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Conserved domains on  [gi|966964429|ref|XP_015003537|]
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protein O-GlcNAcase isoform X1 [Macaca mulatta]

Protein Classification

protein O-GlcNAcase( domain architecture ID 10540838)

protein O-GlcNAcase (OGA) cleaves GlcNAc but not GalNAc from O-glycosylated proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
NAGidase pfam07555
beta-N-acetylglucosaminidase; This family has previously been described as a hyaluronidase. ...
253-529 4.27e-104

beta-N-acetylglucosaminidase; This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.


:

Pssm-ID: 429533  Cd Length: 293  Bit Score: 328.76  E-value: 4.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   253 CGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGL 332
Cdd:pfam07555    1 RGVIEGFYGTPWSHEDRLDLLDFYGRYKMNTYIYAPKDDPYHRSKWREPYPEEELAQLKELVEAARANKVDFVWAIHPGL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   333 DITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHnmcaadkEVFSSFAHAQVSITNEIYQYLGEP----ETFLFCPT 408
Cdd:pfam07555   81 DICYSSDADLDALIAKFEQLYDLGVRSFAVLFDDISY-------ELWGAAAEAQADLLNRVQKELVEKkpdvAPLIFCPT 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   409 EYCGTFcypnvsQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYK 488
Cdd:pfam07555  154 EYNGSW------DSPYLRTLGAKLDPDIQIMWTGDGVCSSEITVEDADRANEVIGRPPLIWDNYPVNDYAKDRLLLGPYT 227
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 966964429   489 GRSTELIPRLKGVLTNPNCEFEANYVAIHTLA--TWyksNMNG 529
Cdd:pfam07555  228 GRDPGLATHLAGIVSNPMEQAEASKVALFTVAdyAW---NPDG 267
RimI super family cl33885
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
1047-1107 2.58e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG0456:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 38.10  E-value: 2.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966964429 1047 VAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKD-VVILGRSL 1107
Cdd:COG0456    30 IGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDdALVMEKEL 91
 
Name Accession Description Interval E-value
NAGidase pfam07555
beta-N-acetylglucosaminidase; This family has previously been described as a hyaluronidase. ...
253-529 4.27e-104

beta-N-acetylglucosaminidase; This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.


Pssm-ID: 429533  Cd Length: 293  Bit Score: 328.76  E-value: 4.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   253 CGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGL 332
Cdd:pfam07555    1 RGVIEGFYGTPWSHEDRLDLLDFYGRYKMNTYIYAPKDDPYHRSKWREPYPEEELAQLKELVEAARANKVDFVWAIHPGL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   333 DITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHnmcaadkEVFSSFAHAQVSITNEIYQYLGEP----ETFLFCPT 408
Cdd:pfam07555   81 DICYSSDADLDALIAKFEQLYDLGVRSFAVLFDDISY-------ELWGAAAEAQADLLNRVQKELVEKkpdvAPLIFCPT 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   409 EYCGTFcypnvsQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYK 488
Cdd:pfam07555  154 EYNGSW------DSPYLRTLGAKLDPDIQIMWTGDGVCSSEITVEDADRANEVIGRPPLIWDNYPVNDYAKDRLLLGPYT 227
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 966964429   489 GRSTELIPRLKGVLTNPNCEFEANYVAIHTLA--TWyksNMNG 529
Cdd:pfam07555  228 GRDPGLATHLAGIVSNPMEQAEASKVALFTVAdyAW---NPDG 267
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
1047-1107 2.58e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 38.10  E-value: 2.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966964429 1047 VAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKD-VVILGRSL 1107
Cdd:COG0456    30 IGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDdALVMEKEL 91
 
Name Accession Description Interval E-value
NAGidase pfam07555
beta-N-acetylglucosaminidase; This family has previously been described as a hyaluronidase. ...
253-529 4.27e-104

beta-N-acetylglucosaminidase; This family has previously been described as a hyaluronidase. However, more recently it has been shown that this family has beta-N-acetylglucosaminidase activity.


Pssm-ID: 429533  Cd Length: 293  Bit Score: 328.76  E-value: 4.27e-104
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   253 CGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGL 332
Cdd:pfam07555    1 RGVIEGFYGTPWSHEDRLDLLDFYGRYKMNTYIYAPKDDPYHRSKWREPYPEEELAQLKELVEAARANKVDFVWAIHPGL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   333 DITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHnmcaadkEVFSSFAHAQVSITNEIYQYLGEP----ETFLFCPT 408
Cdd:pfam07555   81 DICYSSDADLDALIAKFEQLYDLGVRSFAVLFDDISY-------ELWGAAAEAQADLLNRVQKELVEKkpdvAPLIFCPT 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966964429   409 EYCGTFcypnvsQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYK 488
Cdd:pfam07555  154 EYNGSW------DSPYLRTLGAKLDPDIQIMWTGDGVCSSEITVEDADRANEVIGRPPLIWDNYPVNDYAKDRLLLGPYT 227
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 966964429   489 GRSTELIPRLKGVLTNPNCEFEANYVAIHTLA--TWyksNMNG 529
Cdd:pfam07555  228 GRDPGLATHLAGIVSNPMEQAEASKVALFTVAdyAW---NPDG 267
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
1047-1107 2.58e-03

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 38.10  E-value: 2.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 966964429 1047 VAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKD-VVILGRSL 1107
Cdd:COG0456    30 IGRALLEAALERARERGARRLRLEVREDNEAAIALYEKLGFEEVGERPNYYGDdALVMEKEL 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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