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Conserved domains on  [gi|1201871476|ref|XP_021246349|]
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inhibitor of Bruton tyrosine kinase [Numida meleagris]

Protein Classification

inhibitor of Bruton tyrosine kinase( domain architecture ID 13793853)

inhibitor of Bruton tyrosine kinase (IBtk) acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development; contains two BTB/POZ domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 762-874 1.42e-69

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 228.40  E-value: 1.42e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  762 KCSYLCDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDSQNVE 841
Cdd:cd18302      1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1201871476  842 FICNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18302     81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-654 4.04e-44

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 155.14  E-value: 4.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  547 FGEDFGKLLDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDsqletpdvyRKDEDAVGCDLYVIEKVHP 626
Cdd:cd18301      1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  627 DLFAYLLQFIYTDTCDLLTHGYKPKVLH 654
Cdd:cd18301     72 EIFEQLLQFIYTDTCDLLTDGYKPKLQR 99
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 870-929 3.48e-27

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


:

Pssm-ID: 350575  Cd Length: 60  Bit Score: 105.29  E-value: 3.48e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  870 LTLKNAAELLEFSATYNAEQLKLSCLQFIGLNMAALLETRTLDVLSDEVVKDLSVYYRKM 929
Cdd:cd18500      1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 145-363 1.47e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.60  E-value: 1.47e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  145 VYTWGNNINFTLGHGGQQSKHHPELVDLFPRnsvyIKQVVLCKFHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRLV 224
Cdd:COG5184     19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  225 EGLSShqCSQIAAAKDHTVALTEDGCVYTFGLNTFHQLGiLPPSANCSVPRQVQAkNLKGrmVIGVAAGRFHTVLWTKE- 303
Cdd:COG5184     95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA-GLSG--VVAIAAGGYHTCALKSDg 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1201871476  304 AVYTMGLNG-GQLGYLLDPNgekcVTGPRQVSALHhkdiSVSLVSASDGATVCVTERGDIY 363
Cdd:COG5184    169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLS----GVVAVAAGGDHSCALKSDGTVW 221
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-172 1.67e-12

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   47 IKDAFGRNVLHLASSCGKKGVLDWLAEtKGVDLLAKDKEsGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSALDL 126
Cdd:COG0666    148 AQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1201871476  127 VMKDRPVHVVFKKTDLTEVYTWGNNINFTLGHGGQQSKHHPELVDL 172
Cdd:COG0666    226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 762-874 1.42e-69

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 228.40  E-value: 1.42e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  762 KCSYLCDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDSQNVE 841
Cdd:cd18302      1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1201871476  842 FICNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18302     81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-654 4.04e-44

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 155.14  E-value: 4.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  547 FGEDFGKLLDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDsqletpdvyRKDEDAVGCDLYVIEKVHP 626
Cdd:cd18301      1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  627 DLFAYLLQFIYTDTCDLLTHGYKPKVLH 654
Cdd:cd18301     72 EIFEQLLQFIYTDTCDLLTDGYKPKLQR 99
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 870-929 3.48e-27

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 105.29  E-value: 3.48e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  870 LTLKNAAELLEFSATYNAEQLKLSCLQFIGLNMAALLETRTLDVLSDEVVKDLSVYYRKM 929
Cdd:cd18500      1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 145-363 1.47e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.60  E-value: 1.47e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  145 VYTWGNNINFTLGHGGQQSKHHPELVDLFPRnsvyIKQVVLCKFHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRLV 224
Cdd:COG5184     19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  225 EGLSShqCSQIAAAKDHTVALTEDGCVYTFGLNTFHQLGiLPPSANCSVPRQVQAkNLKGrmVIGVAAGRFHTVLWTKE- 303
Cdd:COG5184     95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA-GLSG--VVAIAAGGYHTCALKSDg 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1201871476  304 AVYTMGLNG-GQLGYLLDPNgekcVTGPRQVSALHhkdiSVSLVSASDGATVCVTERGDIY 363
Cdd:COG5184    169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLS----GVVAVAAGGDHSCALKSDGTVW 221
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 759-870 2.46e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 81.53  E-value: 2.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  759 NQKKCSYLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEalaIKDSQ 838
Cdd:pfam00651    3 ELREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEE 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1201871476  839 NVEficNVLVVADQLLISRLKEICEVAIAEKL 870
Cdd:pfam00651   79 NVD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 768-870 2.61e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.95  E-value: 2.61e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   768 DVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEalAIKDSQNVEficNV 846
Cdd:smart00225    1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFKESDK-SEIYLDdVSPEDFRALLNFLYTGK--LDLPEENVE---EL 73

                            90       100
                    ....*....|....*....|....
gi 1201871476   847 LVVADQLLISRLKEICEVAIAEKL 870
Cdd:smart00225   74 LELADYLQIPGLVELCEEFLLKLL 97
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
248-300 1.55e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.31  E-value: 1.55e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1201871476  248 DGCVYTFGLNTFHQLGiLPPSANCSVPRQVqaKNLKGRMVIGVAAGRFHTVLW 300
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKV--EGLSGNKVVQVACGGDHTVAL 50
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-172 1.67e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   47 IKDAFGRNVLHLASSCGKKGVLDWLAEtKGVDLLAKDKEsGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSALDL 126
Cdd:COG0666    148 AQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1201871476  127 VMKDRPVHVVFKKTDLTEVYTWGNNINFTLGHGGQQSKHHPELVDL 172
Cdd:COG0666    226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 555-640 2.53e-12

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 64.59  E-value: 2.53e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVYrkdedavgcdlyvIEKVHPDLFAYLLQ 634
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT-------------LDDVSPEDFEALLE 67


                   ....*.
gi 1201871476  635 FIYTDT 640
Cdd:pfam00651   68 FMYTGK 73
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 566-643 9.57e-12

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 62.71  E-value: 9.57e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476   566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVYRKDedavgcdlyviekVHPDLFAYLLQFIYTDTCDL 643
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGKLDL 65
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-117 7.84e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 7.84e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1201871476   45 ATIKDAFGRNVLHLASSCGKKGVLDWLAETKGVDllakDKESGWTALHRSIFYGYIDCVLSLLKHGVSLYIQD 117
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN----LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02713 PHA02713
hypothetical protein; Provisional
 766-868 8.35e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.93  E-value: 8.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPI-HSDILQIIVDYLYTDEAlaikDSQNVefiC 844
Cdd:PHA02713    25 LCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMfDKDAVKNIVQYLYNRHI----SSMNV---I 97

                           90       100
                   ....*....|....*....|....
gi 1201871476  845 NVLVVADQLLISRLKEICEVAIAE 868
Cdd:PHA02713    98 DVLKCADYLLIDDLVTDCESYIKD 121
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 54-124 2.23e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 2.23e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201871476   54 NVLHLASScGKKGVLDWLAETKgvdllaKDKE----SGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSAL 124
Cdd:PLN03192   528 NLLTVAST-GNAALLEELLKAK------LDPDigdsKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
 
Name Accession Description Interval E-value
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 762-874 1.42e-69

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 228.40  E-value: 1.42e-69
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  762 KCSYLCDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDSQNVE 841
Cdd:cd18302      1 KHSDLYDVTIVSEDGKEFPCHKCVLVARLEYFHSMLSSSWIEASSCSALTMPIPSDILEIILDYLYTDEASAVKESQNVE 80

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1201871476  842 FICNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18302     81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 547-654 4.04e-44

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 155.14  E-value: 4.04e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  547 FGEDFGKLLDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDsqletpdvyRKDEDAVGCDLYVIEKVHP 626
Cdd:cd18301      1 FQEDFKKLLDEADEGDNIHDVVFQVGGKTFPAHKFILASRSDYFRKLFLSSL---------LTSEDAVGCDVVHIEKVPP 71

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  627 DLFAYLLQFIYTDTCDLLTHGYKPKVLH 654
Cdd:cd18301     72 EIFEQLLQFIYTDTCDLLTDGYKPKLQR 99
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 870-929 3.48e-27

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 105.29  E-value: 3.48e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  870 LTLKNAAELLEFSATYNAEQLKLSCLQFIGLNMAALLETRTLDVLSDEVVKDLSVYYRKM 929
Cdd:cd18500      1 ITLRNVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKELSKYYREM 60
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 145-363 1.47e-24

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 106.60  E-value: 1.47e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  145 VYTWGNNINFTLGHGGQQSKHHPELVDLFPRnsvyIKQVVLCKFHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRLV 224
Cdd:COG5184     19 VWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN----VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  225 EGLSShqCSQIAAAKDHTVALTEDGCVYTFGLNTFHQLGiLPPSANCSVPRQVQAkNLKGrmVIGVAAGRFHTVLWTKE- 303
Cdd:COG5184     95 PGLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG-DGTTTNRLTPVQVDA-GLSG--VVAIAAGGYHTCALKSDg 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1201871476  304 AVYTMGLNG-GQLGYLLDPNgekcVTGPRQVSALHhkdiSVSLVSASDGATVCVTERGDIY 363
Cdd:COG5184    169 TVWCWGANSyGQLGDGTTTD----RPTPVQVGGLS----GVVAVAAGGDHSCALKSDGTVW 221
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-316 6.78e-23

