|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
766-991 |
5.16e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
:
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.46 E-value: 5.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 766 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 845
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 846 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 925
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966928326 926 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 991
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1443-1575 |
9.13e-58 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
:
Pssm-ID: 211397 Cd Length: 134 Bit Score: 195.58 E-value: 9.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1443 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1521
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 966928326 1522 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1575
Cdd:cd11559 81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1247-1359 |
4.52e-37 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
:
Pssm-ID: 397128 Cd Length: 113 Bit Score: 135.48 E-value: 4.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1247 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1326
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 966928326 1327 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1359
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| PRK07003 super family |
cl35530 |
DNA polymerase III subunit gamma/tau; |
283-569 |
1.03e-05 |
|
DNA polymerase III subunit gamma/tau;
The actual alignment was detected with superfamily member PRK07003:
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 50.23 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 283 SEPNLAVLSIPGDTMATIQMSVEE------STPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAST 356
Cdd:PRK07003 336 GELGLAPDEYAGFTMTLLRMLAFEpavtggGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 357 PLASHTVEIHEPNGMVPSEDLEPEVESSPElalPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVS--------EP 428
Cdd:PRK07003 416 AAAAATRAEAPPAAPAPPATADRGDDAADG---DAPVPAKANARASADSRCDERDAQPPADSGSASAPASdappdaafEP 492
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 429 EEQAKEVTASVAPATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELL----------------PSE 492
Cdd:PRK07003 493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvssdrgaRAA 572
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928326 493 STPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVP 569
Cdd:PRK07003 573 AAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSADEGFGGP 649
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
766-991 |
5.16e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.46 E-value: 5.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 766 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 845
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 846 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 925
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966928326 926 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 991
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1443-1575 |
9.13e-58 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 195.58 E-value: 9.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1443 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1521
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 966928326 1522 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1575
Cdd:cd11559 81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
767-994 |
1.79e-53 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 186.03 E-value: 1.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 767 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 846
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 847 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 926
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966928326 927 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 994
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1247-1359 |
4.52e-37 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 135.48 E-value: 4.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1247 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1326
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 966928326 1327 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1359
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1247-1359 |
4.56e-36 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 132.75 E-value: 4.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1247 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1326
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 966928326 1327 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1359
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1514-1597 |
1.27e-26 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 104.68 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1514 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1593
Cdd:smart00515 2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79
|
....
gi 966928326 1594 LREA 1597
Cdd:smart00515 80 LQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1526-1602 |
1.38e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 95.67 E-value: 1.38e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928326 1526 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1602
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
283-569 |
1.03e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 50.23 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 283 SEPNLAVLSIPGDTMATIQMSVEE------STPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAST 356
Cdd:PRK07003 336 GELGLAPDEYAGFTMTLLRMLAFEpavtggGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 357 PLASHTVEIHEPNGMVPSEDLEPEVESSPElalPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVS--------EP 428
Cdd:PRK07003 416 AAAAATRAEAPPAAPAPPATADRGDDAADG---DAPVPAKANARASADSRCDERDAQPPADSGSASAPASdappdaafEP 492
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 429 EEQAKEVTASVAPATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELL----------------PSE 492
Cdd:PRK07003 493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvssdrgaRAA 572
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928326 493 STPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVP 569
Cdd:PRK07003 573 AAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSADEGFGGP 649
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
147-458 |
3.04e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 42.25 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 147 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 224
Cdd:pfam17823 116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 225 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMATIQMSV 304
Cdd:pfam17823 195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 305 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPLQASTPLASHTVeihepngMVPSEDlEPEVESS 384
Cdd:pfam17823 271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAAPMGAQAQGPI-------IQVSTD-QPVHNTA 320
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966928326 385 PElalppacpsESPVPIAPTAQPeellNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMapSATSP 458
Cdd:pfam17823 321 GE---------PTPSPSNTTLEP----NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV--EATSP 379
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MIF4G |
pfam02854 |
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). ... |
766-991 |
5.16e-64 |
|
MIF4G domain; MIF4G is named after Middle domain of eukaryotic initiation factor 4G (eIF4G). Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA.
