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Conserved domains on  [gi|1176330883|ref|XP_020668558|]
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cyclin-K isoform X1 [Pogona vitticeps]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 40-177 9.78e-75

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 234.05  E-value: 9.78e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  40 GLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKT 119
Cdd:cd20530     1 GIDPETEARYRREGARFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEETPKKCKDIIKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176330883 120 ARSLLSDVQFGQFGDDPKqrnnplhrgssetghtecshmhtEEVMVLERILLQTIKFD 177
Cdd:cd20530    81 ARSLLNDKQFAQFGDDPK-----------------------EEVMVLERILLQTIKFD 115
CYCLIN_CCNK_rpt2 cd20531
second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA ...
 181-281 1.96e-70

second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410234 [Multi-domain]  Cd Length: 101  Bit Score: 222.21  E-value: 1.96e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQ 260
Cdd:cd20531     1 EHPYKYLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLCLQWEPEIIAVALMYLAAKLSKFDLQDWTSKPPGKRWWEQ 80

                          90       100
                  ....*....|....*....|.
gi 1176330883 261 FVQDVPVDVLEDICHQILDLY 281
Cdd:cd20531    81 FVEDVSLEVLEDICHQVLDLY 101
 
Name Accession Description Interval E-value
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 40-177 9.78e-75

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 234.05  E-value: 9.78e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  40 GLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKT 119
Cdd:cd20530     1 GIDPETEARYRREGARFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEETPKKCKDIIKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176330883 120 ARSLLSDVQFGQFGDDPKqrnnplhrgssetghtecshmhtEEVMVLERILLQTIKFD 177
Cdd:cd20530    81 ARSLLNDKQFAQFGDDPK-----------------------EEVMVLERILLQTIKFD 115
CYCLIN_CCNK_rpt2 cd20531
second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA ...
 181-281 1.96e-70

second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410234 [Multi-domain]  Cd Length: 101  Bit Score: 222.21  E-value: 1.96e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQ 260
Cdd:cd20531     1 EHPYKYLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLCLQWEPEIIAVALMYLAAKLSKFDLQDWTSKPPGKRWWEQ 80

                          90       100
                  ....*....|....*....|.
gi 1176330883 261 FVQDVPVDVLEDICHQILDLY 281
Cdd:cd20531    81 FVEDVSLEVLEDICHQVLDLY 101
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 25-240 4.82e-24

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 102.50  E-value: 4.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  25 YWDKKDLAH--TPSQLEGLDPAT----EARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGAC 98
Cdd:COG5333    14 PLLSFDSSQnaIELDLLVLEPELtlekELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  99 CLFLAGKVEETPKKckdiIKTARSLLSDVQfgqfgddpkqrnnplhrgSSETGHTEcshmhtEEVMVLERILLQTIKFDL 178
Cdd:COG5333    94 CVYLACKVEDTPRD----ISIESFEARDLW------------------SEEPKSSR------ERILEYEFELLEALDFDL 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176330883 179 QVEHPYQFLLKYAKQLKGDKNKiqKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRL 240
Cdd:COG5333   146 HVHHPYKYLEGFLKDLQEKDKY--KLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEV 205
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 55-121 1.66e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 66.08  E-value: 1.66e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176330883   55 RFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTAR 121
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTG 67
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 71-247 7.89e-09

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 57.54  E-value: 7.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  71 LATGIIYFHRFYMFHSFKQF-PRYVTgACCLFLAGKVEEtpkkckdiiktarSLLSDVQFGQfgddpKQRNNPLHRgsse 149
Cdd:TIGR00569  79 VGTAIMYFKRFYLNNSVMEYhPKIIM-LTCVFLACKVEE-------------FNVSIDQFVG-----NLKETPLKA---- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 150 tghtecshmhTEEVMVLERILLQTIKFDLQVEHPYQ----FLLKYAKQLKGDKNKiQKLVQMAWTFVNDSLCTTLSLQWE 225
Cdd:TIGR00569 136 ----------LEQVLEYELLLIQQLNFHLIVHNPYRplegFLIDIKTRLPGLENP-EYLRKHADKFLNRTLLTDAYLLYT 204

                         170       180
                  ....*....|....*....|....
gi 1176330883 226 PEIIAV-AVMYLAGRLC-KFEIQE 247
Cdd:TIGR00569 205 PSQIALaAILHTASRAGlNMESYL 228
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 56-178 9.78e-09