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 101.59  E-value: 6.78e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  144 EVYTWGNNINFTLGHGGQQSKHHPELVDLFPRnsvyIKQVVLCKFHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRL 223
Cdd:COG5184    169 TVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG----VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQ 244

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  224 VEGLSSHQcsQIAAAKDHTVALTEDGCVYTFGLNTFHQLGIlPPSANCSVPRQVQakNLKGrmVIGVAAGRFHTVLWTKE 303
Cdd:COG5184    245 VAGLTGVV--AIAAGGSHTCALKSDGTVWCWGDNSYGQLGD-GTTTDRSTPVKVP--GLSG--VVAVAAGSSHTCALLTD 317

                          170
                   ....*....|....*
gi 1201871476  304 -AVYTMGLNG-GQLG 316
Cdd:COG5184    318 gTVWCWGDNAyGQLG 332
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-853 1.21e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 87.22  E-value: 1.21e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEAlaikdSQNVEFIC 844
Cdd:cd18186      1 LCDVTLVV-GGREFPAHRAVLAARSPYFRAMFSSGMKESSS-SEIELDdVSPEAFEALLDYIYTGEL-----ELSEENVE 73


                   ....*....
gi 1201871476  845 NVLVVADQL 853
Cdd:cd18186     74 ELLAAADKL 82
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-355 2.89e-20

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 93.89  E-value: 2.89e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  144 EVYTWGNNINFTLGHGGQQSKHHPELVDLFPRnsvyIKQVVLCKFHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRL 223
Cdd:COG5184     68 TVWCWGNNSYGQLGDGTTTDRTTPVKVPGLTG----VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQ 143

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  224 V-EGLSShqCSQIAAAKDHTVALTEDGCVYTFGLNTFHQLGiLPPSANCSVPRQVQAknLKGrmVIGVAAGRFHT-VLWT 301
Cdd:COG5184    144 VdAGLSG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLG-DGTTTDRPTPVQVGG--LSG--VVAVAAGGDHScALKS 216

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  302 KEAVYTMGLNG-GQLGYLLDPNgekcVTGPRQVSALHH-KDISV----SLVSASDGATVC 355
Cdd:COG5184    217 DGTVWCWGSNSsGQLGDGTTTD----RATPVQVAGLTGvVAIAAggshTCALKSDGTVWC 272
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 759-870 2.46e-18

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 81.53  E-value: 2.46e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  759 NQKKCSYLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEalaIKDSQ 838
Cdd:pfam00651    3 ELREQGELCDVTLVV-GDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDDVSPEDFEALLEFMYTGK---LISEE 78

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1201871476  839 NVEficNVLVVADQLLISRLKEICEVAIAEKL 870
Cdd:pfam00651   79 NVD---DLLAAADKLQIPSLVDKCEEFLIKSL 107
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 188-363 3.05e-18

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 87.72  E-value: 3.05e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  188 FHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRLVEGLSShqCSQIAAAKDHTVALTEDGCVYTFGLNTFHQLGiLPP 267
Cdd:COG5184      8 SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLG-DGT 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  268 SANCSVPRQVqaKNLKGrmVIGVAAGRFHT-VLWTKEAVYTMGLNG-GQLGYLLDPNgekcVTGPRQVSAlhhKDISVSL 345
Cdd:COG5184     85 TTDRTTPVKV--PGLTG--VVAVAAGYYHScALKSDGTVWCWGDNSsGQLGDGTTTN----RLTPVQVDA---GLSGVVA 153

                          170
                   ....*....|....*...
gi 1201871476  346 VSASDGATVCVTERGDIY 363
Cdd:COG5184    154 IAAGGYHTCALKSDGTVW 171
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 144-274 1.36e-16

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 82.72  E-value: 1.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  144 EVYTWGNNINFTLGHGGQQSKHHPELVDlfprNSVYIKQVVLCKFHSVFLSHKGQIYTCGHGQGGRLGHGDEQTCLVPRL 223
Cdd:COG5184    219 TVWCWGSNSSGQLGDGTTTDRATPVQVA----GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVK 294

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1201871476  224 VEGLSshQCSQIAAAKDHTVALTEDGCVYTFGLNTFHQLGIlPPSANCSVP 274
Cdd:COG5184    295 VPGLS--GVVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGD-GTTTDRSTP 342
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 756-870 4.11e-16

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 75.79  E-value: 4.11e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  756 LKFNQKKCSYLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSAlEMP------IHSDILQIIVDYLYTD 829
Cdd:cd18296      7 LPFPPEQELSFPDVCFQV-EGHRFPCHKAFFCGRSDYFKALLRDHFAESEENNG-SIPvvtlhdVSPEVFAIVLYYIYTD 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1201871476  830 EALAikdsqNVEFICNVLVVADQLLISRLKEICEVAIAEKL 870
Cdd:cd18296     85 DTDL-----PPENAYDVLYVADMYLLPGLKRLCGTVLAQSL 120
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 2.39e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 69.50  E-value: 2.39e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18186      3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEI-------------ELDDVSPEAFEALLDYIYTGELEL 67
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 768-870 2.61e-13

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 66.95  E-value: 2.61e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   768 DVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEalAIKDSQNVEficNV 846
Cdd:smart00225    1 DVTLVV-GGKKFHAHKAVLAAHSPYFKALFSSDFKESDK-SEIYLDdVSPEDFRALLNFLYTGK--LDLPEENVE---EL 73

                            90       100
                    ....*....|....*....|....
gi 1201871476   847 LVVADQLLISRLKEICEVAIAEKL 870
Cdd:smart00225   74 LELADYLQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-874 2.90e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 67.74  E-value: 2.90e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEaSSCSALEMP-IHSDILQIIVDYLYTDEALAikDSQNVEfic 844
Cdd:cd18240     17 LCDVVIRV-NGVEFPAHRNILCACSPYFRALFTNGWNE-TEKKVYKIPgVSPEMMELIIEYAYTRTVPI--TAENVE--- 89

                           90       100       110
                   ....*....|....*....|....*....|
gi 1201871476  845 NVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18240     90 ELLPAADQFNIMGIVKACCDFLEDQLCPEN 119
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-874 6.79e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 67.12  E-value: 6.79e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDSqnvefICN 845
Cdd:cd18268     23 LTDVIL-CTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLKGIDSDVLDQIVDYVYTGEILITRDN-----VLP 96

                           90       100
                   ....*....|....*....|....*....
gi 1201871476  846 VLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18268     97 LMEAASMLQYPKLFEACSLYLQDQLTPEN 125
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 758-861 1.29e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 65.74  E-value: 1.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  758 FNQKKCSylcDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCsalEMPI----HSDILqIIVDYLYTDeALA 833
Cdd:cd18286     12 FLNGEDS---DITIKV-DGKTFKAHRCILCARSSYFAAMLSGSWAESNSS---EITLtgvsHAAVS-FVLLFIYGG-VLD 82

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  834 IKDSQNvefICNVLVVADQLLISRLKEI 861
Cdd:cd18286     83 LPDDVN---LGELLSLADMYGLDGLKDV 107
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
248-300 1.55e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.31  E-value: 1.55e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1201871476  248 DGCVYTFGLNTFHQLGiLPPSANCSVPRQVqaKNLKGRMVIGVAAGRFHTVLW 300
Cdd:pfam00415    1 DGRVYTWGRNDYGQLG-LGTTENVLVPQKV--EGLSGNKVVQVACGGDHTVAL 50
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
47-172 1.67e-12

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   47 IKDAFGRNVLHLASSCGKKGVLDWLAEtKGVDLLAKDKEsGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSALDL 126
Cdd:COG0666    148 AQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARDND-GETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1201871476  127 VMKDRPVHVVFKKTDLTEVYTWGNNINFTLGHGGQQSKHHPELVDL 172
Cdd:COG0666    226 AAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLL 271
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 555-640 2.53e-12

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 64.59  E-value: 2.53e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVYrkdedavgcdlyvIEKVHPDLFAYLLQ 634
Cdd:pfam00651    1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEIT-------------LDDVSPEDFEALLE 67


                   ....*.
gi 1201871476  635 FIYTDT 640
Cdd:pfam00651   68 FMYTGK 73
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
196-245 3.08e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 62.53  E-value: 3.08e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1201871476  196 KGQIYTCGHGQGGRLGHGDEQTCLVPRLVEGLSSHQCSQIAAAKDHTVAL 245
Cdd:pfam00415    1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 566-643 9.57e-12

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 62.71  E-value: 9.57e-12
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476   566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVYRKDedavgcdlyviekVHPDLFAYLLQFIYTDTCDL 643
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-------------VSPEDFRALLNFLYTGKLDL 65
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 550-643 1.99e-11

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 62.31  E-value: 1.99e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  550 DFGKLLDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVS--SDSQLETPdvyrkdedavGCDLYVIEKVHPD 627
Cdd:cd18296      3 DLDELPFPPEQELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDhfAESEENNG----------SIPVVTLHDVSPE 72

