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Conserved domains on  [gi|1039779190|ref|XP_017177834|]
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X-ray radiation resistance-associated protein 1 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-280 2.29e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 120 KDFKHFTSVIYINASENL---LPLDVFHtFPVLKELELAFNGIKMVYVKYGDFKTLEFLDLSFNSLTE--EAICDLgilP 194
Cdd:COG4886   107 EELSNLTNLESLDLSGNQltdLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDlpEELGNL---T 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 195 HLRVLLLTGNGLTSLPPNMAvkeqeasmtsltskkyilRFPALETLMLDDNKLSNPScfASLAGLRRLKKLSLDQNKIVR 274
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLG------------------NLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD 242


                  ....*.
gi 1039779190 275 IPYLQQ 280
Cdd:COG4886   243 LPELGN 248
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
239-423 5.51e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 5.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 239 TLMLDDNKLSnpSCFASLAGlrRLKKLSLDQNKIVRIPYL--QQIQLRDGSGDWVTEGPNPQKELQPQMWIFET-----P 311
Cdd:PRK15370  203 TLILDNNELK--SLPENLQG--NIKTLYANSNQLTSIPATlpDTIQEMELSINRITELPERLPSALQSLDLFHNkisclP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 312 DEQP-----------NYTVLPMKKDVDRTEVVFssypgFSTSETAKVCSLPPMFEILPV--KSLKARNQTLAPpfpELRY 378
Cdd:PRK15370  279 ENLPeelrylsvydnSIRTLPAHLPSGITHLNV-----QSNSLTALPETLPPGLKTLEAgeNALTSLPASLPP---ELQV 350

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1039779190 379 LSLAYNKIAkedaVLPAALFPSLCELVFHNNPLVAHTRGIPPLLK 423
Cdd:PRK15370  351 LDVSKNQIT----VLPETLPPTITTLDVSRNALTNLPENLPAALQ 391
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-280 2.29e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 120 KDFKHFTSVIYINASENL---LPLDVFHtFPVLKELELAFNGIKMVYVKYGDFKTLEFLDLSFNSLTE--EAICDLgilP 194
Cdd:COG4886   107 EELSNLTNLESLDLSGNQltdLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDlpEELGNL---T 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 195 HLRVLLLTGNGLTSLPPNMAvkeqeasmtsltskkyilRFPALETLMLDDNKLSNPScfASLAGLRRLKKLSLDQNKIVR 274
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLG------------------NLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD 242


                  ....*.
gi 1039779190 275 IPYLQQ 280
Cdd:COG4886   243 LPELGN 248
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-277 4.67e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 4.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 102 SDLCTINVSGMKFSKAKEKDFKHFTSVIYINASENLL----PLDVFHTFPVLKELELAFNGIKMVyVKYGDFKTLEFLDL 177
Cdd:PLN00113   69 SRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLsgpiPDDIFTTSSSLRYLNLSNNNFTGS-IPRGSIPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 178 SFNSLTEEAICDLGILPHLRVLLLTGNGLTSLPPNmavkeqeaSMTSLTSkkyilrfpaLETLMLDDNKLSNpSCFASLA 257
Cdd:PLN00113  148 SNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPN--------SLTNLTS---------LEFLTLASNQLVG-QIPRELG 209

                         170       180
                  ....*....|....*....|.
gi 1039779190 258 GLRRLKKLSLDQNKIV-RIPY 277
Cdd:PLN00113  210 QMKSLKWIYLGYNNLSgEIPY 230
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
239-423 5.51e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 5.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 239 TLMLDDNKLSnpSCFASLAGlrRLKKLSLDQNKIVRIPYL--QQIQLRDGSGDWVTEGPNPQKELQPQMWIFET-----P 311
Cdd:PRK15370  203 TLILDNNELK--SLPENLQG--NIKTLYANSNQLTSIPATlpDTIQEMELSINRITELPERLPSALQSLDLFHNkisclP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 312 DEQP-----------NYTVLPMKKDVDRTEVVFssypgFSTSETAKVCSLPPMFEILPV--KSLKARNQTLAPpfpELRY 378
Cdd:PRK15370  279 ENLPeelrylsvydnSIRTLPAHLPSGITHLNV-----QSNSLTALPETLPPGLKTLEAgeNALTSLPASLPP---ELQV 350

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1039779190 379 LSLAYNKIAkedaVLPAALFPSLCELVFHNNPLVAHTRGIPPLLK 423
Cdd:PRK15370  351 LDVSKNQIT----VLPETLPPTITTLDVSRNALTNLPENLPAALQ 391
LRR_8 pfam13855
Leucine rich repeat;
194-272 5.99e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 194 PHLRVLLLTGNGLTSLPPnmavkeqeasmtsltskKYILRFPALETLMLDDNKLS--NPSCFaslAGLRRLKKLSLDQNK 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-----------------GAFKGLSNLKVLDLSNNLLTtlSPGAF---SGLPSLRYLDLSGNR 60


