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Conserved domains on  [gi|1126159208|ref|XP_019618596|]
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PREDICTED: MLX-interacting protein-like isoform X11 [Branchiostoma belcheri]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 151-261 2.11e-71

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


:

Pssm-ID: 439286  Cd Length: 113  Bit Score: 232.92  E-value: 2.11e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  151 SIDASLTKLFECMTLAYNGKLVSPKWKTFKGLKLLWKDKIRLNNAIWRAWHIQYINKKSPLVCQFvANPLADDAHSLPQA 230
Cdd:cd21739      1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQF-AVPLDDDTHKKPEA 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1126159208  231 VVLEGKYWKRRMETVVKEYMKWRVYYKKKTA 261
Cdd:cd21739     80 VVLEGKYWKRRLETVVREYKKWRLFYKDKLA 110
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 995-1068 4.07e-40

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


:

Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 142.41  E-value: 4.07e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  995 DQRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEI 1068
Cdd:cd11405      1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 514-929 3.23e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  514 ISVLAQNTRPTQPPHIHSSQPASMSTSTQQVSQVIAAPTPITPSSTAHQQPPTMLPMYQAQPNI---------PVMPSTQ 584
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadvtsptPAGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  585 TAFQTPTSSPQPNVAPFGFPQQQQQKTQTIQPMPalqqqqqqqivsqgnyagfTTVSTLPASTfmetddqqqqqhqqQQQ 664
Cdd:pfam05109  485 ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTP-------------------NATSPTPAVT--------------TPT 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  665 QQQPAPTRSRTTPKQypLAPKPAPSATIQQGALGFTTQNAMQVAFTQNSLQQGVNSNTvqfikPKGLSPIAPKPSTTASQ 744
Cdd:pfam05109  532 PNATSPTLGKTSPTS--AVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT-----PNATSPTVGETSPQANT 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  745 TATILTASVGSPqgVGGSGDKTHTVSVqntflaqlltggsgaftTQGIQPCTSAGTSTMSNQVYLTSSAIKPDTSLLNTV 824
Cdd:pfam05109  605 TNHTLGGTSSTP--VVTSPPKNATSAV-----------------TTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTS 665

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  825 VTPSTTqgfvlAANPS---QLAQSPQPTTATYQekvagVTDFQSSVLVAAAAQAGKVGlpglATATKVERKSPPVACSTP 901
Cdd:pfam05109  666 HMPLLT-----SAHPTggeNITQVTPASTSTHH-----VSTSSPAPRPGTTSQASGPG----NSSTSTKPGEVNVTKGTP 731

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1126159208  902 IKPASTPNSPSA---ASPITTEDSPGHNSET 929
Cdd:pfam05109  732 PKNATSPQAPSGqktAVPTVTSTGGKANSTT 762
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 151-261 2.11e-71

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 232.92  E-value: 2.11e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  151 SIDASLTKLFECMTLAYNGKLVSPKWKTFKGLKLLWKDKIRLNNAIWRAWHIQYINKKSPLVCQFvANPLADDAHSLPQA 230
Cdd:cd21739      1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQF-AVPLDDDTHKKPEA 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1126159208  231 VVLEGKYWKRRMETVVKEYMKWRVYYKKKTA 261
Cdd:cd21739     80 VVLEGKYWKRRLETVVREYKKWRLFYKDKLA 110
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 995-1068 4.07e-40

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 142.41  E-value: 4.07e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  995 DQRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEI 1068
Cdd:cd11405      1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
HLH pfam00010
Helix-loop-helix DNA-binding domain;
997-1051 4.93e-12

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 61.71  E-value: 4.93e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQ 1051
Cdd:pfam00010    1 RREAHNERERRRRDRINDAFDELRELLPTLPP--DKKLSKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
1004-1056 8.71e-11

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 58.38  E-value: 8.71e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1126159208  1004 AEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQAERQQ 1056
Cdd:smart00353    3 RERRRRRKINEAFDELRSLLPTLPK--NKKLSKAEILRLAIEYIKSLQEELQK 53
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 514-929 3.23e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  514 ISVLAQNTRPTQPPHIHSSQPASMSTSTQQVSQVIAAPTPITPSSTAHQQPPTMLPMYQAQPNI---------PVMPSTQ 584
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadvtsptPAGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  585 TAFQTPTSSPQPNVAPFGFPQQQQQKTQTIQPMPalqqqqqqqivsqgnyagfTTVSTLPASTfmetddqqqqqhqqQQQ 664
Cdd:pfam05109  485 ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTP-------------------NATSPTPAVT--------------TPT 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  665 QQQPAPTRSRTTPKQypLAPKPAPSATIQQGALGFTTQNAMQVAFTQNSLQQGVNSNTvqfikPKGLSPIAPKPSTTASQ 744
Cdd:pfam05109  532 PNATSPTLGKTSPTS--AVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT-----PNATSPTVGETSPQANT 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  745 TATILTASVGSPqgVGGSGDKTHTVSVqntflaqlltggsgaftTQGIQPCTSAGTSTMSNQVYLTSSAIKPDTSLLNTV 824
Cdd:pfam05109  605 TNHTLGGTSSTP--VVTSPPKNATSAV-----------------TTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTS 665

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  825 VTPSTTqgfvlAANPS---QLAQSPQPTTATYQekvagVTDFQSSVLVAAAAQAGKVGlpglATATKVERKSPPVACSTP 901
Cdd:pfam05109  666 HMPLLT-----SAHPTggeNITQVTPASTSTHH-----VSTSSPAPRPGTTSQASGPG----NSSTSTKPGEVNVTKGTP 731