Pssm-ID: 397130 Cd Length: 203 Bit Score: 216.46 E-value: 5.16e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 766 FRRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlkvpttekpTVTVNFR 845
Cdd:pfam02854 1 LKKVKGILNKLSPENFEKLIKELLKLIMSDPELLKYLIELIFEKAVEEPNFIPAYARLCSGLNL---------RNPTDFG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 846 KLLLNRCQKEFEKdkdddevfekkqkemdeaataeergrlKEELEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCV 925
Cdd:pfam02854 72 IHLLNRLQEEFEK---------------------------RFELEENEQGNRRRRLGLVRFLGELYKFGLLTEKILFECL 124
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 966928326 926 VKLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKII---KEKKTSSRIRFMLQDVLDLR 991
Cdd:pfam02854 125 KELLSSLtkedlkrDLFNLECLLTLLTTIGKLLENEKLPKLMDQFLDEIQKYVlskDDPKLSSRLRFMLQDLIELR 200
|
|
| W2_eIF4G1_like |
cd11559 |
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar ... |
1443-1575 |
9.13e-58 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins; eIF4G1 is a component of the multi-subunit eukaryotic translation initiation factor 4F, which facilitates recruitment of the mRNA to the ribosome, a rate-limiting step during translation initiation. This C-terminal domain, whose structure resembles that of a set of concatenated HEAT repeats, has been associated with binding to/recruiting the kinase Mnk1, which phosphorylates eIF4E.
Pssm-ID: 211397 Cd Length: 134 Bit Score: 195.58 E-value: 9.13e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1443 LPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFETPLRVDVAVLKARAKLLQKYLC- 1521
Cdd:cd11559 1 LPLLRVQAELLKLLQEDPNPDELYKWIKENVSPELYASPGFVRALMTAVLKYAIEEKSLPEKEKALLEKYAPLLQKYLDd 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 966928326 1522 DEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPA 1575
Cdd:cd11559 81 DEQLQLQALYALQALVHTLEFPKGLLLRFFDALYDEDVIEEEAFLKWKEDVDPA 134
|
|
| MIF4G |
smart00543 |
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The ... |
767-994 |
1.79e-53 |
|
Middle domain of eukaryotic initiation factor 4G (eIF4G); Also occurs in NMD2p and CBP80. The domain is rich in alpha-helices and may contain multiple alpha-helical repeats. In eIF4G, this domain binds eIF4A, eIF3, RNA and DNA. Ponting (TiBS) "Novel eIF4G domain homologues (in press)
Pssm-ID: 214713 Cd Length: 200 Bit Score: 186.03 E-value: 1.79e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 767 RRVRSILNKLTPQMFQQLMKQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMAlKVPttekptvtvNFRK 846
Cdd:smart00543 2 KKVKGLINKLSPSNFESIIKELLKLNNSDKNLRKYILELIFEKAVEEPNFIPAYARLCALLNA-KNP---------DFGS 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 847 LLLNRCQKEFEKDkdddevfekkqkemdeaataeergrlkeeLEEARDIARRRSLGNIKFIGELFKLKMLTEAIMHDCVV 926
Cdd:smart00543 72 LLLERLQEEFEKG-----------------------------LESEEESDKQRRLGLVRFLGELYNFQVLTSKIILELLK 122
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 966928326 927 KLLKNH-------DEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIIKEKKT---SSRIRFMLQDVLDLRGSN 994
Cdd:smart00543 123 ELLNDLtkldpprSDFSVECLLSLLPTCGKDLEREKSPKLLDEILERLQDYLLKKDKtelSSRLRFMLELLIELRKNK 200
|
|
| MA3 |
pfam02847 |
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain ... |
1247-1359 |
4.52e-37 |
|
MA3 domain; Domain in DAP-5, eIF4G, MA-3 and other proteins. Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains.
