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Conserved domains on  [gi|1034594131|ref|XP_016878584|]
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protein fantom isoform X5 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
C2-C2_1 pfam11618
First C2 domain of RPGR-interacting protein 1; This domain is the first, more N-terminal, C2 ...
601-742 1.32e-77

First C2 domain of RPGR-interacting protein 1; This domain is the first, more N-terminal, C2 domain on X-linked retinitis pigmentosa GTPase regulator-interacting proteins, or RPGR-interacting proteins.


:

Pssm-ID: 463310  Cd Length: 143  Bit Score: 251.78  E-value: 1.32e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  601 TIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKN 680
Cdd:pfam11618    1 TVELERGENLFELHIGGVTFSPEALRALGDKEPSTFCTYDFYDFETQTTPVVRGLNPFYDFTSQYKVTVDDLFLQYLQTN 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034594131  681 TITLEVHQAYSTEYETIAACQLKFHEILEK-SGRIFCTASLIGTKGDIPNFGTVEYWFRLRVP 742
Cdd:pfam11618   81 SLTLELHQALGVDFKTLAAAQLRLHGLLEDrGGRIHGTVTLTGVEGEIQIIGTLEYWIRLRVP 143
RPGR1_C pfam18111
Retinitis pigmentosa G-protein regulator interacting C-terminal; This is the C-terminal domain ...
1069-1232 3.52e-71

Retinitis pigmentosa G-protein regulator interacting C-terminal; This is the C-terminal domain of retinitis pigmentosa G-protein regulator (RPGR) interacting protein-1 present in Homo sapiens. A mutation in RPGR interacting protein-1 can be observed in the eye disease Leber congenital amaurosis. The domain is commonly known as the RPGR-interacting domain (RID) and is thought to have a C2-like fold.


:

Pssm-ID: 465655  Cd Length: 166  Bit Score: 234.62  E-value: 3.52e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131 1069 PSEKIRIEIIALSL-NDSQVTMDDTIQRLFVECRFYSLPAE--ETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDIL 1145
Cdd:pfam18111    1 DSDTIRIEIISLQLlNESEVMQDDNIQQLFVEYRFLGRPEEetETPVSLPKPKTGQELYYNFSKVIDVDKEKNSARREIL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131 1146 KAILQKQEMPNRSLRFTVVSDPPeDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHA 1225
Cdd:pfam18111   81 RSMLLPEDPNQGNLKFTVVSEPL-DTEDGECEEIGYAYVDLKQILQSGRDIIEQDLDVKDARDENEQIGKLKVSVEALAA 159

                   ....*..
gi 1034594131 1226 LQSVYKQ 1232
Cdd:pfam18111  160 LRAIYSE 166
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
201-449 9.33e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 9.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElsllQLREQQATDQRSNIRDNVEMIKLHKQLVEKSN 280
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE----QLEERIAQLSKELTELEAEIEELEERLEEAEE 775
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE-------QRLKCCSLEKQLHSmkfSERRIEELQDRINDLEK 353
Cdd:TIGR02168  776 ELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLlneeaanLRERLESLERRIAA---TERRLEDLEEQIEELSE 852
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  354 ERELLKENYDKLydSAFSAAHEEQWKLKEQQLKVQIAQLEtALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQL 433
Cdd:TIGR02168  853 DIESLAAEIEEL--EELIEELESELEALLNERASLEEALA-LLRSELEELSEELRELESKRSELRRELEELREKLAQLEL 929
                          250
                   ....*....|....*.
gi 1034594131  434 QYLEQKQQLDELKKRI 449
Cdd:TIGR02168  930 RLEGLEVRIDNLQERL 945
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
796-895 4.29e-13

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


:

Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 66.32  E-value: 4.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  796 LHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMdldrylkSESLSFYVFDDSDT 875
Cdd:cd00030      1 LRVTVIEARNLPAKDLNGKSDPYVKVSLGGKQKFKTKVVKNTLNPVWNETFEFPVLDPE-------SDTLTVEVWDKDRF 73
                           90       100
                   ....*....|....*....|
gi 1034594131  876 QENIYIGKVNVPLISLAHDR 895
Cdd:cd00030     74 SKDDFLGEVEIPLSELLDSG 93
CCDC158 super family cl37899
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
39-576 5.68e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


The actual alignment was detected with superfamily member pfam15921:

Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.45  E-value: 5.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   39 RQAVSRVSRE---ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLvndkkRYERVGGGPKRLGRDVEMEEMIEQL 115
Cdd:pfam15921   73 KEHIERVLEEyshQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEM-----QMERDAMADIRRRESQSQEDLRNQL 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  116 QEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGlqecprKGIKFQDAdvaetphpMFTK 195
Cdd:pfam15921  148 QNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASG------KKIYEHDS--------MSTM 213
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  196 YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK-----------------ENEIELSLLQLREQQATDQ 258
Cdd:pfam15921  214 HFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKielllqqhqdrieqlisEHEVEITGLTEKASSARSQ 293
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  259 RSNIRDNVEMIKlhkQLVEKSNA-----LSAMEGKFIQLQEKQRTL-RISHDALmangDELNMQL--KEQRLKCCSLEKQ 330
Cdd:pfam15921  294 ANSIQSQLEIIQ---EQARNQNSmymrqLSDLESTVSQLRSELREAkRMYEDKI----EELEKQLvlANSELTEARTERD 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  331 LHSMKfSERRIEELQDRINDL---EKERELLKENYDKLYD----SAFSAAHEEQwKLKEQQLKVQiaQLETALKsdlTDK 403
Cdd:pfam15921  367 QFSQE-SGNLDDQLQKLLADLhkrEKELSLEKEQNKRLWDrdtgNSITIDHLRR-ELDDRNMEVQ--RLEALLK---AMK 439
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  404 TEILDRLKTERGALINQNEKLvQENRELQLQYLEQKQQL----DELK-KRIKLYNQENDINadELSEALLLIKAQKEQKN 478
Cdd:pfam15921  440 SECQGQMERQMAAIQGKNESL-EKVSSLTAQLESTKEMLrkvvEELTaKKMTLESSERTVS--DLTASLQEKERAIEATN 516
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  479 GDLSFL-VKVDSEIN-----KDLERSMRELQAT-HAETVQELEKTRNMLIMQHKINKDYQ-----------MEVEAVtrK 540
Cdd:pfam15921  517 AEITKLrSRVDLKLQelqhlKNEGDHLRNVQTEcEALKLQMAEKDKVIEILRQQIENMTQlvgqhgrtagaMQVEKA--Q 594
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1034594131  541 MENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDI 576
Cdd:pfam15921  595 LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDL 630
 
Name Accession Description Interval E-value
C2-C2_1 pfam11618
First C2 domain of RPGR-interacting protein 1; This domain is the first, more N-terminal, C2 ...
601-742 1.32e-77

First C2 domain of RPGR-interacting protein 1; This domain is the first, more N-terminal, C2 domain on X-linked retinitis pigmentosa GTPase regulator-interacting proteins, or RPGR-interacting proteins.


Pssm-ID: 463310  Cd Length: 143  Bit Score: 251.78  E-value: 1.32e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  601 TIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKN 680
Cdd:pfam11618    1 TVELERGENLFELHIGGVTFSPEALRALGDKEPSTFCTYDFYDFETQTTPVVRGLNPFYDFTSQYKVTVDDLFLQYLQTN 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034594131  681 TITLEVHQAYSTEYETIAACQLKFHEILEK-SGRIFCTASLIGTKGDIPNFGTVEYWFRLRVP 742
Cdd:pfam11618   81 SLTLELHQALGVDFKTLAAAQLRLHGLLEDrGGRIHGTVTLTGVEGEIQIIGTLEYWIRLRVP 143
RPGR1_C pfam18111
Retinitis pigmentosa G-protein regulator interacting C-terminal; This is the C-terminal domain ...
1069-1232 3.52e-71

Retinitis pigmentosa G-protein regulator interacting C-terminal; This is the C-terminal domain of retinitis pigmentosa G-protein regulator (RPGR) interacting protein-1 present in Homo sapiens. A mutation in RPGR interacting protein-1 can be observed in the eye disease Leber congenital amaurosis. The domain is commonly known as the RPGR-interacting domain (RID) and is thought to have a C2-like fold.


Pssm-ID: 465655  Cd Length: 166  Bit Score: 234.62  E-value: 3.52e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131 1069 PSEKIRIEIIALSL-NDSQVTMDDTIQRLFVECRFYSLPAE--ETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDIL 1145
Cdd:pfam18111    1 DSDTIRIEIISLQLlNESEVMQDDNIQQLFVEYRFLGRPEEetETPVSLPKPKTGQELYYNFSKVIDVDKEKNSARREIL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131 1146 KAILQKQEMPNRSLRFTVVSDPPeDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHA 1225
Cdd:pfam18111   81 RSMLLPEDPNQGNLKFTVVSEPL-DTEDGECEEIGYAYVDLKQILQSGRDIIEQDLDVKDARDENEQIGKLKVSVEALAA 159

                   ....*..
gi 1034594131 1226 LQSVYKQ 1232
Cdd:pfam18111  160 LRAIYSE 166
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
201-449 9.33e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 9.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElsllQLREQQATDQRSNIRDNVEMIKLHKQLVEKSN 280
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE----QLEERIAQLSKELTELEAEIEELEERLEEAEE 775
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE-------QRLKCCSLEKQLHSmkfSERRIEELQDRINDLEK 353
Cdd:TIGR02168  776 ELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLlneeaanLRERLESLERRIAA---TERRLEDLEEQIEELSE 852
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  354 ERELLKENYDKLydSAFSAAHEEQWKLKEQQLKVQIAQLEtALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQL 433
Cdd:TIGR02168  853 DIESLAAEIEEL--EELIEELESELEALLNERASLEEALA-LLRSELEELSEELRELESKRSELRRELEELREKLAQLEL 929
                          250
                   ....*....|....*.
gi 1034594131  434 QYLEQKQQLDELKKRI 449
Cdd:TIGR02168  930 RLEGLEVRIDNLQERL 945
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
201-484 6.53e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.90  E-value: 6.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQAtdqrsnirdnvEMIKLHKQLVEKSN 280
Cdd:COG1196    241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA-----------ELARLEQDIARLEE 309
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHsmKFSERRIEELQDRINDLEKERELLKE 360
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA--EAEEALLEAEAELAEAEEELEELAEE 387
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQlqylEQKQ 440
Cdd:COG1196    388 LLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE----ALLE 463
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1034594131  441 QLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 484
Cdd:COG1196    464 LLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFL 507
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
796-895 4.29e-13

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 66.32  E-value: 4.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  796 LHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMdldrylkSESLSFYVFDDSDT 875
Cdd:cd00030      1 LRVTVIEARNLPAKDLNGKSDPYVKVSLGGKQKFKTKVVKNTLNPVWNETFEFPVLDPE-------SDTLTVEVWDKDRF 73
                           90       100
                   ....*....|....*....|
gi 1034594131  876 QENIYIGKVNVPLISLAHDR 895
Cdd:cd00030     74 SKDDFLGEVEIPLSELLDSG 93
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
39-576 5.68e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.45  E-value: 5.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   39 RQAVSRVSRE---ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLvndkkRYERVGGGPKRLGRDVEMEEMIEQL 115
Cdd:pfam15921   73 KEHIERVLEEyshQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEM-----QMERDAMADIRRRESQSQEDLRNQL 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  116 QEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGlqecprKGIKFQDAdvaetphpMFTK 195
Cdd:pfam15921  148 QNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASG------KKIYEHDS--------MSTM 213
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  196 YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK-----------------ENEIELSLLQLREQQATDQ 258
Cdd:pfam15921  214 HFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKielllqqhqdrieqlisEHEVEITGLTEKASSARSQ 293
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  259 RSNIRDNVEMIKlhkQLVEKSNA-----LSAMEGKFIQLQEKQRTL-RISHDALmangDELNMQL--KEQRLKCCSLEKQ 330
Cdd:pfam15921  294 ANSIQSQLEIIQ---EQARNQNSmymrqLSDLESTVSQLRSELREAkRMYEDKI----EELEKQLvlANSELTEARTERD 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  331 LHSMKfSERRIEELQDRINDL---EKERELLKENYDKLYD----SAFSAAHEEQwKLKEQQLKVQiaQLETALKsdlTDK 403
Cdd:pfam15921  367 QFSQE-SGNLDDQLQKLLADLhkrEKELSLEKEQNKRLWDrdtgNSITIDHLRR-ELDDRNMEVQ--RLEALLK---AMK 439
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  404 TEILDRLKTERGALINQNEKLvQENRELQLQYLEQKQQL----DELK-KRIKLYNQENDINadELSEALLLIKAQKEQKN 478
Cdd:pfam15921  440 SECQGQMERQMAAIQGKNESL-EKVSSLTAQLESTKEMLrkvvEELTaKKMTLESSERTVS--DLTASLQEKERAIEATN 516
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  479 GDLSFL-VKVDSEIN-----KDLERSMRELQAT-HAETVQELEKTRNMLIMQHKINKDYQ-----------MEVEAVtrK 540
Cdd:pfam15921  517 AEITKLrSRVDLKLQelqhlKNEGDHLRNVQTEcEALKLQMAEKDKVIEILRQQIENMTQlvgqhgrtagaMQVEKA--Q 594
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1034594131  541 MENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDI 576
Cdd:pfam15921  595 LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDL 630
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
368-576 1.37e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  368 SAFSAAHEEQWKLKEQ--QLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLvqenRELQLQYLEQKQQLDEL 445
Cdd:COG4942     13 LAAAAQADAAAEAEAEleQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI----RALEQELAALEAELAEL 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  446 KKRIKLYNQENDINADELSEalLLIKAQKEQKNGDLSFLVKVDS--------EINKDLERSMRELQATHAETVQELEKTR 517
Cdd:COG4942     89 EKEIAELRAELEAQKEELAE--LLRALYRLGRQPPLALLLSPEDfldavrrlQYLKYLAPARREQAEELRADLAELAALR 166
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034594131  518 NMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDI 576
Cdd:COG4942    167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
C2 smart00239
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ...
796-891 1.79e-09

Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.


Pssm-ID: 214577 [Multi-domain]  Cd Length: 101  Bit Score: 55.96  E-value: 1.79e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   796 LHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHD--TAIIPSSNDPQFDDHMYFPVPmnmdldrYLKSESLSFYVFDDS 873
Cdd:smart00239    2 LTVKIISARNLPPKDKGGKSDPYVKVSLDGDPKEKkkTKVVKNTLNPVWNETFEFEVP-------PPELAELEIEVYDKD 74
                            90
                    ....*....|....*...
gi 1034594131   874 DTQENIYIGKVNVPLISL 891
Cdd:smart00239   75 RFGRDDFIGQVTIPLSDL 92
C2 pfam00168
C2 domain;
796-903 7.43e-09