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1126159208  902 IKPASTPNSPSA---ASPITTEDSPGHNSET 929
Cdd:pfam05109  732 PKNATSPQAPSGqktAVPTVTSTGGKANSTT 762
PHA03247 PHA03247
large tegument protein UL36; Provisional
 458-931 1.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  458 PPEER-PSASATVSSPPFQNQMSADTMQYQGRSQAGM----SYQESSPIQMDTNQTSLEDAISVLAQNTRPTQPPHIHSS 532
Cdd:PHA03247  2483 PAEARfPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAIlpdePVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPA 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  533 QPasmstsTQQVSQVIAAPTPITPSSTAHQQPPTMlPMYQAQPNIPVMPSTQTAFQTPTSSPQPNVAPFGFPQQQQQKTQ 612
Cdd:PHA03247  2563 AP------DRSVPPPRPAPRPSEPAVTSRARRPDA-PPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  613 TIQPMPALQQQQQQQIVSQGNYAGFTTVSTLPASTFMETDDQQQQQHQQQQQQQQP-APTRSRTTPKQYPLAPKPAPSAT 691
Cdd:PHA03247  2636 NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEPAPHAL 2715

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  692 IQQGALGFTTQNAMQVAftqnslqqgvnsntvqfiKPKGLSPIAPKPSTTASQTATIltASVGSPQGVGGSGDKTHTvsv 771
Cdd:PHA03247  2716 VSATPLPPGPAAARQAS------------------PALPAAPAPPAVPAGPATPGGP--ARPARPPTTAGPPAPAPP--- 2772

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  772 qntflAQLLTGGSGAFTTQGIQPCTSAGTSTMS-NQVYLTSSAIKPDTSLLNTVVTPSTTQGFVLAANP--SQLAQSPQP 848
Cdd:PHA03247  2773 -----AAPAAGPPRRLTRPAVASLSESRESLPSpWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPtaPPPPPGPPP 2847

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  849 TTATYQEKVAGVTDF------QSSVLVAAAA---QAGKVGLPGLATATK--------VERKSPPVAcstPIKPASTPNSP 911
Cdd:PHA03247  2848 PSLPLGGSVAPGGDVrrrppsRSPAAKPAAParpPVRRLARPAVSRSTEsfalppdqPERPPQPQA---PPPPQPQPQPP 2924

                          490       500
                   ....*....|....*....|
gi 1126159208  912 SAASPITTEDSPGHNSETLA 931
Cdd:PHA03247  2925 PPPQPQPPPPPPPRPQPPLA 2944
 
Name Accession Description Interval E-value
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 151-261 2.11e-71

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 232.92  E-value: 2.11e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  151 SIDASLTKLFECMTLAYNGKLVSPKWKTFKGLKLLWKDKIRLNNAIWRAWHIQYINKKSPLVCQFvANPLADDAHSLPQA 230
Cdd:cd21739      1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQF-AVPLDDDTHKKPEA 79

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1126159208  231 VVLEGKYWKRRMETVVKEYMKWRVYYKKKTA 261
Cdd:cd21739     80 VVLEGKYWKRRLETVVREYKKWRLFYKDKLA 110
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 151-259 5.53e-58

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 195.19  E-value: 5.53e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  151 SIDASLTKLFECMTLAYNGKLVSPKWKTFKGLKLLWKDKIRLNNAIWRAWHIQYINKKSPLVCQFVaNPLAD---DAHSL 227
Cdd:cd21771      1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFV-TPLEGseaDEHRK 79

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1126159208  228 PQAVVLEGKYWKRRMETVVKEYMKWRVYYKKK 259
Cdd:cd21771     80 PEAVVLEGNYWKRRIEVVMKEYHKWRIYYKKR 111
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 151-259 9.99e-56

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 188.73  E-value: 9.99e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  151 SIDASLTKLFECMTLAYNGKLVSPKWKTFKGLKLLWKDKIRLNNAIWRAWHIQYINKKSPLVCQFVaNPLAD----DAHS 226
Cdd:cd21772      1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFV-TPLDGsvdvDEHR 79

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1126159208  227 LPQAVVLEGKYWKRRMETVVKEYMKWRVYYKKK 259
Cdd:cd21772     80 RPEAIATEGKYWKRRIEIVIREYHKWRTYFKKR 112
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 995-1068 4.07e-40

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 142.41  E-value: 4.07e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  995 DQRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEI 1068
Cdd:cd11405      1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSLGQNPNQKVSKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 997-1068 1.45e-28

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 109.65  E-value: 1.45e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNvkISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEI 1068
Cdd:cd19688      3 RRMKHISAEQKRRFNIKICFDTLNSLVSTLKNSKP--ISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 994-1068 5.52e-28

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 108.13  E-value: 5.52e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1126159208  994 SDQRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEI 1068
Cdd:cd19689      2 TETRRITHISAEQKRRFNIKLGFDTLHSLVTTLSSQPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 996-1068 7.00e-17

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 76.31  E-value: 7.00e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQ---GNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEI 1068
Cdd:cd19687      1 RRREAHTQAEQKRRDAIKKGYDDLQDIVPTCQQQddiGSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRKEV 76
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 996-1075 7.58e-15

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 70.41  E-value: 7.58e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQgnvKISKAAMLQKTVDYTKKLQaerqqmlEEARVLKQEIEELNSAI 1075
Cdd:cd11404      1 QRRLNHVRSEKKRRELIKKGYDELCALVPGLDPQ---KRTKADILQKAADWIQELK-------EENEKLEEQLDELKEAA 70
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 997-1073 1.23e-12

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 64.49  E-value: 1.23e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGnvKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEELNS 1073
Cdd:cd11400      1 KRRLHNVLERQRRNDLKNSFEKLRDLVPELADNE--KASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75
HLH pfam00010
Helix-loop-helix DNA-binding domain;
997-1051 4.93e-12

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 61.71  E-value: 4.93e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQ 1051
Cdd:pfam00010    1 RREAHNERERRRRDRINDAFDELRELLPTLPP--DKKLSKAEILRLAIEYIKHLQ 53
bHLH_scINO4_like cd11403
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar ...
 996-1062 2.53e-11

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.


