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Conserved domains on  [gi|1190990303|ref|XP_020876336|]
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3-isopropylmalate dehydrogenase 3, chloroplastic isoform X1 [Arabidopsis lyrata subsp. lyrata]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10010765)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 1-409 0e+00

3-isopropylmalate dehydrogenase


:

Pssm-ID: 215188  Cd Length: 409  Bit Score: 792.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303   1 MAAFLQTNIRLNSIKIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKIVLQKAGSLEGLEF 80
Cdd:PLN02329    1 MAAFLQTNIRLNSIKIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  81 DFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160
Cdd:PLN02329   81 DFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIKINENGEEVGISTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240
Cdd:PLN02329  161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320
Cdd:PLN02329  241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGDEVLKS 400
Cdd:PLN02329  321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400


                  ....*....
gi 1190990303 401 VESKVPATV 409
Cdd:PLN02329  401 VDSKVPATV 409
 
Name Accession Description Interval E-value
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 1-409 0e+00

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 792.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303   1 MAAFLQTNIRLNSIKIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKIVLQKAGSLEGLEF 80
Cdd:PLN02329    1 MAAFLQTNIRLNSIKIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  81 DFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160
Cdd:PLN02329   81 DFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIKINENGEEVGISTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240
Cdd:PLN02329  161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320
Cdd:PLN02329  241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGDEVLKS 400
Cdd:PLN02329  321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400


                  ....*....
gi 1190990303 401 VESKVPATV 409
Cdd:PLN02329  401 VDSKVPATV 409
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 46-399 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 559.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  46 RYNIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDK 125
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 126 nekHLRPEMALFYLRRDLKVFANLRPATVLPQLvdASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIKInENGEEVGIST 205
Cdd:COG0473    81 ---GVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGT-GTGEEVAIDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 206 EIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL-DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284
Cdd:COG0473   155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIE 364
Cdd:COG0473   235 VTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAIE 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1190990303 365 DAVVDALNKGFRTGDIYSPgnklVGCKEMGDEVLK 399
Cdd:COG0473   314 AAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIA 344
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 48-397 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 543.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  48 NIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKNE 127
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIkineNGEEVGISTEI 207
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 208 YAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTN 287
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 288 NIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAV 367
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 1190990303 368 VDALNKGFRTGDIYSPGNKLVGCKEMGDEV 397
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
48-397 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 522.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  48 NIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDknE 127
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVaEGVDMMIVRELTGGIYFGEPRGIKinENGEEVGISTEI 207
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNEV-EGVDIVIVRELTGGIYFGIEKGIK--GSGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 208 YAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLIRDPKQFDTIV 285
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 286 TNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIED 365
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1190990303 366 AVVDALNKGFRTGDIYSpGNKLVGCKEMGDEV 397
Cdd:pfam00180 316 AVLKVLESGIRTGDLAG-SATYVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
47-404 1.07e-84

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 261.59  E-value: 1.07e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  47 YNIALLPGDGIGPEVISVAKIVLQkagSLEgLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKN 126
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLD---ALD-LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 127 ekhlrpemALFYLRRDLKVFANLRPatvlpqlVDASTLKKEVAEGVDMMIVRELTGGIYFGeprgiKINENGEEVGISTE 206
Cdd:NF040626   78 --------PIITLRKELDLYANLRP-------IKSYEGINCLFKDLDFLIVRENTEGLYSG-----LEEEYTEEKAIAER 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 207 IYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284
Cdd:NF040626  138 VITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIE 364
Cdd:NF040626  218 VTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLE 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1190990303 365 DAVVDALNKG-FRTGDIYSPGNKLvgckEMGDEVLKSVESK 404
Cdd:NF040626  296 NALEKVLREGkVVTPDLGGNAKTM----EMANEIKKKIEEL 332
AksF_Meth NF040619
homoisocitrate dehydrogenase;
47-397 2.74e-68