                           90
                   ....*....|....*.
gi 1201871476  628 LFAYLLQFIYTDTCDL 643
Cdd:cd18296     73 VFAIVLYYIYTDDTDL 88
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-874 3.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 62.18  E-value: 3.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLCDVTL--KSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMPIHS-------DILQIIVDYLYTDE 830
Cdd:cd18241     17 QRKQGLFCDITLafGGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRS-GRVEMRKWSsepgpdpDTVEAVIQYMYTGR 95

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1201871476  831 alaIKDSQ-NVEficNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18241     96 ---IRVSTgNVH---EVLELADRFLLIRLKEFCGEFLKKKLNLSN 134
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 548-640 4.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 61.58  E-value: 4.03e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  548 GEDFGKLLDetDEMDSihDVTLQIGTRTYAVHKYILAVRSDFFKklfvssdSQLETPDVYRKDEDAvgcdlyVIEKVHPD 627
Cdd:cd18280      2 GQHFGALLE--SEEGA--DVTFNVDGEKFRAHKLVLAARSPVFR-------SMLFGPMREENEGEI------VIEDVEPP 64

                           90
                   ....*....|...
gi 1201871476  628 LFAYLLQFIYTDT 640
Cdd:cd18280     65 VFKALLHFIYKDE 77
Ank_2 pfam12796
Ankyrin repeats (3 copies);
45-117 7.84e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.74  E-value: 7.84e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1201871476   45 ATIKDAFGRNVLHLASSCGKKGVLDWLAETKGVDllakDKESGWTALHRSIFYGYIDCVLSLLKHGVSLYIQD 117
Cdd:pfam12796   23 ANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN----LKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 759-874 9.72e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 60.58  E-value: 9.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  759 NQKKCSYLCDVTLKSSdGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIkDSQ 838
Cdd:cd18237     14 NMRKQKTLCDVILIVE-GREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKDAEPDIIELLVEFAYTAR-ISV-NSN 90

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1201871476  839 NVEficNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18237     91 NVQ---SLLDAANQYQIEPVKKMCVDFLKEQLDASN 123
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 233-355 9.91e-11

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 65.00  E-value: 9.91e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  233 SQIAAAKDHTVALTEDGCVYTFGLNTFHQLGIlPPSANCSVPRQVQakNLKGrmVIGVAAGRFHT-VLWTKEAVYTMGLN 311
Cdd:COG5184      1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGD-GTTTDRSTPVRVP--GLSN--VVAVAAGGDHTcALKADGTVWCWGNN 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1201871476  312 G-GQLGylldpNGEK-CVTGPRQVSALHH-KDISV----SLVSASDGATVC 355
Cdd:COG5184     76 SyGQLG-----DGTTtDRTTPVKVPGLTGvVAVAAgyyhSCALKSDGTVWC 121
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-862 1.12e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 59.99  E-value: 1.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIkDSQNVEficN 845
Cdd:cd18247     19 LCDVTLKVGD-QKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQGIEPSALEALINFAYSGR-IAI-DTSNVQ---S 92

                           90
                   ....*....|....*..
gi 1201871476  846 VLVVADQLLISRLKEIC 862
Cdd:cd18247     93 LLVGASFLQLQSVKDAC 109
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 758-863 2.49e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 59.18  E-value: 2.49e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  758 FNQKKcsyLCDVT-LKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALE-MPIHSDILQIIVDYLYTDEAlaik 835
Cdd:cd18294      9 INNPE---FSDVKfLVGPERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVlSDIEPEVFRAVLEFIYTNCV---- 81

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  836 dSQNVEFICNVLVVADQLLISRLKEICE 863
Cdd:cd18294     82 -TLSNHTVIEVLAAAVEYGLDELRKLCE 108
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-124 2.81e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 63.05  E-value: 2.81e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   43 NAATIKDAFGRNVLHLASSCGKKGVLDWLAEtKGVDLLAKDKEsGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLS 122
Cdd:COG0666     78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLE-AGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNT 155


                   ..
gi 1201871476  123 AL 124
Cdd:COG0666    156 PL 157
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-874 4.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 59.07  E-value: 4.21e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEALAIKdsQNVEficNV 846
Cdd:cd18252     23 DITLQCASGQIFHCHKAALAACSSYFKVMFTADMKEKSN-NVIKLSgIDHDILEALVNYVYTSQICITE--RNVQ---SL 96

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  847 LVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18252     97 LEAADLLQFISVKKACEQFLVRHLDIDN 124
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-830 5.62e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 58.61  E-value: 5.62e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  761 KKCSYLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDE 830
Cdd:cd18242     16 RKSNTLCDVTLRV-EGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYTET 84
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-862 8.40e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 57.35  E-value: 8.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSW-IEASSCSALE-MPIHSDILQIIVDYLYTDEalaIKDSQnvEFI 843
Cdd:cd18245     14 LCDATL-VVGGEEIPVQKNVLAAASPYFRAKLNYNPpKDDGSTYKIElEGISVEVMEEILDYIYTGQ---IKLSE--DNI 87

                           90
                   ....*....|....*....
gi 1201871476  844 CNVLVVADQLLISRLKEIC 862
Cdd:cd18245     88 QDIVQAADLLLMTDLKDLC 106
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-862 1.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 57.47  E-value: 1.19e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYtdEALAIKDSQNVEficN 845
Cdd:cd18265     23 FTDVVLLV-DGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAAAMEVLLDYMY--GGGLRIQEDNVE---S 96

                           90
                   ....*....|....*..
gi 1201871476  846 VLVVADQLLISRLKEIC 862
Cdd:cd18265     97 VLEASDLLQVSKLREAC 113
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 766-870 1.60e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 56.48  E-value: 1.60e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEalaIKDSQNVEFIC 844
Cdd:cd18300      9 FSDVTFIVEDGT-IPAHKALLVARCDVMAAMFGGNFRESSA-KEVELPgVSKETFLALLEYLYTDQ---APILEDGDCVG 83

                           90       100
                   ....*....|....*....|....*.
gi 1201871476  845 nVLVVADQLLISRLKEICEVAIAEKL 870
Cdd:cd18300     84 -LIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-875 2.59e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 56.70  E-value: 2.59e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLcDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEAsscSALEMPIHS---DILQIIVDYLYTDEALAIKD 836
Cdd:cd18250     16 RAERKFF-DVTL-CAGGREFPCHRTVLAAASSYFRAMFAGELRES---RADRVVLHGvsaEILGLLLDFSYTGRVTVTQD 90

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1201871476  837 sqNVEFIcnvLVVADQLLISRLKEICEVAIAEKLTLKNA 875
Cdd:cd18250     91 --NVEAL---LRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-874 3.16e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 56.13  E-value: 3.16e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  776 GKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEALAIKDSQNVefICNVLVVADQLL 854
Cdd:cd18297     21 GRPFYAHKIVLVTASDRFKSMLSSGSTEAQT-PVIEIPdIRYDIFQLMMQYLYTGGVESLDVAQDD--ALELLRAASFFQ 97

                           90       100
                   ....*....|....*....|
gi 1201871476  855 ISRLKEICEVAIAEKLTLKN 874
Cdd:cd18297     98 LDGLKRHCEILLSQQIDLDN 117
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 763-879 3.45e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 56.76  E-value: 3.45e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  763 CSYLCDVTLK-------SSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEalAIK 835
Cdd:cd18273     23 ARLLTDVTIEvngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHDVDSESMALIIDYCYTGR--VTL 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1201871476  836 DSQNVEficNVLVVADQLLISRLKEICEVAIAEKLTLKNAAELL 879
Cdd:cd18273    101 SEANVQ---RLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-828 4.25e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 55.76  E-value: 4.25e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1201871476  765 YLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSaleMPIH---SDILQIIVDYLYT 828
Cdd:cd18238     14 ELCDVTLKV-GEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDS---ITIKdidEEAVELLVDFAYT 76
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-646 5.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 55.49  E-value: 5.70e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYLLQFIYTDTCDLLT 645
Cdd:cd18256     22 DVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVV-------------QIHGVEPDIFHILLDFIYTGVVEVTV 88


                   .
gi 1201871476  646 H 646
Cdd:cd18256     89 S 89
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-874 1.70e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 54.47  E-value: 1.70e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKdsQNVEficN 845
Cdd:cd18236     24 LTDVIL-CVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIKGVDAETMQILLDYTYTSKVLITK--QNVQ---R 97

                           90       100
                   ....*....|....*....|....*....
gi 1201871476  846 VLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18236     98 VLEAASLFQFLRMVDACASFLTEALHPEN 126
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 754-862 2.37e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 53.95  E-value: 2.37e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  754 NKLKFNQKkcsyLCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLA 833
Cdd:cd18256     12 NKLRGQHE----FCDVQLQVGMEL-FSVHRLVLAASSPYFAALFAGGMSESSKDVVQIHGVEPDIFHILLDFIYTGV-VE 85

