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Conserved domains on  [gi|1207190900|ref|XP_021328422|]
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centromere protein F isoform X2 [Danio rerio]

Protein Classification

kinesin family protein; PEPP family PH domain-containing protein( domain architecture ID 13172616)

kinesin family protein is a microtubule-dependent molecular motor that plays an important role in intracellular transport and in cell division and has an ATPase-containing motor domain; similar to N-type kinesins that are (+) end-directed motors and have an N-terminal motor domain| PEPP (phosphoinositol 3-phosphate-binding protein) family PH (pleckstrin homology) domain-containing protein similar to PH domain region of vertebrate pleckstrin homology domain-containing family A member 4/5/6/7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CENP-F_N super family cl25738
Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound ...
 1-270 1.92e-31

Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein.


The actual alignment was detected with superfamily member pfam10481:

Pssm-ID: 463106 [Multi-domain]  Cd Length: 304  Bit Score: 126.09  E-value: 1.92e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900    1 MSWAGDDWTVGLTGHVLQKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELGGVREAAQAEV 80
Cdd:pfam10481    1 MSWAVEEWKEGLPTKALQKIQELESQLDKLKKERQQKQFQLESLEAALQKQKQKVENEKNEGSALKRENQSLMESCDNLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   81 RTRERLSHDLQVKTGQVHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTL---------FSTPCWNTSSPW 151
Cdd:pfam10481   81 KSRQKISHDLQVKESQVNFLEGQLNSSKKQIEKLEQELKRYKSELERSQQALLAGDVSLqpcstpqksFATPLTPSQRHN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  152 DNNGGFRAESESKAQHARQLQFGDVPKPSAGGASSPFPQQPYKSPPLRRHvrqsepSTPSSVFPWERD------------ 219
Cdd:pfam10481  161 DSKYEELQEKYNKEVEERKRLEAELKVLQVKKTNQTLPQSTVSHRDIARH------QASSSVFPWQQEktpsrqssdaqe 234

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190900  220 -----------VLW---STPKGRPTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQ 270
Cdd:pfam10481  235 tplkrgftashFLWeheETPSKRSQRSSSNSSLQSNSSSSQLMDQLKAQNQELRSRVSELELRLQ 299
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 249-785 1.21e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 92.69  E-value: 1.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHL 328
Cdd:COG1196    270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAEssrcNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQhdkvclqkQ 408
Cdd:COG1196    350 EEELEEAEAELA----EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL--------E 417

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  409 SLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEAlKLIKELQ 488
Cdd:COG1196    418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA-AARLLLL 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  489 AQLAASPPPVAAPNFSSAGDSFSPCVSLHHDRsspfnNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEHIDKfese 568
Cdd:COG1196    497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAV-----LIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK---- 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  569 eksQKRIGVQT-LPSGSLKLTEF-DLDTSVMEQDTGIEDVDTDSFTSDSTRgtmpKSESDISRSLKLDNTSGKTEKYDST 646
Cdd:COG1196    568 ---AAKAGRATfLPLDKIRARAAlAAALARGAIGAAVDLVASDLREADARY----YVLGDTLLGRTLVAARLEAALRRAV 640

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  647 TLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEK 726
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  727 KESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDL 785
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
CENP-F_C_Rb_bdg super family cl11130
Rb-binding domain of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, ...
 1632-1677 8.81e-18

Rb-binding domain of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains.


The actual alignment was detected with superfamily member pfam10490:

Pssm-ID: 463111  Cd Length: 47  Bit Score: 78.26  E-value: 8.81e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1207190900 1632 SAAYDETEYEPYGLPEVVMKGFADIPSGPACPYVLRRGLLGTDAMP 1677
Cdd:pfam10490    2 RAEQDDEEFEPEGLPEVVQKGFADIPSGEVSPYILRRTTLQLRCSP 47
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 660-1000 6.89e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.19  E-value: 6.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  660 DELRDVKYDLQKRLEDLETQRRA-------ETEARTKLKQLS----RKHSTQTEQQRAKALELKDSLVKLETQLEQEKKE 728
Cdd:COG1196    189 ERLEDILGELERQLEPLERQAEKaeryrelKEELKELEAELLllklRELEAELEELEAELEELEAELEELEAELAELEAE 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  729 SSKLKETLHALQSEAENRkvndQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEERKLIR 808
Cdd:COG1196    269 LEELRLELEELELELEEA----QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  809 REEGLKIAQLQEELDILRKSTGLEEKISKdnlpltylhlehhQNTDQKADLTENKDLIpspgvqefsvNLQNTMVRNEAK 888
Cdd:COG1196    345 ELEEAEEELEEAEAELAEAEEALLEAEAE-------------LAEAEEELEELAEELL----------EALRAAAELAAQ 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  889 TIELIMDLEAQTKpktspsdmNRARALSTEASDLDNstvlVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLT 968
Cdd:COG1196    402 LEELEEAEEALLE--------RLERLEEELEELEEA----LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1207190900  969 QAFESQSKHIDNLLSELEDKECALQKQAEELQ 1000
Cdd:COG1196    470 EEAALLEAALAELLEELAEAAARLLLLLEAEA 501
PRK11281 super family cl46976
mechanosensitive channel MscK;
1060-1311 2.53e-03

mechanosensitive channel MscK;


The actual alignment was detected with superfamily member PRK11281:

Pssm-ID: 481316 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1060 EKVSEHTVQLPVEASVIQNIDQTNT--SEISDKLQATEHFKQQsvdtsnsstASDAPI-ISDVTEEKSSsvLQDEQLNVV 1136
Cdd:PRK11281    46 DALNKQKLLEAEDKLVQQDLEQTLAllDKIDRQKEETEQLKQQ---------LAQAPAkLRQAQAELEA--LKDDNDEET 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1137 NCQNDSIPehsihdIKELER----VTKELQAAQLELNVM------------KAQN--SELALQGDMIKDKLLNVQQENQE 1198
Cdd:PRK11281   115 RETLSTLS------LRQLESrlaqTLDQLQNAQNDLAEYnsqlvslqtqpeRAQAalYANSQRLQQIRNLLKGGKVGGKA 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1199 LKSTLKHLCEdtgAKQDgALNLANSKNKSLLSSNEGLQSISPLGKEKLVVQHGNSEAEVQSLQEQIqklQDQILDLFEQn 1278
Cdd:PRK11281   189 LRPSQRVLLQ---AEQA-LLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQEAI---NSKRLTLSEK- 260

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1207190900 1279 rtQAEQLElwklsTVEETAGNNSPSIVLKEFEL 1311
Cdd:PRK11281   261 --TVQEAQ-----SQDEAARIQANPLVAQELEI 286
 
Name Accession Description Interval E-value
CENP-F_N pfam10481
Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound ...
 1-270 1.92e-31

Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein.


Pssm-ID: 463106 [Multi-domain]  Cd Length: 304  Bit Score: 126.09  E-value: 1.92e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900    1 MSWAGDDWTVGLTGHVLQKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELGGVREAAQAEV 80
Cdd:pfam10481    1 MSWAVEEWKEGLPTKALQKIQELESQLDKLKKERQQKQFQLESLEAALQKQKQKVENEKNEGSALKRENQSLMESCDNLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   81 RTRERLSHDLQVKTGQVHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTL---------FSTPCWNTSSPW 151
Cdd:pfam10481   81 KSRQKISHDLQVKESQVNFLEGQLNSSKKQIEKLEQELKRYKSELERSQQALLAGDVSLqpcstpqksFATPLTPSQRHN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  152 DNNGGFRAESESKAQHARQLQFGDVPKPSAGGASSPFPQQPYKSPPLRRHvrqsepSTPSSVFPWERD------------ 219
Cdd:pfam10481  161 DSKYEELQEKYNKEVEERKRLEAELKVLQVKKTNQTLPQSTVSHRDIARH------QASSSVFPWQQEktpsrqssdaqe 234

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190900  220 -----------VLW---STPKGRPTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQ 270
Cdd:pfam10481  235 tplkrgftashFLWeheETPSKRSQRSSSNSSLQSNSSSSQLMDQLKAQNQELRSRVSELELRLQ 299
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 249-785 1.21e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 92.69  E-value: 1.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHL 328
Cdd:COG1196    270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAEssrcNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQhdkvclqkQ 408
Cdd:COG1196    350 EEELEEAEAELA----EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL--------E 417

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  409 SLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEAlKLIKELQ 488
Cdd:COG1196    418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA-AARLLLL 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  489 AQLAASPPPVAAPNFSSAGDSFSPCVSLHHDRsspfnNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEHIDKfese 568
Cdd:COG1196    497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAV-----LIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK---- 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  569 eksQKRIGVQT-LPSGSLKLTEF-DLDTSVMEQDTGIEDVDTDSFTSDSTRgtmpKSESDISRSLKLDNTSGKTEKYDST 646
Cdd:COG1196    568 ---AAKAGRATfLPLDKIRARAAlAAALARGAIGAAVDLVASDLREADARY----YVLGDTLLGRTLVAARLEAALRRAV 640

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  647 TLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEK 726
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  727 KESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDL 785
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
CENP-F_C_Rb_bdg pfam10490
Rb-binding domain of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, ...
 1632-1677 8.81e-18

Rb-binding domain of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains.


Pssm-ID: 463111  Cd Length: 47  Bit Score: 78.26  E-value: 8.81e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1207190900 1632 SAAYDETEYEPYGLPEVVMKGFADIPSGPACPYVLRRGLLGTDAMP 1677
Cdd:pfam10490    2 RAEQDDEEFEPEGLPEVVQKGFADIPSGEVSPYILRRTTLQLRCSP 47
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 247-994 9.89e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.12  E-value: 9.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  247 MEDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVK 326
Cdd:TIGR02168  254 ELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  327 HLQEELKCQRQNAESSRCNAEQRRKDMEREHQrELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQ 406
Cdd:TIGR02168  334 ELAEELAELEEKLEELKEELESLEAELEELEA-ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  407 KQSLERDLEDVKGKLKN-TEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIK 485
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKlEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  486 ELQAQLAASPPPVAAPNF----SSAGDSFSPCVS----------------LHHDRSSPF-NNSSQRKRA------PNTGR 538
Cdd:TIGR02168  493 SLERLQENLEGFSEGVKAllknQSGLSGILGVLSelisvdegyeaaieaaLGGRLQAVVvENLNAAKKAiaflkqNELGR 572

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  539 treeeRMKYPSGREPGEGIDSEHIDKFESEE------------KSQKRIGVQTLPSGSLKLTEFDLDTSV---MEQDTGI 603
Cdd:TIGR02168  573 -----VTFLPLDSIKGTEIQGNDREILKNIEgflgvakdlvkfDPKLRKALSYLLGGVLVVDDLDNALELakkLRPGYRI 647

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  604 EDVDTDSFTSD--STRGTMPKSESDISRSLKLDNTSGKTEKYDStTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRR 681
Cdd:TIGR02168  648 VTLDGDLVRPGgvITGGSAKTNSSILERRREIEELEEKIEELEE-KIAELEKALAELRKELEELEEELEQLRKELEELSR 726

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  682 AETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETlhalqseaenrKVNDQEEDSQLKKAL 761
Cdd:TIGR02168  727 QISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA-----------EAEIEELEAQIEQLK 795

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  762 AEMEQKETIMEEEmmgiKKELQDLQLKLAQEREEREQERLEERKLIRREEGL--KIAQLQEELdilrksTGLEEKISKDN 839
Cdd:TIGR02168  796 EELKALREALDEL----RAELTLLNEEAANLRERLESLERRIAATERRLEDLeeQIEELSEDI------ESLAAEIEELE 865

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  840 LPLTYLHLEHHQNTDQKADLTENKDLIPSpgvQEFSVNLQNTMVRNEAKTIELIMDlEAQTKPKTSPSDMNRARA-LSTE 918
Cdd:TIGR02168  866 ELIEELESELEALLNERASLEEALALLRS---ELEELSEELRELESKRSELRRELE-ELREKLAQLELRLEGLEVrIDNL 941

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  919 ASDLDNSTVLVLE-VERLRAARDRESEKAkvsQRKLEELQKQVttqtKQL-------TQAFESQSKHIDNLLSELEDKEC 990
Cdd:TIGR02168  942 QERLSEEYSLTLEeAEALENKIEDDEEEA---RRRLKRLENKI----KELgpvnlaaIEEYEELKERYDFLTAQKEDLTE 1014


                   ....
gi 1207190900  991 ALQK 994
Cdd:TIGR02168 1015 AKET 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 660-1000 6.89e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.19  E-value: 6.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  660 DELRDVKYDLQKRLEDLETQRRA-------ETEARTKLKQLS----RKHSTQTEQQRAKALELKDSLVKLETQLEQEKKE 728
Cdd:COG1196    189 ERLEDILGELERQLEPLERQAEKaeryrelKEELKELEAELLllklRELEAELEELEAELEELEAELEELEAELAELEAE 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  729 SSKLKETLHALQSEAENRkvndQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEERKLIR 808
Cdd:COG1196    269 LEELRLELEELELELEEA----QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  809 REEGLKIAQLQEELDILRKSTGLEEKISKdnlpltylhlehhQNTDQKADLTENKDLIpspgvqefsvNLQNTMVRNEAK 888
Cdd:COG1196    345 ELEEAEEELEEAEAELAEAEEALLEAEAE-------------LAEAEEELEELAEELL----------EALRAAAELAAQ 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  889 TIELIMDLEAQTKpktspsdmNRARALSTEASDLDNstvlVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLT 968
Cdd:COG1196    402 LEELEEAEEALLE--------RLERLEEELEELEEA----LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1207190900  969 QAFESQSKHIDNLLSELEDKECALQKQAEELQ 1000
Cdd:COG1196    470 EEAALLEAALAELLEELAEAAARLLLLLEAEA 501
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 248-972 1.95e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.68  E-value: 1.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLT---RTQEQLTRAQTRSTQETDRAQTAEQK 324
Cdd:pfam02463  295 EEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKeleIKREAEEEEEEELEKLQEKLEQLEEE 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  325 VKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLN--QEIQQARTLHNTLQAQHDK 402
Cdd:pfam02463  375 LLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEeeEESIELKQGKLTEEKEELE 454

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  403 V--------CLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESL-------------TVSLGQMKK 461
Cdd:pfam02463  455 KqelkllkdELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLlalikdgvggriiSAHGRLGDL 534

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  462 QEKVLQEEVKRLTEELAEALKLIKELQAQLAASPPPVAAPNF--------SSAGDSFSPCVSLHHDRSSPFNNSSQRKRA 533
Cdd:pfam02463  535 GVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGarklrlliPKLKLPLKSIAVLEIDPILNLAQLDKATLE 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  534 PNTGRTREEERMKYPSGREPGEGIDSEHIDKFESEEKSQKRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEDVDTDSFTS 613
Cdd:pfam02463  615 ADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEI 694

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  614 DSTRGTMPKSESDISRSLKLDNTSgKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQL 693
Cdd:pfam02463  695 LRRQLEIKKKEQREKEELKKLKLE-AEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKE 773

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  694 SRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEE 773
Cdd:pfam02463  774 KELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAE 853

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  774 EMmgiKKELQDLQLKLAQEREEREQERLEERKLIRREEGLKIAQLQEELDILRKSTGLEEKISKDNLPLTYLHLEHHQNT 853
Cdd:pfam02463  854 EE---LERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEIL 930

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  854 DQKADLTENKDLIPSPGVQEFSVNLQNTMVRNeaktielimDLEAQTKPKTSPSDMNRARAlsteasdldnstvlvlEVE 933
Cdd:pfam02463  931 LKYEEEPEELLLEEADEKEKEENNKEEEEERN---------KRLLLAKEELGKVNLMAIEE----------------FEE 985

                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 1207190900  934 RLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLTQAFE 972
Cdd:pfam02463  986 KEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLE 1024
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
253-765 2.73e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.00  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  253 NEIDELRVRVSDLQRE---AQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQ 329
Cdd:PRK03918   207 REINEISSELPELREElekLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  330 E----------------ELKCQRQNAESSRCNAEQRRKDMEREHQrELVEQQRERQALEKQHQQENNRLNQEIQQARTLH 393
Cdd:PRK03918   287 ElkekaeeyiklsefyeEYLDELREIEKRLSRLEEEINGIEERIK-ELEEKEERLEELKKKLKELEKRLEELEERHELYE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  394 NTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKV-------L 466
Cdd:PRK03918   366 EAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgreL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  467 QEE-----VKRLTEELAEALKLIKELQAQLAASPPpvaapnfssagdsfspcvslhhdrsspfnnssqRKRAPNTGRTRE 541
Cdd:PRK03918   446 TEEhrkelLEEYTAELKRIEKELKEIEEKERKLRK---------------------------------ELRELEKVLKKE 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  542 EERMKYPSGREPGEGIDSEhIDKFESEEKSQKRIGVQTLPSGSLKLTEfdlDTSVMEQD-TGIEDVDTDSFTSDSTRGTM 620
Cdd:PRK03918   493 SELIKLKELAEQLKELEEK-LKKYNLEELEKKAEEYEKLKEKLIKLKG---EIKSLKKElEKLEELKKKLAELEKKLDEL 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  621 PKSESDISRSLK---------LDNTSGKTEKY--DSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTK 689
Cdd:PRK03918   569 EEELAELLKELEelgfesveeLEERLKELEPFynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKE 648

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190900  690 LKQLSRKHSTQT-EQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKvNDQEEDSQLKKALAEME 765
Cdd:PRK03918   649 LEELEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE-KAKKELEKLEKALERVE 724
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 648-1108 1.64e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKYDLQKRLEDLETQ----RRAETEARTKLKQLSRKHSTQTEQQRakalELKDSLVKLETQLE 723
Cdd:pfam15921  319 LSDLESTVSQLRSELREAKRMYEDKIEELEKQlvlaNSELTEARTERDQFSQESGNLDDQLQ----KLLADLHKREKELS 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  724 QEKKESSKLKE-------TLHALQSEAENRKVNDQEEDSQLKKALAEMEQKetiMEEEMMGIKKELQDLQlKLAQEREER 796
Cdd:pfam15921  395 LEKEQNKRLWDrdtgnsiTIDHLRRELDDRNMEVQRLEALLKAMKSECQGQ---MERQMAAIQGKNESLE-KVSSLTAQL 470

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  797 EQERLEERKLIRREEGLKIAQLQEELDILRKSTGLEEK---ISKDNLPLTYL------------HL----EHHQNTDQKA 857
Cdd:pfam15921  471 ESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKeraIEATNAEITKLrsrvdlklqelqHLknegDHLRNVQTEC 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  858 DLTENKDLIPSPGVQEFSVNLQNTM--VRNEAKTIELIMDLEAQTKPKTSPSDMN-------------RARALSTEASDL 922
Cdd:pfam15921  551 EALKLQMAEKDKVIEILRQQIENMTqlVGQHGRTAGAMQVEKAQLEKEINDRRLElqefkilkdkkdaKIRELEARVSDL 630

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  923 DNSTVLVLEV--ERLRAARDRE--------------------SEKAKVSQRKLEELQKQVTTQTKQLTQAFESQSKHID- 979
Cdd:pfam15921  631 ELEKVKLVNAgsERLRAVKDIKqerdqllnevktsrnelnslSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEq 710

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  980 --NLLSELEDKECALQKQAEELQK-----------CQEKICFLEEKQTRTN-DLSAPPELSTEISRELSCDSVFSNTSIS 1045
Cdd:pfam15921  711 trNTLKSMEGSDGHAMKVAMGMQKqitakrgqidaLQSKIQFLEEAMTNANkEKHFLKEEKNKLSQELSTVATEKNKMAG 790

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900 1046 DHEMFSDDTPPvLKEKVSEHTVQL---PVEASVIQNIDQTNTSE-ISDKLQATEHFK--QQSVDTSNSS 1108
Cdd:pfam15921  791 ELEVLRSQERR-LKEKVANMEVALdkaSLQFAECQDIIQRQEQEsVRLKLQHTLDVKelQGPGYTSNSS 858
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 18-487 3.76e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 3.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   18 QKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELGGV---REAAQAEV----RTRERLSHDL 90
Cdd:COG1196    316 ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAeaeLAEAEEELeelaEELLEALRAA 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   91 QVKTGQVHSLEGQLESAKKLTQSLTQEIKRLEAEL-------------------------EKLQKGNGSGESTLFSTPCW 145
Cdd:COG1196    396 AELAAQLEELEEAEEALLERLERLEEELEELEEALaeleeeeeeeeealeeaaeeeaeleEEEEALLELLAELLEEAALL 475

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  146 NTSspWDNNGGFRAESESKAQHARQLQFGDVPKPSAGGASSPFPQQPYKSPPLRRH-----------------VRQSEPS 208
Cdd:COG1196    476 EAA--LAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLigveaayeaaleaalaaALQNIVV 553

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  209 TPSSVFPWERDVLWSTPKGR----PTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQLETERMKDVESRLA 284
Cdd:COG1196    554 EDDEVAAAAIEYLKAAKAGRatflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLE 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  285 QANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEElkcqrqnaessrcnaEQRRKDMEREHQRELVEQ 364
Cdd:COG1196    634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE---------------LEELAERLAEEELELEEA 698

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  365 QRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTE 444
Cdd:COG1196    699 LLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207190900  445 -------ALRECESLTVSLGQMKKQEKVLQEEVKRLteelaeaLKLIKEL 487
Cdd:COG1196    779 lgpvnllAIEEYEELEERYDFLSEQREDLEEARETL-------EEAIEEI 821
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
18-448 1.73e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 46.57  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   18 QKVKQLLAQNEKLNKEKQQRQLQLDNSEVALhkqkQKHEEVRVELAAVQRELGGVREAAQAEVRTRERLSHDLQVKTGQV 97
Cdd:PRK02224   213 SELAELDEEIERYEEQREQARETRDEADEVL----EEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERL 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   98 HSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTLF--STPCWNTSSPWDNNGGFRAESESKAQHAR------ 169
Cdd:PRK02224   289 EELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEecRVAAQAHNEEAESLREDADDLEERAEELReeaael 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  170 ----------------QLQFGDVPKPSAGGASSPFPQQPYKSPPLRRHVRQsepstpssvfpwERDVLWSTPKGRPTSLV 233
Cdd:PRK02224   369 eseleeareavedrreEIEELEEEIEELRERFGDAPVDLGNAEDFLEELRE------------ERDELREREAELEATLR 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  234 SSSEVMI---------KSSNCG--MEDALRNE-IDELRVRVSDLQRE-AQLETERmKDVESR------LAQANREISSKE 294
Cdd:PRK02224   437 TARERVEeaealleagKCPECGqpVEGSPHVEtIEEDRERVEELEAElEDLEEEV-EEVEERleraedLVEAEDRIERLE 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  295 QSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQRR---KDMEREHQ------------- 358
Cdd:PRK02224   516 ERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAReevAELNSKLAelkerieslerir 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  359 -----RELVEQQRERQALEKQHQQENNRLNQE-IQQARTLHNTLQAQHDKVCLQ-----KQSLERDLEDVKGKLKNTEAD 427
Cdd:PRK02224   596 tllaaIADAEDEIERLREKREALAELNDERRErLAEKRERKRELEAEFDEARIEearedKERAEEYLEQVEEKLDELREE 675

