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Conserved domains on  [gi|982939717|ref|XP_015329086|]
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alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3-N-acetyl-galactosaminide alpha-2,6-sialyltransferase isoform X5 [Bos taurus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 126-302 1.03e-122

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23977:

Pssm-ID: 480271  Cd Length: 228  Bit Score: 351.09  E-value: 1.03e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARDTLYVVWG 205
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 QGKHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170
                 ....*....|....*..
gi 982939717 286 MVSDSYCSQESRCHHPH 302
Cdd:cd23977  161 MVSDSYCRNKNHSSVPY 177
 
Name Accession Description Interval E-value
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 126-302 1.03e-122

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 351.09  E-value: 1.03e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARDTLYVVWG 205
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 QGKHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170
                 ....*....|....*..
gi 982939717 286 MVSDSYCSQESRCHHPH 302
Cdd:cd23977  161 MVSDSYCRNKNHSSVPY 177
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 112-285 2.53e-27

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 107.31  E-value: 2.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717  112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSH 191
Cdd:pfam00777  29 LELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNLG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717  192 YFQ-QARDTLYV---------VWGQG--KHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKN-RR 258
Cdd:pfam00777 109 FSHpRDPFVEFVlvpfkgrdlLWLPAflTKGNVSRSLRVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLKgRR 188

                         170       180
                  ....*....|....*....|....*..
gi 982939717  259 qsgsfLSTGWFTMILALELCEEIVVYG 285
Cdd:pfam00777 189 -----PSTGLLMLSLALHLCDEVSLYG 210
 
Name Accession Description Interval E-value
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 126-302 1.03e-122

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 351.09  E-value: 1.03e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARDTLYVVWG 205
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 QGKHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23977   81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170
                 ....*....|....*..
gi 982939717 286 MVSDSYCSQESRCHHPH 302
Cdd:cd23977  161 MVSDSYCRNKNHSSVPY 177
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 126-302 1.82e-96

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 284.14  E-value: 1.82e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRN-YSHYFQQARDTLYVVW 204
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNaILLLAGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 205 GQGKHMDRALGGRtYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVY 284
Cdd:cd23965   81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                        170
                 ....*....|....*...
gi 982939717 285 GMVSDSYCSqesrcHHPH 302
Cdd:cd23965  160 GMVPENYCR-----EHPN 172
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 126-295 1.50e-76

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 233.67  E-value: 1.50e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARDTLYVVWG 205
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 QGKHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23975   81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                        170
                 ....*....|
gi 982939717 286 MVSDSYCSQE 295
Cdd:cd23975  161 MINDTYCKTE 170
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 111-301 2.52e-65

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 205.49  E-value: 2.52e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 111 GYSSVPDGKPLvRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYS 190
Cdd:cd23976    1 GYISIIDHKPL-KMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 191 HYFQQARDTLYVVWGQGKHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFT 270
Cdd:cd23976   80 ELLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFT 159

                        170       180       190
                 ....*....|....*....|....*....|.
gi 982939717 271 MILALELCEEIVVYGMVSDSYCSQEsrcHHP 301
Cdd:cd23976  160 MIIALELCDRINVYGMVPPDFCRDP---NHP 187
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 126-297 1.62e-62

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 197.77  E-value: 1.62e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARDTLYVVWG 205
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 QGKHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23978   81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170
                 ....*....|..
gi 982939717 286 MVSDSYCSQESR 297
Cdd:cd23978  161 MVPPNYCSKRPT 172
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 129-299 1.20e-39

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 137.88  E-value: 1.20e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 129 CAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQ--QARDTLYVVWGQ 206
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHplPLEEEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 207 GKHmdralggRTYRALLQLTRMYPGLQVY--TFTERMMAYCDQVFQDETGKNrRQSGSFLSTGWFTMILALELCEEIVVY 284
Cdd:cd19952   81 AAA-------ADFKRLKRRKKRHDNAVLLltDPAPDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDLY 152

                        170
                 ....*....|....*
gi 982939717 285 GMVSDSYCSQESRCH 299
Cdd:cd19952  153 GFGVDSGHAPKVPYH 167
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 112-285 2.53e-27

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 107.31  E-value: 2.53e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717  112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSH 191
Cdd:pfam00777  29 LELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNLG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717  192 YFQ-QARDTLYV---------VWGQG--KHMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKN-RR 258
Cdd:pfam00777 109 FSHpRDPFVEFVlvpfkgrdlLWLPAflTKGNVSRSLRVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLKgRR 188