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 54.63  E-value: 7.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  796 LHITIRCCNHLQSRASHLQPHPYV-VYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDldrylksESLSFYVFDDSD 874
Cdd:pfam00168    3 LTVTVIEAKNLPPKDGNGTSDPYVkVYLLDGKQKKKTKVVKNTLNPVWNETFTFSVPDPEN-------AVLEIEVYDYDR 75
                           90       100
                   ....*....|....*....|....*....
gi 1034594131  875 TQENIYIGKVNVPLISLAHDRCISGIFEL 903
Cdd:pfam00168   76 FGRDDFIGEVRIPLSELDSGEGLDGWYPL 104
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
211-573 5.07e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 57.49  E-value: 5.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  211 LENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQrsnirdnvemiKLHKQLVEKSNALSAMEGKFI 290
Cdd:pfam01576   73 LEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQ-----------KLQLEKVTTEAKIKKLEEDIL 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  291 QLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSmkfSERRIEELQDRINDLEKERELLKENYDKLyDSAF 370
Cdd:pfam01576  142 LLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNK---HEAMISDLEERLKKEEKGRQELEKAKRKL-EGES 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  371 SAAHEEQWKLKEQ--QLKVQIAQLETALKSdltdkteILDRLKTERGalinQNEKLVQENRELQLQYLEQKQQLD-ELKK 447
Cdd:pfam01576  218 TDLQEQIAELQAQiaELRAQLAKKEEELQA-------ALARLEEETA----QKNNALKKIRELEAQISELQEDLEsERAA 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  448 RIKLYNQENDINAD------ELSEALLLIKAQKE---QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE------ 512
Cdd:pfam01576  287 RNKAEKQRRDLGEElealktELEDTLDTTAAQQElrsKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEElteqle 366
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034594131  513 ---------------LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL 573
Cdd:pfam01576  367 qakrnkanlekakqaLESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSEL 442
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
201-576 7.14e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 7.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEhlAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSN 280
Cdd:PRK03918   233 LEELKEEIEELEKELESLEGSKRKLE--EKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELR 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKfiqLQEKQRTLRishdALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER---RIEELQDRINDLEKEREL 357
Cdd:PRK03918   311 EIEKRLSR---LEEEINGIE----ERIKELEEKEERLEELKKKLKELEKRLEELEERHElyeEAKAKKEELERLKKRLTG 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  358 L-KENYDKLYDSAFSAAHEEQWKLKE-----QQLKVQIAQLETAL-------------KSDLTDK---------TEILDR 409
Cdd:PRK03918   384 LtPEKLEKELEELEKAKEEIEEEISKitariGELKKEIKELKKAIeelkkakgkcpvcGRELTEEhrkelleeyTAELKR 463
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  410 LKTERGALINQNEKLVQENRELQ---------LQYLEQKQQLDELKKRIKLYNQENDINADELSEAL--LLIKAQKEQKN 478
Cdd:PRK03918   464 IEKELKEIEEKERKLRKELRELEkvlkkeselIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLkeKLIKLKGEIKS 543
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  479 gdlsflVKVDSEINKDLERSMRELQathaETVQELEKTRNMLImqHKINKDYQMEVEAVTRKMENLQQDYE--LKVEQYV 556
Cdd:PRK03918   544 ------LKKELEKLEELKKKLAELE----KKLDELEEELAELL--KELEELGFESVEELEERLKELEPFYNeyLELKDAE 611
                          410       420
                   ....*....|....*....|
gi 1034594131  557 HLLDIRAARIHKLEAQLKDI 576
Cdd:PRK03918   612 KELEREEKELKKLEEELDKA 631
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
48-573 7.27e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 7.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   48 EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL-GRDVEMEEMIEQLQEKVHELEKQN 126
Cdd:PRK03918   203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLeEKIRELEERIEELKKEIEELEEKV 282
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  127 ETLKN---------RLISAKQQLQTQGYR--------QTPYNNVQSRINTGRRKANENAGLQEcPRKGIKfQDADVAETP 189
Cdd:PRK03918   283 KELKElkekaeeyiKLSEFYEEYLDELREiekrlsrlEEEINGIEERIKELEEKEERLEELKK-KLKELE-KRLEELEER 360
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  190 HpmftkygnSLLEEARGEIRNLENViqSQRGQIEELEHLAEILKTQLRRKEnEIELSLLQLREQQAT--DQRSNIRDNVE 267
Cdd:PRK03918   361 H--------ELYEEAKAKKEELERL--KKRLTGLTPEKLEKELEELEKAKE-EIEEEISKITARIGElkKEIKELKKAIE 429
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  268 MIKLHK----------------QLVEKSNA-LSAMEGKFIQLQEKQRTLRishdalmANGDELNMQLKEQR--LKCCSLE 328
Cdd:PRK03918   430 ELKKAKgkcpvcgrelteehrkELLEEYTAeLKRIEKELKEIEEKERKLR-------KELRELEKVLKKESelIKLKELA 502
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  329 KQLHSM--KFSERRIEELQDRindlEKERELLKENYDKLyDSAFSAAHEEQWKLKEqqLKVQIAQLETALKSDLTDKTEI 406
Cdd:PRK03918   503 EQLKELeeKLKKYNLEELEKK----AEEYEKLKEKLIKL-KGEIKSLKKELEKLEE--LKKKLAELEKKLDELEEELAEL 575
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  407 LDRLKTERGALINQNEKLVQENRELQLQYLEQK---QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNgdlSF 483
Cdd:PRK03918   576 LKELEELGFESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE---EL 652
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  484 LVKVDSEINKDLERSMRELQATHA----------ETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYElKVE 553
Cdd:PRK03918   653 EKKYSEEEYEELREEYLELSRELAglraeleeleKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELRE-KVK 731
                          570       580
                   ....*....|....*....|.
gi 1034594131  554 QYVHLLDIRA-ARIHKLEAQL 573
Cdd:PRK03918   732 KYKALLKERAlSKVGEIASEI 752
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
341-582 1.51e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 49.68  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  341 IEELQDRINDLEKERElLKENYDKLydsafsaaheeQWKLKEQQLKVQIAQLETALKS------DLTDKTEILDRLKTER 414
Cdd:TIGR02169  193 IDEKRQQLERLRRERE-KAERYQAL-----------LKEKREYEGYELLKEKEALERQkeaierQLASLEEELEKLTEEI 260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  415 GALINQNEKLVQENRELQLQ--------YLEQKQQLDELKKRIKLYNQENDINADELSEalllikAQKEQKNGDlSFLVK 486
Cdd:TIGR02169  261 SELEKRLEEIEQLLEELNKKikdlgeeeQLRVKEKIGELEAEIASLERSIAEKERELED------AEERLAKLE-AEIDK 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  487 VDSEInKDLERSMRELQATHA---ETVQELEKTRNMLIMQ-------HKI----NKDYQMEVEAVTRKMENLQQDY---- 548
Cdd:TIGR02169  334 LLAEI-EELEREIEEERKRRDkltEEYAELKEELEDLRAEleevdkeFAEtrdeLKDYREKLEKLKREINELKRELdrlq 412
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1034594131  549 ELKVEQYVHLLDIRA------ARIHKLEAQLKDIAYGTKQ 582
Cdd:TIGR02169  413 EELQRLSEELADLNAaiagieAKINELEEEKEDKALEIKK 452
 
Name Accession Description Interval E-value
C2-C2_1 pfam11618
First C2 domain of RPGR-interacting protein 1; This domain is the first, more N-terminal, C2 ...
601-742 1.32e-77

First C2 domain of RPGR-interacting protein 1; This domain is the first, more N-terminal, C2 domain on X-linked retinitis pigmentosa GTPase regulator-interacting proteins, or RPGR-interacting proteins.


Pssm-ID: 463310  Cd Length: 143  Bit Score: 251.78  E-value: 1.32e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  601 TIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKN 680
Cdd:pfam11618    1 TVELERGENLFELHIGGVTFSPEALRALGDKEPSTFCTYDFYDFETQTTPVVRGLNPFYDFTSQYKVTVDDLFLQYLQTN 80
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034594131  681 TITLEVHQAYSTEYETIAACQLKFHEILEK-SGRIFCTASLIGTKGDIPNFGTVEYWFRLRVP 742
Cdd:pfam11618   81 SLTLELHQALGVDFKTLAAAQLRLHGLLEDrGGRIHGTVTLTGVEGEIQIIGTLEYWIRLRVP 143
RPGR1_C pfam18111
Retinitis pigmentosa G-protein regulator interacting C-terminal; This is the C-terminal domain ...
1069-1232 3.52e-71

Retinitis pigmentosa G-protein regulator interacting C-terminal; This is the C-terminal domain of retinitis pigmentosa G-protein regulator (RPGR) interacting protein-1 present in Homo sapiens. A mutation in RPGR interacting protein-1 can be observed in the eye disease Leber congenital amaurosis. The domain is commonly known as the RPGR-interacting domain (RID) and is thought to have a C2-like fold.


Pssm-ID: 465655  Cd Length: 166  Bit Score: 234.62  E-value: 3.52e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131 1069 PSEKIRIEIIALSL-NDSQVTMDDTIQRLFVECRFYSLPAE--ETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDIL 1145
Cdd:pfam18111    1 DSDTIRIEIISLQLlNESEVMQDDNIQQLFVEYRFLGRPEEetETPVSLPKPKTGQELYYNFSKVIDVDKEKNSARREIL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131 1146 KAILQKQEMPNRSLRFTVVSDPPeDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHA 1225
Cdd:pfam18111   81 RSMLLPEDPNQGNLKFTVVSEPL-DTEDGECEEIGYAYVDLKQILQSGRDIIEQDLDVKDARDENEQIGKLKVSVEALAA 159

                   ....*..
gi 1034594131 1226 LQSVYKQ 1232
Cdd:pfam18111  160 LRAIYSE 166
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
201-449 9.33e-17

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 86.26  E-value: 9.33e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElsllQLREQQATDQRSNIRDNVEMIKLHKQLVEKSN 280
Cdd:TIGR02168  700 LAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE----QLEERIAQLSKELTELEAEIEELEERLEEAEE 775
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE-------QRLKCCSLEKQLHSmkfSERRIEELQDRINDLEK 353
Cdd:TIGR02168  776 ELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLlneeaanLRERLESLERRIAA---TERRLEDLEEQIEELSE 852
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  354 ERELLKENYDKLydSAFSAAHEEQWKLKEQQLKVQIAQLEtALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQL 433
Cdd:TIGR02168  853 DIESLAAEIEEL--EELIEELESELEALLNERASLEEALA-LLRSELEELSEELRELESKRSELRRELEELREKLAQLEL 929
                          250
                   ....*....|....*.
gi 1034594131  434 QYLEQKQQLDELKKRI 449
Cdd:TIGR02168  930 RLEGLEVRIDNLQERL 945
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
201-484 6.53e-14

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 76.90  E-value: 6.53e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQAtdqrsnirdnvEMIKLHKQLVEKSN 280
Cdd:COG1196    241 LEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLA-----------ELARLEQDIARLEE 309
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHsmKFSERRIEELQDRINDLEKERELLKE 360
Cdd:COG1196    310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELA--EAEEALLEAEAELAEAEEELEELAEE 387
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQlqylEQKQ 440
Cdd:COG1196    388 LLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE----ALLE 463
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1034594131  441 QLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 484
Cdd:COG1196    464 LLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFL 507
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
198-576 2.13e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 2.13e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  198 NSLLEEARgEIRNLENviqsqrgQIEELEHLAEILKTQLrrkeneielsllqlreQQATDQRSNIRDNVEmiKLHKQLVE 277
Cdd:TIGR02168  670 SSILERRR-EIEELEE-------KIEELEEKIAELEKAL----------------AELRKELEELEEELE--QLRKELEE 723
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  278 KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSmkfSERRIEELQDRINDLEKEREL 357
Cdd:TIGR02168  724 LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE---AEAEIEELEAQIEQLKEELKA 800
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  358 LKENYDKLydsafSAAHEEQwKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALinqnEKLVQENRELQLQYLE 437
Cdd:TIGR02168  801 LREALDEL-----RAELTLL-NEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDI----ESLAAEIEELEELIEE 870
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  438 QKQQLDELKKRIklynqendinaDELSEALLLIKAQKEQKNGDLsflvKVDSEINKDLERSMRELQATHAETVQELEKTR 517
Cdd:TIGR02168  871 LESELEALLNER-----------ASLEEALALLRSELEELSEEL----RELESKRSELRRELEELREKLAQLELRLEGLE 935
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  518 NMLI-MQHKINKDYQMEVEAVTRKMENLqQDYELKVEQyvhlldiraaRIHKLEAQLKDI 576
Cdd:TIGR02168  936 VRIDnLQERLSEEYSLTLEEAEALENKI-EDDEEEARR----------RLKRLENKIKEL 984
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
106-496 2.44e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 75.09  E-value: 2.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  106 VEMEEMIEQLQEKVHELEKQNETLKnrlisaKQQLQTQGYR--QTPYNNVQSRINTGRRKANenaglqecpRKGIKFQDA 183
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSLE------RQAEKAERYKelKAELRELELALLVLRLEEL---------REELEELQE 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  184 DVAETphpmftkygNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKT---QLRRKENEIELSLLQLREQQATDQRS 260
Cdd:TIGR02168  247 ELKEA---------EEELEELTAELQELEEKLEELRLEVSELEEEIEELQKelyALANEISRLEQQKQILRERLANLERQ 317
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  261 NIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER- 339
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIAs 397
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  340 ---RIEELQDRINDLEKERELLKENydklydsafsaAHEEQWKLKEQQLKVQIAQLETalksdltdKTEILDRLKTERGA 416
Cdd:TIGR02168  398 lnnEIERLEARLERLEDRRERLQQE-----------IEELLKKLEEAELKELQAELEE--------LEEELEELQEELER 458
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  417 LINQNEKLVQENRELQLQYLEQKQQLDELKKRIK-LYNQENdiNADELSEALLLIKAQKEQKNGD---LSFLVKVDSEIN 492
Cdd:TIGR02168  459 LEEALEELREELEEAEQALDAAERELAQLQARLDsLERLQE--NLEGFSEGVKALLKNQSGLSGIlgvLSELISVDEGYE 536

                   ....
gi 1034594131  493 KDLE 496
Cdd:TIGR02168  537 AAIE 540
C2 cd00030
C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed ...
796-895 4.29e-13

C2 domain; The C2 domain was first identified in PKC. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.


Pssm-ID: 175973 [Multi-domain]  Cd Length: 102  Bit Score: 66.32  E-value: 4.29e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  796 LHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMdldrylkSESLSFYVFDDSDT 875
Cdd:cd00030      1 LRVTVIEARNLPAKDLNGKSDPYVKVSLGGKQKFKTKVVKNTLNPVWNETFEFPVLDPE-------SDTLTVEVWDKDRF 73
                           90       100
                   ....*....|....*....|
gi 1034594131  876 QENIYIGKVNVPLISLAHDR 895
Cdd:cd00030     74 SKDDFLGEVEIPLSELLDSG 93
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
39-576 5.68e-11

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 67.45  E-value: 5.68e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   39 RQAVSRVSRE---ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLvndkkRYERVGGGPKRLGRDVEMEEMIEQL 115
Cdd:pfam15921   73 KEHIERVLEEyshQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEM-----QMERDAMADIRRRESQSQEDLRNQL 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  116 QEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGlqecprKGIKFQDAdvaetphpMFTK 195
Cdd:pfam15921  148 QNTVHELEAAKCLKEDMLEDSNTQIEQLRKMMLSHEGVLQEIRSILVDFEEASG------KKIYEHDS--------MSTM 213
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  196 YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK-----------------ENEIELSLLQLREQQATDQ 258
Cdd:pfam15921  214 HFRSLGSAISKILRELDTEISYLKGRIFPVEDQLEALKSESQNKielllqqhqdrieqlisEHEVEITGLTEKASSARSQ 293
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  259 RSNIRDNVEMIKlhkQLVEKSNA-----LSAMEGKFIQLQEKQRTL-RISHDALmangDELNMQL--KEQRLKCCSLEKQ 330
Cdd:pfam15921  294 ANSIQSQLEIIQ---EQARNQNSmymrqLSDLESTVSQLRSELREAkRMYEDKI----EELEKQLvlANSELTEARTERD 366
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  331 LHSMKfSERRIEELQDRINDL---EKERELLKENYDKLYD----SAFSAAHEEQwKLKEQQLKVQiaQLETALKsdlTDK 403
Cdd:pfam15921  367 QFSQE-SGNLDDQLQKLLADLhkrEKELSLEKEQNKRLWDrdtgNSITIDHLRR-ELDDRNMEVQ--RLEALLK---AMK 439
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  404 TEILDRLKTERGALINQNEKLvQENRELQLQYLEQKQQL----DELK-KRIKLYNQENDINadELSEALLLIKAQKEQKN 478
Cdd:pfam15921  440 SECQGQMERQMAAIQGKNESL-EKVSSLTAQLESTKEMLrkvvEELTaKKMTLESSERTVS--DLTASLQEKERAIEATN 516
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  479 GDLSFL-VKVDSEIN-----KDLERSMRELQAT-HAETVQELEKTRNMLIMQHKINKDYQ-----------MEVEAVtrK 540
Cdd:pfam15921  517 AEITKLrSRVDLKLQelqhlKNEGDHLRNVQTEcEALKLQMAEKDKVIEILRQQIENMTQlvgqhgrtagaMQVEKA--Q 594
                          570       580       590
                   ....*....|....*....|....*....|....*.
gi 1034594131  541 MENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDI 576
Cdd:pfam15921  595 LEKEINDRRLELQEFKILKDKKDAKIRELEARVSDL 630
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
219-574 6.88e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 63.80  E-value: 6.88e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  219 RGQIEELehlAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEmiKLHKQlveKSNALsamegKFIQLQEKQRT 298
Cdd:COG1196    158 RAIIEEA---AGISKYKERKEEAERKLEATEENLERLEDILGELERQLE--PLERQ---AEKAE-----RYRELKEELKE 224
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  299 LRISH-----DALMANGDELNMQLKEQRLKCCSLEKQLHSMkfsERRIEELQDRINDLEKERELLKEnydKLYDSAFSAA 373
Cdd:COG1196    225 LEAELlllklRELEAELEELEAELEELEAELEELEAELAEL---EAELEELRLELEELELELEEAQA---EEYELLAELA 298
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  374 HEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIklyn 453
Cdd:COG1196    299 RLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL---- 374
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  454 QENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERsMRELQATHAETVQELEKTRNMLIMQHKINKDYQME 533
Cdd:COG1196    375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLER-LEEELEELEEALAELEEEEEEEEEALEEAAEEEAE 453
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|.
gi 1034594131  534 VEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 574
Cdd:COG1196    454 LEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLL 494
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
64-546 1.14e-09