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 219.24  E-value: 2.74e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  47 YNIALLPGDGIGPEVISVAKIVLQKAGsleglEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWD-- 124
Cdd:NF040619    2 PKICVIEGDGIGKEVIPETVRVLKELG-----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTel 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 125 KNEKHLRPemaLFYLRRDLKVFANLRPATVLPQLVDASTlkkevaegVDMMIVRELTGGIYFGEPRGIKINEngeeVGIS 204
Cdd:NF040619   77 KNKNYKSP---ILTLRKELDLYANVRPINNFGDGQDVKN--------IDFVIIRENTEGLYVGREYYDEENE----IAIA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 205 TEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEY--PDVELSHMYVDNAAMQLIRDPKQ 280
Cdd:NF040619  142 ERIISKKGSERIIKFAFEYAKKnNRKKVSCIHKANVLRVTDgLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEM 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAA 360
Cdd:NF040619  222 FDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKG 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1190990303 361 KRIEDAVVDALNKGFRTGDIyspGNKLvGCKEMGDEV 397
Cdd:NF040619  300 DLIREAVKKCLENGKVTPDL---GGNL-KTKEVTDKI 332
 
Name Accession Description Interval E-value
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 1-409 0e+00

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 792.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303   1 MAAFLQTNIRLNSIKIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKIVLQKAGSLEGLEF 80
Cdd:PLN02329    1 MAAFLQTNIRLNSIKIVPGRYSSLTDHQFRAPYRIRCAAASPGKKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  81 DFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160
Cdd:PLN02329   81 DFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIKINENGEEVGISTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240
Cdd:PLN02329  161 ASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320
Cdd:PLN02329  241 DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGDEVLKS 400
Cdd:PLN02329  321 FEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKS 400


                  ....*....
gi 1190990303 401 VESKVPATV 409
Cdd:PLN02329  401 VDSKVPATV 409
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 45-404 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 642.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  45 KRYNIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWD 124
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 125 KNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIkINENGEEVGIS 204
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGR-EGLGGEERAFD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 205 TEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284
Cdd:PRK00772  160 TMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVI 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIE 364
Cdd:PRK00772  240 VTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIE 319

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1190990303 365 DAVVDALNKGFRTGDIYsPGNKLVGCKEMGDEVLKSVESK 404
Cdd:PRK00772  320 AAVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALAEG 358
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 46-399 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 559.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  46 RYNIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDK 125
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWDD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 126 nekHLRPEMALFYLRRDLKVFANLRPATVLPQLvdASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIKInENGEEVGIST 205
Cdd:COG0473    81 ---GVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGT-GTGEEVAIDT 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 206 EIYAAHEIDRIARVAFETARKRRGKLCSVDKANVL-DASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284
Cdd:COG0473   155 RVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIE 364
Cdd:COG0473   235 VTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAIE 313

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1190990303 365 DAVVDALNKGFRTGDIYSPgnklVGCKEMGDEVLK 399
Cdd:COG0473   314 AAVEKVLAEGVRTPDLGGK----AGTSEMGDAIIA 344
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 48-397 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 543.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  48 NIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKNE 127
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGIkineNGEEVGISTEI 207
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGR----EGEGEAWDTEV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 208 YAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTN 287
Cdd:TIGR00169 157 YTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTS 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 288 NIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAV 367
Cdd:TIGR00169 237 NLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAV 316

                         330       340       350
                  ....*....|....*....|....*....|
gi 1190990303 368 VDALNKGFRTGDIYSPGNKLVGCKEMGDEV 397
Cdd:TIGR00169 317 KKVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
48-397 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 522.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  48 NIALLPGDGIGPEVISVAKIVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDknE 127
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 128 KHLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVaEGVDMMIVRELTGGIYFGEPRGIKinENGEEVGISTEI 207
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNEV-EGVDIVIVRELTGGIYFGIEKGIK--GSGNEVAVDTKL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 208 YAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASILWRKRVTALAS-EYPDVELSHMYVDNAAMQLIRDPKQFDTIV 285
Cdd:pfam00180 156 YSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVIV 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 286 TNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIED 365
Cdd:pfam00180 236 TPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEA 315

