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Conserved domains on  [gi|1191866837|ref|XP_020942675|]
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zinc finger protein 169 isoform X7 [Sus scrofa]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-529 2.35e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 163 STKSSLFSLQKH---HMCPECGRSFCQRSDLIKHQRTHTGEKPYSCRECGRG--FGRKSSLTIHQRKHSGEKPYmcRECG 237
Cdd:COG5048    19 TPKSTLKSLSNAprpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSD--LNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 238 QHFRYTSSLTNHKRIHSG-ERPFVCQECGRGF----RQKIALILHQRTHLEEKPfvCPECGRGFC--------------- 297
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSsNSNDNNLLSSHSLppssRDPQLPDLLSISNLRNNP--LPGNNSSSVntpqsnslhpplpan 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 298 -------------------------------QKASLLQHRSSHSGERPFL----CLECGRGFRQQSLLISHQVTHSGEKP 342
Cdd:COG5048   175 slskdpssnlsllissnvstsipsssensplSSSYSIPSSSSDQNLENSSsslpLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 343 YVCAECGHSFRQKVTLIRHQRTHTGE-------KPYLCSECGRGFSQKVSLMGHQRT--HTGE--KPYVCPE--CGRGFG 409
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 410 QKVTLIRHQRTHTGEKPYLCPECGHTFGFKSLLT--RHQKT--HSGEKADVYRVCEQRLSQKNLTSD--------QRTWS 477
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNnePPQSLqqYKDLKNDKKSETLSNSCIRNFKRDsnlslhiiTHLSF 414

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191866837 478 GEKPCVCDECGRGFGFKSALIRHQRTHSGEKPYICRECGRGFSQKSHLHRHR 529
Cdd:COG5048   415 RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-529 2.35e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 163 STKSSLFSLQKH---HMCPECGRSFCQRSDLIKHQRTHTGEKPYSCRECGRG--FGRKSSLTIHQRKHSGEKPYmcRECG 237
Cdd:COG5048    19 TPKSTLKSLSNAprpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSD--LNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 238 QHFRYTSSLTNHKRIHSG-ERPFVCQECGRGF----RQKIALILHQRTHLEEKPfvCPECGRGFC--------------- 297
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSsNSNDNNLLSSHSLppssRDPQLPDLLSISNLRNNP--LPGNNSSSVntpqsnslhpplpan 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 298 -------------------------------QKASLLQHRSSHSGERPFL----CLECGRGFRQQSLLISHQVTHSGEKP 342
Cdd:COG5048   175 slskdpssnlsllissnvstsipsssensplSSSYSIPSSSSDQNLENSSsslpLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 343 YVCAECGHSFRQKVTLIRHQRTHTGE-------KPYLCSECGRGFSQKVSLMGHQRT--HTGE--KPYVCPE--CGRGFG 409
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 410 QKVTLIRHQRTHTGEKPYLCPECGHTFGFKSLLT--RHQKT--HSGEKADVYRVCEQRLSQKNLTSD--------QRTWS 477
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNnePPQSLqqYKDLKNDKKSETLSNSCIRNFKRDsnlslhiiTHLSF 414

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191866837 478 GEKPCVCDECGRGFGFKSALIRHQRTHSGEKPYICRECGRGFSQKSHLHRHR 529
Cdd:COG5048   415 RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-436 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|...
gi 1191866837 414 LIRHQRTHTGEKPYLCPECGHTF 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 180-221 5.36e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191866837 180 CGRSFCQRSDLIKHQRTHTgekpYSCRECGRGFGRKSSLTIH 221
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-529 2.35e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.35e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 163 STKSSLFSLQKH---HMCPECGRSFCQRSDLIKHQRTHTGEKPYSCRECGRG--FGRKSSLTIHQRKHSGEKPYmcRECG 237
Cdd:COG5048    19 TPKSTLKSLSNAprpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSD--LNSK 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 238 QHFRYTSSLTNHKRIHSG-ERPFVCQECGRGF----RQKIALILHQRTHLEEKPfvCPECGRGFC--------------- 297
Cdd:COG5048    97 SLPLSNSKASSSSLSSSSsNSNDNNLLSSHSLppssRDPQLPDLLSISNLRNNP--LPGNNSSSVntpqsnslhpplpan 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 298 -------------------------------QKASLLQHRSSHSGERPFL----CLECGRGFRQQSLLISHQVTHSGEKP 342
Cdd:COG5048   175 slskdpssnlsllissnvstsipsssensplSSSYSIPSSSSDQNLENSSsslpLTTNSQLSPKSLLSQSPSSLSSSDSS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 343 YVCAECGHSFRQKVTLIRHQRTHTGE-------KPYLCSECGRGFSQKVSLMGHQRT--HTGE--KPYVCPE--CGRGFG 409
Cdd:COG5048   255 SSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFS 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 410 QKVTLIRHQRTHTGEKPYLCPECGHTFGFKSLLT--RHQKT--HSGEKADVYRVCEQRLSQKNLTSD--------QRTWS 477
Cdd:COG5048   335 RNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNnePPQSLqqYKDLKNDKKSETLSNSCIRNFKRDsnlslhiiTHLSF 414

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1191866837 478 GEKPCVCDECGRGFGFKSALIRHQRTHSGEKPYICRECGRGFSQKSHLHRHR 529
Cdd:COG5048   415 RPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
257-544 3.75e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 3.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 257 RPFVCQECGRGFRQKIALILHQRTHLEEKPFVCPECGRG--FCQKASLLQHRSSHSGERPFLCleCGRGFRQQSLLISHQ 334
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 335 VTHSGEKP-YVCAECGHSFRQKvtlIRHQRTHTGEKPY--LCSECGRGFSQKVSLMGHQRTHtGEKPYVCPeCGRGFGQK 411
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPS---SRDPQLPDLLSISnlRNNPLPGNNSSSVNTPQSNSLH-PPLPANSL-SKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191866837 412 VTLIRHQRTHTGEKPYLCPECGHTFGFKSLLTRHQKTHSGEKADVYrvCEQRLSQKNLTSDQR--TWSGEKPCVCDECGR 489
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLT--TNSQLSPKSLLSQSPssLSSSDSSSSASESPR 262

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191866837 490 GFGFKSALIRHQRTHSGE-------KPYICRECGRGFSQKSHLHRHRRTK--SGHHLLPQELFS 544
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSVnhSGESLKPFSCPY 326
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-436 1.05e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.05e-03
                          10        20
                  ....*....|....*....|...
gi 1191866837 414 LIRHQRTHTGEKPYLCPECGHTF 436
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
358-382 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*
gi 1191866837 358 LIRHQRTHTGEKPYLCSECGRGFSQ 382
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 175-197 1.87e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|...
gi 1191866837 175 HMCPECGRSFCQRSDLIKHQRTH 197
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
385-408 2.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.59e-03
                          10        20
                  ....*....|....*....|....
gi 1191866837 385 SLMGHQRTHTGEKPYVCPECGRGF 408
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 180-221 5.36e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 5.36e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1191866837 180 CGRSFCQRSDLIKHQRTHTgekpYSCRECGRGFGRKSSLTIH 221
Cdd:cd20908     7 CDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
189-212 7.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.21e-03
                          10        20
                  ....*....|....*....|....
gi 1191866837 189 DLIKHQRTHTGEKPYSCRECGRGF 212
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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