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 62.73  E-value: 1.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   64 LKQHARKQEDKIKRMATKLIRLVND-KKRYERVGGGPKRLGRDvemEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQT 142
Cdd:TIGR04523   24 YKNIANKQDTEEKQLEKKLKTIKNElKNKEKELKNLDKNLNKD---EEKINNSNNKIKILEQQIKDLNDKLKKNKDKINK 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  143 QGYRQTPYNN-VQSRINTGRRKANENAGLQECPRKGIKFQDADVAE-TPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220
Cdd:TIGR04523  101 LNSDLSKINSeIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEiKKKEKELEKLNNKYNDLKKQKEELENELNLLEK 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  221 QIEELEHLAEILKTQLRRKEneIELSLLQLREQQAT----------DQRSNIRDNVEmiKLHKQLVEKSNALSAMEGKFI 290
Cdd:TIGR04523  181 EKLNIQKNIDKIKNKLLKLE--LLLSNLKKKIQKNKslesqiselkKQNNQLKDNIE--KKQQEINEKTTEISNTQTQLN 256
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  291 QLQEKQrtlrishdalmangDELNMQLKEQRLKccsLEKQLHSMKFSERRIEELQDRINDLEKEREllkENYDKLYDSAF 370
Cdd:TIGR04523  257 QLKDEQ--------------NKIKKQLSEKQKE---LEQNNKKIKELEKQLNQLKSEISDLNNQKE---QDWNKELKSEL 316
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  371 SAAHEEQWKLKEQ---------QLKVQIAQLET----------ALKSDLTDKTEILDRLKTERGALINQNEKLVQENREL 431
Cdd:TIGR04523  317 KNQEKKLEEIQNQisqnnkiisQLNEQISQLKKeltnsesensEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDL 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  432 QLQYLEQKQQLDELKKRIKLYNQENdinaDELSEALLLIKAQKEQKNGDLSFLVKVDSEIN-----------------KD 494
Cdd:TIGR04523  397 ESKIQNQEKLNQQKDEQIKKLQQEK----ELLEKEIERLKETIIKNNSEIKDLTNQDSVKEliiknldntresletqlKV 472
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034594131  495 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 546
Cdd:TIGR04523  473 LSRSINKIKQNLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKE 524
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
216-516 1.32e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.78  E-value: 1.32e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  216 QSQRGQIEELEHLAEILKTQLRRKENEIElsllqlreqQATDQRSNirdnvemikLHKQLVEKSNALSAMEGKFIQLQEK 295
Cdd:TIGR02169  677 QRLRERLEGLKRELSSLQSELRRIENRLD---------ELSQELSD---------ASRKIGEIEKEIEQLEQEEEKLKER 738
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  296 ----QRTLRISHDALMANGDE---LNMQLKEQRLKCCSLEKQLHSMK--FSERRIEELQDRINDLEKER----------- 355
Cdd:TIGR02169  739 leelEEDLSSLEQEIENVKSElkeLEARIEELEEDLHKLEEALNDLEarLSHSRIPEIQAELSKLEEEVsriearlreie 818
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  356 -ELLKENYDKLYDSAFSAAHEEQ---WKLKEQQLKVQIAQLET---ALKSDLTDKTEILDRLKTERGALINQNEKLVQEN 428
Cdd:TIGR02169  819 qKLNRLTLEKEYLEKEIQELQEQridLKEQIKSIEKEIENLNGkkeELEEELEELEAALRDLESRLGDLKKERDELEAQL 898
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  429 RELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSfLVKVDSEINKdLERSMRELQATHAE 508
Cdd:TIGR02169  899 RELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELS-LEDVQAELQR-VEEEIRALEPVNML 976

                   ....*...
gi 1034594131  509 TVQELEKT 516
Cdd:TIGR02169  977 AIQEYEEV 984
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
368-576 1.37e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.70  E-value: 1.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  368 SAFSAAHEEQWKLKEQ--QLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLvqenRELQLQYLEQKQQLDEL 445
Cdd:COG4942     13 LAAAAQADAAAEAEAEleQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI----RALEQELAALEAELAEL 88
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  446 KKRIKLYNQENDINADELSEalLLIKAQKEQKNGDLSFLVKVDS--------EINKDLERSMRELQATHAETVQELEKTR 517
Cdd:COG4942     89 EKEIAELRAELEAQKEELAE--LLRALYRLGRQPPLALLLSPEDfldavrrlQYLKYLAPARREQAEELRADLAELAALR 166
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034594131  518 NMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDI 576
Cdd:COG4942    167 AELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEEL 225
C2 smart00239
Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, ...
796-891 1.79e-09

Protein kinase C conserved region 2 (CalB); Ca2+-binding motif present in phospholipases, protein kinases C, and synaptotagmins (among others). Some do not appear to contain Ca2+-binding sites. Particular C2s appear to bind phospholipids, inositol polyphosphates, and intracellular proteins. Unusual occurrence in perforin. Synaptotagmin and PLC C2s are permuted in sequence with respect to N- and C-terminal beta strands. SMART detects C2 domains using one or both of two profiles.


Pssm-ID: 214577 [Multi-domain]  Cd Length: 101  Bit Score: 55.96  E-value: 1.79e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   796 LHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHD--TAIIPSSNDPQFDDHMYFPVPmnmdldrYLKSESLSFYVFDDS 873
Cdd:smart00239    2 LTVKIISARNLPPKDKGGKSDPYVKVSLDGDPKEKkkTKVVKNTLNPVWNETFEFEVP-------PPELAELEIEVYDKD 74
                            90
                    ....*....|....*...
gi 1034594131   874 DTQENIYIGKVNVPLISL 891
Cdd:smart00239   75 RFGRDDFIGQVTIPLSDL 92
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
201-448 1.88e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 61.32  E-value: 1.88e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIelsllQLREQQATDQRSNIRDN-VEMIKLHKQLVEKS 279
Cdd:COG4942     29 LEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRI-----RALEQELAALEAELAELeKEIAELRAELEAQK 103
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  280 NALSAMegkfiqLQEKQRTLRISHDALMANGDELNMQLKEQRlkccsLEKQLhsMKFSERRIEELQDRINDLEKERELLK 359
Cdd:COG4942    104 EELAEL------LRALYRLGRQPPLALLLSPEDFLDAVRRLQ-----YLKYL--APARREQAEELRADLAELAALRAELE 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  360 ENYDKLydsafsaaheeqwklkeQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQK 439
Cdd:COG4942    171 AERAEL-----------------EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLE 233

                   ....*....
gi 1034594131  440 QQLDELKKR 448
Cdd:COG4942    234 AEAAAAAER 242
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
273-477 2.36e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 60.93  E-value: 2.36e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  273 KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLhsmKFSERRIEELQDRINDLE 352
Cdd:COG4942     20 DAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQEL---AALEAELAELEKEIAELR 96
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  353 KERELLKENYDKLYDSAFSAAHEEQWKLK---------------EQQLKVQIAQLETALKSDLTDKTEILDRLKTERGAL 417
Cdd:COG4942     97 AELEAQKEELAELLRALYRLGRQPPLALLlspedfldavrrlqyLKYLAPARREQAEELRADLAELAALRAELEAERAEL 176
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034594131  418 INQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDI---NADELSEALLLIKAQKEQK 477
Cdd:COG4942    177 EALLAELEEERAALEALKAERQKLLARLEKELAELAAELAElqqEAEELEALIARLEAEAAAA 239
C2 pfam00168
C2 domain;
796-903 7.43e-09

C2 domain;


Pssm-ID: 425499 [Multi-domain]  Cd Length: 104  Bit Score: 54.63  E-value: 7.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  796 LHITIRCCNHLQSRASHLQPHPYV-VYKFFDFADHDTAIIPSSNDPQFDDHMYFPVPMNMDldrylksESLSFYVFDDSD 874
Cdd:pfam00168    3 LTVTVIEAKNLPPKDGNGTSDPYVkVYLLDGKQKKKTKVVKNTLNPVWNETFTFSVPDPEN-------AVLEIEVYDYDR 75
                           90       100
                   ....*....|....*....|....*....
gi 1034594131  875 TQENIYIGKVNVPLISLAHDRCISGIFEL 903
Cdd:pfam00168   76 FGRDDFIGEVRIPLSELDSGEGLDGWYPL 104
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
201-577 2.18e-08

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 58.63  E-value: 2.18e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLH-KQLVEKS 279
Cdd:COG4717     83 AEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERlEELRELE 162
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  280 NALSAMEGKFIQLQEKQRTLRISHDALMANgdelnmqlkeqrlkccSLEKQLHSMKFSERRIEELQDRINDLEKERELLK 359
Cdd:COG4717    163 EELEELEAELAELQEELEELLEQLSLATEE----------------ELQDLAEELEELQQRLAELEEELEEAQEELEELE 226
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  360 ENYDKLYDSAFSAAHEEQWKLKEQQLKV--QIAQLETALKSDLTDKTEILDRLKTERGALI-----NQNEKLVQENRELQ 432
Cdd:COG4717    227 EELEQLENELEAAALEERLKEARLLLLIaaALLALLGLGGSLLSLILTIAGVLFLVLGLLAllfllLAREKASLGKEAEE 306
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  433 LQYLEQKQQLD--ELKKRIKLYNQENDINADELSEALLLIKAQKEQkngdLSFLVKVDSEInkDLERSMRELQATHAETV 510
Cdd:COG4717    307 LQALPALEELEeeELEELLAALGLPPDLSPEELLELLDRIEELQEL----LREAEELEEEL--QLEELEQEIAALLAEAG 380
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034594131  511 QELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLqqDYELKVEQYVHLLDIRAARIHKLEAQLKDIA 577
Cdd:COG4717    381 VEDEEELRAALEQAEEYQELKEELEELEEQLEEL--LGELEELLEALDEEELEEELEELEEELEELE 445
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
211-573 5.07e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 57.49  E-value: 5.07e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  211 LENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQrsnirdnvemiKLHKQLVEKSNALSAMEGKFI 290
Cdd:pfam01576   73 LEEILHELESRLEEEEERSQQLQNEKKKMQQHIQDLEEQLDEEEAARQ-----------KLQLEKVTTEAKIKKLEEDIL 141
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  291 QLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSmkfSERRIEELQDRINDLEKERELLKENYDKLyDSAF 370
Cdd:pfam01576  142 LLEDQNSKLSKERKLLEERISEFTSNLAEEEEKAKSLSKLKNK---HEAMISDLEERLKKEEKGRQELEKAKRKL-EGES 217
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  371 SAAHEEQWKLKEQ--QLKVQIAQLETALKSdltdkteILDRLKTERGalinQNEKLVQENRELQLQYLEQKQQLD-ELKK 447
Cdd:pfam01576  218 TDLQEQIAELQAQiaELRAQLAKKEEELQA-------ALARLEEETA----QKNNALKKIRELEAQISELQEDLEsERAA 286
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  448 RIKLYNQENDINAD------ELSEALLLIKAQKE---QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE------ 512
Cdd:pfam01576  287 RNKAEKQRRDLGEElealktELEDTLDTTAAQQElrsKREQEVTELKKALEEETRSHEAQLQEMRQKHTQALEElteqle 366
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034594131  513 ---------------LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL 573
Cdd:pfam01576  367 qakrnkanlekakqaLESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSESERQRAELAEKLSKLQSEL 442
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
47-575 5.58e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 5.58e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   47 REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV-EMEEMIEQLQEKVHELEKQ 125
Cdd:TIGR02168  238 REELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEIsRLEQQKQILRERLANLERQ 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  126 NETLKNRLISAKQQLQTQGYR----QTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDAdvaetphpmftkygnsLL 201
Cdd:TIGR02168  318 LEELEAQLEELESKLDELAEElaelEEKLEELKEELESLEAELEELEAELEELESRLEELEE----------------QL 381
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  202 EEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMI------------ 269
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELeelqeelerlee 461
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  270 ---KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS---ERRIEE 343
Cdd:TIGR02168  462 aleELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDegyEAAIEA 541
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  344 -LQDRINDLEKER--------ELLKEN---------YDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALK-------- 397
Cdd:TIGR02168  542 aLGGRLQAVVVENlnaakkaiAFLKQNelgrvtflpLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKlrkalsyl 621
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  398 -------SDLTDKTEILDRLK------TERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIKLynQENDINA---- 460
Cdd:TIGR02168  622 lggvlvvDDLDNALELAKKLRpgyrivTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEE--LEEKIAEleka 699
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  461 -DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQaTHAETVQELEKTRNMLIMQHKINKDY----QMEVE 535
Cdd:TIGR02168  700 lAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVE-QLEERIAQLSKELTELEAEIEELEERleeaEEELA 778
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|
gi 1034594131  536 AVTRKMENLQQDyelkVEQYVHLLDIRAARIHKLEAQLKD 575
Cdd:TIGR02168  779 EAEAEIEELEAQ----IEQLKEELKALREALDELRAELTL 814
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
328-577 6.01e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.25  E-value: 6.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  328 EKQLHSMkfsERRIEELQDRINDLEKERELLK------ENYDKLydsafsaaheeQWKLKEQQLKVQIAQLETAlksdlt 401
Cdd:COG1196    178 ERKLEAT---EENLERLEDILGELERQLEPLErqaekaERYREL-----------KEELKELEAELLLLKLREL------ 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  402 dkTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIklynqendinaDELSEALLLIKAQKEQKNGDL 481
Cdd:COG1196    238 --EAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELEL-----------EEAQAEEYELLAELARLEQDI 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  482 SFLVKVDSEINKDLER---SMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 558
Cdd:COG1196    305 ARLEERRRELEERLEEleeELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEEL 384
                          250
                   ....*....|....*....
gi 1034594131  559 LDIRAARIHKLEAQLKDIA 577
Cdd:COG1196    385 AEELLEALRAAAELAAQLE 403
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
107-570 6.32e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 57.29  E-value: 6.32e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  107 EMEEMIEQLQEKVHELEKQNETL--KNRLISAKQQLQTQGYRQTP----YNNVQSRINTGRRKAN---ENAGLQECpRKG 177
Cdd:TIGR00618  230 HLREALQQTQQSHAYLTQKREAQeeQLKKQQLLKQLRARIEELRAqeavLEETQERINRARKAAPlaaHIKAVTQI-EQQ 308
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  178 IKFQDADVAETphpmftkygnsllEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQ--LRRKENEIELSLLQLREQQA 255
Cdd:TIGR00618  309 AQRIHTELQSK-------------MRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQeiHIRDAHEVATSIREISCQQH 375
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  256 TDqRSNIRDNVEMIKLhkqLVEKSNALSAMEGKFIQLQEKQRTLRISHDAL----MANGDELNMQLKEQRLKCCSLEKQL 331
Cdd:TIGR00618  376 TL-TQHIHTLQQQKTT---LTQKLQSLCKELDILQREQATIDTRTSAFRDLqgqlAHAKKQQELQQRYAELCAAAITCTA 451
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  332 HSMKFSERRIEELQDRInDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLk 411
Cdd:TIGR00618  452 QCEKLEKIHLQESAQSL-KEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNPGPLTRR- 529
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  412 TERGalinqneklvqENRELQLQYLEQK--QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDS 489
Cdd:TIGR00618  530 MQRG-----------EQTYAQLETSEEDvyHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQD 598
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  490 EINKDLERSMRELQATHAETVQELEKTRNMLIMQH--KINKDYQMEVEAVTRKMENLQQDyelkvEQYVHLLDIRAARIH 567
Cdd:TIGR00618  599 LTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHlqQCSQELALKLTALHALQLTLTQE-----RVREHALSIRVLPKE 673

                   ...
gi 1034594131  568 KLE 570
Cdd:TIGR00618  674 LLA 676
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
201-576 7.14e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 7.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEhlAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSN 280
Cdd:PRK03918   233 LEELKEEIEELEKELESLEGSKRKLE--EKIRELEERIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEEYLDELR 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKfiqLQEKQRTLRishdALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER---RIEELQDRINDLEKEREL 357
Cdd:PRK03918   311 EIEKRLSR---LEEEINGIE----ERIKELEEKEERLEELKKKLKELEKRLEELEERHElyeEAKAKKEELERLKKRLTG 383
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  358 L-KENYDKLYDSAFSAAHEEQWKLKE-----QQLKVQIAQLETAL-------------KSDLTDK---------TEILDR 409
Cdd:PRK03918   384 LtPEKLEKELEELEKAKEEIEEEISKitariGELKKEIKELKKAIeelkkakgkcpvcGRELTEEhrkelleeyTAELKR 463
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  410 LKTERGALINQNEKLVQENRELQ---------LQYLEQKQQLDELKKRIKLYNQENDINADELSEAL--LLIKAQKEQKN 478
Cdd:PRK03918   464 IEKELKEIEEKERKLRKELRELEkvlkkeselIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLkeKLIKLKGEIKS 543
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  479 gdlsflVKVDSEINKDLERSMRELQathaETVQELEKTRNMLImqHKINKDYQMEVEAVTRKMENLQQDYE--LKVEQYV 556
Cdd:PRK03918   544 ------LKKELEKLEELKKKLAELE----KKLDELEEELAELL--KELEELGFESVEELEERLKELEPFYNeyLELKDAE 611
                          410       420
                   ....*....|....*....|
gi 1034594131  557 HLLDIRAARIHKLEAQLKDI 576
Cdd:PRK03918   612 KELEREEKELKKLEEELDKA 631
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
48-573 7.27e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 57.00  E-value: 7.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   48 EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL-GRDVEMEEMIEQLQEKVHELEKQN 126
Cdd:PRK03918   203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLeEKIRELEERIEELKKEIEELEEKV 282
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  127 ETLKN---------RLISAKQQLQTQGYR--------QTPYNNVQSRINTGRRKANENAGLQEcPRKGIKfQDADVAETP 189
Cdd:PRK03918   283 KELKElkekaeeyiKLSEFYEEYLDELREiekrlsrlEEEINGIEERIKELEEKEERLEELKK-KLKELE-KRLEELEER 360
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  190 HpmftkygnSLLEEARGEIRNLENViqSQRGQIEELEHLAEILKTQLRRKEnEIELSLLQLREQQAT--DQRSNIRDNVE 267
Cdd:PRK03918   361 H--------ELYEEAKAKKEELERL--KKRLTGLTPEKLEKELEELEKAKE-EIEEEISKITARIGElkKEIKELKKAIE 429
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  268 MIKLHK----------------QLVEKSNA-LSAMEGKFIQLQEKQRTLRishdalmANGDELNMQLKEQR--LKCCSLE 328
Cdd:PRK03918   430 ELKKAKgkcpvcgrelteehrkELLEEYTAeLKRIEKELKEIEEKERKLR-------KELRELEKVLKKESelIKLKELA 502
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  329 KQLHSM--KFSERRIEELQDRindlEKERELLKENYDKLyDSAFSAAHEEQWKLKEqqLKVQIAQLETALKSDLTDKTEI 406
Cdd:PRK03918   503 EQLKELeeKLKKYNLEELEKK----AEEYEKLKEKLIKL-KGEIKSLKKELEKLEE--LKKKLAELEKKLDELEEELAEL 575
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  407 LDRLKTERGALINQNEKLVQENRELQLQYLEQK---QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNgdlSF 483
Cdd:PRK03918   576 LKELEELGFESVEELEERLKELEPFYNEYLELKdaeKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELE---EL 652
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  484 LVKVDSEINKDLERSMRELQATHA----------ETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYElKVE 553
Cdd:PRK03918   653 EKKYSEEEYEELREEYLELSRELAglraeleeleKRREEIKKTLEKLKEELEEREKAKKELEKLEKALERVEELRE-KVK 731
                          570       580
                   ....*....|....*....|.
gi 1034594131  554 QYVHLLDIRA-ARIHKLEAQL 573
Cdd:PRK03918   732 KYKALLKERAlSKVGEIASEI 752
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
229-576 1.02e-07

