|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
50-442 |
5.65e-47 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 167.51 E-value: 5.65e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 50 LADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGA 129
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 130 VFLWD--SGSSVGEITGHNKVINSVDIKQSRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATA 207
Cdd:cd00200 75 IRLWDleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 208 SADGQtrrqspvnaclllnhtgslvceprfstatvhgetaysrgcshthdphvfiswkIYIYDGKTGEKVCALGGskaHD 287
Cdd:cd00200 154 SQDGT-----------------------------------------------------IKLWDLRTGKCVATLTG---HT 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 288 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVnsvvstfpmgstvldqqlgclwqkdhllsvslsgyinyldrnnpSKPLH 367
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLST--------------------------------------------GKCLG 213
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034641966 368 VIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVR 442
Cdd:cd00200 214 TLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGKrLASGSADGTIR 286
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-442 |
7.58e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 167.78 E-value: 7.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319 60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 120 VGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIkqsRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 196 RFSPDGNRFATASADGQTRrqspvnaclllnhtgslvceprfstatvhgetaysrgcshthdphvfiswkiyIYDGKTGE 275
Cdd:COG2319 211 AFSPDGKLLASGSADGTVR-----------------------------------------------------LWDLATGK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 276 KVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGStvlDQQLGCLWQKD--HLLSVSLSGY 353
Cdd:COG2319 238 LLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS---GGVNSVAFSPDgkLLASGSDDGT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 354 INYLDRNNPsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGENDSFAgKGHTNQVSRMTVDESGQ-L 432
Cdd:COG2319 312 VRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRtL 387
|
410
....*....|
gi 1034641966 433 ISCSMDDTVR 442
Cdd:COG2319 388 ASGSADGTVR 397
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
161-658 |
5.61e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 159.69 E-value: 5.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 161 RLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQTRRQSPVNACLLLNHTGSLVcEPRFSTA 240
Cdd:COG2319 8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-AVLSVAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 241 TVHGETAYSRGCSHThdphvfiswkIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvns 320
Cdd:COG2319 87 SPDGRLLASASADGT----------VRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 321 vvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHIN 400
Cdd:COG2319 151 ------------------------------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 401 YWDSETGEnDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCi 479
Cdd:COG2319 188 LWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS- 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 480 gqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 559
Cdd:COG2319 252 ------------------------VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 560 CDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL- 638
Cdd:COG2319 306 GSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSp 382
|
490 500
....*....|....*....|
gi 1034641966 639 DEHTLVTTSHDASVKEWTIT 658
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
284-612 |
1.11e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 136.31 E-value: 1.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 284 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFpMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPs 363
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 364 KPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGENdSFAGKGHTNQVSRMTVDESGQLISCSMDDtvry 443
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQD---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 444 tslmlrdysgqGVVKL-DV-QPKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGN 521
Cdd:cd00200 157 -----------GTIKLwDLrTGKCVATLTGHTGEVNS-------------------------VAFSPDGEKLLSSSSDGT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 522 VRLYSILGTTLKdegKLLEAK-GPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHF 600
Cdd:cd00200 201 IKLWDLSTGKCL---GTLRGHeNGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRL 276
|
330
....*....|..
gi 1034641966 601 ASGGMDMMVYVW 612
Cdd:cd00200 277 ASGSADGTIRIW 288
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
284-315 |
1.52e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 1.52e-06
10 20 30
....*....|....*....|....*....|..
gi 1034641966 284 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 315
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
579-612 |
2.35e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 44.61 E-value: 2.35e-06
10 20 30
....*....|....*....|....*....|....
gi 1034641966 579 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 612
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
284-315 |
7.96e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.10 E-value: 7.96e-06
10 20 30
....*....|....*....|....*....|..
gi 1034641966 284 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 315
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
580-612 |
1.26e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 42.33 E-value: 1.26e-05
10 20 30
....*....|....*....|....*....|...