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1190990303 366 AVVDALNKGFRTGDIYSpGNKLVGCKEMGDEV 397
Cdd:pfam00180 316 AVLKVLESGIRTGDLAG-SATYVSTSEFGEAV 346
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 45-401 9.58e-86

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 264.48  E-value: 9.58e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  45 KRYNIALLPGDGIGPEVISVAKIVLQKAGSLeGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGykwd 124
Cdd:PRK03437    3 KTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGD---- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 125 knekhlrPEMA--------LFYLRRDLKVFANLRPATVLPQLvdASTLKKevAEGVDMMIVRELTGGIYFGEPRGIKINe 196
Cdd:PRK03437   78 -------PSVPsgvlerglLLKLRFALDHYVNLRPSKLYPGV--TSPLAG--PGDIDFVVVREGTEGPYTGNGGALRVG- 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 197 NGEEVGISTEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVL-DASILWRKRVTALASEYPDVELSHMYVDNAAMQL 274
Cdd:PRK03437  146 TPHEVATEVSVNTAFGVERVVRDAFERAQKRpRKHLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFM 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 275 IRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKY 352
Cdd:PRK03437  226 VTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGtnPSMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 1190990303 353 gLGEEKAAKRIEDAVVDalnkgfrtgDIYSPGNKLVGCKEMGDEVLKSV 401
Cdd:PRK03437  306 -LGEEDAAARIEAAVEA---------DLAERGKMGRSTAEVGDRIAARL 344
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 47-401 2.44e-85

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 263.15  E-value: 2.44e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  47 YNIALLPGDGIGPEVISVAKIVLQKAGslegLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDkn 126
Cdd:PRK14025    2 HKICVIEGDGIGKEVVPAALHVLEATG----LPFEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAAD-- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 127 ekhlrpemALFYLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFGEPRGIkinenGEEVGISTE 206
Cdd:PRK14025   76 --------VIVKLRRILDTYANVRPVKSYKGV-------KCLYPDIDYVIVRENTEGLYKGIEAEI-----ADGVTVATR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 207 IYAAHEIDRIARVAFETARKR-----RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQ 280
Cdd:PRK14025  136 VITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQT 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAA 360
Cdd:PRK14025  216 FDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKY-GLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEEA 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1190990303 361 KRIEDAVVDALNKGFRTGDIyspGNKLvGCKEMGDEVLKSV 401
Cdd:PRK14025  294 DKVEKALEEVLALGLTTPDL---GGNL-STMEMAEEVAKRV 330
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
47-404 1.07e-84

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 261.59  E-value: 1.07e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  47 YNIALLPGDGIGPEVISVAKIVLQkagSLEgLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWDKN 126
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLD---ALD-LNFDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 127 ekhlrpemALFYLRRDLKVFANLRPatvlpqlVDASTLKKEVAEGVDMMIVRELTGGIYFGeprgiKINENGEEVGISTE 206
Cdd:NF040626   78 --------PIITLRKELDLYANLRP-------IKSYEGINCLFKDLDFLIVRENTEGLYSG-----LEEEYTEEKAIAER 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 207 IYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTI 284
Cdd:NF040626  138 VITRKASERICKFAFEYAIKLgRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFDVI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 285 VTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIE 364
Cdd:NF040626  218 VTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANKLE 295

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1190990303 365 DAVVDALNKG-FRTGDIYSPGNKLvgckEMGDEVLKSVESK 404
Cdd:NF040626  296 NALEKVLREGkVVTPDLGGNAKTM----EMANEIKKKIEEL 332
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 44-401 1.69e-83