                           90       100
                   ....*....|....*....|....*....
gi 1201871476  834 IKDSqNVEficNVLVVADQLLISRLKEIC 862
Cdd:cd18256     86 VTVS-NVQ---ELLVAADMLQLTEVVEIC 110
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 566-638 4.49e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 51.96  E-value: 4.49e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYLLQFIYT 638
Cdd:cd18314      8 DVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEV-------------TLEDVEPEIFETVLKYMYT 67
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 758-874 8.62e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 51.94  E-value: 8.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  758 FNQKKCSylcDVTLKSSDgKEFPCHKCVLCARldyfhsmlSSSWIEASSCSALEMPIhSDILQ----IIVDYLYTDEala 833
Cdd:cd18303     13 FDKELYS---DITIKLAD-KSIPAHKFVLAAR--------SEKWSNENLASTNELDL-SDISYevvlALLRWLYTDE--- 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1201871476  834 IKDSQNVEFICNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18303     77 LDLTLDDEFLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-858 9.42e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 52.30  E-value: 9.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSY----LCDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIK 835
Cdd:cd18274     12 QLKAMYdegqLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMHLVLDYAYTSRVTLTE 91

                           90       100       110
                   ....*....|....*....|....*....|
gi 1201871476  836 DSQNVEF----ICNVLVVADQ---LLISRL 858
Cdd:cd18274     92 ANVQALFtaasIFQIPSLQDQcaqFMISRL 121
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 764-874 9.51e-08

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 51.71  E-value: 9.51e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  764 SYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEALAIKDSQNvef 842
Cdd:cd18352     11 ATLSDVTF-LVEGRRFYAHRIALLASSDAFRAMFDGGYREKEA-RDIEIPnIRWEVFELMMRFIYTGSVDITNDIAK--- 85

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1201871476  843 icNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18352     86 --DLLRAADQYLLEGLKRLCEYTIAQDLTLEN 115
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-878 1.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 51.88  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTdealaikdSQ- 838
Cdd:cd18306     12 LRKNRQFCDVIL-QVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT--------SRl 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1201871476  839 --NVEFICNVLVVADQLLISRLKEICEVAIAEKLTLKNAAEL 878
Cdd:cd18306     83 evPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 547-646 1.15e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 51.48  E-value: 1.15e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  547 FGEDFGKLLDetdeMDSIHDVTLQIG-TRT--YAvHKYILAVRSDFFKKLFV---SSDSQLETpdvyrkdedavgcdlYV 620
Cdd:cd18294      1 FAADMKSLIN----NPEFSDVKFLVGpERQeiFA-HKCILAARCEVFRAMFLtgpQKESTQSP---------------LV 60

                           90       100
                   ....*....|....*....|....*.
gi 1201871476  621 IEKVHPDLFAYLLQFIYTDTCDLLTH 646
Cdd:cd18294     61 LSDIEPEVFRAVLEFIYTNCVTLSNH 86
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-862 1.59e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 51.27  E-value: 1.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  761 KKCSYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDsqNV 840
Cdd:cd18235     16 RKQNLLCDVIL-VADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEE--NV 92

                           90       100
                   ....*....|....*....|...
gi 1201871476  841 EficnVLVVADQLL-ISRLKEIC 862
Cdd:cd18235     93 Q----VLLPAANLLqLTDVRDAC 111
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-862 1.61e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 51.33  E-value: 1.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMP-IHSDILQIIVDYLYTDEaLAIKdSQ 838
Cdd:cd18293      9 QQNSGVFCDVLLQA-EGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQgLKAHTLLKLVDFLYTSE-LEVS-SE 85

                           90       100
                   ....*....|....*....|....
gi 1201871476  839 NVEficNVLVVADQLLISRLKEIC 862
Cdd:cd18293     86 EAQ---DVLAAARRLQISELESLC 106
Ank_5 pfam13857
Ankyrin repeats (many copies);
71-127 2.63e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.50  E-value: 2.63e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1201871476   71 LAETKGVDLLAKDKEsGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSALDLV 127
Cdd:pfam13857    1 LLEHGPIDLNRLDGE-GYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-875 2.86e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 50.62  E-value: 2.86e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSwIEASSCSALEMP-IHSDILQIIVDYLYTDEAlaikdsQNVEFICN- 845
Cdd:cd18345     20 DVTL-CVGGREFQAHKAILAARSPVFNAMFEHE-MEERKQNRVEITdVDHEVMREMLRFIYTGKA------PNLDKMADd 91

                           90       100       110
                   ....*....|....*....|....*....|
gi 1201871476  846 VLVVADQLLISRLKEICEVAIAEKLTLKNA 875
Cdd:cd18345     92 LLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-874 2.96e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 50.47  E-value: 2.96e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEaSSCSALEMP-IHSDILQIIVDYLYTDEaLAIkDSQNVEfic 844
Cdd:cd18255     18 LLDVTL-IADGQRFQAHKVVLASCSDYFRAMFTGGMRE-SSQDEIELKgVSAKGLKHILDFAYTSE-LTL-DLDCIQ--- 90

                           90       100       110
                   ....*....|....*....|....*....|
gi 1201871476  845 NVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18255     91 DVLGAAVHLQMLPVVELCEEFLKSAMSVEN 120
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 755-879 3.04e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 50.77  E-value: 3.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  755 KLKFNQKkcsYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAI 834
Cdd:cd18270     18 KFFYEQQ---LLTDIVL-IVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGN-LAI 92

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1201871476  835 KDS---QNVEFICnVLVVADQLLISRlkeicEVAIaEKLTLKNAAELL 879
Cdd:cd18270     93 NDStveQLYETAC-FLQVEDVLQRCR-----EYLI-KKINAENCVRLL 133
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 766-870 3.09e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 50.23  E-value: 3.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSdGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSaleMPIH---SDILQIIVDYLYTDEALAIKDSQNVef 842
Cdd:cd18360     10 LADVVFKIQ-GTTVPAHRAVLVARCEVMAAMFNGNYAEAKSFL---VPIYgvsKDTFLSFLEYLYTDSCCPASILQAM-- 83

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  843 icNVLVVADQLLISRLKEICEVAIAEKL 870
Cdd:cd18360     84 --ALLICAEMYQVSRLQHICELYIITQL 109
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 756-862 3.77e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 50.60  E-value: 3.77e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  756 LKFNQKkcsyLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIk 835
Cdd:cd18259     26 LRSNPK----LSDVTL-LVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKDVDPAVMESLIDFAYTGK-LTI- 98

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  836 DSQNVE-FICNvlvvADQLLISRLKEIC 862
Cdd:cd18259     99 NQGNVEaLIRT----SNRLQFPTVRKVC 122
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 758-862 4.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 49.27  E-value: 4.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  758 FNQKKCSylcDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEassCSALEMP---IHSDILQIIVDYLYTDEAlai 834
Cdd:cd18314      1 YNDSEFS---DVVLCVGD-RKFFAHRIVLCARSPVFRSMLTGSMIE---SNLKEVTledVEPEIFETVLKYMYTGQV--- 70

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  835 kdSQNVEFICNVLVVADQLLISRLKEIC 862
Cdd:cd18314     71 --TLSEENVLDLLMLASKYQVPDLEKLC 96
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-874 5.08e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 50.22  E-value: 5.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIkDSQNVEficNVL 847
Cdd:cd18340     29 DCVLKIKE-KEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLEDVDPDVMGKILHYIYTSE-IEI-TEQNVQ---DIF 102

                           90       100
                   ....*....|....*....|....*..
gi 1201871476  848 VVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18340    103 AAANMFQIPSIFTVCVSFLQKRLCLSN 129
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 757-870 5.32e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 49.83  E-value: 5.32e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  757 KFNQKKCsyLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKD 836
Cdd:cd18253     11 EFRDSRL--FTDVII-CVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEINGILAEAMDCFLQYVYTGKVKITTE 87

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1201871476  837 sqNVEFIcnvLVVADQLLISRLKEICEVAIAEKL 870
Cdd:cd18253     88 --NVQYL---FETSSLFQISPLRDACAKFLEEQL 116
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-866 6.22e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 49.63  E-value: 6.22e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  767 CDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDE-----ALAIKDSQ--N 839
Cdd:cd18280     15 ADVTF-NVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIEDVEPPVFKALLHFIYKDElpddvEPAGSDSSslD 93

                           90       100
                   ....*....|....*....|....*..
gi 1201871476  840 VEFICNVLVVADQLLISRLKEICEVAI 866
Cdd:cd18280     94 TTMAQHLLAAADRYALERLRLLCESRL 120
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 754-868 7.68e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 49.58  E-value: 7.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  754 NKLKFNQKKCSYLCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEM-PIHSDILQIIVDYLYTDEAL 832
Cdd:cd18207     15 HNLNQQRKSGGRFCDVLLRVGE-ESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMhTISSKVFGDILDFAYTSRIV 93

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1201871476  833 AikdsqNVEFICNVLVVADQLLISRLKEICEVAIAE 868
Cdd:cd18207     94 V-----RLESFPELMTAAKFLLMRSVIDICQEVIKQ 124
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-874 8.10e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 49.45  E-value: 8.10e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSwIEASSCSALEM-PIHSDILQIIVDYLYTDEALAIKdsqnvEFICNV 846
Cdd:cd18279     20 DCCL-CVGGQEFQAHKAILAARSPVFSAMFEHE-MEESKKNRVEInDVDPEVFKEMMRFIYTGKAPNLD-----KMADDL 92

