OCRE domain found in angiogenic factor VG5Q and similar proteins; VG5Q, also called angiogenic factor with G patch and FHA domains 1 (AGGF1), or G patch domain-containing protein 7, or vasculogenesis gene on 5q protein, functions as a potent angiogenic factor in promoting angiogenesis through interacting with TWEAK (also known as TNFSF12), which is a member of the tumor necrosis factor (TNF) superfamily that induces angiogenesis in vivo. VG5Q can bind to the surface of endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. The chromosomal translocation t(5;11) and the E133K variant in VG5Q are associated with Klippel-Trenaunay syndrome (KTS), a disorder characterized by diverse effects in the vascular system. In addition to a forkhead-associated (FHA) domain and a G-patch motif, VG5Q contains an N-terminal OCtamer REpeat (OCRE) domain that is characterized by a 5-fold, imperfectly repeated octameric sequence.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1016683080 199 AAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 252
Cdd:cd16164     1 AAVSQSGFVYDEATGMYYDPSTGYYYDSETQLYYDPNTGTYYYYDEESGSYQFH 54

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1016683080  21 LAQLRRKVEKLERELRSCKRQV-------REIEKLLHHTERL---YQSAESNNRELRTQVEELSKILY 78
Cdd:COG2433   436 LEEKDERIERLERELSEARSEErreirkdREISRLDREIERLereLEEERERIEELKRKLERLKELWK 503

OCRE domain found in angiogenic factor VG5Q and similar proteins; VG5Q, also called angiogenic factor with G patch and FHA domains 1 (AGGF1), or G patch domain-containing protein 7, or vasculogenesis gene on 5q protein, functions as a potent angiogenic factor in promoting angiogenesis through interacting with TWEAK (also known as TNFSF12), which is a member of the tumor necrosis factor (TNF) superfamily that induces angiogenesis in vivo. VG5Q can bind to the surface of endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. The chromosomal translocation t(5;11) and the E133K variant in VG5Q are associated with Klippel-Trenaunay syndrome (KTS), a disorder characterized by diverse effects in the vascular system. In addition to a forkhead-associated (FHA) domain and a G-patch motif, VG5Q contains an N-terminal OCtamer REpeat (OCRE) domain that is characterized by a 5-fold, imperfectly repeated octameric sequence.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1016683080 199 AAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 252
Cdd:cd16164     1 AAVSQSGFVYDEATGMYYDPSTGYYYDSETQLYYDPNTGTYYYYDEESGSYQFH 54

OCRE domain; The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts. The structure of the domain consists of an anti-parallel arrangement of six beta strands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1016683080 202 SQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 252
Cdd:pfam17780   1 DSSGYVYDEASGYYYDPTTGYYYDPNTGLYYDPATGKYYTYDEETKSYVPH 51

Forkhead associated domain; Found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1016683080  434 TIGREKDmEHTLRIPEVGVSKFHAEIYFDHDLqSYVLVDQGSQNGTVVNGKQI 486
Cdd:smart00240   2 TIGRSSE-DCDIQLDGPSISRRHAVIVYDGGG-RFYLIDLGSTNGTFVNGKRI 52

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1016683080 619 SNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLG 660
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43

Protein of unknown function (DUF745); This family consists of several uncharacterized Drosophila melanogaster proteins of unknown function.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1016683080  28 VEKLERELRSCKRQVREIEKLLHHTERLYQSAESNNRELRTQVEELSKIL 77
Cdd:pfam05335  61 VEQLEQELREAEAVVQEESASLQQSQANANAAQRAAQQAQQQLEALTAAL 110