gi 1034641966 580 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 612
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
70-434 |
3.14e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.39 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 70 GFYIASGDVSGKLRIWD---TTQKEHLLKYEYQPFAG--KIKDIAWTEDSKRiAVVGEGREkfGAVFLWDSGSS--VGEI 142
Cdd:PLN00181 495 GEFFATAGVNKKIKIFEcesIIKDGRDIHYPVVELASrsKLSGICWNSYIKS-QVASSNFE--GVVQVWDVARSqlVTEM 571
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 143 TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRFATASADgqtrrqspvna 221
Cdd:PLN00181 572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSAD----------- 639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 222 clllnHtgslvceprfstatvhgetaysrgcshthdphvfiswKIYIYDGKTGE-KVCALGGskaHDGGIYAISWSpDST 300
Cdd:PLN00181 640 -----H-------------------------------------KVYYYDLRNPKlPLCTMIG---HSKTVSYVRFV-DSS 673
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 301 HLLSASGDKTSKIWDvsvnsvvstfpmgstvldqqlgclwqkdhlLSVSLSGyINyldrnnpSKPLHVIKGHS--KSIQC 378
Cdd:PLN00181 674 TLVSSSTDNTLKLWD------------------------------LSMSISG-IN-------ETPLHSFMGHTnvKNFVG 715
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034641966 379 LTVhkngGKSYIYSGSHDGHI-NYWDSETGENDSFAGKgHTNQVSRMTVDESGQLIS 434
Cdd:PLN00181 716 LSV----SDGYIATGSETNEVfVYHKAFPMPVLSYKFK-TIDPVSGLEVDDASQFIS 767
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
513-658 |
8.67e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.38 E-value: 8.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 513 VAIGGVDGNVRLYSILGTTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 591
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034641966 592 AWSPDN-EHFASGGMDMMVYVWTLSDPETRVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 658
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
50-442 |
5.65e-47 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 167.51 E-value: 5.65e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 50 LADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRIAVVGEgrekFGA 129
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTLKGHTGPVRDVAASADGTYLASGSS----DKT 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 130 VFLWD--SGSSVGEITGHNKVINSVDIKQSRPYrLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATA 207
Cdd:cd00200 75 IRLWDleTGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 208 SADGQtrrqspvnaclllnhtgslvceprfstatvhgetaysrgcshthdphvfiswkIYIYDGKTGEKVCALGGskaHD 287
Cdd:cd00200 154 SQDGT-----------------------------------------------------IKLWDLRTGKCVATLTG---HT 177
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 288 GGIYAISWSPDSTHLLSASGDKTSKIWDVSVnsvvstfpmgstvldqqlgclwqkdhllsvslsgyinyldrnnpSKPLH 367
Cdd:cd00200 178 GEVNSVAFSPDGEKLLSSSSDGTIKLWDLST--------------------------------------------GKCLG 213
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034641966 368 VIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVR 442
Cdd:cd00200 214 TLRGHENGVNSVAFSPDG--YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGKrLASGSADGTIR 286
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-442 |
7.58e-46 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 167.78 E-value: 7.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319 60 LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLR--TLTGHTGAVRSVAFSPDGKTLAS 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 120 VGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIkqsRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 138 GSAD----GTVRLWDlaTGKLLRTLTGHSGAVTSVAF---SPdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 196 RFSPDGNRFATASADGQTRrqspvnaclllnhtgslvceprfstatvhgetaysrgcshthdphvfiswkiyIYDGKTGE 275
Cdd:COG2319 211 AFSPDGKLLASGSADGTVR-----------------------------------------------------LWDLATGK 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 276 KVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGStvlDQQLGCLWQKD--HLLSVSLSGY 353
Cdd:COG2319 238 LLRTLTG---HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHS---GGVNSVAFSPDgkLLASGSDDGT 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 354 INYLDRNNPsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGENDSFAgKGHTNQVSRMTVDESGQ-L 432
Cdd:COG2319 312 VRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG--KTLASGSDDGTVRLWDLATGELLRTL-TGHTGAVTSVAFSPDGRtL 387
|
410
....*....|
gi 1034641966 433 ISCSMDDTVR 442
Cdd:COG2319 388 ASGSADGTVR 397
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
161-658 |
5.61e-43 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 159.69 E-value: 5.61e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 161 RLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQTRRQSPVNACLLLNHTGSLVcEPRFSTA 240
