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Conserved domains on  [gi|1133441421|ref|XP_019877143|]
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uncharacterized protein LOC109605020 [Aethina tumida]

Protein Classification

RIIa domain-containing protein 1( domain architecture ID 17786486)

RIIa domain-containing protein 1 (RIIAD1) is the regulatory subunit of type II PKA R-subunit domain containing 1

CATH:  1.20.890.10
Gene Ontology:  GO:0046983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DD_RIIAD1 cd22971
dimerization/docking (D/D) domain found in RIIa domain-containing protein 1 (RIIAD1) and ...
 61-102 3.83e-11

dimerization/docking (D/D) domain found in RIIa domain-containing protein 1 (RIIAD1) and similar proteins; The family includes uncharacterized RIIa domain-containing protein 1 (RIIAD1), which contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of cAMP-dependent protein kinase (PKA).


:

Pssm-ID: 438540  Cd Length: 41  Bit Score: 53.95  E-value: 3.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1133441421  61 QEHPEVEAIIMLILRKVFQRqKPTNIIQFVAQYFHQSFYDIE 102
Cdd:cd22971     1 REHPEIRALISGFLREVLKK-KPENIREFAAEFFTDPRLPIK 41
 
Name Accession Description Interval E-value
DD_RIIAD1 cd22971
dimerization/docking (D/D) domain found in RIIa domain-containing protein 1 (RIIAD1) and ...
 61-102 3.83e-11

dimerization/docking (D/D) domain found in RIIa domain-containing protein 1 (RIIAD1) and similar proteins; The family includes uncharacterized RIIa domain-containing protein 1 (RIIAD1), which contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of cAMP-dependent protein kinase (PKA).


Pssm-ID: 438540  Cd Length: 41  Bit Score: 53.95  E-value: 3.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1133441421  61 QEHPEVEAIIMLILRKVFQRqKPTNIIQFVAQYFHQSFYDIE 102
Cdd:cd22971     1 REHPEIRALISGFLREVLKK-KPENIREFAAEFFTDPRLPIK 41
 
Name Accession Description Interval E-value
DD_RIIAD1 cd22971
dimerization/docking (D/D) domain found in RIIa domain-containing protein 1 (RIIAD1) and ...
 61-102 3.83e-11

dimerization/docking (D/D) domain found in RIIa domain-containing protein 1 (RIIAD1) and similar proteins; The family includes uncharacterized RIIa domain-containing protein 1 (RIIAD1), which contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of cAMP-dependent protein kinase (PKA).


Pssm-ID: 438540  Cd Length: 41  Bit Score: 53.95  E-value: 3.83e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1133441421  61 QEHPEVEAIIMLILRKVFQRqKPTNIIQFVAQYFHQSFYDIE 102
Cdd:cd22971     1 REHPEIRALISGFLREVLKK-KPENIREFAAEFFTDPRLPIK 41
DD_CATIP cd22973
dimerization/docking (D/D) domain found in ciliogenesis-associated TTC17-interacting protein ...
 58-94 1.40e-04

dimerization/docking (D/D) domain found in ciliogenesis-associated TTC17-interacting protein (CATIP) and similar proteins; CATIP, also called C2orf62, plays a role in primary ciliogenesis by modulating actin polymerization. It interacts with TTC17. Mutations in CATIP may contribute to asthenozoospermia through its involvement in actin polymerization and the actin cytoskeleton. CATIP contains a C-terminal domain that shows high sequence similarity to the dimerization/docking (D/D) domain of regulatory subunit of cAMP-dependent protein kinase (PKA).


Pssm-ID: 438542  Cd Length: 40  Bit Score: 37.06  E-value: 1.40e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1133441421  58 EYLQEHPEVEAIIMLILRKVFQRqKPTNIIQFVAQYF 94
Cdd:cd22973     1 KYLRDHPELKAILSDFLQALLLR-KPEDVYQFAAEYF 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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