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  847 LVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18279     93 LAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 754-830 1.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 48.91  E-value: 1.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  754 NKLKFNQKkcsyLCDVTLKSSDG---KEFPCHKCVLCARLDYFHSMLSSSWIEassCSALEMPI---HSDILQIIVDYLY 827
Cdd:cd18248     13 NELRLSQQ----LCDVTLKVKYQdpkEEFMAHKVVLASSSPYFKAMFTSGLRE---CGMEVVPIegvHPCVMSRLIEFAY 85


                   ...
gi 1201871476  828 TDE 830
Cdd:cd18248     86 TAS 88
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 545-638 1.29e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 48.44  E-value: 1.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  545 SSFGEDFGKLLDETDemdsIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVS-SDSQLETPDVYRKDEDAvgCDlyviek 623
Cdd:cd18292      2 REFLQDIAQLYNNEE----LSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIELVEDPE--CA------ 69

                           90
                   ....*....|....*
gi 1201871476  624 vhpDLFAYLLQFIYT 638
Cdd:cd18292     70 ---AVFEKFLRYLYT 81
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 767-828 1.30e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 48.35  E-value: 1.30e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1201871476  767 CDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSswiEASSCSALEMPIH--SDILQIIVDYLYT 828
Cdd:cd18311     15 CDLTLQFRDNEQLKVHRLVLSACTDYFNVLEQT---CEIVDDTLIMPNElqADAVVPVINFMYT 75
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 765-874 1.83e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 48.64  E-value: 1.83e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  765 YLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEaSSCSALEMPIHSDI-LQIIVDYLYTDEAlaikdSQNVEFI 843
Cdd:cd18264     27 FLCDVVLEA-EGNEFPAHRSLLACSSDYFRALFKDYTQE-SKARVIHLPVVSAAgLQRVLDFIYTSWL-----SLSLDTL 99

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1201871476  844 CNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18264    100 EDTLEAASYLQVTEAIGLCSQYLINNLAPEN 130
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-874 2.11e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 48.08  E-value: 2.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  776 GKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEAlaikdsQNVEFIC-NVLVVADQLL 854
Cdd:cd18343     30 GQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKA------PNLDKMAdNLLAAADKYA 103

                           90       100
                   ....*....|....*....|
gi 1201871476  855 ISRLKEICEVAIAEKLTLKN 874
Cdd:cd18343    104 LERLKVMCEEALCNNLSVEN 123
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-875 3.02e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 48.03  E-value: 3.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  776 GKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIkdsQNVEFICNVLVVADQLLI 855
Cdd:cd18344     32 GHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHDLDPQVFKEMMGFIYTGKAPHL---HSHSMACDVLAAADKYGL 108

                           90       100
                   ....*....|....*....|
gi 1201871476  856 SRLKEICEVAIAEKLTLKNA 875
Cdd:cd18344    109 EGLKVLCEDALCRNLSVENA 128
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 3.03e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 47.90  E-value: 3.03e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDsqletPDVYRKdedavgcdlYVIEKVHPDLFAYLLQFIYT 638
Cdd:cd18224     28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTE-----LDVART---------YVVDFITPANFEKVLSFIYT 86
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
144-193 3.16e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 45.20  E-value: 3.16e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1201871476  144 EVYTWGNNINFTLGHGGQQSKHHPELVDLFPRNSVyiKQVVLCKFHSVFL 193
Cdd:pfam00415    3 RVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKV--VQVACGGDHTVAL 50
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-863 3.31e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 46.98  E-value: 3.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIKDSqNVEficN 845
Cdd:cd18234      1 LCDVILIAGD-RRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKDVDPDALWTLVQYCYTGR-LELKED-NVE---S 74

                           90
                   ....*....|....*...
gi 1201871476  846 VLVVADQLLISRLKEICE 863
Cdd:cd18234     75 LLATACLLQLSEVVEACC 92
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-862 3.60e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 48.06  E-value: 3.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSA-LEMPIHSDILQIIVDYLYTdeALAIKDSQNVEficNV 846
Cdd:cd18267     42 DVLLHAGN-RSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVnFHDSIHPEVLELLLDYAYS--SRVIINEENAE---SL 115

                           90
                   ....*....|....*.
gi 1201871476  847 LVVADQLLISRLKEIC 862
Cdd:cd18267    116 LEAGDMLEFQDIRDAC 131
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 754-841 4.84e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 47.31  E-value: 4.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  754 NKLKFNQKKCSYlCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEA-SSCSALEMPIHSDILQIIVDYLYTDEal 832
Cdd:cd18254     11 THLNTLRKQCMF-TDVTLWAGN-RSFPCHRAVLAACSRYFEAMFSNGLRESlDSTVNFHDSLHPEVLELLLDFAYSSR-- 86


                   ....*....
gi 1201871476  833 AIKDSQNVE 841
Cdd:cd18254     87 IIINEENAE 95
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 766-830 5.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 46.00  E-value: 5.40e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1201871476  766 LCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLssswIEASSCsalEMPI------HSDILQIIVDYLYTDE 830
Cdd:cd18315      1 LVDVTL-ACEGGSLKAHKLVLAAASPYFAALL----KETPPD---EHPViilpdvPYSELKALLDFIYTGE 63
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 758-863 6.21e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 46.51  E-value: 6.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  758 FNQkkcSYLCDVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEM---PIHSDILQIIVDYLYTDEAlai 834
Cdd:cd18292     12 YNN---EELSDIVLRV-GGKVFHAHRLILAKSSDVFRVMLSNDWWSESKQSEIELvedPECAAVFEKFLRYLYTGQI--- 84

                           90       100
                   ....*....|....*....|....*....
gi 1201871476  835 kdSQNVEFICNVLVVADQLLISRLKEICE 863
Cdd:cd18292     85 --SVNLETALPLLMLADKYNVTDLKQLCV 111
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
234-261 6.61e-06

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 43.95  E-value: 6.61e-06
                           10        20
                   ....*....|....*....|....*...
gi 1201871476  234 QIAAAKDHTVALTEDGCVYTFGLNTFHQ 261
Cdd:pfam13540    3 SVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-874 9.27e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 46.63  E-value: 9.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIKDsQNVEficNVL 847
Cdd:cd18269     29 DCVLKIGD-KEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLEDVDPDVMGMILKYLYTSE-IDLND-QNVQ---DIF 102

                           90       100
                   ....*....|....*....|....*..
gi 1201871476  848 VVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18269    103 ALASRFQIPSIFTVCVSYLQKRLSLSN 129
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 559-639 1.11e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 46.09  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  559 DEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSdsqletpdvyRKDEDAVgcdlyVI--EKVHPDLFAYLLQFI 636
Cdd:cd18295     14 LEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETK----------WKDKREI-----NLkhPLVNPDAFRALLQYL 78


                   ...
gi 1201871476  637 YTD 639
Cdd:cd18295     79 YTG 81
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 764-862 1.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 45.83  E-value: 1.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  764 SYLCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDSQNVefi 843
Cdd:cd18338     19 NLLCDVTIVAED-VEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQV--- 94

                           90
                   ....*....|....*....
gi 1201871476  844 cnVLVVADQLLISRLKEIC 862
Cdd:cd18338     95 --LLPAAGLLQLQDVKKTC 111
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-638 1.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 45.60  E-value: 1.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  549 EDFGKLLDETdemdSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFvssDSQLETPDVYRKDedavgcdlyvIEKVHPDL 628
Cdd:cd18279      7 EDLGNLWENS----RFTDCCLCVGGQEFQAHKAILAARSPVFSAMF---EHEMEESKKNRVE----------INDVDPEV 69

                           90
                   ....*....|
gi 1201871476  629 FAYLLQFIYT 638
Cdd:cd18279     70 FKEMMRFIYT 79
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 776-862 1.72e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 45.32  E-value: 1.72e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  776 GKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEaLAIkdsqNVEFICNVLVVADQ--- 852
Cdd:cd18295     28 GESFPAHRCILSARSPYFAEMFETKWKDKREINLKHPLVNPDAFRALLQYLYTGR-LEI----HVDDVEDCKRLAKQcrl 102

                           90
                   ....*....|.
gi 1201871476  853 -LLISRLKEIC 862
Cdd:cd18295    103 eELIEELEAKC 113
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 549-638 2.21e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 45.22  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  549 EDFGKLLDETdemdSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFvssDSQLETPDVYRKDedavgcdlyvIEKVHPDL 628
Cdd:cd18345      7 DDLGLLFERS----AFSDVTLCVGGREFQAHKAILAARSPVFNAMF---EHEMEERKQNRVE----------ITDVDHEV 69