Cdd:COG2319 8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTA-AVLSVAF 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 241 TVHGETAYSRGCSHThdphvfiswkIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvns 320
Cdd:COG2319 87 SPDGRLLASASADGT----------VRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 321 vvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHIN 400
Cdd:COG2319 151 ------------------------------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVR 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 401 YWDSETGEnDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCi 479
Cdd:COG2319 188 LWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS- 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 480 gqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 559
Cdd:COG2319 252 ------------------------VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 560 CDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL- 638
Cdd:COG2319 306 GSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSp 382
|
490 500
....*....|....*....|
gi 1034641966 639 DEHTLVTTSHDASVKEWTIT 658
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLA 402
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
67-616 |
1.16e-40 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 153.14 E-value: 1.16e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 67 APSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAVVGEGREkfGAVFLWDSGSSVGEITGHN 146
Cdd:COG2319 3 SADGAALAAASADLALALLAAALGALLL--LLLGLAAAVASLAASPDGARLAAGAGDLT--LLLLDAAAGALLATLLGHT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 147 KVINSVDIKQSRPyRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGqtrrqspvnacllln 226
Cdd:COG2319 79 AAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 227 htgslvceprfstatvhgetaysrgcshthdphvfiswKIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSAS 306
Cdd:COG2319 143 --------------------------------------TVRLWDLATGKLLRTLTG---HSGAVTSVAFSPDGKLLASGS 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 307 GDKTSKIWDVSvnsvvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGg 386
Cdd:COG2319 182 DDGTVRLWDLA---------------------------------TG-----------KLLRTLTGHTGAVRSVAFSPDG- 216
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 387 kSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRytslmLRDYSGQgvvkldvqpKC 465
Cdd:COG2319 217 -KLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVR-----LWDLATG---------EL 280
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 466 VAVGPGGYAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgttlkDEGKLLEA---- 541
Cdd:COG2319 281 LRTLTGHSGGVNS-------------------------VAFSPDGKLLASGSDDGTVRLWDL------ATGKLLRTltgh 329
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034641966 542 KGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSD 616
Cdd:COG2319 330 TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
COG2319 |
WD40 repeat [General function prediction only]; |
40-573 |
1.99e-39 |
|
WD40 repeat [General function prediction only];
Pssm-ID: 441893 [Multi-domain] Cd Length: 403 Bit Score: 149.68 E-value: 1.99e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 40 VILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEHLLkyEYQPFAGKIKDIAWTEDSKRIAV 119
Cdd:COG2319 18 LALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA--TLLGHTAAVLSVAFSPDGRLLAS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 120 VGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIkqsRP--YRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:COG2319 96 ASAD----GTVRLWDlaTGLLLRTLTGHTGAVRSVAF---SPdgKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 196 RFSPDGNRFATASADGQtrrqspvnaclllnhtgslvceprfstatvhgetaysrgcshthdphvfiswkIYIYDGKTGE 275
Cdd:COG2319 169 AFSPDGKLLASGSDDGT-----------------------------------------------------VRLWDLATGK 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 276 KVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVsvnsvvstfpmgstvldqqlgclwqkdhllsvslsgyin 355
Cdd:COG2319 196 LLRTLTG---HTGAVRSVAFSPDGKLLASGSADGTVRLWDL--------------------------------------- 233
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 356 yldrnNPSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGENDSFAGkGHTNQVSRMTVDESGQ-LIS 434
Cdd:COG2319 234 -----ATGKLLRTLTGHSGSVRSVAFSPDG--RLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKlLAS 305
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 435 CSMDDTVRytslmLRDYSGqgvvkldvqPKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVA 514
Cdd:COG2319 306 GSDDGTVR-----LWDLAT---------GKLLRTLTGHTGAVRS-------------------------VAFSPDGKTLA 346
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*....