Pssm-ID: 397128 Cd Length: 113 Bit Score: 135.48 E-value: 4.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1247 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1326
Cdd:pfam02847 1 LKRKIFLILEEYLSSGDYDEAARCLLKLGLPSQHHEVVKVLIECALEESKTYREFYGLLLERLCEFNLISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 966928326 1327 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1359
Cdd:pfam02847 81 VLEDLEDLELDIPNAWRNLAEFVARLISDDGLP 113
|
|
| MA3 |
smart00544 |
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and ... |
1247-1359 |
4.56e-36 |
|
Domain in DAP-5, eIF4G, MA-3 and other proteins; Highly alpha-helical. May contain repeats and/or regions similar to MIF4G domains Ponting (TIBS) "Novel eIF4G domain homologues" in press
Pssm-ID: 214714 Cd Length: 113 Bit Score: 132.75 E-value: 4.56e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1247 LEKKSKAIIEEYLHLNDMKEAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLYE 1326
Cdd:smart00544 1 LKKKIFLIIEEYLSSGDTDEAVHCLLELKLPEQHHEVVKVLLTCALEEKRTYREMYSVLLSRLCQANVISTKQFEKGFWR 80
|
90 100 110
....*....|....*....|....*....|...
gi 966928326 1327 ILELAEDMEIDIPHVWLYLAELVTPILQEGGVP 1359
Cdd:smart00544 81 LLEDIEDLELDIPNAWRNLAEFVARLISDGILP 113
|
|
| eIF5C |
smart00515 |
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5; |
1514-1597 |
1.27e-26 |
|
Domain at the C-termini of GCD6, eIF-2B epsilon, eIF-4 gamma and eIF-5;
Pssm-ID: 214705 Cd Length: 83 Bit Score: 104.68 E-value: 1.27e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1514 KLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqqGKGVALKSVTAFFKW 1593
Cdd:smart00515 2 PLLKFLAKDEEEQLELLYAIEEFCVELEKLGKLLPKILKSLYDADILEEEAILKWYEKAVSAE--GKKKVRKNAKPFVTW 79
|
....
gi 966928326 1594 LREA 1597
Cdd:smart00515 80 LQEA 83
|
|
| W2 |
pfam02020 |
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of ... |
1526-1602 |
1.38e-23 |
|
eIF4-gamma/eIF5/eIF2-epsilon; This domain of unknown function is found at the C-terminus of several translation initiation factors.
Pssm-ID: 460415 Cd Length: 76 Bit Score: 95.67 E-value: 1.38e-23
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928326 1526 ELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAFYSWESSKDPAEqQGKGVALKSVTAFFKWLREAEEESD 1602
Cdd:pfam02020 1 QVDLLLALQEFCAKLEELLKLLLKILKALYDLDIVEEEAILKWWEDVSSAE-KGMKKVRKQAKPFVEWLEEAEEESD 76
|
|
| W2 |
cd11473 |
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of ... |
1444-1569 |
3.70e-23 |
|
C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; This domain is found at the C-terminus of several translation initiation factors, including the epsilon chain of eIF2b, where it has been found to catalyze the conversion of eIF2.GDP to its active eIF2.GTP form. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211395 Cd Length: 135 Bit Score: 96.78 E-value: 3.70e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1444 PSEELNRQLEKLLKEG-SSNQRVFDWIEANLSEQQIASNTLVRALMTAVCYSAIIFE----TPLRVDVAVLKARAKLLQK 1518