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 53.67  E-value: 9.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  56 FIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEET--PKkckdiiktarslLSDVQFgqfg 133
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIypPT------------VEDLVY---- 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1176330883 134 ddpkqrnnplhrgssETGHTeCSHmhtEEVMVLERILLQTIKFDL 178
Cdd:pfam00134 101 ---------------ITDNA-YTR---EEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 185-279 3.24e-06

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 45.28  E-value: 3.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  185 QFLLKYAKQLKGDknkiQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCkfEIQEWTSKpmyrrwWEQFVQD 264
Cdd:smart00385   1 DFLRRVCKALNLD----PETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKE------LVHYTGY 68

                           90
                   ....*....|....*
gi 1176330883  265 VPVDVLEDICHQILD 279
Cdd:smart00385  69 FTEEEILRMERLLLE 83
 
Name Accession Description Interval E-value
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 40-177 9.78e-75

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 234.05  E-value: 9.78e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  40 GLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKT 119
Cdd:cd20530     1 GIDPETEARYRREGARFIQDVGTKLGLPYDTIATGIVYFHRFYMFHSFKDFDRYVTAACCLFLAGKVEETPKKCKDIIKT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1176330883 120 ARSLLSDVQFGQFGDDPKqrnnplhrgssetghtecshmhtEEVMVLERILLQTIKFD 177
Cdd:cd20530    81 ARSLLNDKQFAQFGDDPK-----------------------EEVMVLERILLQTIKFD 115
CYCLIN_CCNK_rpt2 cd20531
second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA ...
 181-281 1.96e-70

second cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410234 [Multi-domain]  Cd Length: 101  Bit Score: 222.21  E-value: 1.96e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMYRRWWEQ 260
Cdd:cd20531     1 EHPYKYLLKYAKQLKGDKNKIQKLVQMAWTFVNDSLCTTLCLQWEPEIIAVALMYLAAKLSKFDLQDWTSKPPGKRWWEQ 80

                          90       100
                  ....*....|....*....|.
gi 1176330883 261 FVQDVPVDVLEDICHQILDLY 281
Cdd:cd20531    81 FVEDVSLEVLEDICHQVLDLY 101
CYCLIN_CCNT_rpt1 cd20538
first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 24-177 6.18e-38

first cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410241 [Multi-domain]  Cd Length: 137  Bit Score: 136.75  E-value: 6.18e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  24 WYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLA 103
Cdd:cd20538     2 WYFTREQLENTPSRRCGVDPDKELSYRQQAANLIQEMGQRLQVSQLCINTAIVYMHRFYMFHSFTKFHRNSIAAAALFLA 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176330883 104 GKVEETPKKCKDIIKTARSLlsdvqfgqfgddpkqrnnpLHRGSSETG-HTECSHMHTEEVMVLERILLQTIKFD 177
Cdd:cd20538    82 AKVEEQPRKLEHVIKVAHAC-------------------LHRGEPDLDtKSEAYLQQAQELVINENILLQTLGFE 137
CYCLIN_CCNT1_rpt1 cd20595
first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 24-177 3.74e-30

first cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410298 [Multi-domain]  Cd Length: 138  Bit Score: 115.54  E-value: 3.74e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  24 WYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLA 103
Cdd:cd20595     3 WYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFHRNSVAPAALFLA 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176330883 104 GKVEETPKKCKDIIKTARSLLsdvqfgqfgddpkqrnNPlhRGSSETGHTECSHMHTEEVMVLERILLQTIKFD 177
Cdd:cd20595    83 AKVEEQPKKLEHVIKVAHTCL----------------HP--QESLPDTRSEAYLQQVQDLVILESIILQTLGFE 138
CYCLIN_SpCG1C_ScCTK2-like_rpt2 cd20546
second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces ...
 182-283 3.73e-29

second cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1), Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2), and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. This group also includes yeast RNA polymerase II holoenzyme cyclin-like subunit, a component of the SRB8-11 complex, a regulatory module of the Mediator complex which is involved in regulation of basal and activated RNA polymerase II-dependent transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410249 [Multi-domain]  Cd Length: 97  Bit Score: 110.92  E-value: 3.73e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLKGDKNKiqKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMyRRWWEQF 261
Cdd:cd20546     1 HPYQYLIKFAKKLGVSDPK--ELAQLAWAFLNDSYRTPLCLLYPPHVIAAAAIYLAAKLLGIDLELSPNEKL-NEWWELF 77