                          490       500
                   ....*....|....*....|...
gi 1207190900  428 LKESQKREAQTEAKLT--EALRE 448
Cdd:PRK02224   676 RDDLQAEIGAVENELEelEELRE 698
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 669-1010 4.02e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 4.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  669 LQKRLEDLETQRRAETEARTKLKQLsRKHSTQTEQQRAKALELKDSLVKLE----TQLEQEKKESSKLKETLHALQSEAE 744
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEK-RQQLERLRREREKAERYQALLKEKReyegYELLKEKEALERQKEAIERQLASLE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  745 NRKVNDQEEDSQLKKalaEMEQKETIMEE-----------EMMGIKKELQDLQLKLAQEREEREQERLEERKLIRReegl 813
Cdd:TIGR02169  251 EELEKLTEEISELEK---RLEEIEQLLEElnkkikdlgeeEQLRVKEKIGELEAEIASLERSIAEKERELEDAEER---- 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  814 kIAQLQEELD-ILRKSTGLEEKISKDNLPLTYLhlehhqnTDQKADLTENKDLIPSPgVQEFSVNLQNTMVRNEAKTIEL 892
Cdd:TIGR02169  324 -LAKLEAEIDkLLAEIEELEREIEEERKRRDKL-------TEEYAELKEELEDLRAE-LEEVDKEFAETRDELKDYREKL 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  893 imdleAQTKPKTSPSDMNRARAlsteasdLDNSTVLVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLTQAFE 972
Cdd:TIGR02169  395 -----EKLKREINELKRELDRL-------QEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAA 462

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1207190900  973 SQSKhidnLLSELEDKECALQKQAEELQKCQEKICFLE 1010
Cdd:TIGR02169  463 DLSK----YEQELYDLKEEYDRVEKELSKLQRELAEAE 496
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 50-424 1.95e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   50 KQKQKHEEVRVELAAVQRELggvrEAAQAEVRTRERLSHDLQVK----TGQVHSLEGQLESAKKLTQSLTQEIKRLEAEL 125
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKREL----SSLQSELRRIENRLDELSQElsdaSRKIGEIEKEIEQLEQEEEKLKERLEELEEDL 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  126 EKLQKGNGSGESTLfstpcwntsspwDNNGGFRAESESKAqHARQLQFGDvpkPSAGGASSPFPQQPYKSPPLRRHVRQS 205
Cdd:TIGR02169  747 SSLEQEIENVKSEL------------KELEARIEELEEDL-HKLEEALND---LEARLSHSRIPEIQAELSKLEEEVSRI 810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  206 EPSTPSSvfpwERDVLWSTPKGRPTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQ 285
Cdd:TIGR02169  811 EARLREI----EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  286 ANREISskeqsltRTQEQLTRAQtrstQETDRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQ- 364
Cdd:TIGR02169  887 LKKERD-------ELEAQLRELE----RKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEd 955

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190900  365 -QRERQALEKQHQQ---ENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNT 424
Cdd:TIGR02169  956 vQAELQRVEEEIRAlepVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREV 1019
PRK11281 PRK11281
mechanosensitive channel MscK;
1060-1311 2.53e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1060 EKVSEHTVQLPVEASVIQNIDQTNT--SEISDKLQATEHFKQQsvdtsnsstASDAPI-ISDVTEEKSSsvLQDEQLNVV 1136
Cdd:PRK11281    46 DALNKQKLLEAEDKLVQQDLEQTLAllDKIDRQKEETEQLKQQ---------LAQAPAkLRQAQAELEA--LKDDNDEET 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1137 NCQNDSIPehsihdIKELER----VTKELQAAQLELNVM------------KAQN--SELALQGDMIKDKLLNVQQENQE 1198
Cdd:PRK11281   115 RETLSTLS------LRQLESrlaqTLDQLQNAQNDLAEYnsqlvslqtqpeRAQAalYANSQRLQQIRNLLKGGKVGGKA 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1199 LKSTLKHLCEdtgAKQDgALNLANSKNKSLLSSNEGLQSISPLGKEKLVVQHGNSEAEVQSLQEQIqklQDQILDLFEQn 1278
Cdd:PRK11281   189 LRPSQRVLLQ---AEQA-LLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQEAI---NSKRLTLSEK- 260

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1207190900 1279 rtQAEQLElwklsTVEETAGNNSPSIVLKEFEL 1311
Cdd:PRK11281   261 --TVQEAQ-----SQDEAARIQANPLVAQELEI 286
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
632-1018 3.46e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.33  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  632 KLDNTSGKTEKYDSTtlkdlKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRK---HSTQTEQQRAKA 708
Cdd:PRK02224   214 ELAELDEEIERYEEQ-----REQARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREreeLAEEVRDLRERL 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  709 LELKDSLVKLETQLEQEKKESsklkETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLK 788
Cdd:PRK02224   289 EELEEERDDLLAEAGLDDADA----EAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  789 LAQEREEREQERLEERKliRREEglkIAQLQEELDILRKSTGleekiskdNLPLTYLHLEhhqntDQKADLTENKDLIPS 868
Cdd:PRK02224   365 AAELESELEEAREAVED--RREE---IEELEEEIEELRERFG--------DAPVDLGNAE-----DFLEELREERDELRE 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  869 PgVQEFSVNLQNT--------MVRNEAKTIELIMDLEAQTKPKTSPSDMNRARALSTEASDLDNSTVLVLE-VERLRAAR 939
Cdd:PRK02224   427 R-EAELEATLRTArerveeaeALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEErLERAEDLV 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  940 DRESEKAKVSQRK--LEELQKQVTTQTKQLTQAFESQSKHIDNLLSELEDKECALQKQAEELQKCQEKICFLEEKQTRTN 1017
Cdd:PRK02224   506 EAEDRIERLEERRedLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELK 585


                   .
gi 1207190900 1018 D 1018
Cdd:PRK02224   586 E 586
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 682-790 4.65e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.20  E-value: 4.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  682 AETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDsqLKKAL 761
Cdd:cd22656    111 ELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIARKEIKD--LQKEL 188

                           90       100       110
                   ....*....|....*....|....*....|
gi 1207190900  762 AEMEQKETI-MEEEMMGIKKELQDLQLKLA 790
Cdd:cd22656    189 EKLNEEYAAkLKAKIDELKALIADDEAKLA 218
 
Name Accession Description Interval E-value
CENP-F_N pfam10481
Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound ...
 1-270 1.92e-31

Cenp-F N-terminal domain; Mitosin or centromere-associated protein-F (Cenp-F) is found bound across the centromere as one of the proteins of the outer layer of the kinetochore. Most of the kinetochore/centromere functions appear to depend upon binding of the C-terminal par to f the molecule, whereas the N-terminal part, here, may be a cytoplasmic player in controlling the function of microtubules and dynein.


Pssm-ID: 463106 [Multi-domain]  Cd Length: 304  Bit Score: 126.09  E-value: 1.92e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900    1 MSWAGDDWTVGLTGHVLQKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELGGVREAAQAEV 80
Cdd:pfam10481    1 MSWAVEEWKEGLPTKALQKIQELESQLDKLKKERQQKQFQLESLEAALQKQKQKVENEKNEGSALKRENQSLMESCDNLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   81 RTRERLSHDLQVKTGQVHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTL---------FSTPCWNTSSPW 151
Cdd:pfam10481   81 KSRQKISHDLQVKESQVNFLEGQLNSSKKQIEKLEQELKRYKSELERSQQALLAGDVSLqpcstpqksFATPLTPSQRHN 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  152 DNNGGFRAESESKAQHARQLQFGDVPKPSAGGASSPFPQQPYKSPPLRRHvrqsepSTPSSVFPWERD------------ 219
Cdd:pfam10481  161 DSKYEELQEKYNKEVEERKRLEAELKVLQVKKTNQTLPQSTVSHRDIARH------QASSSVFPWQQEktpsrqssdaqe 234

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190900  220 -----------VLW---STPKGRPTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQ 270
Cdd:pfam10481  235 tplkrgftashFLWeheETPSKRSQRSSSNSSLQSNSSSSQLMDQLKAQNQELRSRVSELELRLQ 299
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 249-785 1.21e-18

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 92.69  E-value: 1.21e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHL 328
Cdd:COG1196    270 EELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEA 349

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAEssrcNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQhdkvclqkQ 408
Cdd:COG1196    350 EEELEEAEAELA----EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERL--------E 417

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  409 SLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEAlKLIKELQ 488
Cdd:COG1196    418 RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEA-AARLLLL 496

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  489 AQLAASPPPVAAPNFSSAGDSFSPCVSLHHDRsspfnNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEHIDKfese 568
Cdd:COG1196    497 LEAEADYEGFLEGVKAALLLAGLRGLAGAVAV-----LIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK---- 567

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  569 eksQKRIGVQT-LPSGSLKLTEF-DLDTSVMEQDTGIEDVDTDSFTSDSTRgtmpKSESDISRSLKLDNTSGKTEKYDST 646
Cdd:COG1196    568 ---AAKAGRATfLPLDKIRARAAlAAALARGAIGAAVDLVASDLREADARY----YVLGDTLLGRTLVAARLEAALRRAV 640

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  647 TLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEK 726
Cdd:COG1196    641 TLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEE 720

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  727 KESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDL 785
Cdd:COG1196    721 LEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEAL 779
CENP-F_C_Rb_bdg pfam10490
Rb-binding domain of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, ...
 1632-1677 8.81e-18

Rb-binding domain of kinetochore protein Cenp-F/LEK1; Cenp-F, a centromeric kinetochore, microtubule-binding protein consisting of two 1,600-amino acid-long coils, is essential for the full functioning of the mitotic checkpoint pathway. This domain is at the very C-terminus of the C-terminal coiled-coil, and is one of the key Rb-binding domains.


Pssm-ID: 463111  Cd Length: 47  Bit Score: 78.26  E-value: 8.81e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1207190900 1632 SAAYDETEYEPYGLPEVVMKGFADIPSGPACPYVLRRGLLGTDAMP 1677
Cdd:pfam10490    2 RAEQDDEEFEPEGLPEVVQKGFADIPSGEVSPYILRRTTLQLRCSP 47
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 247-994 9.89e-18

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 90.12  E-value: 9.89e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  247 MEDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVK 326
Cdd:TIGR02168  254 ELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLD 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  327 HLQEELKCQRQNAESSRCNAEQRRKDMEREHQrELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQ 406
Cdd:TIGR02168  334 ELAEELAELEEKLEELKEELESLEAELEELEA-ELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERL 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  407 KQSLERDLEDVKGKLKN-TEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIK 485
Cdd:TIGR02168  413 EDRRERLQQEIEELLKKlEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD 492

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  486 ELQAQLAASPPPVAAPNF----SSAGDSFSPCVS----------------LHHDRSSPF-NNSSQRKRA------PNTGR 538
Cdd:TIGR02168  493 SLERLQENLEGFSEGVKAllknQSGLSGILGVLSelisvdegyeaaieaaLGGRLQAVVvENLNAAKKAiaflkqNELGR 572

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  539 treeeRMKYPSGREPGEGIDSEHIDKFESEE------------KSQKRIGVQTLPSGSLKLTEFDLDTSV---MEQDTGI 603
Cdd:TIGR02168  573 -----VTFLPLDSIKGTEIQGNDREILKNIEgflgvakdlvkfDPKLRKALSYLLGGVLVVDDLDNALELakkLRPGYRI 647

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  604 EDVDTDSFTSD--STRGTMPKSESDISRSLKLDNTSGKTEKYDStTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRR 681
Cdd:TIGR02168  648 VTLDGDLVRPGgvITGGSAKTNSSILERRREIEELEEKIEELEE-KIAELEKALAELRKELEELEEELEQLRKELEELSR 726

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  682 AETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETlhalqseaenrKVNDQEEDSQLKKAL 761
Cdd:TIGR02168  727 QISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEA-----------EAEIEELEAQIEQLK 795

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  762 AEMEQKETIMEEEmmgiKKELQDLQLKLAQEREEREQERLEERKLIRREEGL--KIAQLQEELdilrksTGLEEKISKDN 839
Cdd:TIGR02168  796 EELKALREALDEL----RAELTLLNEEAANLRERLESLERRIAATERRLEDLeeQIEELSEDI------ESLAAEIEELE 865

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  840 LPLTYLHLEHHQNTDQKADLTENKDLIPSpgvQEFSVNLQNTMVRNEAKTIELIMDlEAQTKPKTSPSDMNRARA-LSTE 918
Cdd:TIGR02168  866 ELIEELESELEALLNERASLEEALALLRS---ELEELSEELRELESKRSELRRELE-ELREKLAQLELRLEGLEVrIDNL 941

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  919 ASDLDNSTVLVLE-VERLRAARDRESEKAkvsQRKLEELQKQVttqtKQL-------TQAFESQSKHIDNLLSELEDKEC 990
Cdd:TIGR02168  942 QERLSEEYSLTLEeAEALENKIEDDEEEA---RRRLKRLENKI----KELgpvnlaaIEEYEELKERYDFLTAQKEDLTE 1014


                   ....
gi 1207190900  991 ALQK 994
Cdd:TIGR02168 1015 AKET 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 250-491 1.41e-16

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 86.14  E-value: 1.41e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  250 ALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQ 329
Cdd:COG1196    229 LLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLE 308

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  330 EelkcQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVcLQKQS 409
Cdd:COG1196    309 E----RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-EELEE 383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  410 LERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQA 489
Cdd:COG1196    384 LAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLE 463


                   ..
gi 1207190900  490 QL 491
Cdd:COG1196    464 LL 465
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 255-491 5.52e-15

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 80.75  E-value: 5.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  255 IDELRVRVSDLQREAQL--------ETERMKDVESRLAQ---ANREISSKEQSLTRTQEQLTRAQTRstQETDRAQTAEQ 323
Cdd:COG1196    195 LGELERQLEPLERQAEKaeryrelkEELKELEAELLLLKlreLEAELEELEAELEELEAELEELEAE--LAELEAELEEL 272

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  324 KVKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQ-QRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDk 402
Cdd:COG1196    273 RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRElEERLEELEEELAELEEELEELEEELEELEEELEEAEE- 351

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  403 vclQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALK 482
Cdd:COG1196    352 ---ELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEE 428


                   ....*....
gi 1207190900  483 LIKELQAQL 491
Cdd:COG1196    429 ALAELEEEE 437
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 257-1019 2.10e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.86  E-value: 2.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  257 ELRVRVSDLQREaqLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELkcQR 336
Cdd:TIGR02168  217 ELKAELRELELA--LLVLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL--YA 292

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  337 QNAESSRCNAEQRRKDMEREH---QRELVEQQRERQALEKQHQQEN-NRLNQEIQQARTLHNTLQAQHDKVCLQKQSLER 412
Cdd:TIGR02168  293 LANEISRLEQQKQILRERLANlerQLEELEAQLEELESKLDELAEElAELEEKLEELKEELESLEAELEELEAELEELES 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  413 DLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMK----KQEKVLQE-EVKRLTEELAEALKLIKEL 487
Cdd:TIGR02168  373 RLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQqeieELLKKLEEaELKELQAELEELEEELEEL 452

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  488 QAQLAASPPPVaapnfSSAGDSFSPCVSLHHDRSSPFNNSSQRKRAPNTGRTREEermKYPSG-------REPGEGIDSE 560
Cdd:TIGR02168  453 QEELERLEEAL-----EELREELEEAEQALDAAERELAQLQARLDSLERLQENLE---GFSEGvkallknQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  561 HIDKFESEEKSQKRIGVqTLPSgslkltefDLDTSVME-QDTGIEDVDTDSFTSDSTRGTMPKSESDISRSLKLDNTSGK 639
Cdd:TIGR02168  525 LSELISVDEGYEAAIEA-ALGG--------RLQAVVVEnLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILK 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  640 TEKYDSTTLKDLKKQNAELQDELRD------VKYDLQKRLEDLETQRRAETEARTKLKQLSRKHST--QTEQQRAKALEL 711
Cdd:TIGR02168  596 NIEGFLGVAKDLVKFDPKLRKALSYllggvlVVDDLDNALELAKKLRPGYRIVTLDGDLVRPGGVItgGSAKTNSSILER 675

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  712 KDSLVKLETQLEQEKKESSKLKETLHALQSEAENRkvndQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQ 791
Cdd:TIGR02168  676 RREIEELEEKIEELEEKIAELEKALAELRKELEEL----EEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQ 751

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  792 EREEREQERLEerkliRREEGLKIAQLQEELDilrkstGLEEKISKDNLPLTYLHLEHHQNTDQKADLTENKDLipspgV 871
Cdd:TIGR02168  752 LSKELTELEAE-----IEELEERLEEAEEELA------EAEAEIEELEAQIEQLKEELKALREALDELRAELTL-----L 815

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  872 QEFSVNLQNTMVRNEaktielimdleaqtkpktspsdmNRARALSTEASDLDNSTvlvlevERLRAardrESEKAKVSQR 951
Cdd:TIGR02168  816 NEEAANLRERLESLE-----------------------RRIAATERRLEDLEEQI------EELSE----DIESLAAEIE 862

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190900  952 KLEELQKQVTTQTKQLTQAFESQSKHIDNLLSELEDKECALQKQAEELQKCQEKicfLEEKQTRTNDL 1019
Cdd:TIGR02168  863 ELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRE---LEELREKLAQL 927
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 250-1011 3.85e-13

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 75.10  E-value: 3.85e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  250 ALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSK-EQSLTRTQEQL-----TRAQTRSTQE--TDRAQTA 321
Cdd:TIGR02169  241 AIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLgEEEQLRVKEKIgeleaEIASLERSIAekERELEDA 320

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  322 EQKVKHLQEELKCQRQNAESSRCNAEQRRKDMER------EHQRELVEQQRERQALEKQHQ---QENNRLNQEIQQARTL 392
Cdd:TIGR02169  321 EERLAKLEAEIDKLLAEIEELEREIEEERKRRDKlteeyaELKEELEDLRAELEEVDKEFAetrDELKDYREKLEKLKRE 400

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  393 HNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKR 472
Cdd:TIGR02169  401 INELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDR 480

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  473 LTEELAEALKLIKELQAQLAASPppvaapnfSSAGDSFSPCVSLHHDRSSPFNNSSQrkrapnTGRTREEermkYPSGRE 552
Cdd:TIGR02169  481 VEKELSKLQRELAEAEAQARASE--------ERVRGGRAVEEVLKASIQGVHGTVAQ------LGSVGER----YATAIE 542

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  553 PGEG-------IDSEHIDKFESEEKSQKRIGVQT-LPSGSLKLTEFDLDTSVME------------------------QD 600
Cdd:TIGR02169  543 VAAGnrlnnvvVEDDAVAKEAIELLKRRKAGRATfLPLNKMRDERRDLSILSEDgvigfavdlvefdpkyepafkyvfGD 622

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  601 TGI-EDVDTDSFTSDSTRgtMPKSESDISRSLKLDNTSGKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQ 679
Cdd:TIGR02169  623 TLVvEDIEAARRLMGKYR--MVTLEGELFEKSGAMTGGSRAPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRRI 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  680 RRAETEARTKLKQLSRKHSTqteqqrakalelkdslvkLETQLEQEKKESSKLKETLHALQSEaenrkvndqeedsqlkk 759
Cdd:TIGR02169  701 ENRLDELSQELSDASRKIGE------------------IEKEIEQLEQEEEKLKERLEELEED----------------- 745

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  760 aLAEMEQKETIMEEEMMGIKKELQDLQLKLAqereereQERLEERKLIRREEGLKIAQLQEELDILRKS-TGLEEKISKD 838
Cdd:TIGR02169  746 -LSSLEQEIENVKSELKELEARIEELEEDLH-------KLEEALNDLEARLSHSRIPEIQAELSKLEEEvSRIEARLREI 817

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  839 NLPLTYLHLEHHQNTDQKADLtenkdlipspgvQEFSVNLQNTMVRNEAKTIELIMDLEAQtkpktspsdmnRARALSTE 918
Cdd:TIGR02169  818 EQKLNRLTLEKEYLEKEIQEL------------QEQRIDLKEQIKSIEKEIENLNGKKEEL-----------EEELEELE 874

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  919 ASDLDnstvLVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLT------QAFESQSKHIDNLLSELED---KE 989
Cdd:TIGR02169  875 AALRD----LESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSelkaklEALEEELSEIEDPKGEDEEipeEE 950

                          810       820
                   ....*....|....*....|..
gi 1207190900  990 CALQKQAEELQKCQEKICFLEE 1011
Cdd:TIGR02169  951 LSLEDVQAELQRVEEEIRALEP 972
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 269-506 5.34e-10

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 63.24  E-value: 5.34e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  269 AQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQ 348
Cdd:COG4942     15 AAAQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  349 RRKDMErEHQRELVEQQRERQALEKQHQQE----NNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERdLEDVKGKLKNT 424
Cdd:COG4942     95 LRAELE-AQKEELAELLRALYRLGRQPPLAlllsPEDFLDAVRRLQYLKYLAPARREQAEELRADLAE-LAALRAELEAE 172

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  425 EADLKESQKREAQTEAKLTEALRECESLtvsLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQLAASPPPVAAPNFS 504
Cdd:COG4942    173 RAELEALLAELEEERAALEALKAERQKL---LARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFA 249