                         170       180
                  ....*....|....*....|....*..
gi 982939717  259 qsgsfLSTGWFTMILALELCEEIVVYG 285
Cdd:pfam00777 189 -----PSTGLLMLSLALHLCDEVSLYG 210
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 127-299 1.06e-25

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 103.12  E-value: 1.06e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 127 RSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTsvpLLLRNYSHYFqqaRDTLY----- 201
Cdd:cd23968   46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ---ILSKPEFNFL---TDPLYrnvtl 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 202 VVWGQGK------HMDRALGGRTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETgKNRRQSGSfLSTGWFTMILAL 275
Cdd:cd23968  120 LVWDPSSynvnleKWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPRFLWRLWDILQEYT-PEKIKPNP-PSSGFIGIVLML 197

                        170       180
                 ....*....|....*....|....
gi 982939717 276 ELCEEIVVYGMVSDSycSQESRCH 299
Cdd:cd23968  198 HLCDWVDVYEYVPSV--RQTDRCH 219
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 120-285 4.01e-22

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 93.48  E-value: 4.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 120 PLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLrvishTSV-PLLLRNYSHYFQQARD 198
Cdd:cd23963   57 PFSHKRYKTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNL-----TTLnPSILKRRYNSLKKNRD 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 199 TL-----------YVVWGqGKHMDRALGGRTYRALLQLTRMYPGLQvytftermMAYCDQVFQDETGK--NRRQSGSFLS 265
Cdd:cd23963  132 RDkflnrlkeyngSILWY-PKFSFKSSTNLLLKAARALKKNGLNLT--------VVYSNPEHFLAVQKfwKRRGLEKRPS 202

                        170       180
                 ....*....|....*....|
gi 982939717 266 TGWFTMILALELCEEIVVYG 285
Cdd:cd23963  203 TGLYLVSLALTFCDEIHLYG 222
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 127-300 5.99e-22

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 92.98  E-value: 5.99e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 127 RSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTsvplLLRNYSHYFQQA---RDTLYVV 203
Cdd:cd23986   50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQ----ILTNPNHHFIDSslyKDVILVA 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 204 WGQG----------KHMDRALggrtYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSflSTGWFTMIL 273
Cdd:cd23986  126 WDPApysanlhkwyKKPDYNL----FTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP--SSGFIGILI 199

                        170       180
                 ....*....|....*....|....*..
gi 982939717 274 ALELCEEIVVYGMVSdSYcSQESRCHH 300
Cdd:cd23986  200 MMSMCREVHVYEYIP-SV-RQTDLCHY 224
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 103-291 3.20e-20

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 88.49  E-value: 3.20e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 103 VPGPLHFSgySSVPDGkplvrelCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSV 182
Cdd:cd23966   63 VPGENPYR--TRDPNR-------CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 183 pLLLRNYSHY----FQqardTLYVVWgqgkhMDRALGG----RTY---RALLQLTRmyPGLQVY--TFtermMAYcdqVF 249
Cdd:cd23966  134 -VDLDPGVHLvlvpFK----VLDLQW-----LISALTTgeitRTYtpvKRFIKADK--DKVLVInpAF----IKY---VH 194

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 982939717 250 QDETGKNrrqsGSFLSTGWFTMILALELCEEIVVYGMVSDSY 291
Cdd:cd23966  195 DNWTEHH----GRYPSTGFLALIFALHICDEVSVFGFGADSK 232
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 126-290 2.83e-19

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 85.69  E-value: 2.83e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARdTLYVVWg 205
Cdd:cd23979   80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFK-TLDLLW- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 qgkhMDRALG-GR---TYRALLQLTRMYpglqvytfTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEI 281
Cdd:cd23979  158 ----ITSALStGQirfTYAPVKQFLRVD--------KDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVCDEV 225


                 ....*....
gi 982939717 282 VVYGMVSDS 290
Cdd:cd23979  226 NVYGFGADS 234
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 127-305 1.66e-18

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 83.22  E-value: 1.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 127 RSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTsvplLLRNYSHYFqqARDTLY----- 201
Cdd:cd23985   46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKF--LKDSLYnegil 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 202 VVWGQG----------KHMDRAL--GGRTYRallqltRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRQSGSflSTGWF 269
Cdd:cd23985  120 IVWDPApyhsdipewyKNPDYNFfeNYKTYR------RLNPNQPFYILHPQMQWELWDIIQENSPEEIQPNPP--SSGML 191

