPFILKAGKALDSRKAEIRVQFKDVPGDIFKCQKQgRNEFVIRLQPSEAMYMKLTVKQPGLEMSTVQSELDLSYG 409

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207195218 424 SRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVGFR 500
Cdd:PLN02539  410 QRYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTPLLHRIDAGKVKPIPYKQGSRGPAEADELLEKAGYV 486
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 31-510 0e+00

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 517.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  31 IFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDA----IRIACMPYMKVVDNEAErLAAFFSRNSYI 106
Cdd:PRK05722   11 DLVIFGATGDLARRKLLPALYNLYKAGLLPEDFRIIGVARRDWSDEDfrevVREALKEFARTPFDEEV-WERFLSRLYYV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 107 SGKYVEESSFSDLNTHLLSLPG--GAEANRLFYLALPPSVYHDVTKNIK-HQCMSTKGWNRVIVEKPFGRDLQSSEELSS 183
Cdd:PRK05722   90 SGDVTDPESYERLKELLEELDEerGTGGNRVFYLATPPSLFGTICENLAaAGLNEGGGWRRVVIEKPFGHDLASARELND 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 184 HLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLL 263
Cdd:PRK05722  170 QVGEVFKEEQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGALRDMVQNHLL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 264 QMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDV----VLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAV 339
Cdd:PRK05722  250 QLLALVAMEPPASLDADSIRDEKVKVLRALRPITPEDVkentVRGQYTAGWIG-GKPVPGYREEEGVNPDSTTETFVALK 328

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 340 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSS---QCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEET 416
Cdd:PRK05722  329 LEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFKPPPHNLFEEsaeELGPNKLVIRIQPDEGISLRFNAKVPGEGMELRPV 408

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 417 ELDLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQK 496
Cdd:PRK05722  409 KLDFSYSEAF-GEASPEAYERLLLDVMLGDQTLFVRRDEVEAAWKWVDPILEAWEADGGPPPPYPAGTWGPEAADALLAR 487

                         490
                  ....*....|....
gi 1207195218 497 VGFRyegtykWVNP 510
Cdd:PRK05722  488 DGRS------WREP 495
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 31-510 0e+00

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 516.93  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  31 IFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDA----IRIACMPYMKVVDNEAErLAAFFSRNSYI 106
Cdd:COG0364    11 DLVIFGATGDLARRKLLPALYNLYRDGLLPEGFRIIGVARRDWSDEEfreeVREALEEFSRKPFDEEV-WERFLERLHYV 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 107 SGKYVEESSFSDLNTHLLSLPG-GAEANRLFYLALPPSVYHDVTKNIKHQCMST-KGWNRVIVEKPFGRDLQSSEELSSH 184
Cdd:COG0364    90 SGDFTDPEGYERLKELLEELDEeRTPGNRVFYLATPPSLFGPICENLGAAGLATeGGWRRVVIEKPFGHDLASARELNDE 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 185 LSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQ 264
Cdd:COG0364   170 LGRVFDESQIYRIDHYLGKETVQNLLALRFANALFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGALRDMVQNHLLQ 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 265 MLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDV----VLGQYVGdpdGE--GEAKLGYLDDKTVPKGSTQATFATA 338
Cdd:COG0364   250 LLCLVAMEPPASLDADAIRDEKVKVLRALRPITPEDVaentVRGQYTA---GWigGEPVPGYREEPGVAPDSTTETFVAL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 339 VLYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRR---NELVVRVQPNEAIYAKMMSKKPGVYFSPEE 415
Cdd:COG0364   327 KLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKPVPHSLFRETAEElppNRLVIRIQPDEGISLRFNAKVPGLGMRLRP 406

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 416 TELDLTYHSRYrDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQ 495
Cdd:COG0364   407 VSLDFSYSDAF-GERSPEAYERLLLDVMRGDQTLFMRRDEVEAAWRWVDPILEAWAEEPEPPPPYPAGSWGPEAADALLA 485

                         490
                  ....*....|....*
gi 1207195218 496 KVGFRyegtykWVNP 510
Cdd:COG0364   486 RDGRS------WREP 494
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 34-501 8.96e-177

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 509.56  E-value: 8.96e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  34 IMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIR------IACMpyMKVVDNEAERLAAFFSRNSYIS 107
Cdd:PLN02640   93 VVGASGDLAKKKIFPALFALFYEDWLPENFTVFGYARTKLTDEELRdmisstLTCR--IDQRENCGDKMDQFLKRCFYHS 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 108 GKYVEESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSEELSSHLSS 187
Cdd:PLN02640  171 GQYDSEEDFAELNKKLKEKEAGKLSNRLFYLSIPPNIFVDVVRCASLRASSENGWTRVIVEKPFGRDSESSGELTRCLKQ 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 188 LFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLS 267
Cdd:PLN02640  251 YLTEEQIFRIDHYLGKELVENLSVLRFSNLVFEPLWSRNYIRNVQLIFSEDFGTEGRGGYFDNYGIIRDIMQNHLLQILA 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 268 LVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAVLYVKNERW 347
Cdd:PLN02640  331 LFAMETPVSLDAEDIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKG-GKSYPAYTDDPTVPKHSLTPTFAAAALFINNARW 409