                          90       100
                  ....*....|....*....|..
gi 1176330883 262 vqDVPVDVLEDICHQILDLYSQ 283
Cdd:cd20546    78 --GVDEEEIADAINEILDLYSS 97
CYCLIN_CCNT2_rpt1 cd20596
first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit ...
 24-177 9.23e-28

first cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410299 [Multi-domain]  Cd Length: 139  Bit Score: 108.60  E-value: 9.23e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  24 WYWDKKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLA 103
Cdd:cd20596     4 WFFTREQLENTPSRRCGVEADKELSYRQQAANLIQDMGQRLNVSQLTINTAIVYMHRFYMHHSFTKFHRNIISPTALFLA 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176330883 104 GKVEETPKKCKDIIKTARSLLSDVQfgqfgddpkqrnnPLHRGSSETghtecSHMHTEEVMVLERILLQTIKFD 177
Cdd:cd20596    84 AKVEEQPRKLEHVIKVAHACLNPLE-------------PQLDTKSDA-----YLQQAQELVILETIMLQTLGFE 139
CYCLIN_CCNL_rpt2 cd20533
second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 182-282 9.21e-25

second cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410236 [Multi-domain]  Cd Length: 92  Bit Score: 98.44  E-value: 9.21e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLKGDKNKiqKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEwtSKPmyrrWWEQF 261
Cdd:cd20533     1 HPHKFILMYLQVLEGEDNK--KLAQTAWNYMNDSLRTDLCVRYPPEVIACACIYLAARELGIPLPL--PPP----WWELF 72

                          90       100
                  ....*....|....*....|.
gi 1176330883 262 vqDVPVDVLEDICHQILDLYS 282
Cdd:cd20533    73 --DVSKEDIEEICLTILELYT 91
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 25-240 4.82e-24

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 102.50  E-value: 4.82e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  25 YWDKKDLAH--TPSQLEGLDPAT----EARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGAC 98
Cdd:COG5333    14 PLLSFDSSQnaIELDLLVLEPELtlekELNLVIYYLKLIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTT 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  99 CLFLAGKVEETPKKckdiIKTARSLLSDVQfgqfgddpkqrnnplhrgSSETGHTEcshmhtEEVMVLERILLQTIKFDL 178
Cdd:COG5333    94 CVYLACKVEDTPRD----ISIESFEARDLW------------------SEEPKSSR------ERILEYEFELLEALDFDL 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176330883 179 QVEHPYQFLLKYAKQLKGDKNKiqKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRL 240
Cdd:COG5333   146 HVHHPYKYLEGFLKDLQEKDKY--KLLQIAWKIINDALRTDLCLLYPPHIIALAALLIACEV 205
CYCLIN_SpCG1C-like_rpt1 cd20545
first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar ...
 46-178 3.72e-22

first cyclin box found in Schizosaccharomyces pombe cyclin C homolog 1 (pch1) and similar proteins; Cyclin pch1 is essential for progression through the whole cell cycle. It is a homolog of cyclin T; it forms a heterodimer with its partner kinase, cyclin-dependent kinase 9 (CDK9), that can phosphorylate both the pol II C-terminal domain (CTD) and the CTD of transcription elongation factor Spt5. Yeast Cdk9/Pch1, with mRNA capping enzyme Pct1, may also form an elongation checkpoint for mRNA quality control. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410248 [Multi-domain]  Cd Length: 116  Bit Score: 91.72  E-value: 3.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  46 EARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTArslls 125
Cdd:cd20545     1 EQEDRSKGVNFIIRVGSRLKLPQTTLFTAATYFHRFYMRNSLKKYHYYEIAATCLFLATKVEESGRKLRDIVIAC----- 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1176330883 126 dVQFGQFGDDPKQrnnplHRGSSETGHTECSHMHTEEVmvleriLLQTIKFDL 178
Cdd:cd20545    76 -AKVAQKNPNLVI-----DEQSKEVWRWRDSILYNEEV------LLETLCFDL 116
CYCLIN_CCNM_CCNQ_rpt1 cd20534
first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 50-177 6.00e-21

first cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410237 [Multi-domain]  Cd Length: 110  Bit Score: 88.00  E-value: 6.00e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  50 RREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLlsdvqf 129
Cdd:cd20534     2 HFKVLRFIREAGLKLELSSVTIATACVLYHRFYRELSLEDYDPYLVAMACLYLAGKAEEQPRRLRDIINVSYRI------ 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1176330883 130 gqfgddpkqrnnpLHRGSSETGHTECSHMHTEEVMVLERILLQTIKFD 177
Cdd:cd20534    76 -------------LHPDKPPLELDDEYWELRDSIVNCELLLLRILKFD 110
CYCLIN_AcCycT_rpt2 cd20588
second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 181-281 3.50e-19

second cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410291 [Multi-domain]  Cd Length: 93  Bit Score: 82.58  E-value: 3.50e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNKiqkLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQewtsKPMYRRWWEQ 260
Cdd:cd20588     1 EHPYKPLVAAIKKFNVAQNA---LAQAAWNFVNDGLRTSLCLQFKPHHIAAGAIFLAAKFLKVKLP----CDGRKVWWQE 73

                          90       100
                  ....*....|....*....|.
gi 1176330883 261 FvqDVPVDVLEDICHQILDLY 281
Cdd:cd20588    74 F--DVTPRQLEEVSNQMLELY 92
CYCLIN_CCNM_CCNQ_rpt2 cd20535
second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ...
 182-283 2.53e-18

second cyclin box found in cyclin-M (CCNM) family; The CCNM family proteins, also called ancient conserved domain proteins (ACDPs), are evolutionarily conserved Mg2+ transporters. CCNM, also called cyclin-Q (CCNQ), or CDK10-activating cyclin, or cyclin-related protein FAM58A, associates with CDK10 to promote its kinase activity. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410238 [Multi-domain]  Cd Length: 104  Bit Score: 80.38  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLK----GDKNKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKPMyrRW 257
Cdd:cd20535     1 LPHKYLLHYLKSLRdwlnPEFWSRSPIAKTAWSLLRDFYHSPLCLQFKPQHIALAVIYLALQVYGVKVPPEEEAEK--PW 78

                          90       100
                  ....*....|....*....|....*.
gi 1176330883 258 WEQFVQDVPVDVLEDICHQILDLYSQ 283
Cdd:cd20535    79 WQAFCEDLTKETIDEIIEDIINVYDL 104
CYCLIN_AcCycT_rpt1 cd20587
first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; ...
 39-177 3.19e-18

first cyclin box found in Arabidopsis thaliana T-type cyclins (CycTs) and similar proteins; CycTs associate with their partner cyclin-dependent kinases (CDKs) to trigger their kinase activity. CycTs show high sequence similarity with metazoan cyclin-K (CCNK). CycTs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410290 [Multi-domain]  Cd Length: 124  Bit Score: 81.03  E-value: 3.19e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  39 EGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIK 118
Cdd:cd20587     1 DGIDLKKETYLRKSYCTFLQDLGMRLKVPQVTIATAIVFCHRFFLRQSHAKNDRQTIATVCMFLAGKVEETPRPLKDVIV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1176330883 119 TARSLLsdvqfgqFGDDPKqrnnplhrGSSETGHTECSHMHTEEVMVLERILLQTIKFD 177
Cdd:cd20587    81 VSYEII-------FKKDPS--------AAQRIKQKEVYEQQKELVLNGEKLVLSTLGFD 124
CYCLIN_ScCTK2-like_rpt1 cd20547
first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar ...
 49-177 7.20e-18

first cyclin box found in Saccharomyces cerevisiae CTD kinase subunit 2 (ScCTK2) and similar proteins; CTK2, also called CTD kinase subunit beta, CTDK-I subunit beta, or CTD kinase 38 kDa subunit, is the cyclin subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. CTK2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410250 [Multi-domain]  Cd Length: 110  Bit Score: 79.31  E-value: 7.20e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  49 YRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLL---S 125
Cdd:cd20547     1 LRLAAFQFISQLCKKLKFPRRTLGTAMLLYQRFHLFNPFTDSSNYEVALACLFLASKIEDTQKKSKDILAASYNLRhpdK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1176330883 126 DVQFGQFGDDPKQRnnplhrgssetghtecshmhteeVMVLERILLQTIKFD 177
Cdd:cd20547    81 ISVDDQMLEEFRKA-----------------------ILGLERLLLETICFD 109
CYCLIN_CCNL_rpt1 cd20532
first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 ...
 39-117 4.08e-17