gi 1034641966 515 IGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVAD 573
Cdd:COG2319 347 SGSDDGTVRLWDL--ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
284-612 |
1.11e-35 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 136.31 E-value: 1.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 284 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFpMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPs 363
Cdd:cd00200 6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 364 KPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGENdSFAGKGHTNQVSRMTVDESGQLISCSMDDtvry 443
Cdd:cd00200 84 ECVRTLTGHTSYVSSVAFSPDG--RILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQD---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 444 tslmlrdysgqGVVKL-DV-QPKCVAVGPGGYAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGN 521
Cdd:cd00200 157 -----------GTIKLwDLrTGKCVATLTGHTGEVNS-------------------------VAFSPDGEKLLSSSSDGT 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 522 VRLYSILGTTLKdegKLLEAK-GPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHF 600
Cdd:cd00200 201 IKLWDLSTGKCL---GTLRGHeNGVNSVAFSPDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRL 276
|
330
....*....|..
gi 1034641966 601 ASGGMDMMVYVW 612
Cdd:cd00200 277 ASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
365-655 |
1.33e-28 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 115.90 E-value: 1.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 365 PLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSR-MTVDESGQLISCSMDDTVRY 443
Cdd:cd00200 1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 444 TSL----MLRDYSG--QGVVKLDVQPKC-VAVGpGGYAVVVCIGQIVLLKDQRKCFSIDNPGYepeVVAVHPGGDTVAIG 516
Cdd:cd00200 78 WDLetgeCVRTLTGhtSYVSSVAFSPDGrILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVN---SVAFSPDGTFVASS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 517 GVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPD 596
Cdd:cd00200 154 SQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPD 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 597 NEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEW 655
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLS-GHT-NSVTSLAWSpDGKRLASGSADGTIRIW 288
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
38-315 |
3.74e-26 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 108.96 E-value: 3.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 38 KCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGKIKDIAWTEDSKRI 117
Cdd:cd00200 73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTLRGHTDWVNSVAFSPDGTFV 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 118 AVVGEGrekfGAVFLWD--SGSSVGEITGHNKVINSVDIKQSRpYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCV 195
Cdd:cd00200 151 ASSSQD----GTIKLWDlrTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 196 RFSPDGNRFATASADGqtrrqspvnaclllnhtgslvceprfstatvhgetaysrgcshthdphvfiswKIYIYDGKTGE 275
Cdd:cd00200 226 AFSPDGYLLASGSEDG-----------------------------------------------------TIRVWDLRTGE 252
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1034641966 276 KVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWD 315
Cdd:cd00200 253 CVQTLSG---HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
284-315 |
1.52e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 45.00 E-value: 1.52e-06
10 20 30
....*....|....*....|....*....|..
gi 1034641966 284 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 315
Cdd:smart00320 9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
579-612 |
2.35e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 44.61 E-value: 2.35e-06
10 20 30
....*....|....*....|....*....|....
gi 1034641966 579 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 612
Cdd:smart00320 6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
362-403 |
5.96e-06 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 43.46 E-value: 5.96e-06
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 1034641966 362 PSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWD 403
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDG--KYLASGSDDGTIKLWD 40
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
284-315 |
7.96e-06 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 43.10 E-value: 7.96e-06
10 20 30
....*....|....*....|....*....|..
gi 1034641966 284 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 315
Cdd:pfam00400 8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
580-612 |
1.26e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 42.33 E-value: 1.26e-05
10 20 30
....*....|....*....|....*....|...
gi 1034641966 580 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 612
Cdd:pfam00400 6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
|
|
| WD40 |
smart00320 |
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ... |
178-214 |
1.46e-05 |
|
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.
Pssm-ID: 197651 [Multi-domain] Cd Length: 40 Bit Score: 42.30 E-value: 1.46e-05
10 20 30
....*....|....*....|....*....|....*..