                   ..
gi 1207190900  505 SA 506
Cdd:COG4942    250 AL 251
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 660-1000 6.89e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.19  E-value: 6.89e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  660 DELRDVKYDLQKRLEDLETQRRA-------ETEARTKLKQLS----RKHSTQTEQQRAKALELKDSLVKLETQLEQEKKE 728
Cdd:COG1196    189 ERLEDILGELERQLEPLERQAEKaeryrelKEELKELEAELLllklRELEAELEELEAELEELEAELEELEAELAELEAE 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  729 SSKLKETLHALQSEAENRkvndQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEERKLIR 808
Cdd:COG1196    269 LEELRLELEELELELEEA----QAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  809 REEGLKIAQLQEELDILRKSTGLEEKISKdnlpltylhlehhQNTDQKADLTENKDLIpspgvqefsvNLQNTMVRNEAK 888
Cdd:COG1196    345 ELEEAEEELEEAEAELAEAEEALLEAEAE-------------LAEAEEELEELAEELL----------EALRAAAELAAQ 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  889 TIELIMDLEAQTKpktspsdmNRARALSTEASDLDNstvlVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLT 968
Cdd:COG1196    402 LEELEEAEEALLE--------RLERLEEELEELEEA----LAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELL 469

                          330       340       350
                   ....*....|....*....|....*....|..
gi 1207190900  969 QAFESQSKHIDNLLSELEDKECALQKQAEELQ 1000
Cdd:COG1196    470 EEAALLEAALAELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 248-1001 7.03e-10

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 64.31  E-value: 7.03e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRneidELRVRVSDLQREAQLeTERMKDVESRLAQANREIS-----SKEQSLTRTQEQLTRAQTRSTQETDRAQTAE 322
Cdd:TIGR02168  192 EDILN----ELERQLKSLERQAEK-AERYKELKAELRELELALLvlrleELREELEELQEELKEAEEELEELTAELQELE 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  323 QKVkhlqEELKCQRQNAEssrcnaeqrrkdmerehqrelvEQQRERQALEKQHQQENNRLNQEIQQartlhntLQAQHDK 402
Cdd:TIGR02168  267 EKL----EELRLEVSELE----------------------EEIEELQKELYALANEISRLEQQKQI-------LRERLAN 313

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  403 VCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALK 482
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL 393

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  483 LIKELQAQLAASPPPVAAPNfsSAGDSFSPCVSLHHDRSSPFNNSSQRKRAPNTGRTREEERMKYPSGREPGEGID---- 558
Cdd:TIGR02168  394 QIASLNNEIERLEARLERLE--DRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELReele 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  559 --SEHIDKFESEEKS-QKRI---------------GVQTL------PSGSL----KLTEFD--------------LDTSV 596
Cdd:TIGR02168  472 eaEQALDAAERELAQlQARLdslerlqenlegfseGVKALlknqsgLSGILgvlsELISVDegyeaaieaalggrLQAVV 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  597 ME-QDTGIEDVDTDSFTSDSTRGTMPKSESDISRSLKLDNTSGKTEKYDSTTLKDLKKQNAELQDELRD------VKYDL 669
Cdd:TIGR02168  552 VEnLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYllggvlVVDDL 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  670 QKRLEDLETQRRAET------------------EARTKLKQLSRK-----HSTQTEQQRAKALELKDSLVKLETQLEQEK 726
Cdd:TIGR02168  632 DNALELAKKLRPGYRivtldgdlvrpggvitggSAKTNSSILERRreieeLEEKIEELEEKIAELEKALAELRKELEELE 711

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  727 KESSKLKETLHALqseaeNRKVNDQEEDsqlkkaLAEMEQKETIMEEEMMGIKKELQDLQlklAQEREEREQERLEERKL 806
Cdd:TIGR02168  712 EELEQLRKELEEL-----SRQISALRKD------LARLEAEVEQLEERIAQLSKELTELE---AEIEELEERLEEAEEEL 777

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  807 IRREEglKIAQLQEELDILRKSTG-LEEKISKDNLPLTYLHLEHHQNTDQKADLTENKDLIpspgvQEFSVNLQNTMVRN 885
Cdd:TIGR02168  778 AEAEA--EIEELEAQIEQLKEELKaLREALDELRAELTLLNEEAANLRERLESLERRIAAT-----ERRLEDLEEQIEEL 850

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  886 EAKTIELIMDLEAQTKPKTSPSD-----------MNRARALSTEASDLDNSTVLVLEVERLRAARDRESEKAKVSQ--RK 952
Cdd:TIGR02168  851 SEDIESLAAEIEELEELIEELESeleallnerasLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQleLR 930

                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 1207190900  953 LEELQKQVTTQTKQLTQAFESQSKHIDNLLSELEDKECALQKQAEELQK 1001
Cdd:TIGR02168  931 LEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLEN 979
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
249-486 8.37e-10

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 64.17  E-value: 8.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELrvrvSDLQREAqLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAqtrstqetdRAQTAEQKVKHL 328
Cdd:COG4913    228 DALVEHFDDL----ERAHEAL-EDAREQIELLEPIRELAERYAAARERLAELEYLRAAL---------RLWFAQRRLELL 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAESsrcnAEQRRkdmeREHQRELVEQQRERQALEKQHQQEN----NRLNQEIQQARTLHNTLQAQHDKvc 404
Cdd:COG4913    294 EAELEELRAELAR----LEAEL----ERLEARLDALREELDELEAQIRGNGgdrlEQLEREIERLERELEERERRRAR-- 363

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  405 lqkqsLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECE----SLTVSLGQMKKQEKVLQEEVKRLT------ 474
Cdd:COG4913    364 -----LEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEealaEAEAALRDLRRELRELEAEIASLErrksni 438

                          250       260
                   ....*....|....*....|
gi 1207190900  475 --------EELAEALKLIKE 486
Cdd:COG4913    439 parllalrDALAEALGLDEA 458
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 272-491 1.92e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.65  E-value: 1.92e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  272 ETE-RMKDVESRLAQANREISSKEQSLTRTQEQLTRAQtrstqetdRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQRR 350
Cdd:COG1196    176 EAErKLEATEENLERLEDILGELERQLEPLERQAEKAE--------RYRELKEELKELEAELLLLKLRELEAELEELEAE 247

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  351 KDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKE 430
Cdd:COG1196    248 LEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190900  431 SQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:COG1196    328 LEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEEL 388
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 248-972 1.95e-09

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 62.68  E-value: 1.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLT---RTQEQLTRAQTRSTQETDRAQTAEQK 324
Cdd:pfam02463  295 EEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKeleIKREAEEEEEEELEKLQEKLEQLEEE 374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  325 VKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLN--QEIQQARTLHNTLQAQHDK 402
Cdd:pfam02463  375 LLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEeeEESIELKQGKLTEEKEELE 454

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  403 V--------CLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESL-------------TVSLGQMKK 461
Cdd:pfam02463  455 KqelkllkdELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLlalikdgvggriiSAHGRLGDL 534

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  462 QEKVLQEEVKRLTEELAEALKLIKELQAQLAASPPPVAAPNF--------SSAGDSFSPCVSLHHDRSSPFNNSSQRKRA 533
Cdd:pfam02463  535 GVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGarklrlliPKLKLPLKSIAVLEIDPILNLAQLDKATLE 614

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  534 PNTGRTREEERMKYPSGREPGEGIDSEHIDKFESEEKSQKRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEDVDTDSFTS 613
Cdd:pfam02463  615 ADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEI 694

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  614 DSTRGTMPKSESDISRSLKLDNTSgKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQL 693
Cdd:pfam02463  695 LRRQLEIKKKEQREKEELKKLKLE-AEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKE 773

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  694 SRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEE 773
Cdd:pfam02463  774 KELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAE 853

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  774 EMmgiKKELQDLQLKLAQEREEREQERLEERKLIRREEGLKIAQLQEELDILRKSTGLEEKISKDNLPLTYLHLEHHQNT 853
Cdd:pfam02463  854 EE---LERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEIL 930

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  854 DQKADLTENKDLIPSPGVQEFSVNLQNTMVRNeaktielimDLEAQTKPKTSPSDMNRARAlsteasdldnstvlvlEVE 933
Cdd:pfam02463  931 LKYEEEPEELLLEEADEKEKEENNKEEEEERN---------KRLLLAKEELGKVNLMAIEE----------------FEE 985

                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 1207190900  934 RLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLTQAFE 972
Cdd:pfam02463  986 KEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEFLE 1024
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
253-765 2.73e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.00  E-value: 2.73e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  253 NEIDELRVRVSDLQRE---AQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQ 329
Cdd:PRK03918   207 REINEISSELPELREElekLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKELK 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  330 E----------------ELKCQRQNAESSRCNAEQRRKDMEREHQrELVEQQRERQALEKQHQQENNRLNQEIQQARTLH 393
Cdd:PRK03918   287 ElkekaeeyiklsefyeEYLDELREIEKRLSRLEEEINGIEERIK-ELEEKEERLEELKKKLKELEKRLEELEERHELYE 365

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  394 NTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKV-------L 466
Cdd:PRK03918   366 EAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgreL 445

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  467 QEE-----VKRLTEELAEALKLIKELQAQLAASPPpvaapnfssagdsfspcvslhhdrsspfnnssqRKRAPNTGRTRE 541
Cdd:PRK03918   446 TEEhrkelLEEYTAELKRIEKELKEIEEKERKLRK---------------------------------ELRELEKVLKKE 492

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  542 EERMKYPSGREPGEGIDSEhIDKFESEEKSQKRIGVQTLPSGSLKLTEfdlDTSVMEQD-TGIEDVDTDSFTSDSTRGTM 620
Cdd:PRK03918   493 SELIKLKELAEQLKELEEK-LKKYNLEELEKKAEEYEKLKEKLIKLKG---EIKSLKKElEKLEELKKKLAELEKKLDEL 568

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  621 PKSESDISRSLK---------LDNTSGKTEKY--DSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTK 689
Cdd:PRK03918   569 EEELAELLKELEelgfesveeLEERLKELEPFynEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKE 648

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190900  690 LKQLSRKHSTQT-EQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKvNDQEEDSQLKKALAEME 765
Cdd:PRK03918   649 LEELEKKYSEEEyEELREEYLELSRELAGLRAELEELEKRREEIKKTLEKLKEELEERE-KAKKELEKLEKALERVE 724
46 PHA02562
endonuclease subunit; Provisional
 628-790 3.53e-09

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 61.57  E-value: 3.53e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  628 SRSLKLDNTSGKTEKYDS--TTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHS------- 698
Cdd:PHA02562   207 QRKKNGENIARKQNKYDElvEEAKTIKAEIEELTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggv 286

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  699 ----TQT-EQQRAKALELKDSLVKLETQLEQEKKESSKLKE----------TLHALQSEAENRKVNDQEEDSQLKKALAE 763
Cdd:PHA02562   287 cptcTQQiSEGPDRITKIKDKLKELQHSLEKLDTAIDELEEimdefneqskKLLELKNKISTNKQSLITLVDKAKKVKAA 366

                          170       180       190
                   ....*....|....*....|....*....|
gi 1207190900  764 MEQKE---TIMEEEMMGIKKELQDLQLKLA 790
Cdd:PHA02562   367 IEELQaefVDNAEELAKLQDELDKIVKTKS 396
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 648-833 4.40e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 61.49  E-value: 4.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQ--NA----ELQDELRDVKYDLQ-KRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLET 720
Cdd:COG1196    202 LEPLERQaeKAeryrELKEELKELEAELLlLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELEL 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  721 QLEQEKKESSKLKETLHALQS----------EAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLA 790
Cdd:COG1196    282 ELEEAQAEEYELLAELARLEQdiarleerrrELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA 361

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1207190900  791 QEREEREQERLEERKLIRREEGLKIAQLQEELDILRKSTGLEE 833
Cdd:COG1196    362 EAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEE 404
PTZ00121 PTZ00121
MAEBL; Provisional
 261-891 5.11e-09

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 61.70  E-value: 5.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  261 RVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKV--KHLQEELKcqrQN 338
Cdd:PTZ00121  1247 EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAeeAKKADEAK---KK 1323

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  339 AESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTlHNTLQAQHDKVCLQKQSLERDLEDVK 418
Cdd:PTZ00121  1324 AEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEA-KKKADAAKKKAEEKKKADEAKKKAEE 1402

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  419 GKLKNTEADLKESQKREAQTEAKLTEALRECESLtvslgQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQLAASPPPV 498
Cdd:PTZ00121  1403 DKKKADELKKAAAAKKKADEAKKKAEEKKKADEA-----KKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKK 1477

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  499 AAPNFSSAGDSFspcvslhhdrsspfNNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEHIDKFESEEKS------- 571
Cdd:PTZ00121  1478 KAEEAKKADEAK--------------KKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKAdeakkae 1543

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  572 QKRIGVQTLPSGSLKLTEfdlDTSVMEQDTGIEDVDTDSFTSDSTRGTMPKSESDISRSLKLDNTSGKTEKYDSTTLKDL 651
Cdd:PTZ00121  1544 EKKKADELKKAEELKKAE---EKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKI 1620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  652 KKQNAELQDELRDVKYDLQKRLED----LETQRRAETEARTKLKQLSRKhstqTEQQRAKALELKDSLVKLETQLEQEKK 727
Cdd:PTZ00121  1621 KAEELKKAEEEKKKVEQLKKKEAEekkkAEELKKAEEENKIKAAEEAKK----AEEDKKKAEEAKKAEEDEKKAAEALKK 1696

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  728 ESSKLKETLHALQSEAENRK----VNDQEEDSQLKKALAEMEQKETIMEEEMM----GIKKELQDLQLKLAQEREEREQE 799
Cdd:PTZ00121  1697 EAEEAKKAEELKKKEAEEKKkaeeLKKAEEENKIKAEEAKKEAEEDKKKAEEAkkdeEEKKKIAHLKKEEEKKAEEIRKE 1776

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  800 RLEERK--LIRREEGLKIAQLQEELDILRKSTGLEEKISKDNLPLtylhlehhqNTDQKADLTENKDLIPSpgvqefsvn 877
Cdd:PTZ00121  1777 KEAVIEeeLDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVI---------NDSKEMEDSAIKEVADS--------- 1838

                          650
                   ....*....|....
gi 1207190900  878 lqNTMVRNEAKTIE 891
Cdd:PTZ00121  1839 --KNMQLEEADAFE 1850
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 249-487 6.77e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 61.23  E-value: 6.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQreaqletERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHL 328
Cdd:TIGR02168  806 DELRAELTLLNEEAANLR-------ERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEAL 878

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAESSRCNAEQRRKDMeREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHdkvclqkq 408
Cdd:TIGR02168  879 LNERASLEEALALLRSELEELSEEL-RELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEY-------- 949

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  409 slERDLEDVKGKLKNTEADLKESQKREAQTEAKLTE-------ALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEAL 481
Cdd:TIGR02168  950 --SLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaAIEEYEELKERYDFLTAQKEDLTEAKETLEEAIEEID 1027


                   ....*.
gi 1207190900  482 KLIKEL 487
Cdd:TIGR02168 1028 REARER 1033
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 248-491 1.08e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 60.34  E-value: 1.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKH 327
Cdd:COG1196    325 LAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEE 404

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  328 LQEELkcQRQNAESSRCNAEQRRKDMEREHQRELVEQQR----ERQALEKQHQQENNRLNQEIQQARTLHNTLQAQhdkv 403
Cdd:COG1196    405 LEEAE--EALLERLERLEEELEELEEALAELEEEEEEEEealeEAAEEEAELEEEEEALLELLAELLEEAALLEAA---- 478

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  404 cLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEE-----VKRLTEELA 478
Cdd:COG1196    479 -LAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAAlaaalQNIVVEDDE 557

                          250
                   ....*....|...
gi 1207190900  479 EALKLIKELQAQL 491
Cdd:COG1196    558 VAAAAIEYLKAAK 570
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 19-822 2.42e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 2.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   19 KVKQLLAQNEK----LNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRElggvREAAQAEVRTRERlshDLQVKT 94
Cdd:TIGR02168  201 QLKSLERQAEKaeryKELKAELRELELALLVLRLEELREELEELQEELKEAEEE----LEELTAELQELEE---KLEELR 273

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   95 GQVHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTLFSTpcwntsspwdnnGGFRAESESKAQHARQL--- 171
Cdd:TIGR02168  274 LEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEEL------------EAQLEELESKLDELAEElae 341

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  172 ---QFGDVpKPSAGGASSPFPQQPYKSPPLRRHVRqsepstpssvfpwERDVLWSTPKGRPTSLVSSsevmikssncgmE 248
Cdd:TIGR02168  342 leeKLEEL-KEELESLEAELEELEAELEELESRLE-------------ELEEQLETLRSKVAQLELQ------------I 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQRE-----AQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQ 323
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRrerlqQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQ 475

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  324 KVKHLQEELkcqrqNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKV 403
Cdd:TIGR02168  476 ALDAAEREL-----AQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAV 550

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  404 CL-----QKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEaLRECESLTVSLGQMKKQ-EKVLQEEVKRL--TE 475
Cdd:TIGR02168  551 VVenlnaAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKN-IEGFLGVAKDLVKFDPKlRKALSYLLGGVlvVD 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  476 ELAEALKLIKELQAQlaaspppvaAPNFSSAGDSFSPCVSLhhdrsspfNNSSQRKRAPNTGRTREEERMkypsgrepge 555
Cdd:TIGR02168  630 DLDNALELAKKLRPG---------YRIVTLDGDLVRPGGVI--------TGGSAKTNSSILERRREIEEL---------- 682

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  556 gidSEHIDKFES--EEKSQKRIGVQTLPSgSLKLTEFDLDTSVMEQDTGIEDVDTDSFTSDStrgtmpKSESDISRSLKL 633
Cdd:TIGR02168  683 ---EEKIEELEEkiAELEKALAELRKELE-ELEEELEQLRKELEELSRQISALRKDLARLEA------EVEQLEERIAQL 752

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  634 DNTSGKTEKYDSTTLKDLKKQNAELQ---DELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEqqraKALE 710
Cdd:TIGR02168  753 SKELTELEAEIEELEERLEEAEEELAeaeAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRE----RLES 828

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  711 LKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIM---EEEMMGIKKELQDLQL 787
Cdd:TIGR02168  829 LERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALallRSELEELSEELRELES 908

                          810       820       830
                   ....*....|....*....|....*....|....*..
gi 1207190900  788 KLAQEREEREQERLEERKLIRREEGLK--IAQLQEEL 822
Cdd:TIGR02168  909 KRSELRRELEELREKLAQLELRLEGLEvrIDNLQERL 945
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
250-785 3.11e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 3.11e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  250 ALRNEIDELRVRVSD-LQREAQLEtERMKDVESRLAQANREISSKEQSLTRTQEQLtraqtrstqetdraqtaeQKVKHL 328
Cdd:PRK03918   169 EVIKEIKRRIERLEKfIKRTENIE-ELIKEKEKELEEVLREINEISSELPELREEL------------------EKLEKE 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAESSRCNAEQRRKDMER--EHQRELVEQQRERQALEKQHQQENNRLNqEIQQARTLHNTLQAQHDKVCLQ 406
Cdd:PRK03918   230 VKELEELKEEIEELEKELESLEGSKRKleEKIRELEERIEELKKEIEELEEKVKELK-ELKEKAEEYIKLSEFYEEYLDE 308

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  407 KQSLERDLEDVKGKLKNTEADLKESQKREAQteakltealrecesltvsLGQMKKQEKVLQEEVKRLtEELAEALKLIKE 486
Cdd:PRK03918   309 LREIEKRLSRLEEEINGIEERIKELEEKEER------------------LEELKKKLKELEKRLEEL-EERHELYEEAKA 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  487 LQAQLaaspppvaapnfssagdsfspcvslhhdrsspfnnssQRKRAPNTGRTREEERMKYPSGREPGEGIDSEhIDKFE 566
Cdd:PRK03918   370 KKEEL-------------------------------------ERLKKRLTGLTPEKLEKELEELEKAKEEIEEE-ISKIT 411

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  567 SEEksqkrigvqtlpsGSLKLTEFDLDTSVMEQDtgiedvdtdsftsdSTRGTMPKSesdiSRSLKLDNTSGKTEKYdST 646
Cdd:PRK03918   412 ARI-------------GELKKEIKELKKAIEELK--------------KAKGKCPVC----GRELTEEHRKELLEEY-TA 459

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  647 TLKDLKKQNAELQDELRDvkydLQKRLEDLETQRRAETEartklkqLSRKHSTQTEqqrAKALELKDSLVKLEtQLEQEK 726
Cdd:PRK03918   460 ELKRIEKELKEIEEKERK----LRKELRELEKVLKKESE-------LIKLKELAEQ---LKELEEKLKKYNLE-ELEKKA 524

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  727 KESSKLKETLHALQSEAENRKvNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDL 785
Cdd:PRK03918   525 EEYEKLKEKLIKLKGEIKSLK-KELEKLEELKKKLAELEKKLDELEEELAELLKELEEL 582
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 248-436 8.58e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 56.31  E-value: 8.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTR----AQTRSTQETDRAQTAEQ 323
Cdd:COG4942     50 EKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAEllraLYRLGRQPPLALLLSPE 129

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  324 KVKHLQEELKCQRQNAESSRCNAEQRRKDMER--EHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHD 401
Cdd:COG4942    130 DFLDAVRRLQYLKYLAPARREQAEELRADLAElaALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELA 209

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1207190900  402 KVCLQKQSLERDLEDVKGKLKNTEADLKESQKREA 436
Cdd:COG4942    210 ELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 17-481 1.45e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 56.48  E-value: 1.45e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   17 LQKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELGGVREAAQAEVRTRERLSHDLQVKTGQ 96
Cdd:COG1196    231 LLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   97 VHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQkgngsgestlfstpcwntsspwdnnggfrAESESKAQHARQLQfgdv 176
Cdd:COG1196    311 RRELEERLEELEEELAELEEELEELEEELEELE-----------------------------EELEEAEEELEEAE---- 357

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  177 pkpsaggasspfpqqpykspplrrhvrqsepstpssvfpwerdvlwstpkgrptslvsssevmikssncgmedALRNEID 256
Cdd:COG1196    358 -------------------------------------------------------------------------AELAEAE 364

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  257 ELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQR 336
Cdd:COG1196    365 EALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEAL 444

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  337 QNAEssrcnAEQRRKDMEREHQRELVEQQRERQALEKQHQQEnnrLNQEIQQARTLHNTLQAQHDkvclqkqSLERDLED 416
Cdd:COG1196    445 EEAA-----EEEAELEEEEEALLELLAELLEEAALLEAALAE---LLEELAEAAARLLLLLEAEA-------DYEGFLEG 509