first cyclin box found in cyclin-L (CCNL) family; The CCNL family includes two cyclins, CCNL1 and CCNL2. CCNL1 is involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL2 is a novel RNA polymerase II-associated cyclin involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410235 [Multi-domain]  Cd Length: 127  Bit Score: 77.98  E-value: 4.08e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176330883  39 EGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDII 117
Cdd:cd20532     1 DGIDEETEIDLRIYGCELIQDAGILLKLPQVVMATAQVLFHRFYYRKSLRKFDVKIVAMACLFLASKIEETPRRLRDVI 79
CYCLIN_AcCycL_rpt2 cd20594
second cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 180-287 3.26e-15

second cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410297 [Multi-domain]  Cd Length: 101  Bit Score: 71.43  E-value: 3.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 180 VEHPYQFLLKYAKQLKgdknKIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRlcKFEIqewtSKPMYRRWWE 259
Cdd:cd20594     2 VEHPHKFILNYLAMLM----APPELRQEAWNLANDSLRTTLCVRFKSEVVACGVVYAAAR--RFQV----PLPENPPWWK 71

                          90       100
                  ....*....|....*....|....*...
gi 1176330883 260 QFvqDVPVDVLEDICHQILDLYSQGKQQ 287
Cdd:cd20594    72 VF--DAEKAEIDVVCKVLADLYRQPKAR 97
CYCLIN_CCNC_rpt2 cd20514
second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 182-287 3.78e-14

second cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410218 [Multi-domain]  Cd Length: 92  Bit Score: 68.03  E-value: 3.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLKGDKNkiqkLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKpmyrrwweqf 261
Cdd:cd20514     1 HPYRPLTQYVQDAGLDDE----LLPLAWRIVNDSYRTDVCLLYPPYLIALACLHMACVLLQKDARQWFAE---------- 66

                          90       100
                  ....*....|....*....|....*.
gi 1176330883 262 vQDVPVDVLEDICHQILDLYSQGKQQ 287
Cdd:cd20514    67 -LNVDMDKILEITREILSLYELWKTF 91
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 52-128 1.28e-13

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 66.28  E-value: 1.28e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176330883  52 EGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTARSLLSDVQ 128
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPRTLKEIAKVSGVSEKELR 77
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 55-121 1.66e-13

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 66.08  E-value: 1.66e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1176330883   55 RFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDIIKTAR 121
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTG 67
CYCLIN_CCNL1_rpt2 cd20592
second cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 181-291 3.39e-13

second cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410295 [Multi-domain]  Cd Length: 123  Bit Score: 66.56  E-value: 3.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNkiQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIqewTSKPmyrRWWEQ 260
Cdd:cd20592     1 KHPHKIIVMYLQVLECERN--QTLVQTAWNYMNDSLRTNVFVRFQPETIACACIYLAARALQIPL---PNRP---HWFLL 72

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1176330883 261 FvqDVPVDVLEDICHQILDLYSQGKqqmPHH 291
Cdd:cd20592    73 F--GATEEEIQEICITTLKLYTRKK---PNY 98
CYCLIN_CCNC_rpt1 cd20513
first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or ...
 56-126 6.40e-13

first cyclin box found in cyclin-C (CCNC) and similar proteins; CCNC, also termed CycC, or SRB11, is a component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. It mediates stress-induced mitochondrial fission and apoptosis. CCNC contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410217 [Multi-domain]  Cd Length: 101  Bit Score: 64.92  E-value: 6.40e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176330883  56 FIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQF-PRYVtGACCLFLAGKVEETPKKCKDIIKTARSLLSD 126
Cdd:cd20513     8 FIQALGERLKLRQRVIATAIVYFKRFYARNSFKDIdPRLV-APTCLYLASKVEECPSHARLIVAEAKVLKTK 78
CYCLIN_CCNL2_rpt2 cd20593
second cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 182-290 8.20e-13

second cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410296 [Multi-domain]  Cd Length: 123  Bit Score: 65.37  E-value: 8.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLKGDKNkiQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIqewtskPMYRRWWEQF 261
Cdd:cd20593     1 HPHKIIVMYLQVLECERN--RHLVQTSWNYMNDSLRTDVFVRFNPETIACACIYLAARTLEIPL------PNRPHWFLLF 72

