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Conserved domains on  [gi|1622963856|ref|XP_015003439|]
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protein Wnt-8b [Macaca mulatta]

Protein Classification

wnt family protein( domain architecture ID 14443640)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
127-431 0e+00

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381726  Cd Length: 305  Bit Score: 588.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 127 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 206
Cdd:cd19352     1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 207 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 286
Cdd:cd19352    81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 287 TTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEG 366
Cdd:cd19352   161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLGTEG 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 367 RECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 431
Cdd:cd19352   241 RECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
 
Name Accession Description Interval E-value
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
127-431 0e+00

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 588.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 127 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 206
Cdd:cd19352     1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 207 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 286
Cdd:cd19352    81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 287 TTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEG 366
Cdd:cd19352   161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLGTEG 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 367 RECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 431
Cdd:cd19352   241 RECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
WNT1 smart00097
found in Wnt-1;
118-430 9.33e-147

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 420.19  E-value: 9.33e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856  118 NHRSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTL 197
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856  198 TRNCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTC 277
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKREC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856  278 KCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRgaIADTFRSISTRELVHLEDSPDYCLENK 357
Cdd:smart00097 161 KCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVP--KNSTFKPPTETDLVYLESSPDFCEKNP 238
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622963856  358 TLGLLGTEGRECLRRGRALGrwerrSCRRLCGDCGLAVeeRRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:smart00097 239 KTGSLGTQGRQCNKTSKGLD-----GCDLLCCGRGYNT--RTVEVVERCNCKFHWCCYVKCKQCRETVEKHTC 304
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
139-430 1.00e-118

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 349.16  E-value: 1.00e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 217
Cdd:pfam00110  22 SVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKvLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKKRG 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 218 QLGGQGWLW-GGCSDNVGFGEAISKQFVDALE-TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQL 295
Cdd:pfam00110 102 KSSGEGGWEwGGCSDNIDYGYKFSRKFVDAREkKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKAL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 296 PEFREVGAHLKEKYHAALKVdllQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 375
Cdd:pfam00110 182 PPFREVGDRLKEKYDGAVKV---NRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSG 258
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 376 LGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:pfam00110 259 PD-----GCDLLC--CGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTC 306
 
Name Accession Description Interval E-value
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
127-431 0e+00

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 588.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 127 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 206
Cdd:cd19352     1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 207 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 286
Cdd:cd19352    81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 287 TTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEG 366
Cdd:cd19352   161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLGTEG 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 367 RECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 431
Cdd:cd19352   241 RECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
128-431 3.87e-178

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 499.81  E-value: 3.87e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 128 TGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFD 207
Cdd:cd19351     1 TGPKAYLTYSSSVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 208 NCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCT 287
Cdd:cd19351    81 NCGCDDSRNGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 288 TQTCWLQLPEFREVGAHLKEKYHAALKVDLLQ---GAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGT 364
Cdd:cd19351   161 IQTCWLQLADFREIGNYLKVKHDQALKLEMDKrrmRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGT 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622963856 365 EGRECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 431
Cdd:cd19351   241 EGRECLQSGKNLSQWERRSCRRLCTECGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYCA 307
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
128-431 7.16e-166

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 468.70  E-value: 7.16e-166
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 128 TGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALqlSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFD 207
Cdd:cd19340     1 SGPKAYLSLSDSVAAGAQLAMEECQYQFKWDRWNCPESAF--FSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 208 NCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCT 287
Cdd:cd19340    79 GCGCDDSKKGSKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 288 TQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIadTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGR 367
Cdd:cd19340   159 TQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRETNGSRAI--KLLNIKKNDLVYLEKSPNYCRANVTLGWPGTLGR 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 368 ECLRR-GRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 431
Cdd:cd19340   237 QCSRDkKESVSRWERKSCRRLCRACGLKVRKKVVEVTSSCNCKFHWCCEVKCETCVELVIEYTCV 301
WNT1 smart00097
found in Wnt-1;
118-430 9.33e-147