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 259.38  E-value: 1.69e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  44 KKRYNIALLPGDGIGPEVISVAKIVLQKAGSLEG-LEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYK 122
Cdd:TIGR02089   1 MKQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 123 wdKNEKHLRPEMALFYLRRDLKVFANLRPATVLPQLvdASTLKKEVAEGVDMMIVRELTGGIYFGEprGIKINEN-GEEV 201
Cdd:TIGR02089  81 --LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGV--TSPLRNCGPGDFDFVVVRENSEGEYSGV--GGRIHRGtDEEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 202 GISTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQ 280
Cdd:TIGR02089 155 ATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPET 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEK 358
Cdd:TIGR02089 235 FDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGkfPSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKE 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1190990303 359 AAKRIEDAVVDALNKGFRTGDIysPGNKlvGCKEMGDEVLKSV 401
Cdd:TIGR02089 314 AGAKIMDAIERVTAAGILTPDV--GGKA--TTSEVTEAVCNAL 352
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 49-398 1.35e-81

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 253.15  E-value: 1.35e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  49 IALLPGDGIGPEVISVAKIVLQKAGslegLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKwDKNEK 128
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNKLG----LEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPA-NPGYK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 129 HLrpemaLFYLRRDLKVFANLRPATVLPQLVDASTLkkevaeGVDMMIVRELTGGIYFGEPRGikinenGEEVGISTEIY 208
Cdd:TIGR02088  76 SV-----IVTLRKELDLYANVRPAKSLPGIPDLYPN------GKDIVIVRENTEGLYAGFEFG------FSDRAIAIRVI 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 209 AAHEIDRIARVAFETARKRRGKLCSVDKANVLDAS-ILWRKRVTALASEYpDVELSHMYVDNAAMQLIRDPKQFDTIVTN 287
Cdd:TIGR02088 139 TREGSERIARFAFNLAKERNRKVTCVHKANVLKGTdGLFREVCREIAKRY-GVEYRDMYVDSAAMNLVKDPWRFDVIVTT 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 288 NIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAV 367
Cdd:TIGR02088 218 NMFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDY-LGELEKGKLVWEAV 295

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1190990303 368 VDALNKGFRTGDIyspGNKLVgCKEMGDEVL 398
Cdd:TIGR02088 296 EYYIIEGKKTPDL---GGTAK-TKEVGDEIA 322
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 45-401 2.91e-74

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 235.39  E-value: 2.91e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  45 KRYNIALLPGDGIGPEVISVAKIVLQKAGSLEG-LEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGgykw 123
Cdd:PRK08194    2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVAEVHGgLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVG---- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 124 dkNEKHLRPEMALFYL----RRDLKVFANLRPATVLPQLVdaSTLKKevAEGVDMMIVRELTGGIYfgEPRGIKINENGE 199
Cdd:PRK08194   78 --NPKLVPDHISLWGLlikiRREFEQVINIRPAKQLRGIK--SPLAN--PKDFDLLVVRENSEGEY--SEVGGRIHRGED 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 200 EVGISTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASI-LWRKRVTALASEYPDVELSHMYVDNAAMQLIRDP 278
Cdd:PRK08194  150 EIAIQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNGIVHSMpFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRP 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 279 KQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESG--PGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGE 356
Cdd:PRK08194  230 EEFDVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGkyPSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGE 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1190990303 357 EKAAKRIEDAVVDALNKGFRTGDIyspGNKlVGCKEMGDEVLKSV 401
Cdd:PRK08194  309 EELGSHLLDVIEDVTEDGIKTPDI---GGR-ATTDEVTDEIISRL 349
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 49-377 1.21e-71

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 228.06  E-value: 1.21e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  49 IALLPGDGIGPEVISVAKIVLQKAGSleGLEFDFQEmpVGGAALDLVGVPMPEQTFTAAKQSDAILLGAI----GGYKWD 124
Cdd:PRK08997    5 ITVIPGDGIGPSIIDATLKILDKLGC--DFEYEFAD--AGLTALEKHGELLPQRTLDLIEKNKIALKGPLttpvGEGFTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 125 KNekhlrpemalFYLRRDLKVFANLRPATVLPQlvdastlKKEVAEGVDMMIVRELTGGIYFGEprGIKINENGEEvGIS 204
Cdd:PRK08997   81 IN----------VTLRKKFDLYANVRPVLSFPG-------TKARYDNIDIITVRENTEGMYSGE--GQTVSEDGET-AEA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 205 TEIYAAHEIDRIARVAFETARKR-RGKLCSVDKANVLDA-SILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282
Cdd:PRK08997  141 TSIITRKGAERIVRFAYELARKEgRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFD 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKR 362
Cdd:PRK08997  221 VIVTTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAER 298