                  .
gi 1039779190 272 I 272
Cdd:pfam13855  61 L 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 171-272 9.39e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 9.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 171 TLEFLDLSFNSLTEEAI---C-DLGILPHLRVLLLTGNGLTslppnmavkEQEASMTSLTskkyILRFPALETLMLDDNK 246
Cdd:cd00116   166 DLKELNLANNGIGDAGIralAeGLKANCNLEVLDLNNNGLT---------DEGASALAET----LASLKSLEVLNLGDNN 232

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039779190 247 LSNPS----CFASLAGLRRLKKLSLDQNKI 272
Cdd:cd00116   233 LTDAGaaalASALLSPNISLLTLSLSCNDI 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
120-280 2.29e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 120 KDFKHFTSVIYINASENL---LPLDVFHtFPVLKELELAFNGIKMVYVKYGDFKTLEFLDLSFNSLTE--EAICDLgilP 194
Cdd:COG4886   107 EELSNLTNLESLDLSGNQltdLPEELAN-LTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDlpEELGNL---T 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 195 HLRVLLLTGNGLTSLPPNMAvkeqeasmtsltskkyilRFPALETLMLDDNKLSNPScfASLAGLRRLKKLSLDQNKIVR 274
Cdd:COG4886   183 NLKELDLSNNQITDLPEPLG------------------NLTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTD 242


                  ....*.
gi 1039779190 275 IPYLQQ 280
Cdd:COG4886   243 LPELGN 248
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
102-327 6.82e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 6.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 102 SDLCTINVSGMKFSKAkEKDFKHFTSVIYINASENL---LPlDVFHTFPVLKELELAFNGIKMVYVKYGDFKTLEFLDLS 178
Cdd:COG4886   113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQltdLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 179 FNSLTEEAiCDLGILPHLRVLLLTGNGLTSLPPNMA----VKEQEASMTSLTSKKYILRFPALETLMLDDNKLSNpscFA 254
Cdd:COG4886   191 NNQITDLP-EPLGNLTNLEELDLSGNQLTDLPEPLAnltnLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTD---LP 266

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039779190 255 SLAGLRRLKKLSLDQNKIVRIpYLQQIQLRDGSGDWVTEGPNPQKELQPQMWIFETPDEQPNYTVLPMKKDVD 327
Cdd:COG4886   267 PLANLTNLKTLDLSNNQLTDL-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLT 338
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 102-277 4.67e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 4.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 102 SDLCTINVSGMKFSKAKEKDFKHFTSVIYINASENLL----PLDVFHTFPVLKELELAFNGIKMVyVKYGDFKTLEFLDL 177
Cdd:PLN00113   69 SRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLsgpiPDDIFTTSSSLRYLNLSNNNFTGS-IPRGSIPNLETLDL 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 178 SFNSLTEEAICDLGILPHLRVLLLTGNGLTSLPPNmavkeqeaSMTSLTSkkyilrfpaLETLMLDDNKLSNpSCFASLA 257
Cdd:PLN00113  148 SNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPN--------SLTNLTS---------LEFLTLASNQLVG-QIPRELG 209

                         170       180
                  ....*....|....*....|.
gi 1039779190 258 GLRRLKKLSLDQNKIV-RIPY 277
Cdd:PLN00113  210 QMKSLKWIYLGYNNLSgEIPY 230
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
239-423 5.51e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.08  E-value: 5.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 239 TLMLDDNKLSnpSCFASLAGlrRLKKLSLDQNKIVRIPYL--QQIQLRDGSGDWVTEGPNPQKELQPQMWIFET-----P 311
Cdd:PRK15370  203 TLILDNNELK--SLPENLQG--NIKTLYANSNQLTSIPATlpDTIQEMELSINRITELPERLPSALQSLDLFHNkisclP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 312 DEQP-----------NYTVLPMKKDVDRTEVVFssypgFSTSETAKVCSLPPMFEILPV--KSLKARNQTLAPpfpELRY 378
Cdd:PRK15370  279 ENLPeelrylsvydnSIRTLPAHLPSGITHLNV-----QSNSLTALPETLPPGLKTLEAgeNALTSLPASLPP---ELQV 350

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1039779190 379 LSLAYNKIAkedaVLPAALFPSLCELVFHNNPLVAHTRGIPPLLK 423
Cdd:PRK15370  351 LDVSKNQIT----VLPETLPPTITTLDVSRNALTNLPENLPAALQ 391
LRR_8 pfam13855
Leucine rich repeat;
194-272 5.99e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 5.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 194 PHLRVLLLTGNGLTSLPPnmavkeqeasmtsltskKYILRFPALETLMLDDNKLS--NPSCFaslAGLRRLKKLSLDQNK 271
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDD-----------------GAFKGLSNLKVLDLSNNLLTtlSPGAF---SGLPSLRYLDLSGNR 60