                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190900  417 VKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEAL 481
Cdd:COG1196    510 VKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRA 574
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 648-1108 1.64e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.64e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKYDLQKRLEDLETQ----RRAETEARTKLKQLSRKHSTQTEQQRakalELKDSLVKLETQLE 723
Cdd:pfam15921  319 LSDLESTVSQLRSELREAKRMYEDKIEELEKQlvlaNSELTEARTERDQFSQESGNLDDQLQ----KLLADLHKREKELS 394

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  724 QEKKESSKLKE-------TLHALQSEAENRKVNDQEEDSQLKKALAEMEQKetiMEEEMMGIKKELQDLQlKLAQEREER 796
Cdd:pfam15921  395 LEKEQNKRLWDrdtgnsiTIDHLRRELDDRNMEVQRLEALLKAMKSECQGQ---MERQMAAIQGKNESLE-KVSSLTAQL 470

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  797 EQERLEERKLIRREEGLKIAQLQEELDILRKSTGLEEK---ISKDNLPLTYL------------HL----EHHQNTDQKA 857
Cdd:pfam15921  471 ESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKeraIEATNAEITKLrsrvdlklqelqHLknegDHLRNVQTEC 550

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  858 DLTENKDLIPSPGVQEFSVNLQNTM--VRNEAKTIELIMDLEAQTKPKTSPSDMN-------------RARALSTEASDL 922
Cdd:pfam15921  551 EALKLQMAEKDKVIEILRQQIENMTqlVGQHGRTAGAMQVEKAQLEKEINDRRLElqefkilkdkkdaKIRELEARVSDL 630

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  923 DNSTVLVLEV--ERLRAARDRE--------------------SEKAKVSQRKLEELQKQVTTQTKQLTQAFESQSKHID- 979
Cdd:pfam15921  631 ELEKVKLVNAgsERLRAVKDIKqerdqllnevktsrnelnslSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEq 710

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  980 --NLLSELEDKECALQKQAEELQK-----------CQEKICFLEEKQTRTN-DLSAPPELSTEISRELSCDSVFSNTSIS 1045
Cdd:pfam15921  711 trNTLKSMEGSDGHAMKVAMGMQKqitakrgqidaLQSKIQFLEEAMTNANkEKHFLKEEKNKLSQELSTVATEKNKMAG 790

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900 1046 DHEMFSDDTPPvLKEKVSEHTVQL---PVEASVIQNIDQTNTSE-ISDKLQATEHFK--QQSVDTSNSS 1108
Cdd:pfam15921  791 ELEVLRSQERR-LKEKVANMEVALdkaSLQFAECQDIIQRQEQEsVRLKLQHTLDVKelQGPGYTSNSS 858
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
248-390 5.53e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.92  E-value: 5.53e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQRE-AQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVK 326
Cdd:COG4913    311 LERLEARLDALREELDELEAQiRGNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAA 390

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190900  327 HLQEELKCQRQNAESSRCNAEQRRKDMEREHQrelvEQQRERQALEKQHqqenNRLNQEIQQAR 390
Cdd:COG4913    391 ALLEALEEELEALEEALAEAEAALRDLRRELR----ELEAEIASLERRK----SNIPARLLALR 446
PTZ00121 PTZ00121
MAEBL; Provisional
 248-811 8.96e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 54.38  E-value: 8.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDE--LRVRVSDLQREAQ----LETERMKDVESRLAQANR-EISSKEQSLTRTQEQLTRAQTRSTQETDRAQT 320
Cdd:PTZ00121  1173 EDAKKAEAARkaEEVRKAEELRKAEdarkAEAARKAEEERKAEEARKaEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE 1252

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  321 AEQKVKHLQEELKCQRQNAessrCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQH 400
Cdd:PTZ00121  1253 EIRKFEEARMAHFARRQAA----IKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAK 1328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  401 DKVCLQKQSLE---RDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLtvslgQMKKQEKVLQEEVKRLTEEL 477
Cdd:PTZ00121  1329 KKADAAKKKAEeakKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA-----KKKAEEKKKADEAKKKAEED 1403

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  478 AEALKLIKELQAQLAASPPPVAAPNFSSAGDSFSPCVSLHHDRSSPFNNSSQRKRAPNTGRTREEERMKYPSGREPGEGI 557
Cdd:PTZ00121  1404 KKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAK 1483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  558 DSEHIDKfESEEKSQKRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEdvDTDSFTSDSTRGTMPKSESDISRSL----KL 633
Cdd:PTZ00121  1484 KADEAKK-KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKK--AEEAKKADEAKKAEEKKKADELKKAeelkKA 1560

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  634 DNTSGKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKD 713
Cdd:PTZ00121  1561 EEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKK 1640

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  714 SLVKLETQLEQEKK--ESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQ 791
Cdd:PTZ00121  1641 KEAEEKKKAEELKKaeEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEE 1720

                          570       580
                   ....*....|....*....|
gi 1207190900  792 EREEREQERLEERKLIRREE 811
Cdd:PTZ00121  1721 LKKAEEENKIKAEEAKKEAE 1740
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
300-491 9.03e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 54.15  E-value: 9.03e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  300 TQEQLTRaqtrstqeTDRAQTAEQKVKHLQEELKCQRQNAESSR----CNAEQRRKDMEREH---QRELVEQQRERQALE 372
Cdd:COG4913    566 SPEELRR--------HPRAITRAGQVKGNGTRHEKDDRRRIRSRyvlgFDNRAKLAALEAELaelEEELAEAEERLEALE 637

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  373 KQHQQennrlnqeIQQARTLHNTLQaQHDKVCLQKQSLER---DLEDVKGKLKNTEADLKESQKREAQTEAKLTEALREC 449
Cdd:COG4913    638 AELDA--------LQERREALQRLA-EYSWDEIDVASAEReiaELEAELERLDASSDDLAALEEQLEELEAELEELEEEL 708

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1207190900  450 ESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:COG4913    709 DELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRAL 750
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 254-448 1.02e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 52.91  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  254 EIDELRVRVSDLQREAQletermkDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELK 333
Cdd:COG3883     17 QIQAKQKELSELQAELE-------AAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELG 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  334 CQ-RQNAESSRCNAE--------------QRRKDMER--EHQRELVEQQRERQALEKQHQQEnnrLNQEIQQARTLHNTL 396
Cdd:COG3883     90 ERaRALYRSGGSVSYldvllgsesfsdflDRLSALSKiaDADADLLEELKADKAELEAKKAE---LEAKLAELEALKAEL 166

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207190900  397 QAqhdkvclQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRE 448
Cdd:COG3883    167 EA-------AKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAA 211
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 266-490 1.05e-06

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 53.59  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  266 QREAQLETERMKDVEsRLA---QANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQRQNAESS 342
Cdd:pfam17380  367 QEEIAMEISRMRELE-RLQmerQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERA 445

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  343 RCNAEQRRKDMEREHQRELVEQQ---RERQALEKQHQQENNRLNQEiQQARTLHNTLQAQHDKVCLQKQS---LERDLED 416
Cdd:pfam17380  446 REMERVRLEEQERQQQVERLRQQeeeRKRKKLELEKEKRDRKRAEE-QRRKILEKELEERKQAMIEEERKrklLEKEMEE 524

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190900  417 vkgklkNTEADLKESQKREAQTEAKLTEALRECEsltvslgQMKKQEKVLQEEVKRL--TEELAEALKLIKELQAQ 490
Cdd:pfam17380  525 ------RQKAIYEEERRREAEEERRKQQEMEERR-------RIQEQMRKATEERSRLeaMEREREMMRQIVESEKA 587
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
249-448 1.11e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.77  E-value: 1.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANR--EISSKEQSLTRTQEQLTRAQtrstQETDRAQTAEQKVK 326
Cdd:COG4913    613 AALEAELAELEEELAEAEERLEALEAELDALQERREALQRlaEYSWDEIDVASAEREIAELE----AELERLDASSDDLA 688

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  327 HLQEELKcqrqnaessrcNAEQRRKdmerEHQRELVEQQRERQALEKQHQQennrLNQEIQQARTLHNT---LQAQHDKV 403
Cdd:COG4913    689 ALEEQLE-----------ELEAELE----ELEEELDELKGEIGRLEKELEQ----AEEELDELQDRLEAaedLARLELRA 749

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 1207190900  404 CLQKQSLERDLEDVKGKL-KNTEADLKESQKREAQTEAKLTEALRE 448
Cdd:COG4913    750 LLEERFAAALGDAVERELrENLEERIDALRARLNRAEEELERAMRA 795
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 256-491 1.20e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 53.69  E-value: 1.20e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  256 DELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQtaeqkvkhlQEELKCQ 335
Cdd:pfam12128  600 EELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQ---------SEKDKKN 670

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  336 RQNAESSRcNAEQRRKDMEREHQRELVEQQrerQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVclqKQSLERDLE 415
Cdd:pfam12128  671 KALAERKD-SANERLNSLEAQLKQLDKKHQ---AWLEEQKEQKREARTEKQAYWQVVEGALDAQLALL---KAAIAARRS 743

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  416 DVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQE-KVLQEEV----------KRLTEELAEALKLI 484
Cdd:pfam12128  744 GAKAELKALETWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRqEVLRYFDwyqetwlqrrPRLATQLSNIERAI 823


                   ....*..
gi 1207190900  485 KELQAQL 491
Cdd:pfam12128  824 SELQQQL 830
PTZ00121 PTZ00121
MAEBL; Provisional
 266-1015 1.23e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 53.61  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  266 QREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQ-TRSTQETDRAQTA----------EQKVKHLQEELKC 334
Cdd:PTZ00121  1083 AKEDNRADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEdARKAEEARKAEDArkaeearkaeDAKRVEIARKAED 1162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  335 QRQNAESSRCN----AEQRRKDMEREHQRELVEQQRERQA-----LEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCL 405
Cdd:PTZ00121  1163 ARKAEEARKAEdakkAEAARKAEEVRKAEELRKAEDARKAeaarkAEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEA 1242

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  406 QKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIK 485
Cdd:PTZ00121  1243 KKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKK 1322

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  486 ELQAQLAASPPPVAAPNFSSAGDSfspcVSLHHDRSSPFNNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEHIDKF 565
Cdd:PTZ00121  1323 KAEEAKKKADAAKKKAEEAKKAAE----AAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKK 1398

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  566 ESEEKSQKRIGVQTLPSGSLKLTEfdldtsvmeqdtgiedvdtdsftsdstrgtMPKSESDISRSLKLDNTSGKTEKYDS 645
Cdd:PTZ00121  1399 KAEEDKKKADELKKAAAAKKKADE------------------------------AKKKAEEKKKADEAKKKAEEAKKADE 1448

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  646 TTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAEtEARTKLKQLSRK--HSTQTEQQRAKALELKDSlvkletqle 723
Cdd:PTZ00121  1449 AKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKAD-EAKKKAEEAKKKadEAKKAAEAKKKADEAKKA--------- 1518

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  724 QEKKESSKLKETLHALQSEaENRKVNDQEEDSQLKKAlAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREE-REQERLE 802
Cdd:PTZ00121  1519 EEAKKADEAKKAEEAKKAD-EAKKAEEKKKADELKKA-EELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKaEEARIEE 1596

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  803 ERKLIRREEGLKIAQLQEELDILRKSTGL--EEKISKDNLPLTYLHLEHHQNTDQKADLTEnkdlipspgvqefsvnlQN 880
Cdd:PTZ00121  1597 VMKLYEEEKKMKAEEAKKAEEAKIKAEELkkAEEEKKKVEQLKKKEAEEKKKAEELKKAEE-----------------EN 1659

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  881 TMVRNEAKTIELIMDLEAQTKPKTSPSDMNRARALSTEASDLDnstvlvlEVERLRAARDRESEKA-------KVSQRKL 953
Cdd:PTZ00121  1660 KIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAK-------KAEELKKKEAEEKKKAeelkkaeEENKIKA 1732

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  954 EELQKQVTTQTKQLTQAF--ESQSKHIDNLLSELEDKECALQKQA-----EELQKCQEKICFLEEKQTR 1015
Cdd:PTZ00121  1733 EEAKKEAEEDKKKAEEAKkdEEEKKKIAHLKKEEEKKAEEIRKEKeavieEELDEEDEKRRMEVDKKIK 1801
PRK11281 PRK11281
mechanosensitive channel MscK;
252-445 1.56e-06

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 53.38  E-value: 1.56e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  252 RNEIDELRVRVSDLQREaQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRStqetDRAQTA-EQKVKHLQE 330
Cdd:PRK11281   100 QAELEALKDDNDEETRE-TLSTLSLRQLESRLAQTLDQLQNAQNDLAEYNSQLVSLQTQP----ERAQAAlYANSQRLQQ 174

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  331 ---ELKCQRQNAESSRcnAEQRrkdmerehqrelVEQQRERQALEKQHQQenNRlnQEIQQARTLHNTLQAQHDKVCLQK 407
Cdd:PRK11281   175 irnLLKGGKVGGKALR--PSQR------------VLLQAEQALLNAQNDL--QR--KSLEGNTQLQDLLQKQRDYLTARI 236

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 1207190900  408 QSLERDLEDVKGKLknteadlkeSQKREAQTEAKLTEA 445
Cdd:PRK11281   237 QRLEHQLQLLQEAI---------NSKRLTLSEKTVQEA 265
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
319-491 1.60e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.38  E-value: 1.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  319 QTAEQKVKHLQEELKCQRQNAESsrcnAEQRRKDMEREhQRELVEQQRERQALE---------KQHQQENNRLNQEIQQA 389
Cdd:COG4913    606 FDNRAKLAALEAELAELEEELAE----AEERLEALEAE-LDALQERREALQRLAeyswdeidvASAEREIAELEAELERL 680

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  390 RTLHN---TLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVL 466
Cdd:COG4913    681 DASSDdlaALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEERFAAALG 760

                          170       180
                   ....*....|....*....|....*
gi 1207190900  467 QEEVKRLTEELAEALKLIKELQAQL 491
Cdd:COG4913    761 DAVERELRENLEERIDALRARLNRA 785
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
319-767 2.01e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 52.46  E-value: 2.01e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  319 QTAEQKVKHLQEELKcQRQNAESSRCNAEQRRKDMEREhqRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQA 398
Cdd:COG4717     81 KEAEEKEEEYAELQE-ELEELEEELEELEAELEELREE--LEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEE 157

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  399 QHDkvclqkqsLERDLEDVKGKLKNTEADLKESQKR-EAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEEL 477
Cdd:COG4717    158 LRE--------LEEELEELEAELAELQEELEELLEQlSLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEEL 229

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  478 aEALKLIKELQAQLAASPPPVAAPNFSSAGDSFSPCVSLHHDRSSPFNNSSQRKRAPNTGRTREEERMKYPSGREPGEGI 557
Cdd:COG4717    230 -EQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKEAEELQ 308

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  558 DSEHIDKFESEEKSQ--KRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEDVdtdsftsdstrgtmpksESDISRSLKLDN 635
Cdd:COG4717    309 ALPALEELEEEELEEllAALGLPPDLSPEELLELLDRIEELQELLREAEEL-----------------EEELQLEELEQE 371

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  636 TSGKTEKYDSTTLKDLkKQNAELQDELRdvkyDLQKRLEDLETQRRAETEARtklkqLSRKHSTQTEQQRAKALELKDSL 715
Cdd:COG4717    372 IAALLAEAGVEDEEEL-RAALEQAEEYQ----ELKEELEELEEQLEELLGEL-----EELLEALDEEELEEELEELEEEL 441

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207190900  716 VKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEdsQLKKALAEMEQK 767
Cdd:COG4717    442 EELEEELEELREELAELEAELEQLEEDGELAELLQELE--ELKAELRELAEE 491
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 250-487 2.07e-06

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 52.76  E-value: 2.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  250 ALRNEIDELRVRVSDLQREAQLETERMKDVESRLA-----QANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQK 324
Cdd:TIGR02169  755 NVKSELKELEARIEELEEDLHKLEEALNDLEARLShsripEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKE 834

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  325 VKHLQEELKcQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQH---QQENNRLNQEIQQARTLHNTLQAQHD 401
Cdd:TIGR02169  835 IQELQEQRI-DLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLgdlKKERDELEAQLRELERKIEELEAQIE 913

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  402 KVCLQKQSLERDLEDVKGKLKNTEADLKE--SQKREAQTEAKLTEALRECESLTVSLG-----------QMKKQEKVLQE 468
Cdd:TIGR02169  914 KKRKRLSELKAKLEALEEELSEIEDPKGEdeEIPEEELSLEDVQAELQRVEEEIRALEpvnmlaiqeyeEVLKRLDELKE 993

                          250
                   ....*....|....*....
gi 1207190900  469 EVKRLTEELAEALKLIKEL 487
Cdd:TIGR02169  994 KRAKLEEERKAILERIEEY 1012
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 267-491 2.32e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 52.75  E-value: 2.32e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  267 REAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETD-RAQTAEQKVKHLQEELKcqrqnaessrcN 345
Cdd:TIGR02168  175 KETERKLERTRENLDRLEDILNELERQLKSLERQAEKAERYKELKAELRElELALLVLRLEELREELE-----------E 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  346 AEQRRKDMEREHqRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQhdkvclqKQSLERDLEDVKGKLKNTE 425
Cdd:TIGR02168  244 LQEELKEAEEEL-EELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANE-------ISRLEQQKQILRERLANLE 315

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190900  426 ADLKESQKREAQTEAKLTEALREcesltvsLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:TIGR02168  316 RQLEELEAQLEELESKLDELAEE-------LAELEEKLEELKEELESLEAELEELEAELEELESRL 374
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 353-491 2.93e-06

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 50.31  E-value: 2.93e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  353 MEREHQRELVE-QQRERQALEKQHQQEN-----NRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEA 426
Cdd:COG1579      1 AMPEDLRALLDlQELDSELDRLEHRLKElpaelAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEE 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190900  427 DLKESQK-REaqteakLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:COG1579     81 QLGNVRNnKE------YEALQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAEL 140
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 248-448 4.61e-06

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 50.98  E-value: 4.61e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLtRAQTRSTQET------------ 315
Cdd:COG3883     32 LEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREEL-GERARALYRSggsvsyldvllg 110

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  316 --------DRAQTAEQKVKHLQEELKCQrqnaessrcnaeQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQ 387
Cdd:COG3883    111 sesfsdflDRLSALSKIADADADLLEEL------------KADKAELEAKKAELEAKLAELEALKAELEAAKAELEAQQA 178

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190900  388 QARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRE 448
Cdd:COG3883    179 EQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA 239
PRK12704 PRK12704
phosphodiesterase; Provisional
 319-486 7.48e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 50.55  E-value: 7.48e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  319 QTAEQKVKHLQEELKCQRQNAESsrcNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQartlhntlqa 398
Cdd:PRK12704    38 EEAKRILEEAKKEAEAIKKEALL---EAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLEL---------- 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  399 qhdkvcLQKQslERDLEDVKGKLKNTEADLKesqKREAQTEAKLTEALRECESLTvslgQMKKQE--KVLQEEVKrltEE 476
Cdd:PRK12704   105 ------LEKR--EEELEKKEKELEQKQQELE---KKEEELEELIEEQLQELERIS----GLTAEEakEILLEKVE---EE 166

                          170
                   ....*....|.
gi 1207190900  477 L-AEALKLIKE 486
Cdd:PRK12704   167 ArHEAAVLIKE 177
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 248-790 9.62e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 50.61  E-value: 9.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQ---REAQLETERMKDVESRLAQANREisskeqSLTRTQEQLTRAQTRSTQETDRAQTAEQK 324
Cdd:pfam12128  296 DDQWKEKRDELNGELSAADaavAKDRSELEALEDQHGAFLDADIE------TAAADQEQLPSWQSELENLEERLKALTGK 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  325 VKHLQEELKCQRQNAeSSRCNAEQRRKDMEREHQRELVEQQR--ERQALEKQHQQENNRLNQEIQQARTlhntlqaqhdk 402
Cdd:pfam12128  370 HQDVTAKYNRRRSKI-KEQNNRDIAGIKDKLAKIREARDRQLavAEDDLQALESELREQLEAGKLEFNE----------- 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  403 vclQKQSLERDLEDVKGKLKNTEA------DLKESQKREAQTEAKLTEALRECESLTVSLGQMK----KQEKVLQEEVKR 472
Cdd:pfam12128  438 ---EEYRLKSRLGELKLRLNQATAtpelllQLENFDERIERAREEQEAANAEVERLQSELRQARkrrdQASEALRQASRR 514

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  473 LtEELAEALkliKELQAQLaaspppvaapnfssagdsFSPCVSLHHdrsspFNNSSQRKRAPNTGRTreeermkypsgre 552
Cdd:pfam12128  515 L-EERQSAL---DELELQL------------------FPQAGTLLH-----FLRKEAPDWEQSIGKV------------- 554

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  553 pgegIDSE--HIDKFESEEKSQKRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEDVDTDSFTSDSTRGTMPKSESDISR- 629
Cdd:pfam12128  555 ----ISPEllHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQa 630

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  630 SLKLDNTSgKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEdlETQRRAETEART---KLKQLSRKHSTQTEQQRA 706
Cdd:pfam12128  631 NGELEKAS-REETFARTALKNARLDLRRLFDEKQSEKDKKNKALA--ERKDSANERLNSleaQLKQLDKKHQAWLEEQKE 707

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  707 KALELkdSLVKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAemeqKETIMEEEMMGIKKELQDLQ 786
Cdd:pfam12128  708 QKREA--RTEKQAYWQVVEGALDAQLALLKAAIAARRSGAKAELKALETWYKRDLA----SLGVDPDVIAKLKREIRTLE 781


                   ....
gi 1207190900  787 LKLA 790
Cdd:pfam12128  782 RKIE 785
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
648-1023 1.16e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKK 727
Cdd:COG4717    134 LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQLSLATEEELQDLAEELEELQQRLAELEE 213

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  728 ESSKLKETLHALQSEAENrkVNDQEEDSQLKKALAEMEQ--------------KETIMEEEMMGIKKELQDLQLKLAQER 793
Cdd:COG4717    214 ELEEAQEELEELEEELEQ--LENELEAAALEERLKEARLllliaaallallglGGSLLSLILTIAGVLFLVLGLLALLFL 291