                           90
                   ....*....|
gi 1201871476  629 FAYLLQFIYT 638
Cdd:cd18345     70 MREMLRFIYT 79
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 759-843 2.28e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 45.18  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  759 NQKKCSYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEassCSALEMPIHsDI----LQIIVDYLYTDEaLAI 834
Cdd:cd18276     14 RMKELAELTDVVL-VAEGEKFPCHRLVLAAFSPYFKAMFTCGLME---CSQREVVLH-DItaesVSIILNYMYSSD-LHL 87


                   ....*....
gi 1201871476  835 KDSqNVEFI 843
Cdd:cd18276     88 TNS-NVQGV 95
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-867 2.53e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 44.96  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLKSSdGKEFPCHKCVLCaRLDYFHSMLSSSWIEA-SSCSALEMP---IHSDILQIIVDYLYTDEALaIKDSQNVefi 843
Cdd:cd18305     17 DITICAL-GREWKLHKIYLC-QSGYFASMFSGSWKESkETVINLEIPddnITVEALNVVFGSLYRDEIE-IKPSRVV--- 90

                           90       100
                   ....*....|....*....|....*
gi 1201871476  844 cNVLVVADQLLISRLKEIC-EVAIA 867
Cdd:cd18305     91 -SILAAATLLQLDGLIQQCsEVMKE 114
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-875 2.57e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 45.09  E-value: 2.57e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  776 GKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDSQNveficNVLVVADQLLI 855
Cdd:cd18342     31 GQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMAD-----DLLAAADKYAL 105

                           90       100
                   ....*....|....*....|
gi 1201871476  856 SRLKEICEVAIAEKLTLKNA 875
Cdd:cd18342    106 ERLKVMCEDALCSNLSVENA 125
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 537-645 2.58e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 44.92  E-value: 2.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  537 YEIPSVSLSSfgEDFGKLLDETDemdsIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVYRKDEDAVGc 616
Cdd:cd18287      1 GEIDHVHFLS--EDIGALFLNEE----YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDTNAEA- 73

                           90       100
                   ....*....|....*....|....*....
gi 1201871476  617 dlyviekvhpdlFAYLLQFIYTDTCDLLT 645
Cdd:cd18287     74 ------------FKALLKYIYTGRLTLTD 90
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-828 2.63e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 44.92  E-value: 2.63e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1201871476  768 DVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEaSSCSALEMP-IHSDILQIIVDYLYT 828
Cdd:cd18287     24 DVTF-VVEEKRFPAHRVILAARSEYFRALLYGGMRE-SQQSEIELKdTNAEAFKALLKYIYT 83
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-866 2.64e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 44.55  E-value: 2.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  775 DGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMPIHS-DILQIIVDYLYTDEAlaikdSQNVEFICNVLVVADQL 853
Cdd:cd18298     20 DGKYIYVHKAILKIRCEYFRSMFQSHWNEDDK-NVIEIDQYSyPVYYAFLRYLYTDQV-----DLPPEDAIGLLDLANSY 93

                           90
                   ....*....|...
gi 1201871476  854 LISRLKEICEVAI 866
Cdd:cd18298     94 CEERLKKLCEDII 106
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 2.76e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 44.79  E-value: 2.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVssdsqletpdvyrkDEDAVGCDLYVIEKVHPDLFAYLLQ 634
Cdd:cd18212     14 FEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFA--------------DEGEVGQSIYMLEGMVAETFGALLE 79


                   ....
gi 1201871476  635 FIYT 638
Cdd:cd18212     80 FIYT 83
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-871 3.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 44.96  E-value: 3.49e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEAsscSALEMPIH---SDILQIIVDYLYTDEAL---- 832
Cdd:cd18261     22 QRNDGILCDITLVAEEQK-FHAHKAVLAACSDYFRAMFSLCMVES---EADEVNLHgvtSLGLKQALDFAYTGQILlepg 97

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1201871476  833 AIKDsqnveficnVLVVADQLLISRLKEICEVAIAEKLT 871
Cdd:cd18261     98 VIQD---------VLAAGSHLQLLELLSLCSHYLIQELN 127
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-649 5.24e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 44.10  E-value: 5.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFvSSDSQLETPDVYRkdedavgcdlyvIEKVHPDLFAYLLQFIYTDTCDLLT 645
Cdd:cd18328     27 DVVLIVQDQEYRTHRSVLAACSKYFKKLF-TAGTLADQPYVYE------------IDFVTPEALSAILEFAYTSTLTITT 93


                   ....
gi 1201871476  646 HGYK 649
Cdd:cd18328     94 SNVK 97
Ank_4 pfam13637
Ankyrin repeats (many copies);
52-107 5.69e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.88  E-value: 5.69e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1201871476   52 GRNVLHLASSCGKKGVLDWLAEtKGVDLLAKDkESGWTALHRSIFYGYIDCVLSLL 107
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLE-KGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 768-879 6.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 44.50  E-value: 6.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  768 DVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEA-LAIKDSQnveficNV 846
Cdd:cd18272     34 DVTI-SVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVkLRVEELQ------ET 106

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1201871476  847 LVVADQLLISRLKEICEVAIAEKLTLKNAAELL 879
Cdd:cd18272    107 YEVADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 553-643 7.43e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 44.07  E-value: 7.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  553 KLLDEtdemDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYL 632
Cdd:cd18341     20 ELLDE----NKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEV-------------VLDNVDPNIMDMI 82

                           90
                   ....*....|.
gi 1201871476  633 LQFIYTDTCDL 643
Cdd:cd18341     83 LKYLYSAEIDL 93
PHA02713 PHA02713
hypothetical protein; Provisional
 766-868 8.35e-05

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 46.93  E-value: 8.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPI-HSDILQIIVDYLYTDEAlaikDSQNVefiC 844
Cdd:PHA02713    25 LCDVIITIGDGEEIKAHKTILAAGSKYFRTLFTTPMIIRDLVTRVNLQMfDKDAVKNIVQYLYNRHI----SSMNV---I 97

                           90       100
                   ....*....|....*....|....
gi 1201871476  845 NVLVVADQLLISRLKEICEVAIAE 868
Cdd:PHA02713    98 DVLKCADYLLIDDLVTDCESYIKD 121
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-643 9.07e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 43.20  E-value: 9.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyviEKVHPDLFAYLLQ 634
Cdd:cd18217      9 LNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQ---------------SQVSADGFQKLLE 73


                   ....*....
gi 1201871476  635 FIYTDTCDL 643
Cdd:cd18217     74 FIYTGNLNL 82
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 765-830 1.22e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 42.32  E-value: 1.22e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1201871476  765 YLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEAS------SCSALEMPIHSDILQiivdYLYTDE 830
Cdd:cd18283      1 YCTDVDL-VFQGTCFPVHRAILSARCPFFRDLLSSSPGYGAeipvdlPTAGIDVPMFSALLR----YLYTGE 67
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 750-862 1.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 43.11  E-value: 1.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  750 KKNGNKLKFNQkkcsyLCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTD 829
Cdd:cd18336      8 RKMENYLQHKQ-----LCDVLLIAGNLK-IPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKMEGVDPDALKALVHYAYTG 81

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1201871476  830 eALAIKDsqnvEFICNVLVVADQLLISRLKEIC 862
Cdd:cd18336     82 -VLELKE----DTIESLLAAACLLQLSQVIDVC 109
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 538-638 1.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 43.07  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  538 EIPSVSLSsfgEDFGKLLDETdemdSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFvssDSQLETPDVYRKDedavgcd 617
Cdd:cd18343      2 KVPECRLA---EDLGNLWENS----RFTDCSLFVGGQEFKAHKSILAARSPVFNAMF---EHEMEESKKNRVE------- 64

                           90       100
                   ....*....|....*....|.
gi 1201871476  618 lyvIEKVHPDLFAYLLQFIYT 638
Cdd:cd18343     65 ---INDVDPEVFKEMMRFIYT 82
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 1.45e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 42.67  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLetpdVYRKDEDavgcdlyviekVHPDLFAYLLQ 634
Cdd:cd18193     12 LNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSEC----VRLKPTD-----------IQPDIFSYLLH 76


                   ....
gi 1201871476  635 FIYT 638
Cdd:cd18193     77 LMYT 80
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 751-871 2.04e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 42.64  E-value: 2.04e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  751 KNGNKLKFNQKKCSYlCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDE 830
Cdd:cd18358      6 RKANRIKECLSKGTF-SDVTFKLDDGT-INAHKPLLICSCEWMAAMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1201871476  831 ALAIKDSQNVEFIcnvlVVADQLLISRLKEICEVAIAEKLT 871
Cdd:cd18358     84 LSPTADLDPLELI----ALANRFCLPHLVALTEQHAVQELT 120
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 54-124 2.23e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.63  E-value: 2.23e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201871476   54 NVLHLASScGKKGVLDWLAETKgvdllaKDKE----SGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSAL 124
Cdd:PLN03192   528 NLLTVAST-GNAALLEELLKAK------LDPDigdsKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTAL 595
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 2.32e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 41.97  E-value: 2.32e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFvssdsqleTPDVYRKDEDAVgcdlyVIEKVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18234      3 DVILIAGDRRIPAHRLVLSAVSDYFAAMF--------TNDVREATEEEI-----KLKDVDPDALWTLVQYCYTGRLEL 67
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-874 2.35e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 42.48  E-value: 2.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  766 LCDVTLKSSDGKE-FPCHKCVLCARLDYFHSMLSSSWIEAsscSALEMPIH--SDI-LQIIVDYLYTDealaiKDSQNVE 841
Cdd:cd18239     23 LCDVTLVPGDGDEtFPVHRAMMASASDYFKAMFTGGMKEQ---ELMCIKLHgvSKIgLKNIIDFIYTA-----KLSLNMD 94