                         330
                  ....*....|....*
gi 1190990303 363 IEDAVVDALNKGFRT 377
Cdd:PRK08997  299 IRKAIVAVIEAGDRT 313
AksF_Meth NF040619
homoisocitrate dehydrogenase;
47-397 2.74e-68

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 219.24  E-value: 2.74e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  47 YNIALLPGDGIGPEVISVAKIVLQKAGsleglEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIGGYKWD-- 124
Cdd:NF040619    2 PKICVIEGDGIGKEVIPETVRVLKELG-----DFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTel 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 125 KNEKHLRPemaLFYLRRDLKVFANLRPATVLPQLVDASTlkkevaegVDMMIVRELTGGIYFGEPRGIKINEngeeVGIS 204
Cdd:NF040619   77 KNKNYKSP---ILTLRKELDLYANVRPINNFGDGQDVKN--------IDFVIIRENTEGLYVGREYYDEENE----IAIA 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 205 TEIYAAHEIDRIARVAFETARK-RRGKLCSVDKANVLDASI-LWRKRVTALASEY--PDVELSHMYVDNAAMQLIRDPKQ 280
Cdd:NF040619  142 ERIISKKGSERIIKFAFEYAKKnNRKKVSCIHKANVLRVTDgLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEM 221

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 281 FDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESgPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAA 360
Cdd:NF040619  222 FDVIVTTNLFGDILSDEASGLIGGLGLAPSANIGDK-KGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKG 299

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1190990303 361 KRIEDAVVDALNKGFRTGDIyspGNKLvGCKEMGDEV 397
Cdd:NF040619  300 DLIREAVKKCLENGKVTPDL---GGNL-KTKEVTDKI 332
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
49-399 3.68e-58

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 197.42  E-value: 3.68e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  49 IALLPGDGIGPEVISVAKIVLQKAGSleGLEFDFQEMpvgGAALDLVGVP--MPEQTFTAAKQSDAILLGAI-----GGY 121
Cdd:PRK09222    7 ITVAYGDGIGPEIMEAVLKILEAAGA--PLEIETIEI---GEKVYKKGWTsgISPSAWESIRRTKVLLKAPIttpqgGGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 122 KwdknekhlrpemAL-FYLRRDLKVFANLRPATVLPQLVDAStlkkevAEGVDMMIVRE----LTGGIyfgEPRgikine 196
Cdd:PRK09222   82 K------------SLnVTLRKTLGLYANVRPCVSYHPFVETK------HPNLDVVIIREneedLYAGI---EHR------ 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 197 ngeevgISTEIYAAHEI------DRIARVAFETARKR-RGKLCSVDKANVLDASILWRKRV-TALASEYPDVELSHMYVD 268
Cdd:PRK09222  135 ------QTPDVYQCLKLisrpgsEKIIRYAFEYARANgRKKVTCLTKDNIMKLTDGLFHKVfDEIAKEYPDIEAEHYIVD 208

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 269 NAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAM 348
Cdd:PRK09222  209 IGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGLLNAAVM 287

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1190990303 349 LLKYgLGEEKAAKRIEDAVVDALNKGFRTGDIYSPG--NKLVGCKEMGDEVLK 399
Cdd:PRK09222  288 MLVH-IGQFDIAELIENAWLKTLEDGIHTADIYNEGvsKKKVGTKEFAEAVIE 339
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 1-380 1.47e-45