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 420.19  E-value: 9.33e-147
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856  118 NHRSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTL 197
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856  198 TRNCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTC 277
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKREC 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856  278 KCHGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRgaIADTFRSISTRELVHLEDSPDYCLENK 357
Cdd:smart00097 161 KCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVP--KNSTFKPPTETDLVYLESSPDFCEKNP 238
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622963856  358 TLGLLGTEGRECLRRGRALGrwerrSCRRLCGDCGLAVeeRRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:smart00097 239 KTGSLGTQGRQCNKTSKGLD-----GCDLLCCGRGYNT--RTVEVVERCNCKFHWCCYVKCKQCRETVEKHTC 304
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
138-430 1.27e-127

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 370.86  E-value: 1.27e-127
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 138 SSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 217
Cdd:cd13113     3 ESIAEGAQLALKECQRQFANRRWNCSTFNEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTRQG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 218 QLGGQGWLWGGCSDNVGFGEAISKQFVDALET--GQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQL 295
Cdd:cd13113    83 PEGQGDWTWGGCSDNIKFGIKFSRKFLDAREKkkGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWRQL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 296 PEFREVGAHLKEKYHAALKVDLlqGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 375
Cdd:cd13113   163 PSFREIGDYLKEKYDNAVKVKL--NNNGSGLRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNPTSPG 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 376 LGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd13113   241 PD-----SCELLC--CGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
139-430 1.00e-118

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 349.16  E-value: 1.00e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 217
Cdd:pfam00110  22 SVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKvLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKKRG 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 218 QLGGQGWLW-GGCSDNVGFGEAISKQFVDALE-TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQL 295
Cdd:pfam00110 102 KSSGEGGWEwGGCSDNIDYGYKFSRKFVDAREkKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKAL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 296 PEFREVGAHLKEKYHAALKVdllQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 375
Cdd:pfam00110 182 PPFREVGDRLKEKYDGAVKV---NRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSG 258
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 376 LGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:pfam00110 259 PD-----GCDLLC--CGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTC 306
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
139-430 9.03e-111

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 328.80  E-value: 9.03e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPeraLQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 217
Cdd:cd19338    30 EVAKGAKLGIRECQYQFRNRRWNCS---TSRKSFGKiLKRDTRETAFVYAITSAGVTYSVTRACSMGELLQCGCDKSKRG 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 218 QLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQ-DARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLP 296
Cdd:cd19338   107 KSTEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRsDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMP 186
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 297 EFREVGAHLKEKYHAALKVDllqgAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRAL 376
Cdd:cd19338   187 PFREVGDRLKERFDGAIKVK----GSNDGKSLIPEGKTIKPPTKEDLVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGV 262
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622963856 377 GrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19338   263 D-----GCDLLC--CGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTC 309
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
139-430 1.64e-102

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 308.11  E-value: 1.64e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPERAlQLSSHGG--LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 216
Cdd:cd19334    29 SIGEGAKLGVKECQYQFRNQRWNCSTVD-RDATVFGkvLLKGSREAAFVYAISSAGVVHAITRACSKGELLNCACDPTKR 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 217 GQLGGQGWLWG--GCSDNVGFGEAISKQFVDALETGQ-DARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 293
Cdd:cd19334   108 GKGRDSKGEFDwgGCSDNVKYGINFARKFVDARERRVrDARALMNLHNNRAGRKAVKKNLKLQCKCHGVSGSCTIRTCWR 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 294 QLPEFREVGAHLKEKYHAALKVDLLQGagnsaaGRGAIADTF--RSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLR 371
Cdd:cd19334   188 ALAEFREVGDYLREKYDGAVQVTMNQS------GTNLLAANKghKKPTRSDLVYFESSPDYCVPNPETGSLGTAGRVCNK 261
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1622963856 372 RGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19334   262 TSTGTD-----GCDIMC--CGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTC 313
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
139-430 1.01e-94

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 287.67  E-value: 1.01e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCpeRALQLSSHGG--LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 216
Cdd:cd19336    24 SVRRGAQLAIEECQFQFRNRRWNC--STLDKEPVFGkvLNQGTREAAFVHAISSAGVAHAVTRACSSGELEKCGCDRSVR 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 217 GQLGGQGWLWGgCSDNVGFGEAISKQFVDALETG----QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCW 292
Cdd:cd19336   102 GRSPEGFQWSG-CSDNVAYGVAFSKSFVDARERRkgraSSSRALMNLHNNEAGRKAIEKNMRVECKCHGVSGSCELKTCW 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 293 LQLPEFREVGAHLKEKYHAALKVDLLQgagnsAAGRGAIA---DTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGREC 369
Cdd:cd19336   181 RAMPTFREVGNILKEKFDGATEVQQKR-----IGSRPVLVpknPQFKPHTDADLVYLDSSPDFCEPDPKTGSLGTHGRVC 255
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1622963856 370 LRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19336   256 NKTSKAID-----GCDLLC--CGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTC 309
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
139-430 3.14e-93

