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Conserved domains on  [gi|966958200|ref|XP_015000686|]
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phospholipid phosphatase 5 isoform X5 [Macaca mulatta]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130247)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to mammalian phospholipid phosphatases that catalyzes the conversion of phosphatidic acid to diacylglycerol

EC:  3.1.3.-
Gene Ontology:  GO:0006644|GO:0008195|GO:0046839
PubMed:  12447906

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 81-212 1.67e-73

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


:

Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 222.09  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  81 NGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHC 154
Cdd:cd03390   58 NGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHI 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966958200 155 FTPqgRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQY 212
Cdd:cd03390  138 FDP--RGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 81-212 1.67e-73

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 222.09  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  81 NGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHC 154
Cdd:cd03390   58 NGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHI 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966958200 155 FTPqgRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQY 212
Cdd:cd03390  138 FDP--RGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 82-224 2.65e-55

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 179.74  E-value: 2.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  82 GVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFt 156
Cdd:PLN02250 111 GVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF- 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966958200 157 pQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQYYPPLTDAECHKP 224
Cdd:PLN02250 190 -DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPPPYDIDGWGP 256
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 82-213 1.58e-25

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 97.11  E-value: 1.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200   82 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAGklhcftpqgRG 161
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLRR---------LR 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966958200  162 KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQYY 213
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
84-209 1.09e-24

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 94.34  E-value: 1.09e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200    84 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 163
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 966958200   164 WRFCAFLspLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCY 209
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 88-212 9.39e-12

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.98  E-value: 9.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  88 IKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFC 167
Cdd:COG0671   92 LKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAAAAFALALVLALLL---------------PRRW 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966958200 168 AFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQY 212
Cdd:COG0671  143 LAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
 
Name Accession Description Interval E-value
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 81-212 1.67e-73

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 222.09  E-value: 1.67e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  81 NGVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLM------CTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHC 154
Cdd:cd03390   58 NGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLvgidicCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSLYLAGKLHI 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 966958200 155 FTPqgRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQY 212
Cdd:cd03390  138 FDP--RGSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
PLN02250 PLN02250
lipid phosphate phosphatase
 82-224 2.65e-55

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 179.74  E-value: 2.65e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  82 GVFTNTIKLIVGRPRPDFFYRCFPDGLA-----HSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFt 156
Cdd:PLN02250 111 GVITDAIKDAVGRPRPDFFWRCFPDGKGvfhpvTTDVLCTGAKSVIKEGHKSFPSGHTSWSFAGLGFLSLYLSGKIRVF- 189

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966958200 157 pQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQYYPPLTDAECHKP 224
Cdd:PLN02250 190 -DRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVASFCYLQFFPPPYDIDGWGP 256
PLN02731 PLN02731
Putative lipid phosphate phosphatase
 82-225 3.01e-46

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 156.73  E-value: 3.01e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  82 GVFTNTIKLIVGRPRPDFFYRCFPDGLAH----SDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFtp 157
Cdd:PLN02731 130 AVLTDAIKNAVGRPRPDFFWRCFPDGKALydslGDVICHGDKSVIREGHKSFPSGHTSWSFSGLGFLSLYLSGKIQAF-- 207

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966958200 158 QGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQYYPPLTDAECHKPF 225
Cdd:PLN02731 208 DGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLAISTICYLQFFPPPYHTEGWGPY 275
PLN02715 PLN02715
lipid phosphate phosphatase
 82-241 1.37e-41

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 144.43  E-value: 1.37e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  82 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSD----LMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHCFTP 157
Cdd:PLN02715 136 GVITDSIKVATGRPRPNFYWRCFPDGKELYDalggVICHGKAAEVKEGHKSFPSGHTSWSFAGLTFLSLYLSGKIKAFNG 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200 158 QGRGKswRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQYYPPLTDAECHKPF-----QDKLALP 232
Cdd:PLN02715 216 EGHVA--KLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAFCYRQFYPNPYHEEGWGPYayfkaAQERGVP 293


                 ....*....
gi 966958200 233 TAQKKPGDS 241
Cdd:PLN02715 294 VASSQNGDA 302
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 83-207 5.09e-31

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 111.95  E-value: 5.09e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  83 VFTNTIKLIVGRPRPDFFYRCFPDG----------LAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKL 152
Cdd:cd03384   18 LLTDLGKYVTGRLRPHFLDVCKPNYtdltcsldhqYIADCTCCTGDPDLIREARLSFPSGHASLSMYAAVFLALYLQARL 97

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966958200 153 hcftpqgrgkSWRFCAFLSPLL------FAAVIALSRTCDYKHHWQDVLVGSMIGITFAYV 207
Cdd:cd03384   98 ----------KLRGSRLLRPLLqflllaLALYVGLSRISDYKHHWSDVLAGALLGSVIALF 148
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 81-209 1.57e-27

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 102.15  E-value: 1.57e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  81 NGVFTNTIKLIVGRPRPDFFYRCFPDGlahsdlmctgDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLhcftpqgr 160
Cdd:cd01610   15 GLLLTGVLKYLFGRPRPYFLLRCGPDG----------DPLLLTEGGYSFPSGHAAFAFALALFLALLLPRRL-------- 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966958200 161 gksWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCY 209
Cdd:cd01610   77 ---LRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 82-213 1.58e-25

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 97.11  E-value: 1.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200   82 GVFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMctgdkdvvnEGRKSFPSGHSSFAFAGLAFASFYLAGklhcftpqgRG 161
Cdd:pfam01569  10 GLLSSVLKDYFGRPRPFFLLLEGGLVPAPSTLP---------GLGYSFPSGHSATAFALALLLALLLRR---------LR 71

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 966958200  162 KSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQYY 213
Cdd:pfam01569  72 KIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
84-209 1.09e-24