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 161.20  E-value: 1.47e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303   1 MAAFLQTNIRLNSIKIVPGRySSLTDHQFRAPYRIRCAAASPgkkrYNIALLPGDGIGPEVISVAKIVLQKAGslegLEF 80
Cdd:PLN00118    1 MAAQLLRRLLGNRLAQILGA-SSSSSGAFSSSARAFSSSSTP----ITATLFPGDGIGPEIAESVKQVFTAAG----VPI 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  81 DFQEMPVGGAaldlvgVPMPEQTFTAAKQSDAILLGAIGgykwdknekhLRPEMAL----------FYLRRDLKVFANLR 150
Cdd:PLN00118   72 EWEEHYVGTT------VDPRTGSFLTWESLESVRRNKVG----------LKGPMATpigkghrslnLTLRKELGLYANVR 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 151 PATVLPQLvdastlkKEVAEGVDMMIVRELTGGIYFG-EPRGIKinengeEVGISTEIYAAHEIDRIARVAFETARKR-R 228
Cdd:PLN00118  136 PCYSLPGY-------KTRYDDVDLVTIRENTEGEYSGlEHQVVR------GVVESLKIITRQASLRVAEYAFHYAKTHgR 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 229 GKLCSVDKANVLD-ASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGM 307
Cdd:PLN00118  203 KRVSAIHKANIMKkTDGLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLVMPNLYGDIISDLCAGLIGGLGL 282

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1190990303 308 LPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKG-FRTGDI 380
Cdd:PLN00118  283 TPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIHNAILNTIAEGkYRTADL 355
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 54-399 6.95e-39

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 144.10  E-value: 6.95e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  54 GDGIGPEVISVAKIVLQKAGSL---EGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAI-----GGYKwdk 125
Cdd:COG0538    26 GDGIGPEITRAIWKVIDAAVEKaygGKRDIEWKEVDAGEKARDETGDWLPDETAEAIKEYGVGIKGPLttpvgGGWR--- 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 126 nekhlRPEMALfylRRDLKVFANLRPATV---LPQLVdastlkKEvAEGVDMMIVRELTGGIY------FGEPRGIKI-- 194
Cdd:COG0538   103 -----SLNVTI---RQILDLYVCRRPVRYfkgVPSPV------KH-PEKVDIVIFRENTEDIYagiewkAGSPEALKLif 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 195 ---NENGEEV-------GISTEIYAAHEIDRIARVAFETA--RKRRgKLCSVDKANVL--------------------DA 242
Cdd:COG0538   168 fleDEMGVTVirfpedsGIGIKPVSDEGTERLVRAAIQYAldNKRK-SVTLVHKGNIMkftegafkdwgyevaeeefgDK 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 243 SI---LWRKRVTALASEypDVELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPG 319
Cdd:COG0538   247 FItegPWEKYKGPKPAG--KIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDGGA 324

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 320 LFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKGFRTGDI--YSPGNKLVGCKEMGDEV 397
Cdd:COG0538   325 EFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLarLMEGATELSTSEFGDAI 403


                  ..
gi 1190990303 398 LK 399
Cdd:COG0538   404 IE 405
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
54-403 3.78e-36

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 136.89  E-value: 3.78e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  54 GDGIGPEVISVAKIVLQKAGSL---EGLEFDFQEMPVGGAALDLVGVPMPEQTFTAAKQSDAILLGAIG---GYKWDKNE 127
Cdd:PRK06451   31 GDGIGPEITHAAMKVINKAVEKaygSDREIKWVEVLAGDKAEKLTGNRFPKESEELIEKYRVLLKGPLEtpiGKGWKSIN 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 128 KHLRpemalfyLRRDLkvFANLRPATVLPQLvdASTLKKevAEGVDMMIVRELTGGIYFG------EPRGIKIN------ 195
Cdd:PRK06451  111 VAIR-------LMLDL--YANIRPVKYIPGI--ESPLKN--PEKIDLIIFRENTDDLYRGieypydSEEAKKIRdflrke 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 196 ---ENGEEVGISTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLDAS-------------------ILWRKRVTA 252
Cdd:PRK06451  178 lgvEVEDDTGIGIKLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKYTegafrewayevalkefrdyVVTEEEVTK 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 253 LASEYPD---VELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAP 329
Cdd:PRK06451  258 NYNGVPPsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG-GMFEAIHGTAP 336

