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Conserved domains on  [gi|1622833544|ref|XP_014990071|]
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fibronectin type III domain-containing protein 5 isoform X1 [Macaca mulatta]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10812976)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-124 6.48e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 6.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  34 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1622833544 112 GQSPASEPVLFKT 124
Cdd:cd00063    81 GESPPSESVTVTT 93
DUF4808 super family cl24589
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 151-184 3.80e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


The actual alignment was detected with superfamily member pfam16066:

Pssm-ID: 374343  Cd Length: 121  Bit Score: 39.00  E-value: 3.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622833544 151 RTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEP 184
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALFFNRWGKIRMLEP 36
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-124 6.48e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 6.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  34 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1622833544 112 GQSPASEPVLFKT 124
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 34-114 6.57e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 6.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544   34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAIS--QQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1622833544  112 GQS 114
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
35-117 2.62e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  35 SAPVNVTVRHLKANSAVVSWDVLED--EVVIGFAIsqQKKDVRMLRFIQEVNT--TTRSCALWDLEEDTEYIVHVQAISI 110
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEV--EYRPKNSGEPWNEITVpgTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 1622833544 111 QGQSPAS 117
Cdd:pfam00041  79 GGEGPPS 85
DUF4808 pfam16066
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 151-184 3.80e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


Pssm-ID: 374343  Cd Length: 121  Bit Score: 39.00  E-value: 3.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622833544 151 RTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEP 184
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALFFNRWGKIRMLEP 36
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
34-120 1.60e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTT----TrscalwDLEEDTEYIVHVQAIS 109
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306

                          90
                  ....*....|..
gi 1622833544 110 IQG-QSPASEPV 120
Cdd:COG3401   307 AAGnESAPSNVV 318
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 34-124 6.48e-16

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 70.22  E-value: 6.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  34 PSAPVNVTVRHLKANSAVVSWDVLEDE--VVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDDggPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 1622833544 112 GQSPASEPVLFKT 124
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 34-114 6.57e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 59.55  E-value: 6.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544   34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAIS--QQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQ 111
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGA 80


                   ...
gi 1622833544  112 GQS 114
Cdd:smart00060  81 GEG 83
fn3 pfam00041
Fibronectin type III domain;
35-117 2.62e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.11  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  35 SAPVNVTVRHLKANSAVVSWDVLED--EVVIGFAIsqQKKDVRMLRFIQEVNT--TTRSCALWDLEEDTEYIVHVQAISI 110
Cdd:pfam00041   1 SAPSNLTVTDVTSTSLTVSWTPPPDgnGPITGYEV--EYRPKNSGEPWNEITVpgTTTSVTLTGLKPGTEYEVRVQAVNG 78


                  ....*..
gi 1622833544 111 QGQSPAS 117
Cdd:pfam00041  79 GGEGPPS 85
DUF4808 pfam16066
Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. ...
 151-184 3.80e-04

Domain of unknown function (DUF4808); This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is typically between 106 and 135 amino acids in length.


Pssm-ID: 374343  Cd Length: 121  Bit Score: 39.00  E-value: 3.80e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1622833544 151 RTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEP 184
Cdd:pfam16066   3 RGEEILIVVLVLIVWVAAIALFFNRWGKIRMLEP 36
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
34-120 1.60e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.22  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1622833544  34 PSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTT----TrscalwDLEEDTEYIVHVQAIS 109
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDPVTESDATGYRVYRSNSGDGPFTKVATVTTTsytdT------GLTNGTTYYYRVTAVD 306

                          90
                  ....*....|..
gi 1622833544 110 IQG-QSPASEPV 120
Cdd:COG3401   307 AAGnESAPSNVV 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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