OCRE domain found in angiogenic factor VG5Q and similar proteins; VG5Q, also called angiogenic factor with G patch and FHA domains 1 (AGGF1), or G patch domain-containing protein 7, or vasculogenesis gene on 5q protein, functions as a potent angiogenic factor in promoting angiogenesis through interacting with TWEAK (also known as TNFSF12), which is a member of the tumor necrosis factor (TNF) superfamily that induces angiogenesis in vivo. VG5Q can bind to the surface of endothelial cells and promote cell proliferation, suggesting that it may act in an autocrine fashion. The chromosomal translocation t(5;11) and the E133K variant in VG5Q are associated with Klippel-Trenaunay syndrome (KTS), a disorder characterized by diverse effects in the vascular system. In addition to a forkhead-associated (FHA) domain and a G-patch motif, VG5Q contains an N-terminal OCtamer REpeat (OCRE) domain that is characterized by a 5-fold, imperfectly repeated octameric sequence.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1016683080 199 AAVSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 252
Cdd:cd16164     1 AAVSQSGFVYDEATGMYYDPSTGYYYDSETQLYYDPNTGTYYYYDEESGSYQFH 54

OCRE domain; The OCtamer REpeat (OCRE) has been annotated as a 42-residue sequence motif with 12 tyrosine residues in the spliceosome trans-regulatory elements RBM5 and RBM10 (RBM [RNA-binding motif]), which are known to regulate alternative splicing of Fas and Bcl-x pre-mRNA transcripts. The structure of the domain consists of an anti-parallel arrangement of six beta strands.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1016683080 202 SQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 252
Cdd:pfam17780   1 DSSGYVYDEASGYYYDPTTGYYYDPNTGLYYDPATGKYYTYDEETKSYVPH 51

OCRE domain; The OCRE (OCtamer REpeat) domain contains 5 repeats of an 8-residue motif, which were shown to form beta-strands. Based on the architectures of proteins containing OCRE domains, a role in RNA metabolism and/or signalling has been proposed.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1016683080 201 VSQTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRYQFH 252
Cdd:cd16074     3 PDPSGFVFDPNSGYYYDPSTGLYYDPNTGYYYDPTSGTYYIWDDELGAYVPV 54

FHA domain; The FHA (Forkhead-associated) domain is a phosphopeptide binding motif.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1016683080 434 TIGREKDmeHTLRIPEVGVSKFHAEIYFDhDLQSYVLVDQGSQNGTVVNGKQILQpktkcDPYVLEHGDEVKI 506
Cdd:pfam00498   2 TIGRSPD--CDIVLDDPSVSRRHAEIRYD-GGGRFYLEDLGSTNGTFVNGQRLGP-----EPVRLKDGDVIRL 66

forkhead associated (FHA) domain found in Sulfolobus Acidocaldarius FHA domain-containing protein ArnA and similar proteins; ArnA is an FHA domain-containing protein from Sulfolobus acidocaldarius that was shown to strongly interact with ArnB, a von Willebrand domain-containing protein. They act synergistically and negatively to modulate motility. ArnA is involved in regulating archaella expression in S. acidocaldarius. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 411 VIVIRSPVLQTGSLFIITaVNPATIGRekDMEHTLRIPEVGVSKFHAEIYFDHdlQSYVLVDQGSQNGTVVNGKQILQPK 490
Cdd:cd22680     2 VLEILSSPNLTGKKFPFD-FSSVSIGR--DPENVIVIPDPFVSRNHARITVDS--NEIYIEDLGSTNGTFVNDFKRIKGP 76

                          90       100
                  ....*....|....*....|....
gi 1016683080 491 TKcdpyvLEHGDEVKIGE-TVLSF 513
Cdd:cd22680    77 AK-----LHPNDIIKLGRtTVLKV 95

forkhead associated (FHA) domain found in Bdellovibrio bacteriovorus GGDEF domain protein DgcB and similar proteins; DgcB is a GGDEF enzyme that produces cyclic-di-GMP in response to an unknown stimulus. It appends the C-terminal GGDEF enzymatic domain with an N-terminal forkhead-associated (FHA) domain that acts as a consensus phosphopeptide sensor. The GGDEF and sensory FHA domains form an asymmetrical dimer.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 411 VIVIRSPVLQTGSLFIITAvNPATIGRekDMEHTLRIPEVGVSKFHAEIYFDHDLQSyvLVDQGSQNGTVVNGKQIlqpk 490
Cdd:cd22682     1 ALLMIIGPPGVGKQFPITE-STIVIGR--SVESQVQIDDDSVSRYHAKLAVNPSAVS--IIDLGSTNGTIVNGKKI---- 71