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1190990303 330 DIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKGFRTGDIYS-PGNKLVGCKEMGDEVLKSVES 403
Cdd:PRK06451  337 KYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfMGVRALSTTEYTDELISIIDM 410
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 27-380 1.16e-31

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 123.44  E-value: 1.16e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  27 HQFRAPYRIRCAAASPGKKRYN-IALLPGDGIGPEVISVAKIVLQKAGSleglEFDFQEMPVGGAALDLvgvpmPEQTFT 105
Cdd:PLN00123   10 LGSKAQRRSVTYMPRPGDGAPRaVTLIPGDGIGPLVTGAVEQVMEAMHA----PVYFERYEVHGDMKKV-----PEEVLE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 106 AAKQSDAILLGA----IGGYKWDKNEKhlrpemalfyLRRDLKVFANLRPATVLPQLvdastlkKEVAEGVDMMIVRELT 181
Cdd:PLN00123   81 SIRRNKVCLKGGlatpVGGGVSSLNVQ----------LRKELDLFASLVNCFNLPGL-------PTRHENVDIVVIRENT 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 182 GGIYFGEPrgikiNENGEEVGISTEIYAAHEIDRIARVAFETAR-KRRGKLCSVDKANVLD-ASILWRKRVTALASEYPD 259
Cdd:PLN00123  144 EGEYSGLE-----HEVVPGVVESLKVITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMKlADGLFLESCREVAKKYPG 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 260 VELSHMYVDNAAMQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGeSGPGLFEPIHGSA----PDIAGQD 335
Cdd:PLN00123  219 IKYNEIIVDNCCMQLVSKPEQFDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFEQGASAGnvgnEKLVEQK 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1190990303 336 KANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKG-FRTGDI 380
Cdd:PLN00123  298 KANPVALLLSSAMMLRH-LQFPSFADRLETAVKRVIAEGkYRTKDL 342
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 49-399 2.83e-20

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 92.05  E-value: 2.83e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303  49 IALLPGDGIGPEVISVAKIVL----QKAGSLEGlEFDFQEMPVGGAALDLVG--VPMPEQTFTAAKQSD-AI---LLGAI 118
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVdaavEKAYKGER-KISWMEIYAGEKATKVYGedVWLPEETLDLIREYRvAIkgpLTTPV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 119 GGYKWDKNekhlrpemalFYLRRDLKVFANLRPA---TVLPqlvdaSTLKKevAEGVDMMIVRELTGGIYFG------EP 189
Cdd:PRK07006  101 GGGIRSLN----------VALRQELDLYVCLRPVryfKGVP-----SPVKR--PEDTDMVIFRENSEDIYAGiewkagSA 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 190 RGIKI-----NENG-------EEVGISTEIYAAHEIDRIARVAFETA-RKRRGKLCSVDKANVLD-ASILWRKRVTALA- 254
Cdd:PRK07006  164 EAKKVikflqEEMGvkkirfpETSGIGIKPVSEEGTERLVRAAIEYAiDNDRKSVTLVHKGNIMKfTEGAFKDWGYQLAe 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 255 SEYPDVELS---HMYVDNAA----------------MQLIRDPKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGe 315
Cdd:PRK07006  244 EEFGDELIDggpWDKIKNPEtgkeiivkdsiadaflQQILLRPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGANIN- 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 316 SGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEEKAAKRIEDAVVDALNKGFRTGDIYS--PGNKLVGCKEM 393
Cdd:PRK07006  323 DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFARlmEGATEVKCSEF 401


                  ....*.
gi 1190990303 394 GDEVLK 399
Cdd:PRK07006  402 GDALIK 407
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
278-399 6.89e-16

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 78.99  E-value: 6.89e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1190990303 278 PKQFDTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGpGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYgLGEE 357
Cdd:PRK07362  350 PQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGVMMLEY-LGWQ 427

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1190990303 358 KAAKRIEDAVVDALNKGFRTGDI---YSPGNKLVGCKEMGDEVLK 399
Cdd:PRK07362  428 EAADLITKGLSAAIANKQVTYDLarlMEPPVDPLSCSEFAEAIIS 472
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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