Pssm-ID: 381409  Cd Length: 71  Bit Score: 60.17  E-value: 2.53e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVkiSKAAMLQKTVDYTKKLQAERQQMLEEAR 1062
Cdd:cd11403      1 QKKENHISSEHKRREAIREGFDRLCAIVPALSSSQSR--SEAVVYVKTVEYLKELYERRAKLRSQLR 65
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 996-1068 3.27e-11

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 60.42  E-value: 3.27e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  996 QRRAiHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNV-------------KISKAAMLQKTVDYTKKLQAERQQMLEEAR 1062
Cdd:cd11395      3 KRLP-HNAIEKRYRSNLNTKIERLRDAIPSLRSPEGKsddgglgglapttKLSKATILTKAIEYIRHLEQENERLEEENE 81


                   ....*.
gi 1126159208 1063 VLKQEI 1068
Cdd:cd11395     82 ELRQQV 87
HLH smart00353
helix loop helix domain;
1004-1056 8.71e-11

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 58.38  E-value: 8.71e-11
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1126159208  1004 AEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQAERQQ 1056
Cdd:smart00353    3 RERRRRRKINEAFDELRSLLPTLPK--NKKLSKAEILRLAIEYIKSLQEELQK 53
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 997-1057 9.86e-11

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 58.48  E-value: 9.86e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQgnvKISKAAMLQKTVDYTKKLQAERQQM 1057
Cdd:cd11419      4 RREIANSNERRRMQSINAGFQSLRTLLPHCDGE---KLSKAAILQQTAEYIFSLEQEKTRL 61
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 995-1082 1.53e-10

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 58.89  E-value: 1.53e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  995 DQRRAIHISAEQKRRFNIKVGFDTLHTLIPTlssqGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEELNSA 1074
Cdd:cd11398      5 RQRRDNHKEVERRRRENINEGINELAALVPG----NAREKNKGAILARAVEYIQELQETEAKNIEKWTLEKLLTDQAIAE 80


                   ....*...
gi 1126159208 1075 ISNCQAQL 1082
Cdd:cd11398     81 LAALNEKL 88
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 997-1062 2.25e-10

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 57.36  E-value: 2.25e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLEEAR 1062
Cdd:cd11388      3 KKWKHVEAEKKRRNQIKKGFEDLINLINYPRNNNEKRISKSELLNKAVDDIRGLLKANEQLQEEIN 68
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 1005-1052 1.19e-09

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 54.83  E-value: 1.19e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1126159208 1005 EQKRRFNIKVGFDTLHTLIPTLSSQGnvKISKAAMLQKTVDYTKKLQA 1052
Cdd:cd00083      1 ERRRRDKINDAFEELKRLLPELPDSK--KLSKASILQKAVEYIRELQS 46
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 996-1075 1.53e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 53.13  E-value: 1.53e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTlSSQGNVKISKAAMLQKTVDYTKKLQAErQQMLEEARVLKQEIEELNSAI 1075
Cdd:cd18928     10 QKKDNHNLIERRRRFNINDRIKELGTLIPK-STDPEMRWNKGTILKASVDYIRKLQKE-QQRSKEIEMRQRKLEQANRSL 87
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
 996-1057 3.53e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 51.53  E-value: 3.53e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTlSSQGNVKISKAAMLQKTVDYTKKLQAERQQM 1057
Cdd:cd11397      4 QKKDNHNMIERRRRFNINDRIKELGTLLPK-SNDPDMRWNKGTILKASVDYIRKLQKEQERL 64
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 997-1071 2.03e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 49.27  E-value: 2.03e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPTLssQGNvKISKAAMLQKTVDYTkklqaerQQMLEEARVLKQEIEEL 1071
Cdd:cd11406      1 KRAHHNALERKRRDHIKDSFHSLRDSVPSL--QGE-KASRAQILKKATEYI-------QYMRRKNHTHQQDIDDL 65
bHLHzip_N-Myc_like cd11456
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, ...
 996-1071 6.04e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in N-Myc and similar proteins; N-Myc, also termed Class E basic helix-loop-helix protein 37 (bHLHe37), is a bHLHZip proto-oncogene protein that positively regulates the transcription of MYCNOS in neuroblastoma cells. It is also essential during embryonic development. N-Myc has a critical role in regulating the switch between proliferation and differentiation of progenitor cells. It binds DNA as a heterodimer with MAX. The family also includes S-Myc, encoded by rat or mouse intronless myc gene, which has apoptosis-inducing activity.


Pssm-ID: 381462 [Multi-domain]  Cd Length: 87  Bit Score: 48.36  E-value: 6.04e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEEL 1071
Cdd:cd11456      4 ERRRNHNILERQRRNDLRSSFLTLRDHVPELVK--NEKAAKVVILKKATEYVHSLQAEEQKLLLEKEKLQARQQQL 77
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 996-1071 6.41e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 48.93  E-value: 6.41e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTlSSQGNVKISKAAMLQKTVDYTKKLQAE---------RQQMLEEA-RVLK 1065
Cdd:cd18926     12 QKKDNHNLIERRRRFNINDRIKELGTLIPK-SNDPDMRWNKGTILKASVDYIRKLQREqqrakelenRQKKLEHAnRHLL 90


                   ....*.
gi 1126159208 1066 QEIEEL 1071
Cdd:cd18926     91 LRIQEL 96
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 1001-1059 1.42e-06