                          90       100
                  ....*....|....*....|....*
gi 1016683080 491 TKCDPYVLEHGDEVKIGETVLSFHI 515
Cdd:cd22682    72 PKLASCDLQNGDQIKIGNTIFKFHE 96

forkhead associated (FHA) domain found in proliferation marker protein Ki-67 and similar proteins; Ki-67, also called antigen identified by monoclonal antibody Ki-67, antigen KI-67, or antigen Ki67, acts as a biological surfactant to disperse mitotic chromosomes. It is required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly. Ki-67 binds DNA with a preference for supercoiled DNA and AT-rich DNA. It may also play a role in chromatin organization. Ki-67 contains an FHA domain at its N-terminus. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 410 RVIVIRSPVlQTGSLFIITAvNPATIGRekDMEHTLRIPEVGVSKFHAEIYFDHDLQSYvLVDQGSQNGTVVNGKQILQP 489
Cdd:cd22673     2 KLVVIKKDG-TDGSRFPLTK-KSCTFGR--DLSCDIRIQLPGVSREHCRIEVDENGKAY-LENLSTTNPTLVNGKAIEKS 76

                          90       100
                  ....*....|....*....|....*
gi 1016683080 490 KTkcdpyvLEHGDEVKIGETVLSFH 514
Cdd:cd22673    77 AE------LKDGDVITIGGRSFRFE 95

forkhead associated (FHA) domain found in Myxococcus xanthus EspA and similar proteins; EspA is a histidine protein kinase with a fork head-associated (FHA) domain at the N-terminus and a receiver domain at the C-terminus. It functions as an inhibitor of sporulation during early fruiting body development while cells are aggregating into raised mounds. EspA is part of a two-component signal transduction system that regulates the timing of sporulation initiation. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 434 TIGREKDMehTLRIPEVGVSKFHAEIYFDHDlqSYVLVDQGSQNGTVVNGKQILQPKtkcdpyvLEHGDEVKIGETVLSF 513
Cdd:cd22698    24 TIGRSSNN--DIRLNDHSVSRHHARIVRQGD--KCNLTDLGSTNGTFLNGIRVGTHE-------LKHGDRIQLGETIFRF 92

forkhead associated (FHA) domain found in Mycobacterium tuberculosis GarA, Corynebacterium glutamicum OdhI and similar proteins; This family includes Mycobacterium tuberculosis glycogen accumulation regulator GarA and Corynebacterium glutamicum oxoglutarate dehydrogenase inhibitor (OdhI). GarA is involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent molecular switch that modulates the activities of Kgd, Gdh and GltB. GarA binds to Kgd, Gdh, GltB, PknB, and the N-terminal region of PknG via its FHA domain. OdhI is an essential component of the PknG signaling pathway. It can inhibit the activity of 2-oxoglutarate dehydrogenase only when it is unphosphorylated. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 411 VIVIRSPvlQTGSLFIITAvNPATIGREKDMEHTLriPEVGVSKFHAEiyFDHDLQSYVLVDQGSQNGTVVNGKQIlqpk 490
Cdd:cd22684     4 LVVRRGP--NAGARFLLDQ-DVTTAGRHPESDIFL--DDVTVSRRHAE--FRRAEGGFVVRDVGSLNGTYVNRERI---- 72

                          90       100
                  ....*....|....*....|....
gi 1016683080 491 tkcDPYVLEHGDEVKIGETVLSFH 514
Cdd:cd22684    73 ---DSAVLRNGDEVQIGKFRLVFF 93

OCRE domain found in RNA-binding protein 5 (RBM5) and similar proteins; RBM5 is also called protein G15, H37, putative tumor suppressor LUCA15, or renal carcinoma antigen NY-REN-9. It is a known modulator of apoptosis. It acts as a tumor suppressor or an RNA splicing factor. RBM5 shows high sequence similarity to RNA-binding protein 6 (RBM6 or NY-LU-12 or g16 or DEF-3). Both of them specifically binds poly(G) RNA. RBM5 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1016683080 206 FSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRY 249
Cdd:cd16168     8 YQYDESSGYYYDPITGLYYDPNSQYYYNSLTQQYLYWDGEKQTY 51