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1201871476  842 FICNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18239     95 NLQDTLEAASFLQILPVLDFCKVLLISGVTLEN 127
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-640 2.61e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 42.14  E-value: 2.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedAVGCDLYVIEKVHPDLFAYLLQ 634
Cdd:cd18327     16 LNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGA------GGGQDVCELDFVGPEALGALLE 89


                   ....*.
gi 1201871476  635 FIYTDT 640
Cdd:cd18327     90 FAYTAT 95
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 2.82e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 42.25  E-value: 2.82e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFvssdsqleTPDVYRKDEDAVGcdlyvIEKVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18244     32 DVTLVIEDHQFQAHKALLATQSDYFRIMF--------TADMRERDQDKIH-----LKGLTATGFSHVLQFMYYGTIEL 96
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-874 3.05e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 42.34  E-value: 3.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  767 CDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEmpihsdiLQIIVDYLYTDEAlaikdSQNVEFICNV 846
Cdd:cd18243     33 CDVTL-TAQGQQFHCHKAVLASCSQYFRSLFSINNLVLQGCSSIG-------LRLVLEYLYTANV-----TLSLDTVEEV 99

                           90       100
                   ....*....|....*....|....*...
gi 1201871476  847 LVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18243    100 LSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-640 3.29e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 41.78  E-value: 3.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSqletpdvyrkdedAVGCDLYVIEKVHPDLFAYLLQ 634
Cdd:cd18198     16 LNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAV-------------VDQQNVYEIDFVSPEALTALLE 82


                   ....*.
gi 1201871476  635 FIYTDT 640
Cdd:cd18198     83 FAYTAT 88
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 4.06e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 41.54  E-value: 4.06e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLEtpdvyrkdedavgcdlyvIEKVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18303     20 DITIKLADKSIPAHKFVLAARSEKWSNENLASTNELD------------------LSDISYEVVLALLRWLYTDELDL 79
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 744-877 5.00e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 41.50  E-value: 5.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  744 KINVVNKKNGNKLK---FNQKKCSylcDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMpIHSDILQ 820
Cdd:cd18351      2 KLTEIKRKQTSRLDphfLNNKEMS---DVTF-LVEGRPFYAHKVLLFTASPRFKALLSNKPSAENTCIEISY-VKYHIFQ 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1201871476  821 IIVDYLYT--DEALAIKDSQNVEficnVLVVADQLLISRLKEICEVAIAEKLTLKNAAE 877
Cdd:cd18351     77 LVMQYLYCggTESLLIKNNEIME----LLSAAKFFQLEALQRHCEIICAKSINTENCVD 131
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 768-829 5.77e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 40.35  E-value: 5.77e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476  768 DVTLKSsDGKEFPCHKCVLCARLDYFHSMLSSSwiEASSCSALEMP------IHSDILQIIVDYLYTD 829
Cdd:cd18301     20 DVVFQV-GGKTFPAHKFILASRSDYFRKLFLSS--LLTSEDAVGCDvvhiekVPPEIFEQLLQFIYTD 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
43-124 7.84e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 43.02  E-value: 7.84e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476   43 NAATIKDAFGRNVLHLASSCGKKGVLDWLAETKGVDLLAKDKEsGWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLS 122
Cdd:COG0666     44 LLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGET 122


                   ..
gi 1201871476  123 AL 124
Cdd:COG0666    123 PL 124
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 871-922 8.81e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 38.80  E-value: 8.81e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1201871476  871 TLKNAAELLEFSATYNAEQLKLSCLQFIGLNMAALLETRTLDVLSDEVVKDL 922
Cdd:cd14733      1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLEL 52
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 572-643 9.12e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 40.07  E-value: 9.12e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201871476  572 GTRTYAVHKYILAVRSDFFKKLF----VSSDSQLETPDvyrkdedavgcdlyviekVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18282     19 GTQRIPAHKYVLATGSSVFYAMFygglAENKNEIEIPD------------------VEPAAFLNLLRYLYCDEIDL 76
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 751-874 9.19e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 40.98  E-value: 9.19e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  751 KNGNKLKFNQKKcsyLCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDE 830
Cdd:cd18341     15 QDGLKELLDENK---FVDCTLKAGD-KSLPCHRLILAACSPYFREYFLSEESEEKKKEVVLDNVDPNIMDMILKYLYSAE 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1201871476  831 aLAIKDSqNVEficNVLVVADQLLISRLKEICEVAIAEKLTLKN 874
Cdd:cd18341     91 -IDLNDG-NVQ---DIFALASRFQIPSVFTVCVTYLQKRLSPAN 129
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 752-830 9.23e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 40.17  E-value: 9.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  752 NGNKLKF---NQKKCSYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSwiEASSCSALEMPIHSdILQIIVDYLYT 828
Cdd:cd18226      5 NKNLLKYlndDRQKQSSFCDLVI-TVEGKEFSAHKVVVAVGSSYFHACLSKN--PNTDAVTLDHVSYS-VFQHLLEFLYT 80


                   ..
gi 1201871476  829 DE 830
Cdd:cd18226     81 SE 82
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 543-638 9.37e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 41.14  E-value: 9.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  543 SLSSfgeDFGKLLDETDEMDSihDVTLQI-GTRTYAVHKYILAVRSDFFKKLFVSS--DSQLETPDVYRKDEDAVGcdly 619
Cdd:cd18310      2 KLSS---DLENLLDSPDLFYS--DAEIIVeGGRPVPVHRCILAARSPFFRDIFASAkaEGANTKPKLELRELIPGG---- 72

                           90
                   ....*....|....*....
gi 1201871476  620 vieKVHPDLFAYLLQFIYT 638
Cdd:cd18310     73 ---IVGYDAFMLVLSYLYS 88
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-862 1.22e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 40.30  E-value: 1.22e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLCDVTLkSSDGKEFPCHKCVLCARLDYFHsMLSSSWIEASSCSALEMP-IHSDILQIIVDYLYTdEALAIKDSQ 838
Cdd:cd18326     19 QRTQGLLCDVVI-LVEGREFPTHRSVLAACSQYFK-KLFTSGAVVDQQNVYEIDfVSAEALTALLDFAYT-ATLTVSTSN 95

                           90       100
                   ....*....|....*....|....
gi 1201871476  839 nvefICNVLVVADQLLISRLKEIC 862
Cdd:cd18326     96 ----VGDILSAARLLEIPAVSHVC 115
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 766-840 1.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 40.16  E-value: 1.24e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201871476  766 LCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMP-IHSDILQIIVDYLYTDEaLAIKDSQNV 840
Cdd:cd18223     18 LCDVTIVVEDTK-FKAHKNVLAASSLYFKNAFSSQEIWISS-HVLELPdLKAEVFAEILNFIYSSK-VVVKRQETV 90
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 767-799 1.28e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 40.06  E-value: 1.28e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1201871476  767 CDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSS 799
Cdd:cd18309     21 CDITL-LLDGHPIPAHKAILAARCSYFEAMFRS 52
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-862 1.32e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 40.02  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  767 CDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMpIHSDILQIIVDYLYTDEALAIKDSqnvefiCNV 846
Cdd:cd18204     19 CDIAIVVEDVK-FRAHRCVLAACSTYFKKLFKKLEVDSSSVIEIDF-LRSDIFEEVLNYMYTAKISVKKED------VNL 90

                           90
                   ....*....|....*..
gi 1201871476  847 LVVADQLL-ISRLKEIC 862
Cdd:cd18204     91 MMSSGQILgIRFLDKLC 107
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 555-638 1.34e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 39.98  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  555 LDETDEMDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFvssdsqletpdvyrkdEDAVGCDLYVIEKVHPDLFAYLLQ 634
Cdd:cd18221      9 LNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFF----------------QDFTQEPLVEIEGVSNMAFRHLIE 72


                   ....
gi 1201871476  635 FIYT 638
Cdd:cd18221     73 FTYT 76
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-638 1.36e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 40.06  E-value: 1.36e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1201871476  566 DVTLQIG----TRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYLLQFIYT 638
Cdd:cd18248     23 DVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGMEVV-------------PIEGVHPCVMSRLIEFAYT 86
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 1.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 39.86  E-value: 1.49e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSqlETPDVYRKDEdavgCDlyviekvhPDLFAYLLQFIYTDT 640
Cdd:cd18209     20 DVLLIVGDQKFRAHKNVLAASSEYFQSLFTEKEN--ESQSVFQLDF----CE--------PDAFENVLNYIYSSS 80
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 554-643 1.55e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 40.08  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  554 LLDEtdemDSIHDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYLL 633
Cdd:cd18269     21 LLDE----NKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEV-------------VLEDVDPDVMGMIL 83