                          90       100
                  ....*....|....*....|....*....
gi 1176330883 262 vqDVPVDVLEDICHQILDLYSQGKQQMPH 290
Cdd:cd20593    73 --GATEEEIQEICLKILQLYTRKKVDLEH 99
CYCLIN_AcCycL_rpt1 cd20591
first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; ...
 36-176 1.27e-12

first cyclin box found in Arabidopsis thaliana L-type cyclins (CycL) and similar proteins; Cyclin-L1-1 (CycL1), also called arginine-rich cyclin 1 (AtRCY1), or protein MODIFIER OF SNC1 12, is the cognate cyclin for cyclin-dependent kinase G1 (CDKG1). It is involved in regulation of DNA methylation and transcriptional silencing. It is required for synapsis and male meiosis, and for the proper splicing of specific resistance (R) genes. L-type cyclins contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410294 [Multi-domain]  Cd Length: 128  Bit Score: 64.86  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  36 SQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKD 115
Cdd:cd20591     1 SRKDGIDEDTEITLRIFGCELIQESGILLKLPQAVMATGQVLFQRFYCKKSFARFNVKRVAASCVWLAAKLEESPRKIRQ 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1176330883 116 IIKTarsllsdvqfgqFGDDPKQRNN-PLHRGSSETghTECSHMhTEEVMVLERILLQTIKF 176
Cdd:cd20591    81 VLMV------------FHRMECRRENlPLEPLEPES--KKYDEM-KEDLIRTERHLLKEMGF 127
CYCLIN_CCNL2_rpt1 cd20590
first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA ...
 31-117 1.60e-11

first cyclin box found in cyclin-2 (CCNL2) and similar proteins; CCNL2 is a novel RNA polymerase II-associated cyclin that is involved in pre-mRNA splicing. It may induce cell death, possibly by acting on the transcription and RNA processing of apoptosis-related factors. CCNL2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410293 [Multi-domain]  Cd Length: 156  Bit Score: 62.72  E-value: 1.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  31 LAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETP 110
Cdd:cd20590    25 LRFTPSMSSGLDVDTETDLRVVGCELIQAAGILLRLPQVAMATGQVLFQRFFYTKSFVKHSMEHVSMACVHLASKIEEAP 104


                  ....*..
gi 1176330883 111 KKCKDII 117
Cdd:cd20590   105 RRIRDVI 111
CYCLIN_CCNL1_rpt1 cd20589
first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin ...
 39-117 1.74e-10

first cyclin box found in cyclin-L1 (CCNL1) and similar proteins; CCNL1 is an L-type cyclin involved in the regulation of RNA polymerase II (pol II) transcription. It functions in association with cyclin-dependent kinases (CDKs). CCNL1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410292 [Multi-domain]  Cd Length: 124  Bit Score: 58.99  E-value: 1.74e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1176330883  39 EGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEETPKKCKDII 117
Cdd:cd20589     1 DGLDHETETDLRILGCELIQTAGILLRLPQVAMATGQVLFQRFFYSKSFVKHSMEIVAMACINLASKIEEAPRRIRDVI 79
ccl1 TIGR00569
cyclin ccl1; All proteins in this family for which functions are known are cyclins that are ...
 71-247 7.89e-09

cyclin ccl1; All proteins in this family for which functions are known are cyclins that are components of TFIIH, a complex that is involved in nucleotide excision repair and transcription initiation. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, StanfordUniversity). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129660 [Multi-domain]  Cd Length: 305  Bit Score: 57.54  E-value: 7.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  71 LATGIIYFHRFYMFHSFKQF-PRYVTgACCLFLAGKVEEtpkkckdiiktarSLLSDVQFGQfgddpKQRNNPLHRgsse 149
Cdd:TIGR00569  79 VGTAIMYFKRFYLNNSVMEYhPKIIM-LTCVFLACKVEE-------------FNVSIDQFVG-----NLKETPLKA---- 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 150 tghtecshmhTEEVMVLERILLQTIKFDLQVEHPYQ----FLLKYAKQLKGDKNKiQKLVQMAWTFVNDSLCTTLSLQWE 225
Cdd:TIGR00569 136 ----------LEQVLEYELLLIQQLNFHLIVHNPYRplegFLIDIKTRLPGLENP-EYLRKHADKFLNRTLLTDAYLLYT 204