OCRE domain found in RNA-binding protein 6 (RBM6) and similar proteins; RBM6, also called lung cancer antigen NY-LU-12, or protein G16, or RNA-binding protein DEF-3, has been predicted to be a nuclear factor based on its nuclear localization signal. It shows high sequence similarity to RNA-binding protein 5 (RBM5 or LUCA15 or NY-REN-9). Both specifically binds poly(G) RNA. RBM6 contain two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, a nuclear localization signal, and a G-patch/D111 domain. In contrast to RBM5, RBM6 has an additional unique domain, the POZ (poxvirus and zinc finger) domain, which may be involved in protein-protein interactions and inhibit binding of target sequences by zinc fingers.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1016683080 185 EGSSLAESLRAAAEaavsqTGFSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYY 241
Cdd:cd16163     1 EGSGPAPTYRSDPD-----SGYIYDPETGYYYDPVTGLYYDPATGEYVDPDTGTLPY 52

OCRE domain found in RNA-binding protein 10 (RBM10) and similar proteins; RBM10, also called G patch domain-containing protein 9, or RNA-binding protein S1-1 (S1-1), is a paralogue of putative tumor suppressor RNA-binding protein 5 (RBM5 or LUCA15 or H37). It may play an important role in mRNA generation, processing and degradation in several cell types. The rat homolog of human RBM10 is protein S1-1, a hypothetical RNA binding protein with poly(G) and poly(U) binding capabilities. RBM10 contains two N-terminal RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), an OCtamer REpeat (OCRE) domain, two C2H2-type zinc fingers, and a G-patch/D111 domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1016683080 206 FSYDENTGLYFDHSTGFYYDSENQLYYDPSTGIYYYCDVESGRY 249
Cdd:cd16167     9 YQYDETSGYYYDPQTGLYYDPNSQYYYNAQTQQYLYWDGERRTY 52

forkhead associated (FHA) domain found in the centrosomal protein of 170 kDa protein (Cep170) family; The Cep170 family includes Cep170 and Cep170B. Cep170, also called Cep170A, KARP-1-binding protein, or KARP1-binding protein, is a protein that localizes to centrosomes as well as spindle microtubules and plays a role in microtubule organization and microtubule assembly. It is required for centriole subdistal appendage assembly. Cep170 is phosphorylated during M phase and interacts with Polo-like kinase 1 (Plk1). Cep170B, also called centrosomal protein 170B, plays a role in microtubule organization. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 435 IGREkdmEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTVVNGKQILQpktkcDPYV-LEHGDEVKIGETVLSF 513
Cdd:cd22704    21 VGRE---DCDLILQSRSVDKQHAVITYDQIDNEFKIKDLGSLNGTFVNDSRIPE-----QTYItLKLGDSIRFGYDTNVY 92

                  ....*...
gi 1016683080 514 HIHPGSDT 521
Cdd:cd22704    93 RFEQLSLT 100

forkhead associated (FHA) domain found in Saccharomyces cerevisiae fork head protein homolog 1 (FKH1), 2 (FKH2) and similar proteins; This family includes FKH1 and FKH2, as well as pre-rRNA-processing protein FHL1. FKH1 and FKH2 are forkhead transcription factors that regulate the expression of the CLB2 cluster of genes during the G2/M phase of the mitotic cell cycle. The CLB2 cluster of genes includes mitotic regulators such as CLB1, CLB2, CDC5 and CDC20, as well as SWI5 and ACE2. FKH1 and FKH2 are involved in HMRa silencing. They associate with the coding regions of active genes and influence, in opposing ways, transcriptional elongation and termination, and coordinate early transcription elongation and pre-mRNA processing. Both FKH1 and FKH2 play a role as regulators of lifespan in collaboration with the anaphase-promoting complex (APC), likely through combined regulation of stress response, genomic stability, and cell cycle regulation. They also function in controlling yeast cell morphology by preventing pseudohyphal growth and act as rate-limiting replication origin activators via their interaction with the origin recognition complex (ORC). FHL1 is a forkhead protein that controls the pre-rRNA processing machinery in conjunction with IFH1. It might act as a transcriptional regulator of genes specifically involved in that process. IFH1 convert FHL1 from a repressor to an activator. This family also includes AtFHA1 and AtFHA2, which may play a role in the control of plant organ development. AtFHA2 is specifically involved in the regulation of stamen development. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 432 PATIGRE------KDMEHT---LRIPEVgVSKFHAEIYFDHDLQSYVLVDQGSqNGTVVNGkqilQPKTKCDPYV-LEHG 501
Cdd:cd22701    18 EVVLGRNsknsssTAADSVdidLGPSKK-ISRRHARIFYDFTTQCFELSVLGR-NGVKVDG----ILVKPGSPPVpLRSG 91