Cdd:cd11473 2 KNKKLRDSLLKELEEDkSSDVESVKAAKSKLDLDPISLEEVVKVLLTAVVNAVESADsislTQKEQLVLVLKKYGPVLRE 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 966928326 1519 YLCD-EQKELQALYALQALVVT--LEQPPNLLRMFFDALYDEDVVKEDAFYSWE 1569
Cdd:cd11473 82 LLKLiKKDQLYLLLKIEKLCLQlkLSELISLLEKILDLLYDADVLSEEAILSWF 135
|
|
| W2_eIF2B_epsilon |
cd11558 |
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a ... |
1472-1602 |
1.26e-15 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon; eIF2B is a heteropentameric complex which functions as a guanine nucleotide exchange factor in the recycling of eIF-2 during the initiation of translation in eukaryotes. The epsilon and gamma subunits are sequence similar and both are essential in yeast. Epsilon appears to be the catalytically active subunit, with gamma enhancing its activity. The C-terminal domain of the eIF2B epsilon subunit contains bipartite motifs rich in acidic and aromatic residues, which are responsible for the interaction with eIF2. The structure of the domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211396 Cd Length: 169 Bit Score: 76.14 E-value: 1.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1472 NLSEQQIASNTlVRALMTAVCYSAIIFETPLRVDVAVLKARAK-LLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMF 1550
Cdd:cd11558 39 NVTDHDVRRAV-VKALLELILEVSSTSTAELLEALKKLLSKWGpLLENYVKSQDDQVELLLALEEFCLESEEGGPLFAKL 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 966928326 1551 FDALYDEDVVKEDAFYSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESD 1602
Cdd:cd11558 118 LHALYDLDILEEEAILEWWEEPDAGADEEMKKVRELVKKFIEWLEEAEEESD 169
|
|
| W2_eIF5 |
cd11561 |
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase ... |
1444-1602 |
1.84e-09 |
|
C-terminal W2 domain of eukaryotic translation initiation factor 5; eIF5 functions as a GTPase acceleration protein (GAP), as well as a GDP dissociation inhibitor (GDI) during translational initiation in eukaryotes. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211399 Cd Length: 157 Bit Score: 58.01 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1444 PSEELNR--QLEKLLKEGSSNQRVFDwIEANLSEQQIASNTLVRALmtavcysAIIFETPLRVD-VAVLKARAKLLQKYL 1520
Cdd:cd11561 1 EEEEDERvdELGEFLKKNKDESGLSE-LKEILKEAERLDVVKDKAV-------LVLAEVLFDENiVKEIKKRKALLLKLV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1521 CDEQKELQALYALQALVVtlEQPPNLLRMF---FDALYDEDVVKEDAFYSW---ESSKDPAEQQGKGVaLKSVTAFFKWL 1594
Cdd:cd11561 73 TDEKAQKALLGGIERFCG--KHSPELLKKVpliLKALYDNDILEEEVILKWyekVSKKYVSKEKSKKV-RKAAEPFVEWL 149
|
....*...
gi 966928326 1595 REAEEESD 1602
Cdd:cd11561 150 EEAEEEEE 157
|
|
| W2_eIF5C_like |
cd11560 |
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; ... |
1440-1600 |
6.96e-08 |
|
C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins; eIF5C appears to be essential for the initiation of protein translation; its actual function, and specifically that of the C-terminal W2 domain, are not well understood. The Drosophila ortholog, kra (krasavietz) or exba (extra bases), may be involved in translational inhibition in neural development. The structure of this C-terminal domain resembles that of a set of concatenated HEAT repeats.
