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Conserved domains on  [gi|1040664609|ref|XP_017206667|]
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zinc finger protein 345 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-374 4.70e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 205 SSRRKKDKPFSCEHCKRTFESPILLKAHQ--VVHV-KSEKTFIC--SQCGRRFGSKDTLDVHYQLHTDNSPYVC--NKCG 277
Cdd:COG5048   281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSgESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSS 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 278 KIFT-----EHKQLQSHQRVHNEDRTFICKV--CGKSFNQAYGLRKHLVVHSTEKVH--KCDVCGKSFHFRNNLLRHQRI 348
Cdd:COG5048   361 SKFSpllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKI 440

                         170       180
                  ....*....|....*....|....*.
gi 1040664609 349 HTGEKPFTCQTCGRSFNQLDTLKAHK 374
Cdd:COG5048   441 HTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-597 2.98e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 325 KVHKCDVCGKSFHFRNNLLRHQRIHTGEKPFTCQTCGR--SFNQLDTLKAHKLTHTGERP-------------------- 382
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSdlnskslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 383 -------YKCKMCNKGFVQKQILRLHEGEHEGEGGYSCFICDMLVGCKNSLQTHLAVHEGQTPVVC--------LVCGES 447
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSkdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 448 IVSTLKSHQHNALKTQQYKAmklrqhNALTSQQRKHTITTKFSCSLCGKFC------RSFAGLNLHKMIHTGEKPYSCSE 521
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI------PSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 522 CGKPFRQKNSLKTHQTLHTGER-PFSCVECRKSFHTLANLRRHER--IHTGE--KPFKCGI--CERKFNQSNSLKAHMHI 594
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                  ...
gi 1040664609 595 HTG 597
Cdd:COG5048   346 HTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
587-612 1.21e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 587 SLKAHMHIHTGEKQYVCDKCGKSFAY 612
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-374 4.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 205 SSRRKKDKPFSCEHCKRTFESPILLKAHQ--VVHV-KSEKTFIC--SQCGRRFGSKDTLDVHYQLHTDNSPYVC--NKCG 277
Cdd:COG5048   281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSgESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSS 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 278 KIFT-----EHKQLQSHQRVHNEDRTFICKV--CGKSFNQAYGLRKHLVVHSTEKVH--KCDVCGKSFHFRNNLLRHQRI 348
Cdd:COG5048   361 SKFSpllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKI 440

                         170       180
                  ....*....|....*....|....*.
gi 1040664609 349 HTGEKPFTCQTCGRSFNQLDTLKAHK 374
Cdd:COG5048   441 HTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-597 2.98e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 325 KVHKCDVCGKSFHFRNNLLRHQRIHTGEKPFTCQTCGR--SFNQLDTLKAHKLTHTGERP-------------------- 382
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSdlnskslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 383 -------YKCKMCNKGFVQKQILRLHEGEHEGEGGYSCFICDMLVGCKNSLQTHLAVHEGQTPVVC--------LVCGES 447
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSkdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 448 IVSTLKSHQHNALKTQQYKAmklrqhNALTSQQRKHTITTKFSCSLCGKFC------RSFAGLNLHKMIHTGEKPYSCSE 521
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI------PSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 522 CGKPFRQKNSLKTHQTLHTGER-PFSCVECRKSFHTLANLRRHER--IHTGE--KPFKCGI--CERKFNQSNSLKAHMHI 594
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                  ...
gi 1040664609 595 HTG 597
Cdd:COG5048   346 HTS 348
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 273-328 7.18e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 7.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1040664609 273 CNKCGKIFTEHKQLQSHQRvhneDRTFICKVCGKSFNQAYGLRKHLvvhstEKVHK 328
Cdd:cd20908     4 CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC-----LQVHK 50
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-584 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 559 NLRRHERIHTGEKPFKCGICERKFNQ 584
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 1.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 341 NLLRHQRIHTGEKPFTCQTCGRSFNQ 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
587-612 1.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 587 SLKAHMHIHTGEKQYVCDKCGKSFAY 612
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
205-374 4.70e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 4.70e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 205 SSRRKKDKPFSCEHCKRTFESPILLKAHQ--VVHV-KSEKTFIC--SQCGRRFGSKDTLDVHYQLHTDNSPYVC--NKCG 277
Cdd:COG5048   281 SSEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSgESLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSS 360

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 278 KIFT-----EHKQLQSHQRVHNEDRTFICKV--CGKSFNQAYGLRKHLVVHSTEKVH--KCDVCGKSFHFRNNLLRHQRI 348
Cdd:COG5048   361 SKFSpllnnEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKI 440

