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Conserved domains on  [gi|1622935034|ref|XP_014991288|]
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zinc finger and SCAN domain-containing protein 31 [Macaca mulatta]

Protein Classification

zinc finger and SCAN domain-containing protein( domain architecture ID 12210801)

zinc finger and SCAN domain-containing protein (ZSCAN) contains Cys2His2 (C2H2)-type zinc fingers and may act as a transcription factor

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677|GO:0003700|GO:0005515
PubMed:  11361095|22803940|30718982|10940247|12665246|11179890|10567577|12801630
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 2.94e-61

leucine rich region;


:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 193.29  E-value: 2.94e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034   35 QEASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1622935034  115 EDLEQELSEPGNQALDHEHGHsEVLSEEVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-393 4.07e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 232 HSTAERRHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC----- 300
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssk 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 301 --GKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHT 374
Cdd:COG5048   363 fsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442

                         170
                  ....*....|....*....
gi 1622935034 375 GEKPYQCSQCSKLFSKQTL 393
Cdd:COG5048   443 NHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 2.94e-61

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 193.29  E-value: 2.94e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034   35 QEASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1622935034  115 EDLEQELSEPGNQALDHEHGHsEVLSEEVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 35-123 1.57e-51

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 167.28  E-value: 1.57e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034  35 QEASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 1622935034 115 EDLEQELSE 123
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 36-119 2.14e-41

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 140.86  E-value: 2.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034  36 EASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVE 115
Cdd:cd07936     2 ETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAE 81


                  ....
gi 1622935034 116 DLEQ 119
Cdd:cd07936    82 DLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-393 4.07e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 232 HSTAERRHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC----- 300
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssk 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 301 --GKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHT 374
Cdd:COG5048   363 fsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442

                         170
                  ....*....|....*....
gi 1622935034 375 GEKPYQCSQCSKLFSKQTL 393
Cdd:COG5048   443 NHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 3.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 3.97e-05
                          10        20
                  ....*....|....*....|...
gi 1622935034 310 LTRHRRIHTGEKPYECKVCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
mukB PRK04863
chromosome partition protein MukB;
53-209 1.24e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034   53 PREALSRLRELCRQW------------LKPEIHTKEQILEL-----LVLEQFLTILPEELQAwvREHHPESGEEAVAVVE 115
Cdd:PRK04863   491 RSEAWDVARELLRRLreqrhlaeqlqqLRMRLSELEQRLRQqqraeRLLAEFCKRLGKNLDD--EDELEQLQEELEARLE 568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034  116 DLEQELSEPGNQALDHEHgHSEVLSEEVEHLKvKQEPTDIQLQPMVTQLkyesfrlhqfREQDGESIPENQELVskQEIL 195
Cdd:PRK04863   569 SLSESVSEARERRMALRQ-QLEQLQARIQRLA-ARAPAWLAAQDALARL----------REQSGEEFEDSQDVT--EYMQ 634

                          170
                   ....*....|....
gi 1622935034  196 KEMEHLRDSRLQRD 209
Cdd:PRK04863   635 QLLERERELTVERD 648
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
35-146 2.94e-61

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 193.29  E-value: 2.94e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034   35 QEASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:smart00431   1 PEIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLL 80

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1622935034  115 EDLEQELSEPGNQALDHEHGHsEVLSEEVEHL 146
Cdd:smart00431  81 EDLERELDEPGQQVSAHVHGQ-EVLLEKMVPL 111
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
 35-123 1.57e-51

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 167.28  E-value: 1.57e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034  35 QEASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVV 114
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80


                  ....*....
gi 1622935034 115 EDLEQELSE 123
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
 36-119 2.14e-41

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 140.86  E-value: 2.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034  36 EASRQLFRQFCYQETPGPREALSRLRELCRQWLKPEIHTKEQILELLVLEQFLTILPEELQAWVREHHPESGEEAVAVVE 115
Cdd:cd07936     2 ETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLAE 81


                  ....
gi 1622935034 116 DLEQ 119
Cdd:cd07936    82 DLLA 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
232-393 4.07e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 232 HSTAERRHRCNECGKSFTKSSVLIEHQR--IHTGE--KPYECEE--CGKAFSRRSSLNEHRRSHTGEKPYQCKEC----- 300
Cdd:COG5048   283 EKGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnsssk 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 301 --GKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHTGEKRYQCR--ECGKAFIQNAGLFQHLRVHT 374
Cdd:COG5048   363 fsPLLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT 442