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 982939717 270 TMILALELCEEIVVYGMVSDSycSQESRCH-HPHFTD 305
Cdd:cd23985  192 GIILMMTLCDQVDVYEFLPSK--RKTDVCHyYQKFFD 226
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 97-291 1.33e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 81.72  E-value: 1.33e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717  97 IKSRPTVPGPLHFSGYSSVPDGkplvrelCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRV 176
Cdd:cd23973   61 VELIPKPKEQQLLALSPPGGDG-------CIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYV 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 177 ISHTSVPLLLRNYSHY-FQQA---RDTLYVVWGQGKhmdralggRTY---RALLQ--------LTRMYPglQVY---TFT 238
Cdd:cd23973  134 HTAHSITSSLMILQKRgFKNIpqdKDIKYILFPEGP--------RDYqwlEALLKnktipsgaYYGRRP--RSYfsgDFT 203

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982939717 239 ERMMAYCDQVFQDETgKNRRQSGSFL----------STGWFTMILALELCEEIVVYGMVSDSY 291
Cdd:cd23973  204 EDKYLVLHPDFLRYV-KNRFLRSKTLkgkywaiyrpTTGAFLLLTALHLCDTVSAYGFITEDY 265
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 126-290 9.13e-17

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 78.77  E-value: 9.13e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHYFQQARdTLYVVWg 205
Cdd:cd23980   81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFK-TLDLEW- 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 206 qgkHMDRALGGRTYRALLQLTRmypglQVYTFTERMMAYCDQVFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23980  159 ---VISATTTGTISHTYVPVPR-----KIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYG 230


                 ....*
gi 982939717 286 MVSDS 290
Cdd:cd23980  231 FGADS 235
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 112-285 2.21e-15

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 74.74  E-value: 2.21e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRvishTSVPLLLRNYSH 191
Cdd:cd23970   54 RSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSILEKYYN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 192 YFQQARDTL-----------YVVWGQG-KHMDRALGGRTYRALLQLTRMYPGLQVyTFTERMMAYCDQVFQDETGKNRRq 259
Cdd:cd23970  130 NLLTIQDRNnfflslkkldgAILWIPAfFFHTSATVTRTLVDFFVEHRGQLKVQL-AWPGNIMQHVNRYWKTKHLSPKR- 207

                        170       180
                 ....*....|....*....|....*.
gi 982939717 260 sgsfLSTGWFTMILALELCEEIVVYG 285
Cdd:cd23970  208 ----LSTGILMYTLASAICEEIHLYG 229
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 126-203 2.36e-15

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 73.48  E-value: 2.36e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYShyfqqaRDTLYVV 203
Cdd:cd23967    2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYD------SDWLLVL 73
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 112-286 1.58e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 72.45  E-value: 1.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRvishTSVPLLLRNYSH 191
Cdd:cd23969   50 YQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLT----TMNPSVIPHAYG 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 192 YFQQARDtlyvvwgQGKHMDR---------------ALGGRTY---------RALLQLTRMYPGLQVYTFTERMMAycdq 247
Cdd:cd23969  126 DLVNATD-------KEKFVERlrqlgdsilwipafvSKGGEEHvqwtneiilKHKLNVKTAYPPLRLNHAIRGYWL---- 194

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 982939717 248 vfQDETGKNRRQSGSFLSTgwftmiLALELCEEIVVYGM 286
Cdd:cd23969  195 --TTKFRIKRPSTGLLMYT------LATRFCDEIHLYGF 225
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 112-285 4.28e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 71.14  E-value: 4.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLL---LRN 188
Cdd:cd23988   50 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRN 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 189 YS------HYFQQARDTL-----YVVWGQGKHMDrALGGRTYRALLQLTRMYPGLQV------YTFTERMMAycdqvfqd 251
Cdd:cd23988  130 ESdrekfvHRLSMLNDSVlwipaFMVKGGEKHVE-WVNALILKNKLKVRTAYPSLRLihavrgYWLTNKVNI-------- 200

                        170       180       190
                 ....*....|....*....|....*....|....
gi 982939717 252 etgknRRQsgsflSTGWFTMILALELCEEIVVYG 285
Cdd:cd23988  201 -----KRP-----STGLLMYTLATRFCDEIHLYG 224
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 126-286 5.57e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 71.13  E-value: 5.57e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVisHTSVPLLLRNYSHYfQQARDTLYVV-- 203
Cdd:cd23964   82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYT--FFPESLHNSLLKHV-PQDKDTKYLFip 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 204 -----------WGQGKHMDRALGGRTYRallqltRMYPGLQVYTFTERM-----MAYCDQVFQDETGKNRRqsgsflSTG 267
Cdd:cd23964  159 fkirdydyldaVLSGKPVPDGCDKGKRP------PPLFGPKLNATNVRLlhpdfIRYLFNRWLNSSTSYRP------TTG 226

