NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|966942595|ref|XP_014993613|]
View 

protein sel-1 homolog 3 isoform X2 [Macaca mulatta]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
651-842 5.45e-37

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 5.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  651 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 730
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  731 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 807
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 966942595  808 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 842
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
651-842 5.45e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 5.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  651 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 730
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  731 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 807
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 966942595  808 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 842
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 703-733 1.16e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 1.16e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 966942595   703 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 733
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 768-806 1.03e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.54  E-value: 1.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 966942595    768 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 806
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
651-842 5.45e-37

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 139.68  E-value: 5.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  651 WLKHEATRGNAAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAA 730
Cdd:COG0790    53 AAAAAAAAGGAEAQYNLGLMYAEGR-GVPKDYEKALEWFEKAA-EQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAA 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  731 SKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHM 807
Cdd:COG0790   131 EQGDADAQYNLGLLYLNgegVPKDPAKAAEWYRKAAEQGDADAQYNLGVLYENGR--GVP-KDPAKALEWYRKAAEQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 966942595  808 EGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEK 842
Cdd:COG0790   208 DAQYNLGRLYLNG--EGVEKDLEKALRWLRKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
649-803 2.08e-31

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 123.50  E-value: 2.08e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  649 FMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDPALIYDYAIVLFKGQGVKKNRRLALELMKK 728
Cdd:COG0790    87 LEWFEKAAEQGDAEAQYNLGLMYEEG-LGVPQDYAKALEWYEKAA-EQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRK 164

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966942595  729 AASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQ 803
Cdd:COG0790   165 AAEQGDADAQYNLGVLYENgrgVPKDPAKALEWYRKAAEQGDADAQYNLGRLYLNGE--GVE-KDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
650-874 2.91e-28

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 114.64  E-value: 2.91e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  650 MWLKHEATRGNAAAQQRLAQMLFWGQQGVAKNPEAAIEWYAKGALETEDPALiYDYAIVLFKGQGVKKNRRLALELMKKA 729
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQ-YNLGLMYAEGRGVPKDYEKALEWFEKA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  730 ASKGLHQAVNGLGWYYHK---FKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 806
Cdd:COG0790    94 AEQGDAEAQYNLGLMYEEglgVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGE--GVP-KDPAKAAEWYRKAAEQGD 170

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 966942595  807 MEGTLWCSLYYITGnlETFPRDPEKAVVWAKHVAEKN-----GYLGHVIRKGLnaYLEGSWHEALLYYVLAAE 874
Cdd:COG0790   171 ADAQYNLGVLYENG--RGVPKDPAKALEWYRKAAEQGdadaqYNLGRLYLNGE--GVEKDLEKALRWLRKAAE 239
TPR COG0790
TPR repeat [General function prediction only];
673-899 1.45e-20

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 92.30  E-value: 1.45e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  673 WGQQGVAKNPEAAIEWYAKGALETEDPALIYDYAIVLFKGQGVKKNRRLALELMKKAASKGLHQAVNGLGWYYHK---FK 749
Cdd:COG0790     1 LALAAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEgrgVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  750 KNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGHMEGTLWCSLYYITGnlETFPRDP 829
Cdd:COG0790    81 KDYEKALEWFEKAAEQGDAEAQYNLGLMYEEGL--GVP-QDYAKALEWYEKAAEQGDADAQYNLGLLYLNG--EGVPKDP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  830 EKAVVWAKHVAEkNGY------LGHVIRKGLnaYLEGSWHEALLYYVLAAETGIEVSQTNLAHI------CEERPDLARR 897
Cdd:COG0790   156 AKAAEWYRKAAE-QGDadaqynLGVLYENGR--GVPKDPAKALEWYRKAAEQGDADAQYNLGRLylngegVEKDLEKALR 232


                  ..
gi 966942595  898 YL 899
Cdd:COG0790   233 WL 234
TPR COG0790
TPR repeat [General function prediction only];
720-973 8.45e-11