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 284.18  E-value: 3.14e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCperalqlSSHGG-------LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 211
Cdd:cd19339    25 AIGEGAQLGIEECQFQFRNHRWNC-------TLLGErtvfgqeLPVGSREAAFTYAITSAGVAYAITQACSQGNLSDCGC 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 212 DDSRNGQLGGQGWLW-GGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQT 290
Cdd:cd19339    98 DKSKKGYGKSDEGWKwGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCHGVSGSCTTKT 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 291 CWLQLPEFREVGAHLKEKYHAALKVDLLQG--AGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRE 368
Cdd:cd19339   178 CWTTLPSFREIGDYLKKKYERARRVEPVRGrrRRRPTFLKLKISRKYKKPRPRDLVYLEKSPNYCEKDPLTGSLGTVGRR 257
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1622963856 369 CLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19339   258 CNRTSTGTD-----GCDLMC--CGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTC 312
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
139-430 9.31e-93

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 282.59  E-value: 9.31e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQ 218
Cdd:cd19344    18 SVSEGARLGIYECQHQFRHERWNCSTTNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRACSAGNLTDCSCDSRRQGQ 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 219 LGGQGWLWGGCSDNVGFGEAISKQFVDALET-----GQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 293
Cdd:cd19344    98 SASEGWKWGGCSDNVDYGIWFARKFVDAPEKserkrSRDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVSGSCEVKTCWK 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 294 QLPEFREVGAHLKEKYHAALKVDL------LQGAGNSaagrgaiaDTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGR 367
Cdd:cd19344   178 TMPSFEEVGDFLKQKYENSIQIATkkskrrLRRRERR--------KRKVPISKDELVYIHKSPNYCVRDPKKGILGTSGR 249
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622963856 368 ECLRRGRAlgrweRRSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19344   250 ECNRTSTG-----PDSCDLLC--CGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTC 305
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
139-430 8.97e-92

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 280.28  E-value: 8.97e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNC--PERALQLSSHGGLrsANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 216
Cdd:cd19337    24 SVGRGAKLAIEECQYQFRYRRWNCstPDSSSVFGPVTNI--GTREAAFTYAISAAGVVHAIARACREGNLSTCGCSRERR 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 217 GQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQD--------ARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTT 288
Cdd:cd19337   102 PKDLPRDWLWGGCGDNIEYGYKFAKEFIDARERETNyprhsrelARVLMNLHNNEAGRRAVYEKARVACKCHGVSGSCSL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 289 QTCWLQLPEFREVGAHLKEKYHAALKVDLLQgagnsaagRGAIA----DTFRSISTRELVHLEDSPDYCLENKTLGLLGT 364
Cdd:cd19337   182 KTCWRQLAPFREVGDRLKDKYDGAVKVKLNR--------RGTLLrrrnSRFNKPTKDDLVYLDDSPDYCERNPKTGSLGT 253
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1622963856 365 EGRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19337   254 KGRECNKTSSGTD-----GCELLC--CGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHIC 312
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
138-430 8.50e-90

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 275.39  E-value: 8.50e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 138 SSVAAGAQSGIEECKYQFAWDRWNCPeraLQLSSHGG------LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 211
Cdd:cd19333    17 HAIARGARMAIKECKWQFRNRRWNCP---TTDSRGGPnvfgkiLNRGCRETAFIYAITSAAVTHSVARACSEGSIESCSC 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 212 DDSRnGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTC 291
Cdd:cd19333    94 DYRR-RGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKCHGMSGSCTVKTC 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 292 WLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIAD------TFRSISTRELVHLEDSPDYCLENKTLGLLGTE 365
Cdd:cd19333   173 WMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLlepenpNHKPPTSKDLVYFEESPNFCEKNPKLGTLGTR 252
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 366 GRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19333   253 GRECNATSIGLD-----GCDLMC--CGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
139-430 2.05e-88