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 46.41  E-value: 1.42e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPTLSsqgnvKISKAAMLQKTVDYTKKLQaERQQMLE 1059
Cdd:cd11393      1 HSIAERKRREKINERIRALRSLVPNGG-----KTDKASILDEAIEYIKFLQ-EQVKVLS 53
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 998-1065 2.81e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 45.73  E-value: 2.81e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1126159208  998 RAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQgnvKISKAAMLQKTVDYTKKLQAERQQMLEEARVLK 1065
Cdd:cd19682      1 RLRHKKRERERRSELRELFDKLKQLLGLDSDE---KASKLAVLTEAIEEIQQLKREEDELQKEKARLT 65
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 998-1071 5.04e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 45.14  E-value: 5.04e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  998 RAIHISAEQKRRFNIKVGFDTLHTLIPtlsSQGNVKISKAAMLQKTVDYTKKLQaerqqmlEEARVLKQEIEEL 1071
Cdd:cd19690      1 RVSHKLAERKRRKEMKELFEDLRDALP---QERGTKASKWEILTKAISYIQQLK-------RHIRELRSEVNDL 64
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 1001-1053 5.09e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 44.94  E-value: 5.09e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPTLS-SQGNVKISKAAMLQKTVDYTKKLQAE 1053
Cdd:cd11387      2 HNAVERRRRDNINEKIQELGSLVPPSRlETKDLKPNKGSILSKAVEYIRELQNQ 55
bHLHzip_TFEB cd18927
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and ...
 996-1059 7.96e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EB (TFEB) and similar proteins; TFEB, also termed Class E basic helix-loop-helix protein 35 (bHLHe35), is a bHLHzip transcription factor that is required for vascularization of the mouse placenta. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF.


Pssm-ID: 381497  Cd Length: 91  Bit Score: 45.36  E-value: 7.96e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTlSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLE 1059
Cdd:cd18927     10 QKKDNHNLIERRRRFNINDRIKELGTLIPK-TNDLDVRWNKGTILKASVDYIKRMQKDLQRSRE 72
bHLHzip_c-Myc cd11458
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, ...
 994-1071 8.94e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in c-Myc and similar proteins; c-Myc, also termed Myc proto-oncogene protein, or Class E basic helix-loop-helix protein 39 (bHLHe39), or transcription factor p64, a bHLHZip proto-oncogene protein that functions as a transcription factor, which binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. It activates the transcription of growth-related genes.


Pssm-ID: 381464 [Multi-domain]  Cd Length: 84  Bit Score: 45.26  E-value: 8.94e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1126159208  994 SDQRRAiHISAEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEEL 1071
Cdd:cd11458      3 NDKRRT-HNVLERQRRNELKLSFFALRDQIPEVAN--NEKAPKVVILKKATEYILSMQADEQRLISEKEQLRRRREQL 77
bHLH-O_HERP_like cd11389
basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES) ...
 1001-1053 1.34e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy and enhancer of split (HES)-related repressor protein (HERP)-like family; The HERP-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split proteins. They contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. HERP proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this family. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression.


Pssm-ID: 381395 [Multi-domain]  Cd Length: 55  Bit Score: 43.46  E-value: 1.34e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPT-LSSQGNVKISKAAMLQKTVDYTKKLQAE 1053
Cdd:cd11389      1 HKVIEKRRRDRINESLAELRRLVPEaRKSKGSGKLEKAEILEMTLQHLKALQSS 54
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
 996-1051 1.40e-05

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 43.49  E-value: 1.40e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSqgnvKISKAAMLQKTVDYTKKLQ 1051
Cdd:cd19683      1 KSRERHNAKERQRRERIKIACDQLRKLVPGCSR----KTDKATVFEFTVAYIKFLR 52
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
 997-1060 1.54e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 44.00  E-value: 1.54e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  997 RRAIHISAEQKRRFNIKVGFDTLHTLIPtlssQGNVKISKAAMLQKTVDYTKKLQaERQQMLEE 1060
Cdd:cd11453      3 PRSKHSATEQRRRSKINERLQALRDLIP----HSDQKRDKASFLLEVIEYIQALQ-EKVAKLEE 61
bHLH_SOHLH1_2 cd18908
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
 1000-1052 1.85e-05

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation.


Pssm-ID: 381478 [Multi-domain]  Cd Length: 59  Bit Score: 43.48  E-value: 1.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1126159208 1000 IHISAEQKRRFNIKVGFDTLHTLIPTLSSqgnVKISKAAMLQKTVDYTKKLQA 1052
Cdd:cd18908      5 SHSLKERLRRERIKSSCDQLRDLLPYIKG---RKLDMASVLEMTVKYIRYIQE 54
bHLH-O_HEYL cd11447
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ...
 996-1052 2.80e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) and similar proteins; HEYL, also termed Class B basic helix-loop-helix protein 33 (bHLHb33), or hairy-related transcription factor 3 (HRT-3), is a bHLH-O transcriptional repressor that is strongly expressed in the presomitic mesoderm, the somites, the peripheral nervous system and smooth muscle of all arteries and is a downstream effector of the Notch and transforming growth factor-beta pathways. It promotes neuronal differentiation by activating proneural genes and inhibiting other hairy and enhancer of split (HES) and hairy/enhancer-of-split related with YRPW motif protein (HEY) proteins. HEYL also functions as a tumor suppressor involved in the progression of human cancers.


Pssm-ID: 381453 [Multi-domain]  Cd Length: 74  Bit Score: 43.55  E-value: 2.80e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1126159208  996 QRRAIhisAEQKRRFNIKVGFDTLHTLIPT-LSSQGNVKISKAAMLQKTVDYTKKLQA 1052
Cdd:cd11447     11 KRRGI---IEKRRRDRINSSLSELRRLVPTaFEKQGSSKLEKAEILQMTVDHLKMLHA 65
bHLH_AtPIF_like cd11445
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting ...
 999-1057 2.94e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana phytochrome interacting factors (PIFs) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as PIFs, ALC, PIL1, SPATULA, and UNE10. PIFs (PIF1, PIF3, PIF4, PIF5, PIF6 and PIF7) have been shown to control light-regulated gene expression. They directly bind to the photoactivated phytochromes and are degraded in response to light signals. ALC, also termed AtbHLH73, or protein ALCATRAZ, or EN 98, is required for the dehiscence of fruit, especially for the separation of the valve cells from the replum. It promotes the differentiation of a strip of labile non-lignified cells sandwiched between layers of lignified cells. PIL1, also termed AtbHLH124, or protein phytochrome interacting factor 3-like 1, or EN 110, is involved in responses to transient and long-term shade. It is required for the light-mediated inhibition of hypocotyl elongation and necessary for rapid light-induced expression of the photomorphogenesis- and circadian-related gene APRR9. PIL1 seems to play a role in multiple PHYB responses, such as flowering transition and petiole elongation. SPATULA, also termed AtbHLH24, or EN 99, plays a role in floral organogenesis. It promotes the growth of carpel margins and of pollen tract tissues derived from them. UNE10, also termed AtbHLH16, or protein UNFERTILIZED EMBRYO SAC 10, or EN 99, is required during the fertilization of ovules by pollen.