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 94.34  E-value: 1.09e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200    84 FTNTIKLIVGRPRPDFFYRCfpdglahsDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpQGRGKS 163
Cdd:smart00014  10 FNGVIKNYFGRPRPFFLSIG--------DACCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLYL---------PARAGR 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 966958200   164 WRFCAFLspLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCY 209
Cdd:smart00014  73 KLLIFLL--LLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
 82-212 3.87e-12

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 63.11  E-value: 3.87e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  82 GVFTNTIKLIVGRPRPDFFyrcFPDGLAHSDLMCTGDkdvvneGRKSFPSGHSSFAFAgLAFASFYLAGKlhcftpqgrg 161
Cdd:cd03389   82 GILVNLLKFIIGRARPKLL---FDDGLYGFDPFHADY------AFTSFPSGHSATAGA-AAAALALLFPR---------- 141

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 966958200 162 ksWRFCAflspLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQY 212
Cdd:cd03389  142 --YRWAF----ILLALLIAFSRVIVGAHYPSDVIAGSLLGAVTALALYQRF 186
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 85-206 5.64e-12

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 60.42  E-value: 5.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  85 TNTIKLIVGRPRPDffyrcfpdglahsdlmctGDkdvvNEGRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrGKSW 164
Cdd:cd03394   19 TEGLKFAVGRARPD------------------GS----NNGYRSFPSGHTASAFAAATFLQYRY------------GWRW 64

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 966958200 165 rfcAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAY 206
Cdd:cd03394   65 ---YGIPAYALASLVGASRVVANRHWLSDVLAGAAIGILVGY 103
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 88-212 9.39e-12

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 61.98  E-value: 9.39e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  88 IKLIVGRPRPdFFYRCFPDGLAHSDlmctgdkdvvnegRKSFPSGHSSFAFAGLAFASFYLagklhcftpqgrgksWRFC 167
Cdd:COG0671   92 LKYLFGRPRP-FVVPDLELLLGTAG-------------GYSFPSGHAAAAFALALVLALLL---------------PRRW 142

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 966958200 168 AFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYRQY 212
Cdd:COG0671  143 LAALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLLALL 187
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 82-212 1.69e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 61.09  E-value: 1.69e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  82 GVFTNTIKLIVGRPRPDFFYRCFPDGLahsdlmctgdkdvvnegrkSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrG 161
Cdd:cd03392   75 GALNTLLKLLVQRPRPPLHLLVPEGGY-------------------SFPSGHAMGATVLYGFLAYLLARRLP-------R 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 966958200 162 KSWRFCAFLSPLLFAAVIALSRTcdYKH-HW-QDVLVGSMIGITFAYVCYRQY 212
Cdd:cd03392  129 RRVRILLLILAAILILLVGLSRL--YLGvHYpSDVLAGWLLGLAWLALLILLY 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 81-210 1.37e-08

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 53.04  E-value: 1.37e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  81 NGVFTNTIKLIVGRPRPdffyrCFPDGLAHsdlmctgDKDVVNEGRK-SFPSGHSSFAFAGLAFASFYlagklhcftpqg 159
Cdd:cd03395   69 DQLASGFLKPLVARLRP-----CNALDGVR-------LVVLGDQGGSySFASSHAANSFALALFIWLF------------ 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 966958200 160 rgksWRFCAFLSPLLF-AAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYR 210
Cdd:cd03395  125 ----FRRGLFSPVLLLwALLVGYSRVYVGVHYPGDVIAGALIGIISGLLFYL 172
PAP2_containing_2_like cd03391
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. ...
 88-202 3.95e-07

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a membrane-associated phosphatidic acid phosphatase.


Pssm-ID: 239485 [Multi-domain]  Cd Length: 159  Bit Score: 48.47  E-value: 3.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  88 IKLIVGRPRPdffyrcfpdglAHsdlMCTGDKDVVNEGRKSFPSGHSSFAFAGLAFASFYLAGKLHcftpqgrgkswrfc 167
Cdd:cd03391   66 LKALVRRRRP-----------AY---NSPDMLDYVAVDKYSFPSGHASRAAFVARFLLNHLVLAVP-------------- 117

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 966958200 168 aFLSPL-LFAAVIALSRTCDYKHHWQDVLVGSMIGI 202
Cdd:cd03391  118 -LRVLLvLWATVVGISRVLLGRHHVLDVLAGAFLGY 152
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 81-209 1.36e-06

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 46.88  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  81 NGVFTNTIKLIVGRPRPDFfyrcfpdglaHSDLMCTGdkdvvnegrKSFPSGHSSFAFaglaFASFYLAGKLHCFTPQGR 160
Cdd:cd03382   54 NEALNYVLKRIIKEPRPCS----------GAYFVRSG---------YGMPSSHSQFMG----FFAVYLLLFIYLRLGRLN 110

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 966958200 161 GKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCY 209
Cdd:cd03382  111 SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILLGILWF 159
PAP2_like_6 cd03396
PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 83-210 1.55e-03

PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239490  Cd Length: 197  Bit Score: 38.43  E-value: 1.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966958200  83 VFTNTIKLIVGRPRPdFFYRCFPDGLAHSDLMCTGDKDvvNEGRKSFPSGHSSFAFAGLAFASFYLAgklhcftpqgRGK 162
Cdd:cd03396   81 LVVAILKSHWGRPRP-WDLTEFGGDAPYTPLFSGPSNG--CGKGCSFPSGHASAGFALLALYFLFRR----------RRP 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 966958200 163 SWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGITFAYVCYR 210
Cdd:cd03396  148 RLARLVLAAGLALGALMGLARMARGAHFLSDVLWSLLLVWLIALLLYR 195
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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