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 56.72  E-value: 1.02e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  229 AEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV-----------EM-IKLHKQLVEKSNALSAMEGKFIQLQEKQ 296
Cdd:pfam01576   12 EELQKVKERQQKAESELKELEKKHQQLCEEKNALQEQLqaetelcaeaeEMrARLAARKQELEEILHELESRLEEEEERS 91
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  297 RTLRISHDALMANGDELNMQLKE-----QRLKccsLEKQL--HSMKFSERRIEELQDRINDLEKERELLKEnydKLYDSA 369
Cdd:pfam01576   92 QQLQNEKKKMQQHIQDLEEQLDEeeaarQKLQ---LEKVTteAKIKKLEEDILLLEDQNSKLSKERKLLEE---RISEFT 165
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  370 FSAAHEEQWKLKEQQLKVQiaqlETALKSDLTdkteilDRLKTE---RGALINQNEKLVQENRELQLQYLEQKQQLDELk 446
Cdd:pfam01576  166 SNLAEEEEKAKSLSKLKNK----HEAMISDLE------ERLKKEekgRQELEKAKRKLEGESTDLQEQIAELQAQIAEL- 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  447 kRIKLYNQEndinaDELSEALLLIKAQKEQKNgdlsflvkvdseinkDLERSMRELQATHAETVQELEKTRNMLIMQHKI 526
Cdd:pfam01576  235 -RAQLAKKE-----EELQAALARLEEETAQKN---------------NALKKIRELEAQISELQEDLESERAARNKAEKQ 293
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  527 NKDYQMEVEAVTRKME------NLQQDYELKVEQYVHLLDiRA----ARIHklEAQLKDI 576
Cdd:pfam01576  294 RRDLGEELEALKTELEdtldttAAQQELRSKREQEVTELK-KAleeeTRSH--EAQLQEM 350
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
338-598 2.42e-07

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 55.31  E-value: 2.42e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  338 ERRIEELQDRINDLEKERELLKENYDKL---------YDSAFSAAHEEQWKLKE-QQLKVQIAQLETALKsDLTDKTEIL 407
Cdd:COG4913    609 RAKLAALEAELAELEEELAEAEERLEALeaeldalqeRREALQRLAEYSWDEIDvASAEREIAELEAELE-RLDASSDDL 687
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  408 DRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIK-LYNQENDINADELSEALLLIKAQKEQKNGDlsflvK 486
Cdd:COG4913    688 AALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDeLQDRLEAAEDLARLELRALLEERFAAALGD-----A 762
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  487 VDSEINKDLERSMRELQATHAETVQELEKTRnmlimqHKINKDYQMEVEAVT----------RKMENLQQD----YELK- 551
Cdd:COG4913    763 VERELRENLEERIDALRARLNRAEEELERAM------RAFNREWPAETADLDadleslpeylALLDRLEEDglpeYEERf 836
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034594131  552 -----------VEQYVHLLD--IRAA--RIHKLEAQLKDIAYGT-KQYKFKPEIMPDDSVDEF 598
Cdd:COG4913    837 kellnensiefVADLLSKLRraIREIkeRIDPLNDSLKRIPFGPgRYLRLEARPRPDPEVREF 899
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
206-508 3.55e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 54.69  E-value: 3.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  206 GEIRNLENVIQSQRGQIEELEhlAEILKTQLRRKENEIELsllqlreqqatdqrsnirdnVEMIKLHKQLVEKSNALSam 285
Cdd:TIGR02169  230 KEKEALERQKEAIERQLASLE--EELEKLTEEISELEKRL--------------------EEIEQLLEELNKKIKDLG-- 285
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  286 EGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKfseRRIEELQDRINDLEKERELLKENYDKL 365
Cdd:TIGR02169  286 EEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLL---AEIEELEREIEEERKRRDKLTEEYAEL 362
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  366 ydsafsaaheeqwKLKEQQLKVQIAQLET---ALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQL 442
Cdd:TIGR02169  363 -------------KEELEDLRAELEEVDKefaETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAI 429
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034594131  443 DELKKRIKLYNQENDINADELSEA---LLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE 508
Cdd:TIGR02169  430 AGIEAKINELEEEKEDKALEIKKQewkLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQ 498
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
114-481 3.62e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 3.62e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  114 QLQEKVHELEKQNETLKNRLISAKQQLQTQgyrQTPYNNVQSRINTGRRKANEnaglqecprkgIKFQDADvaetphpmf 193
Cdd:TIGR04523  215 SLESQISELKKQNNQLKDNIEKKQQEINEK---TTEISNTQTQLNQLKDEQNK-----------IKKQLSE--------- 271
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  194 tkyGNSLLEEARGEIRNLENVIQSQRGQIEEL-----EHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIR 263
Cdd:TIGR04523  272 ---KQKELEQNNKKIKELEKQLNQLKSEISDLnnqkeQDWNKELKSELKNQEKKLEEIQNQISQnnkiiSQLNEQISQLK 348
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  264 D-----NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDAL---MANGDELNmQLKEQRLKCCSLEKQLHS-- 333
Cdd:TIGR04523  349 KeltnsESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQINDLeskIQNQEKLN-QQKDEQIKKLQQEKELLEke 427
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  334 --------------MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKE--------QQLKVQIAQ 391
Cdd:TIGR04523  428 ierlketiiknnseIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIKQNLEQKQKElkskekelKKLNEEKKE 507
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  392 LETALK------SDLTDKTEILDRLKTERGALINQNEKLVqENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSE 465
Cdd:TIGR04523  508 LEEKVKdltkkiSSLKEKIEKLESEKKEKESKISDLEDEL-NKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEE 586
                          410
                   ....*....|....*.
gi 1034594131  466 ALLLIKaQKEQKNGDL 481
Cdd:TIGR04523  587 KQELID-QKEKEKKDL 601
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
201-467 1.42e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 53.00  E-value: 1.42e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLEnviqsqrgqiEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRdnvemIKLHKQLVEKSN 280
Cdd:COG4913    237 LERAHEALEDAR----------EQIELLEPIRELAERYAAARERLAELEYLRAALRLWFAQRR-----LELLEAELEELR 301
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAmegkfiQLQEKQRTLRISHDALMANGDELNMQLKEQRLkccslekqlhsmkfseRRIEELQDRINDLEKERELLKE 360
Cdd:COG4913    302 AELA------RLEAELERLEARLDALREELDELEAQIRGNGG----------------DRLEQLEREIERLERELEERER 359
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  361 NYDKlYDSAFSAAHEEqWKLKEQQLKVQIAQLETALksdlTDKTEILDRLKTERGALINQNEKLVQENRELQlqyleqkQ 440
Cdd:COG4913    360 RRAR-LEALLAALGLP-LPASAEEFAALRAEAAALL----EALEEELEALEEALAEAEAALRDLRRELRELE-------A 426
                          250       260
                   ....*....|....*....|....*..
gi 1034594131  441 QLDELKKRIKLYNQENDINADELSEAL 467
Cdd:COG4913    427 EIASLERRKSNIPARLLALRDALAEAL 453
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
107-435 2.67e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 52.04  E-value: 2.67e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVA 186
Cdd:pfam15921  549 ECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVS 628
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  187 --ETPHPMFTKYGNSLLEEARG---EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQrsn 261
Cdd:pfam15921  629 dlELEKVKLVNAGSERLRAVKDikqERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQ--- 705
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  262 irdnvemiklhKQLVEKSNALSAMEGkfiqlqekqrtlrishdalmANGDELNMQLKEQRlKCCSLEKQLHSMkfsERRI 341
Cdd:pfam15921  706 -----------SELEQTRNTLKSMEG--------------------SDGHAMKVAMGMQK-QITAKRGQIDAL---QSKI 750
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  342 EELQDRINDLEKERELLKENYDKLYDSAFSAAHE--------EQWKLKEQQLKVQIAQLETALKSDLTDKTEILDrlkte 413
Cdd:pfam15921  751 QFLEEAMTNANKEKHFLKEEKNKLSQELSTVATEknkmagelEVLRSQERRLKEKVANMEVALDKASLQFAECQD----- 825
                          330       340
                   ....*....|....*....|..
gi 1034594131  414 rgaLINQNEklvQENRELQLQY 435
Cdd:pfam15921  826 ---IIQRQE---QESVRLKLQH 841
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
107-576 6.21e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 50.81  E-value: 6.21e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTqgyrqtpynnvqsrINTGRRKANENAGLQECPRKGIKFQDADVA 186
Cdd:PRK02224   255 TLEAEIEDLRETIAETEREREELAEEVRDLRERLEE--------------LEEERDDLLAEAGLDDADAEAVEARREELE 320
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  187 ETphpmftkygnslLEEARGEIRNLENVIQSQRGQIE-------ELEHLAEILKTQLRRKENEIELSLLQLREQQA--TD 257
Cdd:PRK02224   321 DR------------DEELRDRLEECRVAAQAHNEEAEslredadDLEERAEELREEAAELESELEEAREAVEDRREeiEE 388
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  258 QRSNIRDN--------VEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRIS---HDALMANG---------------- 310
Cdd:PRK02224   389 LEEEIEELrerfgdapVDLGNAEDFLEELREERDELREREAELEATLRTARERveeAEALLEAGkcpecgqpvegsphve 468
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  311 ---------DELNMQLKEQRLKCCSLEK---QLHSMKFSERRIEELQDRINDLEK----ERELLKENYDKL--------- 365
Cdd:PRK02224   469 tieedrervEELEAELEDLEEEVEEVEErleRAEDLVEAEDRIERLEERREDLEEliaeRRETIEEKRERAeelreraae 548
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  366 YDSAFSAAHEEQWKLKEQQLKVQ--IAQLETALkSDLTDKTEILDRLKTeRGALINQNEKLVQENRE----LQLQYLEQK 439
Cdd:PRK02224   549 LEAEAEEKREAAAEAEEEAEEAReeVAELNSKL-AELKERIESLERIRT-LLAAIADAEDEIERLREkreaLAELNDERR 626
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  440 QQLDELKKRIKlyNQENDINADELSEAllliKAQKEQKNgdlSFLVKVDSEInKDLERSMRELQATHAETVQELEKTRNm 519
Cdd:PRK02224   627 ERLAEKRERKR--ELEAEFDEARIEEA----REDKERAE---EYLEQVEEKL-DELREERDDLQAEIGAVENELEELEE- 695
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034594131  520 LIMQHKINKDYQMEVEAVTRKMENLQQDY-ELKVEqyvhlldIRAARIHKLEAQLKDI 576
Cdd:PRK02224   696 LRERREALENRVEALEALYDEAEELESMYgDLRAE-------LRQRNVETLERMLNET 746
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
63-548 8.24e-06

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 8.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   63 LLKQHARKQEDKI--KRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL 140
Cdd:COG4717     46 MLLERLEKEADELfkPQGRKPELNLKELKELEEELKEAEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEKLL 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  141 QTQGYRQTP------YNNVQSRINTGRRKANENAGLQEcprkGIKFQDADVAETpHPMFTKYGNSLLEEARGEIRNLENV 214
Cdd:COG4717    126 QLLPLYQELealeaeLAELPERLEELEERLEELRELEE----ELEELEAELAEL-QEELEELLEQLSLATEEELQDLAEE 200
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  215 IQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQrsnIRDNVEMIKLHKQLVeksnALSAMEGKFIQLQE 294
Cdd:COG4717    201 LEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEER---LKEARLLLLIAAALL----ALLGLGGSLLSLIL 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  295 KQRTLRISHDALMANGDELNMQLKEQRLKccSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAfSAAH 374
Cdd:COG4717    274 TIAGVLFLVLGLLALLFLLLAREKASLGK--EAEELQALPALEELEEEELEELLAALGLPPDLSPEELLELLDRI-EELQ 350
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  375 EEQWKLKEQQLKVQIAQLETALKsdltdktEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIKlyNQ 454
Cdd:COG4717    351 ELLREAEELEEELQLEELEQEIA-------ALLAEAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELE--EL 421
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  455 ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEIN---KDLERSmRELQATHAEtVQELEKTRNMLIMQHKInkdYQ 531
Cdd:COG4717    422 LEALDEEELEEELEELEEELEELEEELEELREELAELEaelEQLEED-GELAELLQE-LEELKAELRELAEEWAA---LK 496
                          490
                   ....*....|....*..
gi 1034594131  532 MEVEAVTRKMENLQQDY 548
Cdd:COG4717    497 LALELLEEAREEYREER 513
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
201-455 1.17e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 1.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR-DNVEMIKLHKQLVEKS 279
Cdd:COG4913    619 LAELEEELAEAEERLEALEAELDALQERREALQRLAEYSWDEIDVASAEREIAELEAELERLDaSSDDLAALEEQLEELE 698
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  280 NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLkEQRLKCCSLEKQLHsmkFSERRIEELQDRI-----NDLEKE 354
Cdd:COG4913    699 AELEELEEELDELKGEIGRLEKELEQAEEELDELQDRL-EAAEDLARLELRAL---LEERFAAALGDAVerelrENLEER 774
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  355 RELLKENYDKLYDSAFSAAHE--EQWKLKEQQLKVQIAqletalksDLTDKTEILDRLKTERgaLINQNEKLVQENRELQ 432
Cdd:COG4913    775 IDALRARLNRAEEELERAMRAfnREWPAETADLDADLE--------SLPEYLALLDRLEEDG--LPEYEERFKELLNENS 844
                          250       260
                   ....*....|....*....|....*...
gi 1034594131  433 LQYLEQ-----KQQLDELKKRIKLYNQE 455
Cdd:COG4913    845 IEFVADllsklRRAIREIKERIDPLNDS 872
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
221-503 1.37e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 49.68  E-value: 1.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  221 QIEELEHLAEILKTQLRRKENEIElsllqlREQQATDQRSNIRDNVEMIKlhKQLVEKSNALSAMEGKFIQLQEKQRTLR 300
Cdd:PRK03918   156 GLDDYENAYKNLGEVIKEIKRRIE------RLEKFIKRTENIEELIKEKE--KELEEVLREINEISSELPELREELEKLE 227
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  301 ISHDALmangDELNMQLKEQRLKCCSLEKqlhSMKFSERRIEELQDRINDLEKERELLKENYDKL-----YDSAFSAAHE 375
Cdd:PRK03918   228 KEVKEL----EELKEEIEELEKELESLEG---SKRKLEEKIRELEERIEELKKEIEELEEKVKELkelkeKAEEYIKLSE 300
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  376 --EQWKLKEQQLKVQIAQLETALK------SDLTDKTEILDRLKTERGALINQNEKLvqENRELQLQYLEQKQ-QLDELK 446
Cdd:PRK03918   301 fyEEYLDELREIEKRLSRLEEEINgieeriKELEEKEERLEELKKKLKELEKRLEEL--EERHELYEEAKAKKeELERLK 378
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  447 KRIKLYNQEndinadELSEALLLIKAQKEQKNGDLSFLVKVDSEIN---KDLERSMRELQ 503
Cdd:PRK03918   379 KRLTGLTPE------KLEKELEELEKAKEEIEEEISKITARIGELKkeiKELKKAIEELK 432
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
341-582 1.51e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 49.68  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  341 IEELQDRINDLEKERElLKENYDKLydsafsaaheeQWKLKEQQLKVQIAQLETALKS------DLTDKTEILDRLKTER 414
Cdd:TIGR02169  193 IDEKRQQLERLRRERE-KAERYQAL-----------LKEKREYEGYELLKEKEALERQkeaierQLASLEEELEKLTEEI 260
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  415 GALINQNEKLVQENRELQLQ--------YLEQKQQLDELKKRIKLYNQENDINADELSEalllikAQKEQKNGDlSFLVK 486
Cdd:TIGR02169  261 SELEKRLEEIEQLLEELNKKikdlgeeeQLRVKEKIGELEAEIASLERSIAEKERELED------AEERLAKLE-AEIDK 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  487 VDSEInKDLERSMRELQATHA---ETVQELEKTRNMLIMQ-------HKI----NKDYQMEVEAVTRKMENLQQDY---- 548
Cdd:TIGR02169  334 LLAEI-EELEREIEEERKRRDkltEEYAELKEELEDLRAEleevdkeFAEtrdeLKDYREKLEKLKREINELKRELdrlq 412
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|
gi 1034594131  549 ELKVEQYVHLLDIRA------ARIHKLEAQLKDIAYGTKQ 582
Cdd:TIGR02169  413 EELQRLSEELADLNAaiagieAKINELEEEKEDKALEIKK 452
PLN02939 PLN02939
transferase, transferring glycosyl groups
148-515 1.86e-05