                  .
gi 1039779190 272 I 272
Cdd:pfam13855  61 L 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
130-423 3.14e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 130 YINASENLLPLDVFHTFPVLKELELAFNGIKMVYVKYGDFKTLEFLDLSFNSLTEEAICDLGILPHLRVLLLTGNGLTSL 209
Cdd:COG4886     3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 210 PPNMAVKEQEASMTSLTS-----KKYILRFPALETLMLDDNKLSN-PscfASLAGLRRLKKLSLDQNKIVRIPY------ 277
Cdd:COG4886    83 SLLLLGLTDLGDLTNLTEldlsgNEELSNLTNLESLDLSGNQLTDlP---EELANLTNLKELDLSNNQLTDLPEplgnlt 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 278 -LQQIQLrdgSGDWVTEGPNPQKELqpqmwifetpdeqPNYTVLpmkkDVDRTevvfssypgfstsetaKVCSLPPMFEI 356
Cdd:COG4886   160 nLKSLDL---SNNQLTDLPEELGNL-------------TNLKEL----DLSNN----------------QITDLPEPLGN 203

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039779190 357 LpvKSLK----ARNQ--TLAPPF---PELRYLSLAYNKIAKedavLPA-ALFPSLCELVFHNNPLvahtRGIPPLLK 423
Cdd:COG4886   204 L--TNLEeldlSGNQltDLPEPLanlTNLETLDLSNNQLTD----LPElGNLTNLEELDLSNNQL----TDLPPLAN 270
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 171-272 9.39e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 9.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 171 TLEFLDLSFNSLTEEAI---C-DLGILPHLRVLLLTGNGLTslppnmavkEQEASMTSLTskkyILRFPALETLMLDDNK 246
Cdd:cd00116   166 DLKELNLANNGIGDAGIralAeGLKANCNLEVLDLNNNGLT---------DEGASALAET----LASLKSLEVLNLGDNN 232

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039779190 247 LSNPS----CFASLAGLRRLKKLSLDQNKI 272
Cdd:cd00116   233 LTDAGaaalASALLSPNISLLTLSLSCNDI 262
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 177-275 6.42e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 6.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 177 LSFNSLTEEAICDLGILPHLRVLLLTGNGLTSLPpnmavkeqeasmtSLTSkkyilrFPALETLMLDDNKLSnpsCFASL 256
Cdd:cd21340     7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIE-------------NLEF------LTNLTHLYLQNNQIE---KIENL 64

                          90
                  ....*....|....*....
gi 1039779190 257 AGLRRLKKLSLDQNKIVRI 275
Cdd:cd21340    65 ENLVNLKKLYLGGNRISVV 83
LRR_8 pfam13855
Leucine rich repeat;
147-206 2.18e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039779190 147 PVLKELELAFNGIKMVYVKY-GDFKTLEFLDLSFNSLT---EEAICDLgilPHLRVLLLTGNGL 206
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTtlsPGAFSGL---PSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 181-276 2.52e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 181 SLTEEAICDLGILPHLRVLLLTGNGLTSLppnmavkeqeASMTSLTSkkyilrfpaLETLMLDDNKLSNPSCFA-SLAGL 259
Cdd:cd21340   107 KLTFDPRSLAALSNSLRVLNISGNNIDSL----------EPLAPLRN---------LEQLDASNNQISDLEELLdLLSSW 167

                          90
                  ....*....|....*..
gi 1039779190 260 RRLKKLSLDQNKIVRIP 276
Cdd:cd21340   168 PSLRELDLTGNPVCKKP 184
PLN03150 PLN03150
hypothetical protein; Provisional
 149-211 4.50e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 4.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039779190 149 LKELELAFNGIK-MVYVKYGDFKTLEFLDLSFNSLTEEAICDLGILPHLRVLLLTGNGLTSLPP 211
Cdd:PLN03150  444 LQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVP 507
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 172-280 5.51e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.00  E-value: 5.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039779190 172 LEFLDLSFNSLTEeaICDLGILPHLRVLLLTGN------GLTS-------------LPPNMAVKEQEASMTSLTskkyil 232
Cdd:cd21340    48 LTHLYLQNNQIEK--IENLENLVNLKKLYLGGNrisvveGLENltnleelhienqrLPPGEKLTFDPRSLAALS------ 119

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1039779190 233 rfPALETLMLDDNKLSNPSCfasLAGLRRLKKLSLDQNKIVRIPYLQQ 280
Cdd:cd21340   120 --NSLRVLNISGNNIDSLEP---LAPLRNLEQLDASNNQISDLEELLD 162
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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