                          90
                  ....*....|..
gi 1016683080 502 DEVKIGETVLSF 513
Cdd:cd22701    92 SLIQIGGVLFYF 103

second forkhead associated (FHA) domain found in Saccharomyces cerevisiae Serine/threonine-protein kinase RAD53 and similar proteins; RAD53, also called CHEK2 homolog, or serine-protein kinase 1 (Spk1), is a nuclear protein kinase that phosphorylates proteins on serine, threonine, and tyrosine. It controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints and prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5. It may be involved in the phosphorylation of RPH1. RAD53 contains two FHA domains. This model corresponds to the second one. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 423 SLFIITavNPATIGREKDMEHTLRipEVGVSKFHAEIYFDHDLQS--YVLVDQGSQNGTVVNGKQILQPKTkcdpYVLEH 500
Cdd:cd22690    13 DIELTQ--NTTFIGRSKDCDEEIT--DPRISKHHCIITRKRSGKGldDVYVTDTSTNGTFINNNRLGKGSQ----SLLQD 84

                  ....*.
gi 1016683080 501 GDEVKI 506
Cdd:cd22690    85 GDEIVL 90

OCRE domain found in Zinc-finger and OCRE domain-containing Protein 1 (ZOP1) and similar proteins found in plant; ZOP1 is a novel plant-specific nucleic acid-binding protein required for both RNA-directed DNA methylation (RdDM) and pre-mRNA splicing. It promotes RNA polymerase IV (Pol IV)-dependent siRNA accumulation, DNA methylation, and transcriptional silencing. As a pre-mRNA splicing factor, ZOP1 associates with several typical splicing proteins as well as with RNA polymerase II (RNAP II and Pol II). It also shows both RdDM-dependent and -independent roles in transcriptional silencing. ZOP1 contains an N-terminal C2H2-type ZnF domain and an OCtamer REpeat (OCRE) domain that is usually related to RNA processing.

                          10        20
                  ....*....|....*....|....*...
gi 1016683080 216 FDHSTGFYYDSENQLYYDPSTGIYYYCD 243
Cdd:cd16165    10 LDSKSGYYYNAATRYYYDPKTGMYYSDE 37

forkhead associated (FHA) domain found in Saccharomyces cerevisiae meiosis-specific serine/threonine-protein kinase MEK1 and similar proteins; MEK1 (EC 2.7.11.1), also known as MRE4, is a meiosis-specific protein kinase required for chromosome synapsis and meiotic recombination. The recruitment and activation of MEK1 require the phosphorylation of the chromosome axis protein Hop1 at Thr318 (pT318), which is necessary for recognition by the MEK1 FHA domain. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1016683080 427 ITAVNPATIGRekDMEHTLRIPEVGVSKFHAEIY---FDHDLQSYVLVDQGSQNGTVVNGKQIlqpkTKCDPYVLEHGD 502
Cdd:cd22670    18 IYKNQVITIGR--SPSCDIVINDPFVSRTHCRIYsvqFDESSAPLVYVEDLSSNGTYLNGKLI----GRNNTVLLSDGD 90

forkhead associated (FHA) domain found in Mycobacterium tuberculosis glycogen accumulation regulator GarA and similar proteins; GarA is an FHA domain-containing protein involved in the regulation of glutamate metabolism. It acts as a phosphorylation-dependent ON/OFF molecular switch that modulates the activities of KGD, GDH and GltB. Its FHA domain has dual specificity. It binds to both phosphorylated upstream partners, such as the kinases PknB and PknG, and nonphosphorylated downstream partners, such as the 2-oxoglutarate decarboxylase KGD. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 406 PPCIRVIVI-RSPvlQTGSLFIITAVNpATIGREKDMEhtLRIPEVGVSKFHAEiyFDHDLQSYVLVDQGSQNGTVVNGK 484
Cdd:cd22720     1 PPGSALLVVkRGP--NAGSRFLLDQAI-TSAGRHPDSD--IFLDDVTVSRRHAE--FRLENNEFNVVDVGSLNGTYVNRE 73