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 49.13  E-value: 1.86e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAetphpmftkygnslLEEARGEIRNLE-NVIQSQRGQIEELE 226
Cdd:PLN02939    91 TSSDDDHNRASMQRDEAIAAIDNEQQTNSKDGEQLSDFQ--------------LEDLVGMIQNAEkNILLLNQARLQALE 156
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  227 HLAEIL--KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRishd 304
Cdd:PLN02939   157 DLEKILteKEALQGKINILEMRLSETDARIKLAAQEKIHVEILEEQLEKLRNELLIRGATEGLCVHSLSKELDVLK---- 232
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  305 almangdELNMQLKEqrlkccslEKQLHSMKFSErrIEELQDRINDLEKERELLKENYDKLyDSAFSAAHEEQWKLKEQQ 384
Cdd:PLN02939   233 -------EENMLLKD--------DIQFLKAELIE--VAETEERVFKLEKERSLLDASLREL-ESKFIVAQEDVSKLSPLQ 294
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  385 LKVQIAQLETalksdLTDkteILDRLKtergaliNQNEK---LVQENRELqlqyleqKQQLDELKKRIKlynqenDINAD 461
Cdd:PLN02939   295 YDCWWEKVEN-----LQD---LLDRAT-------NQVEKaalVLDQNQDL-------RDKVDKLEASLK------EANVS 346
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034594131  462 ELSEALLLIKAQK----EQKngdlsfLVKVDSEINKDL---ERSMRELQATHAETVQELEK 515
Cdd:PLN02939   347 KFSSYKVELLQQKlkllEER------LQASDHEIHSYIqlyQESIKEFQDTLSKLKEESKK 401
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
37-600 1.95e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.16  E-value: 1.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERvgggpkrlgRDVEMEEMIEQLQ 116
Cdd:COG1196    252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEE---------RRRELEERLEELE 322
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  117 EKVHELEKQNETLKNRLISAKQQLQTQGYRQTpyNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETphpmftky 196
Cdd:COG1196    323 EELAELEEELEELEEELEELEEELEEAEEELE--EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL-------- 392
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  197 gnSLLEEARGEIRNLENVIQSQRGQIEELEHLAEilktQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV 276
Cdd:COG1196    393 --RAAAELAAQLEELEEAEEALLERLERLEEELE----ELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLA 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  277 EKSNALSAMEGKFIQLQEKQRTLRISHDALMAngDELNMQLKEQRLKccslekqlhsmkfsERRIEELQDRINDLEKERE 356
Cdd:COG1196    467 ELLEEAALLEAALAELLEELAEAAARLLLLLE--AEADYEGFLEGVK--------------AALLLAGLRGLAGAVAVLI 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  357 LLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTdkteiLDRLKTERGALINQNEKLVQENRELQLQYL 436
Cdd:COG1196    531 GVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRAT-----FLPLDKIRARAALAAALARGAIGAAVDLVA 605
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  437 EQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQkngdlsfLVKVDSEINKDLERSMRELQATHAETVQELEKT 516
Cdd:COG1196    606 SDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGR-------LREVTLEGEGGSAGGSLTGGSRRELLAALLEAE 678
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  517 RNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVD 596
Cdd:COG1196    679 AELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPE 758

                   ....
gi 1034594131  597 EFDE 600
Cdd:COG1196    759 PPDL 762
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
209-443 2.58e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.47  E-value: 2.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  209 RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIE-------LSLLQLREQQATDQRSNIRDnvemiklhkQLVEKSNA 281
Cdd:COG3206    164 QNLELRREEARKALEFLEEQLPELRKELEEAEAALEefrqkngLVDLSEEAKLLLQQLSELES---------QLAEARAE 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  282 LSAMEGKFIQLQEKQRTLRISHDALMAngDELNMQLKEQRLKccsLEKQLHSM--KFSER--RIEELQDRINDLekeREL 357
Cdd:COG3206    235 LAEAEARLAALRAQLGSGPDALPELLQ--SPVIQQLRAQLAE---LEAELAELsaRYTPNhpDVIALRAQIAAL---RAQ 306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  358 LKENYDKLYDSAFSAAheEQWKLKEQQLKVQIAQLETALKSdLTDKTEILDRLKTErgalinqneklVQENRELQLQYLE 437
Cdd:COG3206    307 LQQEAQRILASLEAEL--EALQAREASLQAQLAQLEARLAE-LPELEAELRRLERE-----------VEVARELYESLLQ 372

                   ....*.
gi 1034594131  438 QKQQLD 443
Cdd:COG3206    373 RLEEAR 378
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
335-566 2.63e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.47  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  335 KFSERRIEELQDRINDLEKERELLKENYDkLYDSafsaahEEQWKLKEQQLkVQIAQLETALKSDLTDKTEILDRLKTER 414
Cdd:COG3206    178 EFLEEQLPELRKELEEAEAALEEFRQKNG-LVDL------SEEAKLLLQQL-SELESQLAEARAELAEAEARLAALRAQL 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  415 GALINQNEKLVQ--ENRELQLQYLEQKQQLDELKKRiklYNQENDInadelsealllIKAQKEQKNGDLSFLVKVDSEIN 492
Cdd:COG3206    250 GSGPDALPELLQspVIQQLRAQLAELEAELAELSAR---YTPNHPD-----------VIALRAQIAALRAQLQQEAQRIL 315
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034594131  493 KDLERSMRELQATHAETVQELEKTRNMLimqhkinkdyqMEVEAVTRKMENLQQDYELKVEQYVHLLD-IRAARI 566
Cdd:COG3206    316 ASLEAELEALQAREASLQAQLAQLEARL-----------AELPELEAELRRLEREVEVARELYESLLQrLEEARL 379
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
39-375 2.87e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 48.53  E-value: 2.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   39 RQAVSRVSRE--ELEDRFLRLHDE----NILLKQHARKQ---EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEME 109
Cdd:TIGR02169  708 SQELSDASRKigEIEKEIEQLEQEeeklKERLEELEEDLsslEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEAR 787
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  110 EMIEQLQEKVHELEKQNETLKN---RLISAKQQLQTQGYR----QTPYNNVQSRINTGRRKANENaglqecpRKGIKFQD 182
Cdd:TIGR02169  788 LSHSRIPEIQAELSKLEEEVSRieaRLREIEQKLNRLTLEkeylEKEIQELQEQRIDLKEQIKSI-------EKEIENLN 860
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  183 ADVAETphpmftkygNSLLEEARGEIRNLENVIQSQRGQIEELEhlAEIlkTQLRRKENEIELSLLQLREQQA--TDQRS 260
Cdd:TIGR02169  861 GKKEEL---------EEELEELEAALRDLESRLGDLKKERDELE--AQL--RELERKIEELEAQIEKKRKRLSelKAKLE 927
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  261 NIRDNVEMI-KLHKQLVEKSNALSAMEGKFIQLQEKQRtlrishdALMANGDeLNMQLKEQrlkccslekqlhsMKFSER 339
Cdd:TIGR02169  928 ALEEELSEIeDPKGEDEEIPEEELSLEDVQAELQRVEE-------EIRALEP-VNMLAIQE-------------YEEVLK 986
                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1034594131  340 RIEELQDRINDLEKERELLK---ENYDKLYDSAFSAAHE 375
Cdd:TIGR02169  987 RLDELKEKRAKLEEERKAILeriEEYEKKKREVFMEAFE 1025
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
201-365 2.89e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 48.47  E-value: 2.89e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIR---------NLENVIQSQRGQIEELEhlAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKL 271
Cdd:COG3206    191 LEEAEAALEefrqknglvDLSEEAKLLLQQLSELE--SQLAEARAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQL 268
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  272 HKQLVEKSNALSAMEGKF-------IQLQEKQRTLRISHDALMANG-DELNMQLKEQRLKCCSLEKQLHSMKFSERRIEE 343
Cdd:COG3206    269 RAQLAELEAELAELSARYtpnhpdvIALRAQIAALRAQLQQEAQRIlASLEAELEALQAREASLQAQLAQLEARLAELPE 348
                          170       180
                   ....*....|....*....|..
gi 1034594131  344 LQDRINDLEKERELLKENYDKL 365
Cdd:COG3206    349 LEAELRRLEREVEVARELYESL 370
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
225-590 3.13e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 3.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  225 LEHLAEILKTQLRRKEneielSLLQLREQQA-----TDQRSNIRDNVEMIKLHKQLVEKSNALSAmegkfiQLQEKQRTL 299
Cdd:TIGR02168  161 FEEAAGISKYKERRKE-----TERKLERTREnldrlEDILNELERQLKSLERQAEKAERYKELKA------ELRELELAL 229
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  300 RISH-DALMANGDELNMQLKEQRLKCCSLEKQLHSmkfSERRIEELQDRINDLEKERELLKENYdklydsafsaaheeqw 378
Cdd:TIGR02168  230 LVLRlEELREELEELQEELKEAEEELEELTAELQE---LEEKLEELRLEVSELEEEIEELQKEL---------------- 290
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  379 klkeQQLKVQIAQLETalksdltDKTEILDRLktergalinqnEKLVQENRELQLQYLEQKQQLDELKKRI-----KLYN 453
Cdd:TIGR02168  291 ----YALANEISRLEQ-------QKQILRERL-----------ANLERQLEELEAQLEELESKLDELAEELaeleeKLEE 348
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  454 QENDINA--DELSEALLLIKAQK----------EQKNGDLSFLVKVDSEINKDLER---SMRELQATHAETVQELEKTRN 518
Cdd:TIGR02168  349 LKEELESleAELEELEAELEELEsrleeleeqlETLRSKVAQLELQIASLNNEIERleaRLERLEDRRERLQQEIEELLK 428
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034594131  519 MLIMQHKinKDYQMEVEAVTRKMENLQQDYELKVEQyvhlLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIM 590
Cdd:TIGR02168  429 KLEEAEL--KELQAELEELEEELEELQEELERLEEA----LEELREELEEAEQALDAAERELAQLQARLDSL 494
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
221-508 3.66e-05

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 440951 [Multi-domain]  Cd Length: 297  Bit Score: 47.21  E-value: 3.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  221 QIEELEHLAEILKT---QLRRKENEIELSLLQLREQqatdqrsniRDnvemiKLHKQLVEKSNALSAMEGKFIQLQEKQR 297
Cdd:COG1340      9 SLEELEEKIEELREeieELKEKRDELNEELKELAEK---------RD-----ELNAQVKELREEAQELREKRDELNEKVK 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  298 TLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRIN----DLEKERELLkenydklydsafsaa 373
Cdd:COG1340     75 ELKEERDELNEKLNELREELDELRKELAELNKAGGSIDKLRKEIERLEWRQQtevlSPEEEKELV--------------- 139
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  374 heEQWKLKEQQLKVQIAQLEtaLKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYN 453
Cdd:COG1340    140 --EKIKELEKELEKAKKALE--KNEKLKELRAELKELRKEAEEIHKKIKELAEEAQELHEEMIELYKEADELRKEADELH 215
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034594131  454 QEND---INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE 508
Cdd:COG1340    216 KEIVeaqEKADELHEEIIELQKELRELRKELKKLRKKQRALKREKEKEELEEKAEEIF 273
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
200-573 3.76e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 48.18  E-value: 3.76e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  200 LLEEARGEIRNLENVIQSQ----RGQIEELEHLA---EILKTQLRR-----KENEIELSLLQLREQQATDQRSnirdnVE 267
Cdd:pfam05483  262 LLEESRDKANQLEEKTKLQdenlKELIEKKDHLTkelEDIKMSLQRsmstqKALEEDLQIATKTICQLTEEKE-----AQ 336
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  268 MIKLHKQLVEKSNALSAMEGKFIQLQEkqrTLRISHDALMANGDELNMQLKEQRLKCCSLEKQlhsMKFSERRIEELQDR 347
Cdd:pfam05483  337 MEELNKAKAAHSFVVTEFEATTCSLEE---LLRTEQQRLEKNEDQLKIITMELQKKSSELEEM---TKFKNNKEVELEEL 410
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  348 INDLEKERELLKEN--YDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE-TALKSDLTDKTEILDRLKTERGALINQNEKL 424
Cdd:pfam05483  411 KKILAEDEKLLDEKkqFEKIAEELKGKEQELIFLLQAREKEIHDLEIQlTAIKTSEEHYLKEVEDLKTELEKEKLKNIEL 490
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  425 VQENRELQLQYLEQKQQLDELKkrIKLYNQENDINADELSEALLL-----IKAQKEQKNGDLSF----LVKVDSEINKDL 495
Cdd:pfam05483  491 TAHCDKLLLENKELTQEASDMT--LELKKHQEDIINCKKQEERMLkqienLEEKEMNLRDELESvreeFIQKGDEVKCKL 568
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  496 ERSMRELQATHAETvqeLEKTRNMLIMQHKINkDYQMEVEAVTRKMENLQQD---YELKVEQYVHLLDIRAARIHKLEAQ 572
Cdd:pfam05483  569 DKSEENARSIEYEV---LKKEKQMKILENKCN-NLKKQIENKNKNIEELHQEnkaLKKKGSAENKQLNAYEIKVNKLELE 644

                   .
gi 1034594131  573 L 573
Cdd:pfam05483  645 L 645
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
208-464 3.80e-05

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 47.89  E-value: 3.80e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  208 IRNLENVIQSQRGQIEELEHLAEILKTQ--------------LRRKENEIElsllQLREQQATDQRSNIRDNVEMIKLHK 273
Cdd:pfam10174  403 IENLQEQLRDKDKQLAGLKERVKSLQTDssntdtalttleeaLSEKERIIE----RLKEQREREDRERLEELESLKKENK 478
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  274 QLVEKSNAL----SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL---HSMKFSERRIEELQD 346
Cdd:pfam10174  479 DLKEKVSALqpelTEKESSLIDLKEHASSLASSGLKKDSKLKSLEIAVEQKKEECSKLENQLkkaHNAEEAVRTNPEIND 558
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  347 RINDLEKERELLKE-------NYDKLYDSAFSAAHEEQWKLKeqqlkvQIAQLETALKSDLTDKTEILDRLKTERGALIN 419
Cdd:pfam10174  559 RIRLLEQEVARYKEesgkaqaEVERLLGILREVENEKNDKDK------KIAELESLTLRQMKEQNKKVANIKHGQQEMKK 632
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1034594131  420 QNEKLVQENRELQLQYLE--QKQQLDELKKRIKLYNQENDINADELS 464
Cdd:pfam10174  633 KGAQLLEEARRREDNLADnsQQLQLEELMGALEKTRQELDATKARLS 679
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
191-537 3.85e-05

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 48.04  E-value: 3.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  191 PMFTKYGNSLLEEARGEIRNLENVIQSQR-----GQIEELEHLAEILKTQLRRK--ENEIELSLLQLREQQATDQRSNIR 263
Cdd:TIGR00618  601 EKLSEAEDMLACEQHALLRKLQPEQDLQDvrlhlQQCSQELALKLTALHALQLTltQERVREHALSIRVLPKELLASRQL 680
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  264 DNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR--------ISHDA---LMANGDELNMQLKE----QRLKCCSLE 328
Cdd:TIGR00618  681 ALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDrefneienASSSLgsdLAAREDALNQSLKElmhqARTVLKART 760
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  329 KQlHSMKFSERRIE-----ELQDRINDLEKERELLKENYdklydsafsaaheeqwklkeQQLKVQIAQLETALKSDLTDK 403
Cdd:TIGR00618  761 EA-HFNNNEEVTAAlqtgaELSHLAAEIQFFNRLREEDT--------------------HLLKTLEAEIGQEIPSDEDIL 819
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  404 TEILDRLKTERGALINQNEKLVQ---ENRELQLQYLEQKQQLDELKKRIKLYNQendinadeLSEALLLIKAQKEQKNGD 480
Cdd:TIGR00618  820 NLQCETLVQEEEQFLSRLEEKSAtlgEITHQLLKYEECSKQLAQLTQEQAKIIQ--------LSDKLNGINQIKIQFDGD 891
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034594131  481 LsfLVKVDSEINKDLERSMRELQATHAETVQELektrnmlimQHKINKDYQMEVEAV 537
Cdd:TIGR00618  892 A--LIKFLHEITLYANVRLANQSEGRFHGRYAD---------SHVNARKYQGLALLV 937
HEC1 COG5185
Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell ...
204-554 3.98e-05