                         170       180
                  ....*....|....*....|....
gi 1176330883 226 PEIIAV-AVMYLAGRLC-KFEIQE 247
Cdd:TIGR00569 205 PSQIALaAILHTASRAGlNMESYL 228
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 56-178 9.78e-09

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 53.67  E-value: 9.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  56 FIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQFPRYVTGACCLFLAGKVEET--PKkckdiiktarslLSDVQFgqfg 133
Cdd:pfam00134  37 WLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAAKYEEIypPT------------VEDLVY---- 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1176330883 134 ddpkqrnnplhrgssETGHTeCSHmhtEEVMVLERILLQTIKFDL 178
Cdd:pfam00134 101 ---------------ITDNA-YTR---EEILRMERLILETLNFDL 126
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 28-125 7.05e-08

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 51.83  E-value: 7.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  28 KKDLAHTPSQLEGLDPATEARYRREGARFIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQF-PRYVTgACCLFLAGKV 106
Cdd:cd20524    33 KESLKEEDAEPKFLTPEEELLLVRYYEKKLLEFCRAFKLPDSVLATALTYFKRFYLKNSVMEYhPKEIM-LTCLYLACKV 111

                          90       100
                  ....*....|....*....|....*.
gi 1176330883 107 EETP-------KKCKDIIKTARSLLS 125
Cdd:cd20524   112 EEFNisidqfvGNIKESEKTAEIILE 137
CYCLIN_AtCycC_rpt2 cd20572
second cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 182-281 7.42e-07

second cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410275 [Multi-domain]  Cd Length: 102  Bit Score: 47.85  E-value: 7.42e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLkyakQLKGDKNkIQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEIqewtskpmyRRWWEQF 261
Cdd:cd20572     1 HPYRPLI----QLLQDAG-LTDMTQFTWSIVNDTYRTDLILIHPPYMIALACIYIASVHKEKDI---------TLWFEEL 66

                          90       100
                  ....*....|....*....|
gi 1176330883 262 VQDvpVDVLEDICHQILDLY 281
Cdd:cd20572    67 RVD--MNIIKNIAMEILDFY 84
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 185-279 3.24e-06

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 45.28  E-value: 3.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  185 QFLLKYAKQLKGDknkiQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCkfEIQEWTSKpmyrrwWEQFVQD 264
Cdd:smart00385   1 DFLRRVCKALNLD----PETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTE--ETPPWTKE------LVHYTGY 68

                           90
                   ....*....|....*
gi 1176330883  265 VPVDVLEDICHQILD 279
Cdd:smart00385  69 FTEEEILRMERLLLE 83
CYCLIN_CCNT2_rpt2 cd20598
second cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory ...
 181-298 2.12e-05

second cyclin box found in cyclin-T2 (CCNT2); CCNT2, also termed CycT2, is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to production elongation by phosphorylating the CTD (carboxy-terminal domain) of the large subunit of RNA polymerase II (RNAP II). CCNT2 contains two cyclin boxs. The model responds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410301 [Multi-domain]  Cd Length: 114  Bit Score: 43.92  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNkiqkLVQMAWTFVNDSL-CTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKpmyRRWWE 259
Cdd:cd20598     1 EHPHTDVVKCTQLVRASKD----LAQTSYFMATNSLhLTTFCLQYKPTVIACVCIHLACKWSNWEIPVSTDG---KHWWE 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1176330883 260 QFVQDVPVDVLEDICHQILdlysqgkqQMPHHTPHQLQQ 298
Cdd:cd20598    74 YVDPTVTLELLDELTHEFL--------QILEKTPSRLKR 104
CYCLIN_CCNT1_rpt2 cd20597
second cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor ...
 181-298 3.76e-05

second cyclin box found in cyclin-T1 (CCNT1); CCNT1, also termed CycT1, is a host factor essential for HIV-1 replication in CD4 T cells and macrophages. It is a regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). CCNT1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410300 [Multi-domain]  Cd Length: 109  Bit Score: 43.14  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 181 EHPYQFLLKYAKQLKGDKNkiqkLVQMAWTFVNDSL-CTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKpmyRRWWE 259
Cdd:cd20597     1 DHPHTHVVKCTQLVRASKD----LAQTSYFMATNSLhLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDG---KHWWE 73