Pssm-ID: 211398 [Multi-domain] Cd Length: 194 Bit Score: 54.53 E-value: 6.96e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1440 QRALPSEELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIASN--------TLVRALMTAVCYSA---IIFETPLRVdvav 1508
Cdd:cd11560 29 YRKQASQEIKKELQQELKEMIAEEEPVKEIIAAVKEQMKKSSlpehevvgLLWTALMDAVEWSKkedQIAEQALRH---- 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 1509 LKARAKLLQKYLCDEQKELQALYALQalVVTLEQPpNLLRMFFD---ALYDEDVVKEDAFYSWesSKDPAEQQGKGVALK 1585
Cdd:cd11560 105 LKKYAPLLAAFCTTARAELALLNKIQ--EYCYENM-KFMKVFQKivkLLYKADVLSEDAILKW--YKKGHSPKGKQVFLK 179
|
170
....*....|....*
gi 966928326 1586 SVTAFFKWLREAEEE 1600
Cdd:cd11560 180 QMEPFVEWLQEAEEE 194
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
283-569 |
1.03e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 50.23 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 283 SEPNLAVLSIPGDTMATIQMSVEE------STPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAST 356
Cdd:PRK07003 336 GELGLAPDEYAGFTMTLLRMLAFEpavtggGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAALAPKAA 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 357 PLASHTVEIHEPNGMVPSEDLEPEVESSPElalPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVS--------EP 428
Cdd:PRK07003 416 AAAAATRAEAPPAAPAPPATADRGDDAADG---DAPVPAKANARASADSRCDERDAQPPADSGSASAPASdappdaafEP 492
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 429 EEQAKEVTASVAPATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELL----------------PSE 492
Cdd:PRK07003 493 APRAAAPSAATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALdvlrnagmrvssdrgaRAA 572
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 966928326 493 STPVPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPAVPEVENQPPAGSNPGPESEGSGVP 569
Cdd:PRK07003 573 AAAKPAAAPAAAPKPAAPRVAVQVPTPRARAATGDAPPNGAARAEQAAESRGAPPPWEDIPPDDYVPLSADEGFGGP 649
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
60-570 |
3.96e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 48.78 E-value: 3.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 60 PSRAQPPSSAASRvqsaaparpgpaahvyPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQYPVQPGAPGFYPG 139
Cdd:PHA03247 2564 PDRSVPPPRPAPR----------------PSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP 2627
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 140 A-SPTEFGTYAGAYYPAQGVQQFPTGVAPAP---------VLMNQPPQIAPKRERKTIRIRDPNQGG---------KDIT 200
Cdd:PHA03247 2628 PpSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprraRRLGRAAQASSPPQRPRRRAARPTVGSltsladpppPPPT 2707
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 201 EEIMSGARTASTPTP--PQTGGGLEPQANGETPQVAVIVRPDDRSQGAIIADRPGLPGPEHSPSESQPSSPSPTPSPSPV 278
Cdd:PHA03247 2708 PEPAPHALVSATPLPpgPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 279 LEPGSE--PNLAVLSIPGDTMATIQMSVEESTPISR-ETGEPYRLSPEPTPLAEPILEVEVTLS---KPVPESEFSSSPL 352
Cdd:PHA03247 2788 VASLSEsrESLPSPWDPADPPAAVLAPAAALPPAASpAGPLPPPTSAQPTAPPPPPGPPPPSLPlggSVAPGGDVRRRPP 2867
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 353 QASTPlASHTVEIHEPNGMVPSEDLEPEVESSPELALPPACPSESPVPIAPTAQPEELLNGAPSP-------PAVDLSPV 425
Cdd:PHA03247 2868 SRSPA-AKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPpppppprPQPPLAPT 2946
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 426 SEPEEQAKEVTASVAP---ATILSATPAMAPSATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEELLPSESTPVPANLSQ 502
Cdd:PHA03247 2947 TDPAGAGEPSGAVPQPwlgALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLKQ 3026
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966928326 503 NL------EAAAATQVAVSVPKRrrkikelNKKEAVgDLLDAFKEANPAVPEVENQPPAGSNPGPESEgSGVPP 570
Cdd:PHA03247 3027 TLwppddtEDSDADSLFDSDSER-------SDLEAL-DPLPPEPHDPFAHEPDPATPEAGARESPSSQ-FGPPP 3091
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
91-578 |
3.67e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 3.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 91 GSQVMMIPSQISYPASQGAYYIPGQGRStyvvPTQQYPVQPG--APGFYPGASPTEfgtyagAYYP-----AQGVQQFPT 163
Cdd:PHA03247 2476 GAPVYRRPAEARFPFAAGAAPDPGGGGP----PDPDAPPAPSrlAPAILPDEPVGE------PVHPrmltwIRGLEELAS 2545
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 164 GVA--PAPVLMNQPPQIAPKRERKTIRIRdPNQGGKDITeeimsgARTASTPTPPQtggglepQANGETPQvavivrpDD 241
Cdd:PHA03247 2546 DDAgdPPPPLPPAAPPAAPDRSVPPPRPA-PRPSEPAVT------SRARRPDAPPQ-------SARPRAPV-------DD 2604
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 242 RSqgaiiaDRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMATIQMSVEESTPISRETGEPYRLS 321
Cdd:PHA03247 2605 RG------DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASS 2678
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 322 P--EPTPLAEPILEVEVTLSK----PVPESEFSSSPLQASTPLASHTVEIHEPNGMVPSEDLEPEVESSPELALPPACPS 395
Cdd:PHA03247 2679 PpqRPRRRAARPTVGSLTSLAdpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 396 ESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATilSATPAMAPSATSPAQEEEMEEEEEEEEEGE 475
Cdd:PHA03247 2759 RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPAD--PPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 476 AGEAESEKGGEELLPSESTPVPANlsqNLEAAAATQVAVSVPKRRRKIKELN-KKEAVGDLLDAFKEAnPAVPEVENQPP 554
Cdd:PHA03247 2837 TAPPPPPGPPPPSLPLGGSVAPGG---DVRRRPPSRSPAAKPAAPARPPVRRlARPAVSRSTESFALP-PDQPERPPQPQ 2912
|
490 500
....*....|....*....|....
gi 966928326 555 AGSNPGPESEGSgVPPRPEEADET 578
Cdd:PHA03247 2913 APPPPQPQPQPP-PPPQPQPPPPP 2935
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
307-460 |
7.40e-04 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 44.26 E-value: 7.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 307 STPISR-ETGEPYRLSPEPTPLAEPILeVEVTLSKPVPESEfSSSPLQASTPLASHTVEIHEPN--GMVPSEDLEPEVES 383
Cdd:PRK10811 844 RYPVVRpQDVQVEEQREAEEVQVQPVV-AEVPVAAAVEPVV-SAPVVEAVAEVVEEPVVVAEPQpeEVVVVETTHPEVIA 921
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 384 SPELALPP-------ACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMAPSAT 456
Cdd:PRK10811 922 APVTEQPQvitesdvAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEVETVTAVEPEV 1001
|
....
gi 966928326 457 SPAQ 460
Cdd:PRK10811 1002 APAQ 1005
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
412-578 |
8.73e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.10 E-value: 8.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 412 NGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMAPS----ATSPAQEEEMEEEEEEEEEGEAGEAESEKGGEE 487
Cdd:PRK12323 369 GGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAaaaaARAVAAAPARRSPAPEALAAARQASARGPGGAP 448
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 488 LLPSESTPVPANLSQNLEAAAATQVAVSVPKRRRKIKElNKKEAVGDLLDAFKEANPAVPEVenqPPAGSNPGPESEGSG 567
Cdd:PRK12323 449 APAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPA-AAPAPADDDPPPWEELPPEFASP---APAQPDAAPAGWVAE 524
|
170
....*....|.