                        170
                 ....*....|....*....
gi 982939717 268 WFTMILALELCEEIVVYGM 286
Cdd:cd23964  227 ALMLLTALHTCDQVSVYGF 245
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 126-202 2.57e-13

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 67.84  E-value: 2.57e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYSHyfqqarDTLYV 202
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDP------TSLFV 72
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 126-175 2.63e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 67.77  E-value: 2.63e-13
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLR 175
Cdd:cd23982    2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIR 51
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 126-175 5.60e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 60.92  E-value: 5.60e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLR 175
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFR 51
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 126-205 4.08e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 58.40  E-value: 4.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNYShyfqqaRDTLYVVWG 205
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYE------KDSLFVLAG 75
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 112-285 6.10e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 58.81  E-value: 6.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPtVGFEADVGQRSTLRVIShtsvPLLLRNYSH 191
Cdd:cd23971   50 FSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLVTAN----PSILREKFH 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 192 YFQQARDTLY---VVWGQGKHMDRALGGRT-----YRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRqsgsf 263
Cdd:cd23971  125 NLKKRRRPFVermKVYGNALLLLPAFSYTSntepsLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARR----- 199

                        170       180
                 ....*....|....*....|..
gi 982939717 264 LSTGWFTMILALELCEEIVVYG 285
Cdd:cd23971  200 LSTGLMLVSAALELCENVHLYG 221
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 126-189 9.63e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 58.61  E-value: 9.63e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTLRVISHTSVPLLLRNY 189
Cdd:cd23974   84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAY 147
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 112-308 1.38e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 57.92  E-value: 1.38e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 112 YSSVPDGKPLVRELcRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAP-TVGFEADVGQRSTLRvishTSVPLLLRNys 190
Cdd:cd23989   50 YSLFPQDTPLQLPL-KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLV----TANPSIIDK-- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 191 hYFQQardtlyVVWGQGKHMDR-ALGGRTY---RALLQLTRMYPGLQVY-----TFTERMMAYCDQVFQDETG---KNRR 258
Cdd:cd23989  123 -RFQN------LLWSRKSFVESmKVYGRSYiymPAFSMKTGTDPSLRVYytladVGANQTVLFANPNFLRNVGkfwKSKG 195

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 982939717 259 QSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCSQESRCHHpHFTDGLL 308
Cdd:cd23989  196 VHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISH-HYYDNVL 244
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 112-174 5.37e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 56.10  E-value: 5.37e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982939717 112 YSSVPDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRSTL 174
Cdd:cd23987   50 YELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL 112
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 116-285 4.31e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 53.22  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 116 PDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVG-FEADVGQRSTL-----RVISHTSVPL----- 184
Cdd:cd23991   54 PKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLvtanpSIISIKYAKLnerrk 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 185 -LLRNYSHYfqqaRDTLYVVWGQGKHMDRALggrTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRqsgsf 263
Cdd:cd23991  134 pFLETVSVY----GDAFLLLPAFSYRSNTAL---SFKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYR----- 201

                        170       180
                 ....*....|....*....|..
gi 982939717 264 LSTGWFTMILALELCEEIVVYG 285
Cdd:cd23991  202 LSTGLMITSAALELCEEVKLYG 223
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 126-173 1.10e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 46.36  E-value: 1.10e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 982939717 126 CRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAPTVGFEADVGQRST 173
Cdd:cd23972   82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 116-285 5.19e-05

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 44.06  E-value: 5.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 116 PDGKPLVRELCRSCAVVSSSGQMLGSGLGAEIDSAECVLRMNQAP-TVGFEADVGQRSTLRVIShtsvPLLLRNYSHYFQ 194
Cdd:cd23990   54 PKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTIN----PSIITERFHKLE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982939717 195 QARDTLYVVWGQGKHMDRALGG--------RTYRALLQLTRMYPGLQVYTFTERMMAYCDQVFQDETGKNRRqsgsfLST 266
Cdd:cd23990  130 KWRRPFYEVLQVYENASVVLPAfyntrntdVSIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKR-----ISS 204

                        170
                 ....*....|....*....
gi 982939717 267 GWFTMILALELCEEIVVYG 285
Cdd:cd23990  205 GLMLVTAALELCEEVHLYG 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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