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Conserved domains on  [gi|1207194854|ref|XP_021330020|]
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leucine-rich repeat-containing protein 75A [Danio rerio]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 167-273 1.91e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194854 167 LKSVLSSPPSGGTLDLSGIPLGVKDMERLCAYLHHYASrIGSLELGFTELTDDAFLLLLPTLASLPRLETLALNGNRLTR 246
Cdd:COG5238   200 LAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGA 278

                          90       100
                  ....*....|....*....|....*..
gi 1207194854 247 AVLKELTDTLKDPdsfPSVTWIDLGNN 273
Cdd:COG5238   279 EGAIALAKALQGN---TTLTSLDLSVN 302
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 167-273 1.91e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194854 167 LKSVLSSPPSGGTLDLSGIPLGVKDMERLCAYLHHYASrIGSLELGFTELTDDAFLLLLPTLASLPRLETLALNGNRLTR 246
Cdd:COG5238   200 LAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGA 278

                          90       100
                  ....*....|....*....|....*..
gi 1207194854 247 AVLKELTDTLKDPdsfPSVTWIDLGNN 273
Cdd:COG5238   279 EGAIALAKALQGN---TTLTSLDLSVN 302
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 170-259 1.35e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194854 170 VLSSPPSGGTLDLSGIPLGVKDMERLCAYLHHYASRIGSLELGFTELTDDAFLLLLPTLASLPRLETLALNGNRLTRAVL 249
Cdd:cd00116   216 TLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295

                          90
                  ....*....|
gi 1207194854 250 KELTDTLKDP 259
Cdd:cd00116   296 QLLAESLLEP 305
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 167-273 1.91e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 46.71  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194854 167 LKSVLSSPPSGGTLDLSGIPLGVKDMERLCAYLHHYASrIGSLELGFTELTDDAFLLLLPTLASLPRLETLALNGNRLTR 246
Cdd:COG5238   200 LAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKS-LTTLDLSNNQIGDEGVIALAEALKNNTTVETLYLSGNQIGA 278

                          90       100
                  ....*....|....*....|....*..
gi 1207194854 247 AVLKELTDTLKDPdsfPSVTWIDLGNN 273
Cdd:COG5238   279 EGAIALAKALQGN---TTLTSLDLSVN 302
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 170-259 1.35e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.42  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207194854 170 VLSSPPSGGTLDLSGIPLGVKDMERLCAYLHHYASRIGSLELGFTELTDDAFLLLLPTLASLPRLETLALNGNRLTRAVL 249
Cdd:cd00116   216 TLASLKSLEVLNLGDNNLTDAGAAALASALLSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGA 295

                          90
                  ....*....|
gi 1207194854 250 KELTDTLKDP 259
Cdd:cd00116   296 QLLAESLLEP 305
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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