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  794 EEREQERLEERKLIRREEGLKIAQL-QEELDILRKSTGLEEKISKDNLPLTYLHLEHHQNTDQKADlTENKDLIPSPGVQ 872
Cdd:COG4717    292 LLAREKASLGKEAEELQALPALEELeEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAE-ELEEELQLEELEQ 370

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  873 EFSVNLQNTMVRNEAKTIELIMDLEAQTKPKtspSDMNRARALSTEASDLDNSTVLVLEVERLRAARDRESEKAKVSQRK 952
Cdd:COG4717    371 EIAALLAEAGVEDEEELRAALEQAEEYQELK---EELEELEEQLEELLGELEELLEALDEEELEEELEELEEELEELEEE 447

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1207190900  953 LEELQKQVTTQTKQLTQAFESQSkhIDNLLSELEDKECALQKQAEELQKCQEKICFLEEKQTRTNDLSAPP 1023
Cdd:COG4717    448 LEELREELAELEAELEQLEEDGE--LAELLQELEELKAELRELAEEWAALKLALELLEEAREEYREERLPP 516
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
648-782 1.56e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 1.56e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKYDLQ----KRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLE 723
Cdd:COG4913    311 LERLEARLDALREELDELEAQIRgnggDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAA 390

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  724 QEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKEL 782
Cdd:COG4913    391 ALLEALEEELEALEEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDAL 449
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 249-452 1.81e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 49.82  E-value: 1.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEqKVKHL 328
Cdd:pfam10174  485 SALQPELTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLKKAHNAEEAVRTNPEIND-RIRLL 563

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELkcQRQNAESSRCNAEQRR-----KDME-----REHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQA 398
Cdd:pfam10174  564 EQEV--ARYKEESGKAQAEVERllgilREVEnekndKDKKIAELESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEA 641

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1207190900  399 QHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESL 452
Cdd:pfam10174  642 RRREDNLADNSQQLQLEELMGALEKTRQELDATKARLSSTQQSLAEKDGHLTNL 695
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 323-491 2.37e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 49.12  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  323 QKVKHLQEELKCQRQNAESSRCNAEQRRKDME-------------REHQRELVEQQRERQALEKQHQQENNRLNQE---- 385
Cdd:pfam07888   48 QAQEAANRQREKEKERYKRDREQWERQRRELEsrvaelkeelrqsREKHEELEEKYKELSASSEELSEEKDALLAQraah 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  386 IQQARTLHNTLQAQHDKVCLQKQSLERDLEDVK---GKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQ 462
Cdd:pfam07888  128 EARIRELEEDIKTLTQRVLERETELERMKERAKkagAQRKEEEAERKQLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQ 207

                          170       180
                   ....*....|....*....|....*....
gi 1207190900  463 EKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:pfam07888  208 VLQLQDTITTLTQKLTTAHRKEAENEALL 236
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
269-490 2.80e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.86  E-value: 2.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  269 AQLETERMKDVESRLAQANREISSKEQSLTRTQEQLT--RAQTRSTQETDRAQTAEQKVKHLQEELkcqrQNAESSRCNA 346
Cdd:COG3206    163 EQNLELRREEARKALEFLEEQLPELRKELEEAEAALEefRQKNGLVDLSEEAKLLLQQLSELESQL----AEARAELAEA 238

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  347 EQRRKDMEREHQRELVEQQRERQ-ALEKQHQQENNRLNQEIQQARTlhnTLQAQHDKVclqkQSLERDLEDVKGKLKNTE 425
Cdd:COG3206    239 EARLAALRAQLGSGPDALPELLQsPVIQQLRAQLAELEAELAELSA---RYTPNHPDV----IALRAQIAALRAQLQQEA 311

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  426 ADLKESQKREAQT----EAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQ 490
Cdd:COG3206    312 QRILASLEAELEAlqarEASLQAQLAQLEARLAELPELEAELRRLEREVEVARELYESLLQRLEEARLA 380
PRK11281 PRK11281
mechanosensitive channel MscK;
648-879 3.13e-05

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 49.14  E-value: 3.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKYDLQkRLEDLETQRRAETEARTKLKQL-SRKHSTQTEQQRA-KAL-ELKDSLVKLETQLEQ 724
Cdd:PRK11281    82 TEQLKQQLAQAPAKLRQAQAELE-ALKDDNDEETRETLSTLSLRQLeSRLAQTLDQLQNAqNDLaEYNSQLVSLQTQPER 160

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  725 EKKEsskLKETLHALQsEAENRKVNDQEEDSQLK---KALAEMEQKetimeeemmgikkeLQDLQLKLAQEREEREQERL 801
Cdd:PRK11281   161 AQAA---LYANSQRLQ-QIRNLLKGGKVGGKALRpsqRVLLQAEQA--------------LLNAQNDLQRKSLEGNTQLQ 222

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190900  802 EERKLIRREEGLKIAQLQEELDILRkstgleEKISKDNLPLTYLHLEHHQNTDQKADLTENkDLIpspgVQEFSVNLQ 879
Cdd:PRK11281   223 DLLQKQRDYLTARIQRLEHQLQLLQ------EAINSKRLTLSEKTVQEAQSQDEAARIQAN-PLV----AQELEINLQ 289
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
 17-490 3.32e-05

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 49.02  E-value: 3.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   17 LQKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQ-------KHEEVRVELAAVQRELGGVREAAQAEVRTRERLSHD 89
Cdd:pfam01576   14 LQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLQaetelcaEAEEMRARLAARKQELEEILHELESRLEEEEERSQQ 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   90 LQVK----TGQVHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQkgngsgESTLFSTpcwntsspwDNNGgfRAESESKA 165
Cdd:pfam01576   94 LQNEkkkmQQHIQDLEEQLDEEEAARQKLQLEKVTTEAKIKKLE------EDILLLE---------DQNS--KLSKERKL 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  166 QHARQLQFgdvpkpsaggaSSPFPQQPYKSPPLrrhvrqsepstpssvfpwerdvlwSTPKGRPTSLVSSSEVMIKSsnc 245
Cdd:pfam01576  157 LEERISEF-----------TSNLAEEEEKAKSL------------------------SKLKNKHEAMISDLEERLKK--- 198

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  246 gmEDALRNEIDELRVRvsdLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKV 325
Cdd:pfam01576  199 --EEKGRQELEKAKRK---LEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETAQKNNALKKIRELEAQI 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  326 KHLQEELKCQRQnaesSRCNAEQRRKDMERE----------------HQREL-VEQQRERQALEKQHQQENNRLNQEIQQ 388
Cdd:pfam01576  274 SELQEDLESERA----ARNKAEKQRRDLGEElealkteledtldttaAQQELrSKREQEVTELKKALEEETRSHEAQLQE 349

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  389 ARTLHNT----LQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEK 464
Cdd:pfam01576  350 MRQKHTQaleeLTEQLEQAKRNKANLEKAKQALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRA 429

                          490       500
                   ....*....|....*....|....*.
gi 1207190900  465 VLQEEVKRLTEELAEALKLIKELQAQ 490
Cdd:pfam01576  430 ELAEKLSKLQSELESVSSLLNEAEGK 455
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 18-487 3.76e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 3.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   18 QKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELGGV---REAAQAEV----RTRERLSHDL 90
Cdd:COG1196    316 ERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAeaeLAEAEEELeelaEELLEALRAA 395

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   91 QVKTGQVHSLEGQLESAKKLTQSLTQEIKRLEAEL-------------------------EKLQKGNGSGESTLFSTPCW 145
Cdd:COG1196    396 AELAAQLEELEEAEEALLERLERLEEELEELEEALaeleeeeeeeeealeeaaeeeaeleEEEEALLELLAELLEEAALL 475

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  146 NTSspWDNNGGFRAESESKAQHARQLQFGDVPKPSAGGASSPFPQQPYKSPPLRRH-----------------VRQSEPS 208
Cdd:COG1196    476 EAA--LAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLigveaayeaaleaalaaALQNIVV 553

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  209 TPSSVFPWERDVLWSTPKGR----PTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQLETERMKDVESRLA 284
Cdd:COG1196    554 EDDEVAAAAIEYLKAAKAGRatflPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLE 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  285 QANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEElkcqrqnaessrcnaEQRRKDMEREHQRELVEQ 364
Cdd:COG1196    634 AALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAE---------------LEELAERLAEEELELEEA 698

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  365 QRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTE 444
Cdd:COG1196    699 LLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELERLEREIEA 778

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207190900  445 -------ALRECESLTVSLGQMKKQEKVLQEEVKRLteelaeaLKLIKEL 487
Cdd:COG1196    779 lgpvnllAIEEYEELEERYDFLSEQREDLEEARETL-------EEAIEEI 821
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 648-786 4.28e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.84  E-value: 4.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDvkydLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSL--VK-------L 718
Cdd:COG1579     19 LDRLEHRLKELPAELAE----LEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLgnVRnnkeyeaL 94

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190900  719 ETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQ 786
Cdd:COG1579     95 QKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEAELEELE 162
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
624-834 4.78e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 48.14  E-value: 4.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  624 ESDISRSLKLDNTSGKTEKYDSTTLKDLKKQNAELQdELRDVKYDLQKRLEDLETQRRAETEARTKLKQLsrkhstqteQ 703
Cdd:PRK03918   182 EKFIKRTENIEELIKEKEKELEEVLREINEISSELP-ELREELEKLEKEVKELEELKEEIEELEKELESL---------E 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  704 QRAKALELKdsLVKLETQLEQEKKESSKLKETLHALQS--EAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKE 781
Cdd:PRK03918   252 GSKRKLEEK--IRELEERIEELKKEIEELEEKVKELKElkEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER 329

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190900  782 LQDLQLKLAQEREEREQERLEERKLIRREEGLK----IAQLQEELDILRKSTGLEEK 834
Cdd:PRK03918   330 IKELEEKEERLEELKKKLKELEKRLEELEERHElyeeAKAKKEELERLKKRLTGLTP 386
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 249-390 4.91e-05

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 46.84  E-value: 4.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQetdrAQTAEQkVKHL 328
Cdd:COG1579     20 DRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGN----VRNNKE-YEAL 94

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207190900  329 QEE---LKCQRQNAESSRCNAEQRRKDMER---EHQRELVEQQRERQALEKQHQQENNRLNQEIQQAR 390
Cdd:COG1579     95 QKEiesLKRRISDLEDEILELMERIEELEEelaELEAELAELEAELEEKKAELDEELAELEAELEELE 162
PTZ00121 PTZ00121
MAEBL; Provisional
 256-488 5.72e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 48.21  E-value: 5.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  256 DELR----VRVSDLQREAQletERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKhlQEE 331
Cdd:PTZ00121  1537 DEAKkaeeKKKADELKKAE---ELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMK--AEE 1611

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  332 LKcqrqNAESSRCNAEQRRKDmerEHQRELVEQQRERQALEKQhQQENNRLNQEIQQARTLHNTLQAQHDKvclqkqsle 411
Cdd:PTZ00121  1612 AK----KAEEAKIKAEELKKA---EEEKKKVEQLKKKEAEEKK-KAEELKKAEEENKIKAAEEAKKAEEDK--------- 1674

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190900  412 RDLEDVKgKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQ 488
Cdd:PTZ00121  1675 KKAEEAK-KAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAK 1750
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
629-822 5.76e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 47.84  E-value: 5.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  629 RSLKLDNTSGKTEKYDSTTLKDLKKQNAELQDELRDVKyDLQKRLEDLETQRRAETEARTKLKQLSRKHstqteQQRAKA 708
Cdd:COG4717     54 EADELFKPQGRKPELNLKELKELEEELKEAEEKEEEYA-ELQEELEELEEELEELEAELEELREELEKL-----EKLLQL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  709 LELKDSLVKLETQLEQEKKESSKLKETLHALQsEAENRKVNDQEEDSQLKKALAE-MEQKETIMEEEMMGIKKELQDLQL 787
Cdd:COG4717    128 LPLYQELEALEAELAELPERLEELEERLEELR-ELEEELEELEAELAELQEELEElLEQLSLATEEELQDLAEELEELQQ 206

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1207190900  788 KLAQEREEREQERLEERKLIRREEGLKIAQLQEEL 822
Cdd:COG4717    207 RLAELEEELEEAQEELEELEEELEQLENELEAAAL 241
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 648-834 6.91e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 47.07  E-value: 6.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRkhstQTEQQRAKALELKDSLVKLETQLEQEKK 727
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQ----ELAALEAELAELEKEIAELRAELEAQKE 104

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  728 EsskLKETLHALQSEAENRKVN---DQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEER 804
Cdd:COG4942    105 E---LAELLRALYRLGRQPPLAlllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLA 181

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1207190900  805 KLIRREEGLK--IAQLQEELDILRKSTGLEEK 834
Cdd:COG4942    182 ELEEERAALEalKAERQKLLARLEKELAELAA 213
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 250-469 9.64e-05

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 45.79  E-value: 9.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  250 ALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQET-------------- 315
Cdd:pfam00261    5 QIKEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNRRIQLLEEELERTEERLAEALEKLEEAEkaadesergrkvle 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  316 DRAQTAEQKVKHLQEELKCQRQNAEssrcnaEQRRKDMEREHQRELVEQQRERqALEKQHQQENN--RLNQEIQQARTLH 393
Cdd:pfam00261   85 NRALKDEEKMEILEAQLKEAKEIAE------EADRKYEEVARKLVVVEGDLER-AEERAELAESKivELEEELKVVGNNL 157

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190900  394 NTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEakltealRECESLTVSLGQMKKQEKVLQEE 469
Cdd:pfam00261  158 KSLEASEEKASEREDKYEEQIRFLTEKLKEAETRAEFAERSVQKLE-------KEVDRLEDELEAEKEKYKAISEE 226
mukB PRK04863
chromosome partition protein MukB;
252-474 9.65e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 47.64  E-value: 9.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  252 RNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQET------DRAQT----- 320
Cdd:PRK04863   354 QADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQqavqalERAKQlcglp 433

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  321 --AEQKVKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQR-----ELV----------EQQRERQALEKQHQQENNrLN 383
Cdd:PRK04863   434 dlTADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQfeqayQLVrkiagevsrsEAWDVARELLRRLREQRH-LA 512

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  384 QEIQQARTLHNTLQAQHDkvclQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQE 463
Cdd:PRK04863   513 EQLQQLRMRLSELEQRLR----QQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQL 588

                          250
                   ....*....|.
gi 1207190900  464 KVLQEEVKRLT 474
Cdd:PRK04863   589 EQLQARIQRLA 599
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
 249-466 1.22e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 462900 [Multi-domain]  Cd Length: 305  Bit Score: 45.90  E-value: 1.22e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQRE-AQLETErMKDVEsrlAQANREISSkeqsltrTQEQLTRAQTRSTQETDRAQTAEQKVKH 327
Cdd:pfam09787   50 EELRQERDLLREEIQKLRGQiQQLRTE-LQELE---AQQQEEAES-------SREQLQELEEQLATERSARREAEAELER 118

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  328 LQEELKCQRQNAESSRCNAEQRRKDMEREHQReLVEQQRERQALEKQHQQENNRLNQ---EIQQARTLHNTLQAQHDKVC 404
Cdd:pfam09787  119 LQEELRYLEEELRRSKATLQSRIKDREAEIEK-LRNQLTSKSQSSSSQSELENRLHQlteTLIQKQTMLEALSTEKNSLV 197

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190900  405 LQKQSLERDLEDVKGKLKNTEADLKESQKREAQTE-AKLTEALRECESLTVS-LGQMKKQEKVL 466
Cdd:pfam09787  198 LQLERMEQQIKELQGEGSNGTSINMEGISDGEGTRlRNVPGLFSESDSDRAGmYGKVRKAASVI 261
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 642-1003 1.65e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.64  E-value: 1.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  642 KYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQ-QRAKA------LELKDS 714
Cdd:pfam05483  278 KLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEElNKAKAahsfvvTEFEAT 357

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  715 LVKLETQLEQEKKESSKLKETLHALQSEAENR----------KVNDQEEDSQLKKALAEME-------QKETIMEE---- 773
Cdd:pfam05483  358 TCSLEELLRTEQQRLEKNEDQLKIITMELQKKsseleemtkfKNNKEVELEELKKILAEDEklldekkQFEKIAEElkgk 437

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  774 --EMMGI----KKELQDLQLKLAQEREERE--QERLEERKLIRREEGLKIAQLQEELDILRkstgLEEKISKDNLPLTYL 845
Cdd:pfam05483  438 eqELIFLlqarEKEIHDLEIQLTAIKTSEEhyLKEVEDLKTELEKEKLKNIELTAHCDKLL----LENKELTQEASDMTL 513

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  846 HLEHHQNTDQKADLTENKDLIPSPGVQEFSVNLQNTMvrnEAKTIELIMDLEaQTKPKTSPSDMNRARALSTEASDLDNS 925
Cdd:pfam05483  514 ELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDEL---ESVREEFIQKGD-EVKCKLDKSEENARSIEYEVLKKEKQM 589

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  926 TVLVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLT--------------QAFESQSKHIDNLLSELEDKECA 991
Cdd:pfam05483  590 KILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNayeikvnklelelaSAKQKFEEIIDNYQKEIEDKKIS 669

                          410
                   ....*....|..
gi 1207190900  992 LQKQAEELQKCQ 1003
Cdd:pfam05483  670 EEKLLEEVEKAK 681
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
18-448 1.73e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 46.57  E-value: 1.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   18 QKVKQLLAQNEKLNKEKQQRQLQLDNSEVALhkqkQKHEEVRVELAAVQRELGGVREAAQAEVRTRERLSHDLQVKTGQV 97
Cdd:PRK02224   213 SELAELDEEIERYEEQREQARETRDEADEVL----EEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERL 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   98 HSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTLF--STPCWNTSSPWDNNGGFRAESESKAQHAR------ 169
Cdd:PRK02224   289 EELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEecRVAAQAHNEEAESLREDADDLEERAEELReeaael 368

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  170 ----------------QLQFGDVPKPSAGGASSPFPQQPYKSPPLRRHVRQsepstpssvfpwERDVLWSTPKGRPTSLV 233
Cdd:PRK02224   369 eseleeareavedrreEIEELEEEIEELRERFGDAPVDLGNAEDFLEELRE------------ERDELREREAELEATLR 436

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  234 SSSEVMI---------KSSNCG--MEDALRNE-IDELRVRVSDLQRE-AQLETERmKDVESR------LAQANREISSKE 294
Cdd:PRK02224   437 TARERVEeaealleagKCPECGqpVEGSPHVEtIEEDRERVEELEAElEDLEEEV-EEVEERleraedLVEAEDRIERLE 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  295 QSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQRR---KDMEREHQ------------- 358
Cdd:PRK02224   516 ERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAReevAELNSKLAelkerieslerir 595

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  359 -----RELVEQQRERQALEKQHQQENNRLNQE-IQQARTLHNTLQAQHDKVCLQ-----KQSLERDLEDVKGKLKNTEAD 427
Cdd:PRK02224   596 tllaaIADAEDEIERLREKREALAELNDERRErLAEKRERKRELEAEFDEARIEearedKERAEEYLEQVEEKLDELREE 675

                          490       500
                   ....*....|....*....|...
gi 1207190900  428 LKESQKREAQTEAKLT--EALRE 448
Cdd:PRK02224   676 RDDLQAEIGAVENELEelEELRE 698
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
249-488 1.74e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 46.57  E-value: 1.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHL 328
Cdd:PRK02224   254 ETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEEC 333

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEELKCQRQNAESSRCNAEQR--RKDMEREHQREL-VEQQRERQALEKQhQQENNRLNQEIQQARTLHNTLQAQHDKVCL 405
Cdd:PRK02224   334 RVAAQAHNEEAESLREDADDLeeRAEELREEAAELeSELEEAREAVEDR-REEIEELEEEIEELRERFGDAPVDLGNAED 412

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  406 QKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKL-----------------TEALREC----ESLTVSLGQMKKQEK 464
Cdd:PRK02224   413 FLEELREERDELREREAELEATLRTARERVEEAEALLeagkcpecgqpvegsphVETIEEDrervEELEAELEDLEEEVE 492

                          250       260
                   ....*....|....*....|....
gi 1207190900  465 VLQEEVKRLtEELAEALKLIKELQ 488
Cdd:PRK02224   493 EVEERLERA-EDLVEAEDRIERLE 515
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
249-503 1.90e-04

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 45.66  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHL 328
Cdd:COG4372     48 EQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQKERQDL 127

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  329 QEE---LKCQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCL 405
Cdd:COG4372    128 EQQrkqLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQELQALSEAEAEQALDELLKEANRNAEKEEELAEAEK 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  406 QKQSLERDLEDVKGKLKNTEAdLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIK 485
Cdd:COG4372    208 LIESLPRELAEELLEAKDSLE-AKLGLALSALLDALELEEDKEELLEEVILKEIEELELAILVEKDTEEEELEIAALELE 286

                          250
                   ....*....|....*...
gi 1207190900  486 ELQAQLAASPPPVAAPNF 503
Cdd:COG4372    287 ALEEAALELKLLALLLNL 304
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 301-486 2.12e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 46.27  E-value: 2.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  301 QEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQrqnaesSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQEnn 380
Cdd:pfam17380  298 QERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQ------AAIYAEQERMAMERERELERIRQEERKRELERIRQEE-- 369

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  381 rLNQEIQQARTLHNTLQAQHDKVCLQKQSLErdlEDVKGKLknteadLKESQKREAQTEAKLTEALRecesltvslgqmK 460
Cdd:pfam17380  370 -IAMEISRMRELERLQMERQQKNERVRQELE---AARKVKI------LEEERQRKIQQQKVEMEQIR------------A 427

                          170       180
                   ....*....|....*....|....*.
gi 1207190900  461 KQEKVLQEEVKRLTEELAEALKLIKE 486
Cdd:pfam17380  428 EQEEARQREVRRLEEERAREMERVRL 453
PRK07352 PRK07352
F0F1 ATP synthase subunit B; Validated
 267-388 2.19e-04

F0F1 ATP synthase subunit B; Validated


Pssm-ID: 180941 [Multi-domain]  Cd Length: 174  Bit Score: 43.79  E-value: 2.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  267 REAQLETErMKDVESRLAQAnreisskEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKhlQEELKCQRQNAESSRCNA 346
Cdd:PRK07352    51 RREAILQA-LKEAEERLRQA-------AQALAEAQQKLAQAQQEAERIRADAKARAEAIR--AEIEKQAIEDMARLKQTA 120