Pssm-ID: 381451  Cd Length: 64  Bit Score: 43.13  E-value: 2.94e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1126159208  999 AIHISAEQKRRFNIKVGFDTLHTLIPTLSsqgnvKISKAAMLQKTVDYTKKLQAERQQM 1057
Cdd:cd11445      4 EVHNLSERRRRDRINEKMKALQELIPNCN-----KTDKASMLDEAIEYLKSLQLQVQMM 57
bHLHzip_L-Myc cd11457
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, ...
 995-1079 3.04e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in L-Myc and similar proteins; L-Myc, also termed Class E basic helix-loop-helix protein 38 (bHLHe38), or protein L-Myc-1, or V-myc myelocytomatosis viral oncogene homolog, is a bHLHZip oncoprotein belonging to the Myc oncogene protein family. It binds DNA as a heterodimer with MAX. L-Myc is co-expressed with another Myc family member and has weaker transformation/transactivation activities. L-Myc knockout mouse did not exhibit any phenotypic abnormalities.


Pssm-ID: 381463 [Multi-domain]  Cd Length: 89  Bit Score: 43.63  E-value: 3.04e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  995 DQRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSqgNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEELNSA 1074
Cdd:cd11457      5 VAKRKNHNFLERKRRNDLRSRFLALRDEVPGLAS--CSKTPKVVILSKATEYLRGLVSAERRMAAEKRQLKSRQQQLLRR 82


                   ....*
gi 1126159208 1075 ISNCQ 1079
Cdd:cd11457     83 IAQLK 87
bHLHzip_TFEC cd18925
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and ...
 996-1072 3.46e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor EC (TFEC) and similar proteins; TFEC, also termed Class E basic helix-loop-helix protein 34 (bHLHe34), or transcription factor EC-like (TFEC-L), is a bHLHzip transcriptional regulator that acts as a repressor or an activator and regulates gene expression in macrophages. It plays an important role in the niche to expand hematopoietic progenitors through the modulation of several cytokines.


Pssm-ID: 381495  Cd Length: 85  Bit Score: 43.53  E-value: 3.46e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIPTlSSQGNVKISKAAMLQKTVDYTKKLQAERQQMLE-EARvlKQEIEELN 1072
Cdd:cd18925      4 QKKDNHNLIERRRRYNINYRIKELGTLIPK-SNDPDMRWNKGTILKASVEYIKWLQKEQQRARElEHR--QKKLEQAN 78
bHLHzip_SREBP cd11394
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 996-1065 3.90e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box.


Pssm-ID: 381400 [Multi-domain]  Cd Length: 73  Bit Score: 43.03  E-value: 3.90e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  996 QRRAIHISAEQKRRFNIKVGFDTLHTLIptlsSQGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLK 1065
Cdd:cd11394      5 EKRSAHNAIEKRYRSSINDRIIELKDLV----VGPDAKMNKSAVLRKAIDYIRYLQKVNQKLKQENMALK 70
bHLH-O_HEY1 cd19748
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ...
 996-1052 5.06e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1) and similar proteins; HEY1, also termed cardiovascular helix-loop-helix factor 2 (CHF-2), or Class B basic helix-loop-helix protein 31 (bHLHb31), or HES-related repressor protein 1, or hairy and enhancer of split-related protein 1 (HESR-1), or hairy-related transcription factor 1 (HRT-1), is a bHLH-O transcriptional repressor that acts as an essential downstream effector of the Notch signaling pathway and may play a fundamental role in vascular development. HEY1 also participates several cancer-related pathways. It acts as a positive regulator of the tumor suppressor p53.


Pssm-ID: 381591 [Multi-domain]  Cd Length: 71  Bit Score: 42.63  E-value: 5.06e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1126159208  996 QRRAIhisAEQKRRFNIKVGFDTLHTLIPT-LSSQGNVKISKAAMLQKTVDYTKKLQA 1052
Cdd:cd19748     11 RRRGI---IEKRRRDRINNSLSELRRLVPSaFEKQGSAKLEKAEILQMTVDHLKMLHA 65
bHLH-O_HEY2 cd18920
basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with ...
 996-1052 8.53e-05

basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) and similar proteins; HEY2, also termed cardiovascular helix-loop-helix factor 1 (CHF-1), or Class B basic helix-loop-helix protein 32 (bHLHb32), or HES-related repressor protein 2, or hairy and enhancer of split-related protein 2 (HESR-2), or hairy-related transcription factor 2 (HRT-2), or protein gridlock homolog, is a bHLH-O transcriptional repressor expressed preferentially in the developing and adult cardiovascular system. As a downstream effector of Notch signaling, HEY2 may be required for cardiovascular development. It also plays an important role in neurologic development, as well as in the progression of human cancers.


Pssm-ID: 381490 [Multi-domain]  Cd Length: 82  Bit Score: 42.43  E-value: 8.53e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1126159208  996 QRRAIhisAEQKRRFNIKVGFDTLHTLIPT-LSSQGNVKISKAAMLQKTVDYTKKLQA 1052
Cdd:cd18920     12 KRRGI---IEKRRRDRINNSLSELRRLVPTaFEKQGSAKLEKAEILQMTVDHLKMLQA 66
bHLH_AtAIG1_like cd11455
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar ...
 1000-1059 9.98e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein AIG1 and similar proteins; AIG1, also termed AtbHLH32, or EN 54, or protein target of MOOPTEROS 5, is a transcription factor required for MONOPTEROS-dependent root initiation in embryo.


