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Conserved domains on  [gi|966943006|ref|XP_014993804|]
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COMM domain-containing protein 8 isoform X1 [Macaca mulatta]

Protein Classification

COMM domain-containing protein 8( domain architecture ID 10140836)

COMM domain-containing protein 8 (COMMD8) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes and may also down-regulate activation of NF-kappa-B

Gene Symbol:  COMMD8
Gene Ontology:  GO:0005515
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-180 1.33e-94

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 271.98  E-value: 1.33e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006   7 TLLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAVVGKNLSDEEIFQQLNQLNSFH 86
Cdd:cd04756    1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006  87 QETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ--LALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQ 164
Cdd:cd04756   81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQlkLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                        170
                 ....*....|....*.
gi 966943006 165 NLIHSLEAANKVVLQL 180
Cdd:cd04756  161 NLISSLEAANKVVLQL 176
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-180 1.33e-94

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 271.98  E-value: 1.33e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006   7 TLLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAVVGKNLSDEEIFQQLNQLNSFH 86
Cdd:cd04756    1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006  87 QETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ--LALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQ 164
Cdd:cd04756   81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQlkLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                        170
                 ....*....|....*.
gi 966943006 165 NLIHSLEAANKVVLQL 180
Cdd:cd04756  161 NLISSLEAANKVVLQL 176
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-173 4.44e-12

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 58.33  E-value: 4.44e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966943006  113 SSAQLQDFDWQL--ALSSDKIAALRMPLLSLHLDVKEN-GEVKPYSIEMSREELQNLIHSLEAA 173
Cdd:pfam07258   1 SLPQLVDLDWRLdvQLSSSSLSKVNEPVVLLELKLSDGdGSSEEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd8 cd04756
COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of ...
 7-180 1.33e-94

COMM_Domain containing protein 8. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240104 [Multi-domain]  Cd Length: 176  Bit Score: 271.98  E-value: 1.33e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006   7 TLLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAVVGKNLSDEEIFQQLNQLNSFH 86
Cdd:cd04756    1 TPPELINLLPVAQIVKLLHRVVDGVCGRAYPRYQDYSAIWSLEEWTEVLESLATLFKQAVGKNSNDEEAKAQLSDLSSSH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006  87 QETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQ--LALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQ 164
Cdd:cd04756   81 QEALLKCVKSRKEEIRQALVNKTNSISSAQLQDFDWQlkLALSSDKLSSLQEPLLNLDLDVKENGILKPVSIEMNKEELQ 160

                        170
                 ....*....|....*.
gi 966943006 165 NLIHSLEAANKVVLQL 180
Cdd:cd04756  161 NLISSLEAANKVVLQL 176
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 93-177 1.51e-12

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 60.40  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006  93 CVKSRKDEIKQALSREivAISSAQLQDFDWQL--ALSSDKIAALRMP--LLSLHLDVKENGEVKPYSIEMSREELQNLIH 168
Cdd:cd04748    1 LLTENKAEIEELLSKQ--SLSLPQLVDFDWRLdvQISSSSLAKVKQPtiLVQLKLQVGDNNSSEKICFEMTKEELQNFLN 78


                 ....*....
gi 966943006 169 SLEAANKVV 177
Cdd:cd04748   79 KLKKIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 113-173 4.44e-12

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 58.33  E-value: 4.44e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966943006  113 SSAQLQDFDWQL--ALSSDKIAALRMPLLSLHLDVKEN-GEVKPYSIEMSREELQNLIHSLEAA 173
Cdd:pfam07258   1 SLPQLVDLDWRLdvQLSSSSLSKVNEPVVLLELKLSDGdGSSEEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 65-173 1.02e-03

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 38.18  E-value: 1.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966943006  65 VVGKNLSDEeiFQQLNqLNSFHQETIMKCVKSRKDEIKQALSREIVAISsaQLQDFDWQL--ALSSDKIAALRMPLLSLH 142
Cdd:cd04752   60 VDGESLSSE--LQQLG-LPKEHATSLCRSYEEKQSKLQESLRANSLRLS--RLESVDWRVdyILSSSELQEVNEPLVQLR 134

                         90       100       110
                 ....*....|....*....|....*....|...
gi 966943006 143 LDVK--ENGEVKPYSIEMSREELQNLIHSLEAA 173
Cdd:cd04752  135 LKVRnaDTGEITPHPFSVSADKFRVLLAELKQA 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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