                           90
                   ....*....|
gi 1201871476  634 QFIYTDTCDL 643
Cdd:cd18269     84 KYLYTSEIDL 93
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 776-878 1.77e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 39.82  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  776 GKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDEALAIKDsqNVEFIcnvLVVADQLLI 855
Cdd:cd18271     33 DETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDD--NVEMF---FQMSSFLQV 107

                           90       100
                   ....*....|....*....|...
gi 1201871476  856 SRLKEICEVAIAEKLTLKNAAEL 878
Cdd:cd18271    108 SLLSKACSDFLIKSIDLTNCLQL 130
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-640 2.28e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 39.35  E-value: 2.28e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLFAYLLQFIYTDT 640
Cdd:cd18242     23 DVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEV-------------ELQGLTASTMEILLDFVYTET 84
Ank_4 pfam13637
Ankyrin repeats (many copies);
87-125 2.35e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.25  E-value: 2.35e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1201871476   87 GWTALHRSIFYGYIDCVLSLLKHGVSLYIQDKEGLSALD 125
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALH 39
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 550-645 2.38e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 39.18  E-value: 2.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  550 DFGKLLDETdEMDsihDVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETPDVyrkdedavgcdlyVIEKVHPDLF 629
Cdd:cd18297      2 IDPHYVNNP-EMS---DVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVI-------------EIPDIRYDIF 64

                           90
                   ....*....|....*.
gi 1201871476  630 AYLLQFIYTDTCDLLT 645
Cdd:cd18297     65 QLMMQYLYTGGVESLD 80
BACK_AtBPM-like cd14736
BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The ...
 868-917 2.44e-03

BACK (BTB and C-terminal Kelch) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins. BPM protein, also termed protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350516  Cd Length: 62  Bit Score: 37.71  E-value: 2.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1201871476  868 EKLTLKNAAELLEFSATYNAEQLKLSCLQFIGLNMAALLETRTLDVLSDE 917
Cdd:cd14736      2 EGVDVNTVATTLALAEQHHASQLKAVCLKFVARNLAAVMQTDGFEYLKES 51
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 565-638 2.87e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 39.17  E-value: 2.87e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1201871476  565 HDVTLQIGTRTYAVHKYILAVRSdffKKLFvssdsqletpDVYRKDEDAVGCDLYVIEKVHPDLFAYLLQFIYT 638
Cdd:cd18306     19 CDVILQVGGHEIPAHRAVLACAS---PYLF----------ELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYT 79
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 572-643 3.16e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 38.81  E-value: 3.16e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201871476  572 GTRTYAVHKYILAVRSDFFKKLF----VSSDSQLETPDvyrkdedavgcdlyviekVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18349     20 ASQRVPAHKYVLAVGSSVFYAMFygdlAEVKSEIHIPD------------------VEPAAFLILLKYMYSDEIDL 77
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-641 3.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 39.11  E-value: 3.17e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQletpdvyrkdedavgCDLYVIEKVHPDLFAYLLQFIYTDTC 641
Cdd:cd18213     23 DCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSE---------------CIKIQPTDIQPDIFSYLLHIMYTGKG 83
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-835 3.30e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 38.66  E-value: 3.30e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1201871476  760 QKKCSYLCDVTLKSSDGKeFPCHKCVLCARLDYFHSMLSSswieASSCSALEMpIHSDILQIIVDYLYTDEALAIK 835
Cdd:cd18219     15 QRGHGLFCDVTVIVEDRK-FRAHKNILSASSTYFHQLFSV----AGQVVELNF-IRADIFAEILNYIYSSKIVRVR 84
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 566-651 3.44e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 38.08  E-value: 3.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQ-------LETPDVyrkdedavgcdlyvieKVHpdLFAYLLQFIYT 638
Cdd:cd18283      4 DVDLVFQGTCFPVHRAILSARCPFFRDLLSSSPGYgaeipvdLPTAGI----------------DVP--MFSALLRYLYT 65

                           90
                   ....*....|...
gi 1201871476  639 DtcDLLTHGYKPK 651
Cdd:cd18283     66 G--EFGSEDSRSQ 76
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 761-862 3.61e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 38.97  E-value: 3.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  761 KKCSYLCDVTLKSSDGKEFpCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTdeALAIKDSQNV 840
Cdd:cd18249     18 RKHRELCDVVLVVGAKKIY-AHRVILSACSPYFRAMFTGELAESRQTEVTIRDIDERAMELLIDFAYT--SQITVEEGNV 94

                           90       100
                   ....*....|....*....|..
gi 1201871476  841 EficNVLVVADQLLISRLKEIC 862
Cdd:cd18249     95 Q---TLLPAACLLQLAEIQEVC 113
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 760-862 4.31e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 39.10  E-value: 4.31e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  760 QKKCSYLCDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASScSALEMPIHSDI-LQIIVDYLYTDEaLAIkDSQ 838
Cdd:cd18266     19 QRQRGLFCDVVL-VADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQ-KEVELVGASYIgLKAVIDFLYSSE-LPL-DGG 94

                           90       100
                   ....*....|....*....|....
gi 1201871476  839 NVEFicnVLVVADQLLISRLKEIC 862
Cdd:cd18266     95 NIDY---VLETAHLLQIWKVVDFC 115
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 871-919 4.88e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 37.29  E-value: 4.88e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1201871476  871 TLKNAAELLEFSATYNAEQLKLSCLQFIGLNMAALLETRTLDVLSDEVV 919
Cdd:cd18494      1 SVETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEAL 49
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 775-866 5.40e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 38.39  E-value: 5.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  775 DGKEFPCHKCVLCARLDYFHSMLSSSWIEAS----SCSALEMPIHSDILQiivdYLYTDEA-LAIKDSqnvefiCNVLVV 849
Cdd:cd18353     28 DGKYIHVHKAVLKIRCEHFRTMFQSHWNEDMkeviEIDQFSYPVYRAFLE----YLYTDSVdLPPEDA------IGLLDL 97

                           90
                   ....*....|....*..
gi 1201871476  850 ADQLLISRLKEICEVAI 866
Cdd:cd18353     98 ATSYCENRLKKLCQHII 114
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 767-862 5.89e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 37.48  E-value: 5.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  767 CDVTLkSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEAS---SCSALEMPIHSDILQIIVDYLYTDEaLAIKDsQNVEfi 843
Cdd:cd18307      2 CDVVI-SVDNHSFAAHRNVLAAVSPFVKSLISSNDMKATdelSITIDCDYLSPETVEQLLDYFYTGK-IVISE-KNVE-- 76

                           90
                   ....*....|....*....
gi 1201871476  844 cNVLVVADQLLISRLKEIC 862
Cdd:cd18307     77 -DLLKGAKYFNIPRLKDHC 94
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 549-638 6.42e-03

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 37.58  E-value: 6.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  549 EDFGKLLDetDEMDSihDVT--LQIGTRTYAvHKYILAVRSDFFKKLFvssdsqletpdvyrkdedavgCDLYVIEK--- 623
Cdd:cd18299      1 EDLRNLLH--SPSCA--DVVfiLQGGVRIFA-HRIVLAAASSVFADLF---------------------LMMTVVTLdsd 54

                           90
                   ....*....|....*
gi 1201871476  624 VHPDLFAYLLQFIYT 638
Cdd:cd18299     55 ITPEAFRRVLEFLYT 69
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 566-643 6.49e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 37.70  E-value: 6.49e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1201871476  566 DVTLQIGTRTYAVHKYILAVRSDFFKKLFVSSDSQLETpDVYRKDedavgcdlyvIEKVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd18245     16 DATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDG-STYKIE----------LEGISVEVMEEILDYIYTGQIKL 82
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 762-862 7.11e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 38.10  E-value: 7.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1201871476  762 KCSYLCDVTLKSSDgKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSALEMPIHSDILQIIVDYLYTDeALAIKDSqNVE 841
Cdd:cd18335     15 KQQQLCDVILIAGN-RKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKMEGIDPNALWDLVQFAYTG-CLELKED-TIE 91

                           90       100
                   ....*....|....*....|.
gi 1201871476  842 ficNVLVVADQLLISRLKEIC 862
Cdd:cd18335     92 ---NLLAAACLLQLSQVVEVC 109
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 768-828 8.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 38.44  E-value: 8.35e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1201871476  768 DVTLKSSDGKEFPCHKCVLCARLDYFHSMLSSSWIEASSCSA-LEMP-------IHSDILQIIVDYLYT 828
Cdd:cd18310     20 DAEIIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGANTKPkLELRelipggiVGYDAFMLVLSYLYS 88
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 567-643 8.74e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 36.49  E-value: 8.74e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1201871476  567 VTLQIGTRTYAVHKYILAVRSDFFKKLFVSSdsqletpdvYRKDEDAVgcdlYVIEKVHPDLFAYLLQFIYTDTCDL 643
Cdd:cd01165      1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGG---------FRESGQAE----INLRDISPEDFRALLEFLYGGKRDL 64
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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