Chromosome segregation protein NDC80, interacts with SMC proteins [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444066 [Multi-domain]  Cd Length: 594  Bit Score: 48.03  E-value: 3.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  204 ARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLRE---QQATDQRSNIR-----DNVEMIKLHKQl 275
Cdd:COG5185    204 VNSIKESETGNLGSESTLLEKAKEIINIEEALKGFQDPESELEDLAQTSdklEKLVEQNTDLRleklgENAESSKRLNE- 282
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  276 vEKSNALSAMEGKFIQLQEKQRTLRISHDAlmangDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER 355
Cdd:COG5185    283 -NANNLIKQFENTKEKIAEYTKSIDIKKAT-----ESLEEQLAAAEAEQELEESKRETETGIQNLTAEIEQGQESLTENL 356
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  356 ELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQY 435
Cdd:COG5185    357 EAIKEEIENIVGEVELSKSSEELDSFKDTIESTKESLDEIPQNQRGYAQEILATLEDTLKAADRQIEELQRQIEQATSSN 436
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  436 LEQKQQLDELKKRIKLYNQENDINADElsealLLIKAQKEQKNGDLSFLVKVDSEINKdLERSMRELQAT----HAETVQ 511
Cdd:COG5185    437 EEVSKLLNELISELNKVMREADEESQS-----RLEEAYDEINRSVRSKKEDLNEELTQ-IESRVSTLKATleklRAKLER 510
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 1034594131  512 ELEKTRNMLIMQHKINKDYQMEVE-AVTRKMENLQQDYELKVEQ 554
Cdd:COG5185    511 QLEGVRSKLDQVAESLKDFMRARGyAHILALENLIPASELIQAS 554
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
201-450 6.41e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 47.37  E-value: 6.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElsllQLREQQATDQRSNIRDNVEMIKLHKQLVEKSN 280
Cdd:TIGR02169  296 IGELEAEIASLERSIAEKERELEDAEERLAKLEAEIDKLLAEIE----ELEREIEEERKRRDKLTEEYAELKEELEDLRA 371
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALmanGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKEREllke 360
Cdd:TIGR02169  372 ELEEVDKEFAETRDELKDYREKLEKL---KREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKE---- 444
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  361 nydklydsafsAAHEEQWKlKEQQLKVQIAQLETAlKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQ 440
Cdd:TIGR02169  445 -----------DKALEIKK-QEWKLEQLAADLSKY-EQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRGGRA 511
                          250
                   ....*....|
gi 1034594131  441 QLDELKKRIK 450
Cdd:TIGR02169  512 VEEVLKASIQ 521
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
223-592 7.05e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.02  E-value: 7.05e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  223 EELEHLAEILKTQLRRKENEIELSLLQLREQQAT---------DQRSNIRDNVEMIKLH----KQLVEKSNAL-SAMEGK 288
Cdd:pfam05483  222 EKIQHLEEEYKKEINDKEKQVSLLLIQITEKENKmkdltflleESRDKANQLEEKTKLQdenlKELIEKKDHLtKELEDI 301
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  289 FIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSerrIEELQDRINDLEkerELLKENYDKLYDS 368
Cdd:pfam05483  302 KMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFV---VTEFEATTCSLE---ELLRTEQQRLEKN 375
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  369 afsaahEEQWKLKEQQLKVQIAQLETALKsdLTDKTEI-LDRLKTergaLINQNEKLVQENRELQLQYLEQKQQLDEL-- 445
Cdd:pfam05483  376 ------EDQLKIITMELQKKSSELEEMTK--FKNNKEVeLEELKK----ILAEDEKLLDEKKQFEKIAEELKGKEQELif 443
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  446 ---KKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD-LERSMRELQATHAETVQELEKTRNMLI 521
Cdd:pfam05483  444 llqAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDkLLLENKELTQEASDMTLELKKHQEDII 523
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034594131  522 MQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPD 592
Cdd:pfam05483  524 NCKKQEERMLKQIENLEEKEMNLRDELESVREEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILEN 594
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell ...
244-444 7.85e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442330 [Multi-domain]  Cd Length: 1470  Bit Score: 47.25  E-value: 7.85e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  244 ELSLLQLREQQATDQRSNIRDNVEMIKLHK-------QLVEKSNALSAMEGKFIQLQEKQRTLRiSHDALMANGDELNMQ 316
Cdd:COG3096    442 YLAAFRAKEQQATEEVLELEQKLSVADAARrqfekayELVCKIAGEVERSQAWQTARELLRRYR-SQQALAQRLQQLRAQ 520
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  317 LKEqrlkccsLEKQLHSMKFSERRIEELQDRIN-------DLEKERELLKENYDKLYDSAfSAAHEEQWKLKEQ--QLKV 387
Cdd:COG3096    521 LAE-------LEQRLRQQQNAERLLEEFCQRIGqqldaaeELEELLAELEAQLEELEEQA-AEAVEQRSELRQQleQLRA 592
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034594131  388 QIAQLET------ALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQL---QYLEQKQQLDE 444
Cdd:COG3096    593 RIKELAArapawlAAQDALERLREQSGEALADSQEVTAAMQQLLEREREATVerdELAARKQALES 658
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
107-520 8.14e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 47.04  E-value: 8.14e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGyrqtpyNNVQSRINTGRRKANENAGLQECprkgikfQDADVA 186
Cdd:pfam15921  257 KIELLLQQHQDRIEQLISEHEVEITGLTEKASSARSQA------NSIQSQLEIIQEQARNQNSMYMR-------QLSDLE 323
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  187 ETphpmftkygnslLEEARGEIRNLENVIQSQrgqIEELEHLAEILKTQLRRKENEielsllqlrEQQATDQRSNIRDNV 266
Cdd:pfam15921  324 ST------------VSQLRSELREAKRMYEDK---IEELEKQLVLANSELTEARTE---------RDQFSQESGNLDDQL 379
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  267 E--MIKLHKQlvEKSNALSAMEGKfiQLQEKQRTLRISHDALMANGDELNMQ-------LKEQRLKC-CSLEKQLHSMKF 336
Cdd:pfam15921  380 QklLADLHKR--EKELSLEKEQNK--RLWDRDTGNSITIDHLRRELDDRNMEvqrlealLKAMKSECqGQMERQMAAIQG 455
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  337 SERRIEELQDRINDLEKERELLKENYDKLY-----------------------DSAFSAAHEEQWKLKE---------QQ 384
Cdd:pfam15921  456 KNESLEKVSSLTAQLESTKEMLRKVVEELTakkmtlessertvsdltaslqekERAIEATNAEITKLRSrvdlklqelQH 535
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  385 LK-----VQIAQLET-ALKSDLTDKTEILDRLKTE--------------RGALINQNEKLVQE--NRELQLQYLE----- 437
Cdd:pfam15921  536 LKnegdhLRNVQTECeALKLQMAEKDKVIEILRQQienmtqlvgqhgrtAGAMQVEKAQLEKEinDRRLELQEFKilkdk 615
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  438 QKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEIN-----------------KDLERSMR 500
Cdd:pfam15921  616 KDAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNslsedyevlkrnfrnksEEMETTTN 695
                          490       500
                   ....*....|....*....|
gi 1034594131  501 ELQATHAETVQELEKTRNML 520
Cdd:pfam15921  696 KLKMQLKSAQSELEQTRNTL 715
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
339-518 9.62e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 9.62e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  339 RRIEELQDRINDLEKERELLkenydklyDSAFSAAHEEQWKLKEQQLKVQIAQLETA---LKSDLTDKTEILDRLKTERG 415
Cdd:COG4913    262 ERYAAARERLAELEYLRAAL--------RLWFAQRRLELLEAELEELRAELARLEAElerLEARLDALREELDELEAQIR 333
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  416 ALINQN-EKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 494
Cdd:COG4913    334 GNGGDRlEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLEALEEELEALEEALAEAEAA 413
                          170       180
                   ....*....|....*....|....
gi 1034594131  495 LERSMRELQATHAEtVQELEKTRN 518
Cdd:COG4913    414 LRDLRRELRELEAE-IASLERRKS 436
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
398-573 9.77e-05

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 46.36  E-value: 9.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  398 SDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIK--AQKE 475
Cdd:COG3883     16 PQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIDKLQAEIAEAEAEIEERREELGerARAL 95
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  476 QKNGD----LSFLVKVDSeINKDLERS--MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE 549
Cdd:COG3883     96 YRSGGsvsyLDVLLGSES-FSDFLDRLsaLSKIADADADLLEELKADKAELEAKKAELEAKLAELEALKAELEAAKAELE 174
                          170       180
                   ....*....|....*....|....
gi 1034594131  550 LKVEQYVHLLDIRAARIHKLEAQL 573
Cdd:COG3883    175 AQQAEQEALLAQLSAEEAAAEAQL 198
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
109-321 1.80e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 45.53  E-value: 1.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  109 EEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQ----GYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDAD 184
Cdd:COG4942     26 EAELEQLQQEIAELEKELAALKKEEKALLKQLAALerriAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEE 105
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  185 VAE----------TPHPMFTKYGNSLLEEARGeIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElSLLQLREQQ 254
Cdd:COG4942    106 LAEllralyrlgrQPPLALLLSPEDFLDAVRR-LQYLKYLAPARREQAEELRADLAELAALRAELEAERA-ELEALLAEL 183
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034594131  255 ATDQRsnirdnvemiKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
Cdd:COG4942    184 EEERA----------ALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAA 240
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
312-605 1.90e-04

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 46.20  E-value: 1.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  312 ELNMQLKEQRLKCCSLEKQLHSMKFSERRIE-----------ELQDRINDLEKERELLKENYD-KLYDSAFSAAHEEQWK 379
Cdd:TIGR01612  562 EIKKELEEENEDSIHLEKEIKDLFDKYLEIDdeiiyinklklELKEKIKNISDKNEYIKKAIDlKKIIENNNAYIDELAK 641
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  380 LKEQQLKVQIAQLETALKsdlTDKTEILDRLKTERGALINQNEKLVQENrelQLQYLEQKQQLDELKKRI-KLYNQENDI 458
Cdd:TIGR01612  642 ISPYQVPEHLKNKDKIYS---TIKSELSKIYEDDIDALYNELSSIVKEN---AIDNTEDKAKLDDLKSKIdKEYDKIQNM 715
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  459 NADELSEALLLIkaqKEQKNGDLSFLVKVD----SEINKDLERSMRELQATHAE---TVQELEKTRNML-IMQHKINK-- 528
Cdd:TIGR01612  716 ETATVELHLSNI---ENKKNELLDIIVEIKkhihGEINKDLNKILEDFKNKEKElsnKINDYAKEKDELnKYKSKISEik 792
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034594131  529 -DYQMEVEAVTRKMENLQQDYElKVEQYVHLLDIRAARIHKLEAQLKDiaygtkqykfkpeiMPDDSVDEFDETIHLE 605
Cdd:TIGR01612  793 nHYNDQINIDNIKDEDAKQNYD-KSKEYIKTISIKEDEIFKIINEMKF--------------MKDDFLNKVDKFINFE 855
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
311-512 2.50e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 44.82  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  311 DELNMQLKEQRLKCCSLEKQLHSMkfsERRIEELQDRINDLEKERELLKENYDKLYDSAfsAAHEEQWKLKEQQLKVQIA 390
Cdd:COG3883     19 QAKQKELSELQAELEAAQAELDAL---QAELEELNEEYNELQAELEALQAEIDKLQAEI--AEAEAEIEERREELGERAR 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  391 Q----------LETALKSdlTDKTEILDRLKTeRGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIKLynqendiNA 460
Cdd:COG3883     94 AlyrsggsvsyLDVLLGS--ESFSDFLDRLSA-LSKIADADADLLEELKADKAELEAKKAELEAKLAELEA-------LK 163
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034594131  461 DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE 512
Cdd:COG3883    164 AELEAAKAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
372-517 2.79e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 43.76  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  372 AAHEEQWKLKE-QQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLvqenRELQLQYLEQKQQLDELKKRIK 450
Cdd:COG1579      1 AMPEDLRALLDlQELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTEL----EDLEKEIKRLELEIEEVEARIK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  451 LYNQ-------ENDINA------------DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQ 511
Cdd:COG1579     77 KYEEqlgnvrnNKEYEAlqkeieslkrriSDLEDEILELMERIEELEEELAELEAELAELEAELEEKKAELDEELAELEA 156

                   ....*.
gi 1034594131  512 ELEKTR 517
Cdd:COG1579    157 ELEELE 162
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
48-453 5.28e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 44.37  E-value: 5.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   48 EELEDRFLRLHDenilLKQHARKQEDKIKRMATKLIRLVNDKkryervggGPKRLGRDVEMEEMIEQLQEKVHELEKQNE 127
Cdd:COG4717    149 EELEERLEELRE----LEEELEELEAELAELQEELEELLEQL--------SLATEEELQDLAEELEELQQRLAELEEELE 216
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  128 TLKNRLISAKQQLQtQGYRQTPYNNVQSRINTGRRKANENAGLqeCPRKGIKFQDADVAETPHPMFTKYGnSLLEEARGE 207
Cdd:COG4717    217 EAQEELEELEEELE-QLENELEAAALEERLKEARLLLLIAAAL--LALLGLGGSLLSLILTIAGVLFLVL-GLLALLFLL 292
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  208 IRNLENVIQSQRGQIEELEHLAEILKTQLRRkeneielsLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALsameg 287
Cdd:COG4717    293 LAREKASLGKEAEELQALPALEELEEEELEE--------LLAALGLPPDLSPEELLELLDRIEELQELLREAEEL----- 359
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  288 kfiqlqEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKfseRRIEELQDRINDLEKERELLKENYDklyd 367
Cdd:COG4717    360 ------EEELQLEELEQEIAALLAEAGVEDEEELRAALEQAEEYQELK---EELEELEEQLEELLGELEELLEALD---- 426
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  368 safsaahEEQWKLKEQQLKVQIAQLETAlksdltdkteiLDRLKTERGALINQNEKLVQENR--ELQLQYLEQKQQLDEL 445
Cdd:COG4717    427 -------EEELEEELEELEEELEELEEE-----------LEELREELAELEAELEQLEEDGElaELLQELEELKAELREL 488

                   ....*...
gi 1034594131  446 KKRIKLYN 453
Cdd:COG4717    489 AEEWAALK 496
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
198-360 5.93e-04

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.99  E-value: 5.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  198 NSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElsllQLREQQATDQR--SNIRDNVEMIKLHKQL 275
Cdd:COG1579     23 EHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIE----EVEARIKKYEEqlGNVRNNKEYEALQKEI 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  276 VEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEqrlkccsLEKQLhsmkfsERRIEELQDRINDLEKER 355
Cdd:COG1579     99 ESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEE-------KKAEL------DEELAELEAELEELEAER 165

                   ....*
gi 1034594131  356 ELLKE 360
Cdd:COG1579    166 EELAA 170
C2A_Tricalbin-like cd04044
C2 domain first repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are ...
796-920 7.28e-04

C2 domain first repeat present in Tricalbin-like proteins; 5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology.