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 271.96  E-value: 2.05e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDdSRNG 217
Cdd:cd19335    27 SVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSVFGPvLDKASRESAFVHAIASAGVAHAVTRACAEGDSTSCGCD-SRHK 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 218 QLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPE 297
Cdd:cd19335   106 GPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELKTCWWAQPD 185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 298 FREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIA--DTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 375
Cdd:cd19335   186 FRKIGDYLKDKYDSASEMVVERHRESRGWVETLRPkyKLFKPPTERDLIYYEESPNFCEPNPETGSFGTRGRECNVTSHG 265
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1622963856 376 LgrwerRSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19335   266 I-----DGCDLLC--CGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTC 313
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
143-422 5.17e-87

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 268.36  E-value: 5.17e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 143 GAQSGIEECKYQFAWDRWNCP--ERALQLS-SHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQL 219
Cdd:cd19342    31 GIQLAVHECQRQFRDHRWNCSslETKNKNPhTSPILSRGYRETAFAYAISAAGVAHQVARACSLGKLLSCGCDRSRRGKR 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 220 GGQGW-LWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 298
Cdd:cd19342   111 SSGNDwKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKCKCHGMSGSCELKTCWKAAPDF 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 299 REVGAHLKEKYHAALKVDLLQGaGNSAAGRGAIADTF-RSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALG 377
Cdd:cd19342   191 REVGDILKEKYDHATLVDQSNL-NNGARRRRLTRRKRrRRPPKTDLVYYERSPNFCEADPSLDSPGTRGRVCNKTSTGPD 269
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1622963856 378 rwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCR 422
Cdd:cd19342   270 -----SCDSLC--CGRGYNTVRQTRTERCNCRFHWCCYVVCEKCT 307
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
138-430 4.29e-83

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 257.96  E-value: 4.29e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 138 SSVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHggLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDdSR 215
Cdd:cd19343    17 PSVVEAARLTVDTCQEQFADRRWNCSsiELAPNFTPD--LTRGTREQAFVYALSSAALTHTIARACASGALPGCGCG-RL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 216 NGQLGGQGWLWGGCSDNVGFGEAISKQFVDA-----LETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQT 290
Cdd:cd19343    94 PREPPDGDFKWGGCGDNVRYGLRFAKRFTDApekkkKKKKRQARALMNLHNNRVGRKAVRDSLETQCKCHGVSGSCSVKT 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 291 CWLQLPEFREVGAHLKEKYHAALKVDLLQgAGNSAAGRGAIADtFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECL 370
Cdd:cd19343   174 CWKALPDLSEVASRLKRKYARAVEVVSRK-VGSRRKLVPKSLK-VRPYTKDDLIYLTKSPDYCLPDEKLGSLGTRGRECN 251
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 371 RRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19343   252 KTSVGSD-----SCDSMC--CGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVC 304
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
139-430 1.94e-79

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 248.68  E-value: 1.94e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG--LRSAnRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 216
Cdd:cd19346    29 SIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRvmLRSS-REAAFVYAISSAGVVYAITRACSQGELKSCSCDPHKR 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 217 GQLGGQGWLW--GGCSDNVGFGEAISKQFVDALETG-QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 293
Cdd:cd19346   108 GRSHDERGEFdwGGCSDNINYGIKFAKAFVDAKEKKeKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCWL 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 294 QLPEFREVGAHLKEKYHAALKVDLLQ-GAGNSAAGRGaiadtFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRR 372
Cdd:cd19346   188 AMSDFRKTGDYLRKRYNGAVQVTMNQdGTGFTVANKN-----FRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKS 262
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622963856 373 GRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19346   263 SRGTD-----GCEVMC--CGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTC 313
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
139-430 6.35e-79