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 63.41  E-value: 8.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  720 RLALELMKKAASKGLHQAVNGLGWYYHKFKKNYAKAAKYWLKAEEMGNPDASYNLGVLHLDGIfpGVPgRNQTLAGEYFH 799
Cdd:COG0790    15 AAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGR--GVP-KDYEKALEWFE 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  800 KAAQGGHMEGTLWCSLYYITGnlETFPRDPEKAVVWakhvaekngylghvirkglnaylegswheallyYVLAAETGIEV 879
Cdd:COG0790    92 KAAEQGDAEAQYNLGLMYEEG--LGVPQDYAKALEW---------------------------------YEKAAEQGDAD 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  880 SQTNLahiceerpdlarrylgvncvwryynfsvfqidapsfaylkmGDLYYYGHQNQsQDLELSVQMYAQAALDGDSQGF 959
Cdd:COG0790   137 AQYNL-----------------------------------------GLLYLNGEGVP-KDPAKAAEWYRKAAEQGDADAQ 174

                         250
                  ....*....|....
gi 966942595  960 FNLALLIEEGTIIP 973
Cdd:COG0790   175 YNLGVLYENGRGVP 188
TPR COG0790
TPR repeat [General function prediction only];
540-730 7.88e-09

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 57.63  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  540 GYHKASYYLAVFYETGLNVPRDQLQGmlyslvggqgserlssmnlgykhyqgidnypldwelsyayysniatktpldqht 619
Cdd:COG0790   133 GDADAQYNLGLLYLNGEGVPKDPAKA------------------------------------------------------ 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  620 lqgdqayvetirlkddeilkvqtkedgdvFMWLKHEATRGNAAAQQRLAQMLFWGqQGVAKNPEAAIEWYAKGAlETEDP 699
Cdd:COG0790   159 -----------------------------AEWYRKAAEQGDADAQYNLGVLYENG-RGVPKDPAKALEWYRKAA-EQGDA 207

                         170       180       190
                  ....*....|....*....|....*....|.
gi 966942595  700 ALIYDYAIVLFKGQGVKKNRRLALELMKKAA 730
Cdd:COG0790   208 DAQYNLGRLYLNGEGVEKDLEKALRWLRKAA 238
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 659-770 1.04e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966942595  659 GNAAAQQRLAQMLFWgqqgvAKNPEAAIEWYAKG-ALETEDPALIYDYAIVLFKGQGVKKnrrlALELMKKAASK--GLH 735
Cdd:COG4235    15 NDAEGWLLLGRAYLR-----LGRYDEALAAYEKAlRLDPDNADALLDLAEALLAAGDTEE----AEELLERALALdpDNP 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 966942595  736 QAVNGLGWYYHKfKKNYAKAAKYWLKAEEMGNPDA 770
Cdd:COG4235    86 EALYLLGLAAFQ-QGDYAEAIAAWQKLLALLPADA 119
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 703-733 1.16e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 40.20  E-value: 1.16e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 966942595   703 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 733
Cdd:pfam08238    5 YRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 661-693 7.34e-04

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 37.89  E-value: 7.34e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 966942595   661 AAAQQRLAQMLFWGQqGVAKNPEAAIEWYAKGA 693
Cdd:pfam08238    1 AEAQYRLGYLYLYGL-GVPKDPEKALEWYEKAA 32
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 768-806 1.03e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 37.54  E-value: 1.03e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 966942595    768 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGGH 806
Cdd:smart00671    1 AEAQYNLGQMYEYGL--GVP-KDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 768-805 2.19e-03

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 36.73  E-value: 2.19e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 966942595   768 PDASYNLGVLHLDGIfpGVPgRNQTLAGEYFHKAAQGG 805
Cdd:pfam08238    1 AEAQYRLGYLYLYGL--GVP-KDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 703-733 3.01e-03

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 36.38  E-value: 3.01e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 966942595    703 YDYAIVLFKGQGVKKNRRLALELMKKAASKG 733
Cdd:smart00671    5 YNLGQMYEYGLGVPKDLEKALEYYKKAAELG 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH