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Conserved domains on  [gi|1034649026|ref|XP_016865930|]
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lysine-specific histone demethylase 2 isoform X2 [Homo sapiens]

Protein Classification

lysine-specific histone demethylase 1B( domain architecture ID 13726372)

lysine-specific histone demethylase 1B (KDM1B) demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor

EC:  1.14.99.66
Gene Symbol:  KDM1B
Gene Ontology:  GO:0008270|GO:0050660|GO:0032452|GO:0042393
PubMed:  23266887|23260659

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02328 super family cl33466
lysine-specific histone demethylase 1 homolog
 311-828 3.74e-97

lysine-specific histone demethylase 1 homolog


The actual alignment was detected with superfamily member PLN02328:

Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 311 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 389
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 390 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 465
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 466 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 542
Cdd:PLN02328  316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 543 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 622
Cdd:PLN02328  392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 623 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 702
Cdd:PLN02328  471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 703 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 780
Cdd:PLN02328  547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1034649026 781 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:PLN02328  627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-200 3.67e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


:

Pssm-ID: 462181  Cd Length: 46  Bit Score: 50.00  E-value: 3.67e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034649026 138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKRrgfavlprpetsdhCSLPEDL 200
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYNS--------------CDAPEEI 46
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 311-828 3.74e-97

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 311 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 389
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 390 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 465
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 466 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 542
Cdd:PLN02328  316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 543 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 622
Cdd:PLN02328  392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 623 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 702
Cdd:PLN02328  471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 703 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 780
Cdd:PLN02328  547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1034649026 781 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:PLN02328  627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 408-828 3.00e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 254.72  E-value: 3.00e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 408 RQLHNFGIKVTVLEAKDRIGGRVWDDKsFKGVTVGRGAQIVNGCiNNPVALMCEQLGI----SMHKFGERCDLIQEGGRI 483
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 484 tDPTIDKRMDFHFNALLDVVSEWR-KDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQ-----------VLQFHLSN 551
Cdd:pfam01593  86 -YPGDFRRVPAGWEGLLEFGRLLSiPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpgdvevwdrlIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 552 LEYACGSNLHQVSARS----WDHNEFFAQFAGDHTLLTPGYSVIIEKLAE---GLDIQLKSPVQCIDYSGDEVQVTTTDG 624
Cdd:pfam01593 165 LPFASGAFAGDPSELSaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 625 TGYSAQKVLVTVPLALLQkgAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDsKVQGADFFGHVPPSASKRGLFA 704
Cdd:pfam01593 245 EVIEADAVIVTVPLGVLK--RILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP-DLGLLGLLSELLTGLGTAFSWL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 705 VFYDMDPQKKHSVLMS-VIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGG 783
Cdd:pfam01593 322 TFPNRAPPGKGLLLLVyVGPGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQYGP 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1034649026 784 SGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:pfam01593 401 GHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
408-830 9.43e-75

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 250.61  E-value: 9.43e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 408 RQLHNFGIKVTVLEAKDRIGGRVW-DDKSFKGVTVGRGAQIVNGcinNPVALM--CEQLGISMHKFGERCD---LIQEGG 481
Cdd:COG1231    24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFPNENGnalLYLGGK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 482 RITDPTIDKRMDFHF-------NALLDVVSEWRKDKTQLQDVPLGEkieeiykaFIKESGIQFSelegqVLQFHLSNLEY 554
Cdd:COG1231   101 RVRAGEIAADLRGVAellakllRALAAALDPWAHPAAELDRESLAE--------WLRRNGASPS-----ARRLLGLLGAG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 555 ACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGL--DIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKV 632
Cdd:COG1231   168 EYGADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 633 LVTVPLALLQKgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSKRGLFAVFYDMD 710
Cdd:COG1231   248 IVTVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 711 PQ-KKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 789
Cdd:COG1231   318 GPdGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1034649026 790 IIAEdIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 830
Cdd:COG1231   397 ALAE-PDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-200 3.67e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 50.00  E-value: 3.67e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034649026 138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKRrgfavlprpetsdhCSLPEDL 200
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYNS--------------CDAPEEI 46
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 414-785 3.10e-04

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 44.06  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 414 GIKVTVLEAKDRIGGRVWDDKSfKGVTVGRGAQIVNGcINNPVALMCEQLGIS----MHKFGERCDLIQEGGRITDPT-I 488
Cdd:TIGR00562  29 PVELTLVEASDRVGGKIQTVKE-DGYLIERGPDSFLE-RKKSAPDLVKDLGLEhvlvSDATGQRYVLVNRGKLMPVPTkI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 489 DKRMDFHFNAL---LDVVSEWRKDKTQLQDVPLG---------EKIEEIYKAFIkeSGIQFSELEGQVL-----QFHLSN 551
Cdd:TIGR00562 107 APFVKTGLFSLggkLRAGMDFIRPASPGKDESVEefvrrrfgdEVVENLIEPLL--SGIYAGDPSKLSLkstfpKFYQTE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 552 LEYacGS---------NLHQvSARSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGLDIQLK-------SPVQCIDYSGD 615
Cdd:TIGR00562 185 QKH--GSlilgmkktrNLPQ-GSGLQLTAKKQGQDFQ-------TLATGLETLPEEIEKRLKltkvykgTKVTKLSHRGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 616 EVQVTTTDGTGYSAQKVLVTVPlallQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGadfFGHVPP 695
Cdd:TIGR00562 255 NYTLELDNGVTVETDSVVVTAP----HKAAAGLLSELSNSASSHLDKIHSPPVANVNLGFPEGSVDGELEG---FGFLIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 696 SASKRGLFAVFYD------MDPQKKhSVLMSVIAGEAVASVRTLDDKQVLQqcmATLRELFKEQEVP-DPTKYFVTRWST 768
Cdd:TIGR00562 328 RSSKFAILGCIFTsklfpnRAPPGK-TLLTAYIGGATDESIVDLSENEIIN---IVLRDLKKVLNINnEPEMLCVTRWHR 403

                         410       420
                  ....*....|....*....|....*.
gi 1034649026 769 ---------DPWIQMAYSFVKTGGSG 785
Cdd:TIGR00562 404 aipqyhvghDQRLKEARELLESAYPG 429
 
Name Accession Description Interval E-value
PLN02328 PLN02328
lysine-specific histone demethylase 1 homolog
 311-828 3.74e-97

lysine-specific histone demethylase 1 homolog


Pssm-ID: 215187 [Multi-domain]  Cd Length: 808  Bit Score: 321.17  E-value: 3.74e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 311 RDPTMYLALRNLILALWYTNCKEALTPQKCIPHIivrglvRIRCVQEVERILYFMTRKGLINTGV-LSVGADQYLLPKDY 389
Cdd:PLN02328  163 TEQANYIVVRNHILARWRSNVSNWLTRDHALESI------RAEHKNLVDSAYNFLLEHGYINFGVaPVIKEAQLRSFEGV 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 390 HNKSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVwDDKSFKGVTV----GRGAQIVNGCINNPVALMCEQLGI 465
Cdd:PLN02328  237 EPANVVVVGAGLAGLVAARQLLSMGFKVVVLEGRARPGGRV-KTMKMKGDGVvaaaDLGGSVLTGINGNPLGVLARQLGL 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 466 SMHKFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRK---DKTQLQDVPLGEKIEeiykAFIKESGIQFSELEG 542
Cdd:PLN02328  316 PLHKVRDICPLYLPDGKAVDAEIDSKIEASFNKLLDRVCKLRQamiEEVKSVDVNLGTALE----AFRHVYKVAEDPQER 391

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 543 QVLQFHLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTT 622
Cdd:PLN02328  392 MLLNWHLANLEYANASLMSNLSMAYWDQDDPY-EMGGDHCFIPGGNDTFVRELAKDLPIFYERTVESIRYGVDGVIVYAG 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 623 dGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGL 702
Cdd:PLN02328  471 -GQEFHGDMVLCTVPLGVLKKGSIEFYPELPQRKKDAIQRLGYGLLNKVALLFPYNFWGGEI---DTFGHLTEDPSMRGE 546

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 703 FAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVK 780
Cdd:PLN02328  547 FFLFYSYSSVSGGPLLIALVAGDAAVKFETLSPVESVKRVLQILRGIFhpKGIVVPDPVQAVCTRWGKDCFTYGSYSYVA 626

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*....
gi 1034649026 781 TGGSGEAYDIIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:PLN02328  627 VGSSGDDYDILAESVgDGRVFFAGEATNKQYPATMHGAFLSGMREAANI 675
PLN03000 PLN03000
amine oxidase
 316-829 2.31e-96

amine oxidase


Pssm-ID: 178578 [Multi-domain]  Cd Length: 881  Bit Score: 320.81  E-value: 2.31e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 316 YLALRNLILALWYTNCKEALTPQKCIphiivrGLVRIRCVQEVERILYFMTRKGLINTGVLSVGADQYllPKDYHNKSVI 395
Cdd:PLN03000  117 YILIRNHIISKWRENISSWVTKEMFL------GSIPKHCSSLLDSAYNYLVTHGYINFGIAQAIKDKF--PAQSSKSSVV 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 396 IIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDK---SFKGVTVGRGAQIVNGCINNPVALMCEQLGISMHKFGE 472
Cdd:PLN03000  189 IVGAGLSGLAAARQLMRFGFKVTVLEGRKRPGGRVYTKKmeaNRVGAAADLGGSVLTGTLGNPLGIIARQLGSSLYKVRD 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 473 RCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQLQ-DVPLGEKIEeiykAFIKESGIQFSELEGQVLQFHLSN 551
Cdd:PLN03000  269 KCPLYRVDGKPVDPDVDLKVEVAFNQLLDKASKLRQLMGDVSmDVSLGAALE----TFRQVSGNDVATEEMGLFNWHLAN 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 552 LEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTgYSAQK 631
Cdd:PLN03000  345 LEYANAGLVSKLSLAFWDQDDPY-DMGGDHCFLPGGNGRLVQALAENVPILYEKTVQTIRYGSNGVKVIAGNQV-YEGDM 422

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 632 VLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFYDMDP 711
Cdd:PLN03000  423 VLCTVPLGVLKNGSIKFVPELPQRKLDCIKRLGFGLLNKVAMLFPYVFWSTDL---DTFGHLTEDPNYRGEFFLFYSYAP 499

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 712 QKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQ--EVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 789
Cdd:PLN03000  500 VAGGPLLIALVAGEAAHKFETMPPTDAVTRVLHILRGIYEPQgiNVPDPLQTVCTRWGGDPFSLGSYSNVAVGASGDDYD 579

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|.
gi 1034649026 790 IIAEDI-QGTVFFAGEATNRHFPQTVTGAYLSGVREASKIA 829
Cdd:PLN03000  580 ILAESVgDGRLFFAGEATTRRYPATMHGAFVTGLREAANMA 620
PLN02529 PLN02529
lysine-specific histone demethylase 1
 316-828 1.08e-95

lysine-specific histone demethylase 1


Pssm-ID: 178144 [Multi-domain]  Cd Length: 738  Bit Score: 315.29  E-value: 1.08e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 316 YLALRNLILALWYTNCKEALTpqkciphiivRGLVRIRCVQEVERILY----FMTRKGLINTGVLSVGADQylLPKDYHN 391
Cdd:PLN02529   93 YIVVRNHILARWRSNVGIWLS----------KGQIKETVSSEYEHLISaaydFLLYNGYINFGVSPSFASP--IPEEGTE 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 392 KSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDK-SFKG--VTVGRGAQIVNGCINNPVALMCEQLGISMH 468
Cdd:PLN02529  161 GSVIIVGAGLAGLAAARQLLSFGFKVVVLEGRNRPGGRVYTQKmGRKGqfAAVDLGGSVITGIHANPLGVLARQLSIPLH 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 469 KFGERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKTQL-QDVPLGEKIEEIYKAFikesGIQFSELEGQVLQF 547
Cdd:PLN02529  241 KVRDNCPLYKPDGALVDKEIDSNIEFIFNKLLDKVTELRQIMGGFaNDISLGSVLERLRQLY----GVARSTEERQLLDW 316

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 548 HLSNLEYACGSNLHQVSARSWDHNEFFaQFAGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQVTTTDGTgY 627
Cdd:PLN02529  317 HLANLEYANAGCLSDLSAAYWDQDDPY-EMGGDHCFLAGGNWRLINALCEGVPIFYGKTVDTIKYGNDGVEVIAGSQV-F 394

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 628 SAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFY 707
Cdd:PLN02529  395 QADMVLCTVPLGVLKKRTIRFEPELPRRKLAAIDRLGFGLLNKVAMVFPSVFWGEEL---DTFGCLNESSNKRGEFFLFY 471

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 708 DMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELF--KEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSG 785
Cdd:PLN02529  472 GYHTVSGGPALVALVAGEAAQRFENTDPSTLLHRVLSVLRGIYnpKGINVPDPIQTICTRWGSDPLSYGSYSHVRVQSSG 551

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|...
gi 1034649026 786 EAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:PLN02529  552 SDYDILAESVSGRLFFAGEATTRQYPATMHGAFLSGLREASRI 594
PLN02976 PLN02976
amine oxidase
 392-828 7.16e-83

amine oxidase


Pssm-ID: 215527 [Multi-domain]  Cd Length: 1713  Bit Score: 291.00  E-value: 7.16e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026  392 KSVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGC--------INNPVALMCEQL 463
Cdd:PLN02976   694 KKIIVVGAGPAGLTAARHLQRQGFSVTVLEARSRIGGRVYTDRSSLSVPVDLGASIITGVeadvaterRPDPSSLICAQL 773

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026  464 GISMHKFGERCDL--IQEGGRITDpTIDKRMDFHFNALLD----VVSE-----------------------------WRK 508
Cdd:PLN02976   774 GLELTVLNSDCPLydVVTGEKVPA-DLDEALEAEYNSLLDdmvlLVAQkgehamkmsledgleyalkrrrmprpgvdIDE 852

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026  509 DKTQLQDVPL--GEKIEEIYKAFIKESGIQF-SELEGQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAQFAGDHTLLT 585
Cdd:PLN02976   853 TELGNAADDLydSASTGVDGGHCEKESKEDVlSPLERRVMNWHFAHLEYGCAALLKEVSLPYWNQDDVYGGFGGAHCMIK 932

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026  586 PGYSVIIEKLAEGLDIQLKSPVQCIDYSGDE----------VQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEK 655
Cdd:PLN02976   933 GGYSNVVESLAEGLDIHLNHVVTDVSYGSKDagasgssrkkVKVSTSNGSEFLGDAVLITVPLGCLKAETIKFSPPLPDW 1012

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026  656 KMKAINSLGAGIIEKIALQFPYRFWDSKVqgaDFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDD 735
Cdd:PLN02976  1013 KYSSIQRLGFGVLNKVVLEFPEVFWDDSV---DYFGATAEETDLRGQCFMFWNVKKTVGAPVLIALVVGKAAIDGQSMSS 1089

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026  736 KQVLQQCMATLRELFKEQEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFAGEATNRHFPQTVT 815
Cdd:PLN02976  1090 SDHVNHALMVLRKLFGEALVPDPVASVVTDWGRDPFSYGAYSYVAIGASGEDYDILGRPVENCLFFAGEATCKEHPDTVG 1169

                          490
                   ....*....|...
gi 1034649026  816 GAYLSGVREASKI 828
Cdd:PLN02976  1170 GAMMSGLREAVRI 1182
Amino_oxidase pfam01593
Flavin containing amine oxidoreductase; This family consists of various amine oxidases, ...
 408-828 3.00e-76

Flavin containing amine oxidoreductase; This family consists of various amine oxidases, including maze polyamine oxidase (PAO)and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. The family also contains phytoene dehydrogenases and related enzymes. In vertebrates MAO plays an important role regulating the intracellular levels of amines via there oxidation; these include various neurotransmitters, neurotoxins and trace amines. In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammonium. PAOs in plants, bacteria and protozoa oxidase spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.


Pssm-ID: 396255 [Multi-domain]  Cd Length: 446  Bit Score: 254.72  E-value: 3.00e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 408 RQLHNFGIKVTVLEAKDRIGGRVWDDKsFKGVTVGRGAQIVNGCiNNPVALMCEQLGI----SMHKFGERCDLIQEGGRI 483
Cdd:pfam01593   8 RELLRAGHDVTVLEARDRVGGRIRTVR-DDGFLIELGAMWFHGA-QPPLLALLKELGLedrlVLPDPAPFYTVLFAGGRR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 484 tDPTIDKRMDFHFNALLDVVSEWR-KDKTQLQDVPLGEKIEEIYKAFIKESGIQFSELEGQ-----------VLQFHLSN 551
Cdd:pfam01593  86 -YPGDFRRVPAGWEGLLEFGRLLSiPEKLRLGLAALASDALDEFDLDDFSLAESLLFLGRRgpgdvevwdrlIDPELFAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 552 LEYACGSNLHQVSARS----WDHNEFFAQFAGDHTLLTPGYSVIIEKLAE---GLDIQLKSPVQCIDYSGDEVQVTTTDG 624
Cdd:pfam01593 165 LPFASGAFAGDPSELSaglaLPLLWALLGEGGSLLLPRGGLGALPDALAAqllGGDVRLNTRVRSIDREGDGVTVTLTDG 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 625 TGYSAQKVLVTVPLALLQkgAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDsKVQGADFFGHVPPSASKRGLFA 704
Cdd:pfam01593 245 EVIEADAVIVTVPLGVLK--RILFTPPLPPEKARAIRNLGYGPVNKVHLEFDRKFWP-DLGLLGLLSELLTGLGTAFSWL 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 705 VFYDMDPQKKHSVLMS-VIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGG 783
Cdd:pfam01593 322 TFPNRAPPGKGLLLLVyVGPGDRARELEGLSDEELLQAVLRDLRKLFGE-EAPEPLRVLVSDWHTDPWPRGSYSLPQYGP 400

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1034649026 784 SGEAYDIIAEDIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:pfam01593 401 GHDDYRPLARTPDPGLFFAGEHTSTGYPGTVEGAIESGRRAARAV 445
YobN COG1231
Monoamine oxidase [Amino acid transport and metabolism];
408-830 9.43e-75

Monoamine oxidase [Amino acid transport and metabolism];


Pssm-ID: 440844 [Multi-domain]  Cd Length: 440  Bit Score: 250.61  E-value: 9.43e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 408 RQLHNFGIKVTVLEAKDRIGGRVW-DDKSFKGVTVGRGAQIVNGcinNPVALM--CEQLGISMHKFGERCD---LIQEGG 481
Cdd:COG1231    24 RELRKAGLDVTVLEARDRVGGRVWtLRFGDDGLYAELGAMRIPP---SHTNLLalARELGLPLEPFPNENGnalLYLGGK 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 482 RITDPTIDKRMDFHF-------NALLDVVSEWRKDKTQLQDVPLGEkieeiykaFIKESGIQFSelegqVLQFHLSNLEY 554
Cdd:COG1231   101 RVRAGEIAADLRGVAellakllRALAAALDPWAHPAAELDRESLAE--------WLRRNGASPS-----ARRLLGLLGAG 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 555 ACGSNLHQVSARSWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGL--DIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKV 632
Cdd:COG1231   168 EYGADPDELSLLDLLRYAASAGGGAQQFRIVGGMDQLPRALAAELgdRIRLGAPVTRIRQDGDGVTVTTDDGGTVRADAV 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 633 LVTVPLALLQKgaIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFW--DSKVQGADFfghvppsaSKRGLFAVFYDMD 710
Cdd:COG1231   248 IVTVPPSVLRR--IEFDPPLPAAKRAAIQRLPYGAAIKVFLQFDRPFWeeDGLYGGISL--------TDLPIRQTWYPSN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 711 PQ-KKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEqEVPDPTKYFVTRWSTDPWIQMAYSFVKTGGSGEAYD 789
Cdd:COG1231   318 GPdGGAGVLLGYVGGDDARALAALSPEERVAAALEQLARIFGV-YAAEPVDYVSTDWGRDPWSRGAYAAAPPGQLTAAGP 396

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1034649026 790 IIAEdIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAA 830
Cdd:COG1231   397 ALAE-PDGRIHFAGEHTSDEWPGWVEGALESGERAAAEILA 436
PLN02268 PLN02268
probable polyamine oxidase
 393-828 3.93e-70

probable polyamine oxidase


Pssm-ID: 177909 [Multi-domain]  Cd Length: 435  Bit Score: 238.05  E-value: 3.93e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 393 SVIIIGAGPAGLAAARQLHNFGIKVTVLEAKDRIGGRVWDDKSFkGVTVGRGAQIVNG-CINNPVALMCEQLGISMHKFG 471
Cdd:PLN02268    2 SVIVIGGGIAGIAAARALHDASFKVTLLESRDRIGGRVHTDYSF-GFPVDMGASWLHGvCNENPLAPLIGRLGLPLYRTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 472 -----------ERCDLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDktQLQDVPLGEKIEEIYK--AFIKESGIQFs 538
Cdd:PLN02268   81 gdnsvlydhdlESYALFDMDGNQVPQELVTKVGETFERILEETEKVRDE--HEEDMSLLQAISIVLErhPELRLEGLAH- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 539 elegQVLQFHLSNLEYACGSNLHQVSARSWDHNEFFAqfaGDHTLLTPGYSVIIEKLAEGLDIQLKSPVQCIDYSGDEVQ 618
Cdd:PLN02268  158 ----EVLQWYLCRMEGWFAADADTISLKSWDQEELLE---GGHGLMVRGYDPVINTLAKGLDIRLNHRVTKIVRRYNGVK 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 619 VTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSkvqgADFFGHVPPSAS 698
Cdd:PLN02268  231 VTVEDGTTFVADAAIIAVPLGVLKANIIKFEPELPEWKEEAISDLGVGIENKIALHFDSVFWPN----VEFLGVVAPTSY 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 699 KRGLfavFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKeqEVPDPTKYFVTRWSTDPWIQMAYSF 778
Cdd:PLN02268  307 GCSY---FLNLHKATGHPVLVYMPAGRLARDIEKLSDEAAANFAMSQLKKMLP--DATEPVQYLVSRWGSDPNSLGCYSY 381

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034649026 779 VKTGGSGEAYDIIAEDIqGTVFFAGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:PLN02268  382 DLVGKPHDLYERLRAPV-DNLFFAGEATSSDFPGSVHGAYSTGVMAAEEC 430
PLN02676 PLN02676
polyamine oxidase
 393-828 7.80e-42

polyamine oxidase


Pssm-ID: 215362 [Multi-domain]  Cd Length: 487  Bit Score: 159.88  E-value: 7.80e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 393 SVIIIGAGPAGLAAARQLHNFGIK-VTVLEAKDRIGGRVwDDKSFKGVTVGRGA---QIVNGCINNPVALMCEQLGISMh 468
Cdd:PLN02676   28 SVIIVGAGMSGISAAKTLSEAGIEdILILEATDRIGGRM-RKANFAGVSVELGAnwvEGVGGPESNPIWELANKLKLRT- 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 469 kFGERCDLI------QEGGRITDPTIDKRMDfhfnaLLDVVSEW------RKDKTQLQDVPLgEKIEEIYKAFIKesgiq 536
Cdd:PLN02676  106 -FYSDFDNLssniykQDGGLYPKKVVQKSMK-----VADASDEFgenlsiSLSAKKAVDISI-LTAQRLFGQVPK----- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 537 fSELEgQVLQFHLSNLEYAcgSNLHQVSARSWDHNEFFAQFAGDHTLLTP--GYSVIIEKLAEG---------LD--IQL 603
Cdd:PLN02676  174 -TPLE-MVIDYYNYDYEFA--EPPRVTSLKNTEPNPTFVDFGEDEYFVADprGYESLVYYLAEQflstksgkiTDprLKL 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 604 KSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSK 683
Cdd:PLN02676  250 NKVVREISYSKNGVTVKTEDGSVYRAKYVIVSVSLGVLQSDLIKFKPPLPDWKIEAIYQFDMAVYTKIFLKFPYKFWPSG 329

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 684 vQGADFFGHvppSASKRGLFAVFYDMDPQKKHS--VLMSVIAGEAvASVRTLDDKQVLQQCMATLRELFKEQeVPDPTKY 761
Cdd:PLN02676  330 -PGTEFFLY---AHERRGYYPFWQHLENEYPGSnvLFVTVTDEES-RRIEQQPDSETKAEIMEVLRKMFGPN-IPEATDI 403

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034649026 762 FVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIqGTVFFAGEATNRHFPQTVTGAYLSGVrEASKI 828
Cdd:PLN02676  404 LVPRWWSNRFFKGSYSNWPIGVSRYEFDQIRAPV-GRVYFTGEHTSEKYNGYVHGAYLAGI-DTAND 468
PLN02568 PLN02568
polyamine oxidase
 416-828 1.03e-38

polyamine oxidase


Pssm-ID: 215308 [Multi-domain]  Cd Length: 539  Bit Score: 151.91  E-value: 1.03e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 416 KVTVLEAKDRIGGRVwDDKSFKGVTVGRGAQIVNGCINNPV--------ALMCEQLGISMHKFGERCDLIQEGGRITDPT 487
Cdd:PLN02568   35 ELTVVEGGDRIGGRI-NTSEFGGERIEMGATWIHGIGGSPVykiaqeagSLESDEPWECMDGFPDRPKTVAEGGFEVDPS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 488 IDKRMDFHFNALLDVVSEWRKDKTQLQDVPLGEKIE----------------------EIYKAFIKE-------SGIQFS 538
Cdd:PLN02568  114 IVESISTLFRGLMDDAQGKLIEPSEVDEVDFVKLAAkaarvcesggggsvgsflrrglDAYWDSVSAdeqikgyGGWSRK 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 539 ELEGQVLQFHlSNLE--YACGSNLHQVSarsWDHNEFFAQFAGDHTLLTPGYSVIIEKLAEGLD---IQLKSPVQCIDYS 613
Cdd:PLN02568  194 LLEEAIFTMH-ENTQrtYTSADDLSTLD---LAAESEYRMFPGEEITIAKGYLSVIEALASVLPpgtIQLGRKVTRIEWQ 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 614 GDEVQVTTTDGTGYSAQKVLVTVPLALLQKGAIQ----FNPPLSEKKMKAINSLGAGIIEKIALQFPYRFwDSKVQGAD- 688
Cdd:PLN02568  270 DEPVKLHFADGSTMTADHVIVTVSLGVLKAGIGEdsglFSPPLPDFKTDAISRLGFGVVNKLFVELSPRP-DGSPEDVAk 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 689 -------FFGHVPPSASK------RGLFAVFydmdP-QKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMATLRELFKEQE 754
Cdd:PLN02568  349 fpflqmaFHRSDSEARHDkipwwmRRTASIC----PiHKNSSVLLSWFAGKEALELEKLSDEEIIRGVQTTLSSFLKRRV 424

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 755 VPDP---------------------TKYFVTRWSTDPWIQMAYSFVKTGGSGEAYDIIAEDIQGT------------VFF 801
Cdd:PLN02568  425 AGLGsqshplcnggassndgsrwkfVKVLKSKWGTDPLFLGSYSYVAVGSSGDDLDRMAEPLPRIsdhdqaggpplqLLF 504

                         490       500
                  ....*....|....*....|....*..
gi 1034649026 802 AGEATNRHFPQTVTGAYLSGVREASKI 828
Cdd:PLN02568  505 AGEATHRTHYSTTHGAYFSGLREANRL 531
zf-CW pfam07496
CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four ...
 138-200 3.67e-08

CW-type Zinc Finger; This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by, and is predicted to be a "highly specialized mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including...chromatin methylation status and early embryonic development." Weak homology to pfam00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteriztic of vertebrates, higher plants and other animals in which these domain is found.


Pssm-ID: 462181  Cd Length: 46  Bit Score: 50.00  E-value: 3.67e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034649026 138 YWVQCTKpeCRKWRQLTKEIQlTPQIAKTYRCGMKPNTAIKRrgfavlprpetsdhCSLPEDL 200
Cdd:pfam07496   1 YWVQCDS--CLKWRRLPTEID-PYELPEPWYCSMNPDPKYNS--------------CDAPEEI 46
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 403-766 4.82e-08

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 56.38  E-value: 4.82e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 403 GLAAARQLHNFGIKVTVLEAKDRIGGRVwddKSF--KGVTVGRGAQIVngCINNPVAL-MCEQLGIS--MHKFGERCDLI 477
Cdd:COG1232    13 GLTAAYRLAKAGHEVTVLEASDRVGGLI---RTVevDGFRIDRGPHSF--LTRDPEVLeLLRELGLGdeLVWPNTRKSYI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 478 QEGGRITD-PTidKRMDFHFNALLDVVSEWR-------KDKTQLQDVPLGEKI-----EEIYKAFIKE--SGIqFS---- 538
Cdd:COG1232    88 YYGGKLHPlPQ--GPLALLRSPLLSLAGKLRallellaPRRPPGEDESLAEFVrrrfgREVYERLVEPllEGV-YAgdpd 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 539 ELEGQ-VLQFhLSNLEYACGSNLHQVSA--RSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGL---DIQLKSPVQCIDY 612
Cdd:COG1232   165 ELSADwAFPR-LKRLELEHGSLIKGALAlrKGAKAGEVFGYLRG-------GLGTLVEALAEALeagEIRLGTRVTAIER 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 613 SGDEVQVTTTDGTGYSAQKVLVTVPLALLQKgAIQFNPPLSEKKMKAINSLGAGIiekIALQFPyrfwDSKVQGADFFGH 692
Cdd:COG1232   237 EGGGWRVTTSDGETIEADAVVSATPAPALAR-LLAPLPPEVAAALAGIPYASVAV---VALGFD----RPDLPPPDGFGW 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 693 VPPSASKRGLFAVFY------DMDPQKKHSVLMSvIAGEAVASVRTLDDKQVLQQCMATLRELFKEQevPDPTKYFVTRW 766
Cdd:COG1232   309 LVPRDEGVPILAVTFssnkwpHRAPDGKVLLRLE-VGGAGDPELWQLSDEELVALALADLRKLLGID--AEPVDTRVVRW 385
PRK07233 PRK07233
hypothetical protein; Provisional
 587-665 2.85e-07

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 53.74  E-value: 2.85e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 587 GYSVIIEKLAE-----GLDIQLKSPVQCIDYSGDEVQVTTTDGTGYSAQKVLVTVPLALLQKgaiqFNPPLSEK---KMK 658
Cdd:PRK07233  196 GFATLIDALAEaiearGGEIRLGTPVTSVVIDGGGVTGVEVDGEEEDFDAVISTAPPPILAR----LVPDLPADvlaRLR 271


                  ....*..
gi 1034649026 659 AINSLGA 665
Cdd:PRK07233  272 RIDYQGV 278
SWIRM pfam04433
SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid ...
 301-372 5.62e-05

SWIRM domain; This SWIRM domain is a small alpha-helical domain of about 85 amino acid residues found in chromosomal proteins. It contains a helix-turn helix motif and binds to DNA.


Pssm-ID: 461307 [Multi-domain]  Cd Length: 78  Bit Score: 42.16  E-value: 5.62e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034649026 301 DELYEFPEY----SRDPTMYLALRNLILALWYTNCKEALTPQKCiphiivRGLVRIrCVQEVERILYFMTRKGLIN 372
Cdd:pfam04433   9 IEKRLLPEFfngkSKTPEVYLEIRNFILNLWRENPKEYLTKTDA------RRALKG-DVNLISRIHEFLERWGLIN 77
proto_IX_ox TIGR00562
protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a ...
 414-785 3.10e-04

protoporphyrinogen oxidase; This enzyme oxidizes protoporphyrinogen IX to protoporphyrin IX, a precursor of heme and chlorophyll. Bacillus subtilis HemY also has coproporphyrinogen III to coproporphyrin III oxidase activity in a heterologous expression system, although the role for this activity in vivo is unclear. This protein is a flavoprotein and has a beta-alpha-beta dinucleotide binding motif near the amino end. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 213540 [Multi-domain]  Cd Length: 462  Bit Score: 44.06  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 414 GIKVTVLEAKDRIGGRVWDDKSfKGVTVGRGAQIVNGcINNPVALMCEQLGIS----MHKFGERCDLIQEGGRITDPT-I 488
Cdd:TIGR00562  29 PVELTLVEASDRVGGKIQTVKE-DGYLIERGPDSFLE-RKKSAPDLVKDLGLEhvlvSDATGQRYVLVNRGKLMPVPTkI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 489 DKRMDFHFNAL---LDVVSEWRKDKTQLQDVPLG---------EKIEEIYKAFIkeSGIQFSELEGQVL-----QFHLSN 551
Cdd:TIGR00562 107 APFVKTGLFSLggkLRAGMDFIRPASPGKDESVEefvrrrfgdEVVENLIEPLL--SGIYAGDPSKLSLkstfpKFYQTE 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 552 LEYacGS---------NLHQvSARSWDHNEFFAQFAGdhtlltpGYSVIIEKLAEGLDIQLK-------SPVQCIDYSGD 615
Cdd:TIGR00562 185 QKH--GSlilgmkktrNLPQ-GSGLQLTAKKQGQDFQ-------TLATGLETLPEEIEKRLKltkvykgTKVTKLSHRGS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 616 EVQVTTTDGTGYSAQKVLVTVPlallQKGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGadfFGHVPP 695
Cdd:TIGR00562 255 NYTLELDNGVTVETDSVVVTAP----HKAAAGLLSELSNSASSHLDKIHSPPVANVNLGFPEGSVDGELEG---FGFLIS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034649026 696 SASKRGLFAVFYD------MDPQKKhSVLMSVIAGEAVASVRTLDDKQVLQqcmATLRELFKEQEVP-DPTKYFVTRWST 768
Cdd:TIGR00562 328 RSSKFAILGCIFTsklfpnRAPPGK-TLLTAYIGGATDESIVDLSENEIIN---IVLRDLKKVLNINnEPEMLCVTRWHR 403

                         410       420
                  ....*....|....*....|....*.
gi 1034649026 769 ---------DPWIQMAYSFVKTGGSG 785
Cdd:TIGR00562 404 aipqyhvghDQRLKEARELLESAYPG 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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