Pssm-ID: 176009 [Multi-domain]  Cd Length: 124  Bit Score: 40.62  E-value: 7.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  796 LHITIRCCNHLQSRASHLQ-PHPYVVYKFFDFADHD-TAIIPSSNDPQFDDHMYFPVpmNMDldrylkSESLSFYVFDDS 873
Cdd:cd04044      4 LAVTIKSARGLKGSDIIGGtVDPYVTFSISNRRELArTKVKKDTSNPVWNETKYILV--NSL------TEPLNLTVYDFN 75
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1034594131  874 DTQENIYIGKVNVPLISLAHDRCISGI-FELTDHQKhPAGTIHVILKW 920
Cdd:cd04044     76 DKRKDKLIGTAEFDLSSLLQNPEQENLtKNLLRNGK-PVGELNYDLRF 122
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
49-520 7.37e-04

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 44.01  E-value: 7.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   49 ELEDRFLRLHDENILLKQHARKQEDKIKRMATKL--------------------IRLVNDK-KRYERVGGGPKRLGRDVE 107
Cdd:pfam01576  135 KLEEDILLLEDQNSKLSKERKLLEERISEFTSNLaeeeekakslsklknkheamISDLEERlKKEEKGRQELEKAKRKLE 214
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  108 MEemIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYR----QTPYNNVQSRIntgRRKANENAGLQEcprkgikfqDA 183
Cdd:pfam01576  215 GE--STDLQEQIAELQAQIAELRAQLAKKEEELQAALARleeeTAQKNNALKKI---RELEAQISELQE---------DL 280
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  184 DVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE-------ELEHLAEILKTQLRRKENEIElsllQLReQQAT 256
Cdd:pfam01576  281 ESERAARNKAEKQRRDLGEELEALKTELEDTLDTTAAQQElrskreqEVTELKKALEEETRSHEAQLQ----EMR-QKHT 355
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  257 DQRSNIRDNVEMIKLHKQLVEKSNAlsAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSlekqlhsmkf 336
Cdd:pfam01576  356 QALEELTEQLEQAKRNKANLEKAKQ--ALESENAELQAELRTLQQAKQDSEHKRKKLEGQLQELQARLSE---------- 423
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  337 SERRIEELQDRINDLEKERELLKENYDKLyDSAFSAAHEEQWKLKEQQLKVQ-IAQLETALKSDLTDKteiLDRLKTERG 415
Cdd:pfam01576  424 SERQRAELAEKLSKLQSELESVSSLLNEA-EGKNIKLSKDVSSLESQLQDTQeLLQEETRQKLNLSTR---LRQLEDERN 499
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  416 ALINQNEKLVQENRELQLQYLEQKQQLDELKKRIklynqendinadelsealllikaqkEQKNGDLSFLVKVDSEINKDL 495
Cdd:pfam01576  500 SLQEQLEEEEEAKRNVERQLSTLQAQLSDMKKKL-------------------------EEDAGTLEALEEGKKRLQREL 554
                          490       500
                   ....*....|....*....|....*
gi 1034594131  496 ERSMRELQaTHAETVQELEKTRNML 520
Cdd:pfam01576  555 EALTQQLE-EKAAAYDKLEKTKNRL 578
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
271-456 8.20e-04

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 43.26  E-value: 8.20e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  271 LHKQLVEKSNALSAMEGKFIQlQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHS----MKFSERRIEELQD 346
Cdd:pfam15905  127 LEKQLLELTRVNELLKAKFSE-DGTQKKMSSLSMELMKLRNKLEAKMKEVMAKQEGMEGKLQVtqknLEHSKGKVAQLEE 205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  347 RINDLEKERELLKENYDKL--YDSAFSAAHE--EQWKLKEQQLKVQIAQLET---ALKSDLTDKTEILDRLKTERGA--- 416
Cdd:pfam15905  206 KLVSTEKEKIEEKSETEKLleYITELSCVSEqvEKYKLDIAQLEELLKEKNDeieSLKQSLEEKEQELSKQIKDLNEkck 285
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 1034594131  417 -LINQNEKLVQENRELQLQYleqKQQLDELKKRIKLYNQEN 456
Cdd:pfam15905  286 lLESEKEELLREYEEKEQTL---NAELEELKEKLTLEEQEH 323
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
339-577 1.02e-03

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteriztic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 43.13  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  339 RRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ-QLKVQIAQLETALKS----------DLTDKTEIL 407
Cdd:pfam19220   41 RELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELeELVARLAKLEAALREaeaakeelriELRDKTAQA 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  408 DRLKTERGALINQNEKLVQENREL--QLQYLEQK-----QQLDELKKRIKLYNQENDInADELSEALLLIKAQKEQKNGD 480
Cdd:pfam19220  121 EALERQLAAETEQNRALEEENKALreEAQAAEKAlqraeGELATARERLALLEQENRR-LQALSEEQAAELAELTRRLAE 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  481 LSFLVKVDSEINKDLERSMRELQATH--AETVQELEKTRnmliMQHKINKdYQMEVEAVTRKMENLQQdyeLKVEQYVHL 558
Cdd:pfam19220  200 LETQLDATRARLRALEGQLAAEQAERerAEAQLEEAVEA----HRAERAS-LRMKLEALTARAAATEQ---LLAEARNQL 271
                          250
                   ....*....|....*....
gi 1034594131  559 LDiRAARIHKLEAQLKDIA 577
Cdd:pfam19220  272 RD-RDEAIRAAERRLKEAS 289
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
202-466 1.05e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 42.96  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  202 EEARGEIRNLENVIQSQRGQIEELEhlaeilkTQLRRKENEIELSLLQLREQQATDQRSNIR---DNVEMIKLHKQLVEK 278
Cdd:pfam07888  125 AAHEARIRELEEDIKTLTQRVLERE-------TELERMKERAKKAGAQRKEEEAERKQLQAKlqqTEEELRSLSKEFQEL 197
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRlkccSLEKQLHSmkfSERRIEELQDRINDLEKERell 358
Cdd:pfam07888  198 RNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELR----SLQERLNA---SERKVEGLGEELSSMAAQR--- 267
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  359 kenydklyDSAFSAAHeeQWKLKEQQLKVQIAQLETALKSDLTdkteildRLKTERGALIN----QNEKLVQENRELQ-L 433
Cdd:pfam07888  268 --------DRTQAELH--QARLQAAQLTLQLADASLALREGRA-------RWAQERETLQQsaeaDKDRIEKLSAELQrL 330
                          250       260       270
                   ....*....|....*....|....*....|...
gi 1034594131  434 QYLEQKQQLDELKKRIKLyNQENDINADELSEA 466
Cdd:pfam07888  331 EERLQEERMEREKLEVEL-GREKDCNRVQLSES 362
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
207-410 1.08e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 42.22  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIElsllqlreqqatdqrsnirdnvemiKLHKQLVEKSNALSAME 286
Cdd:COG1579     18 ELDRLEHRLKELPAELAELEDELAALEARLEAAKTELE-------------------------DLEKEIKRLELEIEEVE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  287 GKFIQLQEKQRTLRishdalmaNGDELNmqlkeqrlkccSLEKQLHSMKfseRRIEELQDRINDLEKERELLKENYDKLy 366
Cdd:COG1579     73 ARIKKYEEQLGNVR--------NNKEYE-----------ALQKEIESLK---RRISDLEDEILELMERIEELEEELAEL- 129
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1034594131  367 dSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRL 410
Cdd:COG1579    130 -EAELAELEAELEEKKAELDEELAELEAELEELEAEREELAAKI 172
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
201-555 1.14e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 42.97  E-value: 1.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQAtdqrsnirdnvEMIKLHKQLVEKSN 280
Cdd:COG4372     40 LDKLQEELEQLREELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQA-----------ELAQAQEELESLQE 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 ALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQrlkccslekqlhsmkfsERRIEELQDRINDLEKERELLKE 360
Cdd:COG4372    109 EAEELQEELEELQKERQDLEQQRKQLEAQIAELQSEIAER-----------------EEELKELEEQLESLQEELAALEQ 171
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  361 NYDKL----YDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYL 436
Cdd:COG4372    172 ELQALseaeAEQALDELLKEANRNAEKEEELAEAEKLIESLPRELAEELLEAKDSLEAKLGLALSALLDALELEEDKEEL 251
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  437 EQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKT 516
Cdd:COG4372    252 LEEVILKEIEELELAILVEKDTEEEELEIAALELEALEEAALELKLLALLLNLAALSLIGALEDALLAALLELAKKLELA 331
                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1034594131  517 RNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 555
Cdd:COG4372    332 LAILLAELADLLQLLLVGLLDNDVLELLSKGAEAGVADG 370
PTZ00121 PTZ00121
MAEBL; Provisional
65-624 1.19e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   65 KQHARKQEDKIKRMATKLirlVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKqqlqtqg 144
Cdd:PTZ00121  1349 KAEAEAAADEAEAAEEKA---EAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKK------- 1418
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  145 yrqtpynnvqsRINTGRRKANENAGLQECPRKGIKFQDADVAETPhpmftkygnslLEEARgEIRNLENVIQSQRgQIEE 224
Cdd:PTZ00121  1419 -----------KADEAKKKAEEKKKADEAKKKAEEAKKADEAKKK-----------AEEAK-KAEEAKKKAEEAK-KADE 1474
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  225 LEHLAEilktqLRRKENEielslLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHD 304
Cdd:PTZ00121  1475 AKKKAE-----EAKKADE-----AKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEE 1544
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  305 ALMAngDELNmqlKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQ 384
Cdd:PTZ00121  1545 KKKA--DELK---KAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  385 LKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRiklynqendiNADELS 464
Cdd:PTZ00121  1620 IKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKA----------EEDEKK 1689
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  465 EALLLIKAQKEQKNGDlsflvkvdsEINKDLERSMRElqathAETVQELEKTRNMLIMQHKinkdyqMEVEAVTRKMENL 544
Cdd:PTZ00121  1690 AAEALKKEAEEAKKAE---------ELKKKEAEEKKK-----AEELKKAEEENKIKAEEAK------KEAEEDKKKAEEA 1749
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  545 QQDYEL--KVEQYVHLLDIRAARIHKLEAQLkdIAYGTKQYKFKPEIMPDDSV-DEFDETIHLERGENLFEIHIN--KVT 619
Cdd:PTZ00121  1750 KKDEEEkkKIAHLKKEEEKKAEEIRKEKEAV--IEEELDEEDEKRRMEVDKKIkDIFDNFANIIEGGKEGNLVINdsKEM 1827

                   ....*
gi 1034594131  620 FSSEV 624
Cdd:PTZ00121  1828 EDSAI 1832
ClpA COG0542
ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein ...
341-458 1.85e-03

ATP-dependent Clp protease, ATP-binding subunit ClpA [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440308 [Multi-domain]  Cd Length: 836  Bit Score: 42.76  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  341 IEELQDRINDLEKERELLKENYDKLydsafSAAHEEQWKLKEQQLKVQIAQLETALKSDltdkTEILDRLKTERGALINQ 420
Cdd:COG0542    413 LDELERRLEQLEIEKEALKKEQDEA-----SFERLAELRDELAELEEELEALKARWEAE----KELIEEIQELKEELEQR 483
                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034594131  421 NEKLVQENRELQlqylEQKQQLDELKKRIKLYNQENDI 458
Cdd:COG0542    484 YGKIPELEKELA----ELEEELAELAPLLREEVTEEDI 517
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
83-360 1.90e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.42  E-value: 1.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   83 IRLVNDKKRYERVgggpKRLGRDVEMEEM--IEQLQekvHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNvQSRINTG 160
Cdd:pfam17380  353 IRQEERKRELERI----RQEEIAMEISRMreLERLQ---MERQQKNERVRQELEAARKVKILEEERQRKIQQ-QKVEMEQ 424
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  161 RRKANENAGLQECPRkgikfqdadvaetphpmftkygnslLEEARGeiRNLENViqsqRGQIEELEHLAEILKTQ-LRRK 239
Cdd:pfam17380  425 IRAEQEEARQREVRR-------------------------LEEERA--REMERV----RLEEQERQQQVERLRQQeEERK 473
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  240 ENEIELSLLQLREQQATDQRSNIRDNvEMIKLHKQLVEKSNALSAMEGkfiQLQEKQRTLRISHDALMANGDELNMQLKE 319
Cdd:pfam17380  474 RKKLELEKEKRDRKRAEEQRRKILEK-ELEERKQAMIEEERKRKLLEK---EMEERQKAIYEEERRREAEEERRKQQEME 549
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 1034594131  320 QRLKccsLEKQLhsMKFSERRieelqDRINDLEKERELLKE 360
Cdd:pfam17380  550 ERRR---IQEQM--RKATEER-----SRLEAMEREREMMRQ 580
PTZ00121 PTZ00121
MAEBL; Provisional
69-556 1.91e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 1.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   69 RKQEDKIKRMATKL---IRLVNDKKRYERvgggpkrlGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGY 145
Cdd:PTZ00121  1194 RKAEDARKAEAARKaeeERKAEEARKAED--------AKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHF 1265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  146 --RQTPYNNVQSRINTGRRKANENAGLQECpRKGIKFQDADVAETPHPMFTKygnslLEEARGEIRNLENVIQSQRGQIE 223
Cdd:PTZ00121  1266 arRQAAIKAEEARKADELKKAEEKKKADEA-KKAEEKKKADEAKKKAEEAKK-----ADEAKKKAEEAKKKADAAKKKAE 1339
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  224 ELEHLAEILKTQLRRKENEIELSllQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALsamEGKFIQLQEKQRTLRISH 303
Cdd:PTZ00121  1340 EAKKAAEAAKAEAEAAADEAEAA--EEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEA---KKKAEEDKKKADELKKAA 1414
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  304 DAlMANGDELNMQLKEQRlKCCSLEKQLHSmkfsERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ 383
Cdd:PTZ00121  1415 AA-KKKADEAKKKAEEKK-KADEAKKKAEE----AKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEA 1488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  384 QLKVQiaqlETALKSDLTDKTEildrlktERGALINQNEKLVQENRELQLQYLEQKQQLDELKKriklynQENDINADEL 463
Cdd:PTZ00121  1489 KKKAE----EAKKKADEAKKAA-------EAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKK------AEEKKKADEL 1551
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  464 SEALLLIKAQKEQKNgdlsflvkvdSEINKDLERsmRELQATHAETVQELEKTRNMLIMQhKINKDYQMEVEAVTRKMEN 543
Cdd:PTZ00121  1552 KKAEELKKAEEKKKA----------EEAKKAEED--KNMALRKAEEAKKAEEARIEEVMK-LYEEEKKMKAEEAKKAEEA 1618
                          490
                   ....*....|...
gi 1034594131  544 LQQDYELKVEQYV 556
Cdd:PTZ00121  1619 KIKAEELKKAEEE 1631
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
209-568 1.93e-03

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 460256 [Multi-domain]  Cd Length: 1081  Bit Score: 42.47  E-value: 1.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  209 RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQAtdqrsnirdnvemiklhkqlvEKSNALSamegk 288
Cdd:pfam01576  211 RKLEGESTDLQEQIAELQAQIAELRAQLAKKEEELQAALARLEEETA---------------------QKNNALK----- 264
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  289 fiqlqekqrtlriSHDALMANGDELNMQLKEQRLKCCSLEKQlhsmkfseRRieelqdrinDLEKERELLKENYDKLYDS 368
Cdd:pfam01576  265 -------------KIRELEAQISELQEDLESERAARNKAEKQ--------RR---------DLGEELEALKTELEDTLDT 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  369 afSAAHEEQWKLKEQQL--------------KVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQENRELQ-- 432
Cdd:pfam01576  315 --TAAQQELRSKREQEVtelkkaleeetrshEAQLQEMRQKHTQALEELTEQLEQAKRNKANLEKAKQALESENAELQae 392
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  433 LQYLEQKQQLDELKKRiKLYNQENDINA---------DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 503
Cdd:pfam01576  393 LRTLQQAKQDSEHKRK-KLEGQLQELQArlseserqrAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQ 471
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034594131  504 AThaetvQEL--EKTRNMLIMQHKINkdyQMEVEAvTRKMENLQQDYELK--VEQYVHLLDIRAARIHK 568
Cdd:pfam01576  472 DT-----QELlqEETRQKLNLSTRLR---QLEDER-NSLQEQLEEEEEAKrnVERQLSTLQAQLSDMKK 531
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
29-576 1.96e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 42.52  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   29 ETSTTRTMKSRQAVSRVSREEL---EDRFLRLHDEnilLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGggPKRLGRD 105
Cdd:pfam12128  271 ETLIASRQEERQETSAELNQLLrtlDDQWKEKRDE---LNGELSAADAAVAKDRSELEALEDQHGAFLDAD--IETAAAD 345
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  106 VEMEEMIEQlqekvhELEKQNETLKnrLISAKQQLQTQGY------RQTPYNNVQSRINTGRRKANENAGLQecprkgik 179
Cdd:pfam12128  346 QEQLPSWQS------ELENLEERLK--ALTGKHQDVTAKYnrrrskIKEQNNRDIAGIKDKLAKIREARDRQ-------- 409
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  180 fqdadvaetphpmftkygnslLEEARGEIRNLENVIQSQRGQieeleHLAEILKTQLRRKENEIELSLLQLREQQATDQR 259
Cdd:pfam12128  410 ---------------------LAVAEDDLQALESELREQLEA-----GKLEFNEEEYRLKSRLGELKLRLNQATATPELL 463
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  260 SNIRDNVEMIKLHKQLVEKSNAlsamegKFIQLQEKQRTLRISHD-ALMANGDElNMQLKEQRLKCCSLEKQL----HSM 334
Cdd:pfam12128  464 LQLENFDERIERAREEQEAANA------EVERLQSELRQARKRRDqASEALRQA-SRRLEERQSALDELELQLfpqaGTL 536
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  335 kfserrieelqdrINDLEKERELLKENYDKLYDSAF-------------SAAHEE---------------QWKLKEQQLK 386
Cdd:pfam12128  537 -------------LHFLRKEAPDWEQSIGKVISPELlhrtdldpevwdgSVGGELnlygvkldlkridvpEWAASEEELR 603
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  387 VQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKL------VQENRELQLQYLEQKQQL-----DELKKRIKLYNQE 455
Cdd:pfam12128  604 ERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREEtfartaLKNARLDLRRLFDEKQSEkdkknKALAERKDSANER 683
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  456 NDINADELSEALLLIKAQKEQKNGDLsflvkvdseinkdlersmRELQATHAETVQELEKTRNMLIMQHKINKDyqMEVE 535
Cdd:pfam12128  684 LNSLEAQLKQLDKKHQAWLEEQKEQK------------------REARTEKQAYWQVVEGALDAQLALLKAAIA--ARRS 743
                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 1034594131  536 AVTRKMENLQQDYELKVEQyvhlLDIRAARIHKLEAQLKDI 576
Cdd:pfam12128  744 GAKAELKALETWYKRDLAS----LGVDPDVIAKLKREIRTL 780
DUF4686 pfam15742
Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins ...
208-456 2.02e-03

Domain of unknown function (DUF4686); This family of proteins is found in eukaryotes. Proteins in this family are typically between 498 and 775 amino acids in length. There is a conserved DLK sequence motif.