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1176330883 260 QFVQDVPVDVLEDICHQILdlysqgkqQMPHHTPHQLQQ 298
Cdd:cd20597    74 YVDATVTLELLDELTHEFL--------QILEKTPNRLKR 104
CYCLIN_CCNT_rpt2 cd20539
second cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, ...
 182-278 4.30e-05

second cyclin box found in cyclin-T (CCNT) family; The CCNT family includes two C-type cyclins, cyclin-T1 (CCNT1) and cyclin-T2 (CCNT2), both of which are regulatory subunits of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor B (P-TEFb), which is proposed to facilitate the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II). Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410242 [Multi-domain]  Cd Length: 92  Bit Score: 42.65  E-value: 4.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLK-GDKNkiqkLVQMAWTFVNDSL-CTTLSLQWEPEIIAVAVMYLAGRLCKFEIQEWTSKpmyRRWWE 259
Cdd:cd20539     1 HPHTHVLKICNLVKaGSKD----LAQTAYFLATNSLhLTTFCLQYKPTVIACVCIHLACKWSNWEIPRSSEG---KDWYE 73

                          90
                  ....*....|....*....
gi 1176330883 260 QFVQDVPVDVLEDICHQIL 278
Cdd:cd20539    74 YVDPSLTLEELDELTSEFL 92
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 182-245 1.34e-04

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 40.86  E-value: 1.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1176330883 182 HPYQFLLKYAKQLKGDknkiQKLVQMAWTFVNDSLCTTLSLQWEPEIIAVAVMYLAGRLCKFEI 245
Cdd:cd00043     1 KAVDFIRRLCSKLGLP----EEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPR 60
CYCLIN_AtCycC_rpt1 cd20571
first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; ...
 56-129 4.37e-04

first cyclin box found in Arabidopsis thaliana C-type cyclins (CycCs) and similar proteins; Plant CycCs are the cognate cyclin partners of cyclin-dependent kinase CDK8. They may be involved in cell cycle control. CycCs contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410274 [Multi-domain]  Cd Length: 107  Bit Score: 40.22  E-value: 4.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1176330883  56 FIFDVGTRLGLHYDTLATGIIYFHRFYMFHSFKQF-PRYVtGACCLFLAGKVEETPKKCKDIIKTARSLLSDVQF 129
Cdd:cd20571    13 YIKKLAQHIKVRQRVVATAITYFRRVYTRKSFTEYdPRLV-APTCLYLASKAEESTVQAKLLVFYMKRLYADEYH 86
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 182-283 1.33e-03

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 38.06  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883 182 HPYQFLLKYAKQLKGDKnkiqKLVQMAWtFVND-SLCTTLSLQWEPEIIAVAVMYLAGRLCKfeIQEWTSKPMYRRWWEQ 260
Cdd:cd20537     2 TPLSFLRRYLSLLGLDE----KVRHLAR-YLLElSLLDYEFLKYRPSLIAAAALYLARKILG--EPPPSPQLLQLVTGYS 74

                          90       100
                  ....*....|....*....|...
gi 1176330883 261 FvqdvpvDVLEDICHQILDLYSQ 283
Cdd:cd20537    75 E------NDLQECAKELLELLAQ 91
CYCLIN_AcCycH_rpt1 cd20585
first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH ...
 71-108 7.74e-03

first cyclin box found in Arabidopsis thaliana H-type cyclin (CycH) and similar proteins; CycH associates with and activates the cyclin-dependent kinases, CDK-2 and CDK-3. CycH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410288  Cd Length: 170  Bit Score: 37.88  E-value: 7.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1176330883  71 LATGIIYFHRFYMFHSFKQF-PRYVTgACCLFLAGKVEE 108
Cdd:cd20585    99 QATALLYFKRFYLQWSVMEHdPKRIM-LTCIYLACKVEE 136
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 50-178 8.62e-03

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 36.14  E-value: 8.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1176330883  50 RREGARFIFDVGTRLGLHYDTLATGIIYFHRFymFHSFKQFPRYV--TGACCLFLAGKVEETpkkcKDIIKTARSLLSDV 127
Cdd:cd20526     2 RDEAVRWLAELNSQFKFYPETFALAVSILDRF--LASVKARPKYLrcIAISCLFLAAKTNEE----DEVIPSTKDLVRVS 75

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1176330883 128 QFGqfgddpkqrnnplhrgssetghteCShmhTEEVMVLERILLQTIKFDL 178
Cdd:cd20526    76 KCG------------------------CS---VAEVLRMERIILDKLHWDL 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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