Pssm-ID: 381461  Cd Length: 80  Bit Score: 41.90  E-value: 9.98e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208 1000 IHISAEQKRRFNIKVGFDTLHTLIPtlssqGNVKISKAAMLQKTVDYTKKLqaeRQQMLE 1059
Cdd:cd11455     10 SHSEAERRRRERINSHLATLRTLLP-----NLSKTDKASLLAEVVQHVKEL---KRQAAE 61
bHLH-O_HERP_HES cd19685
basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like ...
 1005-1053 1.01e-04

basic helix-loop-helix-orange (bHLH-O) domain found in HERP/HES-like family; The HERP/HES-like family includes bHLH-O transcriptional regulators that are related to the Drosophila hairy and Enhancer-of-split (HES) proteins. The HERP (HES-related repressor protein) subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant glycine residue in its basic region, an orange domain in the central region and YXXW sequence motif at its C-terminal region. Hairy and enhancer of split (HES)-related repressor protein (HERP) proteins (HEY1, HEY2 and HEYL) act as downstream effectors of Notch signaling. They are involved in cardiovascular development and have roles in somitogenesis, myogenesis and gliogenesis. Hairy and enhancer of split-related protein HELT is a transcriptional repressor expressed in the developing central nervous system. It binds preferentially to the canonical E box sequence 5'-CACGCG-3' and regulates neuronal differentiation and/or identity. Differentially expressed in chondrocytes proteins, DEC1 and DEC2, are widely expressed in both embryonic and adult tissues and have been implicated in apoptosis, cell proliferation, and circadian rhythms, as well as malignancy in various cancers. Drosophila melanogaster protein clockwork orange (Cwo) is also included in this subfamily. It is involved in the regulation of Drosophila circadian rhythms. It functions as both an activator and a repressor of clock gene expression. The HES subfamily proteins contain a basic helix-loop-helix (bHLH) domain with an invariant proline residue in its basic region, an orange domain in the central region and a conserved tetrapeptide motif, WRPW, at its C-terminal region. They form heterodimers or homodimers via their HLH domain and bind DNA to repress gene transcription that play an essential role in development of both compartment and boundary cells of the central nervous system.


Pssm-ID: 381528 [Multi-domain]  Cd Length: 52  Bit Score: 40.87  E-value: 1.01e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1126159208 1005 EQKRRFNIKVGFDTLHTLIP-TLSSQGNVKISKAAMLQKTVDYTKKLQAE 1053
Cdd:cd19685      2 EKRRRQRINDKLNQLKELLPpNLSKQSRSKLSKAEILEMAITELRRLQQE 51
bHLH_AtTT8_like cd11451
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 ...
 1001-1062 2.23e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein transparent testa 8 (TT8) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as TT8, EGL1, and GL3. TT8, also termed AtbHLH42, or EN 32, is involved in the control of flavonoid pigmentation and plays a key role in regulating leucoanthocyanidin reductase (BANYULS) and dihydroflavonol-4-reductase (DFR). EGL1, also termed AtbHLH2, or EN 30, or AtMYC146, or protein enhancer of GLABRA 3, is involved in epidermal cell fate specification and regulates negatively stomata formation but promotes trichome formation. GL3, also termed AtbHLH1, or AtMYC6, or protein shapeshifter, or EN 31, is involved in epidermal cell fate specification. It regulates negatively stomata formation, but, in association with TTG1 and MYB0/GL1, promotes trichome formation, branching and endoreplication.


Pssm-ID: 381457  Cd Length: 75  Bit Score: 40.87  E-value: 2.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPTLSsqgnvKISKAAMLQKTVDYTKKLQaERQQMLEEAR 1062
Cdd:cd11451      6 HAMAERRRREKLNERFITLRSMVPFVT-----KMDKVSILGDAIEYLKQLQ-RRVEELESRR 61
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
 998-1071 3.15e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 40.38  E-value: 3.15e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  998 RAIHISAEQKRRFNIKVGFDTLHTLIPTLssqGNVKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEEL 1071
Cdd:cd11402      3 REVHNKLEKNRRAHLKECFETLKRQIPNL---DDKKTSNLNILRSALRYIQILKRKEKEYEHEMERLAREKIAL 73
bHLH_AtNAI1_like cd11452
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar ...
 1001-1065 3.21e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein NAI1 and similar proteins; NAI1, also termed AtbHLH20, or EN 27, is a bHLH transcription activator that regulates the expression of at least NAI2, PYK10 and PBP1. It is required for and mediates the formation of endoplasmic reticulum bodies (ER bodies). It plays a role in the symbiotic interactions with the endophytes of the Sebacinaceae fungus family, such as Piriformospora indica and Sebacina.


Pssm-ID: 381458 [Multi-domain]  Cd Length: 75  Bit Score: 40.52  E-value: 3.21e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPTLSsqgnvKISKAAMLQKTVDYTKKLQaERQQMLEEARVLK 1065
Cdd:cd11452      6 HILAERKRREKLSQRFIALSALVPGLK-----KMDKASVLGDAIKHIKQLQ-ERVKELEEEKKEK 64
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 514-929 3.23e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.91  E-value: 3.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  514 ISVLAQNTRPTQPPHIHSSQPASMSTSTQQVSQVIAAPTPITPSSTAHQQPPTMLPMYQAQPNI---------PVMPSTQ 584
Cdd:pfam05109  405 ITRTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVstadvtsptPAGTTSG 484

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  585 TAFQTPTSSPQPNVAPFGFPQQQQQKTQTIQPMPalqqqqqqqivsqgnyagfTTVSTLPASTfmetddqqqqqhqqQQQ 664
Cdd:pfam05109  485 ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTP-------------------NATSPTPAVT--------------TPT 531

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  665 QQQPAPTRSRTTPKQypLAPKPAPSATIQQGALGFTTQNAMQVAFTQNSLQQGVNSNTvqfikPKGLSPIAPKPSTTASQ 744
Cdd:pfam05109  532 PNATSPTLGKTSPTS--AVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPT-----PNATSPTVGETSPQANT 604