gi 1034641966 178 PFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQTR 214
Cdd:smart00320 1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIK 37
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
363-403 |
1.98e-05 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 41.95 E-value: 1.98e-05
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 1034641966 363 SKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWD 403
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTVKVWD 39
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
70-434 |
3.14e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.39 E-value: 3.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 70 GFYIASGDVSGKLRIWD---TTQKEHLLKYEYQPFAG--KIKDIAWTEDSKRiAVVGEGREkfGAVFLWDSGSS--VGEI 142
Cdd:PLN00181 495 GEFFATAGVNKKIKIFEcesIIKDGRDIHYPVVELASrsKLSGICWNSYIKS-QVASSNFE--GVVQVWDVARSqlVTEM 571
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 143 TGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFKFTIGDHSRfVNCVRFSPD-GNRFATASADgqtrrqspvna 221
Cdd:PLN00181 572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSEsGRSLAFGSAD----------- 639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 222 clllnHtgslvceprfstatvhgetaysrgcshthdphvfiswKIYIYDGKTGE-KVCALGGskaHDGGIYAISWSpDST 300
Cdd:PLN00181 640 -----H-------------------------------------KVYYYDLRNPKlPLCTMIG---HSKTVSYVRFV-DSS 673
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 301 HLLSASGDKTSKIWDvsvnsvvstfpmgstvldqqlgclwqkdhlLSVSLSGyINyldrnnpSKPLHVIKGHS--KSIQC 378
Cdd:PLN00181 674 TLVSSSTDNTLKLWD------------------------------LSMSISG-IN-------ETPLHSFMGHTnvKNFVG 715
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1034641966 379 LTVhkngGKSYIYSGSHDGHI-NYWDSETGENDSFAGKgHTNQVSRMTVDESGQLIS 434
Cdd:PLN00181 716 LSV----SDGYIATGSETNEVfVYHKAFPMPVLSYKFK-TIDPVSGLEVDDASQFIS 767
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
187-419 |
3.57e-05 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 47.00 E-value: 3.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 187 DHSRFVNCVRFSPDGNRFATASadgqtrrqspVNACLLLNHTGSLVCEPR---FSTATVHGETAYSRGCSHTHDPHVFIS 263
Cdd:PLN00181 481 NSSNLVCAIGFDRDGEFFATAG----------VNKKIKIFECESIIKDGRdihYPVVELASRSKLSGICWNSYIKSQVAS 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 264 WK----IYIYDGKTGEKVCALggsKAHDGGIYAISWSP-DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGC 338
Cdd:PLN00181 551 SNfegvVQVWDVARSQLVTEM---KEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPS 627
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 339 LWQKDhLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLtvhKNGGKSYIYSGSHDGHINYWD---SETGENDS--FA 413
Cdd:PLN00181 628 ESGRS-LAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYV---RFVDSSTLVSSSTDNTLKLWDlsmSISGINETplHS 703
|
....*.
gi 1034641966 414 GKGHTN 419
Cdd:PLN00181 704 FMGHTN 709
|
|
| WD40 |
pfam00400 |
WD domain, G-beta repeat; |
179-214 |
3.97e-04 |
|
WD domain, G-beta repeat;
Pssm-ID: 459801 [Multi-domain] Cd Length: 39 Bit Score: 38.10 E-value: 3.97e-04
10 20 30
....*....|....*....|....*....|....*.
gi 1034641966 179 FKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQTR 214
Cdd:pfam00400 1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVK 36
|
|
| PLN00181 |
PLN00181 |
protein SPA1-RELATED; Provisional |
513-658 |
8.67e-04 |
|
protein SPA1-RELATED; Provisional
Pssm-ID: 177776 [Multi-domain] Cd Length: 793 Bit Score: 42.38 E-value: 8.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 513 VAIGGVDGNVRLYSILGTTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 591
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034641966 592 AWSPDN-EHFASGGMDMMVYVWTLSDPETRVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 658
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
|
|
| WD40 |
cd00200 |
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ... |
26-122 |
2.25e-03 |
|
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.
Pssm-ID: 238121 [Multi-domain] Cd Length: 289 Bit Score: 40.40 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034641966 26 DPKGNNFLYTNG-KCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEhlLKYEYQPFAGK 104
Cdd:cd00200 186 SPDGEKLLSSSSdGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE--CVQTLSGHTNS 263
|
90
....*....|....*...
gi 1034641966 105 IKDIAWTEDSKRIAVVGE 122
Cdd:cd00200 264 VTSLAWSPDGKRLASGSA 281
|
|
| |