                         170
                  ....*....|....*....
gi 1622935034 375 GEKPYQCSQCSKLFSKQTL 393
Cdd:COG5048   443 NHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
220-402 1.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 220 CKQDSRAEKQQGHSTAERRHRCNECGKSFTKSSVLIEHQRIHTGE-------KPYECEECGKAFSRRSSLNEHRRS--HT 290
Cdd:COG5048   236 SPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHS 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 291 GE--KPYQCKE--CGKAFSASNGLTRHRRIHTGEKPYECK--VCGKAF--LLSSCLVQHQRIHTGEKRYQCRE-----CG 357
Cdd:COG5048   316 GEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFspLLNNEPPQSLQQYKDLKNDKKSEtlsnsCI 395

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1622935034 358 KAFIQNAGLFQHLRVHTGEKPYQC--SQCSKLFSKQTLLKKHQKIHT 402
Cdd:COG5048   396 RNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
265-325 2.07e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.07e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622935034 265 KPYECEECGKAFSRRSSLNEHRRSHTGEKPYQCKECGKAFSASNG--LTRHRRIHTGEKPYEC 325
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-294 2.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 207 QRDVSLDSKYRETCKQDSRAEkqqghSTAERRHRCNECGKSFTKSSVLIEHQRIHTGEKPYEC--EECGKAFSRRSSLNE 284
Cdd:COG5048     7 QSSSSNNSVLSSTPKSTLKSL-----SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSR 81

                          90
                  ....*....|
gi 1622935034 285 HRRSHTGEKP 294
Cdd:COG5048    82 HLRTHHNNPS 91
zf-H2C2_2 pfam13465
Zinc-finger double domain;
310-332 3.97e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 3.97e-05
                          10        20
                  ....*....|....*....|...
gi 1622935034 310 LTRHRRIHTGEKPYECKVCGKAF 332
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
254-278 4.09e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.09e-05
                          10        20
                  ....*....|....*....|....*
gi 1622935034 254 LIEHQRIHTGEKPYECEECGKAFSR 278
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 4.38e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.38e-05
                          10        20
                  ....*....|....*....|....*
gi 1622935034 281 SLNEHRRSHTGEKPYQCKECGKAFS 305
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
338-362 1.36e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.36e-04
                          10        20
                  ....*....|....*....|....*
gi 1622935034 338 LVQHQRIHTGEKRYQCRECGKAFIQ 362
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 263-314 1.89e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 1.89e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1622935034 263 GEKPYECE--ECGKAFSRRSSLNEHRR---------------SHTG----EKPYQCKECGKAFSASNGLTRHR 314
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspeKMNIfsakDKPYRCEVCDKRYKNLNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-346 2.40e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.15  E-value: 2.40e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1622935034 293 KPYQCKECGKAFSASNGLTRHRRIHTGEKPYECKV--CGKAFLLSSCLVQHQRIHT 346
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 267-289 4.78e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 4.78e-04
                          10        20
                  ....*....|....*....|...
gi 1622935034 267 YECEECGKAFSRRSSLNEHRRSH 289
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
366-390 8.14e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.14e-04
                          10        20
                  ....*....|....*....|....*
gi 1622935034 366 LFQHLRVHTGEKPYQCSQCSKLFSK 390
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
mukB PRK04863
chromosome partition protein MukB;
53-209 1.24e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 41.10  E-value: 1.24e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034   53 PREALSRLRELCRQW------------LKPEIHTKEQILEL-----LVLEQFLTILPEELQAwvREHHPESGEEAVAVVE 115
Cdd:PRK04863   491 RSEAWDVARELLRRLreqrhlaeqlqqLRMRLSELEQRLRQqqraeRLLAEFCKRLGKNLDD--EDELEQLQEELEARLE 568

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034  116 DLEQELSEPGNQALDHEHgHSEVLSEEVEHLKvKQEPTDIQLQPMVTQLkyesfrlhqfREQDGESIPENQELVskQEIL 195
Cdd:PRK04863   569 SLSESVSEARERRMALRQ-QLEQLQARIQRLA-ARAPAWLAAQDALARL----------REQSGEEFEDSQDVT--EYMQ 634

                          170
                   ....*....|....
gi 1622935034  196 KEMEHLRDSRLQRD 209
Cdd:PRK04863   635 QLLERERELTVERD 648
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 291-374 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 1.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622935034 291 GEKPYQCK--ECGKAFSASNGLTRHRRI-HTGEKPYEckvcgkafllSSCLVQHQRIHTGEKRYQCRECGKAFIQNAGLF 367
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1622935034 368 QHlRVHT 374
Cdd:COG5189   416 YH-RKHS 421
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 295-317 4.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|...
gi 1622935034 295 YQCKECGKAFSASNGLTRHRRIH 317
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-261 4.18e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.18e-03
                          10        20
                  ....*....|....*....|...
gi 1622935034 239 HRCNECGKSFTKSSVLIEHQRIH 261
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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