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 247.54  E-value: 6.35e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 139 SVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHGGLRSAnRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 216
Cdd:cd19345    29 AIGSGVKEWIAECQHQFRNHRWNCNtlDRDHSLFGRLLLRSS-RESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKK 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 217 GQLGGQGWLWG--GCSDNVGFGEAISKQFVDALE-TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 293
Cdd:cd19345   108 GSSKDSKGSFDwgGCSDNIDYGIRFARAFVDAKErKGKDARALMNLHNNRAGRKAVKRFMTLECKCHGVSGSCTVRTCWL 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 294 QLPEFREVGAHLKEKYHAALKVDLLQ-GAGNSAAGRgaiadTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRR 372
Cdd:cd19345   188 AMADFRKTGDYLRKKYNGAIQVVMNQdGTGFTVANK-----HFKKPTKNDLVYFENSPDYCVRDRDAGSLGTAGRVCNRT 262
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1622963856 373 GRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19345   263 SRGMD-----GCEVMC--CGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTC 313
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
148-430 5.73e-78

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 244.50  E-value: 5.73e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 148 IEECKYQFAWDRWNCperALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWG 227
Cdd:cd19341    27 VLECQEQFRYERWNC---SLGKYRINLLKKGYKETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLEENRQTWLWG 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 228 GCSDNVGFGEAISKQFVDALETG-QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLK 306
Cdd:cd19341   104 GCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILK 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 307 EKYHAALKVDLLQ----GAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGllGTEGRECLRrgralgrweRR 382
Cdd:cd19341   184 RKYEKAVKVVSENnaatGGSQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSP--GTKGRRCLK---------GD 252
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1622963856 383 SCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19341   253 NCDTLC--CGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTC 298
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
140-430 3.07e-73

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 233.02  E-value: 3.07e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 140 VAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQL 219
Cdd:cd19349    31 IGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQY 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 220 GGQGWLW-GGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 298
Cdd:cd19349   111 NQEEGWKwGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKF 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 299 REVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIAD--TFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRal 376
Cdd:cd19349   191 RELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKplSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQ-- 268
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1622963856 377 grwERRSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19349   269 ---QNNGCDLMC--CGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTC 317
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
140-430 6.68e-72

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 229.18  E-value: 6.68e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 140 VAAGAQSGIEECKYQFAWDRWNCPE--------RALQLSShgglrsanRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 211
Cdd:cd19347    25 IGEGAKTGIKECQYQFRHRRWNCSTvdntsvfgRVMQIGS--------RETAFTYAISAAGVVNAVSRACREGELSTCGC 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 212 DDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALE--------TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVS 283
Cdd:cd19347    97 SRAARPKDLPRDWLWGGCGDNLEYGYRFAKEFVDARErekiyqkgSYESARTLMNLHNNEAGRRTVYNLADVACKCHGVS 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 284 GSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLlqgagNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLG 363
Cdd:cd19347   177 GSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKL-----NSRGKLVQVNSRFNPPTTLDLVYIDPSPDYCVRNESTGSLG 251
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622963856 364 TEGRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19347   252 TQGRLCNKTSEGMD-----GCELMC--CGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVC 311
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
140-430 1.33e-70

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 226.02  E-value: 1.33e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 140 VAAGAQSGIEECKYQFAWDRWNCPE--------RALQLSShgglrsanRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 211
Cdd:cd19348    25 IGEGAKTGIKECQYQFRQRRWNCSTvdntsvfgRVMQIGS--------RETAFTYAVSAAGVVNAISRACREGELSTCGC 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 212 DDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALE--------TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVS 283
Cdd:cd19348    97 SRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREreknypkgSEEHARTLMNLQNNEAGRRAVYNLADVACKCHGVS 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 284 GSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLlqgagNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLG 363
Cdd:cd19348   177 GSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRI-----NRKGKLELVNSRFNPPTAEDLVYIDPSPDYCLRNETTGSLG 251
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1622963856 364 TEGRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19348   252 TQGRLCNKTSEGMD-----GCELMC--CGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVC 311
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
140-430 2.11e-69

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 222.96  E-value: 2.11e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 140 VAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCD-DSRNGQ 218
Cdd:cd19350    31 IGEGAQMGINECQYQFRYGRWNCSALGERTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDrEKQGYY 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 219 LGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 298
Cdd:cd19350   111 NQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCHGVSGSCTTKTCWTTLPKF 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 299 REVGAHLKEKYHAALKVDLLQgagnsaAGRGAIADTFRSISTR--------ELVHLEDSPDYCLENKTLGLLGTEGRECL 370
Cdd:cd19350   191 REIGYVLKEKYNAAVQVEVVR------ASRLRQPTFLKIKKRRsyqkpmetDLVYIERSPNYCEEDAATGSVGTQGRLCN 264
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 371 RRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19350   265 RTSPHTD-----GCDLMC--CGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTC 317
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
147-430 5.06e-62