Pssm-ID: 464838 [Multi-domain]  Cd Length: 384  Bit Score: 41.97  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  208 IRNLENVIQSQRGQIEELEHLAEILkTQLRRKENEIELSLLQLreQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
Cdd:pfam15742   92 IRELELEVLKQAQSIKSQNSLQEKL-AQEKSRVADAEEKILEL--QQKLEHAHKVCLTDTCILEKKQLEERIKEASENEA 168
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  288 KF-IQLQEKQRTLRIshdaLMANGDELNMQLKEQRLKCCSLE----KQLHSMKFSERRIEELQDRIND------------ 350
Cdd:pfam15742  169 KLkQQYQEEQQKRKL----LDQNVNELQQQVRSLQDKEAQLEmtnsQQQLRIQQQEAQLKQLENEKRKsdehlksnqels 244
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  351 -----LEKERELLKENYDKLYDSAfsAAHEEQWKLKEQQLKVQIAQL------ETALKS----DLTDKTEILDRL----K 411
Cdd:pfam15742  245 eklssLQQEKEALQEELQQVLKQL--DVHVRKYNEKHHHHKAKLRRAkdrlvhEVEQRDerikQLENEIGILQQQsekeK 322
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1034594131  412 TERGALINQNEKLVQENRELQLQYLEQ-------KQQLDELKKRIKLYNQEN 456
Cdd:pfam15742  323 AFQKQVTAQNEILLLEKRKLLEQLTEQeeliknnKRTISSVQNRVNFLDEEN 374
mukB PRK04863
chromosome partition protein MukB;
264-556 2.56e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 42.25  E-value: 2.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  264 DNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE---QRLKccSLEKQLHSMKFSERR 340
Cdd:PRK04863   835 PEAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRLLPRLNLLADEtlaDRVE--EIREQLDEAEEAKRF 912
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  341 IEELQDRINDLEKERELLK---ENYDKLYDSAFSAahEEQWKLKEQQLK--VQIAQLETALK-----SDLTDKTEILDRL 410
Cdd:PRK04863   913 VQQHGNALAQLEPIVSVLQsdpEQFEQLKQDYQQA--QQTQRDAKQQAFalTEVVQRRAHFSyedaaEMLAKNSDLNEKL 990
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  411 KTERGALINQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEalllikaqkeqkngdlsFLVKVDSE 490
Cdd:PRK04863   991 RQRLEQAEQERTRAREQLRQAQAQLAQYNQVLASLKSSYDAKRQMLQELKQELQD-----------------LGVPADSG 1053
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034594131  491 INKDLERSMRELQA---THAETVQELEKTRNMLimqhkinkdyQMEVEAVTRKMENLQQDYELKVEQYV 556
Cdd:PRK04863  1054 AEERARARRDELHArlsANRSRRNQLEKQLTFC----------EAEMDNLTKKLRKLERDYHEMREQVV 1112
46 PHA02562
endonuclease subunit; Provisional
232-515 2.68e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.92  E-value: 2.68e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  232 LKTQLRRK--ENEIELSLL---------QLRE--QQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEgkfiqLQEKQRT 298
Cdd:PHA02562   147 LSAPARRKlvEDLLDISVLsemdklnkdKIRElnQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGEN-----IARKQNK 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  299 LrishdalmangDELnmqLKEqrlkccslEKQLHSmkfserRIEELQDRINDLEKERELLKENYDKLYDSAFSAaheeqw 378
Cdd:PHA02562   222 Y-----------DEL---VEE--------AKTIKA------EIEELTDELLNLVMDIEDPSAALNKLNTAAAKI------ 267
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  379 KLKEQQLKVQIAQLET-----ALKSDLTDKTEILdrlktergalinqnEKLVQENRELQLQYLEQKQQLDELKKRIKLYN 453
Cdd:PHA02562   268 KSKIEQFQKVIKMYEKggvcpTCTQQISEGPDRI--------------TKIKDKLKELQHSLEKLDTAIDELEEIMDEFN 333
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034594131  454 qendinadELSEALLLIKAQKEQKNGDLSFLVKVdseiNKDLERSMRELQATHAETVQELEK 515
Cdd:PHA02562   334 --------EQSKKLLELKNKISTNKQSLITLVDK----AKKVKAAIEELQAEFVDNAEELAK 383
CEP63 pfam17045
Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole ...
248-450 4.16e-03

Centrosomal protein of 63 kDa; CEP63 is a family of eukaryotic proteins involved in centriole activity.


Pssm-ID: 465338 [Multi-domain]  Cd Length: 264  Bit Score: 40.57  E-value: 4.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  248 LQLREQQATDQRSNI-RDNVEMIKLHKQLVEKSNALSAM----EGKFIQLQEKQRTLRISHDALMANgdelnmQLKEQRL 322
Cdd:pfam17045   37 LDIREEELLSARNTLeRKHKEIGLLRQQLEELEKGKQELvakyEQQLQKLQEELSKLKRSYEKLQRK------QLKEARE 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  323 KCCSLEKQLHSMKFSERRIEEL--------------QDRINDLEKERELLKENYDKLYDSAFSA--AHEEQwKLKEQQLK 386
Cdd:pfam17045  111 EAKSREEDRSELSRLNGKLEEFrqksleweqqrlqyQQQVASLEAQRKALAEQSSLIQSAAYQVqlEGRKQ-CLEASQSE 189
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034594131  387 VQ--IAQLETALKSDLTDKTEIlDRLKTERGALINQNEKLVQENRELQLQ---YLEQKQQLDELKKRIK 450
Cdd:pfam17045  190 IQrlRSKLERAQDSLCAQELEL-ERLRMRVSELGDSNRKLLEEQQRLLEElrmSQRQLQVLQNELMELK 257
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
201-517 4.58e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 41.36  E-value: 4.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKEneielsllqlREQQATDQRSNiRDNVEMIKLHKQLVEKSN 280
Cdd:pfam12128  236 IMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIA----------SRQEERQETSA-ELNQLLRTLDDQWKEKRD 304
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  281 A----LSAMEGKfiqLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMkfsERRIEELQDRINDLEKERE 356
Cdd:pfam12128  305 ElngeLSAADAA---VAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENL---EERLKALTGKHQDVTAKYN 378
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  357 LLKENYDklydsafsaaheeqwklkeQQLKVQIAQLEtalkSDLTDKTEILDRLKT-ERGALINQ----NEKLVQENREL 431
Cdd:pfam12128  379 RRRSKIK-------------------EQNNRDIAGIK----DKLAKIREARDRQLAvAEDDLQALeselREQLEAGKLEF 435
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  432 QLQYLEQKQQLDELKKRiklynqendINADELSEALLLikaQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQ 511
Cdd:pfam12128  436 NEEEYRLKSRLGELKLR---------LNQATATPELLL---QLENFDERIERAREEQEAANAEVERLQSELRQARKRRDQ 503

                   ....*.
gi 1034594131  512 ELEKTR 517
Cdd:pfam12128  504 ASEALR 509
PRK11281 PRK11281
mechanosensitive channel MscK;
112-470 4.95e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 41.44  E-value: 4.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  112 IEQLQEKVHELEKQNETLKNRLISAKQQL---QTQGYR-QTPYNNVQSRINTGRRKANENAGLQECPRKGIKF-----QD 182
Cdd:PRK11281   123 LRQLESRLAQTLDQLQNAQNDLAEYNSQLvslQTQPERaQAALYANSQRLQQIRNLLKGGKVGGKALRPSQRVllqaeQA 202
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  183 ADVAETPHPMFTKYGNSLLEEARGEIRNLENViqsqrgQIEELEHLAEILKTQLRRKEneielslLQLREQQAtdqrsni 262
Cdd:PRK11281   203 LLNAQNDLQRKSLEGNTQLQDLLQKQRDYLTA------RIQRLEHQLQLLQEAINSKR-------LTLSEKTV------- 262
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  263 rdnvemiklhKQLVEKSNALSAMEGKFIQlQEKQRTLRIShDALMANGDELNmQLKEQRLKccsLEKQLHSMKFSERRIE 342
Cdd:PRK11281   263 ----------QEAQSQDEAARIQANPLVA-QELEINLQLS-QRLLKATEKLN-TLTQQNLR---VKNWLDRLTQSERNIK 326
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  343 E------------------------------LQDRINDLEKERELLKENYDKLYDSAFSAAheeqwKLKEQQLKVQIAQL 392
Cdd:PRK11281   327 EqisvlkgslllsrilyqqqqalpsadliegLADRIADLRLEQFEINQQRDALFQPDAYID-----KLEAGHKSEVTDEV 401
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  393 ETALKSDLTDKTEILDRLKTERGALINQ------------------NEKLVQE------NRELQLQYLEQ-----KQQLD 443
Cdd:PRK11281   402 RDALLQLLDERRELLDQLNKQLNNQLNLainlqlnqqqllsvsdslQSTLTQQifwvnsNKPMDLDWLKAfpqalKDQFK 481
                          410       420
                   ....*....|....*....|....*..
gi 1034594131  444 ELKKRIKLYNqendiNADELSEALLLI 470
Cdd:PRK11281   482 SLKITVSFSN-----LWDGLFIALLLF 503
YtrI COG5926
Uncharacterized sporulation protein YtrI [Cell cycle control, cell division, chromosome ...
339-439 5.32e-03

Uncharacterized sporulation protein YtrI [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 444627 [Multi-domain]  Cd Length: 167  Bit Score: 39.16  E-value: 5.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  339 RRIEELQDRINDLEKERELLKENYDKLYDsafsaahEEQWKLKEQQLKVQIAQLETaLKSDLTDKTEILDRLKTERGALI 418
Cdd:COG5926     43 EENRELQEEIAELENKIEILLEDQEELNE-------ENKEKLTVQSIEIKITNAES-YKLDNLTLHELEELIKEELSHLI 114
                           90       100
                   ....*....|....*....|.
gi 1034594131  419 NQNEKLVQENRELQLQYLEQK 439
Cdd:COG5926    115 GKDIETVAKSRDLLISTIENK 135
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
198-573 5.56e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 461677 [Multi-domain]  Cd Length: 660  Bit Score: 40.88  E-value: 5.56e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  198 NSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRdNVEMIKLHKQLVE 277
Cdd:pfam05557   89 NKKLNEKESQLADAREVISCLKNELSELRRQIQRAELELQSTNSELEELQERLDLLKAKASEAEQL-RQNLEKQQSSLAE 167
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  278 KSNALSAMEGKfIQLQE---------KQRTLRISH-DALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
Cdd:pfam05557  168 AEQRIKELEFE-IQSQEqdseivknsKSELARIPElEKELERLREHNKHLNENIENKLLLKEEVEDLKRKLEREEKYREE 246
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERGALINQNEKLVQE 427
Cdd:pfam05557  247 AATLELEKEKLEQELQSWVKLAQDTGLNLRSPEDLSRRIEQLQQREIVLKEENSSLTSSARQLEKARRELEQELAQYLKK 326
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  428 NRELQLQYLEQKQQLDELKKRIKLYNQE------------NDINADELSEALLLIKAQKEQ-------KNGDLSFLVKVD 488
Cdd:pfam05557  327 IEDLNKKLKRHKALVRRLQRRVLLLTKErdgyrailesydKELTMSNYSPQLLERIEEAEDmtqkmqaHNEEMEAQLSVA 406
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  489 SE-------INKDLERSMREL--QATHA------ETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKmENLQQDYELKVE 553
Cdd:pfam05557  407 EEelggykqQAQTLERELQALrqQESLAdpsyskEEVDSLRRKLETLELERQRLREQKNELEMELER-RCLQGDYDPKKT 485
                          410       420
                   ....*....|....*....|....*...
gi 1034594131  554 QYVHLLD--------IRAARIHKLEAQL 573
Cdd:pfam05557  486 KVLHLSMnpaaeayqQRKNQLEKLQAEI 513
mukB PRK04863
chromosome partition protein MukB;
199-354 6.01e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 6.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  199 SLLEEARGEIRNLENVIQ---------SQRGQIEELEhLAEILKTQLRRKENEIELSLLQLREQQAtdqrsnirdnvEMI 269
Cdd:PRK04863   949 QTQRDAKQQAFALTEVVQrrahfsyedAAEMLAKNSD-LNEKLRQRLEQAEQERTRAREQLRQAQA-----------QLA 1016
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  270 KLHKQLvekSNALSAMEGKFIQLQEKQR-----TLRISHDA---LMANGDELNMQLKEQRLKCCSLEKQLhsmKFSERRI 341
Cdd:PRK04863  1017 QYNQVL---ASLKSSYDAKRQMLQELKQelqdlGVPADSGAeerARARRDELHARLSANRSRRNQLEKQL---TFCEAEM 1090
                          170
                   ....*....|...
gi 1034594131  342 EELQDRINDLEKE 354
Cdd:PRK04863  1091 DNLTKKLRKLERD 1103
PRK12704 PRK12704
phosphodiesterase; Provisional
221-428 6.79e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.53  E-value: 6.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  221 QIEELEHLAEILKTQLRRKENEIElsllQLREQQATDQRSNIRDnvemiKLHKQLVEKSNALSAMEGKFIQlqekqrtlr 300
Cdd:PRK12704    32 KIKEAEEEAKRILEEAKKEAEAIK----KEALLEAKEEIHKLRN-----EFEKELRERRNELQKLEKRLLQ--------- 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  301 ishdalmangdelnmqlKEQRLkccslEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLydsafsaaHEEQwkl 380
Cdd:PRK12704    94 -----------------KEENL-----DRKLELLEKREEELEKKEKELEQKQQELEKKEEELEEL--------IEEQ--- 140
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1034594131  381 kEQQLKvQIAQL--ETAlKSDLTDKTEilDRLKTERGALINQNEKLVQEN 428
Cdd:PRK12704   141 -LQELE-RISGLtaEEA-KEILLEKVE--EEARHEAAVLIKEIEEEAKEE 185
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
112-466 7.14e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 40.67  E-value: 7.14e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  112 IEQLQEKVHELEKQNETLKNRLISAKQQLQTQgyrqtpynnvqsrintgRRKANENAGLQEcprkgIKFQDADVAetphp 191
Cdd:COG4913    612 LAALEAELAELEEELAEAEERLEALEAELDAL-----------------QERREALQRLAE-----YSWDEIDVA----- 664
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  192 mftkygnslleEARGEIRNLENVIQSQR---GQIEELEHLAEILKTQLRRKENEI-----ELSLLQLREQQATDQRSNIR 263
Cdd:COG4913    665 -----------SAEREIAELEAELERLDassDDLAALEEQLEELEAELEELEEELdelkgEIGRLEKELEQAEEELDELQ 733
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  264 DNVEMIKLHKQLVEKSNAlsamEGKFIQLQEKQRTLRIShDALMANGDELNMQLKEQRLKccsLEKQLHsmKFSERRIEE 343
Cdd:COG4913    734 DRLEAAEDLARLELRALL----EERFAAALGDAVERELR-ENLEERIDALRARLNRAEEE---LERAMR--AFNREWPAE 803
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  344 LQDRINDLEKERELLKEnYDKLYDSAFsAAHEEQWK-LKEQQLKVQIAQLETALKSDLTDKTEILDRLktergalinqNE 422
Cdd:COG4913    804 TADLDADLESLPEYLAL-LDRLEEDGL-PEYEERFKeLLNENSIEFVADLLSKLRRAIREIKERIDPL----------ND 871
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1034594131  423 KLVQ----ENRELQLQYLE-QKQQLDELKKRIKLYNQENDINADELSEA 466
Cdd:COG4913    872 SLKRipfgPGRYLRLEARPrPDPEVREFRQELRAVTSGASLFDEELSEA 920
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
47-370 7.44e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 7.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131   47 REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV-EMEEMIEQLQEKVHELEKQ 125
Cdd:TIGR02168  760 EAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAaNLRERLESLERRIAATERR 839
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  126 NETLKNRLISAKQQLQtqgyrqtpynNVQSRINTGRRKANEnagLQEcprkgiKFQDADVAETPHPMFTKYGNSLLEEAR 205
Cdd:TIGR02168  840 LEDLEEQIEELSEDIE----------SLAAEIEELEELIEE---LES------ELEALLNERASLEEALALLRSELEELS 900
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  206 GEIRNLENVIQSQRGQIEELEHLAEilktQLRRKENEIELSLLQLREQQATDQrsniRDNVEMIKLHKQLVEKSnaLSAM 285
Cdd:TIGR02168  901 EELRELESKRSELRRELEELREKLA----QLELRLEGLEVRIDNLQERLSEEY----SLTLEEAEALENKIEDD--EEEA 970
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034594131  286 EGKFIQLQEKQRTL-RISHDALmangDELnmQLKEQRLKccSLEKQLHSMKFSERRIEELQDRINDLEKER-----ELLK 359
Cdd:TIGR02168  971 RRRLKRLENKIKELgPVNLAAI----EEY--EELKERYD--FLTAQKEDLTEAKETLEEAIEEIDREARERfkdtfDQVN 1042
                          330
                   ....*....|.
gi 1034594131  360 ENYDKLYDSAF 370
Cdd:TIGR02168 1043 ENFQRVFPKLF 1053
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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