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 348 DGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQC------RRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLT 421
Cdd:PLN02640  410 DGVPFLMKAGKALHTRRAEIRVQFRHVPGNLYKRNFgtdldkATNELVLRVQPDEAIYLKINNKVPGLGMRLDRSDLNLL 489

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 422 YHSRY-RDVklPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKVGFR 500
Cdd:PLN02640  490 YRARYpREI--PDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPELYPYGSRGPVGAHYLAAKYNVR 567


                  .
gi 1207195218 501 Y 501
Cdd:PLN02640  568 W 568
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 26-501 7.70e-174

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 502.97  E-value: 7.70e-174
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  26 QSDVHIFIImGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIR------IACMpyMKVVDNEAERLAAF 99
Cdd:PLN02333  115 ESTVSITVV-GASGDLAKKKIFPALFALYYEGCLPEHFTIFGYARSKMTDAELRnmvsktLTCR--IDKRENCGEKMEEF 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 100 FSRNSYISGKYVEESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMSTKGWNRVIVEKPFGRDLQSSE 179
Cdd:PLN02333  192 LKRCFYHSGQYDSQEHFAELDKKLKEHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASSVNGWTRVIVEKPFGRDSESSA 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 180 ELSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQ 259
Cdd:PLN02333  272 ALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNLIFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDIMQ 351

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 260 NHLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAV 339
Cdd:PLN02333  352 NHLLQILALFAMETPVSLDAEDIRNEKVKVLRSMRPIQLEDVVIGQYKSHTKG-GVTYPAYTDDKTVPKGSLTPTFAAAA 430

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 340 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDI----FSSQCRR--NELVVRVQPNEAIYAKMMSKKPGVYFSP 413
Cdd:PLN02333  431 LFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRHVPGNLynrnFGTDLDQatNELVIRVQPDEAIYLKINNKVPGLGMRL 510

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 414 EETELDLTYHSRYRDvKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADEL 493
Cdd:PLN02333  511 DRSNLNLLYAARYSK-EIPDAYERLLLDAIEGERRLFIRSDELDAAWALFTPLLKELEEKKIIPEYYPYGSRGPVGAHYL 589


                  ....*...
gi 1207195218 494 VQKVGFRY 501
Cdd:PLN02333  590 AARYKVRW 597
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
210-501 7.18e-165

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 468.46  E-value: 7.18e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 210 MVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNHLLQMLSLVAMEKPASTSSDDVRDEKVKV 289
Cdd:pfam02781   1 LVLRFANAIFEPLWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAEDIRDEKVKV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 290 LKCIEPVTLSDV----VLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAVLYVKNERWDGVPFILRCGKALNERKA 365
Cdd:pfam02781  81 LRSLRPITPEDVednvVRGQYGAGWIG-GEPVPGYREEEGVPPDSRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 366 EVRLQFTDVPGDIF--SSQCRRNELVVRVQPNEAIYAKMMSKKPGVYFSPEETELDLTYHSRYrDVKLPDAYERLILDVF 443
Cdd:pfam02781 160 EIRIQFKDVPHNLFrdPGTLPPNELVIRIQPDEGIYLKFNAKVPGLGMRLRPVELDFSYSDRF-GERIPEAYERLLLDVM 238

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1207195218 444 CGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPikYKYGSRGPAEADELVQKVGFRY 501
Cdd:pfam02781 239 RGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPP--YPAGSWGPKAADELLARDGRKW 294
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
26-511 5.86e-159