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 203.21  E-value: 5.06e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 147 GIEECKYQFAWDRWNCperalQLSSHGGL-RSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWL 225
Cdd:cd19354    26 GLLECQFQFRSERWNC-----SLEGRGSLlKRGFKETAFLYAVSSAALTHSLAKACSSGRMERCTCDDSPGLENREAWQW 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 226 WGgCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHL 305
Cdd:cd19354   101 GV-CGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFHETGRLL 179
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 306 KEKYHAALKVdllQGAGNSAAGRGAIADTFRSISTR--------ELVHLEDSPDYCLENKTlgLLGTEGRECLRRGralg 377
Cdd:cd19354   180 KLKYENAVKV---HSVTNDATGETELWSPERHGHTLkghsprstDLVYLEDSPSFCRPSKY--SPGTAGRTCSRET---- 250
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1622963856 378 rwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19354   251 -----NCDSLC--CGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTC 296
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
137-422 3.28e-61

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 201.36  E-value: 3.28e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 137 SSSVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHGGLRSAN-RETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDd 213
Cdd:cd19355    25 TASAIQGIQIAIHECQHQFRDHRWNCSslETRNKIPYESVVFSRGfRESAFAYAIAAAGVVHAVSNACAMGKLKACGCD- 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 214 srngqlggqgWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 293
Cdd:cd19355   104 ----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSCQLKTCWQ 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 294 QLPEFREVGAHLKEKYHAAlkvdLLQGAGNSAAGR--GAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLR 371
Cdd:cd19355   174 VTPEFRTVGSLLKDRFYVA----TLIKPHNRNTGQlePGHAPHRRRASINDLVYFEKSPDFCEREPRLDSAGTQGRICNK 249
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1622963856 372 RGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCR 422
Cdd:cd19355   250 TSPGMD-----NCESLC--CGRGHNILRQTRSERCNCKFHWCCYVVCEECR 293
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
150-430 1.01e-58

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 194.87  E-value: 1.01e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 150 ECKYQFAWDRWNCPERALQLSSHggLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWGgC 229
Cdd:cd19353    29 ECQYQFRFERWNCTLEGRYRASL--LKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCTCDEAPDLENREAWQWGG-C 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 230 SDNVGFGEAISKQFVdALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLKEKY 309
Cdd:cd19353   106 GDNLKYSNKFVKEFL-GRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKY 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 310 HAALKVDllqGAGNSAAGRGAIADTFRSIS--------TRELVHLEDSPDYCLENKTLGllGTEGRECLRrgralgrweR 381
Cdd:cd19353   185 ETSLKVG---STTNEATGEGDISPPKKSGAghsdqiprTTDLVYIDDSPSFCLMSRFSP--GTSGRRCYK---------D 250
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1622963856 382 RSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 430
Cdd:cd19353   251 KNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTC 297
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
137-422 2.03e-56

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 188.56  E-value: 2.03e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 137 SSSVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDd 213
Cdd:cd19356    25 TASALQGIQIAIHECQHQLRDQRWNCSslEGGGKLPHDSAiLKRGFRESAFSFSLLAAGVMHSVATACSLGKLRGCGCE- 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 214 srngqlggqgWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 293
Cdd:cd19356   104 ----------WEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWH 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622963856 294 QLPEFREVGAHLKEKYHAALKVDlLQGAGNSAAGRGAiadTFRSIStRELVHLEDSPDYCLENKTLGLLGTEGRECLRRG 373
Cdd:cd19356   174 VTPEFRLVGALLREKFQRAIFIN-SHNKNSGVFLPRL---RPRRLA-RELVYFEKSPDFCERDPAVDSPGTQGRICNKTS 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1622963856 374 RALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCR 422
Cdd:cd19356   249 PGMD-----GCGSLC--CGRGHNILKQTRSERCHCRFHWCCYVLCEECR 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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