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  745 TATILTASVGSPqgVGGSGDKTHTVSVqntflaqlltggsgaftTQGIQPCTSAGTSTMSNQVYLTSSAIKPDTSLLNTV 824
Cdd:pfam05109  605 TNHTLGGTSSTP--VVTSPPKNATSAV-----------------TTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTS 665

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  825 VTPSTTqgfvlAANPS---QLAQSPQPTTATYQekvagVTDFQSSVLVAAAAQAGKVGlpglATATKVERKSPPVACSTP 901
Cdd:pfam05109  666 HMPLLT-----SAHPTggeNITQVTPASTSTHH-----VSTSSPAPRPGTTSQASGPG----NSSTSTKPGEVNVTKGTP 731

                          410       420       430
                   ....*....|....*....|....*....|.
gi 1126159208  902 IKPASTPNSPSA---ASPITTEDSPGHNSET 929
Cdd:pfam05109  732 PKNATSPQAPSGqktAVPTVTSTGGKANSTT 762
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 498-929 3.47e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.14  E-value: 3.47e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  498 SSPIQMDTNQTSLEDAISVLAQNTRPTQPPHIHSSQPASMSTS---TQQVSQVIAAPTPITPSSTAHQQPPTMLPMYQAQ 574
Cdd:pfam03154  143 STSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSpppPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  575 PNIP---VMPSTQTAFQTPTSSPQPNVAPFGFPQQQQQKTQTIQPMPALQqqqqqqivsqgnyagfTTVSTLPASTfmet 651
Cdd:pfam03154  223 STAAphtLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLH----------------GQMPPMPHSL---- 282

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  652 ddQQQQQHQQQQQQQQPAPTRSRTTPKQYPLAPKPAPSATIQQGALGFTTQNAMQVAFTQNSLQQGVNSNTVQFIKPKGL 731
Cdd:pfam03154  283 --QTGPSHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPT 360

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  732 SPIAPKPSTTASQTATILT--------ASVGSPQGVGG-SGDKTHTVSVQNTFLAQLLTGGsgafttQGIQPCTSAGTST 802
Cdd:pfam03154  361 TPIPQLPNPQSHKHPPHLSgpspfqmnSNLPPPPALKPlSSLSTHHPPSAHPPPLQLMPQS------QQLPPPPAQPPVL 434

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  803 MSNQVYLTSSAIKPDTSLLNTVVT--PSTTQGFVLAANPSQLAQSPQPTTATyqekvAGVTDFQSSVLVAAAAQAGKVGL 880
Cdd:pfam03154  435 TQSQSLPPPAASHPPTSGLHQVPSqsPFPQHPFVPGGPPPITPPSGPPTSTS-----SAMPGIQPPSSASVSSSGPVPAA 509

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*....
gi 1126159208  881 PGLATATKVERKSPPVACSTPIKPASTPNSPSaaSPITTEDSPGHNSET 929
Cdd:pfam03154  510 VSCPLPPVQIKEEALDEAEEPESPPPPPRSPS--PEPTVVNTPSHASQS 556
bHLHzip_USF2 cd18923
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) ...
 995-1071 3.66e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in upstream stimulatory factor 2 (USF2) and similar proteins; USF2, also termed Class B basic helix-loop-helix protein 12 (bHLHb12), or major late transcription factor 2, or FOS-interacting protein (FIP), or upstream transcription factor 2, is a bHLHzip transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters.


Pssm-ID: 381493  Cd Length: 80  Bit Score: 40.45  E-value: 3.66e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1126159208  995 DQRRAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQgNVKI--SKAAMLQKTVDYTKKLQAERQQMLEEARvlkqEIEEL 1071
Cdd:cd18923      6 ERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNTD-NSKTgaSKGGILSKACDYIRELRQTNQRMQETYK----EAERL 79
PHA03247 PHA03247
large tegument protein UL36; Provisional
 458-931 1.06e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 1.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  458 PPEER-PSASATVSSPPFQNQMSADTMQYQGRSQAGM----SYQESSPIQMDTNQTSLEDAISVLAQNTRPTQPPHIHSS 532
Cdd:PHA03247  2483 PAEARfPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAIlpdePVGEPVHPRMLTWIRGLEELASDDAGDPPPPLPPAAPPA 2562

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  533 QPasmstsTQQVSQVIAAPTPITPSSTAHQQPPTMlPMYQAQPNIPVMPSTQTAFQTPTSSPQPNVAPFGFPQQQQQKTQ 612
Cdd:PHA03247  2563 AP------DRSVPPPRPAPRPSEPAVTSRARRPDA-PPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  613 TIQPMPALQQQQQQQIVSQGNYAGFTTVSTLPASTFMETDDQQQQQHQQQQQQQQP-APTRSRTTPKQYPLAPKPAPSAT 691
Cdd:PHA03247  2636 NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPPPPPTPEPAPHAL 2715

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  692 IQQGALGFTTQNAMQVAftqnslqqgvnsntvqfiKPKGLSPIAPKPSTTASQTATIltASVGSPQGVGGSGDKTHTvsv 771
Cdd:PHA03247  2716 VSATPLPPGPAAARQAS------------------PALPAAPAPPAVPAGPATPGGP--ARPARPPTTAGPPAPAPP--- 2772

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  772 qntflAQLLTGGSGAFTTQGIQPCTSAGTSTMS-NQVYLTSSAIKPDTSLLNTVVTPSTTQGFVLAANP--SQLAQSPQP 848
Cdd:PHA03247  2773 -----AAPAAGPPRRLTRPAVASLSESRESLPSpWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPtaPPPPPGPPP 2847

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  849 TTATYQEKVAGVTDF------QSSVLVAAAA---QAGKVGLPGLATATK--------VERKSPPVAcstPIKPASTPNSP 911
Cdd:PHA03247  2848 PSLPLGGSVAPGGDVrrrppsRSPAAKPAAParpPVRRLARPAVSRSTEsfalppdqPERPPQPQA---PPPPQPQPQPP 2924

                          490       500
                   ....*....|....*....|
gi 1126159208  912 SAASPITTEDSPGHNSETLA 931
Cdd:PHA03247  2925 PPPQPQPPPPPPPRPQPPLA 2944
bHLH_AtMYC1_like cd18918
basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; ...
 1005-1062 1.12e-03

basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins; MYC1, also termed AtbHLH12, or EN 58, acts as a transcription activator, when associated with MYB75/PAP1 or MYB90/PAP2.