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 460.52  E-value: 5.86e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  26 QSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDA----IRIACMPYMKVVDNEAeRLAAFFS 101
Cdd:PRK12853    5 PAPPCTLVIFGATGDLARRKLLPALYRLARAGLLPEDLRIIGVGRDDWSDEQwrarVRESLRAFGADGFDDA-VWDRLAA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 102 RNSYISGKYVEESSFSDLNTHLlslpgGAEANRLFYLALPPSVYHDVTKNIKHQCMsTKGWNRVIVEKPFGRDLQSSEEL 181
Cdd:PRK12853   84 RLSYVQGDVTDPADYARLAEAL-----GPGGNPVFYLAVPPSLFAPVVENLGAAGL-LPEGRRVVLEKPFGHDLASARAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 182 SSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQNH 261
Cdd:PRK12853  158 NATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANALLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRDMVQNH 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 262 LLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDV--VLGQYVGDPDGeGEAKLGYLDDKTVPKGSTQATFATAV 339
Cdd:PRK12853  238 LLQLLALVAMEPPASFDADAVRDEKAKVLRAIRPLDPDDVhtVRGQYTAGTVG-GEPVPGYREEPGVDPDSRTETFVALK 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 340 LYVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIFSSQCRR--NELVVRVQPNEAIYAKMMSKKPGVYFSPEETE 417
Cdd:PRK12853  317 LEIDNWRWAGVPFYLRTGKRLAERRTEIVITFKPVPHALFRGTGVEppNRLVIRLQPDEGISLELNVKRPGPGMRLRPVE 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 418 LDLTYHSRYRDvklPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHQIESEKTPPIKYKYGSRGPAEADELVQKV 497
Cdd:PRK12853  397 LDADYADDERP---LEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDAWAADPVPPHEYPAGSWGPAAADALLARD 473

                         490
                  ....*....|....
gi 1207195218 498 GFRyegtykWVNPH 511
Cdd:PRK12853  474 GRG------WREPA 481
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 26-507 6.06e-120

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 360.89  E-value: 6.06e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  26 QSDVHIFIIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDA----IRIACMPYMKVVDNEAErLAAFFS 101
Cdd:PRK12854    8 PAPPTVFVLFGATGDLAKRKLLPGLFHLARAGLLPPDWRIVGTGRGDVSAEAfrehARDALDEFGARKLDDGE-WARFAK 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 102 RNSYISGKYVEESSFSDLNT-HLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMsTKGwNRVIVEKPFGRDLQSSEE 180
Cdd:PRK12854   87 RLRYVPGGFLSAGPGALAAAvAAARAELGGDARLVHYLAVPPSAFLDVTRALGEAGL-AEG-SRVVMEKPFGTDLASAEA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 181 LSSHLSSLFTEEQIYRIDHYLGKEMVQNLMVLRFGNRIFGPIWNRDSVACVVLTFKEPFGTQGRGGYFDDFGIIRDVMQN 260
Cdd:PRK12854  165 LNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANGLFEPIWNREFIDHVQIDVPETLGVDTRAAFYDATGAYRDMVVT 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 261 HLLQMLSLVAMEKPASTSSDDVRDEKVKVLKCIEPVTLSDVVLGQYVgdpdgegeaklGYLDDKTVPKGSTQATFATAVL 340
Cdd:PRK12854  245 HLFQVLAFVAMEPPTALEPDAISEEKNKVFRSMRPLDPAEVVRGQYS-----------GYRDEPGVAPDSTTETFVALKV 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 341 YVKNERWDGVPFILRCGKALNERKAEVRLQFTDVPGDIF--SSQCRR--NELVVRVQPNEAIYAKMMSKKPGVYFSPEET 416
Cdd:PRK12854  314 WIDNWRWAGVPFYLRTGKRMAEGQRIISIAFREPPYSMFpaGSVGAQgpDHLTFDLADNSKVSLSFYGKRPGPGMRLDKL 393

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 417 ELDLTYHSRYRDVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLhqiesEKTPPIK-YKYGSRGPAEADELVQ 495
Cdd:PRK12854  394 SLQFSLKDTGPKGDVLEAYERLILDALRGDHTLFTTADGIESLWEVSQPLL-----EDPPPVKpYAPGSWGPNAIHQLAA 468

                         490
                  ....*....|..
gi 1207195218 496 KVGFRYEGTYKW 507
Cdd:PRK12854  469 PDAWRLPFEREW 480
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
33-208 1.05e-77

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 241.17  E-value: 1.05e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218  33 IIMGASGDLAKKKIYPTLWWLFRDGLLPEQTYFVGFARSDLTVDAIRIACMPYMKVVDN-EAERLAAFFSRNSYISGKYV 111
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRDGLLPEGFRIIGVARRDLSDEEFRERVREALKEFKElDEEKWDRFLERLHYVSGDFD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207195218 112 EESSFSDLNTHLLSLPGGAEANRLFYLALPPSVYHDVTKNIKHQCMS-TKGWNRVIVEKPFGRDLQSSEELSSHLSSLFT 190
Cdd:pfam00479  81 DPESYEKLKERLEEHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSeEGGWRRVVIEKPFGHDLESARELNDQLAKVFK 160

                         170
                  ....*....|....*...
gi 1207195218 191 EEQIYRIDHYLGKEMVQN 208
Cdd:pfam00479 161 EEQIYRIDHYLGKETVQN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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