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Conserved domains on  [gi|1207187162|ref|XP_021327089|]
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beta-1,4 N-acetylgalactosaminyltransferase 2 [Danio rerio]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 238-403 3.85e-10

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member pfam00535:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 166  Bit Score: 58.56  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 238 TIITKTFLRYEELNILLNSIRK-FYPKIKILIADDSIQPRTV--------SGDNIEHYIMPPAKGWFAGRNLALSQVETK 308
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGSTDGTVeiaeeyakKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 309 YFLWVDDDFVFLKDtRIESFVEIMEAvPELDIlggsVIGDPPYFILEYDEGDEEEGGCLSRIYNQFHQPLPGFDDCVLVD 388
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEE-DGADV----VVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIG 154

                         170
                  ....*....|....*
gi 1207187162 389 GvvnYFLARTDAVRR 403
Cdd:pfam00535 155 G---FALYRREALEE 166
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 238-403 3.85e-10

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 58.56  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 238 TIITKTFLRYEELNILLNSIRK-FYPKIKILIADDSIQPRTV--------SGDNIEHYIMPPAKGWFAGRNLALSQVETK 308
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGSTDGTVeiaeeyakKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 309 YFLWVDDDFVFLKDtRIESFVEIMEAvPELDIlggsVIGDPPYFILEYDEGDEEEGGCLSRIYNQFHQPLPGFDDCVLVD 388
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEE-DGADV----VVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIG 154

                         170
                  ....*....|....*
gi 1207187162 389 GvvnYFLARTDAVRR 403
Cdd:pfam00535 155 G---FALYRREALEE 166
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 246-343 2.70e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 52.89  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 246 RYEELNILLNSIRK-FYPKIKILIADDSIQPRTV--------SGDNIEHYIMPPAKGWFAGRNLALSQVETKYFLWVDDD 316
Cdd:cd00761     8 EEPYLERCLESLLAqTYPNFEVIVVDDGSTDGTLeileeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDAD 87

                          90       100
                  ....*....|....*....|....*..
gi 1207187162 317 FVFLKDtRIESFVEIMEAVPELDILGG 343
Cdd:cd00761    88 DLLLPD-WLERLVAELLADPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 236-354 3.94e-08

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 53.84  E-value: 3.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 236 QVTIITKTFLRYEELNILLNSIRKFYPKIKILIADDSIQP---------RTVSGDNIEHYIMPPAKGWFAGRNL-ALSQV 305
Cdd:TIGR04440   1 KLTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKfnennlkvfKNYSNPNITYLHYPDLGVPFYEKLLdALEQV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207187162 306 ETKYFLWVDDDFVFLKDTrIESFVEIMEAVPELDILGGS----------VIGDPPYFIL 354
Cdd:TIGR04440  81 ETPYVVICADDDFIIPSG-LTECLSFLEANPDYSAAQGRyvyfedrgdrVYGDQPFQYY 138
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
237-322 1.09e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 49.22  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 237 VTIITKTFLRYEELNILLNSIRKF-YPKIKILIADDSIQPRTV------SGDNIEHYIMPPAKGWFAGRNLALSQVETKY 309
Cdd:COG1216     5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNGSTDGTAellaalAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                          90
                  ....*....|...
gi 1207187162 310 FLWVDDDFVFLKD 322
Cdd:COG1216    85 LLFLDDDTVVEPD 97
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 238-403 3.85e-10

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 58.56  E-value: 3.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 238 TIITKTFLRYEELNILLNSIRK-FYPKIKILIADDSIQPRTV--------SGDNIEHYIMPPAKGWFAGRNLALSQVETK 308
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGSTDGTVeiaeeyakKDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 309 YFLWVDDDFVFLKDtRIESFVEIMEAvPELDIlggsVIGDPPYFILEYDEGDEEEGGCLSRIYNQFHQPLPGFDDCVLVD 388
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEE-DGADV----VVGSRYVIFGETGEYRRASRITLSRLPFFLGLRLLGLNLPFLIG 154

                         170
                  ....*....|....*
gi 1207187162 389 GvvnYFLARTDAVRR 403
Cdd:pfam00535 155 G---FALYRREALEE 166
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 246-343 2.70e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 52.89  E-value: 2.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 246 RYEELNILLNSIRK-FYPKIKILIADDSIQPRTV--------SGDNIEHYIMPPAKGWFAGRNLALSQVETKYFLWVDDD 316
Cdd:cd00761     8 EEPYLERCLESLLAqTYPNFEVIVVDDGSTDGTLeileeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDAD 87

                          90       100
                  ....*....|....*....|....*..
gi 1207187162 317 FVFLKDtRIESFVEIMEAVPELDILGG 343
Cdd:cd00761    88 DLLLPD-WLERLVAELLADPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 236-354 3.94e-08

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 53.84  E-value: 3.94e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 236 QVTIITKTFLRYEELNILLNSIRKFYPKIKILIADDSIQP---------RTVSGDNIEHYIMPPAKGWFAGRNL-ALSQV 305
Cdd:TIGR04440   1 KLTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKfnennlkvfKNYSNPNITYLHYPDLGVPFYEKLLdALEQV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1207187162 306 ETKYFLWVDDDFVFLKDTrIESFVEIMEAVPELDILGGS----------VIGDPPYFIL 354
Cdd:TIGR04440  81 ETPYVVICADDDFIIPSG-LTECLSFLEANPDYSAAQGRyvyfedrgdrVYGDQPFQYY 138
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
237-322 1.09e-06

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 49.22  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 237 VTIITKTFLRYEELNILLNSIRKF-YPKIKILIADDSIQPRTV------SGDNIEHYIMPPAKGWFAGRNLALSQVETKY 309
Cdd:COG1216     5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNGSTDGTAellaalAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                          90
                  ....*....|...
gi 1207187162 310 FLWVDDDFVFLKD 322
Cdd:COG1216    85 LLFLDDDTVVEPD 97
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 248-408 2.04e-05

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 45.46  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 248 EELNI--LLNSIRKF-YPKIKILIADDS--------IQPRTVSGDNIEHYIMPPAKGWFAGRNLALSQVETKYFLWVDDD 316
Cdd:COG0463    13 EEEYLeeALESLLAQtYPDFEIIVVDDGstdgtaeiLRELAAKDPRIRVIRLERNRGKGAARNAGLAAARGDYIAFLDAD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 317 FVFLKDtRIESFVEIMEAVPELDILGGSVIGDPPYFILEYDEGDEEEGGCLSRIYnqfhqplpgfddcvlvDGVVNYFLA 396
Cdd:COG0463    93 DQLDPE-KLEELVAALEEGPADLVYGSRLIREGESDLRRLGSRLFNLVRLLTNLP----------------DSTSGFRLF 155

                         170
                  ....*....|..
gi 1207187162 397 RTDAVRRVGFDP 408
Cdd:COG0463   156 RREVLEELGFDE 167
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 239-347 1.72e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 39.08  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207187162 239 IITKTFLRYEELNILLNSIRKF-YPKIKILIADDSIQPRTVS-----GDNIEHYIMPPAKGWFAGRNLALSQVETKYFLW 312
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQtYPDFEVIVVDNASTDGSVEllrelFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207187162 313 VDDDFVFLKDTrIESFVEIMEAVPELDILGGSVIG 347
Cdd:cd04186    81 LNPDTVVEPGA-LLELLDAAEQDPDVGIVGPKVSG 114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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