Pssm-ID: 381488 [Multi-domain]  Cd Length: 70  Bit Score: 38.85  E-value: 1.12e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1126159208 1005 EQKRRFNIKVGFDTLHTLIPTLSsqgnvKISKAAMLQKTVDYTKKLQA---ERQQMLEEAR 1062
Cdd:cd18918      5 ERERREKLNEKFSDLRNLIPNPT-----KNDRASILSDAIKYINELQRtveELKSLVEKKR 60
PRK10927 PRK10927
cell division protein FtsN;
456-600 1.67e-03

cell division protein FtsN;


Pssm-ID: 236797 [Multi-domain]  Cd Length: 319  Bit Score: 41.97  E-value: 1.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126159208  456 VVPPEErPSASATVSSPpfqNQMSADTMQYQGRSQAGMSYQESSPIQMDTNQTSLEDAISVLA--------QNTRPTQPP 527
Cdd:PRK10927    96 VRAPTE-PSAGGEVKTP---EQLTPEQRQLLEQMQADMRQQPTQLVEVPWNEQTPEQRQQTLQrqrqaqqlAEQQRLAQQ 171

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126159208  528 HIHSSQPASMSTSTQQVSQVIAAPTPitPSSTAHQQPptmlpmYQAQPNIPVMPSTQTAFQTPTSSPQPNVAP 600
Cdd:PRK10927   172 SRTTEQSWQQQTRTSQAAPVQAQPRQ--SKPASTQQP------YQDLLQTPAHTTAQSKPQQAAPVTRAADAP 236
bHLH_AtAIB_like cd11449
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE ...
 1001-1073 2.39e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins; The family includes several bHLH transcription factors from Arabidopsis thaliana, such as AIB and MYC proteins (MYC2, MYC3 and MYC4). AIB, also termed AtbHLH17, or EN 35, is a transcription activator that regulates positively abscisic acid (ABA) response. MYC2, also termed protein jasmonate insensitive 1, or R-homologous Arabidopsis protein 1 (RAP-1), or AtbHLH6, or EN 38, or Z-box binding factor 1 protein, is a transcriptional activator involved in abscisic acid (ABA), jasmonic acid (JA), and light signaling pathways. MYC3, also termed protein altered tryptophan regulation 2, or AtbHLH5, or transcription factor ATR2, or EN 36, is a transcription factor involved in tryptophan, jasmonic acid (JA) and other stress-responsive gene regulation. MYC4, also termed AtbHLH4, or EN 37, is a transcription factor involved in jasmonic acid (JA) gene regulation. MYC2, together with MYC3 and MYC4, controls additively subsets of JA-dependent responses.


Pssm-ID: 381455 [Multi-domain]  Cd Length: 78  Bit Score: 38.14  E-value: 2.39e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPTLSsqgnvKISKAAMLQKTVDYTKKLQAERQQMLEEARVLKQEIEELNS 1073
Cdd:cd11449      9 HVEAERQRREKLNQRFYALRAVVPNVS-----KMDKASLLGDAISYINELKSKVQDMETEKKEMKRQESEKKT 76
bHLH_PAS cd11391
basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found ...
 998-1051 4.44e-03

basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain family; bHLH-PAS domain has been found in a large group of bHLH transcription regulators that are involved in gene expression responding to environmental change and controlling aspects of neural development, including proteins from aryl hydrocarbon receptor nuclear translocator (ARNT) family, hypoxia-inducible factor (HIF) family, aryl hydrocarbon receptor (AhR) family, neuronal PAS domain-containing protein (NPAS) family, Circadian locomotor output cycles protein kaput (CLOCK)-like family, and single-minded (SIM) family. bHLH-PAS transcriptional regulatory factors have a bHLH DNA-binding domain followed by two PAS domains and a C-terminal activation or repression domain. bHLH-PAS family members can be divided into class I and class II based on their dimerization partner. bHLH-PAS class I factors include AhR, HIF and SIM. The best characterized bHLH-PAS Class II protein is the ubiquitous ARNT. Some members of bHLH-PAS family act as transcriptional coactivators (such as NCoA) that lack the ability to dimerize and bind DNA.


Pssm-ID: 381397 [Multi-domain]  Cd Length: 55  Bit Score: 36.40  E-value: 4.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1126159208  998 RAIHISAEQKRRFNIKVGFDTLHTLIPTLSSQGNvKISKAAMLQKTVDYTKKLQ 1051
Cdd:cd11391      1 REKSREAAKKRRDKENAEISELASLLPLPPAVGS-KLDKLSVLRLAVAYLRLKK 53
bHLH_AtMEE8_like cd19698
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein maternal effect ...
 1001-1057 7.36e-03

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein maternal effect embryo arrest 8 (AtMEE8) and similar proteins; AtMEE8, also termed AtbHLH108, or EN 132, is a bHLH transcription factor required during early embryo development, for the endosperm formation.


Pssm-ID: 381541  Cd Length: 71  Bit Score: 36.27  E-value: 7.36e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1126159208 1001 HISAEQKRRFNIKVGFDTLHTLIPTLSSQGNVkiskAAMLQKTVDYTKKLQAERQQM 1057
Cdd:cd19698      1 HNLLEKKRRERIKDKIEILKGLTPNCTPKSDI----ASILSCVIDYIKSLLLQVEKL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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