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1207190900  347 EQrrkDMEREHQRELVEQQRE--RQALEKQHQQENNRLNQEIQQ 388
Cdd:PRK07352   121 AA---DLSAEQERVIAQLRREaaELAIAKAESQLPGRLDEDAQQ 161
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
264-772 2.62e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 45.80  E-value: 2.62e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  264 DLQREAQLETERMKDVESRLAqANREISSKEQSLTRTQEQLtrAQTRSTQETDRAQTAEQKVKHLQEELK---CQRQNAE 340
Cdd:PRK02224   157 DLLQLGKLEEYRERASDARLG-VERVLSDQRGSLDQLKAQI--EEKEEKDLHERLNGLESELAELDEEIEryeEQREQAR 233

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  341 SSRCNAEQRRKDME--REHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVcLQKQSLER-DLEDV 417
Cdd:PRK02224   234 ETRDEADEVLEEHEerREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDL-LAEAGLDDaDAEAV 312

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  418 KGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQLAA--SP 495
Cdd:PRK02224   313 EARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEEleEE 392

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  496 PPVAAPNFSSAGDSFSPCVSLHHDRSSPFNNSSQRKRAPNTGRTREEERM----------KYPSGREPGEgiDSEHIDkf 565
Cdd:PRK02224   393 IEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLRTARERVeeaealleagKCPECGQPVE--GSPHVE-- 468

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  566 ESEEKSQKRIgvqtlpsgslkltefDLDTSVMEQDTGIEDVdtdsftsdstrgtmpksESDISRslkldntsgktekyds 645
Cdd:PRK02224   469 TIEEDRERVE---------------ELEAELEDLEEEVEEV-----------------EERLER---------------- 500

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  646 ttLKDLKKQNAELqDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDS-------LVKL 718
Cdd:PRK02224   501 --AEDLVEAEDRI-ERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEaeeareeVAEL 577

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190900  719 ETQLEQEKKESSKLkETLHALQSEAENrKVNDQEEDSQLKKALAEM--EQKETIME 772
Cdd:PRK02224   578 NSKLAELKERIESL-ERIRTLLAAIAD-AEDEIERLREKREALAELndERRERLAE 631
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 254-491 2.80e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 46.10  E-value: 2.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  254 EIDELRVRVSDLQR---EAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKhLQE 330
Cdd:COG3096    390 EVDSLKSQLADYQQaldVQQTRAIQYQQAVQALEKARALCGLPDLTPENAEDYLAAFRAKEQQATEEVLELEQKLS-VAD 468

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  331 ELKCQRQNA---------ESSRCNAEQRRKDMEREHqRELVEQQRERQALEKQHQQENNRLNQEiQQARTLHNTLQAQHD 401
Cdd:COG3096    469 AARRQFEKAyelvckiagEVERSQAWQTARELLRRY-RSQQALAQRLQQLRAQLAELEQRLRQQ-QNAERLLEEFCQRIG 546

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  402 KVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLtealrecESLTVSLGQMKKQEKV---LQEEVKRLTEELA 478
Cdd:COG3096    547 QQLDAAEELEELLAELEAQLEELEEQAAEAVEQRSELRQQL-------EQLRARIKELAARAPAwlaAQDALERLREQSG 619

                          250
                   ....*....|...
gi 1207190900  479 EALKLIKELQAQL 491
Cdd:COG3096    620 EALADSQEVTAAM 632
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
247-470 3.94e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 45.14  E-value: 3.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  247 MEDALRNEIDELrvrVSDLQREAQLETERMKDVESRLaqanREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVK 326
Cdd:COG4717     47 LLERLEKEADEL---FKPQGRKPELNLKELKELEEEL----KEAEEKEEEYAELQEELEELEEELEELEAELEELREELE 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  327 HLQEELKCQRQNAEssrcnaeqrrkdmEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQ 406
Cdd:COG4717    120 KLEKLLQLLPLYQE-------------LEALEAELAELPERLEELEERLEELRELEEELEELEAELAELQEELEELLEQL 186

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190900  407 KQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEV 470
Cdd:COG4717    187 SLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARL 250
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 669-1010 4.02e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.44  E-value: 4.02e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  669 LQKRLEDLETQRRAETEARTKLKQLsRKHSTQTEQQRAKALELKDSLVKLE----TQLEQEKKESSKLKETLHALQSEAE 744
Cdd:TIGR02169  172 KEKALEELEEVEENIERLDLIIDEK-RQQLERLRREREKAERYQALLKEKReyegYELLKEKEALERQKEAIERQLASLE 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  745 NRKVNDQEEDSQLKKalaEMEQKETIMEE-----------EMMGIKKELQDLQLKLAQEREEREQERLEERKLIRReegl 813
Cdd:TIGR02169  251 EELEKLTEEISELEK---RLEEIEQLLEElnkkikdlgeeEQLRVKEKIGELEAEIASLERSIAEKERELEDAEER---- 323

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  814 kIAQLQEELD-ILRKSTGLEEKISKDNLPLTYLhlehhqnTDQKADLTENKDLIPSPgVQEFSVNLQNTMVRNEAKTIEL 892
Cdd:TIGR02169  324 -LAKLEAEIDkLLAEIEELEREIEEERKRRDKL-------TEEYAELKEELEDLRAE-LEEVDKEFAETRDELKDYREKL 394

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  893 imdleAQTKPKTSPSDMNRARAlsteasdLDNSTVLVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLTQAFE 972
Cdd:TIGR02169  395 -----EKLKREINELKRELDRL-------QEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAA 462

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1207190900  973 SQSKhidnLLSELEDKECALQKQAEELQKCQEKICFLE 1010
Cdd:TIGR02169  463 DLSK----YEQELYDLKEEYDRVEKELSKLQRELAEAE 496
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 318-1015 4.81e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 44.96  E-value: 4.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  318 AQTAEQKVKHL--QEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNT 395
Cdd:pfam02463  179 IEETENLAELIidLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQ 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  396 LQAQHDKVcLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECES--LTVSLGQMKKQEKVLQEEVKRL 473
Cdd:pfam02463  259 EIEKEEEK-LAQVLKENKEEEKEKKLQEEELKLLAKEEEELKSELLKLERRKVDDEekLKESEKEKKKAEKELKKEKEEI 337

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  474 TEELAE---------ALKLIKELQAQLAASPPPVAAPNFSSAGDSFSPCVS-------LHHDRSSPFNNSSQRKRAPNTG 537
Cdd:pfam02463  338 EELEKElkeleikreAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSaaklkeeELELKSEEEKEAQLLLELARQL 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  538 RTREEERMKYPSGREPGEGIDSEHIDKFESEEKSQKRIGVQTLPS-------GSLKLTEFDLDTSVMEQDTGIEDVDTDS 610
Cdd:pfam02463  418 EDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKdelelkkSEDLLKETQLVKLQEQLELLLSRQKLEE 497

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  611 FTSDST----RGTMPKSESDISRSLKLDNTSGKTEKY-----------------DSTTLKDLKKQNAELQDELRDVKYDL 669
Cdd:pfam02463  498 RSQKESkarsGLKVLLALIKDGVGGRIISAHGRLGDLgvavenykvaistavivEVSATADEVEERQKLVRALTELPLGA 577

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  670 QKRLEDLETQRRAETEARTK--------LKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETlhALQS 741
Cdd:pfam02463  578 RKLRLLIPKLKLPLKSIAVLeidpilnlAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKG--VSLE 655

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  742 EAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEERKLIRREEGLKIAQLQEE 821
Cdd:pfam02463  656 EGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKIN 735

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  822 LDILRKSTGLEEKISKDNLPLtylhlehHQNTDQKADLTENKDLIPSPGVQEFSVNLQNTMVRNEAKTIELIMDLEAQTK 901
Cdd:pfam02463  736 EELKLLKQKIDEEEEEEEKSR-------LKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEE 808

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  902 PKTSPSDMNRARALSTEASDLDNSTVLVLEVERLRAARDRESEKAKVSQRKLEELQKQVTTQTKQLTQAFESQSKHidnl 981
Cdd:pfam02463  809 ELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKL---- 884

                          730       740       750
                   ....*....|....*....|....*....|....
gi 1207190900  982 LSELEDKECALQKQAEELQKCQEKICFLEEKQTR 1015
Cdd:pfam02463  885 KDELESKEEKEKEEKKELEEESQKLNLLEEKENE 918
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 667-840 5.03e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.76  E-value: 5.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  667 YDLQK---RLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSea 743
Cdd:COG1579     10 LDLQEldsELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRN-- 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  744 eNRKVND-QEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAqereerEQERLEERKLIRREEglKIAQLQEEL 822
Cdd:COG1579     88 -NKEYEAlQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELA------ELEAELEEKKAELDE--ELAELEAEL 158

                          170
                   ....*....|....*....
gi 1207190900  823 DILR-KSTGLEEKISKDNL 840
Cdd:COG1579    159 EELEaEREELAAKIPPELL 177
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
641-743 6.73e-04

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 440263 [Multi-domain]  Cd Length: 555  Bit Score: 44.30  E-value: 6.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  641 EKYDSTtLKDLKKQNAELQDELRDVKYDLQKRLEDLET--QRRAETEAR-TKLKQLSRKHSTQTE---------QQRAKA 708
Cdd:COG0497    257 AEYDPS-LAELAERLESALIELEEAASELRRYLDSLEFdpERLEEVEERlALLRRLARKYGVTVEellayaeelRAELAE 335

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1207190900  709 LE-LKDSLVKLETQLEQEKKESSKLKETLHALQSEA 743
Cdd:COG0497    336 LEnSDERLEELEAELAEAEAELLEAAEKLSAARKKA 371
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 647-1019 7.59e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 7.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  647 TLKDLKKQNAELqDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHST----QTEQQRAKALELKDSLVKLETQL 722
Cdd:TIGR02168  177 TERKLERTRENL-DRLEDILNELERQLKSLERQAEKAERYKELKAELRELELAllvlRLEELREELEELQEELKEAEEEL 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  723 EQEKKESSKLK---ETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAqereereqe 799
Cdd:TIGR02168  256 EELTAELQELEeklEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLE--------- 326

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  800 rLEERKLIRREEGLkiAQLQEELDILRKS-TGLEEKISKDNLPLTYLHLehhQNTDQKADLTENKDLIPSPGVQEFSvnL 878
Cdd:TIGR02168  327 -ELESKLDELAEEL--AELEEKLEELKEElESLEAELEELEAELEELES---RLEELEEQLETLRSKVAQLELQIAS--L 398

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  879 QNTMVRNEAKtielIMDLEAqtkpktspsdmnRARALSTEASDLDNSTVL--VLEVERLRAARDRESEKAKVSQRKLEEL 956
Cdd:TIGR02168  399 NNEIERLEAR----LERLED------------RRERLQQEIEELLKKLEEaeLKELQAELEELEEELEELQEELERLEEA 462

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207190900  957 QKQVTTQTKQLTQAFESQSKHIDNLLSELEdkecALQKQAEELQKCQEKICFLEEKQTRTNDL 1019
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQARLD----SLERLQENLEGFSEGVKALLKNQSGLSGI 521
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 249-488 7.73e-04

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 44.65  E-value: 7.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLT------RTQEQLTRAQTRSTQETDRAQTAE 322
Cdd:TIGR00606  740 DLKEKEIPELRNKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESAKVCLTdvtimeRFQMELKDVERKIAQQAAKLQGSD 819

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  323 ---------QKVKHLQEELKCQRQNAESSRCNAEQRRKDME---------REHQRELVEQQRERQALEKQHQQ---ENNR 381
Cdd:TIGR00606  820 ldrtvqqvnQEKQEKQHELDTVVSKIELNRKLIQDQQEQIQhlksktnelKSEKLQIGTNLQRRQQFEEQLVElstEVQS 899

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  382 LNQEIQQARTLHNTLQAQHDKVCLQKQSL-----------ERDLEDVKGKLKNTEA----------DLKESQKREAQTE- 439
Cdd:TIGR00606  900 LIREIKDAKEQDSPLETFLEKDQQEKEELissketsnkkaQDKVNDIKEKVKNIHGymkdienkiqDGKDDYLKQKETEl 979

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  440 AKLTEALRECE-----------SLTVSLGQMKKQEKVLQ---------EEVKRLTEELAEALKLIKELQ 488
Cdd:TIGR00606  980 NTVNAQLEECEkhqekinedmrLMRQDIDTQKIQERWLQdnltlrkreNELKEVEEELKQHLKEMGQMQ 1048
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
248-479 7.80e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 7.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKH 327
Cdd:PRK02224   323 DEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGD 402

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  328 LQ---EELKCQRQNAESSRCNAEQRRKDME--REHQRELVEQQRERQALEK------------------QHQQENNRLNQ 384
Cdd:PRK02224   403 APvdlGNAEDFLEELREERDELREREAELEatLRTARERVEEAEALLEAGKcpecgqpvegsphvetieEDRERVEELEA 482

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  385 EIQQARTLHNTLQAQHDKVcLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEK 464
Cdd:PRK02224   483 ELEDLEEEVEEVEERLERA-EDLVEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAA 561

                          250
                   ....*....|....*
gi 1207190900  465 VLQEEVKRLTEELAE 479
Cdd:PRK02224   562 EAEEEAEEAREEVAE 576
FapA pfam03961
Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta ...
 699-790 8.17e-04

Flagellar Assembly Protein A beta solenoid domain; This entry represents the C-terminal beta solenoid domain of FapA and its homologs. Members of this family include FapA (flagellar assembly protein A) found in Vibrio vulnificus. The synthesis of flagella allows bacteria to respond to chemotaxis by facilitating motility. Studies examining the role of FapA show that the loss or delocalization of FapA results in a complete failure of the flagellar biosynthesis and motility in response to glucose mediated chemotaxis. The polar localization of FapA is required for flagellar synthesis, and dephosphorylated EIIAGlc (Glucose-permease IIA component) inhibited the polar localization of FapA through direct interaction. This entry shows similarity to pfam03775 suggesting a similar functional role.


Pssm-ID: 461111 [Multi-domain]  Cd Length: 272  Bit Score: 43.06  E-value: 8.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  699 TQTE-QQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRkvNDQEEDSQLKKALAEMEQKETIMEEemmg 777
Cdd:pfam03961  141 TKTEiEVGVDFPELKEKLEELEKELEELEEELEKLKKRLKKLPKKARGQ--LPPEKREQLEKLLETKNKLSEELEE---- 214

                           90
                   ....*....|...
gi 1207190900  778 IKKELQDLQLKLA 790
Cdd:pfam03961  215 LEEELKELKEELE 227
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
 261-437 9.59e-04

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 464768 [Multi-domain]  Cd Length: 374  Bit Score: 43.49  E-value: 9.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  261 RVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRST--QETDRAQTAEQKVKHLQEELKCQRQN 338
Cdd:pfam15558   38 RRRDQKRQETLERERRLLLQQSQEQWQAEKEQRKARLGREERRRADRREKQVieKESRWREQAEDQENQRQEKLERARQE 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  339 AESSRCNAEQRRKDMEREHQ--RELVEQQ---RERQALEKQHQ---------QENNRLNQEIQQARTLHNTLQAQHDKVC 404
Cdd:pfam15558  118 AEQRKQCQEQRLKEKEEELQalREQNSLQlqeRLEEACHKRQLkereeqkkvQENNLSELLNHQARKVLVDCQAKAEELL 197

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1207190900  405 LQK---QSLERDLEDVKGKLKNTEADLKESQKREAQ 437
Cdd:pfam15558  198 RRLsleQSLQRSQENYEQLVEERHRELREKAQKEEE 233
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
 251-470 9.98e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 44.17  E-value: 9.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  251 LRNEIDELRVRVSDLQR---EAQL---ET--ERMKDVESRLAQAN---REISSKEQSLTRTQEQLTRAQTRSTQEtDRAQ 319
Cdd:COG3096    862 LRQQLDQLKEQLQLLNKllpQANLladETlaDRLEELREELDAAQeaqAFIQQHGKALAQLEPLVAVLQSDPEQF-EQLQ 940

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  320 TAEQKVKHLQEELKCQ-------RQN------AESSRCNAEQRRKDMEREHQRELVEQQRERQALE-KQHQQENNRLNQE 385
Cdd:COG3096    941 ADYLQAKEQQRRLKQQifalsevVQRrphfsyEDAVGLLGENSDLNEKLRARLEQAEEARREAREQlRQAQAQYSQYNQV 1020

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  386 IQQARTLHNTLQAQHdkvclqkQSLERDLEDV------------KGKLKNTEADLKESQKREAQTEAKLTEALRECESLT 453
Cdd:COG3096   1021 LASLKSSRDAKQQTL-------QELEQELEELgvqadaeaeeraRIRRDELHEELSQNRSRRSQLEKQLTRCEAEMDSLQ 1093

                          250
                   ....*....|....*..
gi 1207190900  454 VSLGQMKKQEKVLQEEV 470
Cdd:COG3096   1094 KRLRKAERDYKQEREQV 1110
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
653-827 1.04e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.85  E-value: 1.04e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  653 KQNAEL-QDELRDVKYDLQKRLEDLETQRRaetEARTKLKQLSRKHSTQTEQQRAKALElkDSLVKLETQLEQEKKESSK 731
Cdd:COG3206    163 EQNLELrREEARKALEFLEEQLPELRKELE---EAEAALEEFRQKNGLVDLSEEAKLLL--QQLSELESQLAEARAELAE 237

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  732 LKETLHALQSEAENRK-----VNDQEEDSQLKKALAEMEQKETIMEE-------EMMGIKKELQDLQLKLAQEREEREQE 799
Cdd:COG3206    238 AEARLAALRAQLGSGPdalpeLLQSPVIQQLRAQLAELEAELAELSArytpnhpDVIALRAQIAALRAQLQQEAQRILAS 317

                          170       180
                   ....*....|....*....|....*...
gi 1207190900  800 RLEERKLIRREEglkiAQLQEELDILRK 827
Cdd:COG3206    318 LEAELEALQARE----ASLQAQLAQLEA 341
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
250-786 1.21e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.88  E-value: 1.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  250 ALRNEIDELRVRVSDL--QREAQLET-ERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVK 326
Cdd:PRK02224   210 GLESELAELDEEIERYeeQREQARETrDEADEVLEEHEERREELETLEAEIEDLRETIAETEREREELAEEVRDLRERLE 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  327 HLQEELKCQRQNAESSRCNAE---QRRKDME--REHQRELVEQQRERQaleKQHQQENNRLNQEIQQARTlhntlqaqhd 401
Cdd:PRK02224   290 ELEEERDDLLAEAGLDDADAEaveARREELEdrDEELRDRLEECRVAA---QAHNEEAESLREDADDLEE---------- 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  402 kvclQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEAL 481
Cdd:PRK02224   357 ----RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELE 432

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  482 KLIKELQAQLAASPPPVAAPNFSSAGDSF--SPCVSLHHDRsspfnnssqRKRApntgRTREEERMKYPSGREPGEgids 559
Cdd:PRK02224   433 ATLRTARERVEEAEALLEAGKCPECGQPVegSPHVETIEED---------RERV----EELEAELEDLEEEVEEVE---- 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  560 EHIDKFESEEKSQKRIgvqtlpsGSLKLTEFDLDTSVMEQDTGIEDvDTDSFTSDSTRGTMPKSESDISRslklDNTSGK 639
Cdd:PRK02224   496 ERLERAEDLVEAEDRI-------ERLEERREDLEELIAERRETIEE-KRERAEELRERAAELEAEAEEKR----EAAAEA 563

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  640 TEKYDST--TLKDLKKQNAELQDELRDVKyDLQKRLEDLETQRRAETEARTKLKQLsrkhSTQTEQQRAKALELKDSLVK 717
Cdd:PRK02224   564 EEEAEEAreEVAELNSKLAELKERIESLE-RIRTLLAAIADAEDEIERLREKREAL----AELNDERRERLAEKRERKRE 638

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  718 LETQLEQEKKEssklketlhalqsEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQ 786
Cdd:PRK02224   639 LEAEFDEARIE-------------EAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELE 694
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 284-511 1.29e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 43.28  E-value: 1.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  284 AQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKcqrqnaessrcNAEQRRKDMERE--HQREL 361
Cdd:COG3883     12 AFADPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELE-----------ALQAEIDKLQAEiaEAEAE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  362 VEQQRERQALEKQHQQENNR--------LNQE-----IQQARTLhNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADL 428
Cdd:COG3883     81 IEERREELGERARALYRSGGsvsyldvlLGSEsfsdfLDRLSAL-SKIADADADLLEELKADKAELEAKKAELEAKLAEL 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  429 KESQKREAQTEAKLTEALRECESLtvsLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQLAASPPPVAAPNFSSAGD 508
Cdd:COG3883    160 EALKAELEAAKAELEAQQAEQEAL---LAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAA 236


                   ...
gi 1207190900  509 SFS 511
Cdd:COG3883    237 AAA 239
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 251-820 1.35e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 43.80  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  251 LRNEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQE 330
Cdd:TIGR00618  192 LHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEE 271

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  331 ------ELKCQRQNAESSRCNA---------EQRRKDMEREHQrELVEQQRERqALEKQHQQENNRLNQEIQQARTLHNT 395
Cdd:TIGR00618  272 lraqeaVLEETQERINRARKAAplaahikavTQIEQQAQRIHT-ELQSKMRSR-AKLLMKRAAHVKQQSSIEEQRRLLQT 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  396 LQAQHDKvclqkqsLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTealrecesltvslgqMKKQEKVLQEEVKRLTE 475
Cdd:TIGR00618  350 LHSQEIH-------IRDAHEVATSIREISCQQHTLTQHIHTLQQQKTT---------------LTQKLQSLCKELDILQR 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  476 ELAEALKLIKE---LQAQLAASPPPVAapnfssagdsfspcvsLHHDRSSPFNNSSQRKRAPNTGRTREEERMKYPSGRE 552
Cdd:TIGR00618  408 EQATIDTRTSAfrdLQGQLAHAKKQQE----------------LQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKER 471

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  553 PGEGIDSEHIDKFESEEKSQKRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEDVDTDSFTS-DSTRGTMPKSESDISRSL 631
Cdd:TIGR00618  472 EQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRRMQRgEQTYAQLETSEEDVYHQL 551