                          90       100
                  ....*....|....*....|....*....
gi 1016683080 485 QIlqpktkcDPYVLEHGDEVKIGETVLSF 513
Cdd:cd22720    74 PV-------DSAVLANGDEVQIGKFRLVF 95

forkhead associated (FHA) domain found in Synechocystis sp. Slr1951 protein and similar proteins; This subfamily corresponds to a group of uncharacterized FHA domain-containing proteins which show high sequence similarity with Synechocystis sp. protein Slr1951 and protein Sll1895. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 434 TIGREKdmEHTLRIPEVGVSKFHA----EIYFDHDLQSYVLVD----QGSQNGTVVNGKQILQpktkcdpYVLEHGDEVK 505
Cdd:cd22697    21 TIGRHP--GNDIQIPSQQISRRHAtlrrKINPNLDISFWIIDGdlegAESLNGLWVNGERILQ-------HELVNGDEIA 91

                  ....*
gi 1016683080 506 IGETV 510
Cdd:cd22697    92 LGPKI 96

OCRE domain found in Zinc-finger and OCRE domain-containing Protein 1 (ZOP1) and similar proteins found in plant; ZOP1 is a novel plant-specific nucleic acid-binding protein required for both RNA-directed DNA methylation (RdDM) and pre-mRNA splicing. It promotes RNA polymerase IV (Pol IV)-dependent siRNA accumulation, DNA methylation, and transcriptional silencing. As a pre-mRNA splicing factor, ZOP1 associates with several typical splicing proteins as well as with RNA polymerase II (RNAP II and Pol II). It also shows both RdDM-dependent and -independent roles in transcriptional silencing. ZOP1 contains an N-terminal C2H2-type ZnF domain and an OCtamer REpeat (OCRE) domain that is usually related to RNA processing.

                          10        20        30
                  ....*....|....*....|....*....|
gi 1016683080 208 YDENTGLYFDHSTGFYYDSENQLYYDPSTG 237
Cdd:cd16165    10 LDSKSGYYYNAATRYYYDPKTGMYYSDETG 39

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1016683080 619 SNKGRKMLEKMGWKKGEGLGKDGGGMKTPIQLQLRRTHAGLG 660
Cdd:pfam01585   2 SNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLG 43

forkhead associated (FHA) domain found in forkhead-associated domain-containing protein 1 (FHAD1) and similar proteins; FHAD1, also called FHA domain-containing protein 1, is an uncharacterized FHA domain-containing protein. The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1016683080 434 TIGREkdmEHTLRIPEVGVSKFHAEIYFDHDLQSYVLVDQGSQNGTVVNGKQI 486
Cdd:cd22700    19 TIGRE---GCDLVLQSPGVEEQHAVIEYSEQENCFVLQDLNTAQGTYVNDCRI 68

second forkhead associated (FHA) domain found in Mycobacterium tuberculosis ABC transporter ATP-binding/permease protein Rv1747 and similar proteins; Rv1747 is a putative ATP-binding cassette (ABC) transporter involved in the translocation of an unknown substrate across the membrane. It is required for normal virulent infection by M. tuberculosis. Rv1747 has a cytoplasmic regulatory module consisting of two pThr-interacting forkhead-associated (FHA) domains connected by a conformationally disordered linker with two phospho-acceptor threonines (pThr). Recruitment and phosphorylation of Rv1747 depend on the interaction between its two non-redundant FHA domains and the autophosphorylated form of serine/threonine protein kinase PknF. This model corresponds to the second FHA domain, which has a circularly permuted FHA domain fold with a conserved pThr-binding interface.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 433 ATIGREKDmeHTLRIPEVGVSKFHAEIYFDHDlqSYVLVDQGSQNGTVVNGKQIlqpktkcDPYVLEHGDEVKIGETVLS 512
Cdd:cd22737    23 VRIGRASD--NDIVIPEGSVSRHHATLVPTPG--GTQIRDLRSTNGTFVNGLRV-------DAALLHDGDVVTIGDIDFV 91