                         170       180
                  ....*....|....*....|....*.
gi 1040664609 349 HTGEKPFTCQTCGRSFNQLDTLKAHK 374
Cdd:COG5048   441 HTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
325-597 2.98e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 2.98e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 325 KVHKCDVCGKSFHFRNNLLRHQRIHTGEKPFTCQTCGR--SFNQLDTLKAHKLTHTGERP-------------------- 382
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSdlnskslplsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 383 -------YKCKMCNKGFVQKQILRLHEGEHEGEGGYSCFICDMLVGCKNSLQTHLAVHEGQTPVVC--------LVCGES 447
Cdd:COG5048   112 ssssnsnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSkdpssnlsLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 448 IVSTLKSHQHNALKTQQYKAmklrqhNALTSQQRKHTITTKFSCSLCGKFC------RSFAGLNLHKMIHTGEKPYSCSE 521
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSI------PSSSSDQNLENSSSSLPLTTNSQLSpksllsQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 522 CGKPFRQKNSLKTHQTLHTGER-PFSCVECRKSFHTLANLRRHER--IHTGE--KPFKCGI--CERKFNQSNSLKAHMHI 594
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345


                  ...
gi 1040664609 595 HTG 597
Cdd:COG5048   346 HTS 348
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 273-328 7.18e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.39  E-value: 7.18e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1040664609 273 CNKCGKIFTEHKQLQSHQRvhneDRTFICKVCGKSFNQAYGLRKHLvvhstEKVHK 328
Cdd:cd20908     4 CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC-----LQVHK 50
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 569-620 9.46e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.09  E-value: 9.46e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1040664609 569 GEKPFKCGI--CERKFNQSNSLKAHM-HIHTGE------------------KQYVCDKCGKSFAYLRNLKSHK 620
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQklhenpspekmnifsakdKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
559-584 1.07e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.07e-04
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 559 NLRRHERIHTGEKPFKCGICERKFNQ 584
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-509 1.76e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 264 LHTDNSPYVCNKCGKIFTEHKQLQSHQRVHNEDRTFICKVCGKSFNQAYGLRKHLVVHSTE-------KVHKCDVCGKSF 336
Cdd:COG5048   220 LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISF 299

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 337 HFRNNLLRHQR--IHTGE--KPFTC--QTCGRSFNQLDTLKAHKLTHTGERPYKCKMCNKGFVQKQIL----RLHEGEHE 406
Cdd:COG5048   300 SRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYK 379

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 407 GEGGYSCFICDMLVGCKNSLQTHLAvhegQTPVVCLVCGESivstlkSHQHNALKTQQYKAmklrqHNALTSQQRKHTIT 486
Cdd:COG5048   380 DLKNDKKSETLSNSCIRNFKRDSNL----SLHIITHLSFRP------YNCKNPPCSKSFNR-----HYNLIPHKKIHTNH 444

                         250       260
                  ....*....|....*....|...
gi 1040664609 487 TKFSCSLCGKFCRSFAGLNLHKM 509
Cdd:COG5048   445 APLLCSILKSFRRDLDLSNHGKD 467
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 1.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 341 NLLRHQRIHTGEKPFTCQTCGRSFNQ 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 513-595 1.88e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 513 GEKPYSCS--ECGKPFRQKNSLKTHQtLHTgerpfscvECRKSFHTLANLRRHERIHTGEKPFKCGICERKFNQSNSLKA 590
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1040664609 591 HM-HIH 595
Cdd:COG5189   417 HRkHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-620 5.91e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 5.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 209 KKDKPFSCEHCKRTFESPILLKAHQVVHvKSEKTFICSQCGR--RFGSKDTLDVHYQLHTDNSPYVCNK----------- 275
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSH-TGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKslplsnskass 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 276 -----CGKIFTEHKQLQSHQRVHNEDRTFICKVCGKSFNQAYGLRKHL-----VVHSTEKVHKCDV--CGKSFHFRNNLL 343
Cdd:COG5048   108 sslssSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNsssvnTPQSNSLHPPLPAnsLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 344 RHQRIHTGEKPFTCQTCGRSFNQLDTLKAHKLTHTGERPYKCKMCNkGFVQKQILRlhegehegeggyscficdmlvgck 423
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS-QLSPKSLLS------------------------ 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 424 nslQTHLAVHEGQTPVVCLVCGESIVSTLKSHQHNalktqqykamklrqHNALTSQQRKhTITTKFSCSLCGKfCRSFAG 503
Cdd:COG5048   243 ---QSPSSLSSSDSSSSASESPRSSLPTASSQSSS--------------PNESDSSSEK-GFSLPIKSKQCNI-SFSRSS 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1040664609 504 LNLHKM---IHTGE--KPYSCSE--CGKPFRQKNSLKTHQTLHTGERPFSCV--ECRKSFHTLANLRRHERIH------- 567
Cdd:COG5048   304 PLTRHLrsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlkn 383

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1040664609 568 ----TGEKPFKCGICERKFNQSNSLkaHMHIHTGEKQYVCDKCGKSFAYLRNLKSHK 620
Cdd:COG5048   384 dkksETLSNSCIRNFKRDSNLSLHI--ITHLSFRPYNCKNPPCSKSFNRHYNLIPHK 438
zf-H2C2_2 pfam13465
Zinc-finger double domain;
587-612 1.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 1040664609 587 SLKAHMHIHTGEKQYVCDKCGKSFAY 612
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 212-265 3.41e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.77  E-value: 3.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1040664609 212 KPFsCEHCKRTFESPILLKAHQvvhvKSeKTFICSQCGRRFGSKDTLDVH-YQLH 265
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQ----KA-KHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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