gi 966928326 568 VPPRPEEADET 578
Cdd:PRK12323 525 SIPDPATADPD 535
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
191-455 |
2.42e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.76 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 191 DPNQGGKDITEEIMSGARTAS------------TPTPPQTGgglePQANGETPQVAVIVRPDDRSQGAIIADRP------ 252
Cdd:PRK10263 308 DPLLNGAPITEPVAVAAAATTatqswaapvepvTQTPPVAS----VDVPPAQPTVAWQPVPGPQTGEPVIAPAPegypqq 383
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 253 ---GLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMATIQMSVEESTPISRETGEPyrlsPEPTPLAE 329
Cdd:PRK10263 384 sqyAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEE----QQSTFAPQ 459
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 330 PILEVEVTLSKPVPESEFSSSPLQASTPLASHTV-EIHEPNGMVPSEDLEPEVESS-----PELAL---PPACPSESPVP 400
Cdd:PRK10263 460 STYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpVVEETKPARPPLYYFEEVEEKrarerEQLAAwyqPIPEPVKEPEP 539
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 966928326 401 IAPTAQPEELLNGAPSPPAVDLSPVSEPEEQAkevtASVAPATILSATPAMAPSA 455
Cdd:PRK10263 540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKA----TLATGAAATVAAPVFSLAN 590
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
147-458 |
3.04e-03 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 42.25 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 147 TYAGAYYPAQGVQQFPTGVAPAPVLMNQPPQIAPKRERKTIRIRDPNQGGKDiTEEIMSGARTA--STPTPPQTGGGLEP 224
Cdd:pfam17823 116 AAAASSSPSSAAQSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASA-PHAASPAPRTAasSTTAASSTTAASSA 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 225 QANGETPQVAVIVRPDDRSQGAIIADRPGLpGPEHSPSESQPSSPSPTPSPSPVLEPGSepnLAVLSIPGDTMATIQMSV 304
Cdd:pfam17823 195 PTTAASSAPATLTPARGISTAATATGHPAA-GTALAAVGNSSPAAGTVTAAVGTVTPAA---LATLAAAAGTVASAAGTI 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 305 EESTPISRetgepyRLSPeptplaepilevevtlSKPVPESEFSSSPLQASTPLASHTVeihepngMVPSEDlEPEVESS 384
Cdd:pfam17823 271 NMGDPHAR------RLSP----------------AKHMPSDTMARNPAAPMGAQAQGPI-------IQVSTD-QPVHNTA 320
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 966928326 385 PElalppacpsESPVPIAPTAQPeellNGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPAMapSATSP 458
Cdd:pfam17823 321 GE---------PTPSPSNTTLEP----NTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV--EATSP 379
|
|
| TALPID3 |
pfam15324 |
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ... |
294-429 |
5.09e-03 |
|
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.
Pssm-ID: 434634 [Multi-domain] Cd Length: 1288 Bit Score: 41.80 E-value: 5.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 294 GDTMATIQMSVEESTPISRETGEPYRLSPEPTPLAEPilevevTLSKPVPESEfsssPLQASTPLASHTVEIHEpngMVP 373
Cdd:pfam15324 959 GDREAQREPPVAASVPGDLPTKETLLPTPVPTPQPTP------PCSPPSPLKE----PSPVKTPDSSPCVSEHD---FFP 1025
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 966928326 374 SEDLEPEVESSPELALPPA-CPSESPVPIAPTAqpeellnGAPSPP----AVDLSPVSEPE 429
Cdd:pfam15324 1026 VKEIPPEKGADTGPAVSLViTPTVTPIATPPPA-------ATPTPPlsenSIDKLKSPSPE 1079
|
|
| PHA03325 |
PHA03325 |
nuclear-egress-membrane-like protein; Provisional |
298-458 |
5.99e-03 |
|
nuclear-egress-membrane-like protein; Provisional
Pssm-ID: 223044 Cd Length: 418 Bit Score: 41.02 E-value: 5.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 298 ATIQMSVEESTPISRETG-EPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQASTplashtveihepnGMVPSED 376
Cdd:PHA03325 262 FMLNSSLPTSAPKRRSRRaGAMRAAAGETADLADDDGSEHSDPEPLPASLPPPPVRRPRV-------------KHPEAGK 328
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 966928326 377 LEPEVESSPElALPPACPSESP-VPIAPTAQPEEllnGAPSPPAVDLSPVSEPEEQAKEVTASVAPATILSATPaMAPSA 455
Cdd:PHA03325 329 EEPDGARNAE-AKEPAQPATSTsSKGSSSAQNKD---SGSTGPGSSLAAASSFLEDDDFGSPPLDLTTSLRHMP-SPSVT 403
|
...
gi 966928326 456 TSP 458
Cdd:PHA03325 404 SAP 406
|
|
| |