                  .
gi 1016683080 513 F 513
Cdd:cd22737    92 F 92

forkhead associated (FHA) domain found in RING finger protein 8 (RNF8) and similar proteins; RNF8 is a telomere-associated E3 ubiquitin-protein ligase that plays an important role in DNA double-strand break (DSB) repair via histone ubiquitination. It is localized in the nucleus and interacts with class III E2s (UBE2E2, UbcH6, and UBE2E3), but not with other E2s (UbcH5, UbcH7, UbcH10, hCdc34, and hBendless). It recruits UBC13 for lysine 63-based self polyubiquitylation. Its deficiency causes neuronal pathology and cognitive decline, and its loss results in neuron degeneration. RNF8, together with RNF168, catalyzes a series of ubiquitylation events on substrates such as H2A and H2AX, with the H2AK13/15 ubiquitylation being particularly important for recruitment of repair factors p53-binding protein 1 (53BP1) or the RAP80-BRCA1 complex to sites of DSBs. Specially, RNF8 mediates the ubiquitination of gammaH2AX, and recruits 53BP1 and BRCA1 to DNA damage sites which promotes DNA damage response (DDR) and inhibits chromosomal instability. Moreover, RNF8 interacts with retinoid X receptor alpha (RXR alpha) and enhances its transcription-stimulating activity. It also regulates the rate of exit from mitosis and cytokinesis. RNF8 contains an N-terminal FHA domain, which is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1016683080 434 TIGREKDMEHTLRIPE-VGVSKFHAEIYFDhDLQSYVLVDQGSQNGTVVNGKQIlqPKTKcdPYVLEHGDEVKIG 507
Cdd:cd22663    24 TVGRGLGVTYQLVSTCpLMISRNHCVLKKN-DEGQWTIKDNKSLNGVWVNGERI--EPLK--PYPLNEGDLIQLG 93

forkhead associated (FHA) domain found in chloroplastic zeaxanthin epoxidase (ZEP) and similar proteins; ZEP, also called protein ABA DEFICIENT 1, ABA1, protein IMPAIRED IN BABA-INDUCED STERILITY 3, protein LOW EXPRESSION OF OSMOTIC STRESS-RESPONSIVE GENES 6, or protein NON-PHOTOCHEMICAL QUENCHING 2, plays an important role in the xanthophyll cycle and abscisic acid (ABA) biosynthesis. It converts zeaxanthin into antheraxanthin and subsequently violaxanthin. ZEP is required for resistance to osmotic and drought stresses, ABA-dependent stomatal closure, seed development and dormancy, modulation of defense gene expression, and disease resistance and non-photochemical quencing (NPQ). The FHA domain is a small phosphopeptide recognition module.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1016683080 431 NPATIGREKD---MEHTLRIPEVGVSKFHAEIYFDHDlqSYVLVDQGSQNGTVVNGKQI-LQPKTKCDPYVLEHGDEVKI 506
Cdd:cd22702    32 QPCIIGSDPHqaiSGISVVIPSPQVSELHARITCKNG--AFFLTDLGSEHGTWINDNEGrRYRAPPNFPVRLHPSDVIEF 109

                          90
                  ....*....|..
gi 1016683080 507 GETV-LSFHIHP 517
Cdd:cd22702   110 GSDKkARFRVKV 121

Protein of unknown function (DUF745); This family consists of several uncharacterized Drosophila melanogaster proteins of unknown function.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1016683080  28 VEKLERELRSCKRQVREIEKLLHHTERLYQSAESNNRELRTQVEELSKIL 77
Cdd:pfam05335  61 VEQLEQELREAEAVVQEESASLQQSQANANAAQRAAQQAQQQLEALTAAL 110