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  632 KLDNTSGKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHS------------T 699
Cdd:TIGR00618  552 TSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLrklqpeqdlqdvR 631

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  700 QTEQQRAKALELKD-SLVKLETQLEQEKKESSKLKETLHALQSEAENRKVND--QEEDSQLKKALAEMEQKETIMEEEMM 776
Cdd:TIGR00618  632 LHLQQCSQELALKLtALHALQLTLTQERVREHALSIRVLPKELLASRQLALQkmQSEKEQLTYWKEMLAQCQTLLRELET 711

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|....*..
gi 1207190900  777 GIK---KELQDLQLKLAQEREEREQERLEERKLIRREEGLKIAQLQE 820
Cdd:TIGR00618  712 HIEeydREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKA 758
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
 248-784 1.52e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 43.19  E-value: 1.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  248 EDALRNEIDELRVRVSDLQREAQLETERmkdvESRLAQANREISSKEQSLTRTQEQLTRAQTRstqetdrAQTAEQKVKH 327
Cdd:pfam05557   68 EEALREQAELNRLKKKYLEALNKKLNEK----ESQLADAREVISCLKNELSELRRQIQRAELE-------LQSTNSELEE 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  328 LQEELKCQRQNAEssrcNAEQRR-----------------KDMEREHQ-----RELVEQQRERQALEKQHQQENNRLNQE 385
Cdd:pfam05557  137 LQERLDLLKAKAS----EAEQLRqnlekqqsslaeaeqriKELEFEIQsqeqdSEIVKNSKSELARIPELEKELERLREH 212

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  386 IQQARTLHNTLQAQHDKVCLQKQSLERdLEDVKGKLKNTEADlKESQKREAQTEAKLTEA----LRECESLTVSLGQMKK 461
Cdd:pfam05557  213 NKHLNENIENKLLLKEEVEDLKRKLER-EEKYREEAATLELE-KEKLEQELQSWVKLAQDtglnLRSPEDLSRRIEQLQQ 290

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  462 QEKVLQEEVKRLTEELAEALKLIKELQAQLAASPPPVAAPNFSsagdsfspcvslhHDRSSPFNNSSQRKRapntgRTRE 541
Cdd:pfam05557  291 REIVLKEENSSLTSSARQLEKARRELEQELAQYLKKIEDLNKK-------------LKRHKALVRRLQRRV-----LLLT 352

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  542 EERMKYpsgREPGEGIDSEHIDKFESEEKSQKRIGVQTLpsgslkLTEFDLDTSVMEQDTgieDVDTDSFTSDSTRGTMP 621
Cdd:pfam05557  353 KERDGY---RAILESYDKELTMSNYSPQLLERIEEAEDM------TQKMQAHNEEMEAQL---SVAEEELGGYKQQAQTL 420

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  622 KSESDISRSLKLDNTSGKT-EKYDSttlkdLKKQNAELQ---DELRDVKYDLQKRLEDLETQRRAETeARTKLKQLSRKH 697
Cdd:pfam05557  421 ERELQALRQQESLADPSYSkEEVDS-----LRRKLETLElerQRLREQKNELEMELERRCLQGDYDP-KKTKVLHLSMNP 494

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  698 STQTEQQRAKALElkdslvKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMG 777
Cdd:pfam05557  495 AAEAYQQRKNQLE------KLQAEIERLKRLLKKLEDDLEQVLRLPETTSTMNFKEVLDLRKELESAELKNQRLKEVFQA 568


                   ....*..
gi 1207190900  778 IKKELQD 784
Cdd:pfam05557  569 KIQEFRD 575
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 253-446 1.65e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.83  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  253 NEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLtraqtrstqetdraQTAEQKVKHLQEEL 332
Cdd:COG1579     17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEI--------------EEVEARIKKYEEQL 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  333 KCQRQNaessrcnaeqrrKDMErEHQRELVEQQRERQALEKQHQQennrLNQEIQQARTLHNTLQAQHDKVclqKQSLER 412
Cdd:COG1579     83 GNVRNN------------KEYE-ALQKEIESLKRRISDLEDEILE----LMERIEELEEELAELEAELAEL---EAELEE 142

                          170       180       190
                   ....*....|....*....|....*....|....
gi 1207190900  413 DLEDVKGKLKNTEADLKESQKREAQTEAKLTEAL 446
Cdd:COG1579    143 KKAELDEELAELEAELEELEAEREELAAKIPPEL 176
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 679-1012 1.86e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 43.12  E-value: 1.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  679 QRRAETEartklKQLsrkHSTQTEQQRAKAL--ELKDSLVKLETQLEQEKK---ESSKLKETLHALQSeaeNRKVNDQEE 753
Cdd:TIGR02168  172 ERRKETE-----RKL---ERTRENLDRLEDIlnELERQLKSLERQAEKAERykeLKAELRELELALLV---LRLEELREE 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  754 DSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEERKLirreeGLKIAQLQEELDILRKStgleE 833
Cdd:TIGR02168  241 LEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYAL-----ANEISRLEQQKQILRER----L 311

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  834 KISKDNLPLTYLHLEHHQNT--DQKADLTENKDLIpspgvQEFSVNLQNTMVRNEAKTIELIMDLEAQTKPKTSPSDMNR 911
Cdd:TIGR02168  312 ANLERQLEELEAQLEELESKldELAEELAELEEKL-----EELKEELESLEAELEELEAELEELESRLEELEEQLETLRS 386

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  912 ARALSTEASDLDNSTVLVLEVERLRAARDREsekaKVSQRKLEELQKQVTTQTKQLTQAFESQSKHIDNLLSELEDKECA 991
Cdd:TIGR02168  387 KVAQLELQIASLNNEIERLEARLERLEDRRE----RLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEA 462

                          330       340
                   ....*....|....*....|.
gi 1207190900  992 LQKQAEELQKCQEKICFLEEK 1012
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERE 483
Filament pfam00038
Intermediate filament protein;
245-491 1.87e-03

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 42.21  E-value: 1.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  245 CGMEDALRNEIDELRVRVSDLQRE---AQLETERMKDvesrLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQT- 320
Cdd:pfam00038   46 SRLYSLYEKEIEDLRRQLDTLTVErarLQLELDNLRL----AAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVd 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  321 AEQKVKHLQEELKCQRQNaessrcnaeqrrkdmereHQRELVEqqrerqaLEKQHQQENnrLNQEIQQARTLH-----NT 395
Cdd:pfam00038  122 LEAKIESLKEELAFLKKN------------------HEEEVRE-------LQAQVSDTQ--VNVEMDAARKLDltsalAE 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  396 LQAQHDkvCLQKQSLERDLEDVKGKLKN--TEADLKESQKREAQTEakLTEALRECESLTVSLGQMKKQ----EKVLQEE 469
Cdd:pfam00038  175 IRAQYE--EIAAKNREEAEEWYQSKLEElqQAAARNGDALRSAKEE--ITELRRTIQSLEIELQSLKKQkaslERQLAET 250

                          250       260
                   ....*....|....*....|..
gi 1207190900  470 VKRLTEELAEALKLIKELQAQL 491
Cdd:pfam00038  251 EERYELQLADYQELISELEAEL 272
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 50-424 1.95e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.13  E-value: 1.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   50 KQKQKHEEVRVELAAVQRELggvrEAAQAEVRTRERLSHDLQVK----TGQVHSLEGQLESAKKLTQSLTQEIKRLEAEL 125
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKREL----SSLQSELRRIENRLDELSQElsdaSRKIGEIEKEIEQLEQEEEKLKERLEELEEDL 746

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  126 EKLQKGNGSGESTLfstpcwntsspwDNNGGFRAESESKAqHARQLQFGDvpkPSAGGASSPFPQQPYKSPPLRRHVRQS 205
Cdd:TIGR02169  747 SSLEQEIENVKSEL------------KELEARIEELEEDL-HKLEEALND---LEARLSHSRIPEIQAELSKLEEEVSRI 810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  206 EPSTPSSvfpwERDVLWSTPKGRPTSLVSSSEVMIKSSNCGMEDALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQ 285
Cdd:TIGR02169  811 EARLREI----EQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGD 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  286 ANREISskeqsltRTQEQLTRAQtrstQETDRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQ- 364
Cdd:TIGR02169  887 LKKERD-------ELEAQLRELE----RKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEd 955

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207190900  365 -QRERQALEKQHQQ---ENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNT 424
Cdd:TIGR02169  956 vQAELQRVEEEIRAlepVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREV 1019
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 254-491 2.25e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.57  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  254 EIDELRVRVSDLQREAQLETERMKDVESRLAQA---NREISSKEQSLTRTQEQ----LTRAQTRSTQETDRAQTAEQKVk 326
Cdd:pfam07888  151 ELERMKERAKKAGAQRKEEEAERKQLQAKLQQTeeeLRSLSKEFQELRNSLAQrdtqVLQLQDTITTLTQKLTTAHRKE- 229

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  327 hLQEELKCQRQNAESSRCNAEQRRKDMEREHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKvclQ 406
Cdd:pfam07888  230 -AENEALLEELRSLQERLNASERKVEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARWAQ---E 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  407 KQSLERDLEDVKGKLKNTEADLKesqkreaQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKE 486
Cdd:pfam07888  306 RETLQQSAEADKDRIEKLSAELQ-------RLEERLQEERMEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQK 378


                   ....*
gi 1207190900  487 LQAQL 491
Cdd:pfam07888  379 EKEQL 383
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 355-491 2.43e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 41.45  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  355 REHQRELVEQQRERQALEKQH----------QQENNRLNQEIQQARTLHNTLQAQHDKVCLQK--QSLERDLEDVKGKLK 422
Cdd:COG1579     27 KELPAELAELEDELAALEARLeaakteledlEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKeyEALQKEIESLKRRIS 106

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  423 NTEADLKESQKREAQTEAKLTEALRECESLtvslgqmKKQEKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:COG1579    107 DLEDEILELMERIEELEEELAELEAELAEL-------EAELEEKKAELDEELAELEAELEELEAEREEL 168
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 369-491 2.43e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 2.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  369 QALEKQHQQENNRLNQEIQQARTLHNtlqaqhdkvclqkqslerDLEDVKGKLKNTEADLKESQKREAQteAKLTEALRE 448
Cdd:PRK00409   526 EELERELEQKAEEAEALLKEAEKLKE------------------ELEEKKEKLQEEEDKLLEEAEKEAQ--QAIKEAKKE 585

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1207190900  449 CESLTVSLGQMKKQ------EKVLQEEVKRLT---EELAEALKLIKELQAQL 491
Cdd:PRK00409   586 ADEIIKELRQLQKGgyasvkAHELIEARKRLNkanEKKEKKKKKQKEKQEEL 637
PRK11281 PRK11281
mechanosensitive channel MscK;
1060-1311 2.53e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.59  E-value: 2.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1060 EKVSEHTVQLPVEASVIQNIDQTNT--SEISDKLQATEHFKQQsvdtsnsstASDAPI-ISDVTEEKSSsvLQDEQLNVV 1136
Cdd:PRK11281    46 DALNKQKLLEAEDKLVQQDLEQTLAllDKIDRQKEETEQLKQQ---------LAQAPAkLRQAQAELEA--LKDDNDEET 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1137 NCQNDSIPehsihdIKELER----VTKELQAAQLELNVM------------KAQN--SELALQGDMIKDKLLNVQQENQE 1198
Cdd:PRK11281   115 RETLSTLS------LRQLESrlaqTLDQLQNAQNDLAEYnsqlvslqtqpeRAQAalYANSQRLQQIRNLLKGGKVGGKA 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900 1199 LKSTLKHLCEdtgAKQDgALNLANSKNKSLLSSNEGLQSISPLGKEKLVVQHGNSEAEVQSLQEQIqklQDQILDLFEQn 1278
Cdd:PRK11281   189 LRPSQRVLLQ---AEQA-LLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTARIQRLEHQLQLLQEAI---NSKRLTLSEK- 260

                          250       260       270
                   ....*....|....*....|....*....|...
gi 1207190900 1279 rtQAEQLElwklsTVEETAGNNSPSIVLKEFEL 1311
Cdd:PRK11281   261 --TVQEAQ-----SQDEAARIQANPLVAQELEI 286
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 249-487 2.62e-03

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 42.73  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  249 DALRNEIDELRVRVSDLQREAQLETERMKDVESRLAQ-------ANR---EISSKEQSLTRTQEQLTRAQTRSTQetdrA 318
Cdd:PRK10929   105 DALEQEILQVSSQLLEKSRQAQQEQDRAREISDSLSQlpqqqteARRqlnEIERRLQTLGTPNTPLAQAQLTALQ----A 180

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  319 QTAEQKVKHLQEELK----CQRQnaESSRCNAE-----QRRKDMEREHQRELVEQQRER---QALEKQHQQENNR----- 381
Cdd:PRK10929   181 ESAALKALVDELELAqlsaNNRQ--ELARLRSElakkrSQQLDAYLQALRNQLNSQRQReaeRALESTELLAEQSgdlpk 258

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  382 -LNQEIQQARTLHNTL--QAQH-DKVCLQKQSLERDLEDVKGKLkNTeadLKEsQKREAQTEAKLTEALReceSLTVSLG 457
Cdd:PRK10929   259 sIVAQFKINRELSQALnqQAQRmDLIASQQRQAASQTLQVRQAL-NT---LRE-QSQWLGVSNALGEALR---AQVARLP 330

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1207190900  458 QMKKQEKVLQE----EVKRLT-EELAEALKLIKEL 487
Cdd:PRK10929   331 EMPKPQQLDTEmaqlRVQRLRyEDLLNKQPQLRQI 365
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
 355-491 3.08e-03

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 461130 [Multi-domain]  Cd Length: 215  Bit Score: 40.82  E-value: 3.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  355 REHQRELVEQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDK--------VCLQKQSLERDLEDVKGKLKNTEA 426
Cdd:pfam04012   32 RDMQSELVKARQALAQTIARQKQLERRLEQQTEQAKKLEEKAQAALTKgneelareALAEKKSLEKQAEALETQLAQQRS 111

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1207190900  427 DLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQAQL 491
Cdd:pfam04012  112 AVEQLRKQLAALETKIQQLKAKKNLLKARLKAAKAQEAVQTSLGSLSTSSATDSFERIEEKIEER 176
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
365-790 3.12e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 3.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  365 QRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHD---KVCLQKQSLERDLEDVKGKLKNTEADLK--ESQKREAQTE 439
Cdd:COG4717     52 EKEADELFKPQGRKPELNLKELKELEEELKEAEEKEEeyaELQEELEELEEELEELEAELEELREELEklEKLLQLLPLY 131

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  440 AKLTEALRECESLTVSLGQMKKQEKV---LQEEVKRLTEELAEALKLIKELQAQLAASPPPVAApnfssagdsfspcvsl 516
Cdd:COG4717    132 QELEALEAELAELPERLEELEERLEElreLEEELEELEAELAELQEELEELLEQLSLATEEELQ---------------- 195

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  517 hhDRSSPFNNSSQRKRAPNTGRTREEERMKypSGREPGEGIDSEHIDKFESEEKSQKRIGVQTLPSGSLKLTEFDLDTSV 596
Cdd:COG4717    196 --DLAEELEELQQRLAELEEELEEAQEELE--ELEEELEQLENELEAAALEERLKEARLLLLIAAALLALLGLGGSLLSL 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  597 MEQDTGIEDVDTDSFTSDSTRGTmpKSESDISRSLKLDNTSGKTEKYDSTTLKDLKKQNAELQDELRDVKYDLQKRLEDL 676
Cdd:COG4717    272 ILTIAGVLFLVLGLLALLFLLLA--REKASLGKEAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEEL 349

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  677 ETQRRAETEARTKLKQLSRKHSTQTEQQRAKAlELKDSLVKLETQLEQEKKESSKLKETLHALQSEA-ENRKVNDQEEDS 755
Cdd:COG4717    350 QELLREAEELEEELQLEELEQEIAALLAEAGV-EDEEELRAALEQAEEYQELKEELEELEEQLEELLgELEELLEALDEE 428

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1207190900  756 QLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLA 790
Cdd:COG4717    429 ELEEELEELEEELEELEEELEELREELAELEAELE 463
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
259-390 3.29e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 41.78  E-value: 3.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  259 RVRVSDLQREAQLET-ERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQtAEQKVKhLQEELKCQ-- 335
Cdd:COG2268    202 RIAEAEAERETEIAIaQANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAETARAE-AEAAYE-IAEANAERev 279

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1207190900  336 RQNAESSRCNAEQRRKDMERE-HQRELVEQQRERQALEKQHQQENNRLNQEIQQAR 390
Cdd:COG2268    280 QRQLEIAEREREIELQEKEAErEEAELEADVRKPAEAEKQAAEAEAEAEAEAIRAK 335
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
632-1018 3.46e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 42.33  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  632 KLDNTSGKTEKYDSTtlkdlKKQNAELQDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRK---HSTQTEQQRAKA 708
Cdd:PRK02224   214 ELAELDEEIERYEEQ-----REQARETRDEADEVLEEHEERREELETLEAEIEDLRETIAETEREreeLAEEVRDLRERL 288

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  709 LELKDSLVKLETQLEQEKKESsklkETLHALQSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLK 788
Cdd:PRK02224   289 EELEEERDDLLAEAGLDDADA----EAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELREE 364

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  789 LAQEREEREQERLEERKliRREEglkIAQLQEELDILRKSTGleekiskdNLPLTYLHLEhhqntDQKADLTENKDLIPS 868
Cdd:PRK02224   365 AAELESELEEAREAVED--RREE---IEELEEEIEELRERFG--------DAPVDLGNAE-----DFLEELREERDELRE 426

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  869 PgVQEFSVNLQNT--------MVRNEAKTIELIMDLEAQTKPKTSPSDMNRARALSTEASDLDNSTVLVLE-VERLRAAR 939
Cdd:PRK02224   427 R-EAELEATLRTArerveeaeALLEAGKCPECGQPVEGSPHVETIEEDRERVEELEAELEDLEEEVEEVEErLERAEDLV 505

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  940 DRESEKAKVSQRK--LEELQKQVTTQTKQLTQAFESQSKHIDNLLSELEDKECALQKQAEELQKCQEKICFLEEKQTRTN 1017
Cdd:PRK02224   506 EAEDRIERLEERRedLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELK 585


                   .
gi 1207190900 1018 D 1018
Cdd:PRK02224   586 E 586
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
 246-491 3.64e-03

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 42.05  E-value: 3.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  246 GMEDALRNEIDELRVRVS----DLQREAQLETERMKDVESRLAQANRE----ISSKEQSLTRTQEQLTRAQTRSTQETDR 317
Cdd:pfam07111   16 GHQDVLERRLDTQRPTVTmweqDVSGDGQGPGRRGRSLELEGSQALSQqaelISRQLQELRRLEEEVRLLRETSLQQKMR 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  318 AQTAEQKVKHLQEELKCQRQNAESSR---CNAEQRRKDMEREHQRELVEqqrerqaLEKQHQQENNRLNQEIQQARtlhn 394
Cdd:pfam07111   96 LEAQAMELDALAVAEKAGQAEAEGLRaalAGAEMVRKNLEEGSQRELEE-------IQRLHQEQLSSLTQAHEEAL---- 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  395 tlqaqhDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESLTVSLGQMKKQ--EKVLQE---- 468
Cdd:pfam07111  165 ------SSLTSKAEGLEKSLNSLETKRAGEAKQLAEAQKEAELLRKQLSKTQEELEAQVTLVESLRKYvgEQVPPEvhsq 238

                          250       260
                   ....*....|....*....|....*
gi 1207190900  469 --EVKRltEELAEALKLIKELQAQL 491
Cdd:pfam07111  239 twELER--QELLDTMQHLQEDRADL 261
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 657-827 3.73e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.03  E-value: 3.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  657 ELQDELRDVKYDLQKRleDLETQRRAETEART-KLKQLSRKHSTQTEQQRAKALELKDSLVKLETQ-LEQEKKESSKLKE 734
Cdd:pfam17380  405 KILEEERQRKIQQQKV--EMEQIRAEQEEARQrEVRRLEEERAREMERVRLEEQERQQQVERLRQQeEERKRKKLELEKE 482

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  735 TLHALQSEAENRKVNDQEEDSQlKKALAEMEQKETIMEEEMMGIKKELQDLQLKLAQEREEREQERLEERKLIRR----- 809
Cdd:pfam17380  483 KRDRKRAEEQRRKILEKELEER-KQAMIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQEqmrka 561

                          170
                   ....*....|....*....
gi 1207190900  810 -EEGLKIAQLQEELDILRK 827
Cdd:pfam17380  562 tEERSRLEAMEREREMMRQ 580
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 19-377 3.96e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 41.98  E-value: 3.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   19 KVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRELggvrEAAQAEVrtrERLSHD--LQVKTgQ 96
Cdd:TIGR02169  224 EGYELLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLL----EELNKKI---KDLGEEeqLRVKE-K 295

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   97 VHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQKGNGSGESTLfstpcwntsspwdnnGGFRAESESKAQHARQLQfgdv 176
Cdd:TIGR02169  296 IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEI---------------EELEREIEEERKRRDKLT---- 356

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  177 pkpsaggasspfpqQPYKSPPLRRHVRQSEPSTPSSVFPWERDVLwstpkgrptslvsssevmikssncgmeDALRNEID 256
Cdd:TIGR02169  357 --------------EEYAELKEELEDLRAELEEVDKEFAETRDEL---------------------------KDYREKLE 395

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  257 ELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKcqr 336
Cdd:TIGR02169  396 KLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSKYEQELY--- 472

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1207190900  337 qnaessrcnaeqRRKDMEREHQRELVEQQRERQALEKQHQQ 377
Cdd:TIGR02169  473 ------------DLKEEYDRVEKELSKLQRELAEAEAQARA 501
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
 291-464 4.07e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 41.91  E-value: 4.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  291 SSKEQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQRQNAESSRCNAEQRRKDMEREHQRE--LVEQQRER 368
Cdd:pfam05262  188 EDNEKGVNFRRDMTDLKERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAknLPKPADTS 267

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  369 QALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKvclqkqslERDLEDVKgklknteadlKESQKREAQTEAKLTEALRE 448
Cdd:pfam05262  268 SPKEDKQVAENQKREIEKAQIEIKKNDEEALKAK--------DHKAFDLK----------QESKASEKEAEDKELEAQKK 329

                          170
                   ....*....|....*.
gi 1207190900  449 CESLTVSLGQMKKQEK 464
Cdd:pfam05262  330 REPVAEDLQKTKPQVE 345
Tropomyosin pfam00261
Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 ...
 294-480 4.17e-03

Tropomyosin; Tropomyosin is an alpha-helical protein that forms a coiled-coil structure of 2 parallel helices containing 2 sets of 7 alternating actin binding sites. The protein is best known for its role in regulating the interaction between actin and myosin in muscle contraction, but is also involved in the organization and dynamics of the cytoskeleton in non-muscle cells. There are multiple cell-specific isoforms, expressed by alternative promoters and alternative RNA processing of at least four genes. Muscle isoforms of tropomyosin are characterized by having 284 amino acid residues and a highly conserved N-terminal region, whereas non-muscle forms are generally smaller and are heterogeneous in their N-terminal region.


Pssm-ID: 459736 [Multi-domain]  Cd Length: 235  Bit Score: 40.78  E-value: 4.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  294 EQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEelKCQRQNAESSRCN---AEQRRKDMEREHQRElvEQQRERQA 370
Cdd:pfam00261    7 KEELDEAEERLKEAMKKLEEAEKRAEKAEAEVAALNR--RIQLLEEELERTEerlAEALEKLEEAEKAAD--ESERGRKV 82

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  371 LEKQHQQENNRLNQeiqqartlhntLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTE------ 444
Cdd:pfam00261   83 LENRALKDEEKMEI-----------LEAQLKEAKEIAEEADRKYEEVARKLVVVEGDLERAEERAELAESKIVEleeelk 151

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1207190900  445 -ALRECESLTVSLGQMKKQEKVLQEEVKRLTEELAEA 480
Cdd:pfam00261  152 vVGNNLKSLEASEEKASEREDKYEEQIRFLTEKLKEA 188
ClyA_Cry6Aa-like cd22656
Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes ...
 682-790 4.65e-03

Bacillus thuringiensis crystal 6Aa (Cry6Aa) toxin, and similar proteins; This model includes pesticidal Cry6Aa toxin from Bacillus thuringiensis, one of the many parasporal crystal (Cry) toxins produced during the sporulation phase of growth. Many of these proteins are toxic to numerous insect species and have been effectively used as proteinaceous insecticides to directly kill insect pests; some have been used to control insect growth on transgenic agricultural plants. Cry6Aa exists as a protoxin, which is activated by cleavage using trypsin. Structure studies for Cry6Aa support a mechanism of action by pore formation, similar to cytolysin A (ClyA)-type alpha pore-forming toxins (alpha-PFTs) such as HblB, and bioassay and mutation studies show that Cry6Aa is an active pore-forming toxin. Cry6Aa shows atypical features compared to other members of alpha-PFTs, including internal repeat sequences and small loop regions within major alpha helices.


Pssm-ID: 439154 [Multi-domain]  Cd Length: 309  Bit Score: 41.20  E-value: 4.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  682 AETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKESSKLKETLHALQSEAENRKVNDQEEDsqLKKAL 761
Cdd:cd22656    111 ELEEAKKTIKALLDDLLKEAKKYQDKAAKVVDKLTDFENQTEKDQTALETLEKALKDLLTDEGGAIARKEIKD--LQKEL 188

                           90       100       110
                   ....*....|....*....|....*....|
gi 1207190900  762 AEMEQKETI-MEEEMMGIKKELQDLQLKLA 790
Cdd:cd22656    189 EKLNEEYAAkLKAKIDELKALIADDEAKLA 218
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
14-490 4.66e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.82  E-value: 4.66e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   14 GHVLQKVKQLLAQNEKLNKEKQQRQLQLDNSEVALHKQKQKHEEVRVELAAVQRElggvreaAQAEVRTRERLSHDLQVk 93
Cdd:COG4913    334 GNGGDRLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAE-------AAALLEALEEELEALEE- 405

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   94 tgQVHSLEGQLESAKKLTQSLTQEIKRLEAeleklQKGNGSGESTLfstpcwntsspwdnnggFRAESESKAQHAR-QLQ 172
Cdd:COG4913    406 --ALAEAEAALRDLRRELRELEAEIASLER-----RKSNIPARLLA-----------------LRDALAEALGLDEaELP 461

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  173 FG----DVP------KPSAGGASSPF------PQQPYK-------SPPLRRHVRqsepstpssvfpWERdVLWSTPKGRP 229
Cdd:COG4913    462 FVgeliEVRpeeerwRGAIERVLGGFaltllvPPEHYAaalrwvnRLHLRGRLV------------YER-VRTGLPDPER 528

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  230 TSLVSSS---EVMIKSSNCG--MEDALRNEIDELRVR-VSDLQREA----------QLETERMKDVESRLAQA------N 287
Cdd:COG4913    529 PRLDPDSlagKLDFKPHPFRawLEAELGRRFDYVCVDsPEELRRHPraitragqvkGNGTRHEKDDRRRIRSRyvlgfdN 608

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  288 RE-ISSKEQSLTRTQEQLTRAQtrstqetDRAQTAEQKVKHLQeelkcQRQNAESSRCNAEQRRKDMeREHQRELVEQQR 366
Cdd:COG4913    609 RAkLAALEAELAELEEELAEAE-------ERLEALEAELDALQ-----ERREALQRLAEYSWDEIDV-ASAEREIAELEA 675

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  367 ERQALEKQHqQENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEAL 446
Cdd:COG4913    676 ELERLDASS-DDLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALLEER 754

                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....
gi 1207190900  447 RECESLTVSLGQMKKQekvLQEEVKRLTEELAEALKLIKELQAQ 490
Cdd:COG4913    755 FAAALGDAVERELREN---LEERIDALRARLNRAEEELERAMRA 795
Lebercilin pfam15619
Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of ...
 648-834 5.40e-03

Ciliary protein causing Leber congenital amaurosis disease; Lebercilin is a family of eukaryotic ciliary proteins. Mutations in the gene, LCA5, are implicated in the disease Leber congenital amaurosis. In photoreceptors, lebercilin is uniquely localized at the cilium that bridges the inner and outer segments. Lebercilin functions as an integral element of selective protein transport through photoreceptor cilia. Lebercilin specifically interacts with the intraflagellar transport (IFT), and disruption of IFT can lead to Leber congenital amaurosis.


Pssm-ID: 464776 [Multi-domain]  Cd Length: 193  Bit Score: 39.89  E-value: 5.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  648 LKDLKKQNAELQDELRDVKyDLQKRlEDLETQRRAETEArtKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKK 727
Cdd:pfam15619   20 LAELQSKLEELRKENRLLK-RLQKR-QEKALGKYEGTES--ELPQLIARHNEEVRVLRERLRRLQEKERDLERKLKEKEA 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  728 ESSKLKETLHALQSEAENRKVNDQEEdsqLKKALAEMEQKetiMEEEmmgiKKELQDLQLKLAQEREEREQERLEERKLI 807
Cdd:pfam15619   96 ELLRLRDQLKRLEKLSEDKNLAEREE---LQKKLEQLEAK---LEDK----DEKIQDLERKLELENKSFRRQLAAEKKKH 165

                          170       180
                   ....*....|....*....|....*..
gi 1207190900  808 rREEGLKIAQLQEELDILRKStgLEEK 834
Cdd:pfam15619  166 -KEAQEEVKILQEEIERLQQK--LKEK 189
mukB PRK04863
chromosome partition protein MukB;
316-452 5.42e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.87  E-value: 5.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  316 DRAQTAEQKVKHLQEELKCQR--QNAESSRCNAEQRRKDMerehQRELVEQQRERQALEKQHQQENNRLNqeiqqartLH 393
Cdd:PRK04863   273 DYMRHANERRVHLEEALELRRelYTSRRQLAAEQYRLVEM----ARELAELNEAESDLEQDYQAASDHLN--------LV 340

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207190900  394 NTLQAQHDKVclqkQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEALRECESL 452
Cdd:PRK04863   341 QTALRQQEKI----ERYQADLEELEERLEEQNEVVEEADEQQEENEARAEAAEEEVDEL 395
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 253-789 5.94e-03

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 41.54  E-value: 5.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  253 NEIDELRVRVSDLQREAQLETERMKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQetdrAQTAEQKVKHLQ--- 329
Cdd:TIGR04523  145 TEIKKKEKELEKLNNKYNDLKKQKEELENELNLLEKEKLNIQKNIDKIKNKLLKLELLLSN----LKKKIQKNKSLEsqi 220

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  330 EELKCQRQNAESsrcNAEQRRKDMErEHQRELVEQQRERQALEKQHQQENNRLN---QEIQQARTLHNTLQAQHDKV--- 403
Cdd:TIGR04523  221 SELKKQNNQLKD---NIEKKQQEIN-EKTTEISNTQTQLNQLKDEQNKIKKQLSekqKELEQNNKKIKELEKQLNQLkse 296

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  404 --CLQKQSLERDLEDVKGKLKNTEADLKESQKREAQTEAKLTEalrecesLTVSLGQMKKQEKVLQEEVKRLTEELAEAL 481
Cdd:TIGR04523  297 isDLNNQKEQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQ-------LNEQISQLKKELTNSESENSEKQRELEEKQ 369

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  482 KLIKELQAQlaaspppvaapnfssagdsfspcvslhhdrsspfnNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEh 561
Cdd:TIGR04523  370 NEIEKLKKE-----------------------------------NQSYKQEIKNLESQINDLESKIQNQEKLNQQKDEQ- 413

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  562 IDKFESE----EKSQKRIGVQTLpsgSLKLTEFDLDTSVMEQDTGIEDVdtdsftsDSTRGTMPKSESDISRSLKLDNTS 637
Cdd:TIGR04523  414 IKKLQQEkellEKEIERLKETII---KNNSEIKDLTNQDSVKELIIKNL-------DNTRESLETQLKVLSRSINKIKQN 483

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  638 GKTEKydsttlKDLKKQNAELqDELRDVKYDLQKRLEDLETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVK 717
Cdd:TIGR04523  484 LEQKQ------KELKSKEKEL-KKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKDDFELKK 556

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1207190900  718 --LETQLEQEKKESSKLKETLHAL---QSEAENRKVNDQEEDSQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKL 789
Cdd:TIGR04523  557 enLEKEIDEKNKEIEELKQTQKSLkkkQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKENEKLSSII 633
mukB PRK04863
chromosome partition protein MukB;
254-489 6.69e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.48  E-value: 6.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  254 EIDELRVRVSDLQREAQLETERMKDVESRL--AQANREISSKEQSLTRtqeqltraqtRSTQETDRAQtAEQKVKHLQEE 331
Cdd:PRK04863   436 TADNAEDWLEEFQAKEQEATEELLSLEQKLsvAQAAHSQFEQAYQLVR----------KIAGEVSRSE-AWDVARELLRR 504

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  332 LKCQRQNAEssrcNAEQRR---KDMEREHQrelveQQRERQALEKQHQQENNRLNQEIQQARTLHNTLQAQHDKVCLQKQ 408
Cdd:PRK04863   505 LREQRHLAE----QLQQLRmrlSELEQRLR-----QQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSESVS 575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  409 SLERDLEDVKGKLKNTEADLKESQKREA---QTEAKLtEALREC--------ESLTVSLGQMKKQEKVLQEEVKRLTEEL 477
Cdd:PRK04863   576 EARERRMALRQQLEQLQARIQRLAARAPawlAAQDAL-ARLREQsgeefedsQDVTEYMQQLLERERELTVERDELAARK 654

                          250
                   ....*....|..
gi 1207190900  478 AEALKLIKELQA 489
Cdd:PRK04863   655 QALDEEIERLSQ 666
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 50-130 6.94e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 6.94e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900   50 KQKQKHEEVRVELAAVQRELGGVREAAQAEVRTRERLSHDLQVKTGQVHSLEGQLESAKKLTQSLTQEIKRLEAELEKLQ 129
Cdd:COG4942     24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQK 103


                   .
gi 1207190900  130 K 130
Cdd:COG4942    104 E 104
PRK12704 PRK12704
phosphodiesterase; Provisional
 649-767 7.57e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.92  E-value: 7.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  649 KDLKKQNAELQDELRDVKYDLQKRLEdlETQRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLETQLEQEKKE 728
Cdd:PRK12704    27 KIAEAKIKEAEEEAKRILEEAKKEAE--AIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLEL 104

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1207190900  729 SSKLKETLHALQSEAENRKVNDQEEDSQLKKALAEMEQK 767
Cdd:PRK12704   105 LEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQE 143
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 241-488 7.92e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.19  E-value: 7.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  241 KSSNCGMEDALRNEIDELRVRVSD--LQREAQLETER-----MKDVESRLAQANREISSKEQSLTRTQEQLTRAQTRSTQ 313
Cdd:TIGR00606  201 KVQEHQMELKYLKQYKEKACEIRDqiTSKEAQLESSReivksYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKKQ 280

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  314 -ETDRAQTAEQKVKHLQ---EELKcqrqnaessrcNAEQRRKDMEREHQRELVEQQRERQALEKQHQ---QENNRLNQEI 386
Cdd:TIGR00606  281 mEKDNSELELKMEKVFQgtdEQLN-----------DLYHNHQRTVREKERELVDCQRELEKLNKERRllnQEKTELLVEQ 349

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  387 QQARTLHNTLQAQHDKVCLQKQSLERDLE--------DVKGKLKNTEADLKESQKREAQTEAKLTEALRECESL-----T 453
Cdd:TIGR00606  350 GRLQLQADRHQEHIRARDSLIQSLATRLEldgfergpFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLkqeqaD 429

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1207190900  454 VSLGQMKKQEKVLQEEVKRLTEELAEALKLIKELQ 488
Cdd:TIGR00606  430 EIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQ 464
GBP_C pfam02841
Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral ...
 294-388 8.44e-03

Guanylate-binding protein, C-terminal domain; Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.


Pssm-ID: 460721 [Multi-domain]  Cd Length: 297  Bit Score: 40.35  E-value: 8.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  294 EQSLTRTQEQLTRAQTRSTQETDRAQTAEQKVKHLQEELKCQRQNAE----SSRCNAEQRRKDMEREHQRELVEQQR--- 366
Cdd:pfam02841  189 EEAILQTDQALTAKEKAIEAERAKAEAAEAEQELLREKQKEEEQMMEaqerSYQEHVKQLIEKMEAEREQLLAEQERmle 268

                           90       100
                   ....*....|....*....|....*..
gi 1207190900  367 -----ERQALEKQHQQENNRLNQEIQQ 388
Cdd:pfam02841  269 hklqeQEELLKEGFKTEAESLQKEIQD 295
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 338-785 9.29e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 40.82  E-value: 9.29e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  338 NAESSRCNAEQRRKDMEREHQRELVEQQRERQALekqhQQENNRLNQEIQQARTLHNTLQAQHDKVCLQKQSLERDLEDV 417
Cdd:TIGR02169  660 RAPRGGILFSRSEPAELQRLRERLEGLKRELSSL----QSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKL 735

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  418 KGKLKNTEADLKESQKREAQTEAKLTEalrecesltvslgqmkkqekvLQEEVKRLTEELAEALKLIKELQAqlaasppp 497
Cdd:TIGR02169  736 KERLEELEEDLSSLEQEIENVKSELKE---------------------LEARIEELEEDLHKLEEALNDLEA-------- 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  498 vaapnfssagdsfspcvslhHDRSSPFNNSSQRKRAPNTGRTREEERMKYPSGREPGEGIDSEHIDKfESEEKSQKRIgv 577
Cdd:TIGR02169  787 --------------------RLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEK-EIQELQEQRI-- 843

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  578 qtlpsgSLKLTEFDLDTSVMEQDTGIEDVDTdsftsdstrgtmpksesdisrslKLDNTSGKTEKYDSTtLKDLKKQNAE 657
Cdd:TIGR02169  844 ------DLKEQIKSIEKEIENLNGKKEELEE-----------------------ELEELEAALRDLESR-LGDLKKERDE 893

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  658 LQDELRdvkyDLQKRLEDLETQRRaetEARTKLKQLSRKHSTQTEQQRA--KALELKDSLVKLETQLEQEKKESSKLKET 735
Cdd:TIGR02169  894 LEAQLR----ELERKIEELEAQIE---KKRKRLSELKAKLEALEEELSEieDPKGEDEEIPEEELSLEDVQAELQRVEEE 966

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|
gi 1207190900  736 LHALqsEAENRKVNDQEEDSQlkKALAEMEQKETIMEEEMMGIKKELQDL 785
Cdd:TIGR02169  967 IRAL--EPVNMLAIQEYEEVL--KRLDELKEKRAKLEEERKAILERIEEY 1012
PLN02939 PLN02939
transferase, transferring glycosyl groups
 528-775 9.74e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 40.66  E-value: 9.74e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  528 SQRKRAPNTGRTReeeRMKYPSGREPGEGIDSEHidKFESEEKSQKRIgvQTLPSGSLKLTEFDLDTSVMEQDTGIE-DV 606
Cdd:PLN02939    16 PIRSRAPFYLPSR---RRLAVSCRARRRGFSSQQ--KKKRGKNIAPKQ--RSSNSKLQSNTDENGQLENTSLRTVMElPQ 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  607 DTDSFTSDSTRGTMPKSESDISRSLKLDNTSGKTEKYDSTTLKDLKK--QNAE----LQDELR-----DV------KYDL 669
Cdd:PLN02939    89 KSTSSDDDHNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQLEDLVGmiQNAEknilLLNQARlqaleDLekilteKEAL 168

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  670 QKRLEDLETqRRAETEARTKLKQLSRKHSTQTEQQRAKALELKDSLVKLET--------QLEQEKKESSKLKETLHALQS 741
Cdd:PLN02939   169 QGKINILEM-RLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIRGATEGlcvhslskELDVLKEENMLLKDDIQFLKA 247

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1207190900  742 ------EAENRKVNDQEEDSQLKKALAEMEQKETIMEEEM 775
Cdd:PLN02939   248 elievaETEERVFKLEKERSLLDASLRELESKFIVAQEDV 287
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 319-1019 9.95e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 40.80  E-value: 9.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  319 QTAEQKVKHLQEELKCQRQNAESSrcnAEQRRKDMEREHQRElvEQQRERQALEKQHQQENNRLnQEIQQART----LHN 394
Cdd:TIGR00606  196 QTQGQKVQEHQMELKYLKQYKEKA---CEIRDQITSKEAQLE--SSREIVKSYENELDPLKNRL-KEIEHNLSkimkLDN 269

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  395 TLQAqHDKVCLQKQSLERDLEDVKGK-LKNTEADLKESQKREAQTEAKLTEALRECESltvSLGQMKKQEKVLQEEVKRL 473
Cdd:TIGR00606  270 EIKA-LKSRKKQMEKDNSELELKMEKvFQGTDEQLNDLYHNHQRTVREKERELVDCQR---ELEKLNKERRLLNQEKTEL 345

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  474 TEELAEALKLIKELQAQLAASPPPVAAPNFSSAGDSFS--PCVSLHHDRSSPFNNSSQRKRAPNTGRTREEERMKypsgr 551
Cdd:TIGR00606  346 LVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFErgPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSK----- 420

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  552 epgEGIDSEHIDKFESEEKSQKRIGVQTLPSGSLKLTEFDLDTSVMEQDTGIEDvdtDSFTSDStrgTMPKSESDISRSL 631
Cdd:TIGR00606  421 ---ERLKQEQADEIRDEKKGLGRTIELKKEILEKKQEELKFVIKELQQLEGSSD---RILELDQ---ELRKAERELSKAE 491

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  632 KLDNTsgktekydsttlKDLKKQNAELQDELRDVKYDLQKRLEDLEtQRRAETEARTKLKQLSRKHSTQTEQQRAKALEL 711
Cdd:TIGR00606  492 KNSLT------------ETLKKEVKSLQNEKADLDRKLRKLDQEME-QLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRH 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  712 KDSLVKLETQLEQEKkessKLKETLHALQSEaenrkVNDQEED-SQLKKALAEMEQKETIMEEEMMGIKKELQDLQLKLA 790
Cdd:TIGR00606  559 SDELTSLLGYFPNKK----QLEDWLHSKSKE-----INQTRDRlAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLF 629

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  791 QEREEreqerleerklirREEGLKIAQLQEELdilrkstgleEKISKDNLPLTYLHLEHHQNTDQKADLTE------NKD 864
Cdd:TIGR00606  630 DVCGS-------------QDEESDLERLKEEI----------EKSSKQRAMLAGATAVYSQFITQLTDENQsccpvcQRV 686

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  865 LIPSPGVQEFSVNLQN-------------TMVRNEAKTIELIMDL------EAQTKPKTSPSDMNRARALSTEASDLDNS 925
Cdd:TIGR00606  687 FQTEAELQEFISDLQSklrlapdklksteSELKKKEKRRDEMLGLapgrqsIIDLKEKEIPELRNKLQKVNRDIQRLKND 766

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  926 tvlVLEVERLRAARDRESEKAKVSQRK---LEELQKQVTTQTKQLTQ-AFESQSKHIDNLLSEL----EDKECALQK--- 994
Cdd:TIGR00606  767 ---IEEQETLLGTIMPEEESAKVCLTDvtiMERFQMELKDVERKIAQqAAKLQGSDLDRTVQQVnqekQEKQHELDTvvs 843

                          730       740
                   ....*....|....*....|....*.
gi 1207190900  995 QAEELQKC-QEKICFLEEKQTRTNDL 1019
Cdd:TIGR00606  844 KIELNRKLiQDQQEQIQHLKSKTNEL 869
PRK05431 PRK05431
seryl-tRNA synthetase; Provisional
 413-491 9.97e-03

seryl-tRNA synthetase; Provisional


Pssm-ID: 235461 [Multi-domain]  Cd Length: 425  Bit Score: 40.44  E-value: 9.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207190900  413 DLEDVKGKLK--NTEADLKE-----SQKREAQTEaklTEALR-ECESLTVSLGQMKKQEK---VLQEEVKRLTEELAEAL 481
Cdd:PRK05431    10 NPEAVKEALAkrGFPLDVDElleldEERRELQTE---LEELQaERNALSKEIGQAKRKGEdaeALIAEVKELKEEIKALE 86

                           90
                   ....*....|
gi 1207190900  482 KLIKELQAQL 491
Cdd:PRK05431    87 AELDELEAEL 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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